Hub : Genes

Rpl36a-ps18

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Rpl36a-ps18	0.1	0.06	6.3e-06	0.04	0.06	0.03	0.04	2.0e-04	4.7e-06	3.5e-04	7.7e-05
2	PL	gene expression	Rpl36a-ps18	0.14	0.05	1.8e-13	0.15	0.12	0.12	0.14	1.2e-15	6.7e-13	8.1e-13	1.0e-14
3	IC	gene expression	Rpl36a-ps18	0.1	0.05	2.2e-03	0.08	0.04	0.04	0.06	3.2e-04	1.2e-02	1.1e-02	1.5e-03
4	NAcc	gene expression	Rpl36a-ps18	0.04	0.02	3.0e-07	0.05	0.04	0.05	0.05	1.2e-08	2.1e-07	3.7e-08	3.7e-08
5	BLA	gene expression	Rpl36a-ps18	0.13	0.06	1.7e-06	0.13	0.12	0.13	0.12	1.8e-07	4.4e-07	2.8e-07	7.6e-07
6	RMTg	alternative TSS	XR_010053684.1	0.32	0.13	8.4e-04	0.13	0.09	0.07	0.11	3.0e-04	2.5e-03	5.4e-03	7.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.1	0.2	0.8	0.1	-0.4	-0.5	0.0	-0.0	0.9
Area under the delay curve	1.3	1.9	3.4	-1.3	1.8	1.1	1.8	1.4	-0.1
BMI with tail	0.1	0.2	1.3	1.1	-0.0	0.2	-0.0	-0.0	0.2
BMI without tail	0.8	4.3	11.9	3.5	-1.7	-1.9	-2.0	-1.9	-0.3
Body weight	2.8	12.5	32.0	5.7	-3.2	-3.4	-3.2	-3.3	-0.2
Weight adjusted by age	0.3	0.9	3.5	-0.5	-0.6	-0.7	-0.6	-0.6	1.9
Bone surface	0.1	0.1	0.3	0.6	0.1	-0.2	0.2	0.3	0.3
Bone volume	0.1	0.1	0.5	0.4	-0.1	-0.3	0.2	0.2	0.7
Breakpoint value in progressive ratio session	1.3	2.3	4.4	-2.1	1.5	1.4	1.6	1.6	0.5
Number of licking bursts	0.1	0.2	1.0	0.5	-0.2	-0.1	-0.1	-0.1	1.0
Context. condit. distance diff. score	0.4	0.5	2.1	0.8	-0.0	0.4	0.0	0.2	-1.5
Locomotion velocity, session 1	0.5	0.5	1.5	-1.2	0.3	0.0	0.2	0.2	1.2
Locomotion distance, session 1	0.2	0.3	1.0	-0.8	0.2	0.3	0.2	0.2	1.0
Locomotion velocity, session 2	0.1	0.2	0.7	0.1	-0.2	-0.4	-0.1	-0.1	-0.9
Locomotion distance, session 2	0.1	0.2	1.0	-0.3	0.1	-0.0	0.2	0.2	1.0
Locomotion velocity, session 3	0.1	0.1	0.2	-0.5	0.1	-0.2	0.1	0.2	-0.5
Locomotion distance, session 3	0.2	0.2	0.4	-0.4	0.4	0.5	0.6	0.6	-0.2
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	-0.2	0.0	-0.3	0.0	-0.1	0.2
Stereotopy head waving duration, day 3	0.1	0.2	0.6	0.0	-0.2	-0.8	-0.4	-0.5	0.3
Locomotion velocity, session 7	0.1	0.1	0.3	-0.5	-0.1	0.4	0.0	0.2	0.5
Locomotion distance, session 7	0.2	0.3	0.7	-0.8	0.4	0.7	0.4	0.5	0.1
Stereotopy head waving bouts, day 7	0.5	0.6	0.8	0.1	-0.7	-0.9	-0.8	-0.9	0.8
Stereotopy head waving duration, day 7	0.4	0.5	1.3	-0.2	-0.5	-0.8	-0.6	-0.6	1.1
Locomotion velocity, session 8	0.5	0.6	0.9	0.8	-0.7	-0.7	-0.7	-0.6	-1.0
Locomotion distance, session 8	0.1	0.2	0.7	0.8	-0.2	-0.0	-0.1	-0.0	-0.5
Degree of sensitization distance	0.1	0.1	0.2	-0.3	0.3	0.5	0.2	0.2	-0.3
Degree of sensitization stereotypy	0.1	0.1	0.2	-0.3	-0.3	-0.3	-0.4	-0.4	0.4
Conditioned locomotion	0.1	0.1	0.5	0.1	0.1	0.4	0.2	0.2	-0.7
