Hub : Genes

Rpl28

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye gene expression Rpl28 0.35 0.2 3.2e-03 0.04 0 -0.02 0.01 8.0e-02 2.7e-01 7.3e-01 2.1e-01
2 LHb gene expression Rpl28 0.45 0.16 5.8e-09 0.33 0.31 0.32 0.33 1.3e-08 5.1e-08 2.0e-08 1.5e-08
3 Brain gene expression Rpl28 0.46 0.16 0.0e+00 0.44 0.41 0.46 0.47 1.2e-44 1.8e-41 1.9e-47 3.1e-49
4 Liver gene expression Rpl28 0.27 0.11 0.0e+00 0.25 0.25 0.25 0.26 1.5e-27 5.4e-28 1.7e-27 2.3e-28
5 BLA gene expression Rpl28 0.46 0.15 0.0e+00 0.33 0.3 0.32 0.32 3.4e-18 1.8e-16 2.3e-17 9.5e-18
6 RMTg gene expression Rpl28 0.28 0.14 1.0e-07 0.14 0.28 0.26 0.25 1.2e-04 5.5e-08 1.5e-07 2.3e-07
7 IL gene expression Rpl28 0.16 0.12 2.9e-03 0.1 0.07 0.09 0.06 2.2e-03 9.7e-03 3.1e-03 1.3e-02
8 NAcc gene expression Rpl28 0.23 0.09 0.0e+00 0.26 0.26 0.26 0.25 4.0e-39 1.1e-38 1.0e-38 5.8e-38
9 IC gene expression Rpl28 0.7 0.11 0.0e+00 0.46 0.46 0.47 0.47 2.8e-21 2.3e-21 5.4e-22 1.0e-21
10 pVTA gene expression Rpl28 0.68 0.12 0.0e+00 0.29 0.4 0.4 0.39 2.3e-23 4.8e-34 4.3e-34 3.6e-33
11 PL gene expression Rpl28 0.34 0.12 0.0e+00 0.37 0.36 0.37 0.36 3.1e-42 3.7e-41 5.8e-43 3.1e-41
12 Adipose gene expression Rpl28 0.06 0.04 1.2e-04 0.03 0.03 0.02 0.03 3.8e-04 2.2e-04 3.2e-03 3.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.10.20.3-0.5-0.5-0.5-0.5-0.3-0.4-0.2-0.4-0.4-0.4-0.5-0.5
Area under the delay curve0.30.41.00.60.60.60.60.50.61.00.60.60.50.30.6
BMI with tail0.62.02.21.41.41.41.41.41.41.31.41.51.31.31.4
BMI without tail0.00.00.30.00.00.00.00.0-0.2-0.5-0.1-0.00.20.20.1
Body weight0.62.66.4-1.5-1.5-1.5-1.5-1.6-1.9-2.5-1.8-1.6-1.3-0.9-1.2
Weight adjusted by age1.01.51.8-1.3-1.3-1.3-1.3-1.2-1.1-0.5-1.3-1.3-1.3-1.3-1.2
Bone surface2.44.46.6-2.2-2.2-2.2-2.2-2.1-2.2-2.6-2.1-2.1-1.8-1.5-1.8
Bone volume2.13.74.5-2.1-2.1-2.1-2.1-1.9-2.0-2.1-1.9-1.9-1.5-1.5-1.8
Breakpoint value in progressive ratio session0.30.40.90.60.60.60.60.60.7-0.10.60.60.51.00.6
Number of licking bursts0.10.10.30.50.50.50.50.20.30.10.20.30.30.30.3
Context. condit. distance diff. score0.00.00.20.00.00.00.00.10.1-0.0-0.0-0.0-0.40.20.0
Locomotion velocity, session 11.31.42.7-1.2-1.2-1.2-1.2-1.0-0.70.9-1.0-1.0-1.6-1.6-1.4
Locomotion distance, session 13.94.96.1-2.3-2.3-2.3-2.3-2.2-2.1-1.5-2.2-2.2-2.5-2.1-2.3
Locomotion velocity, session 20.20.20.5-0.3-0.3-0.3-0.3-0.4-0.10.6-0.3-0.3-0.5-0.7-0.6
Locomotion distance, session 22.53.64.6-2.0-2.0-2.0-2.0-1.8-1.8-0.9-1.9-1.9-1.9-2.1-2.0
Locomotion velocity, session 30.00.00.00.00.00.00.00.00.10.1-0.0-0.0-0.1-0.0-0.1
Locomotion distance, session 30.50.50.8-0.8-0.8-0.8-0.8-0.8-0.6-0.5-0.7-0.7-0.9-0.7-0.8
Stereotopy head waving bouts, day 30.20.20.70.50.50.50.50.40.4-0.30.50.50.40.80.5
Stereotopy head waving duration, day 30.20.30.60.50.50.50.50.50.4-0.20.50.50.50.80.5
Locomotion velocity, session 70.20.30.4-0.6-0.6-0.6-0.6-0.4-0.4-0.4-0.5-0.5-0.6-0.4-0.6
Locomotion distance, session 70.30.30.6-0.6-0.6-0.6-0.6-0.4-0.40.3-0.5-0.5-0.8-0.8-0.7
Stereotopy head waving bouts, day 70.10.21.5-0.1-0.1-0.1-0.1-0.2-0.2-1.2-0.1-0.10.00.5-0.0
Stereotopy head waving duration, day 70.10.11.1-0.1-0.1-0.1-0.1-0.2-0.2-1.1-0.1-0.10.00.4-0.0
