Rtp3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver isoform ratio XM_039081612.1 0.02 0.02 5.6e-03 0.01 0.01 0.01 0 4.1e-02 1.6e-02 6.6e-02 7.5e-02
2 Liver alternative TSS XM_006243965.4 0.04 0.03 2.7e-04 0.02 0.02 0.01 0.01 6.2e-03 1.3e-03 7.8e-03 8.8e-03
3 Liver alternative TSS XM_039081612.1 0.03 0.03 3.2e-04 0.02 0.02 0.01 0.01 6.0e-03 1.4e-03 8.8e-03 1.1e-02
4 Liver alternative TSS XM_006243965.4 0.4 0.23 0.0e+00 0.18 0.2 0.19 0.18 1.0e-19 1.7e-21 7.0e-21 5.5e-20
5 Liver isoform ratio XM_006243965.4 0.28 0.17 0.0e+00 0.16 0.17 0.17 0.17 5.6e-18 8.5e-19 2.5e-18 3.5e-18
6 Liver alternative TSS NM_001108190.1 0.76 0.13 0.0e+00 0.17 0.19 0.19 0.19 7.4e-19 6.3e-21 3.6e-20 3.3e-20
7 Liver isoform ratio NM_001108190.1 0.45 0.26 0.0e+00 0.16 0.17 0.14 0.17 1.0e-17 1.2e-18 7.9e-16 3.3e-18
8 Adipose gene expression Rtp3 0.71 0.11 0.0e+00 0.22 0.35 0.35 0.34 1.4e-23 2.0e-40 2.6e-40 1.1e-38
9 Liver gene expression Rtp3 0.1 0.09 2.9e-03 0.01 0.01 0.01 0.01 1.8e-02 2.2e-02 7.1e-03 4.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.00.10.30.2-0.20.2-0.2-0.20.30.20.1-0.6
Area under the delay curve2.32.43.2-1.61.6-1.61.51.5-1.5-1.5-1.4-1.8
BMI with tail0.31.15.11.2-1.11.1-0.6-0.70.10.5-0.22.3
BMI without tail1.22.63.71.9-1.91.9-1.6-1.61.31.51.01.5
Body weight6.125.729.65.4-5.45.4-5.0-5.14.75.04.15.3
Weight adjusted by age0.40.41.50.6-0.60.6-0.5-0.50.40.50.51.2
Bone surface0.10.10.4-0.30.3-0.30.30.3-0.3-0.4-0.6-0.1
Bone volume0.00.00.2-0.10.1-0.10.20.2-0.1-0.2-0.4-0.1
Breakpoint value in progressive ratio session0.10.10.20.2-0.20.2-0.3-0.30.40.30.3-0.4
Number of licking bursts0.10.10.2-0.40.4-0.40.40.4-0.4-0.4-0.20.4
Context. condit. distance diff. score0.00.00.20.0-0.00.0-0.1-0.10.20.1-0.10.4
Locomotion velocity, session 10.10.10.3-0.30.3-0.30.30.3-0.4-0.3-0.4-0.6
Locomotion distance, session 10.40.61.01.0-0.90.9-0.8-0.80.80.80.20.0
Locomotion velocity, session 20.40.40.9-0.60.6-0.60.70.7-0.7-0.7-0.9-0.0
Locomotion distance, session 20.20.20.9-0.10.1-0.10.30.3-0.5-0.4-0.8-0.9
Locomotion velocity, session 30.00.00.10.3-0.20.2-0.1-0.10.00.0-0.4-0.3
Locomotion distance, session 31.21.42.4-1.01.1-1.11.21.2-1.2-1.2-1.5-1.0
Stereotopy head waving bouts, day 30.30.32.20.2-0.20.2-0.2-0.20.10.20.41.5
Stereotopy head waving duration, day 30.40.51.00.6-0.60.6-0.7-0.70.60.70.91.0
Locomotion velocity, session 70.40.40.70.6-0.60.6-0.6-0.60.60.60.5-0.8
Locomotion distance, session 70.70.82.3-0.80.8-0.80.80.8-0.8-0.8-0.8-1.5
Stereotopy head waving bouts, day 70.20.21.1-0.30.3-0.30.20.3-0.2-0.3-0.2-1.0
Stereotopy head waving duration, day 70.20.20.30.4-0.40.4-0.5-0.40.50.40.4-0.3
Locomotion velocity, session 80.10.10.20.5-0.40.4-0.3-0.30.40.3-0.30.4
