Rngtt

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL mRNA stability Rngtt 0.5 0.03 4.1e-03 0.03 0.04 0.02 0.04 6.4e-02 5.0e-02 9.8e-02 5.1e-02
2 IC gene expression Rngtt 0.26 0.13 1.3e-06 0.1 0.12 0.1 0.11 3.7e-05 7.5e-06 7.0e-05 2.1e-05
3 Brain gene expression Rngtt 0.36 0.18 8.8e-06 0.06 0.07 0.06 0.06 1.6e-06 8.5e-07 2.7e-06 1.9e-06
4 BLA gene expression Rngtt 0.14 0.12 1.2e-04 0.09 0.07 0.1 0.1 1.4e-05 9.9e-05 5.2e-06 7.7e-06
5 PL gene expression Rngtt 0.06 0.03 5.4e-11 0.1 0.1 0.09 0.09 4.2e-11 4.6e-11 2.6e-10 2.6e-10
6 NAcc gene expression Rngtt 0.03 0.02 5.7e-06 0.03 0.03 0.03 0.03 2.8e-05 5.0e-06 5.8e-05 2.3e-05
7 Brain mRNA stability Rngtt 0.04 0.04 5.2e-04 0.02 0.03 0.02 0.03 3.2e-03 7.2e-04 1.1e-02 5.4e-04
8 Brain isoform ratio NM_001107923.2 0.02 0.02 9.8e-03 0.01 0.01 0.02 0.02 1.5e-02 1.2e-02 4.8e-03 8.5e-03
9 IL gene expression Rngtt 0.5 0.04 2.2e-04 0.04 0.03 -0.01 0.01 4.6e-02 7.8e-02 4.7e-01 1.5e-01
10 OFC gene expression Rngtt 0.2 0.1 3.2e-05 0.23 0.22 0.22 0.21 3.5e-06 7.8e-06 7.1e-06 1.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.10.20.40.70.50.50.50.40.20.20.1-0.3-0.3
Area under the delay curve0.50.61.50.5-0.0-0.7-0.6-0.4-0.6-0.81.0-1.2-1.2
BMI with tail3.612.416.73.94.04.04.13.93.73.6-2.92.32.2
BMI without tail4.112.617.14.14.13.84.14.13.83.6-2.82.32.3
Body weight5.524.032.65.75.75.55.65.55.24.9-3.83.03.0
Weight adjusted by age0.30.51.31.10.6-0.7-0.30.2-0.1-0.30.7-1.0-1.0
Bone surface0.30.61.00.80.81.00.80.90.80.8-0.60.50.5
Bone volume0.10.20.50.70.50.70.40.50.30.3-0.0-0.1-0.1
Breakpoint value in progressive ratio session1.21.53.50.20.70.50.80.91.21.4-1.91.71.6
Number of licking bursts0.30.61.6-1.3-1.0-0.8-1.1-0.7-0.5-0.3-0.10.30.4
Context. condit. distance diff. score0.60.81.2-1.0-1.1-0.3-1.1-0.9-1.0-0.90.8-0.7-0.7
Locomotion velocity, session 10.30.30.9-0.7-0.3-0.2-0.1-0.00.20.4-1.00.80.8
Locomotion distance, session 10.91.11.5-1.0-1.2-0.8-1.2-1.1-1.2-1.11.0-1.0-1.0
Locomotion velocity, session 20.00.00.00.20.1-0.00.10.10.00.1-0.2-0.2-0.2
Locomotion distance, session 21.82.53.2-1.4-1.7-1.3-1.7-1.6-1.8-1.71.4-1.6-1.6
Locomotion velocity, session 31.31.42.2-1.5-1.5-1.2-1.4-1.4-1.3-1.20.8-0.8-0.8
Locomotion distance, session 32.12.34.0-1.9-2.0-1.3-2.0-1.7-1.6-1.40.9-0.9-0.9
Stereotopy head waving bouts, day 30.30.41.01.00.90.71.00.70.50.30.10.0-0.0
Stereotopy head waving duration, day 30.70.91.71.21.21.01.31.01.00.7-0.40.50.5
Locomotion velocity, session 70.10.10.2-0.4-0.3-0.1-0.3-0.2-0.00.1-0.30.30.3
Locomotion distance, session 70.40.61.3-1.1-1.1-0.5-1.0-0.8-0.8-0.50.3-0.2-0.3
Stereotopy head waving bouts, day 70.70.82.1-0.20.20.60.40.60.80.8-1.11.41.4
Stereotopy head waving duration, day 71.41.72.30.81.11.21.31.31.41.3-1.41.51.4
Locomotion velocity, session 81.51.82.6-1.6-1.6-1.2-1.4-1.5-1.5-1.41.1-1.0-1.0