Cocaine response after cond. corrected	0.1	0.2	0.7	0.9	0.1	-0.4	-0.2	-0.4	-0.4
Cocaine response after cond. not corrected	0.1	0.2	0.7	0.8	-0.0	-0.5	-0.3	-0.4	-0.1
Cocaine response before conditioning	0.0	0.0	0.1	-0.3	-0.2	0.0	-0.0	-0.0	0.3
Saline control response	0.6	0.8	1.1	0.9	-0.9	-0.9	-1.0	-1.0	0.4
Bone: connectivity density	0.1	0.2	0.5	0.4	-0.5	-0.7	-0.1	-0.2	0.4
Bone: cortical apparent density	0.1	0.2	0.8	0.3	-0.9	-0.1	-0.5	-0.4	0.0
Bone: cortical area	0.1	0.1	0.3	0.6	-0.1	-0.3	-0.2	-0.2	0.5
Bone: cortical porosity	0.1	0.1	0.3	0.4	-0.2	-0.5	-0.0	-0.2	-0.5
Bone: cortical porosity	0.0	0.0	0.1	0.0	0.0	-0.4	0.1	-0.0	-0.0
Bone: cortical thickness	0.2	0.4	0.5	0.4	-0.6	-0.7	-0.6	-0.7	0.6
Bone: cortical thickness	0.1	0.1	0.3	-0.6	0.4	0.1	0.2	0.2	0.3
Bone: cortical tissue density	0.2	0.3	0.9	0.4	-1.0	-0.2	-0.6	-0.5	-0.0
Condit. Reinf. active minus inactive responses	0.8	1.0	2.7	-1.6	0.3	0.8	0.5	0.6	1.3
Condit. Reinf. active-inactive response ratio	0.9	1.0	2.4	-1.6	0.6	0.9	0.6	0.7	1.1
Condit. Reinf. active responses	1.1	1.4	3.5	-1.9	0.3	0.8	0.7	0.7	1.7
Condit. Reinf. inactive responses	0.4	0.6	1.4	-1.2	0.4	0.6	0.7	0.6	0.8
Incentive salience index mean	1.0	1.2	5.8	-1.2	-0.4	0.1	-0.1	-0.1	2.4
Condit. Reinf. lever presses	0.9	1.3	6.2	-0.5	-0.8	-0.5	-0.6	-0.6	2.5
Condit. Reinf. active minus inactive responses	0.5	0.8	2.5	-1.5	0.2	0.3	0.2	0.4	1.6
Condit. Reinf. active-inactive response ratio	0.2	0.3	1.2	-0.6	-0.2	-0.4	-0.4	-0.4	1.1
Condit. Reinf. active responses	0.5	0.8	1.9	-1.4	0.4	0.6	0.5	0.7	1.2
Condit. Reinf. inactive responses	0.7	1.1	1.6	-1.2	0.9	1.3	1.2	1.2	-0.1
Condit. Reinf. lever presses	0.2	0.3	0.9	-1.0	0.0	0.2	0.1	0.2	0.8
Condit. Reinf. lever reinforcers received	0.7	0.9	2.3	-1.5	0.6	0.9	0.7	0.8	1.1
Conditioned reinforcement - actives	0.5	1.9	3.3	0.7	-1.3	-1.5	-1.3	-1.4	1.8
Conditioned reinforcement - inactives	0.1	0.3	0.4	0.4	-0.6	-0.6	-0.6	-0.6	0.2
Conditioned locomotion	0.6	0.9	1.3	0.7	-1.0	-1.1	-1.0	-1.1	0.5
Patch foraging indifference point 0 sec	0.1	0.2	0.3	0.4	-0.5	-0.5	-0.3	-0.3	0.3
Patch foraging indifference point AUC	0.4	1.0	1.4	1.0	-1.2	-1.2	-1.0	-1.1	0.4
Delay disc. indifference point, 0s delay	0.5	0.6	1.4	-1.2	0.6	0.3	0.4	0.4	1.2
Delay disc. indifference point, 16s delay	1.8	2.6	4.7	-1.2	2.0	1.5	2.2	1.7	-0.4
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.3	0.5	0.1	0.4	-0.0	0.1
Delay disc. indifference point, 24s delay	0.5	0.8	1.3	-0.1	1.1	0.6	1.2	1.0	-0.9
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.4	0.5	-0.1	0.3	-0.1	0.1
Delay disc. indifference point, 8s delay	1.3	2.2	3.7	-1.3	1.9	1.3	1.9	1.5	-0.3