Locomotion distance, session 80.10.10.30.5-0.40.4-0.3-0.30.30.2-0.4-0.5
Degree of sensitization distance1.51.52.31.2-1.21.2-1.3-1.31.31.31.50.3
Degree of sensitization stereotypy0.20.21.9-0.00.0-0.0-0.1-0.00.20.10.1-1.4
Conditioned locomotion2.73.23.6-1.91.9-1.91.81.8-1.7-1.8-1.5-1.8
Cocaine response after cond. corrected0.40.51.90.5-0.50.5-0.5-0.50.40.50.61.4
Cocaine response after cond. not corrected1.82.03.71.4-1.41.4-1.3-1.41.11.31.31.9
Cocaine response before conditioning0.80.91.31.1-1.11.1-1.0-1.00.91.00.60.5
Saline control response1.51.92.41.4-1.41.4-1.5-1.51.51.51.6-0.4
Bone: connectivity density0.30.42.4-0.60.5-0.50.40.5-0.3-0.4-0.3-1.5
Bone: cortical apparent density0.20.30.9-0.60.6-0.60.40.5-0.1-0.4-0.4-1.0
Bone: cortical area0.20.31.2-0.40.4-0.40.40.4-0.3-0.4-0.41.1
Bone: cortical porosity0.40.54.1-0.10.1-0.1-0.00.00.10.00.4-2.0
Bone: cortical porosity0.50.54.3-0.40.3-0.30.20.2-0.2-0.20.2-2.1
Bone: cortical thickness0.30.63.70.4-0.40.4-0.4-0.40.50.40.21.9
Bone: cortical thickness0.00.00.00.1-0.10.1-0.1-0.10.10.10.1-0.1
Bone: cortical tissue density0.30.41.1-0.60.6-0.60.40.5-0.1-0.4-0.4-1.0
Condit. Reinf. active minus inactive responses0.20.20.50.3-0.40.4-0.5-0.50.60.50.70.3
Condit. Reinf. active-inactive response ratio0.40.50.80.5-0.60.6-0.7-0.70.80.70.90.7
Condit. Reinf. active responses0.00.00.0-0.20.1-0.10.10.1-0.0-0.10.1-0.0
Condit. Reinf. inactive responses0.70.91.1-0.90.9-0.91.01.0-1.0-1.0-0.9-0.8
Incentive salience index mean0.00.00.1-0.20.2-0.20.20.2-0.2-0.2-0.2-0.1
Condit. Reinf. lever presses1.62.22.7-1.41.4-1.41.61.5-1.7-1.6-1.6-1.0
Condit. Reinf. active minus inactive responses2.12.63.21.7-1.61.6-1.6-1.61.71.61.21.8
Condit. Reinf. active-inactive response ratio1.51.62.51.3-1.31.3-1.2-1.21.11.20.91.6
Condit. Reinf. active responses1.92.63.61.6-1.61.6-1.6-1.61.81.61.31.9
Condit. Reinf. inactive responses0.00.00.2-0.10.1-0.1-0.00.00.30.10.00.4
Condit. Reinf. lever presses2.33.13.81.8-1.81.8-1.8-1.81.81.81.21.9
Condit. Reinf. lever reinforcers received2.13.03.81.7-1.71.7-1.7-1.71.81.71.41.9
Conditioned reinforcement - actives0.30.30.5-0.50.5-0.50.60.5-0.6-0.5-0.6-0.7
Conditioned reinforcement - inactives0.80.91.1-1.01.0-1.01.01.0-1.1-1.0-1.00.7
Conditioned locomotion0.50.62.2-0.60.6-0.60.70.7-0.8-0.7-0.7-1.5
Patch foraging indifference point 0 sec1.11.72.01.4-1.41.4-1.4-1.41.41.41.4-0.2
Patch foraging indifference point AUC0.20.20.90.2-0.20.2-0.3-0.30.50.30.1-1.0
Delay disc. indifference point, 0s delay0.00.00.1-0.10.1-0.10.20.2-0.4-0.2-0.2-0.2
Delay disc. indifference point, 16s delay1.21.21.5-1.11.1-1.11.11.1-1.1-1.1-1.0-1.2
Delay disc. indifference point, 2s delay0.30.40.5-0.60.6-0.60.60.6-0.6-0.6-0.6-0.7