Locomotion distance, session 83.85.67.3-2.4-2.7-2.1-2.7-2.5-2.6-2.42.0-1.9-2.0
Degree of sensitization distance0.90.91.51.01.11.01.21.01.00.9-0.80.70.6
Degree of sensitization stereotypy0.60.71.8-0.20.20.50.30.50.70.8-1.11.31.3
Conditioned locomotion0.10.10.2-0.10.0-0.10.30.00.20.2-0.40.40.4
Cocaine response after cond. corrected0.30.40.9-0.10.20.10.20.40.50.7-1.00.90.9
Cocaine response after cond. not corrected0.00.10.1-0.4-0.3-0.4-0.3-0.2-0.1-0.0-0.10.20.1
Cocaine response before conditioning0.81.02.30.4-0.1-0.5-0.5-0.5-0.8-1.01.5-1.5-1.5
Saline control response0.10.10.20.10.20.20.20.30.40.4-0.50.40.5
Bone: connectivity density0.20.30.50.50.50.60.70.50.50.5-0.40.30.4
Bone: cortical apparent density0.20.30.60.2-0.0-0.7-0.3-0.3-0.4-0.60.8-0.7-0.8
Bone: cortical area2.13.26.42.52.22.42.12.11.71.5-0.70.40.4
Bone: cortical porosity0.10.10.2-0.1-0.3-0.3-0.5-0.2-0.3-0.30.4-0.2-0.3
Bone: cortical porosity0.10.10.30.60.50.50.30.50.40.4-0.10.10.1
Bone: cortical thickness0.40.61.61.31.01.30.80.90.60.40.1-0.1-0.2
Bone: cortical thickness0.30.41.10.3-0.0-0.1-0.2-0.3-0.4-0.61.0-0.9-0.9
Bone: cortical tissue density0.20.30.70.1-0.1-0.9-0.3-0.4-0.4-0.60.8-0.8-0.8
Condit. Reinf. active minus inactive responses1.41.64.1-2.0-1.8-1.2-1.7-1.4-1.2-0.90.4-0.00.0
Condit. Reinf. active-inactive response ratio1.71.84.1-2.0-1.8-1.5-1.8-1.5-1.2-1.00.4-0.1-0.0
Condit. Reinf. active responses0.60.72.2-1.5-1.2-0.6-1.2-0.7-0.6-0.4-0.10.30.4
Condit. Reinf. inactive responses0.10.10.40.40.30.60.30.40.20.2-0.1-0.0-0.0
Incentive salience index mean0.30.41.3-1.2-0.9-0.4-0.9-0.5-0.4-0.2-0.20.40.5
Condit. Reinf. lever presses0.40.51.00.40.51.00.50.90.70.8-0.70.80.8
Condit. Reinf. active minus inactive responses0.40.61.90.60.2-0.4-0.1-0.2-0.5-0.71.0-1.4-1.2
Condit. Reinf. active-inactive response ratio0.50.61.70.50.1-0.5-0.1-0.3-0.5-0.81.1-1.3-1.2
Condit. Reinf. active responses0.10.20.70.50.2-0.10.00.0-0.2-0.30.5-0.8-0.7
Condit. Reinf. inactive responses0.00.00.10.30.20.40.20.20.10.2-0.1-0.1-0.1
Condit. Reinf. lever presses0.40.51.81.30.90.50.60.70.30.10.4-0.8-0.8
Condit. Reinf. lever reinforcers received0.10.20.50.70.50.20.20.30.10.00.2-0.6-0.5
Conditioned reinforcement - actives1.11.93.70.30.61.90.51.31.31.6-1.51.81.8
Conditioned reinforcement - inactives1.42.16.31.21.12.51.21.81.31.4-1.01.11.1
Conditioned locomotion3.85.08.70.51.12.40.92.12.12.7-2.92.92.9
Patch foraging indifference point 0 sec0.10.20.3-0.10.20.50.60.30.40.4-0.60.60.5
Patch foraging indifference point AUC0.50.81.41.21.20.20.91.01.01.0-0.70.50.7
Delay disc. indifference point, 0s delay1.71.82.9-0.8-1.1-1.4-1.3-1.4-1.4-1.61.7-1.3-1.4
Delay disc. indifference point, 16s delay0.60.61.91.30.70.10.10.3-0.1-0.30.7-1.4-1.3
Delay disc. indifference point, 2s delay1.82.03.80.0-0.5-1.9-1.2-1.2-1.2-1.61.9-1.7-1.7
