Hub : Genes

Rtp3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Rtp3 0.03 0.03 2.6e-03 0.02 0.02 0 0.01 5.4e-03 6.3e-03 1.2e-01 1.3e-02
2 Liver alternative TSS XM_006243965.5 0.2 0.14 6.2e-12 0.1 0.11 0.11 0.1 1.5e-11 6.9e-12 4.2e-12 1.4e-11
3 Liver alternative TSS NM_001108190.1 0.22 0.15 6.9e-12 0.1 0.11 0.11 0.1 1.3e-11 8.2e-12 6.4e-12 1.2e-11
4 Liver isoform ratio XM_006243965.5 0.18 0.12 5.0e-06 0.04 0.06 0.04 0.05 1.1e-05 1.0e-06 8.6e-05 6.7e-06
5 Liver isoform ratio NM_001108190.1 0.24 0.13 2.6e-07 0.05 0.07 0.05 0.05 1.5e-06 7.2e-08 1.6e-06 1.1e-06
6 Adipose gene expression Rtp3 0.64 0.09 0.0e+00 0.21 0.34 0.34 0.32 1.8e-22 4.7e-39 1.1e-38 1.0e-36
7 Adipose alternative polyA XM_006243965.5 0.45 0.16 4.7e-09 0.04 0.08 0.08 0.04 3.0e-05 1.8e-09 6.5e-09 8.6e-06
8 Liver gene expression Rtp3 0.09 0.09 4.7e-03 0.01 0.01 0.02 0.01 1.3e-02 3.4e-02 2.8e-03 4.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.10.10.5-0.2-0.40.3-0.10.10.2-0.10.7
Area under the delay curve1.51.82.11.41.4-1.41.4-1.4-1.31.21.2
BMI with tail0.20.73.2-1.4-0.40.50.1-0.3-0.20.6-1.8
BMI without tail0.20.72.3-1.5-0.80.9-0.70.70.5-0.3-0.7
Body weight3.917.230.0-5.5-4.64.6-4.03.83.6-2.8-3.7
Weight adjusted by age0.00.00.20.20.00.0-0.10.10.1-0.1-0.5
Bone surface0.10.20.50.30.3-0.40.6-0.6-0.60.70.2
Bone volume0.00.10.20.10.1-0.10.3-0.3-0.30.40.3
Breakpoint value in progressive ratio session0.20.30.60.60.7-0.80.3-0.3-0.40.40.2
Number of licking bursts0.10.20.30.50.6-0.50.3-0.3-0.20.1-0.5
Context. condit. distance diff. score0.00.00.20.0-0.20.20.0-0.1-0.20.3-0.4
Locomotion velocity, session 10.30.40.50.50.7-0.70.4-0.5-0.70.70.6
Locomotion distance, session 10.30.41.0-1.0-0.80.7-0.50.4-0.00.40.0
Locomotion velocity, session 20.60.71.70.50.7-0.70.9-0.9-1.11.3-0.1
Locomotion distance, session 20.40.51.6-0.00.5-0.50.6-0.7-0.91.20.6
Locomotion velocity, session 30.10.10.5-0.4-0.0-0.00.1-0.2-0.50.70.2
Locomotion distance, session 31.21.32.70.50.9-0.91.3-1.3-1.41.60.5
Stereotopy head waving bouts, day 30.20.21.60.00.00.1-0.20.20.2-0.3-1.3
Stereotopy head waving duration, day 30.40.40.9-0.3-0.40.5-0.70.80.8-1.0-0.6
Locomotion velocity, session 70.50.51.0-0.7-0.80.7-0.60.60.6-0.51.0
Locomotion distance, session 70.50.61.20.60.7-0.80.7-0.7-0.70.71.1
Stereotopy head waving bouts, day 70.10.10.40.40.3-0.30.2-0.2-0.20.10.7
Stereotopy head waving duration, day 70.10.10.2-0.3-0.40.4-0.40.40.3-0.20.3
Locomotion velocity, session 80.20.20.7-0.6-0.50.4-0.1-0.0-0.40.8-0.4
Locomotion distance, session 80.20.31.3-0.6-0.20.10.1-0.3-0.71.10.3