Locomotion velocity, session 80.20.30.7-0.6-0.6-0.6-0.6-0.4-0.3-0.2-0.5-0.5-0.8-0.4-0.7
Locomotion distance, session 80.50.81.7-0.9-0.9-0.9-0.9-0.7-0.7-0.3-0.9-0.9-1.3-0.8-0.9
Degree of sensitization distance0.00.00.0-0.1-0.1-0.1-0.1-0.0-0.1-0.1-0.1-0.1-0.2-0.1-0.1
Degree of sensitization stereotypy0.10.10.50.20.20.20.20.10.0-0.70.10.10.30.60.2
Conditioned locomotion0.20.20.6-0.5-0.5-0.5-0.5-0.5-0.4-0.5-0.5-0.5-0.7-0.2-0.5
Cocaine response after cond. corrected2.73.24.71.71.71.71.71.91.71.51.91.92.21.51.9
Cocaine response after cond. not corrected0.10.10.50.20.20.20.20.30.10.20.30.30.70.10.4
Cocaine response before conditioning7.48.99.8-3.0-3.0-3.0-3.0-3.1-3.1-2.8-3.1-3.1-3.0-2.7-2.9
Saline control response0.40.51.0-0.6-0.6-0.6-0.6-0.8-0.5-0.6-0.7-0.7-1.0-0.5-0.9
Bone: connectivity density0.00.00.10.20.20.20.20.20.20.30.20.20.20.10.2
Bone: cortical apparent density0.50.72.3-0.8-0.8-0.8-0.8-0.5-0.51.1-0.6-0.7-0.7-1.5-0.8
Bone: cortical area0.71.12.4-1.0-1.0-1.0-1.0-1.1-1.1-1.6-1.0-1.0-1.0-0.5-0.8
Bone: cortical porosity0.90.92.20.90.90.90.90.90.9-0.41.01.01.11.50.9
Bone: cortical porosity0.60.72.20.70.70.70.70.70.6-1.00.70.71.01.50.7
Bone: cortical thickness0.10.20.30.50.50.50.50.40.60.40.50.50.30.50.3
Bone: cortical thickness0.30.31.1-0.5-0.5-0.5-0.5-0.5-0.50.4-0.6-0.6-0.6-1.0-0.6
Bone: cortical tissue density0.50.62.2-0.7-0.7-0.7-0.7-0.4-0.41.1-0.6-0.6-0.7-1.5-0.7
Condit. Reinf. active minus inactive responses0.20.30.60.50.50.50.50.50.5-0.10.50.50.50.80.5
Condit. Reinf. active-inactive response ratio1.82.02.31.51.51.51.51.41.51.01.41.41.21.51.5
Condit. Reinf. active responses0.10.21.0-0.4-0.4-0.4-0.4-0.3-0.3-1.0-0.3-0.3-0.20.2-0.3
Condit. Reinf. inactive responses3.54.35.1-2.2-2.2-2.2-2.2-2.0-2.1-2.3-2.1-2.1-1.9-1.6-2.1
Incentive salience index mean0.10.10.2-0.3-0.3-0.3-0.3-0.2-0.3-0.4-0.2-0.3-0.3-0.1-0.2
Condit. Reinf. lever presses0.81.21.7-1.2-1.2-1.2-1.2-1.0-1.1-0.4-1.0-1.1-1.0-1.3-1.0
Condit. Reinf. active minus inactive responses3.34.36.5-2.0-2.0-2.0-2.0-2.3-2.3-2.6-2.2-2.2-1.9-1.5-2.0
Condit. Reinf. active-inactive response ratio4.04.76.8-2.2-2.2-2.2-2.2-2.3-2.4-2.6-2.2-2.2-1.7-1.7-2.0
Condit. Reinf. active responses3.24.57.0-1.9-1.9-1.9-1.9-2.4-2.2-2.7-2.2-2.2-2.2-1.4-2.1
Condit. Reinf. inactive responses0.10.20.9-0.1-0.1-0.1-0.1-0.5-0.2-0.9-0.4-0.3-0.70.3-0.3
Condit. Reinf. lever presses0.30.43.4-0.1-0.1-0.1-0.1-0.3-0.5-1.8-0.3-0.3-0.00.60.0
Condit. Reinf. lever reinforcers received4.15.78.6-2.2-2.2-2.2-2.2-2.6-2.5-2.9-2.5-2.5-2.5-1.7-2.3
Conditioned reinforcement - actives0.20.30.7-0.8-0.8-0.8-0.8-0.2-0.40.6-0.1-0.2-0.1-0.9-0.1
Conditioned reinforcement - inactives2.84.06.2-2.3-2.3-2.3-2.3-1.8-1.9-0.5-1.8-1.9-1.7-2.5-1.8
Conditioned locomotion0.10.10.2-0.5-0.5-0.5-0.5-0.1-0.20.1-0.0-0.00.0-0.3-0.0
Patch foraging indifference point 0 sec0.00.10.7-0.0-0.0-0.0-0.00.10.40.80.30.3-0.20.10.1
Patch foraging indifference point AUC0.60.81.20.90.90.90.91.10.90.90.90.90.80.60.8
Delay disc. indifference point, 0s delay0.40.41.0-0.6-0.6-0.6-0.6-0.6-0.40.5-0.6-0.7-1.0-1.0-0.7
Delay disc. indifference point, 16s delay1.92.13.21.51.51.51.51.41.20.31.51.61.71.81.5
Delay disc. indifference point, 2s delay0.50.53.80.50.50.50.50.30.61.90.40.50.3-0.50.3