Delay disc. indifference point, 24s delay0.10.10.3-0.2-0.3-0.1-0.5-0.2-0.2-0.3-0.0-0.1-0.2
Delay disc. indifference point, 4s delay0.20.20.40.2-0.0-0.2-0.3-0.3-0.3-0.40.5-0.6-0.7
Delay disc. indifference point, 8s delay0.60.81.90.4-0.1-1.4-0.9-0.4-0.6-0.90.9-1.2-1.1
Indifference point function ln k0.10.10.7-0.5-0.40.8-0.0-0.1-0.10.0-0.20.30.3
Indifference point function log k0.10.10.7-0.5-0.40.8-0.0-0.1-0.10.0-0.20.30.3
Patch foraging total patch changes 0 sec0.00.10.2-0.4-0.20.00.2-0.10.10.1-0.30.40.4
Patch foraging total patch changes 12 sec1.11.43.92.01.70.81.41.41.11.0-0.3-0.00.0
Patch foraging total patch changes 18 sec0.30.51.8-0.2-0.4-1.3-0.6-0.6-0.6-0.60.8-0.7-0.7
Patch foraging total patch changes 24 sec0.30.51.31.21.00.10.80.80.70.5-0.2-0.10.1
Patch foraging total patch changes 6 sec0.30.50.70.50.70.10.90.60.80.7-0.70.80.8
Patch foraging time to switch 0 sec0.40.81.5-1.2-1.2-0.7-1.1-1.1-1.0-0.90.6-0.4-0.5
Patch foraging water rate 0 sec0.61.22.31.51.50.81.41.21.21.0-0.70.40.6
Patch foraging water rate 12 sec0.10.20.50.30.0-0.3-0.2-0.2-0.3-0.40.5-0.6-0.7
Patch foraging water rate 18 sec0.10.20.7-0.3-0.3-0.8-0.2-0.5-0.3-0.40.2-0.3-0.3
Patch foraging water rate 24 sec0.10.10.50.40.30.70.30.20.20.20.0-0.1-0.0
Patch foraging water rate 6 sec0.20.31.10.60.51.10.60.60.40.3-0.0-0.0-0.0
Seeking ratio, delayed vs. immediate footshock0.50.62.3-0.3-0.0-0.4-0.50.40.60.8-1.11.51.2
Distance traveled before self-admin0.30.40.9-0.2-0.4-1.0-0.7-0.5-0.5-0.70.7-0.6-0.6
Distance traveled after self-admin0.50.61.80.80.4-0.20.3-0.1-0.4-0.71.0-1.2-1.4
Extensor digitorum longus weight3.413.421.64.74.63.94.54.13.83.5-2.51.81.8
Bone: elastic displacement0.50.61.7-0.30.1-0.30.30.20.60.7-1.01.31.3
Bone: elastic work3.95.16.92.62.62.12.42.62.42.4-1.91.51.6
Bone: endosteal estimation2.24.98.52.92.82.02.62.52.42.2-1.61.01.1
Bone: endosteal perimeter2.35.06.12.12.32.12.32.42.42.5-2.31.91.9
Epididymis fat weight0.00.10.6-0.3-0.40.8-0.0-0.1-0.3-0.10.3-0.2-0.2
Delta time in closed arm before/after self-admin1.71.62.2-1.3-1.5-1.0-1.5-1.3-1.4-1.31.1-0.9-1.1
Delta time in open arm before/after self-admin0.60.62.51.61.20.60.60.90.60.40.3-0.4-0.4
Diff in mean of infusions in LGA sessions0.10.10.2-0.5-0.3-0.1-0.4-0.1-0.00.2-0.30.40.4
Delay discount exponential model param0.40.40.9-0.40.00.70.60.30.40.7-0.80.90.9
Extinction: sum of active levers before priming0.10.10.6-0.4-0.3-0.7-0.3-0.5-0.3-0.1-0.30.0-0.1
Active lever presses in extinction session 60.50.51.0-0.2-0.4-0.9-0.5-0.7-0.7-0.70.4-1.0-1.0
Bone: final force1.42.35.22.32.02.01.71.81.31.2-0.6-0.00.1
Bone: final moment2.33.88.83.02.52.42.22.31.81.6-0.70.00.1
Food consumed during 24 hour testing period1.01.43.92.01.61.31.41.31.00.8-0.1-0.1-0.2
Glucose0.30.51.20.10.31.10.50.70.60.7-0.80.80.9
Heart weight0.60.91.60.91.01.30.91.11.01.1-0.90.70.7
