Hub : Genes

Rptor

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Rptor 0.02 0.02 7.8e-03 0.02 0.01 0 0.01 2.1e-03 1.4e-02 8.4e-02 1.6e-02
2 PL gene expression Rptor 0.03 0.02 1.2e-03 0.03 0.03 0.02 0.03 2.5e-04 7.6e-04 1.3e-03 7.3e-04
3 Brain gene expression Rptor 0.06 0.04 2.0e-05 0.03 0.05 0.04 0.04 4.8e-04 2.4e-05 5.2e-05 6.4e-05
4 pVTA intron excision ratio chr10_105574499_105588290 0.04 0.03 6.7e-03 0.02 0.03 0.01 0.02 6.8e-03 2.7e-03 5.7e-02 1.2e-02
5 NAcc gene expression Rptor 0.02 0.01 3.9e-03 0 0 0.01 0 6.1e-02 1.3e-01 3.9e-02 4.6e-02
6 OFC gene expression Rptor 0.19 0.12 1.5e-03 0.13 0.05 0.06 0.09 5.7e-04 2.7e-02 1.5e-02 3.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bone: apparent density0.00.10.2-0.0-0.4-0.5-0.2-0.2-0.1
Area under the delay curve1.72.03.8-1.61.51.5-1.01.90.7
BMI with tail0.62.13.61.4-1.5-1.80.1-1.2-1.9
BMI without tail2.88.611.53.2-3.2-3.41.6-3.0-2.8
Body weight2.711.716.14.0-4.0-3.63.2-3.1-2.5
Weight adjusted by age2.74.25.42.3-2.2-2.12.1-1.9-1.4
Bone surface0.10.20.60.2-0.40.00.80.20.7
Bone volume0.10.10.30.3-0.5-0.40.4-0.20.2
Breakpoint value in progressive ratio session0.60.81.40.9-0.5-1.10.2-1.2-1.0
Number of licking bursts0.10.20.50.4-0.7-0.40.4-0.6-0.4
Context. condit. distance diff. score0.91.12.90.7-0.8-1.4-0.6-0.7-1.7
Locomotion velocity, session 14.34.67.0-2.22.02.7-0.52.32.4
Locomotion distance, session 11.51.93.7-1.61.71.2-1.91.00.3
Locomotion velocity, session 25.16.08.2-2.92.62.8-1.62.32.3
Locomotion distance, session 20.30.41.4-0.50.50.1-1.2-0.5-0.4
Locomotion velocity, session 31.92.23.1-1.51.61.8-0.61.61.5
Locomotion distance, session 33.13.44.7-2.22.22.0-1.71.61.3
Stereotopy head waving bouts, day 30.40.40.7-0.60.80.8-0.10.70.8
Stereotopy head waving duration, day 30.20.30.5-0.50.70.5-0.30.60.5
Locomotion velocity, session 70.90.91.7-1.01.00.8-1.01.30.5
Locomotion distance, session 72.22.88.3-1.91.80.8-2.90.9-0.4
Stereotopy head waving bouts, day 70.40.40.60.6-0.6-0.60.5-0.6-0.7
Stereotopy head waving duration, day 70.50.61.20.9-0.8-0.61.1-0.5-0.3
Locomotion velocity, session 80.50.61.5-0.60.50.0-1.20.9-0.7
Locomotion distance, session 81.42.04.90.5-0.5-1.7-1.5-1.2-2.2
Degree of sensitization distance1.31.42.50.9-0.9-1.5-0.3-1.2-1.6
Degree of sensitization stereotypy0.70.81.30.8-0.9-1.00.3-1.0-1.1
Conditioned locomotion4.75.47.42.2-2.3-2.61.0-2.7-2.6
Cocaine response after cond. corrected0.10.20.3-0.40.40.3-0.40.50.5
Cocaine response after cond. not corrected0.91.01.5-1.01.01.0-0.71.21.1
Cocaine response before conditioning0.80.91.3-1.00.91.1-0.61.20.8
Saline control response2.22.94.21.8-2.0-1.71.6-1.7-1.2