Delay disc. indifference point, 24s delay1.11.21.61.11.11.11.11.11.00.51.21.21.21.31.1
Delay disc. indifference point, 4s delay0.00.00.1-0.0-0.0-0.0-0.0-0.2-0.20.3-0.1-0.10.0-0.4-0.0
Delay disc. indifference point, 8s delay0.00.10.40.20.20.20.20.10.20.60.20.20.0-0.00.2
Indifference point function ln k5.08.710.7-3.0-3.0-3.0-3.0-3.3-3.0-2.7-3.0-3.0-2.8-2.6-3.0
Indifference point function log k5.08.710.7-3.0-3.0-3.0-3.0-3.3-3.0-2.7-3.0-3.0-2.8-2.6-3.0
Patch foraging total patch changes 0 sec0.00.10.60.10.10.10.10.10.40.80.30.2-0.20.10.1
Patch foraging total patch changes 12 sec0.20.30.60.40.40.40.40.80.60.50.70.60.40.70.7
Patch foraging total patch changes 18 sec0.30.51.00.70.70.70.70.70.81.00.70.70.40.60.7
Patch foraging total patch changes 24 sec0.10.20.30.40.40.40.40.50.2-0.20.40.40.50.50.5
Patch foraging total patch changes 6 sec0.71.01.40.90.90.90.91.21.11.11.11.10.81.01.0
Patch foraging time to switch 0 sec4.38.711.53.03.03.03.03.12.71.53.13.13.43.03.3
Patch foraging water rate 0 sec1.02.23.2-1.5-1.5-1.5-1.5-1.6-1.3-0.8-1.5-1.5-1.8-1.4-1.6
Patch foraging water rate 12 sec2.65.57.6-2.2-2.2-2.2-2.2-2.7-2.2-1.5-2.6-2.5-2.8-2.3-2.5
Patch foraging water rate 18 sec1.52.43.3-1.4-1.4-1.4-1.4-1.6-1.5-1.0-1.6-1.6-1.8-1.6-1.7
Patch foraging water rate 24 sec1.31.92.4-1.3-1.3-1.3-1.3-1.6-1.3-0.9-1.4-1.4-1.5-1.3-1.4
Patch foraging water rate 6 sec4.66.68.5-2.4-2.4-2.4-2.4-2.9-2.8-2.9-2.7-2.7-2.3-2.2-2.5
Seeking ratio, delayed vs. immediate footshock0.70.91.8-1.0-1.0-1.0-1.0-0.9-0.6-0.4-0.9-0.9-1.3-0.7-0.9
Distance traveled before self-admin4.55.98.0-2.5-2.5-2.5-2.5-2.6-2.1-1.1-2.5-2.5-2.8-2.5-2.5
Distance traveled after self-admin0.10.20.7-0.3-0.3-0.3-0.3-0.40.0-0.5-0.4-0.4-0.90.2-0.5
Extensor digitorum longus weight0.10.31.3-0.5-0.5-0.5-0.5-0.5-0.7-1.1-0.5-0.5-0.2-0.1-0.3
Bone: elastic displacement0.10.10.50.20.20.20.20.60.4-0.20.30.30.00.70.1
Bone: elastic work0.70.91.2-1.0-1.0-1.0-1.0-0.9-0.9-0.5-1.0-1.0-1.1-1.0-1.0
Bone: endosteal estimation2.04.35.5-2.1-2.1-2.1-2.1-2.2-2.3-2.3-2.1-2.1-1.8-1.7-1.7
Bone: endosteal perimeter1.42.94.5-1.7-1.7-1.7-1.7-1.9-1.9-2.1-1.7-1.7-1.7-1.2-1.4
Epididymis fat weight0.20.71.50.70.70.70.70.90.6-0.30.70.81.21.21.1
Delta time in closed arm before/after self-admin0.10.11.00.00.00.00.00.20.21.00.30.20.2-0.30.1
Delta time in open arm before/after self-admin2.32.34.3-1.5-1.5-1.5-1.5-1.5-1.4-2.1-1.6-1.6-1.5-0.8-1.4
Diff in mean of infusions in LGA sessions0.40.41.0-0.6-0.6-0.6-0.6-0.8-0.40.6-0.6-0.6-0.8-1.0-0.7
Delay discount exponential model param0.20.30.8-0.5-0.5-0.5-0.5-0.4-0.5-0.9-0.5-0.5-0.4-0.2-0.5
Extinction: sum of active levers before priming0.00.00.10.00.00.00.00.10.1-0.3-0.2-0.1-0.30.2-0.1
Active lever presses in extinction session 61.01.01.70.90.90.90.91.00.7-0.31.01.01.31.31.1
Bone: final force2.03.24.1-1.9-1.9-1.9-1.9-1.8-1.9-1.0-1.8-1.8-1.5-2.0-1.6
Bone: final moment2.74.35.6-2.2-2.2-2.2-2.2-2.2-2.2-1.1-2.1-2.1-1.8-2.4-1.9
Food consumed during 24 hour testing period1.62.22.4-1.5-1.5-1.5-1.5-1.5-1.6-1.3-1.5-1.5-1.4-1.4-1.3
Glucose1.01.53.01.31.31.31.31.21.41.71.11.10.70.81.0
Heart weight0.71.12.6-1.1-1.1-1.1-1.1-0.9-1.2-1.6-1.0-1.0-0.6-0.6-0.8