Delay discount hyperbolic model param0.40.51.0-0.40.00.90.60.40.50.7-0.80.91.0
Intermittent access intake day 1-15 change1.42.94.6-0.6-1.2-1.5-1.8-1.4-1.8-1.82.0-2.1-2.1
Intermittent access intake escalation1.22.53.4-0.8-1.3-1.6-1.5-1.4-1.7-1.71.8-1.9-1.8
Intermittent access intake escalation 21.82.02.9-0.4-0.9-1.6-1.6-1.1-1.4-1.51.7-1.7-1.7
Intermitt. access day 1 inactive lever presses0.10.51.1-1.1-1.0-0.1-0.5-0.8-0.8-0.70.3-0.5-0.5
Intermitt. access day 15 inactive lever presses0.00.00.20.20.00.5-0.00.40.10.2-0.00.0-0.0
Intermitt. access escalation Index0.10.10.30.50.40.60.50.40.20.4-0.1-0.1-0.1
Intermittent access day 1 total infusions1.93.03.90.91.41.91.61.71.81.8-1.91.92.0
Intermittent access day 15 total infusions0.20.20.50.70.60.60.60.60.50.4-0.10.00.1
Intermittent access terminal intake (last 3 days)0.00.00.2-0.2-0.10.10.10.10.10.2-0.20.40.4
Intermittent access total infusions2.42.83.80.81.31.71.71.61.71.8-1.82.02.0
Intermittent access day 1 locomotion3.03.87.00.21.01.91.31.61.92.1-2.62.62.7
Intermittent access day 15 total locomotion0.91.72.40.60.91.60.81.41.31.4-1.51.51.5
Intermittent access total locomotion1.82.14.00.20.71.50.81.41.41.6-1.92.02.0
Intermittent access standard deviation0.10.20.8-0.3-0.5-0.0-0.9-0.2-0.5-0.30.3-0.5-0.5
Left kidney weight0.83.911.13.32.82.02.02.31.81.6-0.6-0.1-0.1
Right kidney weight0.73.29.43.12.52.02.21.91.51.3-0.1-0.4-0.6
Cocaine induced anxiety0.60.82.6-1.6-1.4-0.5-0.8-1.1-0.9-0.70.3-0.1-0.1
Post-drug Anxiety0.10.20.7-0.8-0.5-0.00.1-0.4-0.2-0.2-0.00.50.5
Baseline Anxiety0.80.92.31.51.31.21.21.10.80.70.1-0.0-0.0
Tail length1.24.57.22.62.72.02.52.32.32.0-1.41.31.3
Length with tail1.87.913.73.73.62.93.13.23.02.7-1.81.41.4
Length without tail0.72.34.62.11.92.11.91.71.41.3-0.60.10.2
Times rat made contact with spout0.10.20.40.1-0.1-0.2-0.4-0.2-0.3-0.30.7-0.5-0.6
Lifetime Intake2.32.93.50.91.41.91.81.61.71.8-1.81.91.9
Liver weight, left0.61.02.01.41.21.31.11.10.91.0-0.70.20.1
Liver weight, right0.71.22.61.61.51.21.51.21.10.8-0.40.30.2
Locomotor activity0.30.51.9-1.4-1.00.0-0.6-0.5-0.4-0.1-0.50.60.4
Locomotor testing distance0.10.20.4-0.6-0.6-0.3-0.5-0.5-0.4-0.40.2-0.2-0.3
Locomotor testing rearing1.12.32.7-1.1-1.4-1.3-1.5-1.6-1.6-1.61.6-1.5-1.6
Locomotion in novel chamber0.60.72.91.71.3-0.30.90.60.40.00.4-0.9-0.7
Locomotion in novel chamber post-restriction0.20.31.41.20.90.20.50.50.60.5-0.10.0-0.1
Fecal boli incidents, locomotor time 10.20.30.6-0.2-0.4-0.2-0.1-0.6-0.6-0.60.6-0.8-0.8
Change in fecal boli incidents, locomotor task0.10.10.30.60.5-0.4-0.20.40.40.20.2-0.20.3
Time >=10cm from walls, locomotor time 10.10.10.4-0.6-0.60.2-0.4-0.2-0.3-0.1-0.0-0.20.1
Bouts of movement, locomotor time 10.30.41.20.50.10.2-0.1-0.1-0.4-0.51.0-1.1-0.9
Total resting periods, locomotor time 10.30.31.20.40.10.1-0.1-0.1-0.4-0.50.9-1.1-0.8