Indifference point function ln k	0.3	0.8	1.3	-0.4	0.8	0.9	0.9	1.0	-1.1
Indifference point function log k	0.3	0.8	1.3	-0.4	0.8	0.9	0.9	1.0	-1.1
Patch foraging total patch changes 0 sec	0.1	0.2	0.3	0.4	-0.5	-0.5	-0.3	-0.4	0.3
Patch foraging total patch changes 12 sec	2.3	3.0	4.3	1.1	-1.9	-1.8	-1.7	-1.7	2.1
Patch foraging total patch changes 18 sec	1.6	3.8	4.9	1.9	-2.2	-2.1	-2.2	-2.1	0.6
Patch foraging total patch changes 24 sec	0.8	2.7	4.1	1.6	-1.7	-2.0	-1.8	-1.7	0.6
Patch foraging total patch changes 6 sec	0.2	0.3	0.7	0.5	-0.6	-0.6	-0.3	-0.3	0.8
Patch foraging time to switch 0 sec	0.0	0.1	0.2	0.2	-0.1	-0.1	-0.4	-0.4	0.4
Patch foraging water rate 0 sec	0.1	0.2	0.7	0.6	-0.5	-0.3	-0.2	-0.2	0.8
Patch foraging water rate 12 sec	0.6	2.3	4.2	2.1	-1.4	-1.6	-1.6	-1.5	0.7
Patch foraging water rate 18 sec	0.1	0.1	0.4	-0.1	0.3	0.4	0.5	0.6	-0.1
Patch foraging water rate 24 sec	0.2	0.3	1.0	1.0	-0.5	-0.4	-0.4	-0.3	0.0
Patch foraging water rate 6 sec	1.0	1.5	4.1	2.0	-0.9	-1.0	-1.2	-1.1	0.4
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.6	-0.4	0.2	-0.1	-0.1	-0.2	0.8
Distance traveled before self-admin	0.0	0.1	0.3	-0.3	0.3	0.2	0.2	0.1	0.6
Distance traveled after self-admin	1.1	1.9	2.8	-1.5	1.7	1.3	1.6	1.5	-0.6
Extensor digitorum longus weight	0.0	0.1	0.5	0.7	0.2	-0.2	0.1	0.1	-0.5
Bone: elastic displacement	1.4	1.7	3.6	-1.9	1.3	1.2	1.2	1.3	-0.8
Bone: elastic work	0.9	1.2	2.1	-1.4	1.1	0.9	1.0	1.0	-0.9
Bone: endosteal estimation	1.4	3.4	4.9	-0.5	2.2	2.0	2.1	2.2	-1.4
Bone: endosteal perimeter	0.3	0.8	1.0	0.8	1.0	0.8	0.8	0.8	-1.0
Epididymis fat weight	0.1	0.7	1.6	1.3	-0.7	-0.4	-0.6	-0.6	1.1
Delta time in closed arm before/after self-admin	0.1	0.1	0.4	0.4	-0.0	-0.1	0.0	-0.1	-0.6
Delta time in open arm before/after self-admin	1.0	1.2	2.5	-1.6	1.0	1.0	0.9	1.0	0.9
Diff in mean of infusions in LGA sessions	0.3	0.6	2.0	-1.2	0.1	0.1	0.2	0.2	1.4
Delay discount exponential model param	1.1	1.4	2.7	1.0	-1.6	-1.0	-1.6	-1.2	0.3
Extinction: sum of active levers before priming	0.2	0.3	0.5	-0.7	0.5	0.6	0.6	0.7	-0.1
Active lever presses in extinction session 6	0.7	0.7	1.6	-1.3	0.7	0.7	0.9	0.9	0.3
Bone: final force	0.3	0.6	0.9	-0.4	1.0	0.8	0.9	0.9	-0.1
Bone: final moment	0.3	0.4	0.7	-0.5	0.8	0.6	0.8	0.8	0.3
Food consumed during 24 hour testing period	0.6	1.1	2.2	1.5	-1.1	-0.9	-1.0	-0.9	-0.7
Glucose	0.0	0.0	0.2	-0.2	0.1	-0.1	-0.0	0.0	-0.4
Heart weight	0.2	0.3	0.6	-0.2	0.8	0.5	0.7	0.6	0.6
Delay discount hyperbolic model param	0.9	1.1	2.2	0.9	-1.5	-0.8	-1.5	-1.0	0.2
Intermittent access intake day 1-15 change	0.6	3.3	4.2	1.3	-2.0	-1.8	-1.8	-1.9	2.0
Intermittent access intake escalation	0.6	3.1	4.4	1.2	-1.9	-1.7	-1.8	-1.8	2.1