Delay discount hyperbolic model param0.30.31.2-0.6-0.6-0.6-0.6-0.4-0.6-1.1-0.5-0.6-0.4-0.2-0.5
Intermittent access intake day 1-15 change0.40.81.0-0.9-0.9-0.9-0.9-0.9-1.0-0.8-1.0-0.9-0.8-1.0-0.8
Intermittent access intake escalation0.51.01.4-0.9-0.9-0.9-0.9-1.0-1.2-1.1-1.1-1.1-0.8-1.1-0.9
Intermittent access intake escalation 20.40.50.6-0.6-0.6-0.6-0.6-0.7-0.6-0.4-0.8-0.8-0.8-0.8-0.8
Intermitt. access day 1 inactive lever presses0.31.11.6-1.2-1.2-1.2-1.2-0.9-1.2-1.3-1.0-1.0-0.7-0.9-0.9
Intermitt. access day 15 inactive lever presses1.02.13.7-1.7-1.7-1.7-1.7-1.2-1.6-1.9-1.3-1.3-0.7-1.0-1.3
Intermitt. access escalation Index0.20.40.70.50.50.50.50.70.70.80.60.60.30.50.7
Intermittent access day 1 total infusions0.30.40.8-0.9-0.9-0.9-0.9-0.5-0.6-0.1-0.4-0.5-0.4-0.8-0.4
Intermittent access day 15 total infusions0.50.71.1-1.0-1.0-1.0-1.0-0.7-0.9-0.4-0.7-0.7-0.5-1.0-0.6
Intermittent access terminal intake (last 3 days)0.60.81.5-1.0-1.0-1.0-1.0-0.8-0.9-0.1-0.8-0.8-0.6-1.2-0.6
Intermittent access total infusions1.21.42.3-1.5-1.5-1.5-1.5-0.9-1.2-0.2-1.0-1.0-0.8-1.5-0.9
Intermittent access day 1 locomotion1.11.42.3-1.4-1.4-1.4-1.4-1.0-1.1-0.1-1.0-1.0-0.9-1.5-0.9
Intermittent access day 15 total locomotion1.42.54.9-1.5-1.5-1.5-1.5-1.7-1.6-0.2-1.7-1.7-1.7-2.2-1.5
Intermittent access total locomotion3.03.65.5-2.0-2.0-2.0-2.0-1.9-2.0-0.7-1.9-1.9-1.8-2.3-1.6
Intermittent access standard deviation0.10.20.60.50.50.50.50.30.40.80.30.30.2-0.00.3
Left kidney weight4.119.228.4-4.4-4.4-4.4-4.4-4.5-4.8-5.3-4.6-4.4-3.9-3.3-3.8
Right kidney weight3.717.030.1-4.3-4.3-4.3-4.3-4.1-4.5-5.5-4.0-4.1-3.4-2.8-3.5
Cocaine induced anxiety0.81.23.6-1.1-1.1-1.1-1.1-1.0-1.1-1.9-1.0-1.0-0.9-0.3-1.0
Post-drug Anxiety0.30.43.3-0.2-0.2-0.2-0.2-0.3-0.5-1.8-0.3-0.30.00.5-0.2
Baseline Anxiety0.81.01.21.11.11.11.11.00.91.01.01.00.90.70.9
Tail length2.59.614.4-3.1-3.1-3.1-3.1-3.2-3.4-3.8-3.2-3.2-2.6-2.4-2.8
Length with tail1.88.015.6-2.7-2.7-2.7-2.7-3.0-3.3-3.9-3.0-2.9-2.3-2.0-2.3
Length without tail0.51.55.8-1.1-1.1-1.1-1.1-1.2-1.5-2.4-1.2-1.1-0.6-0.4-0.6
Times rat made contact with spout0.20.20.30.40.40.40.40.50.40.10.50.50.50.50.5
Lifetime Intake0.81.02.0-1.3-1.3-1.3-1.3-0.7-1.00.1-0.8-0.8-0.6-1.4-0.7
Liver weight, left0.71.12.0-1.0-1.0-1.0-1.0-1.1-1.2-1.4-1.1-1.1-0.9-0.7-0.9
Liver weight, right0.00.00.1-0.2-0.2-0.2-0.2-0.0-0.0-0.20.10.0-0.20.20.1
Locomotor activity0.20.30.40.60.60.60.60.50.50.30.50.50.50.60.6
Locomotor testing distance0.10.20.30.40.40.40.40.30.2-0.20.40.40.60.60.5
Locomotor testing rearing0.20.31.1-0.6-0.6-0.6-0.6-0.5-0.7-1.0-0.6-0.6-0.5-0.1-0.3
Locomotion in novel chamber0.81.12.01.11.11.11.11.01.21.41.11.00.60.71.0
Locomotion in novel chamber post-restriction0.61.02.50.90.90.90.91.01.01.61.11.00.90.41.0
Fecal boli incidents, locomotor time 10.30.40.8-0.6-0.6-0.6-0.6-0.7-0.7-0.1-0.7-0.7-0.8-0.9-0.6
Change in fecal boli incidents, locomotor task2.12.04.91.41.41.41.41.51.62.21.41.41.10.81.2
Time >=10cm from walls, locomotor time 10.10.10.20.20.20.20.20.40.20.20.30.30.30.20.3
Bouts of movement, locomotor time 11.72.03.6-1.4-1.4-1.4-1.4-1.3-1.1-0.3-1.5-1.5-1.9-1.5-1.4