Delay disc. indifference point, 24s delay0.90.91.2-1.01.0-1.00.91.0-0.8-0.9-0.9-1.1
Delay disc. indifference point, 4s delay2.12.22.5-1.61.6-1.61.51.5-1.4-1.5-1.5-1.3
Delay disc. indifference point, 8s delay2.12.22.7-1.51.5-1.51.51.5-1.5-1.5-1.3-1.7
Indifference point function ln k0.40.51.2-0.40.5-0.50.80.7-1.1-0.8-1.00.7
Indifference point function log k0.40.51.2-0.40.5-0.50.80.7-1.1-0.8-1.00.7
Patch foraging total patch changes 0 sec1.22.02.31.5-1.51.5-1.5-1.51.41.51.50.2
Patch foraging total patch changes 12 sec0.91.22.21.0-1.11.1-1.2-1.11.51.21.1-0.0
Patch foraging total patch changes 18 sec3.03.85.11.9-1.91.9-2.1-2.12.32.12.1-0.3
Patch foraging total patch changes 24 sec2.83.44.12.0-1.91.9-2.0-1.92.02.01.71.1
Patch foraging total patch changes 6 sec0.20.41.40.4-0.40.4-0.5-0.50.60.50.5-1.2
Patch foraging time to switch 0 sec0.10.20.2-0.50.5-0.50.40.4-0.4-0.4-0.20.2
Patch foraging water rate 0 sec0.10.20.30.5-0.50.5-0.5-0.50.50.50.30.4
Patch foraging water rate 12 sec0.30.41.00.7-0.70.7-0.6-0.60.40.50.41.0
Patch foraging water rate 18 sec0.30.42.70.2-0.10.10.20.1-0.7-0.2-0.51.7
Patch foraging water rate 24 sec0.70.91.01.0-1.01.0-1.0-1.00.91.01.00.8
Patch foraging water rate 6 sec0.20.20.40.6-0.60.6-0.5-0.50.50.50.10.3
Seeking ratio, delayed vs. immediate footshock2.22.63.2-1.61.6-1.61.71.6-1.8-1.7-1.4-1.4
Distance traveled before self-admin0.20.21.80.2-0.20.2-0.1-0.20.00.10.21.4
Distance traveled after self-admin0.20.20.3-0.50.5-0.50.40.5-0.3-0.4-0.50.2
Extensor digitorum longus weight0.10.60.8-0.80.8-0.80.80.8-0.9-0.8-0.80.3
Bone: elastic displacement0.20.21.50.2-0.20.2-0.3-0.30.30.30.21.2
Bone: elastic work0.70.93.70.8-0.80.8-0.7-0.70.70.70.31.9
Bone: endosteal estimation0.10.20.40.5-0.50.5-0.5-0.50.40.50.6-0.3
Bone: endosteal perimeter1.12.33.2-1.51.5-1.51.61.6-1.8-1.6-1.4-0.9
Epididymis fat weight0.30.70.80.8-0.90.9-0.8-0.80.70.80.80.9
Delta time in closed arm before/after self-admin0.20.20.4-0.30.3-0.30.40.3-0.5-0.4-0.3-0.7
Delta time in open arm before/after self-admin0.30.30.80.5-0.50.5-0.6-0.50.90.60.4-0.2
Diff in mean of infusions in LGA sessions0.10.11.0-0.10.1-0.10.10.1-0.1-0.1-0.11.0
Delay discount exponential model param2.62.73.01.7-1.71.7-1.7-1.71.61.71.51.7
Extinction: sum of active levers before priming0.10.10.30.2-0.20.2-0.2-0.2-0.00.20.3-0.5
Active lever presses in extinction session 60.30.30.40.6-0.70.7-0.6-0.60.40.60.7-0.2
Bone: final force0.91.43.11.2-1.11.1-1.1-1.11.11.10.91.8
Bone: final moment1.11.84.21.3-1.31.3-1.2-1.31.21.21.02.0
Food consumed during 24 hour testing period1.31.62.71.3-1.31.3-1.2-1.20.91.21.01.6
Glucose0.20.30.40.6-0.60.6-0.5-0.50.50.50.4-0.6
Heart weight2.53.56.51.8-1.81.8-1.8-1.81.81.81.52.5