Degree of sensitization distance1.61.62.6-0.9-1.21.2-1.51.51.5-1.60.0
Degree of sensitization stereotypy0.10.21.20.20.0-0.10.00.0-0.1-0.11.1
Conditioned locomotion2.42.83.92.01.8-1.81.8-1.7-1.51.31.5
Cocaine response after cond. corrected0.30.41.1-0.5-0.20.2-0.50.50.5-0.7-1.1
Cocaine response after cond. not corrected1.21.42.1-1.4-0.91.0-1.31.21.1-1.2-1.5
Cocaine response before conditioning0.50.61.4-1.2-1.01.0-0.80.70.4-0.1-0.5
Saline control response1.01.41.9-1.0-1.21.1-1.21.31.4-1.40.6
Bone: connectivity density0.20.41.50.70.4-0.40.5-0.4-0.30.21.2
Bone: cortical apparent density0.20.30.50.60.4-0.40.6-0.5-0.70.70.5
Bone: cortical area0.10.20.70.30.4-0.30.3-0.4-0.30.3-0.8
Bone: cortical porosity0.50.53.40.50.4-0.40.1-0.00.2-0.41.8
Bone: cortical porosity0.50.53.20.40.2-0.3-0.10.20.5-0.61.8
Bone: cortical thickness0.30.52.3-0.5-0.50.6-0.40.40.3-0.2-1.5
Bone: cortical thickness0.00.00.0-0.10.0-0.0-0.10.10.1-0.1-0.1
Bone: cortical tissue density0.20.30.50.60.3-0.40.6-0.5-0.70.70.5
Condit. Reinf. active minus inactive responses0.30.30.7-0.2-0.50.5-0.60.70.7-0.8-0.1
Condit. Reinf. active-inactive response ratio0.60.61.1-0.4-0.70.7-0.90.90.9-1.1-0.4
Condit. Reinf. active responses0.00.00.10.30.2-0.2-0.00.10.1-0.30.0
Condit. Reinf. inactive responses0.70.91.30.91.1-1.11.0-1.0-1.00.90.3
Incentive salience index mean0.00.00.10.20.2-0.20.2-0.1-0.20.10.1
Condit. Reinf. lever presses1.42.02.51.21.5-1.51.5-1.6-1.51.60.5
Condit. Reinf. active minus inactive responses1.21.52.5-1.6-1.41.4-1.21.21.0-0.6-1.2
Condit. Reinf. active-inactive response ratio0.91.12.0-1.4-1.01.1-1.01.00.8-0.7-1.1
Condit. Reinf. active responses1.11.52.0-1.4-1.31.3-1.21.21.0-0.8-1.4
Condit. Reinf. inactive responses0.10.10.30.50.2-0.20.2-0.2-0.20.3-0.5
Condit. Reinf. lever presses1.62.23.7-1.9-1.81.7-1.51.41.1-0.7-1.2
Condit. Reinf. lever reinforcers received1.41.92.5-1.6-1.51.5-1.41.41.2-0.9-1.4
Conditioned reinforcement - actives1.72.94.21.72.0-2.01.6-1.7-1.71.90.4
Conditioned reinforcement - inactives2.02.94.41.92.1-2.01.6-1.6-1.71.6-0.6
Conditioned locomotion0.60.81.10.91.0-1.10.7-0.7-0.80.91.0
Patch foraging indifference point 0 sec1.01.82.5-1.6-1.31.3-1.41.41.6-1.40.2
Patch foraging indifference point AUC0.10.21.1-0.2-0.50.4-0.10.10.00.21.0
Delay disc. indifference point, 0s delay0.00.00.1-0.40.0-0.00.0-0.00.2-0.1-0.1
Delay disc. indifference point, 16s delay0.91.01.21.00.9-0.91.1-1.1-1.01.01.0
Delay disc. indifference point, 2s delay0.30.40.50.60.7-0.70.6-0.6-0.60.60.4
Delay disc. indifference point, 24s delay1.11.21.71.31.1-1.11.1-1.0-1.11.10.8