Bone: connectivity density0.10.10.2-0.40.10.1-0.50.30.1
Bone: cortical apparent density2.33.14.6-2.12.01.7-1.91.51.1
Bone: cortical area4.46.710.73.2-3.1-2.23.3-2.0-1.1
Bone: cortical porosity0.60.72.30.5-0.50.11.50.21.1
Bone: cortical porosity0.80.82.70.9-0.9-0.31.7-0.10.6
Bone: cortical thickness3.96.510.73.0-2.8-2.13.3-2.3-1.1
Bone: cortical thickness1.01.21.81.3-1.3-1.01.3-0.8-0.7
Bone: cortical tissue density2.63.55.1-2.22.11.8-1.91.61.2
Condit. Reinf. active minus inactive responses2.32.63.61.9-1.8-1.81.1-1.7-1.3
Condit. Reinf. active-inactive response ratio1.31.41.91.2-1.1-1.40.4-1.3-1.3
Condit. Reinf. active responses3.84.86.62.6-2.6-2.31.7-2.2-1.5
Condit. Reinf. inactive responses0.81.01.61.2-1.3-1.00.9-1.0-0.5
Incentive salience index mean2.02.43.51.9-1.8-1.61.2-1.6-1.1
Condit. Reinf. lever presses0.30.40.80.6-0.5-0.6-0.0-0.9-0.7
Condit. Reinf. active minus inactive responses0.50.70.90.9-0.9-0.90.7-0.7-0.9
Condit. Reinf. active-inactive response ratio1.61.83.21.6-1.4-1.11.8-1.2-0.5
Condit. Reinf. active responses0.40.51.60.4-0.4-0.8-0.4-0.7-1.3
Condit. Reinf. inactive responses0.70.93.1-0.90.80.2-1.80.2-0.7
Condit. Reinf. lever presses1.21.73.80.6-0.8-1.5-0.9-1.5-1.9
Condit. Reinf. lever reinforcers received0.71.02.90.4-0.5-1.1-0.8-0.9-1.7
Conditioned reinforcement - actives0.00.10.10.2-0.3-0.3-0.20.1-0.0
Conditioned reinforcement - inactives0.71.11.81.1-1.4-1.10.9-0.8-0.9
Conditioned locomotion0.50.61.21.1-0.7-1.10.3-0.7-0.5
Patch foraging indifference point 0 sec0.61.12.70.7-0.7-1.2-0.1-1.6-1.3
Patch foraging indifference point AUC0.00.10.20.1-0.2-0.4-0.1-0.2-0.4
Delay disc. indifference point, 0s delay0.20.20.70.5-0.5-0.10.40.80.1
Delay disc. indifference point, 16s delay1.01.12.7-1.31.10.5-1.60.6-0.6
Delay disc. indifference point, 2s delay0.30.30.6-0.60.60.80.00.70.3
Delay disc. indifference point, 24s delay4.75.37.6-2.82.52.6-1.52.31.8
Delay disc. indifference point, 4s delay0.30.40.8-0.60.80.6-0.20.90.2
Delay disc. indifference point, 8s delay1.92.35.6-1.31.21.8-0.22.41.3
Indifference point function ln k0.50.91.9-1.01.00.7-1.40.90.4
Indifference point function log k0.50.91.9-1.01.00.7-1.40.90.4
Patch foraging total patch changes 0 sec0.81.53.00.7-0.8-1.4-0.4-1.7-1.6
Patch foraging total patch changes 12 sec0.50.72.50.3-0.3-0.80.1-1.6-0.8
Patch foraging total patch changes 18 sec0.81.23.1-0.0-0.1-1.0-1.1-1.3-1.7
Patch foraging total patch changes 24 sec1.32.22.91.6-1.6-1.70.8-1.6-1.4
Patch foraging total patch changes 6 sec0.71.12.91.0-0.9-1.01.0-1.7-0.3
Patch foraging time to switch 0 sec0.61.32.1-1.41.31.4-0.50.91.0
Patch foraging water rate 0 sec3.26.710.02.8-2.7-3.20.9-2.5-2.9