Delay discount hyperbolic model param2.62.73.21.7-1.71.7-1.6-1.71.61.71.51.8
Intermittent access intake day 1-15 change0.50.51.0-0.70.7-0.70.70.6-0.6-0.6-0.61.0
Intermittent access intake escalation0.30.30.8-0.50.5-0.50.50.5-0.5-0.5-0.50.9
Intermittent access intake escalation 20.30.32.40.2-0.20.2-0.2-0.20.20.20.11.5
Intermitt. access day 1 inactive lever presses0.00.00.1-0.10.1-0.10.20.1-0.3-0.2-0.20.1
Intermitt. access day 15 inactive lever presses0.70.80.9-0.90.9-0.90.90.9-1.0-0.9-0.90.7
Intermitt. access escalation Index0.10.10.60.1-0.10.1-0.0-0.1-0.10.00.1-0.8
Intermittent access day 1 total infusions0.00.00.1-0.10.1-0.10.20.1-0.3-0.2-0.2-0.3
Intermittent access day 15 total infusions0.20.20.3-0.40.4-0.40.50.4-0.6-0.5-0.50.2
Intermittent access terminal intake (last 3 days)0.10.10.2-0.20.2-0.20.30.3-0.4-0.3-0.30.0
Intermittent access total infusions0.30.40.7-0.60.6-0.60.70.6-0.8-0.6-0.7-0.2
Intermittent access day 1 locomotion0.20.20.6-0.40.4-0.40.40.4-0.4-0.4-0.4-0.8
Intermittent access day 15 total locomotion0.60.61.4-0.70.7-0.70.80.7-0.9-0.8-0.7-1.2
Intermittent access total locomotion1.21.42.3-1.11.1-1.11.21.1-1.3-1.2-1.1-1.5
Intermittent access standard deviation0.60.63.90.5-0.40.4-0.5-0.50.70.50.32.0
Left kidney weight0.30.91.61.3-1.21.2-1.0-1.00.80.90.40.0
Right kidney weight0.10.20.40.6-0.60.6-0.4-0.40.20.3-0.0-0.3
Cocaine induced anxiety0.50.60.8-0.80.8-0.80.80.8-0.9-0.8-0.70.0
Post-drug Anxiety0.20.30.3-0.60.6-0.60.50.6-0.6-0.6-0.4-0.0
Baseline Anxiety0.10.10.1-0.40.4-0.40.30.4-0.3-0.4-0.3-0.4
Tail length6.620.124.04.6-4.64.6-4.7-4.74.94.74.32.7
Length with tail9.233.737.36.0-6.06.0-6.0-6.06.16.05.54.3
Length without tail6.414.015.03.9-3.93.9-3.8-3.83.73.83.43.5
Times rat made contact with spout0.40.50.60.7-0.70.7-0.7-0.70.60.70.80.7
Lifetime Intake0.30.30.5-0.50.5-0.50.60.5-0.7-0.6-0.6-0.4
Liver weight, left0.20.31.90.2-0.30.3-0.4-0.30.50.40.7-1.4
Liver weight, right1.01.62.01.4-1.41.4-1.3-1.31.31.31.10.4
Locomotor activity5.68.89.93.1-3.13.1-3.1-3.13.13.12.72.1
Locomotor testing distance5.18.59.93.1-3.13.1-3.0-3.02.93.02.72.0
Locomotor testing rearing0.30.50.70.7-0.70.7-0.7-0.80.70.80.90.3
Locomotion in novel chamber0.10.20.2-0.40.4-0.40.40.4-0.4-0.4-0.50.3
Locomotion in novel chamber post-restriction0.70.81.01.0-1.01.0-1.0-1.01.01.00.8-0.1
Fecal boli incidents, locomotor time 10.50.50.80.7-0.70.7-0.7-0.70.70.70.50.9
Change in fecal boli incidents, locomotor task0.00.00.10.2-0.20.2-0.2-0.20.10.20.2-0.2
Time >=10cm from walls, locomotor time 10.20.20.9-0.40.4-0.40.30.3-0.3-0.3-0.2-0.9
Bouts of movement, locomotor time 10.00.00.10.1-0.10.1-0.2-0.10.30.20.10.2
Total resting periods, locomotor time 10.00.00.10.1-0.10.1-0.2-0.10.20.20.10.2