Delay disc. indifference point, 4s delay1.61.62.01.41.3-1.41.4-1.4-1.31.20.6
Delay disc. indifference point, 8s delay1.41.72.21.31.3-1.31.5-1.5-1.21.11.0
Indifference point function ln k0.50.91.50.31.2-1.20.9-0.9-1.01.1-0.8
Indifference point function log k0.50.91.50.31.2-1.20.9-0.9-1.01.1-0.8
Patch foraging total patch changes 0 sec1.02.02.8-1.6-1.41.3-1.51.51.7-1.4-0.0
Patch foraging total patch changes 12 sec0.70.91.2-0.9-1.11.0-1.11.10.9-0.70.2
Patch foraging total patch changes 18 sec2.43.64.7-1.8-2.12.0-2.12.12.2-1.90.5
Patch foraging total patch changes 24 sec1.52.63.6-1.8-1.91.8-1.81.71.5-1.2-0.4
Patch foraging total patch changes 6 sec0.20.41.2-0.4-0.40.3-0.50.50.6-0.51.1
Patch foraging time to switch 0 sec0.20.30.90.90.8-0.80.5-0.4-0.50.2-0.2
Patch foraging water rate 0 sec0.20.30.6-0.7-0.80.7-0.60.50.5-0.2-0.3
Patch foraging water rate 12 sec0.10.20.5-0.7-0.40.5-0.50.50.3-0.2-0.6
Patch foraging water rate 18 sec0.30.42.1-1.0-0.30.40.1-0.1-0.00.1-1.4
Patch foraging water rate 24 sec0.81.21.6-1.3-1.21.2-1.01.01.1-1.1-0.6
Patch foraging water rate 6 sec0.20.30.7-0.8-0.90.8-0.60.50.20.00.1
Seeking ratio, delayed vs. immediate footshock0.81.01.90.80.9-0.91.4-1.4-0.70.70.9
Distance traveled before self-admin0.10.21.1-0.0-0.10.20.4-0.4-0.20.1-1.0
Distance traveled after self-admin0.40.40.90.90.6-0.60.4-0.4-0.90.80.2
Extensor digitorum longus weight0.10.60.80.60.9-0.80.8-0.9-0.70.8-0.3
Bone: elastic displacement0.20.21.1-0.2-0.30.3-0.30.30.4-0.4-1.0
Bone: elastic work0.40.52.6-0.8-0.50.6-0.50.40.20.0-1.6
Bone: endosteal estimation0.10.20.3-0.4-0.30.2-0.50.50.6-0.60.6
Bone: endosteal perimeter1.22.54.01.52.0-2.01.6-1.6-1.51.30.8
Epididymis fat weight0.62.03.0-1.5-1.71.7-1.11.11.4-1.4-1.3
Delta time in closed arm before/after self-admin0.10.10.30.10.1-0.00.6-0.6-0.10.10.5
Delta time in open arm before/after self-admin0.10.10.40.0-0.0-0.1-0.60.6-0.00.00.3
Diff in mean of infusions in LGA sessions0.20.32.1-0.1-0.10.1-0.00.00.1-0.1-1.4
Delay discount exponential model param1.71.92.3-1.4-1.41.4-1.51.51.3-1.3-1.1
Extinction: sum of active levers before priming0.10.20.5-0.7-0.10.1-0.00.00.6-0.50.3
Active lever presses in extinction session 60.40.40.8-0.9-0.70.7-0.40.40.8-0.7-0.2
Bone: final force0.81.21.9-1.4-1.11.1-1.11.10.9-0.7-1.3
Bone: final moment0.91.52.4-1.5-1.11.2-1.21.21.0-0.8-1.5
Food consumed during 24 hour testing period0.91.22.1-1.4-1.01.1-1.21.21.0-0.9-0.9
Glucose0.60.91.4-1.2-1.11.1-1.01.00.8-0.60.3
Heart weight2.13.35.7-2.1-1.92.0-1.51.41.6-1.3-2.4
Delay discount hyperbolic model param2.02.22.6-1.6-1.51.5-1.61.61.5-1.4-1.1