Intermittent access intake escalation 2	0.8	1.4	1.9	1.1	-1.4	-1.2	-1.3	-1.3	0.7
Intermitt. access day 1 inactive lever presses	0.0	0.6	1.4	-1.2	0.5	0.8	0.6	0.6	-0.9
Intermitt. access day 15 inactive lever presses	0.1	0.5	2.5	-0.4	0.2	0.3	0.2	0.1	-1.6
Intermitt. access escalation Index	0.1	0.2	0.3	-0.5	0.3	0.4	0.4	0.5	0.3
Intermittent access day 1 total infusions	0.4	1.1	3.5	1.9	-0.6	-0.8	-0.5	-0.5	-1.2
Intermittent access day 15 total infusions	1.0	2.5	5.2	2.3	-1.6	-1.7	-1.4	-1.5	0.2
Intermittent access terminal intake (last 3 days)	0.8	1.4	3.4	1.8	-1.2	-1.2	-1.0	-1.1	-0.1
Intermittent access total infusions	0.6	0.8	2.3	1.5	-0.8	-0.8	-0.6	-0.7	-0.4
Intermittent access day 1 locomotion	0.5	0.9	2.4	1.6	-0.4	-0.6	-0.4	-0.4	-1.5
Intermittent access day 15 total locomotion	0.7	2.9	4.2	2.1	-1.7	-1.9	-1.7	-1.8	-0.6
Intermittent access total locomotion	1.1	1.3	3.3	1.8	-0.8	-1.0	-0.7	-0.8	-1.3
Intermittent access standard deviation	0.6	3.0	3.6	1.9	-1.9	-1.9	-1.7	-1.8	1.1
Left kidney weight	0.7	6.0	11.2	3.3	-2.5	-2.5	-2.4	-2.4	-0.2
Right kidney weight	0.3	2.0	6.3	2.5	-1.3	-1.3	-1.0	-1.0	0.0
Cocaine induced anxiety	0.9	2.5	3.8	-1.9	1.7	1.5	1.7	1.6	-0.7
Post-drug Anxiety	1.1	1.2	1.9	-1.4	1.1	1.0	1.2	1.2	-0.5
Baseline Anxiety	0.6	1.0	1.5	1.2	-1.2	-1.0	-1.0	-1.0	0.2
Tail length	4.7	25.5	49.5	7.0	-4.8	-5.4	-5.0	-5.0	-1.1
Length with tail	6.3	27.9	53.8	7.3	-5.3	-5.6	-5.2	-5.2	-0.5
Length without tail	1.0	5.4	11.6	3.4	-2.4	-2.4	-2.1	-2.2	-0.0
Times rat made contact with spout	4.3	5.0	5.3	2.2	-2.3	-2.1	-2.3	-2.3	2.3
Lifetime Intake	0.4	0.5	2.0	1.4	-0.7	-0.7	-0.4	-0.5	-0.1
Liver weight, left	3.7	6.4	11.1	3.3	-2.6	-2.8	-2.5	-2.5	0.6
Liver weight, right	2.9	5.0	7.8	2.8	-2.4	-2.4	-2.3	-2.2	0.4
Locomotor activity	0.6	1.0	2.1	1.1	-0.8	-0.8	-0.7	-0.8	1.5
Locomotor testing distance	0.1	0.3	1.6	0.4	-0.0	0.2	0.1	0.0	1.3
Locomotor testing rearing	0.1	0.4	1.5	0.4	-0.4	-0.4	-0.5	-0.7	1.2
Locomotion in novel chamber	0.1	0.1	0.3	0.2	0.1	0.1	0.1	0.1	0.6
Locomotion in novel chamber post-restriction	0.2	0.6	2.0	1.4	-0.4	-0.8	-0.5	-0.5	-0.6
Fecal boli incidents, locomotor time 1	0.1	0.3	0.7	0.7	-0.3	-0.3	-0.3	-0.3	-0.8
Change in fecal boli incidents, locomotor task	2.4	2.5	3.7	-1.8	1.7	1.9	1.6	1.7	-0.5
Time >=10cm from walls, locomotor time 1	1.5	1.9	2.6	-1.6	1.5	1.3	1.6	1.5	-0.1
Bouts of movement, locomotor time 1	0.2	0.3	0.5	-0.6	0.7	0.3	0.6	0.4	0.6
Total resting periods, locomotor time 1	0.2	0.2	0.5	-0.7	0.4	0.2	0.3	0.2	0.6
Rest time, locomotor task time 1	0.2	0.3	1.2	-1.1	0.0	0.3	0.4	0.2	0.3
Distance moved, locomotor task time 1	0.3	0.7	1.3	0.7	-0.8	-0.7	-0.9	-0.7	1.1