Rest time, locomotor task time 10.50.50.8-0.70.7-0.70.80.7-0.9-0.8-0.6-0.7
Distance moved, locomotor task time 11.51.72.11.3-1.31.3-1.3-1.31.31.31.11.4
Vertical activity count, locomotor time 10.70.70.90.8-0.80.8-0.9-0.81.00.90.80.7
Time >=10cm from walls, locomotor time 21.51.51.71.3-1.31.3-1.3-1.31.31.31.20.9
Bouts of movement, locomotor time 20.10.10.70.2-0.20.2-0.1-0.1-0.00.1-0.00.8
Total resting periods, locomotor time 20.10.10.3-0.10.1-0.10.20.1-0.3-0.2-0.30.6
Rest time, locomotor task time 20.00.00.1-0.10.1-0.10.10.1-0.1-0.1-0.2-0.3
Distance moved, locomotor task time 20.81.01.41.0-1.01.0-1.0-0.91.00.90.91.2
Vertical activity count, locomotor time 20.00.00.00.2-0.20.2-0.2-0.20.20.20.20.1
Light reinforcement 10.50.91.11.1-1.11.1-1.0-1.00.90.90.80.6
Light reinforcement 20.30.40.7-0.40.4-0.40.60.6-0.8-0.7-0.8-0.9
Bone: marrow area0.10.30.40.5-0.50.5-0.5-0.50.40.50.6-0.2
Bone: maximum diameter0.40.70.8-0.90.9-0.90.90.9-0.9-0.9-0.90.4
Bone: maximum force0.71.31.61.1-1.11.1-1.1-1.11.11.11.01.3
Bone: maximum moment0.81.52.21.2-1.21.2-1.2-1.21.11.21.11.5
Mean time between licks in bursts1.01.41.6-1.21.2-1.21.31.2-1.3-1.2-1.30.1
Mean num. licks in bursts0.40.50.60.8-0.80.8-0.8-0.80.80.80.7-0.0
Cd content in liver3.03.34.81.7-1.71.7-1.9-1.92.01.92.21.3
Co content in liver0.10.10.70.2-0.20.2-0.2-0.20.10.20.20.8
Cu content in liver3.84.65.22.3-2.32.3-2.2-2.32.12.32.21.1
Fe content in liver2.53.04.71.5-1.51.5-1.8-1.82.11.92.21.1
K content in liver0.50.50.90.8-0.70.7-0.7-0.71.00.70.20.5
Mg content in liver0.10.10.6-0.00.1-0.10.10.20.0-0.2-0.80.2
Mn content in liver0.40.50.70.8-0.80.8-0.7-0.70.80.70.10.0
Na content in liver0.60.71.50.6-0.60.6-0.9-0.81.20.91.0-0.1
Rb content in liver2.02.55.41.2-1.31.3-1.6-1.61.81.72.30.9
Se content in liver0.10.10.40.1-0.00.0-0.1-0.10.40.1-0.20.6
Sr content in liver0.20.10.60.00.0-0.00.30.3-0.5-0.4-0.80.2
Zn content in liver3.74.15.12.3-2.22.2-2.1-2.11.92.11.81.1
Bone: minimum diameter0.30.61.1-0.70.8-0.80.90.8-1.0-0.9-0.8-0.1
Time in familiar zone, hab. session 10.70.71.1-1.01.0-1.00.80.8-0.7-0.8-0.5-0.1
Time in novel zone, hab. session 10.30.30.40.7-0.60.6-0.6-0.60.40.50.50.2
Total zone transitions, hab. session 10.30.40.70.9-0.80.8-0.6-0.60.40.50.1-0.1
Total locomotion distance, hab. session 10.10.10.30.5-0.50.5-0.4-0.40.30.40.10.1
Locomotion velocity, hab. session 10.10.20.30.6-0.50.5-0.4-0.40.40.40.1-0.1
Time in familiar zone, hab. session 20.30.30.4-0.70.7-0.70.60.6-0.4-0.5-0.60.6
Time in novel zone, hab. session 20.10.10.60.2-0.20.2-0.1-0.2-0.10.10.4-0.8
Total zone transitions, hab. session 20.00.10.30.2-0.20.20.10.0-0.3-0.1-0.60.0
Total locomotion distance, hab. session 20.10.10.30.5-0.50.5-0.4-0.40.40.4-0.00.1