Intermittent access intake day 1-15 change0.51.11.60.91.3-1.21.0-1.1-1.01.0-0.6
Intermittent access intake escalation0.71.52.31.21.5-1.41.2-1.3-1.21.2-0.6
Intermittent access intake escalation 20.40.51.30.50.8-0.70.4-0.4-0.60.6-1.2
Intermitt. access day 1 inactive lever presses0.00.10.30.20.4-0.40.4-0.4-0.20.2-0.6
Intermitt. access day 15 inactive lever presses0.91.92.51.61.6-1.51.5-1.4-1.41.2-0.5
Intermitt. access escalation Index0.20.20.8-0.6-0.40.40.0-0.00.4-0.30.9
Intermittent access day 1 total infusions0.10.20.40.50.4-0.40.6-0.6-0.40.60.2
Intermittent access day 15 total infusions1.01.52.01.21.3-1.31.4-1.4-1.21.3-0.2
Intermittent access terminal intake (last 3 days)0.91.11.51.11.2-1.11.2-1.2-1.11.10.1
Intermittent access total infusions1.21.42.01.11.3-1.21.4-1.4-1.11.3-0.1
Intermittent access day 1 locomotion0.10.10.40.2-0.0-0.0-0.20.2-0.00.10.6
Intermittent access day 15 total locomotion0.40.71.01.01.0-1.00.6-0.7-0.80.90.4
Intermittent access total locomotion1.01.21.41.21.2-1.21.0-1.0-1.11.10.8
Intermittent access standard deviation0.20.52.20.60.6-0.6-0.0-0.0-0.50.5-1.5
Left kidney weight0.52.43.9-2.0-1.81.9-1.51.41.4-1.2-1.0
Right kidney weight0.31.22.7-1.6-1.21.2-0.90.91.1-0.9-0.6
Cocaine induced anxiety0.00.00.10.20.3-0.2-0.10.1-0.10.1-0.3
Post-drug Anxiety0.20.20.40.50.6-0.60.2-0.2-0.40.30.0
Baseline Anxiety0.00.00.10.10.1-0.10.2-0.2-0.10.10.4
Tail length3.915.319.2-4.0-4.44.3-4.44.43.9-3.7-1.3
Length with tail7.633.242.3-6.5-6.46.4-6.05.95.5-5.0-3.9
Length without tail7.122.833.5-5.8-5.35.4-4.64.44.5-3.8-4.1
Times rat made contact with spout0.30.40.5-0.6-0.60.6-0.70.70.7-0.7-0.2
Lifetime Intake1.51.82.31.31.5-1.41.5-1.5-1.31.40.3
Liver weight, left0.71.11.8-1.0-1.31.3-1.01.11.1-1.0-0.2
Liver weight, right1.52.53.9-1.8-2.02.0-1.51.51.5-1.4-0.5
Locomotor activity4.57.09.3-3.1-2.92.8-3.02.92.5-2.2-1.4
Locomotor testing distance3.25.88.2-2.6-2.52.5-2.92.82.2-2.0-1.3
Locomotor testing rearing0.20.40.6-0.4-0.60.6-0.70.70.7-0.8-0.2
Locomotion in novel chamber0.10.20.20.40.5-0.50.4-0.4-0.40.5-0.4
Locomotion in novel chamber post-restriction0.30.50.7-0.9-0.60.5-0.90.80.8-0.60.1
Fecal boli incidents, locomotor time 10.40.61.0-1.0-0.90.9-0.60.60.8-0.6-0.7
Change in fecal boli incidents, locomotor task0.00.00.00.00.1-0.10.0-0.00.0-0.00.2
Time >=10cm from walls, locomotor time 10.20.21.10.40.1-0.10.3-0.2-0.20.01.1
Bouts of movement, locomotor time 10.00.00.1-0.1-0.10.0-0.20.30.1-0.1-0.0
Total resting periods, locomotor time 10.00.00.0-0.2-0.10.1-0.20.20.1-0.1-0.1
Rest time, locomotor task time 10.20.30.50.30.6-0.60.7-0.7-0.30.30.3