Vertical activity count, locomotor time 1	0.1	0.4	1.1	0.8	-0.4	-0.5	-0.6	-0.4	1.0
Time >=10cm from walls, locomotor time 2	0.5	1.4	5.8	-0.7	-0.8	-0.8	-0.7	-0.6	2.4
Bouts of movement, locomotor time 2	0.1	0.3	0.7	-0.3	0.6	0.5	0.5	0.3	-0.9
Total resting periods, locomotor time 2	0.2	0.6	0.9	-0.8	0.9	0.8	0.8	0.6	-0.8
Rest time, locomotor task time 2	1.2	2.0	2.7	-1.6	1.5	1.5	1.4	1.4	-0.9
Distance moved, locomotor task time 2	2.1	2.8	3.5	1.1	-1.8	-1.8	-1.8	-1.7	1.9
Vertical activity count, locomotor time 2	1.8	4.2	8.4	1.6	-1.9	-1.9	-1.9	-1.8	2.9
Light reinforcement 1	0.0	0.2	0.4	0.6	-0.6	-0.2	-0.2	-0.2	0.3
Light reinforcement 2	0.4	0.9	1.8	0.1	0.6	1.0	1.1	1.1	-1.3
Bone: marrow area	1.4	3.4	5.0	-0.5	2.2	2.0	2.1	2.2	-1.3
Bone: maximum diameter	0.1	0.2	0.7	0.9	0.4	0.3	0.3	0.4	-0.2
Bone: maximum force	0.5	1.0	1.6	-0.7	1.2	1.0	1.2	1.2	-0.6
Bone: maximum moment	0.5	0.9	1.4	-0.8	1.2	0.9	1.1	1.1	-0.1
Mean time between licks in bursts	0.1	0.5	0.7	-0.8	0.6	0.8	0.4	0.6	0.9
Mean num. licks in bursts	0.2	0.6	1.0	0.5	-0.8	-0.8	-1.0	-1.0	0.5
Cd content in liver	0.4	0.4	0.6	-0.8	0.8	0.6	0.6	0.6	0.3
Co content in liver	0.0	0.0	0.1	0.3	-0.2	0.1	-0.0	0.0	-0.1
Cu content in liver	0.4	0.5	0.8	0.9	-0.6	-0.4	-0.7	-0.6	-0.9
Fe content in liver	0.9	1.1	1.5	-0.3	1.1	1.0	1.2	1.2	-1.0
K content in liver	3.7	3.6	6.0	1.8	-2.5	-1.9	-2.1	-2.1	0.4
Mg content in liver	0.5	0.6	1.1	0.4	-1.1	-0.6	-1.0	-0.9	0.4
Mn content in liver	0.0	0.0	0.0	0.1	-0.2	0.2	0.0	0.1	0.1
Na content in liver	0.5	0.5	0.9	0.6	-0.9	-0.8	-0.8	-0.8	0.1
Rb content in liver	0.5	0.5	2.3	0.6	-0.0	-0.2	-0.5	-0.5	-1.5
Se content in liver	0.3	0.3	0.6	-0.7	0.4	0.8	0.5	0.6	-0.4
Sr content in liver	1.4	1.2	4.1	-0.3	-0.5	-1.1	-0.9	-1.0	2.0
Zn content in liver	3.5	4.0	5.7	2.2	-2.3	-1.7	-2.4	-2.3	-0.1
Bone: minimum diameter	0.1	0.2	0.8	0.9	0.3	0.1	0.3	0.3	0.2
Time in familiar zone, hab. session 1	0.2	0.3	0.4	-0.6	0.6	0.5	0.5	0.5	-0.4
Time in novel zone, hab. session 1	0.4	0.5	0.7	-0.1	0.7	0.8	0.8	0.8	-0.5
Total zone transitions, hab. session 1	1.0	1.4	6.5	-0.2	-0.8	-0.6	-0.6	-0.6	2.6
Total locomotion distance, hab. session 1	1.3	1.8	5.9	0.1	-1.3	-1.1	-1.0	-1.1	2.4
Locomotion velocity, hab. session 1	2.4	3.4	9.7	0.2	-1.8	-1.5	-1.5	-1.6	3.1
Time in familiar zone, hab. session 2	0.1	0.1	0.3	-0.4	0.3	0.3	0.2	0.2	0.5
Time in novel zone, hab. session 2	0.7	0.7	0.9	-0.7	0.9	0.7	1.0	0.9	-0.9
Total zone transitions, hab. session 2	1.0	1.3	4.5	-1.4	0.4	0.6	0.5	0.5	2.1
Total locomotion distance, hab. session 2	1.0	1.2	6.2	-1.1	-0.0	0.3	0.2	0.1	2.5
Locomotion velocity, hab. session 2	0.9	1.2	5.9	-1.1	-0.1	0.3	0.2	0.1	2.4