Locomotion velocity, hab. session 20.10.10.10.4-0.30.3-0.3-0.30.30.2-0.2-0.1
Novel to familiar place preference ratio0.90.91.71.0-1.01.0-0.9-0.90.80.90.9-1.3
Novelty place preference1.01.02.11.0-1.01.0-0.9-0.90.80.90.9-1.4
Time in novel zone, NPP test1.21.21.51.1-1.11.1-1.1-1.11.01.11.1-1.2
Total zone transitions, NPP test1.21.73.01.7-1.61.6-1.3-1.41.01.20.50.5
Total locomotion distance, NPP test0.60.81.21.1-1.11.0-0.9-0.90.80.90.40.7
Locomotion velocity, NPP test0.60.81.31.1-1.11.1-0.9-1.00.90.90.40.5
Intraocular pressure1.42.03.61.3-1.31.3-1.5-1.51.51.51.90.0
Delta distance traveled before/after self-admin0.30.30.8-0.60.6-0.60.50.6-0.3-0.5-0.6-0.9
Delta ambulatory time before/after self-admin0.20.20.40.4-0.40.4-0.5-0.40.60.50.3-0.4
Parametrial fat weight0.81.51.91.4-1.41.4-1.3-1.31.21.31.10.2
Pavlov. Cond. lever latency5.57.08.62.7-2.72.7-2.8-2.82.82.82.91.4
Pavlov. Cond. magazine entry latency6.28.09.0-3.03.0-3.03.03.0-2.8-2.9-3.0-1.4
Pavlov. Cond. change in total contacts1.31.41.8-1.31.3-1.31.21.2-1.0-1.2-1.2-0.7
Pavlov. Cond. index score6.27.88.9-3.03.0-3.02.92.9-2.8-2.9-3.0-1.4
Pavlov. Cond. latency score6.27.99.1-2.92.9-3.02.92.9-2.8-2.9-3.0-1.5
Pavlov. Cond. lever contacts3.33.95.1-2.02.0-2.02.12.1-2.1-2.1-2.3-1.1
Pavlov. Cond. magazine entry number7.08.79.83.1-3.13.1-3.1-3.12.93.03.01.7
Pavlov. Cond. intertrial magazine entries0.40.50.60.7-0.70.8-0.8-0.80.80.80.80.3
Pavlov. Cond. lever-magazine prob. diff.5.46.77.7-2.82.8-2.82.72.7-2.6-2.7-2.8-0.9
Pavlov. Cond. response bias6.88.29.2-3.03.0-3.03.03.0-2.9-3.0-3.0-1.3
Pavlov. Cond. lever latency0.40.51.0-0.80.8-0.70.70.7-0.7-0.7-0.2-1.0
Pavlov. Cond. magazine entry latency0.30.30.9-0.30.4-0.40.50.5-0.5-0.5-1.00.5
Pavlov. Cond. change in total contacts2.53.45.51.9-1.91.8-1.8-1.81.91.81.22.3
Pavlov. Cond. index score0.20.21.50.3-0.30.3-0.1-0.20.20.2-0.41.2
Pavlov. Cond. latency score0.10.21.30.2-0.20.2-0.1-0.10.10.1-0.51.1
Pavlov. Cond. lever contacts0.81.11.41.2-1.11.1-1.0-1.11.01.00.61.0
Pavlov. Cond. magazine entry number0.40.51.20.6-0.60.6-0.7-0.70.70.71.1-0.5
Pavlov. Cond. intertrial magazine entries0.20.31.0-0.60.6-0.60.40.4-0.3-0.40.0-1.0
Pavlov. Cond. lever-magazine prob. diff.0.20.21.60.3-0.20.2-0.1-0.10.10.1-0.51.3
Pavlov. Cond. response bias0.10.10.80.3-0.20.2-0.1-0.10.10.1-0.40.9
Time in closed arm before self-admin1.82.12.11.5-1.41.4-1.4-1.51.41.51.41.4
Time in closed arm after self-admin0.00.00.10.2-0.20.2-0.1-0.2-0.10.10.20.3
Time in open arm before self-admin1.31.51.8-1.21.2-1.21.21.2-1.4-1.3-1.1-1.1
Time in open arm after self-admin0.50.63.7-0.50.5-0.50.40.4-0.1-0.4-0.4-1.9
Bone: periosteal estimation0.00.10.30.2-0.20.2-0.2-0.20.10.20.10.6
Bone: periosteal perimeter1.01.72.1-1.41.4-1.41.41.4-1.5-1.4-1.3-0.4