Distance moved, locomotor task time 10.71.01.4-1.0-1.01.0-1.21.10.8-0.7-1.0
Vertical activity count, locomotor time 10.20.50.8-0.6-0.70.7-0.90.90.6-0.6-0.4
Time >=10cm from walls, locomotor time 21.01.52.0-1.4-1.41.3-1.21.21.3-1.2-0.5
Bouts of movement, locomotor time 20.10.21.2-0.5-0.00.0-0.0-0.00.20.1-1.1
Total resting periods, locomotor time 20.10.10.8-0.40.2-0.20.2-0.20.00.2-0.9
Rest time, locomotor task time 20.00.00.1-0.10.2-0.20.1-0.2-0.00.10.2
Distance moved, locomotor task time 20.50.60.9-0.7-0.80.8-0.90.90.7-0.8-0.7
Vertical activity count, locomotor time 20.00.00.00.10.1-0.0-0.10.1-0.0-0.0-0.1
Light reinforcement 10.20.40.9-0.9-0.70.7-0.80.80.5-0.5-0.1
Light reinforcement 20.20.30.5-0.00.4-0.40.7-0.7-0.70.60.7
Bone: marrow area0.10.20.4-0.4-0.30.3-0.50.50.6-0.60.6
Bone: maximum diameter0.40.81.20.81.1-1.10.9-0.9-0.90.9-0.2
Bone: maximum force0.50.91.5-1.2-0.90.9-1.11.01.0-0.8-0.7
Bone: maximum moment0.61.01.7-1.3-0.80.9-1.11.11.0-0.9-0.8
Mean time between licks in bursts0.71.62.21.31.5-1.41.3-1.4-1.31.3-0.1
Mean num. licks in bursts0.40.60.8-0.9-0.90.8-0.70.70.7-0.60.5
Cd content in liver0.30.30.60.30.7-0.80.4-0.4-0.40.40.7
Co content in liver0.70.81.41.11.2-1.20.9-0.9-0.70.50.3
Cu content in liver3.03.64.8-2.2-2.02.0-2.12.01.8-1.7-1.2
Fe content in liver1.72.12.7-1.0-1.61.6-1.51.61.6-1.6-0.5
K content in liver0.30.20.6-0.5-0.80.7-0.10.0-0.30.7-0.3
Mg content in liver1.81.85.10.60.7-0.81.4-1.5-1.82.30.1
Mn content in liver0.30.31.5-0.4-0.1-0.00.3-0.4-0.81.20.3
Na content in liver0.90.91.2-0.4-1.11.0-1.11.11.1-1.1-0.1
Rb content in liver2.02.34.7-0.7-1.51.5-1.51.61.9-2.20.0
Se content in liver0.10.10.5-0.1-0.10.10.1-0.1-0.40.5-0.7
Sr content in liver1.31.23.5-0.30.8-0.81.0-1.1-1.51.9-0.3
Zn content in liver1.31.53.0-1.7-1.31.3-1.31.21.1-0.9-0.4
Bone: minimum diameter0.40.71.20.71.1-1.10.9-1.0-0.80.80.1
Time in familiar zone, hab. session 10.40.41.41.20.7-0.70.6-0.6-0.30.10.1
Time in novel zone, hab. session 10.10.10.2-0.3-0.10.1-0.50.50.1-0.2-0.2
Total zone transitions, hab. session 10.10.20.8-0.9-0.30.2-0.40.3-0.10.30.2
Total locomotion distance, hab. session 10.10.10.4-0.7-0.40.4-0.30.30.10.0-0.1
Locomotion velocity, hab. session 10.10.10.5-0.7-0.50.4-0.30.30.10.10.1
Time in familiar zone, hab. session 20.30.30.50.70.4-0.40.6-0.6-0.60.7-0.4
Time in novel zone, hab. session 20.10.10.4-0.10.1-0.1-0.20.30.3-0.50.6
Total zone transitions, hab. session 20.20.20.9-0.40.2-0.20.3-0.4-0.71.0-0.2
Total locomotion distance, hab. session 20.10.20.5-0.7-0.70.6-0.20.20.00.2-0.3