Novel to familiar place preference ratio	0.6	0.8	1.3	0.8	-1.1	-1.1	-0.9	-1.0	-0.5
Novelty place preference	0.5	0.6	1.0	0.5	-1.0	-0.9	-0.8	-0.8	-0.4
Time in novel zone, NPP test	0.4	0.4	0.7	0.5	-0.9	-0.8	-0.7	-0.7	-0.4
Total zone transitions, NPP test	0.3	0.4	0.8	-0.9	0.4	0.6	0.6	0.6	0.8
Total locomotion distance, NPP test	0.4	0.5	2.8	-0.3	-0.4	-0.2	-0.2	-0.2	1.7
Locomotion velocity, NPP test	0.3	0.4	2.2	-0.3	-0.4	-0.2	-0.2	-0.2	1.5
Intraocular pressure	0.2	0.4	0.6	-0.5	0.7	0.7	0.7	0.8	-0.1
Delta distance traveled before/after self-admin	0.4	0.4	0.6	-0.8	0.7	0.5	0.7	0.6	-0.5
Delta ambulatory time before/after self-admin	0.8	1.4	2.0	-1.4	1.3	1.1	1.3	1.3	-0.6
Parametrial fat weight	1.3	2.9	4.3	-1.5	1.8	2.1	1.8	1.9	-1.1
Pavlov. Cond. lever latency	1.0	1.3	4.3	0.4	0.9	0.8	0.9	1.0	-2.1
Pavlov. Cond. magazine entry latency	0.4	0.6	2.3	-1.0	0.0	0.1	-0.0	-0.0	1.5
Pavlov. Cond. change in total contacts	0.5	0.5	2.8	-0.3	-0.2	-0.1	-0.4	-0.3	1.7
Pavlov. Cond. index score	0.9	1.1	5.1	-1.1	-0.2	-0.1	-0.2	-0.3	2.3
Pavlov. Cond. latency score	0.9	1.1	5.2	-1.0	-0.4	-0.3	-0.4	-0.5	2.3
Pavlov. Cond. lever contacts	1.1	1.4	4.7	-0.3	-0.9	-0.8	-1.0	-1.0	2.2
Pavlov. Cond. magazine entry number	0.4	0.5	1.5	1.0	-0.3	-0.4	-0.3	-0.3	-1.2
Pavlov. Cond. intertrial magazine entries	1.4	1.6	2.7	-0.5	1.4	1.6	1.4	1.5	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	5.0	-1.2	-0.0	0.0	-0.0	-0.1	2.2
Pavlov. Cond. response bias	0.8	0.9	4.4	-0.8	-0.5	-0.3	-0.4	-0.4	2.1
Pavlov. Cond. lever latency	0.6	0.9	2.1	1.5	-0.6	-0.9	-0.7	-0.8	-0.8
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	0.3	-0.5	-0.3	-0.5	-0.4	-0.2
Pavlov. Cond. change in total contacts	0.0	0.1	0.2	-0.3	0.2	0.4	0.2	0.3	0.2
Pavlov. Cond. index score	0.0	0.0	0.1	-0.2	-0.2	0.1	-0.1	-0.1	0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.0	0.0	0.1
Pavlov. Cond. lever contacts	0.7	1.0	2.1	-1.4	0.7	1.0	0.8	0.8	0.9
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.2	0.3	-0.0	0.2	0.1	0.1
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.2	-0.4	0.1	0.1	0.1	-0.0	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.1	-0.5	-0.2	-0.4	-0.3	0.4
Pavlov. Cond. response bias	0.2	0.3	0.8	-0.9	0.3	0.6	0.3	0.4	0.7
Time in closed arm before self-admin	0.1	0.2	0.3	0.6	-0.5	-0.4	-0.6	-0.5	0.4
Time in closed arm after self-admin	0.4	0.5	2.1	0.5	0.2	0.4	0.4	0.4	-1.5
Time in open arm before self-admin	0.0	0.1	0.1	-0.3	0.2	0.1	0.2	0.2	-0.3
Time in open arm after self-admin	1.2	1.3	2.9	-1.7	1.1	1.1	1.0	1.1	0.9
Bone: periosteal estimation	0.6	1.5	2.3	-0.0	1.5	1.2	1.4	1.5	-1.0
Bone: periosteal perimeter	0.3	0.6	0.9	0.2	0.9	0.8	1.0	0.9	-0.7