Bone: post-yield work0.00.00.00.2-0.20.2-0.1-0.1-0.00.10.10.0
Progressive ratio test 1 active lever presses0.10.10.80.0-0.00.00.10.0-0.1-0.0-0.0-0.9
Progressive ratio test 1 breakpoint0.10.10.9-0.10.1-0.10.20.1-0.3-0.2-0.1-0.9
Progressive ratio test 1 inactive lever presses0.30.40.4-0.60.7-0.70.70.6-0.6-0.6-0.60.2
Progressive ratio test 2 active lever presses0.80.91.1-1.01.0-1.01.01.0-1.0-1.0-1.0-0.7
Progressive ratio test 2 breakpoint0.70.81.0-0.90.9-0.90.90.9-1.0-0.9-0.9-0.5
Progressive ratio test 2 inactive lever presses1.92.12.7-1.51.5-1.51.61.5-1.6-1.6-1.50.1
Incentive Sensitization - Responses1.61.61.9-1.41.4-1.41.41.4-1.4-1.4-1.3-0.1
Incentive Sensitization - Breakpoint1.61.61.8-1.31.3-1.31.41.3-1.4-1.3-1.3-0.1
Sum of active levers in priming session hrs 5-60.40.40.60.6-0.60.6-0.7-0.70.80.70.7-0.1
Progressive ratio3.13.64.42.1-2.12.1-2.0-2.01.82.01.90.6
Food seeking constrained by brief footshock0.70.81.3-0.90.9-0.91.00.9-1.1-1.0-0.9-0.3
Seeking ratio, punishment vs. effort5.06.17.0-2.62.6-2.62.62.6-2.6-2.6-2.5-0.7
Retroperitoneal fat weight0.51.62.01.4-1.41.4-1.3-1.31.21.31.10.9
Reaction time number correct0.20.30.5-0.60.6-0.60.60.6-0.7-0.6-0.4-0.2
Reaction time mean minus median0.00.00.10.2-0.10.1-0.1-0.10.00.1-0.1-0.3
Reaction time mean minus median AUC0.10.20.20.5-0.50.5-0.4-0.40.30.40.3-0.3
Reaction time num false alarms0.30.41.7-0.60.5-0.50.50.5-0.4-0.5-0.2-1.3
Reaction time num false alarms AUC0.20.21.7-0.20.2-0.20.20.2-0.1-0.20.1-1.3
Reaction time trials correct on left0.20.30.5-0.60.6-0.60.60.6-0.7-0.6-0.4-0.2
Reaction time trials on left0.30.40.6-0.70.6-0.60.70.6-0.8-0.6-0.4-0.3
Reaction time mean0.00.00.10.1-0.10.1-0.1-0.20.20.20.2-0.1
Reaction time mean AUC0.00.00.20.0-0.00.0-0.1-0.10.00.10.2-0.4
Median of all reaction times0.00.00.10.1-0.10.1-0.2-0.20.30.20.4-0.1
Reaction time omissions0.20.30.9-0.60.6-0.50.40.4-0.3-0.30.2-0.9
Reaction time false alarm rate0.10.11.0-0.10.1-0.10.00.10.0-0.00.1-1.0
Reaction time premature initiation rate1.82.43.11.6-1.61.6-1.6-1.61.81.61.50.9
Reaction time premature initiations0.81.21.41.1-1.11.1-1.1-1.11.21.11.10.9
Std. dev. reaction times0.10.10.30.4-0.40.4-0.4-0.40.30.40.4-0.5
Reaction time trials completed0.30.40.6-0.70.6-0.60.70.6-0.8-0.6-0.4-0.3
Reaction time trials AUC0.30.50.7-0.70.7-0.70.70.7-0.8-0.7-0.5-0.4
Run reversals in cocaine runway, females1.71.72.1-1.41.4-1.41.41.4-1.4-1.4-1.2-0.4
Run reversals in cocaine runway, males0.40.40.80.5-0.50.5-0.7-0.60.90.70.50.7
Latency to leave start box in cocaine runway0.20.30.50.5-0.50.5-0.5-0.50.70.50.30.6
Latency to leave start box in cocaine runway, F1.41.53.31.1-1.11.1-1.2-1.11.41.20.91.8