Total resting periods, locomotor time 10.50.51.3-0.6-0.6-0.6-0.6-0.6-0.40.2-0.8-0.8-1.1-0.9-0.7
Rest time, locomotor task time 10.91.11.7-1.0-1.0-1.0-1.0-1.0-1.2-0.6-1.2-1.2-1.0-1.3-1.0
Distance moved, locomotor task time 10.91.32.11.21.21.21.21.11.30.51.21.21.01.51.0
Vertical activity count, locomotor time 10.51.22.11.21.21.21.20.91.41.51.11.10.61.00.8
Time >=10cm from walls, locomotor time 20.71.11.51.01.01.01.01.21.00.91.11.11.10.91.0
Bouts of movement, locomotor time 20.00.00.0-0.1-0.1-0.1-0.1-0.0-0.1-0.0-0.1-0.1-0.2-0.1-0.0
Total resting periods, locomotor time 20.00.10.2-0.2-0.2-0.2-0.2-0.2-0.20.2-0.2-0.2-0.3-0.4-0.2
Rest time, locomotor task time 20.20.30.5-0.5-0.5-0.5-0.5-0.5-0.30.3-0.5-0.5-0.7-0.7-0.5
Distance moved, locomotor task time 20.20.20.40.40.40.40.40.40.4-0.10.40.40.40.70.4
Vertical activity count, locomotor time 20.10.10.20.40.40.40.40.10.40.40.30.30.00.20.3
Light reinforcement 10.20.60.9-0.9-0.9-0.9-0.9-0.5-0.30.5-0.6-0.6-0.9-0.9-0.9
Light reinforcement 20.61.02.81.01.01.01.01.01.11.70.90.90.70.40.7
Bone: marrow area2.04.35.4-2.1-2.1-2.1-2.1-2.2-2.3-2.3-2.1-2.1-1.8-1.7-1.7
Bone: maximum diameter0.51.03.2-0.9-0.9-0.9-0.9-1.1-1.1-1.8-0.9-0.9-0.8-0.3-0.6
Bone: maximum force2.44.25.1-2.2-2.2-2.2-2.2-2.1-2.3-1.8-2.1-2.1-1.8-2.0-1.8
Bone: maximum moment3.05.36.2-2.4-2.4-2.4-2.4-2.4-2.5-1.9-2.3-2.3-2.1-2.3-2.0
Mean time between licks in bursts0.10.21.10.10.10.10.10.40.51.00.40.40.10.00.1
Mean num. licks in bursts0.00.10.2-0.4-0.4-0.4-0.4-0.1-0.2-0.1-0.1-0.1-0.1-0.10.0
Cd content in liver2.32.52.9-1.6-1.6-1.6-1.6-1.7-1.6-1.5-1.6-1.6-1.5-1.4-1.5
Co content in liver2.02.34.9-1.5-1.5-1.5-1.5-1.5-1.30.2-1.5-1.5-1.4-2.2-1.7
Cu content in liver0.60.81.0-0.9-0.9-0.9-0.9-1.0-1.0-0.8-0.9-0.9-0.5-1.0-0.9
Fe content in liver0.20.30.3-0.5-0.5-0.5-0.5-0.6-0.6-0.5-0.5-0.5-0.3-0.5-0.5
K content in liver0.00.00.10.00.00.00.00.10.0-0.40.00.00.10.20.0
Mg content in liver0.40.40.70.60.60.60.60.60.5-0.10.60.60.80.80.7
Mn content in liver0.30.31.20.40.40.40.40.50.3-1.00.40.40.61.10.5
Na content in liver2.42.63.31.71.71.71.71.71.81.01.71.71.51.81.5
Rb content in liver1.51.85.4-1.3-1.3-1.3-1.3-1.3-1.5-2.3-1.3-1.3-0.7-0.6-1.1
Se content in liver2.93.55.41.91.91.91.91.91.80.71.91.91.72.32.0
Sr content in liver2.32.07.31.31.31.31.31.31.82.71.31.30.80.51.0
Zn content in liver1.31.42.21.21.21.21.21.21.00.71.21.21.51.11.3
Bone: minimum diameter2.95.37.9-2.4-2.4-2.4-2.4-2.4-2.4-2.8-2.3-2.3-2.2-1.6-2.0
Time in familiar zone, hab. session 15.14.97.1-2.2-2.2-2.2-2.2-2.3-2.2-0.7-2.3-2.3-2.6-2.7-2.2
Time in novel zone, hab. session 13.03.04.31.81.81.81.81.71.80.71.81.81.92.11.6
Total zone transitions, hab. session 12.12.94.0-1.8-1.8-1.8-1.8-1.7-1.4-0.3-1.7-1.7-1.9-2.0-2.0
Total locomotion distance, hab. session 10.91.32.0-1.2-1.2-1.2-1.2-1.1-0.90.1-1.1-1.1-1.4-1.4-1.4
Locomotion velocity, hab. session 10.70.91.5-1.0-1.0-1.0-1.0-0.9-0.70.1-0.9-0.9-1.1-1.2-1.2
Time in familiar zone, hab. session 21.21.32.2-1.0-1.0-1.0-1.0-1.2-1.4-1.5-1.2-1.2-0.8-1.0-0.8
Time in novel zone, hab. session 21.11.11.61.01.01.01.01.21.31.01.11.11.01.10.8
Total zone transitions, hab. session 23.34.25.0-2.2-2.2-2.2-2.2-2.1-1.9-1.8-2.0-2.0-2.2-1.6-2.0