Locomotion velocity, hab. session 20.10.10.3-0.6-0.50.5-0.10.1-0.10.4-0.1
Novel to familiar place preference ratio1.01.01.9-1.1-0.90.8-0.90.91.0-0.91.4
Novelty place preference1.01.12.4-1.1-0.90.8-0.90.91.0-0.91.6
Time in novel zone, NPP test1.21.31.9-1.2-1.11.0-1.11.11.2-1.11.4
Total zone transitions, NPP test0.81.24.6-2.1-1.31.2-1.00.80.40.2-0.7
Total locomotion distance, NPP test0.60.82.0-1.4-1.01.0-0.70.60.5-0.2-0.9
Locomotion velocity, NPP test0.60.82.2-1.5-1.11.1-0.70.60.4-0.1-0.7
Intraocular pressure1.62.24.1-1.0-1.41.4-1.61.61.8-2.00.3
Delta distance traveled before/after self-admin0.20.20.80.50.4-0.4-0.00.0-0.40.40.9
Delta ambulatory time before/after self-admin0.30.30.8-0.2-0.40.3-0.90.90.3-0.30.8
Parametrial fat weight0.30.61.2-1.1-0.80.8-1.01.00.5-0.4-0.5
Pavlov. Cond. lever latency3.84.86.4-2.0-2.22.2-2.52.52.4-2.5-0.5
Pavlov. Cond. magazine entry latency6.58.49.83.13.0-3.03.1-3.1-3.13.11.0
Pavlov. Cond. change in total contacts0.70.81.31.10.7-0.71.1-1.1-0.80.90.4
Pavlov. Cond. index score5.36.78.12.72.6-2.62.8-2.8-2.82.80.7
Pavlov. Cond. latency score5.36.78.32.62.6-2.62.8-2.8-2.82.90.8
Pavlov. Cond. lever contacts2.53.04.31.51.7-1.72.0-2.0-1.92.10.3
Pavlov. Cond. magazine entry number6.27.99.8-3.1-3.03.0-3.03.02.9-2.8-0.9
Pavlov. Cond. intertrial magazine entries0.40.50.7-0.6-0.80.8-0.80.80.8-0.8-0.2
Pavlov. Cond. lever-magazine prob. diff.4.75.87.12.62.4-2.42.6-2.7-2.62.70.4
Pavlov. Cond. response bias5.97.38.82.82.8-2.82.9-3.0-2.92.90.5
Pavlov. Cond. lever latency0.50.61.51.21.0-1.00.7-0.6-0.40.10.7
Pavlov. Cond. magazine entry latency0.40.41.40.10.4-0.40.6-0.7-0.91.2-0.4
Pavlov. Cond. change in total contacts1.82.94.6-2.2-2.12.0-1.71.61.4-0.9-1.4
Pavlov. Cond. index score0.20.30.8-0.8-0.50.5-0.20.1-0.10.5-0.9
Pavlov. Cond. latency score0.20.20.7-0.7-0.30.3-0.1-0.0-0.30.7-0.8
Pavlov. Cond. lever contacts0.60.91.8-1.3-1.21.2-0.90.90.7-0.3-0.5
Pavlov. Cond. magazine entry number0.30.41.4-0.1-0.40.4-0.60.70.8-1.20.2
Pavlov. Cond. intertrial magazine entries0.20.31.11.10.5-0.50.5-0.4-0.1-0.10.8
Pavlov. Cond. lever-magazine prob. diff.0.20.30.8-0.7-0.40.3-0.10.0-0.20.6-0.9
Pavlov. Cond. response bias0.10.20.4-0.6-0.40.4-0.10.0-0.20.6-0.6
Time in closed arm before self-admin0.70.91.2-1.0-1.11.1-1.11.10.9-0.8-0.6
Time in closed arm after self-admin0.00.00.1-0.0-0.10.20.4-0.4-0.00.1-0.0
Time in open arm before self-admin0.60.61.30.90.7-0.61.1-1.1-0.60.50.3
Time in open arm after self-admin0.80.92.90.90.9-1.00.4-0.4-0.70.71.7
Bone: periosteal estimation0.00.00.1-0.2-0.00.0-0.20.10.2-0.2-0.2