Rest time, locomotor task time 10.00.00.1-0.0-0.10.00.1-0.1-0.2-0.30.3-0.4-0.4
Distance moved, locomotor task time 10.00.00.1-0.00.0-0.3-0.2-0.00.0-0.1-0.00.20.1
Vertical activity count, locomotor time 10.10.20.4-0.3-0.4-0.4-0.6-0.4-0.5-0.60.6-0.4-0.4
Time >=10cm from walls, locomotor time 20.00.10.3-0.10.0-0.20.3-0.00.20.2-0.20.20.5
Bouts of movement, locomotor time 20.71.12.11.21.31.21.41.11.10.8-0.50.60.5
Total resting periods, locomotor time 20.61.12.01.41.31.31.41.21.00.8-0.40.40.3
Rest time, locomotor task time 20.40.51.10.50.61.10.70.80.70.8-0.70.70.4
Distance moved, locomotor task time 20.20.30.9-0.9-0.6-0.4-0.5-0.5-0.2-0.1-0.20.40.6
Vertical activity count, locomotor time 20.10.10.5-0.5-0.20.00.0-0.00.10.1-0.40.50.7
Light reinforcement 11.12.87.42.72.51.02.01.91.71.4-0.70.40.3
Light reinforcement 20.71.01.60.81.01.01.31.11.01.0-1.00.90.9
Bone: marrow area2.14.78.42.92.81.92.52.52.32.2-1.51.01.1
Bone: maximum diameter2.44.56.02.32.42.32.32.42.32.2-1.81.51.4
Bone: maximum force2.44.28.52.92.62.62.42.52.01.8-1.00.40.5
Bone: maximum moment3.25.512.23.53.12.92.72.82.22.0-1.00.30.4
Mean time between licks in bursts0.30.71.81.41.20.71.00.90.80.6-0.2-0.10.1
Mean num. licks in bursts0.40.72.11.41.00.60.90.60.30.10.7-0.9-0.9
Cd content in liver2.32.64.80.61.20.91.21.41.71.9-2.22.02.1
Co content in liver0.10.20.80.1-0.0-0.9-0.2-0.3-0.2-0.30.3-0.5-0.4
Cu content in liver0.20.20.9-0.9-0.6-0.1-0.2-0.3-0.10.0-0.40.50.6
Fe content in liver0.10.10.4-0.2-0.2-0.00.1-0.3-0.3-0.40.6-0.2-0.3
K content in liver0.90.81.1-0.7-0.9-0.9-0.8-1.0-1.0-1.00.9-0.8-1.0
Mg content in liver0.10.10.5-0.7-0.6-0.3-0.4-0.4-0.3-0.30.00.20.1
Mn content in liver0.10.20.50.50.40.70.50.50.30.3-0.10.20.1
Na content in liver2.32.53.6-1.8-1.9-1.4-1.6-1.8-1.7-1.71.4-1.1-1.1
Rb content in liver2.02.33.3-1.2-1.5-1.1-1.2-1.6-1.7-1.81.8-1.6-1.5
Se content in liver4.55.37.0-1.9-2.3-2.1-2.2-2.5-2.5-2.62.6-2.0-2.1
Sr content in liver1.21.11.4-1.0-1.1-1.0-1.2-1.1-1.1-1.11.0-0.8-0.8
Zn content in liver0.10.20.4-0.5-0.2-0.6-0.0-0.10.10.2-0.60.50.6
Bone: minimum diameter1.32.44.12.01.82.01.81.81.51.6-1.00.60.6
Time in familiar zone, hab. session 11.91.82.21.01.31.01.31.41.51.4-1.41.51.4
Time in novel zone, hab. session 16.36.37.5-2.1-2.5-2.4-2.7-2.7-2.7-2.62.5-2.4-2.3
Total zone transitions, hab. session 13.14.48.1-2.8-2.8-1.4-2.4-2.3-2.3-2.11.4-1.2-1.2
Total locomotion distance, hab. session 13.44.86.3-2.0-2.4-1.3-2.3-2.2-2.5-2.42.3-2.2-2.2
Locomotion velocity, hab. session 11.92.73.8-1.7-1.9-0.8-1.7-1.7-1.9-1.81.6-1.5-1.5
Time in familiar zone, hab. session 20.70.81.71.31.11.11.21.00.80.7-0.3-0.10.0
Time in novel zone, hab. session 20.40.40.7-0.6-0.7-0.9-0.8-0.7-0.7-0.70.7-0.4-0.5
Total zone transitions, hab. session 20.70.91.7-1.3-1.3-0.6-1.2-1.0-1.1-0.90.6-0.6-0.6