Total locomotion distance, hab. session 20.40.51.1-0.8-0.8-0.8-0.8-0.6-0.50.0-0.6-0.6-1.0-0.7-0.8
Locomotion velocity, hab. session 20.30.51.0-0.8-0.8-0.8-0.8-0.6-0.40.1-0.6-0.6-1.0-0.7-0.8
Novel to familiar place preference ratio0.00.00.20.00.00.00.0-0.0-0.0-0.40.00.00.10.30.1
Novelty place preference0.10.10.4-0.2-0.2-0.2-0.2-0.3-0.3-0.6-0.2-0.2-0.20.0-0.2
Time in novel zone, NPP test0.10.10.4-0.3-0.3-0.3-0.3-0.3-0.3-0.6-0.3-0.3-0.20.0-0.1
Total zone transitions, NPP test0.60.91.5-0.9-0.9-0.9-0.9-1.0-0.8-0.2-0.9-1.0-1.2-1.1-1.0
Total locomotion distance, NPP test0.30.40.5-0.7-0.7-0.7-0.7-0.6-0.7-0.7-0.7-0.7-0.7-0.5-0.6
Locomotion velocity, NPP test0.50.70.9-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.9-0.6-0.8
Intraocular pressure0.00.00.10.10.10.10.1-0.00.10.30.00.00.1-0.2-0.1
Delta distance traveled before/after self-admin2.52.63.81.71.71.71.71.61.70.71.71.71.51.91.6
Delta ambulatory time before/after self-admin1.31.72.01.31.31.31.31.31.40.91.41.31.11.41.2
Parametrial fat weight1.84.34.92.22.22.22.22.22.11.92.02.11.81.92.1
Pavlov. Cond. lever latency0.00.00.10.30.30.30.30.20.20.20.20.20.20.20.1
Pavlov. Cond. magazine entry latency0.91.21.51.01.01.01.01.21.10.91.21.21.21.01.1
Pavlov. Cond. change in total contacts0.20.20.60.40.40.40.40.40.50.70.50.50.30.30.4
Pavlov. Cond. index score0.30.30.60.50.50.50.50.60.60.80.60.60.50.40.6
Pavlov. Cond. latency score0.20.30.50.40.40.40.40.50.50.70.60.60.50.40.6
Pavlov. Cond. lever contacts0.00.00.1-0.1-0.1-0.1-0.1-0.1-0.1-0.40.00.00.00.20.2
Pavlov. Cond. magazine entry number0.30.40.5-0.6-0.6-0.6-0.6-0.7-0.6-0.6-0.7-0.7-0.7-0.6-0.7
Pavlov. Cond. intertrial magazine entries0.30.41.1-0.5-0.5-0.5-0.5-0.7-0.4-0.2-0.6-0.6-1.1-0.5-0.8
Pavlov. Cond. lever-magazine prob. diff.0.30.40.50.60.60.60.60.60.60.70.70.70.60.50.6
Pavlov. Cond. response bias0.20.20.40.40.40.40.40.40.30.20.50.50.60.40.6
Pavlov. Cond. lever latency0.40.51.0-0.9-0.9-0.9-0.9-0.6-0.60.2-0.6-0.6-0.7-1.0-0.5
Pavlov. Cond. magazine entry latency1.11.41.71.31.31.31.31.21.10.41.11.11.11.31.1
Pavlov. Cond. change in total contacts0.20.31.3-0.3-0.3-0.3-0.3-0.5-0.5-1.2-0.5-0.5-0.40.0-0.6
Pavlov. Cond. index score0.20.20.60.50.50.50.50.40.3-0.50.30.30.60.70.3
Pavlov. Cond. latency score0.60.71.31.01.01.01.00.80.8-0.10.70.80.91.10.7
Pavlov. Cond. lever contacts0.20.30.60.60.60.60.60.40.3-0.50.30.40.50.80.3
Pavlov. Cond. magazine entry number0.60.71.0-1.0-1.0-1.0-1.0-0.9-0.8-0.5-0.8-0.8-0.9-0.8-0.7
Pavlov. Cond. intertrial magazine entries2.84.24.7-2.1-2.1-2.1-2.1-2.1-2.2-2.1-2.1-2.1-1.8-1.7-1.9
Pavlov. Cond. lever-magazine prob. diff.0.20.30.50.60.60.60.60.50.4-0.30.40.40.60.70.3
Pavlov. Cond. response bias0.10.11.0-0.0-0.0-0.0-0.0-0.2-0.3-1.0-0.2-0.20.00.2-0.2
Time in closed arm before self-admin0.60.81.6-0.8-0.8-0.8-0.8-1.0-1.0-1.2-0.9-0.9-0.7-0.6-0.8
Time in closed arm after self-admin0.00.00.20.10.10.10.10.00.00.10.20.20.5-0.00.1
Time in open arm before self-admin1.92.14.21.31.31.31.31.61.52.11.51.51.31.01.3
Time in open arm after self-admin0.00.00.10.00.00.00.00.10.2-0.1-0.0-0.0-0.30.2-0.0
Bone: periosteal estimation1.73.55.1-1.9-1.9-1.9-1.9-2.0-2.1-2.3-1.9-1.9-1.7-1.3-1.5
Bone: periosteal perimeter1.52.64.1-1.6-1.6-1.6-1.6-1.8-1.8-2.0-1.6-1.6-1.5-1.1-1.4