Bone: periosteal perimeter0.81.42.41.21.5-1.51.2-1.2-1.11.00.5
Bone: post-yield work0.00.00.1-0.20.3-0.2-0.0-0.0-0.0-0.00.2
Progressive ratio test 1 active lever presses0.10.10.50.10.1-0.1-0.0-0.00.00.10.7
Progressive ratio test 1 breakpoint0.10.10.60.10.1-0.10.0-0.10.00.10.8
Progressive ratio test 1 inactive lever presses0.60.81.41.11.2-1.10.7-0.7-0.90.9-0.5
Progressive ratio test 2 active lever presses1.92.32.91.61.7-1.71.6-1.6-1.51.60.3
Progressive ratio test 2 breakpoint2.02.32.91.61.7-1.71.6-1.7-1.51.60.3
Progressive ratio test 2 inactive lever presses2.03.23.91.92.0-1.91.9-1.9-1.81.9-0.4
Incentive Sensitization - Responses1.72.43.11.51.7-1.61.7-1.7-1.61.5-0.4
Incentive Sensitization - Breakpoint1.92.43.11.61.7-1.71.8-1.8-1.61.6-0.4
Sum of active levers in priming session hrs 5-60.20.21.20.20.3-0.40.0-0.0-0.10.11.1
Progressive ratio1.93.04.2-2.0-1.91.8-1.91.81.8-1.6-0.2
Food seeking constrained by brief footshock0.60.71.40.90.5-0.51.2-1.2-0.90.90.3
Seeking ratio, punishment vs. effort3.24.66.32.32.3-2.22.5-2.5-2.22.10.3
Retroperitoneal fat weight1.25.16.9-2.6-2.52.5-2.32.32.1-1.8-1.7
Reaction time number correct0.20.50.80.80.9-0.90.6-0.6-0.60.50.3
Reaction time mean minus median0.00.00.1-0.10.3-0.3-0.10.1-0.20.2-0.0
Reaction time mean minus median AUC0.10.10.4-0.7-0.20.1-0.40.40.3-0.40.2
Reaction time num false alarms0.20.31.00.70.6-0.60.2-0.2-0.1-0.11.0
Reaction time num false alarms AUC0.10.21.00.40.4-0.40.00.00.2-0.41.0
Reaction time trials correct on left0.20.50.80.80.9-0.90.6-0.6-0.60.50.3
Reaction time trials on left0.30.50.90.81.0-0.90.6-0.6-0.60.50.4
Reaction time mean0.00.00.0-0.10.0-0.0-0.20.20.2-0.2-0.1
Reaction time mean AUC0.00.00.1-0.10.2-0.2-0.10.10.2-0.30.2
Median of all reaction times0.00.00.1-0.0-0.00.0-0.10.10.2-0.3-0.1
Reaction time omissions0.20.41.10.80.5-0.5-0.00.10.3-0.71.1
Reaction time false alarm rate0.10.10.50.10.0-0.1-0.10.20.3-0.40.7
Reaction time premature initiation rate1.21.62.8-1.0-1.31.3-1.61.71.2-1.3-0.4
Reaction time premature initiations0.30.61.3-0.5-0.70.7-1.11.20.6-0.8-0.3
Std. dev. reaction times0.10.10.2-0.4-0.00.0-0.40.40.4-0.40.4
Reaction time trials completed0.30.50.90.81.0-0.90.6-0.6-0.60.50.4
Reaction time trials AUC0.30.61.00.91.0-1.00.7-0.7-0.70.50.4
Run reversals in cocaine runway, females0.80.81.20.91.1-1.01.0-1.0-0.80.5-0.1
Run reversals in cocaine runway, males0.20.20.60.3-0.00.0-0.80.8-0.0-0.1-0.4
Latency to leave start box in cocaine runway0.00.00.1-0.0-0.10.0-0.40.4-0.10.1-0.1
Latency to leave start box in cocaine runway, F0.30.41.2-0.2-0.40.4-0.80.80.2-0.1-1.1