Patch foraging water rate 12 sec0.81.83.90.9-1.1-1.7-0.9-1.0-2.0
Patch foraging water rate 18 sec1.82.95.41.8-1.6-2.3-0.0-1.6-1.9
Patch foraging water rate 24 sec6.28.715.32.5-2.5-3.7-0.4-3.2-3.9
Patch foraging water rate 6 sec0.40.61.20.8-0.9-1.1-0.3-0.1-0.8
Seeking ratio, delayed vs. immediate footshock0.81.01.61.2-1.2-0.71.3-1.0-0.4
Distance traveled before self-admin1.01.31.91.4-1.3-1.11.0-0.9-1.0
Distance traveled after self-admin1.51.83.31.4-1.3-1.8-0.1-1.2-1.6
Extensor digitorum longus weight0.51.84.50.4-0.4-1.5-1.2-1.6-2.1
Bone: elastic displacement1.82.03.01.6-1.6-1.41.1-1.7-1.0
Bone: elastic work5.26.810.53.1-3.1-2.33.2-2.2-0.9
Bone: endosteal estimation0.00.10.4-0.1-0.0-0.2-0.60.2-0.3
Bone: endosteal perimeter0.40.92.41.2-1.1-0.41.60.10.3
Epididymis fat weight1.34.57.32.5-2.4-2.70.9-1.5-2.2
Delta time in closed arm before/after self-admin0.00.00.1-0.0-0.0-0.10.2-0.3-0.1
Delta time in open arm before/after self-admin0.20.20.40.4-0.4-0.6-0.1-0.6-0.6
Diff in mean of infusions in LGA sessions0.30.41.30.3-0.3-0.40.6-1.1-0.6
Delay discount exponential model param2.62.94.52.0-1.9-1.81.1-2.1-0.9
Extinction: sum of active levers before priming0.40.40.6-0.60.70.3-0.80.80.5
Active lever presses in extinction session 60.10.10.4-0.10.60.10.1-0.4-0.2
Bone: final force4.57.211.23.2-3.3-2.62.9-2.1-1.5
Bone: final moment5.38.612.83.5-3.6-2.93.1-2.4-1.6
Food consumed during 24 hour testing period1.11.52.51.2-1.1-1.40.4-1.3-1.6
Glucose8.112.817.3-3.43.94.2-1.33.84.0
Heart weight0.50.81.61.3-1.0-0.81.0-0.5-0.2
Delay discount hyperbolic model param2.22.53.91.8-1.8-1.71.0-2.0-0.9
Intermittent access intake day 1-15 change0.00.10.10.1-0.1-0.10.40.4-0.1
Intermittent access intake escalation0.00.00.10.1-0.0-0.10.30.4-0.0
Intermittent access intake escalation 20.20.20.70.4-0.4-0.20.90.20.1
Intermitt. access day 1 inactive lever presses1.34.97.32.3-2.3-2.70.9-2.2-2.4
Intermitt. access day 15 inactive lever presses1.22.43.41.6-1.8-1.90.3-1.6-1.7
Intermitt. access escalation Index0.81.12.21.1-1.1-1.00.6-1.5-0.8
Intermittent access day 1 total infusions0.10.10.30.5-0.3-0.50.00.1-0.0
Intermittent access day 15 total infusions0.20.30.60.8-0.6-0.80.6-0.0-0.3
Intermittent access terminal intake (last 3 days)0.40.50.91.0-0.9-0.80.80.1-0.2
Intermittent access total infusions0.20.20.50.7-0.5-0.60.30.1-0.2
Intermittent access day 1 locomotion0.20.20.40.5-0.5-0.60.2-0.6-0.2
Intermittent access day 15 total locomotion0.30.61.01.0-0.9-0.90.8-0.2-0.5
Intermittent access total locomotion0.30.40.60.8-0.7-0.80.5-0.2-0.5
Intermittent access standard deviation0.20.51.5-0.40.60.80.01.20.5
Left kidney weight0.10.41.40.4-0.10.21.20.60.9