Total locomotion distance, hab. session 20.50.61.1-0.3-0.6-0.1-0.7-0.5-0.8-0.81.1-1.1-1.0
Locomotion velocity, hab. session 20.30.40.6-0.5-0.7-0.1-0.7-0.5-0.8-0.70.8-0.8-0.8
Novel to familiar place preference ratio0.10.10.4-0.7-0.5-0.1-0.2-0.3-0.3-0.2-0.00.10.1
Novelty place preference0.50.51.0-1.0-0.9-0.7-0.7-0.8-0.8-0.70.5-0.4-0.4
Time in novel zone, NPP test0.80.81.1-1.1-1.1-0.8-0.9-1.0-1.0-1.00.8-0.6-0.6
Total zone transitions, NPP test1.42.13.3-1.7-1.8-0.9-1.6-1.5-1.7-1.51.1-1.1-1.1
Total locomotion distance, NPP test0.30.50.7-0.6-0.70.0-0.6-0.6-0.8-0.70.8-0.8-0.8
Locomotion velocity, NPP test0.10.10.2-0.3-0.40.3-0.2-0.2-0.4-0.30.4-0.4-0.4
Intraocular pressure6.99.913.72.53.02.32.43.43.53.7-3.63.43.5
Delta distance traveled before/after self-admin0.30.31.00.80.70.71.00.50.30.00.1-0.2-0.3
Delta ambulatory time before/after self-admin0.20.30.90.80.70.61.00.50.40.2-0.10.1-0.1
Parametrial fat weight0.00.10.2-0.4-0.40.3-0.3-0.5-0.3-0.30.5-0.1-0.2
Pavlov. Cond. lever latency2.63.24.7-1.1-1.5-2.2-1.7-1.9-1.8-2.02.2-1.7-1.7
Pavlov. Cond. magazine entry latency1.31.72.31.31.41.41.21.51.41.4-1.11.11.1
Pavlov. Cond. change in total contacts0.10.10.4-0.0-0.00.6-0.10.30.20.3-0.40.20.3
Pavlov. Cond. index score2.12.63.61.11.31.91.41.71.71.8-1.81.71.7
Pavlov. Cond. latency score2.73.54.61.11.52.11.61.91.92.1-2.22.02.0
Pavlov. Cond. lever contacts2.53.04.31.31.52.11.71.91.81.9-2.01.61.5
Pavlov. Cond. magazine entry number1.92.43.6-1.5-1.6-1.9-1.4-1.8-1.7-1.71.3-1.3-1.3
Pavlov. Cond. intertrial magazine entries3.94.77.6-1.1-1.7-1.9-1.9-2.1-2.3-2.42.5-2.7-2.7
Pavlov. Cond. lever-magazine prob. diff.1.51.92.71.01.21.61.21.51.41.5-1.51.31.3
Pavlov. Cond. response bias1.72.13.51.51.51.91.41.71.51.5-1.31.01.0
Pavlov. Cond. lever latency0.40.51.5-0.9-0.40.10.0-0.10.30.4-0.91.21.2
Pavlov. Cond. magazine entry latency0.70.81.7-0.3-0.6-0.4-0.8-0.6-1.0-1.11.2-1.2-1.3
Pavlov. Cond. change in total contacts0.30.61.80.90.4-0.3-0.2-0.0-0.3-0.51.0-1.3-1.2
Pavlov. Cond. index score0.40.61.50.3-0.1-0.3-0.5-0.3-0.6-0.71.0-1.2-1.2
Pavlov. Cond. latency score0.10.10.40.60.30.2-0.10.3-0.0-0.10.4-0.6-0.6
Pavlov. Cond. lever contacts0.50.62.00.90.4-0.1-0.10.0-0.4-0.61.1-1.4-1.4
Pavlov. Cond. magazine entry number0.70.92.3-0.10.30.20.60.50.91.0-1.41.51.5
Pavlov. Cond. intertrial magazine entries0.10.10.4-0.5-0.3-0.1-0.2-0.10.10.2-0.50.60.6
Pavlov. Cond. lever-magazine prob. diff.0.50.61.70.3-0.1-0.3-0.5-0.3-0.7-0.81.1-1.3-1.3
Pavlov. Cond. response bias1.11.54.40.6-0.1-0.5-0.5-0.5-1.0-1.21.8-2.1-2.1
Time in closed arm before self-admin0.91.22.61.61.60.81.51.21.10.9-0.60.30.3
Time in closed arm after self-admin0.10.10.3-0.3-0.3-0.5-0.5-0.3-0.3-0.2-0.0-0.0-0.1
Time in open arm before self-admin0.91.03.3-1.8-1.4-0.5-1.2-0.8-0.5-0.2-0.20.90.8
Time in open arm after self-admin0.20.30.40.50.50.60.30.60.60.6-0.30.50.5