Bone: post-yield work1.62.45.5-1.5-1.5-1.5-1.5-1.6-1.8-2.4-1.5-1.5-1.0-1.0-1.1
Progressive ratio test 1 active lever presses1.82.23.5-1.9-1.9-1.9-1.9-1.2-1.2-0.0-1.2-1.2-1.4-1.7-1.3
Progressive ratio test 1 breakpoint1.72.13.4-1.8-1.8-1.8-1.8-1.2-1.20.0-1.2-1.2-1.3-1.7-1.3
Progressive ratio test 1 inactive lever presses3.04.46.1-2.5-2.5-2.5-2.5-1.9-2.0-0.8-1.9-1.9-1.7-2.4-1.9
Progressive ratio test 2 active lever presses0.30.30.6-0.8-0.8-0.8-0.8-0.3-0.6-0.2-0.3-0.3-0.1-0.7-0.3
Progressive ratio test 2 breakpoint0.30.30.7-0.8-0.8-0.8-0.8-0.4-0.6-0.3-0.4-0.4-0.2-0.7-0.3
Progressive ratio test 2 inactive lever presses2.64.25.3-2.3-2.3-2.3-2.3-2.0-2.1-1.3-1.9-2.0-1.7-2.2-1.9
Incentive Sensitization - Responses0.40.52.0-0.7-0.7-0.7-0.7-0.7-1.0-1.4-0.6-0.6-0.2-0.4-0.4
Incentive Sensitization - Breakpoint0.20.31.5-0.4-0.4-0.4-0.4-0.4-0.7-1.2-0.4-0.30.0-0.1-0.2
Sum of active levers in priming session hrs 5-60.10.10.4-0.1-0.1-0.1-0.1-0.2-0.1-0.6-0.3-0.3-0.50.1-0.3
Progressive ratio0.10.20.3-0.4-0.4-0.4-0.4-0.3-0.2-0.6-0.5-0.4-0.5-0.0-0.5
Food seeking constrained by brief footshock3.54.38.0-2.2-2.2-2.2-2.2-2.0-1.30.2-2.1-2.1-2.8-2.2-2.3
Seeking ratio, punishment vs. effort0.91.32.1-1.2-1.2-1.2-1.2-1.2-1.0-0.2-1.1-1.2-1.3-1.4-1.2
Retroperitoneal fat weight5.121.624.84.84.84.84.85.04.73.94.64.84.54.34.8
Reaction time number correct0.00.00.20.20.20.20.20.10.30.40.20.2-0.00.20.2
Reaction time mean minus median0.00.00.00.10.10.10.10.0-0.00.0-0.1-0.1-0.0-0.1-0.0
Reaction time mean minus median AUC0.00.00.10.20.20.20.20.20.10.10.20.20.20.20.2
Reaction time num false alarms0.00.00.1-0.1-0.1-0.1-0.1-0.3-0.00.20.00.00.1-0.1-0.1
Reaction time num false alarms AUC0.00.10.5-0.0-0.0-0.0-0.0-0.20.20.70.10.10.0-0.3-0.2
Reaction time trials correct on left0.00.00.20.20.20.20.20.10.30.40.20.2-0.00.20.2
Reaction time trials on left0.00.00.20.10.10.10.10.10.30.40.20.2-0.00.20.2
Reaction time mean0.20.30.8-0.5-0.5-0.5-0.5-0.6-0.7-0.9-0.6-0.6-0.1-0.5-0.5
Reaction time mean AUC0.00.00.3-0.0-0.0-0.0-0.0-0.1-0.3-0.5-0.1-0.10.3-0.1-0.1
Median of all reaction times0.20.20.8-0.4-0.4-0.4-0.4-0.5-0.7-0.9-0.5-0.50.1-0.4-0.5
Reaction time omissions0.10.10.4-0.3-0.3-0.3-0.3-0.3-0.10.5-0.3-0.3-0.3-0.6-0.5
Reaction time false alarm rate0.00.00.2-0.1-0.1-0.1-0.1-0.3-0.00.4-0.1-0.1-0.0-0.4-0.3
Reaction time premature initiation rate0.00.00.00.20.20.20.20.10.0-0.20.00.00.10.20.2
Reaction time premature initiations0.10.10.20.40.40.40.40.40.30.10.30.30.30.40.5
Std. dev. reaction times0.10.20.6-0.4-0.4-0.4-0.4-0.4-0.6-0.8-0.5-0.5-0.2-0.4-0.4
Reaction time trials completed0.00.00.20.10.10.10.10.10.30.40.20.2-0.00.20.2
Reaction time trials AUC0.00.10.10.20.20.20.20.20.30.30.20.30.10.30.3
Run reversals in cocaine runway, females0.10.10.5-0.3-0.3-0.3-0.3-0.1-0.3-0.7-0.1-0.10.20.0-0.1
Run reversals in cocaine runway, males0.00.00.2-0.0-0.0-0.0-0.00.0-0.00.50.00.00.1-0.4-0.0
Latency to leave start box in cocaine runway0.40.40.7-0.5-0.5-0.5-0.5-0.7-0.8-0.5-0.8-0.7-0.5-0.8-0.7
Latency to leave start box in cocaine runway, F0.10.10.3-0.1-0.1-0.1-0.1-0.2-0.30.0-0.3-0.3-0.2-0.5-0.3