Right kidney weight0.10.31.00.40.10.21.00.30.8
Cocaine induced anxiety0.91.23.41.1-1.1-0.61.8-1.1-0.2
Post-drug Anxiety0.10.10.2-0.20.20.10.4-0.3-0.1
Baseline Anxiety1.82.13.2-1.81.81.3-1.61.30.7
Tail length3.413.319.04.4-4.0-3.54.0-3.5-1.9
Length with tail1.87.918.23.4-3.1-2.04.3-2.1-0.3
Length without tail0.41.35.21.0-1.0-0.12.3-0.20.8
Times rat made contact with spout1.21.42.01.3-1.2-1.11.4-1.4-0.5
Lifetime Intake0.00.00.10.3-0.1-0.3-0.10.3-0.0
Liver weight, left0.71.12.0-0.81.01.20.11.21.4
Liver weight, right3.25.58.22.9-2.6-2.22.7-2.3-1.1
Locomotor activity0.40.71.1-0.70.90.7-0.91.10.6
Locomotor testing distance0.40.71.8-0.70.90.5-1.30.80.0
Locomotor testing rearing0.40.82.20.3-0.1-0.8-1.0-0.9-1.5
Locomotion in novel chamber0.10.10.30.3-0.4-0.60.0-0.3-0.3
Locomotion in novel chamber post-restriction1.01.62.51.3-1.6-1.21.4-1.3-0.4
Fecal boli incidents, locomotor time 10.20.30.5-0.20.70.5-0.50.60.4
Change in fecal boli incidents, locomotor task2.92.94.8-2.21.81.9-1.01.41.6
Time >=10cm from walls, locomotor time 10.30.31.20.1-0.4-0.5-0.6-0.2-1.1
Bouts of movement, locomotor time 12.02.33.0-1.61.71.4-1.31.61.1
Total resting periods, locomotor time 12.73.04.2-1.82.01.7-1.31.81.6
Rest time, locomotor task time 11.01.33.2-0.81.01.20.01.21.8
Distance moved, locomotor task time 10.81.22.50.7-1.0-1.00.6-1.6-1.5
Vertical activity count, locomotor time 10.82.03.31.1-1.6-1.50.3-1.7-1.8
Time >=10cm from walls, locomotor time 20.10.10.50.10.10.00.4-0.7-0.1
Bouts of movement, locomotor time 20.91.41.8-1.31.31.2-1.21.00.8
Total resting periods, locomotor time 20.40.71.0-1.00.90.8-1.00.80.6
Rest time, locomotor task time 20.20.30.7-0.50.40.5-0.00.60.9
Distance moved, locomotor task time 20.40.41.30.5-0.3-0.30.7-1.1-0.7
Vertical activity count, locomotor time 20.30.51.10.6-0.5-0.60.0-0.9-1.1
Light reinforcement 11.64.05.82.0-1.9-2.40.4-2.4-2.1
Light reinforcement 22.23.34.72.1-2.2-1.91.5-1.9-1.3
Bone: marrow area0.10.10.5-0.10.0-0.2-0.70.2-0.4
Bone: maximum diameter1.22.25.51.9-1.8-0.82.3-0.4-0.1
Bone: maximum force4.27.511.33.2-3.4-2.72.9-2.3-1.6
Bone: maximum moment4.88.512.43.4-3.5-2.93.0-2.6-1.7
Mean time between licks in bursts0.71.62.3-1.51.51.3-1.01.30.8
Mean num. licks in bursts0.10.20.50.6-0.1-0.60.3-0.7-0.3
Cd content in liver0.91.02.7-0.40.5-0.6-1.7-0.7-1.4
Co content in liver0.10.10.20.3-0.5-0.20.30.00.1
Cu content in liver0.50.61.51.0-0.9-0.51.2-0.4-0.0
Fe content in liver0.20.20.8-0.30.4-0.2-0.90.0-0.5
K content in liver2.01.92.41.6-1.6-1.50.8-1.4-1.3
Mg content in liver0.80.81.40.7-0.8-1.1-0.3-0.9-1.2
Mn content in liver0.10.10.20.3-0.5-0.10.5-0.1-0.4