Bone: periosteal estimation2.96.211.53.43.22.72.82.92.62.4-1.51.01.0
Bone: periosteal perimeter4.57.79.92.93.03.13.03.12.92.9-2.52.02.0
Bone: post-yield work0.40.61.81.31.00.80.80.80.50.30.3-0.5-0.4
Progressive ratio test 1 active lever presses2.63.27.41.21.52.71.91.91.81.8-1.41.61.6
Progressive ratio test 1 breakpoint2.53.17.51.21.52.71.81.91.71.8-1.31.61.6
Progressive ratio test 1 inactive lever presses0.10.10.3-0.3-0.20.6-0.10.30.00.3-0.40.30.3
Progressive ratio test 2 active lever presses0.60.71.41.21.11.01.01.00.80.7-0.20.30.3
Progressive ratio test 2 breakpoint0.60.71.21.11.01.01.10.90.80.7-0.20.40.4
Progressive ratio test 2 inactive lever presses1.11.85.51.01.02.30.91.61.21.4-1.11.01.0
Incentive Sensitization - Responses0.50.82.71.61.10.40.70.60.30.00.9-1.0-1.0
Incentive Sensitization - Breakpoint0.60.72.71.61.10.30.70.70.40.10.7-0.9-0.8
Sum of active levers in priming session hrs 5-60.70.62.2-0.20.3-0.20.60.30.60.8-1.51.11.0
Progressive ratio0.71.12.31.21.21.21.51.11.01.1-0.90.40.5
Food seeking constrained by brief footshock1.01.22.31.51.5-0.21.01.01.31.1-1.00.80.9
Seeking ratio, punishment vs. effort0.60.83.1-0.5-0.6-1.8-1.3-0.9-0.7-0.90.8-0.3-0.4
Retroperitoneal fat weight0.83.44.9-2.1-2.2-1.2-1.9-2.2-2.0-2.01.8-1.4-1.4
Reaction time number correct0.30.61.6-0.20.20.50.30.60.70.8-1.21.21.3
Reaction time mean minus median0.20.40.9-0.2-0.40.30.0-0.6-0.6-0.60.9-0.9-1.0
Reaction time mean minus median AUC0.30.92.0-0.4-0.6-0.3-0.3-0.9-1.0-1.11.4-1.2-1.3
Reaction time num false alarms1.21.82.80.40.81.61.01.31.31.4-1.51.71.6
Reaction time num false alarms AUC1.21.93.50.20.71.41.01.21.41.5-1.81.81.9
Reaction time trials correct on left0.30.61.6-0.20.20.50.30.60.70.8-1.21.21.3
Reaction time trials on left0.40.71.7-0.10.30.50.40.70.80.8-1.21.31.3
Reaction time mean0.81.32.30.50.81.51.21.01.11.2-1.21.31.2
Reaction time mean AUC0.50.71.40.30.51.20.90.70.80.9-0.91.01.0
Median of all reaction times1.72.43.50.51.01.81.51.41.51.7-1.81.91.8
Reaction time omissions0.50.71.20.60.71.01.10.80.80.8-0.80.80.7
Reaction time false alarm rate0.60.81.50.00.41.00.60.70.81.0-1.11.21.2
Reaction time premature initiation rate0.20.30.80.80.70.70.90.50.40.3-0.1-0.0-0.1
Reaction time premature initiations0.50.91.50.91.01.11.21.01.00.9-0.80.60.6
Std. dev. reaction times0.00.10.2-0.5-0.40.2-0.1-0.4-0.3-0.20.2-0.1-0.2
Reaction time trials completed0.40.71.7-0.10.30.50.40.70.80.8-1.21.31.3
Reaction time trials AUC0.30.61.4-0.10.30.60.40.70.70.8-1.11.11.2
Run reversals in cocaine runway, females0.50.51.20.10.40.60.40.50.70.9-1.01.11.0
Run reversals in cocaine runway, males0.10.10.3-0.6-0.5-0.0-0.1-0.4-0.4-0.30.1-0.2-0.2
Latency to leave start box in cocaine runway0.30.31.31.10.9-0.30.30.50.40.2-0.0-0.2-0.3
Latency to leave start box in cocaine runway, F0.10.20.40.70.60.10.30.50.40.3-0.30.20.1