Bone: post-yield work	0.1	0.1	0.3	0.0	0.6	0.3	0.3	0.2	-0.6
Progressive ratio test 1 active lever presses	2.0	3.5	7.7	2.8	-1.8	-1.9	-1.7	-1.7	0.7
Progressive ratio test 1 breakpoint	2.2	3.7	7.9	2.8	-1.9	-2.0	-1.7	-1.8	0.7
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.2	0.5	-0.4	-0.3	-0.3	-0.3	-0.1
Progressive ratio test 2 active lever presses	1.7	2.4	2.9	1.7	-1.7	-1.7	-1.5	-1.5	1.3
Progressive ratio test 2 breakpoint	2.1	2.6	3.1	1.7	-1.8	-1.8	-1.5	-1.6	1.3
Progressive ratio test 2 inactive lever presses	0.1	0.4	0.9	0.5	-0.9	-0.7	-0.6	-0.6	0.3
Incentive Sensitization - Responses	0.7	1.9	2.4	1.3	-1.6	-1.4	-1.4	-1.4	1.1
Incentive Sensitization - Breakpoint	0.7	1.6	2.1	1.2	-1.5	-1.3	-1.3	-1.3	1.0
Sum of active levers in priming session hrs 5-6	2.3	2.2	8.0	0.3	-1.2	-1.2	-1.0	-1.0	2.8
Progressive ratio	0.8	2.4	3.3	-1.4	1.6	1.6	1.4	1.3	-1.8
Food seeking constrained by brief footshock	1.5	1.9	3.1	1.8	-1.2	-1.3	-1.6	-1.6	0.0
Seeking ratio, punishment vs. effort	1.0	2.3	2.7	1.6	-1.7	-1.6	-1.6	-1.5	1.1
Retroperitoneal fat weight	0.6	2.5	3.8	1.9	-1.5	-1.4	-1.7	-1.6	1.3
Reaction time number correct	0.1	0.4	1.2	-0.3	0.6	0.0	0.4	0.5	1.1
Reaction time mean minus median	0.0	0.2	0.9	-1.0	0.5	0.3	-0.0	-0.0	0.1
Reaction time mean minus median AUC	0.0	0.3	0.8	-0.7	0.2	-0.2	-0.5	-0.5	0.9
Reaction time num false alarms	0.0	0.0	0.1	-0.4	-0.0	0.0	0.1	0.1	0.0
Reaction time num false alarms AUC	0.1	0.2	0.6	-0.8	0.4	0.4	0.5	0.5	-0.2
Reaction time trials correct on left	0.1	0.4	1.2	-0.3	0.6	0.0	0.4	0.5	1.1
Reaction time trials on left	0.1	0.4	1.2	-0.4	0.7	0.1	0.5	0.5	1.1
Reaction time mean	0.1	0.3	0.6	-0.6	0.8	0.7	0.5	0.4	0.2
Reaction time mean AUC	0.0	0.1	0.3	-0.3	0.5	0.4	0.2	0.1	0.2
Median of all reaction times	0.1	0.2	0.5	-0.2	0.6	0.7	0.4	0.4	0.1
Reaction time omissions	1.3	2.2	3.7	-1.9	1.7	1.6	1.4	1.3	-0.4
Reaction time false alarm rate	0.2	0.2	0.6	-0.6	0.2	0.5	0.4	0.4	-0.8
Reaction time premature initiation rate	0.5	0.8	1.3	-1.0	0.7	0.9	0.8	0.7	1.2
Reaction time premature initiations	0.2	0.7	3.0	-0.6	0.5	0.3	0.4	0.4	1.7
Std. dev. reaction times	0.1	0.5	1.5	-1.2	0.8	0.5	0.3	0.2	0.5
Reaction time trials completed	0.1	0.4	1.2	-0.4	0.7	0.1	0.5	0.5	1.1
Reaction time trials AUC	0.1	0.4	1.2	-0.3	0.7	0.1	0.5	0.5	1.1
Run reversals in cocaine runway, females	0.0	0.0	0.1	0.4	-0.2	-0.2	-0.2	-0.2	0.0
Run reversals in cocaine runway, males	0.3	0.3	1.2	0.0	-0.5	-0.3	-0.5	-0.5	1.1
Latency to leave start box in cocaine runway	0.1	0.2	0.3	0.2	-0.5	-0.5	-0.3	-0.4	0.5
Latency to leave start box in cocaine runway, F	0.4	0.5	1.3	-1.2	0.5	0.7	0.8	0.8	0.0