Na content in liver0.00.00.10.3-0.2-0.20.0-0.1-0.1
Rb content in liver2.73.25.21.7-1.7-2.20.3-1.8-2.3
Se content in liver0.60.71.70.6-0.8-1.0-0.1-0.9-1.3
Sr content in liver0.40.31.1-0.40.40.70.20.31.0
Zn content in liver1.11.22.01.4-1.4-1.01.3-0.9-0.3
Bone: minimum diameter3.15.78.83.0-2.7-2.32.6-2.1-1.3
Time in familiar zone, hab. session 10.10.10.2-0.40.3-0.1-0.5-0.0-0.0
Time in novel zone, hab. session 10.10.10.50.2-0.20.00.20.70.2
Total zone transitions, hab. session 10.20.31.3-0.40.5-0.1-1.1-0.2-0.4
Total locomotion distance, hab. session 10.60.81.70.8-0.5-1.3-0.6-0.7-1.2
Locomotion velocity, hab. session 10.71.01.80.9-0.6-1.3-0.4-1.1-1.3
Time in familiar zone, hab. session 20.30.31.1-0.60.4-0.0-1.1-0.0-0.3
Time in novel zone, hab. session 20.10.10.2-0.10.20.40.30.50.3
Total zone transitions, hab. session 20.70.92.0-0.10.1-0.8-1.4-1.0-1.4
Total locomotion distance, hab. session 21.41.82.91.1-0.9-1.6-0.5-1.7-1.6
Locomotion velocity, hab. session 21.62.13.31.4-1.2-1.8-0.2-1.8-1.6
Novel to familiar place preference ratio2.62.95.71.6-1.7-1.71.1-2.4-1.4
Novelty place preference2.42.54.91.5-1.7-1.61.1-2.2-1.2
Time in novel zone, NPP test2.22.44.91.4-1.5-1.60.9-2.2-1.4
Total zone transitions, NPP test0.50.72.2-0.20.3-0.5-1.5-0.5-1.1
Total locomotion distance, NPP test1.41.93.70.7-0.6-1.6-1.1-1.7-1.9
Locomotion velocity, NPP test1.31.83.20.9-0.8-1.6-0.8-1.7-1.8
Intraocular pressure0.50.81.60.6-0.8-1.2-0.0-1.0-1.0
Delta distance traveled before/after self-admin0.20.31.10.00.1-0.5-1.00.1-0.4
Delta ambulatory time before/after self-admin0.50.62.3-0.70.70.1-1.50.70.1
Parametrial fat weight0.61.42.21.3-1.2-1.50.7-1.1-1.1
Pavlov. Cond. lever latency1.41.86.4-1.11.1-0.1-2.50.7-1.1
Pavlov. Cond. magazine entry latency1.72.25.41.8-1.6-0.82.3-1.1-0.2
Pavlov. Cond. change in total contacts0.20.20.60.4-0.4-0.10.8-0.40.4
Pavlov. Cond. index score2.93.78.22.2-2.1-1.22.9-1.7-0.2
Pavlov. Cond. latency score2.33.08.41.9-1.8-0.72.9-1.30.3
Pavlov. Cond. lever contacts1.11.33.81.1-1.2-0.31.9-1.00.6
Pavlov. Cond. magazine entry number1.51.95.8-1.61.50.6-2.40.9-0.2
Pavlov. Cond. intertrial magazine entries0.30.30.60.4-0.5-0.8-0.5-0.5-0.7
Pavlov. Cond. lever-magazine prob. diff.2.93.67.12.2-2.1-1.32.7-1.8-0.4
Pavlov. Cond. response bias1.41.85.51.5-1.4-0.52.3-0.80.4
Pavlov. Cond. lever latency2.33.25.2-1.41.52.20.22.22.3
Pavlov. Cond. magazine entry latency1.11.45.2-1.01.1-0.1-2.30.0-0.9
Pavlov. Cond. change in total contacts0.60.92.7-0.20.0-0.8-1.6-0.8-1.3
Pavlov. Cond. index score0.91.22.70.1-0.1-1.1-1.4-1.1-1.6
Pavlov. Cond. latency score0.91.22.80.2-0.2-1.1-1.4-1.1-1.7
Pavlov. Cond. lever contacts2.02.84.91.2-1.3-2.0-0.5-2.1-2.2