Latency to leave start box in cocaine runway, M0.50.41.60.60.3-1.3-0.6-0.2-0.3-0.40.7-0.9-0.8
Std. dev. time between licks in bursts0.30.31.21.10.80.60.60.60.50.30.1-0.4-0.2
Total sessions with >9 infusions2.83.47.20.61.22.71.91.71.81.8-1.92.12.1
Short access day 1 total inactive lever presses1.21.63.50.30.71.91.21.11.11.3-1.51.41.4
Short access day 10 total inactive lever presses1.53.66.2-2.5-2.4-2.0-2.0-2.2-2.0-1.81.2-1.1-1.0
Short access day 1 total infusions0.50.62.6-0.00.31.60.90.50.60.6-0.60.80.8
Short access day 10 total infusions1.01.22.50.00.51.21.10.81.01.1-1.31.61.5
Short access total infusions2.12.65.00.61.12.21.91.41.61.6-1.61.81.7
Short access day 1 locomotion0.40.52.30.00.21.50.60.60.40.7-0.80.50.6
Short access day 10 total locomotion1.32.44.9-0.30.41.61.11.01.31.6-2.22.22.2
Short access total locomotion3.44.17.8-0.20.72.51.81.41.72.1-2.62.82.7
One hour access (0.3 mA shock)0.60.72.51.30.81.60.30.90.30.30.5-0.5-0.6
Compulsive drug intake0.20.30.90.4-0.0-0.1-0.5-0.1-0.4-0.40.7-0.9-0.8
One hour access (shock baseline)0.40.62.10.40.61.41.00.70.70.7-0.50.70.6
Social response proportion1.61.82.8-1.6-1.7-1.1-1.5-1.3-1.5-1.41.2-1.0-0.9
Social responses1.31.73.6-0.2-0.8-0.8-1.2-0.9-1.3-1.41.8-1.9-1.8
Social time0.70.92.1-0.3-0.7-1.0-1.4-0.7-0.9-0.81.1-1.0-1.1
Soleus weight1.13.25.42.32.31.52.02.11.91.9-1.41.01.0
Bone: stiffness0.30.41.01.00.50.90.20.4-0.1-0.10.7-0.9-0.9
Tibialis anterior weight4.916.728.55.35.24.14.84.74.33.9-2.72.02.0
Time to tail flick, vehicle, before self-admin0.10.10.2-0.2-0.2-0.4-0.4-0.2-0.2-0.10.1-0.0-0.0
Time to tail flick, vehicle, after self-admin0.30.41.0-0.8-0.4-0.5-0.5-0.10.20.3-1.01.01.0
Time to tail flick, test, before self-admin2.52.64.30.71.21.61.61.51.71.8-1.62.02.1
Time to tail flick, test, after self-admin0.90.91.61.21.30.21.01.11.10.9-0.70.70.7
Delta time to tail flick, vehicle, before/after SA0.20.20.6-0.7-0.5-0.8-0.4-0.5-0.2-0.2-0.30.30.3
Delta time to tail flick, test, before/after SA0.40.41.30.4-0.0-0.4-0.4-0.2-0.5-0.60.8-1.0-1.1
Tibia length1.23.26.92.62.32.02.02.21.81.6-0.90.40.5
Ambulatory time before self-admin0.60.92.1-0.3-0.5-1.4-0.8-0.9-0.9-1.11.0-1.1-1.0
Ambulatory time after self-admin0.50.62.01.41.10.11.10.40.2-0.20.5-0.8-1.0
Bone: tissue strength0.50.51.40.3-0.2-0.0-0.5-0.2-0.6-0.70.9-1.2-1.2
Total heroin consumption1.21.42.91.71.51.31.51.41.11.1-0.90.20.2
Bone: trabecular number0.20.30.80.1-0.1-0.1-0.2-0.3-0.4-0.50.8-0.9-0.8
Bone: trabecular spacing0.60.81.10.80.90.51.10.91.01.0-1.00.90.9
Bone: trabecular thickness0.10.10.50.40.20.7-0.00.30.00.00.3-0.3-0.3
Bone: trabecular tissue density4.77.09.0-2.0-2.5-2.3-2.7-2.7-2.9-3.03.0-2.6-2.6
Water consumed over 24 hours0.50.72.51.61.20.80.71.00.70.60.1-0.2-0.3
Number of responses in last shaping day1.21.31.91.41.41.31.21.31.21.2-0.80.50.6