Latency to leave start box in cocaine runway, M0.70.60.90.50.8-0.91.0-0.9-0.70.70.8
Std. dev. time between licks in bursts2.94.05.82.02.4-2.32.1-2.2-2.01.9-0.0
Total sessions with >9 infusions0.40.50.70.80.7-0.60.8-0.8-0.70.6-0.3
Short access day 1 total inactive lever presses2.22.94.11.71.9-1.82.0-2.0-1.61.70.6
Short access day 10 total inactive lever presses0.10.32.1-0.1-0.20.3-0.20.20.1-0.2-1.4
Short access day 1 total infusions2.33.03.71.91.9-1.81.9-1.9-1.71.60.9
Short access day 10 total infusions1.11.52.61.11.1-1.11.6-1.6-1.11.10.7
Short access total infusions2.43.03.91.81.8-1.81.9-2.0-1.71.61.0
Short access day 1 locomotion0.40.60.80.80.7-0.70.9-0.9-0.80.60.3
Short access day 10 total locomotion0.10.10.5-0.2-0.30.3-0.20.20.3-0.20.7
Short access total locomotion0.10.20.70.40.3-0.30.3-0.3-0.30.30.8
One hour access (0.3 mA shock)0.40.50.70.50.9-0.90.7-0.8-0.50.70.7
Compulsive drug intake0.50.61.50.50.7-0.80.8-0.8-0.60.51.2
One hour access (shock baseline)0.30.50.80.70.9-0.80.6-0.7-0.70.9-0.2
Social response proportion0.20.20.5-0.1-0.30.3-0.60.60.5-0.70.2
Social responses0.20.30.4-0.6-0.70.6-0.50.50.4-0.40.4
Social time1.21.62.91.41.7-1.61.0-0.9-1.40.9-0.8
Soleus weight3.19.014.1-3.8-3.43.4-3.23.12.8-2.3-1.7
Bone: stiffness0.10.20.3-0.5-0.40.4-0.50.50.5-0.50.1
Tibialis anterior weight0.00.21.0-0.4-0.00.1-0.10.00.2-0.0-1.0
Time to tail flick, vehicle, before self-admin2.02.12.9-1.7-1.51.5-1.41.41.6-1.5-0.6
Time to tail flick, vehicle, after self-admin0.00.10.10.20.1-0.1-0.30.3-0.20.3-0.2
Time to tail flick, test, before self-admin0.10.21.00.20.2-0.20.3-0.2-0.1-0.11.0
Time to tail flick, test, after self-admin0.10.20.20.40.4-0.40.4-0.5-0.30.4-0.2
Delta time to tail flick, vehicle, before/after SA1.11.01.51.21.1-1.10.8-0.8-1.21.20.3
Delta time to tail flick, test, before/after SA0.10.10.2-0.20.1-0.10.2-0.3-0.10.2-0.4
Tibia length4.712.922.7-4.8-4.34.3-3.53.32.8-2.1-2.7
Ambulatory time before self-admin0.20.30.90.10.10.00.8-0.8-0.30.2-0.9
Ambulatory time after self-admin0.10.10.20.40.1-0.20.1-0.1-0.40.30.4
Bone: tissue strength3.33.34.4-2.0-2.12.1-1.81.81.6-1.4-1.7
Total heroin consumption1.41.73.1-1.2-1.11.2-1.51.51.1-1.0-1.8
Bone: trabecular number0.40.71.50.90.7-0.70.9-0.9-0.70.81.2
Bone: trabecular spacing1.31.72.1-1.3-1.21.3-1.41.41.2-1.3-1.4
Bone: trabecular thickness0.10.10.2-0.3-0.40.30.0-0.0-0.10.40.5
Bone: trabecular tissue density0.10.10.3-0.6-0.50.4-0.50.40.10.00.0
Water consumed over 24 hours0.10.11.0-0.20.1-0.1-0.0-0.0-0.10.0-1.0
Number of responses in last shaping day0.30.32.0-0.10.00.10.4-0.40.00.1-1.4