Latency to leave start box in cocaine runway, M1.00.91.3-0.8-0.8-0.8-0.8-1.1-1.1-1.1-1.1-1.0-0.8-1.0-0.9
Std. dev. time between licks in bursts0.30.50.9-0.8-0.8-0.8-0.8-0.5-0.30.3-0.5-0.5-0.9-0.7-1.0
Total sessions with >9 infusions1.61.93.0-1.7-1.7-1.7-1.7-1.2-1.2-0.2-1.2-1.2-1.2-1.6-1.2
Short access day 1 total inactive lever presses0.20.20.4-0.5-0.5-0.5-0.5-0.5-0.6-0.5-0.3-0.4-0.1-0.5-0.3
Short access day 10 total inactive lever presses0.00.10.20.10.10.10.1-0.4-0.4-0.1-0.4-0.3-0.2-0.5-0.2
Short access day 1 total infusions0.10.10.6-0.3-0.3-0.3-0.3-0.1-0.10.8-0.1-0.1-0.1-0.7-0.2
Short access day 10 total infusions0.10.10.8-0.3-0.3-0.3-0.30.00.00.9-0.0-0.0-0.1-0.6-0.0
Short access total infusions0.20.21.8-0.3-0.3-0.3-0.30.20.11.30.20.20.1-0.60.1
Short access day 1 locomotion0.30.40.8-0.8-0.8-0.8-0.8-0.4-0.50.3-0.3-0.4-0.3-0.9-0.3
Short access day 10 total locomotion1.22.23.9-1.4-1.4-1.4-1.4-1.6-1.3-0.1-1.6-1.6-1.8-2.0-1.5
Short access total locomotion1.51.83.6-1.5-1.5-1.5-1.5-1.2-0.90.7-1.2-1.2-1.5-1.9-1.2
One hour access (0.3 mA shock)3.23.74.4-2.1-2.1-2.1-2.1-1.9-2.1-1.7-1.9-1.9-1.6-1.9-1.7
Compulsive drug intake1.31.64.1-1.0-1.0-1.0-1.0-1.4-1.5-2.0-1.4-1.4-1.1-0.8-1.2
One hour access (shock baseline)0.20.30.7-0.8-0.8-0.8-0.8-0.0-0.40.3-0.1-0.10.1-0.7-0.1
Social response proportion0.20.21.0-0.4-0.4-0.4-0.4-0.4-0.6-1.0-0.4-0.40.1-0.2-0.3
Social responses2.12.84.0-1.8-1.8-1.8-1.8-1.7-1.8-2.0-1.6-1.6-1.1-1.3-1.5
Social time4.86.67.5-2.7-2.7-2.7-2.7-2.7-2.5-2.1-2.5-2.6-2.6-2.2-2.5
Soleus weight0.00.10.2-0.2-0.2-0.2-0.2-0.2-0.3-0.5-0.2-0.2-0.40.0-0.0
Bone: stiffness2.03.34.1-1.9-1.9-1.9-1.9-1.9-2.0-1.7-1.9-1.9-1.5-1.8-1.7
Tibialis anterior weight1.13.75.01.91.91.91.91.91.91.22.02.01.62.22.2
Time to tail flick, vehicle, before self-admin0.80.81.2-0.8-0.8-0.8-0.8-1.0-0.9-0.6-1.1-1.1-1.1-1.0-1.0
Time to tail flick, vehicle, after self-admin0.00.00.10.10.10.10.1-0.2-0.3-0.4-0.2-0.20.1-0.2-0.0
Time to tail flick, test, before self-admin0.50.51.3-0.5-0.5-0.5-0.5-0.6-0.21.1-0.6-0.6-1.0-1.2-0.6
Time to tail flick, test, after self-admin0.30.30.70.40.40.40.40.80.6-0.00.70.60.70.80.6
Delta time to tail flick, vehicle, before/after SA0.80.71.11.01.01.01.00.60.60.90.80.91.10.40.9
Delta time to tail flick, test, before/after SA0.30.31.40.10.10.10.10.50.1-1.20.40.40.71.00.3
Tibia length2.67.212.8-2.8-2.8-2.8-2.8-2.6-2.9-3.6-2.6-2.6-2.2-1.7-2.2
Ambulatory time before self-admin3.04.45.8-2.2-2.2-2.2-2.2-2.2-1.9-1.4-2.2-2.2-2.4-1.9-2.2
Ambulatory time after self-admin0.81.01.8-1.0-1.0-1.0-1.0-1.1-0.6-1.1-1.0-1.0-1.3-0.3-1.1
Bone: tissue strength1.01.02.0-1.0-1.0-1.0-1.0-0.9-0.80.4-0.9-0.9-1.4-1.3-0.9
Total heroin consumption0.00.00.2-0.2-0.2-0.2-0.20.0-0.0-0.5-0.2-0.2-0.30.2-0.1
Bone: trabecular number0.10.10.50.20.20.20.20.30.30.70.30.30.1-0.00.2
Bone: trabecular spacing0.00.00.10.00.00.00.00.10.1-0.00.20.20.10.30.2
Bone: trabecular thickness0.00.00.0-0.2-0.2-0.2-0.2-0.0-0.10.0-0.1-0.1-0.0-0.1-0.0
Bone: trabecular tissue density1.11.62.21.31.31.31.31.41.20.41.31.31.41.51.4
Water consumed over 24 hours1.21.72.0-1.3-1.3-1.3-1.3-1.3-1.3-0.6-1.3-1.3-1.4-1.4-1.3
Number of responses in last shaping day0.10.10.6-0.2-0.2-0.2-0.20.30.10.70.30.30.4-0.30.2