Pavlov. Cond. magazine entry number0.81.04.10.7-0.70.32.00.20.9
Pavlov. Cond. intertrial magazine entries1.32.02.81.6-1.7-1.41.3-1.2-1.3
Pavlov. Cond. lever-magazine prob. diff.0.81.02.7-0.10.1-0.9-1.6-0.8-1.4
Pavlov. Cond. response bias1.11.42.90.4-0.4-1.3-1.2-1.4-1.7
Time in closed arm before self-admin0.91.11.7-1.11.31.2-0.30.91.1
Time in closed arm after self-admin1.81.92.9-1.71.71.6-0.41.11.3
Time in open arm before self-admin0.20.20.60.5-0.8-0.30.5-0.4-0.4
Time in open arm after self-admin0.30.30.60.5-0.7-0.7-0.2-0.3-0.8
Bone: periosteal estimation1.22.54.02.0-1.9-1.51.8-1.0-0.8
Bone: periosteal perimeter2.34.012.52.4-2.2-0.83.5-0.50.6
Bone: post-yield work0.00.00.1-0.10.1-0.1-0.2-0.10.0
Progressive ratio test 1 active lever presses0.20.30.50.6-0.6-0.7-0.0-0.4-0.5
Progressive ratio test 1 breakpoint0.20.30.50.6-0.6-0.70.1-0.5-0.4
Progressive ratio test 1 inactive lever presses4.36.28.02.7-2.6-2.81.1-2.7-2.6
Progressive ratio test 2 active lever presses0.10.20.40.4-0.3-0.7-0.1-0.0-0.5
Progressive ratio test 2 breakpoint0.10.20.40.4-0.3-0.7-0.10.0-0.5
Progressive ratio test 2 inactive lever presses0.30.50.80.9-0.8-0.90.7-0.4-0.6
Incentive Sensitization - Responses0.10.10.50.2-0.1-0.30.10.7-0.0
Incentive Sensitization - Breakpoint0.10.10.50.3-0.1-0.30.10.7-0.0
Sum of active levers in priming session hrs 5-60.30.20.50.5-0.3-0.7-0.5-0.3-0.6
Progressive ratio0.40.71.2-1.10.80.8-0.90.40.8
Food seeking constrained by brief footshock0.20.20.3-0.50.50.5-0.20.40.4
Seeking ratio, punishment vs. effort0.10.10.40.4-0.3-0.30.10.2-0.6
Retroperitoneal fat weight4.218.126.34.8-4.5-5.12.2-3.8-4.4
Reaction time number correct1.73.37.31.0-1.2-2.3-1.7-1.3-2.7
Reaction time mean minus median0.20.40.7-0.50.60.90.40.30.9
Reaction time mean minus median AUC0.10.21.00.3-0.20.21.0-0.50.2
Reaction time num false alarms0.30.40.6-0.70.80.5-0.60.70.6
Reaction time num false alarms AUC0.50.81.3-1.01.10.7-0.80.80.6
Reaction time trials correct on left1.73.37.31.0-1.2-2.3-1.7-1.3-2.7
Reaction time trials on left1.83.47.61.1-1.3-2.3-1.7-1.3-2.8
Reaction time mean0.20.40.70.5-0.5-0.60.0-0.8-0.8
Reaction time mean AUC0.30.51.00.5-0.6-0.8-0.1-0.9-1.0
Median of all reaction times0.40.61.20.6-0.7-0.9-0.1-0.8-1.1
Reaction time omissions0.30.50.60.8-0.8-0.60.7-0.8-0.7
Reaction time false alarm rate1.72.43.8-1.51.61.80.01.52.0
Reaction time premature initiation rate1.11.63.0-1.71.41.1-1.60.80.5
Reaction time premature initiations0.81.45.5-0.90.5-0.3-2.4-0.2-1.2
Std. dev. reaction times0.20.30.7-0.70.80.6-0.70.1-0.0
Reaction time trials completed1.83.47.61.1-1.3-2.3-1.7-1.3-2.8
Reaction time trials AUC1.93.67.91.1-1.3-2.4-1.7-1.5-2.8