Latency to leave start box in cocaine runway, M0.50.51.4-0.60.6-0.60.60.6-0.6-0.6-0.6-1.2
Std. dev. time between licks in bursts3.44.15.6-2.12.1-2.12.22.1-2.4-2.2-2.1-0.3
Total sessions with >9 infusions0.10.10.9-0.10.1-0.10.20.2-0.4-0.2-0.10.9
Short access day 1 total inactive lever presses3.03.34.6-1.81.8-1.92.01.9-2.1-1.9-1.9-0.6
Short access day 10 total inactive lever presses0.20.21.8-0.20.2-0.20.10.2-0.0-0.2-0.21.3
Short access day 1 total infusions0.80.81.1-0.90.9-0.91.00.9-1.1-1.0-0.9-0.2
Short access day 10 total infusions0.00.00.2-0.10.1-0.10.20.1-0.4-0.2-0.2-0.3
Short access total infusions0.50.50.8-0.60.7-0.70.70.7-0.9-0.7-0.7-0.7
Short access day 1 locomotion0.10.10.3-0.10.1-0.10.30.2-0.5-0.3-0.2-0.1
Short access day 10 total locomotion0.10.10.80.2-0.20.2-0.1-0.2-0.00.10.2-0.9
Short access total locomotion0.10.11.0-0.10.1-0.10.20.1-0.3-0.2-0.1-1.0
One hour access (0.3 mA shock)0.10.20.7-0.20.3-0.30.30.3-0.5-0.3-0.3-0.9
Compulsive drug intake0.10.10.9-0.10.1-0.10.10.1-0.1-0.1-0.0-0.9
One hour access (shock baseline)0.00.00.1-0.20.2-0.20.20.2-0.2-0.2-0.30.0
Social response proportion0.40.50.80.6-0.60.6-0.8-0.70.90.70.9-0.0
Social responses0.30.30.40.6-0.60.6-0.6-0.60.60.60.5-0.1
Social time0.70.91.0-0.90.9-0.91.01.0-1.0-1.0-0.90.7
Soleus weight3.39.711.63.4-3.43.4-3.2-3.22.93.12.62.7
Bone: stiffness0.20.30.40.5-0.50.5-0.5-0.50.60.50.60.1
Tibialis anterior weight0.00.10.80.2-0.20.2-0.1-0.1-0.00.10.00.9
Time to tail flick, vehicle, before self-admin1.92.02.21.5-1.51.5-1.4-1.51.31.41.41.0
Time to tail flick, vehicle, after self-admin0.60.61.80.7-0.60.6-0.7-0.70.90.70.51.3
Time to tail flick, test, before self-admin0.20.21.80.0-0.00.00.00.0-0.1-0.10.1-1.3
Time to tail flick, test, after self-admin0.20.20.2-0.40.4-0.40.40.4-0.5-0.4-0.40.3
Delta time to tail flick, vehicle, before/after SA0.50.50.8-0.80.8-0.80.70.8-0.5-0.7-0.90.4
Delta time to tail flick, test, before/after SA0.20.20.5-0.40.4-0.40.40.3-0.4-0.3-0.50.7
Tibia length5.515.619.44.4-4.34.3-4.0-4.03.73.93.03.7
Ambulatory time before self-admin0.20.21.4-0.10.1-0.10.10.1-0.3-0.1-0.11.2
Ambulatory time after self-admin0.00.00.0-0.20.2-0.20.10.20.0-0.1-0.1-0.2
Bone: tissue strength3.63.55.11.8-1.81.8-1.8-1.81.91.91.62.3
Total heroin consumption1.21.52.01.2-1.21.2-1.2-1.21.31.21.01.4
Bone: trabecular number0.61.01.6-0.91.0-1.00.91.0-0.8-0.9-1.1-1.2
Bone: trabecular spacing1.41.92.61.3-1.31.3-1.3-1.31.31.31.41.6
Bone: trabecular thickness0.00.00.30.1-0.10.1-0.1-0.00.20.1-0.3-0.5
Bone: trabecular tissue density0.20.30.40.5-0.50.5-0.5-0.50.60.50.4-0.3
Water consumed over 24 hours0.20.21.3-0.10.1-0.10.20.2-0.4-0.2-0.21.2
Number of responses in last shaping day0.50.60.7-0.80.8-0.80.80.8-0.9-0.8-0.80.5