Latency to leave start box in cocaine runway, M	3.1	2.9	3.7	1.9	-1.7	-1.9	-1.6	-1.9	1.1
Std. dev. time between licks in bursts	1.2	2.3	4.5	-2.1	1.4	1.6	1.4	1.5	0.8
Total sessions with >9 infusions	0.8	1.0	2.6	1.6	-1.0	-0.9	-0.8	-0.8	0.8
Short access day 1 total inactive lever presses	0.2	0.5	2.1	0.2	0.3	0.4	0.5	0.5	-1.4
Short access day 10 total inactive lever presses	0.2	1.7	4.9	-2.2	1.0	1.3	0.9	0.9	-1.0
Short access day 1 total infusions	0.1	0.3	0.5	0.0	0.5	0.5	0.7	0.6	-0.5
Short access day 10 total infusions	0.4	0.6	2.0	1.4	-0.8	-0.7	-0.4	-0.5	-0.5
Short access total infusions	0.1	0.2	0.7	0.9	-0.3	-0.2	0.0	-0.1	-0.0
Short access day 1 locomotion	0.5	0.8	1.0	1.0	-0.9	-0.9	-0.8	-0.9	0.8
Short access day 10 total locomotion	0.1	0.4	0.5	-0.6	0.7	0.6	0.7	0.6	-0.5
Short access total locomotion	1.0	1.6	2.0	1.4	-1.4	-1.3	-1.3	-1.4	0.6
One hour access (0.3 mA shock)	5.1	6.1	8.3	2.9	-2.5	-2.7	-2.3	-2.4	1.8
Compulsive drug intake	0.4	0.7	1.0	0.7	-0.9	-1.0	-0.9	-0.9	0.5
One hour access (shock baseline)	1.2	3.1	4.5	2.1	-1.8	-2.0	-1.7	-1.7	1.0
Social response proportion	0.1	0.1	0.1	0.3	0.4	0.2	0.4	0.3	0.3
Social responses	0.5	0.7	3.8	-0.2	-0.0	-0.1	-0.1	-0.1	2.0
Social time	0.8	1.2	3.1	0.9	-0.7	-1.2	-0.9	-0.9	1.8
Soleus weight	0.4	1.2	1.9	-0.6	1.3	1.2	1.4	1.3	-0.3
Bone: stiffness	0.2	0.4	0.7	0.1	0.8	0.5	0.8	0.7	-0.0
Tibialis anterior weight	0.6	2.0	3.3	-1.1	1.8	1.1	1.8	1.7	-0.3
Time to tail flick, vehicle, before self-admin	4.1	5.0	6.2	2.4	-2.5	-2.3	-2.3	-2.4	1.3
Time to tail flick, vehicle, after self-admin	0.6	1.1	3.3	-1.8	0.9	0.9	0.9	0.9	0.6
Time to tail flick, test, before self-admin	0.4	0.4	0.9	0.4	0.7	0.5	0.6	0.7	-0.9
Time to tail flick, test, after self-admin	0.0	0.1	0.1	0.1	0.2	0.3	0.3	0.2	-0.2
Delta time to tail flick, vehicle, before/after SA	4.4	4.7	8.2	-2.9	2.3	2.3	2.2	2.2	-0.1
Delta time to tail flick, test, before/after SA	0.2	0.2	0.5	-0.5	-0.4	-0.2	-0.4	-0.5	0.7
Tibia length	2.5	7.0	15.5	3.9	-2.7	-2.6	-2.4	-2.5	0.2
Ambulatory time before self-admin	0.0	0.1	0.1	0.4	-0.1	-0.3	-0.3	-0.3	0.0
Ambulatory time after self-admin	0.9	1.4	2.1	-1.2	1.4	1.0	1.3	1.2	-0.8
Bone: tissue strength	0.2	0.3	0.9	-0.4	0.4	0.3	0.4	0.4	0.9
Total heroin consumption	2.6	3.0	4.1	-2.0	1.8	1.8	1.9	1.9	0.9
Bone: trabecular number	0.0	0.1	0.2	0.1	-0.3	-0.4	0.1	0.0	0.4
Bone: trabecular spacing	0.0	0.0	0.1	-0.2	0.2	-0.1	-0.2	-0.3	-0.2
Bone: trabecular thickness	0.3	0.4	0.7	0.6	-0.8	-0.7	-0.6	-0.6	0.6
Bone: trabecular tissue density	0.1	0.2	0.3	0.1	-0.4	-0.3	-0.6	-0.4	0.4
Water consumed over 24 hours	1.7	3.4	6.9	2.6	-1.8	-1.8	-1.8	-1.8	-0.3
Number of responses in last shaping day	0.1	0.1	0.4	-0.0	-0.3	-0.3	-0.3	-0.4	0.6