Run reversals in cocaine runway, females1.01.02.9-1.11.00.4-1.70.5-0.3
Run reversals in cocaine runway, males0.60.61.60.8-0.9-0.41.3-0.30.4
Latency to leave start box in cocaine runway0.50.61.0-0.80.90.7-1.00.40.7
Latency to leave start box in cocaine runway, F0.20.20.9-0.20.4-0.3-1.0-0.2-0.4
Latency to leave start box in cocaine runway, M0.80.71.7-0.70.71.0-0.40.51.3
Std. dev. time between licks in bursts1.31.74.20.8-0.8-1.6-0.6-1.3-2.1
Total sessions with >9 infusions0.30.30.4-0.50.60.5-0.60.60.5
Short access day 1 total inactive lever presses0.10.20.40.6-0.4-0.30.5-0.1-0.4
Short access day 10 total inactive lever presses2.25.46.42.4-2.5-2.51.7-2.3-2.4
Short access day 1 total infusions1.01.42.2-1.41.41.0-1.51.00.4
Short access day 10 total infusions0.81.01.91.4-1.2-1.10.9-0.7-0.4
Short access total infusions0.10.10.30.10.1-0.2-0.50.1-0.2
Short access day 1 locomotion0.50.71.2-0.80.50.9-0.31.01.1
Short access day 10 total locomotion0.20.41.3-0.40.40.80.40.21.1
Short access total locomotion0.40.41.5-0.30.20.70.40.51.2
One hour access (0.3 mA shock)0.20.20.60.4-0.3-0.8-0.4-0.2-0.6
Compulsive drug intake0.50.61.10.8-0.9-1.00.2-0.7-0.9
One hour access (shock baseline)0.00.00.10.2-0.1-0.20.20.30.3
Social response proportion0.20.20.6-0.20.1-0.1-0.6-0.3-0.8
Social responses0.20.30.90.2-0.2-0.5-0.1-0.7-0.9
Social time0.10.20.6-0.00.1-0.2-0.5-0.4-0.8
Soleus weight1.33.95.82.4-2.3-1.72.3-1.7-0.8
Bone: stiffness0.20.40.80.7-0.8-0.50.9-0.2-0.2
Tibialis anterior weight0.00.00.1-0.30.10.1-0.3-0.1-0.0
Time to tail flick, vehicle, before self-admin0.50.51.4-0.50.60.70.10.51.2
Time to tail flick, vehicle, after self-admin1.01.32.6-1.31.41.6-0.30.61.0
Time to tail flick, test, before self-admin0.50.51.1-1.00.70.9-0.20.40.6
Time to tail flick, test, after self-admin0.90.91.3-1.01.11.10.01.01.0
Delta time to tail flick, vehicle, before/after SA0.50.51.30.5-0.5-0.60.1-0.8-1.1
Delta time to tail flick, test, before/after SA0.50.50.9-0.50.80.8-0.10.90.6
Tibia length6.518.037.15.2-5.2-3.06.1-2.2-1.3
Ambulatory time before self-admin2.23.34.72.2-2.0-1.91.5-1.5-1.7
Ambulatory time after self-admin1.51.83.01.4-1.1-1.7-0.1-1.2-1.7
Bone: tissue strength3.33.45.71.8-1.7-2.11.0-2.4-1.7
Total heroin consumption0.20.20.40.6-0.3-0.30.4-0.6-0.6
Bone: trabecular number0.20.30.9-0.60.20.50.10.70.9
Bone: trabecular spacing2.22.97.81.2-0.9-2.0-0.9-1.6-2.8
Bone: trabecular thickness0.50.72.10.1-0.30.31.30.21.5
Bone: trabecular tissue density0.71.11.5-1.01.01.2-0.61.21.0
Water consumed over 24 hours0.10.20.5-0.10.10.30.60.00.7
Number of responses in last shaping day0.20.20.40.4-0.60.10.6-0.40.5