Hub : Genes

Rnf39

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Rnf39	0.04	0.03	2.3e-03	0.01	0.01	0.01	0.01	1.0e-02	8.8e-03	5.7e-02	2.9e-02
2	PL	mRNA stability	Rnf39	0.05	0.03	4.6e-05	0.04	0.03	0.02	0.04	9.5e-06	1.4e-04	1.2e-03	7.5e-05
3	Brain	mRNA stability	Rnf39	0.05	0.03	1.2e-05	0.05	0.05	0.05	0.05	8.4e-06	2.3e-05	3.7e-05	2.5e-05
4	pVTA	gene expression	Rnf39	0.07	0.05	9.5e-04	0.03	0.01	0.04	0.02	1.1e-03	5.8e-02	6.2e-04	4.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.0	1.6	2.7	-1.0	1.5	1.6	0.9
Area under the delay curve	2.1	2.4	3.6	-0.0	-1.7	-1.9	1.8
BMI with tail	0.7	2.6	4.5	-2.1	-1.7	-1.4	-0.8
BMI without tail	1.4	4.3	9.6	-1.2	-3.1	-2.5	0.2
Body weight	3.2	13.9	28.5	1.5	-5.3	-5.0	-0.1
Weight adjusted by age	1.8	2.8	3.1	1.5	-1.7	-1.7	1.8
Bone surface	0.6	1.0	1.9	1.3	-0.4	-0.4	1.4
Bone volume	0.4	0.8	3.0	0.3	-0.2	-0.1	1.7
Breakpoint value in progressive ratio session	1.6	1.9	5.8	-0.8	0.5	0.9	-2.4
Number of licking bursts	0.2	0.3	1.1	1.1	0.2	-0.3	-0.3
Context. condit. distance diff. score	4.0	4.9	7.5	2.1	2.7	2.3	-1.5
Locomotion velocity, session 1	0.2	0.2	0.9	0.9	0.2	0.0	-0.0
Locomotion distance, session 1	0.7	0.9	1.3	-1.2	1.0	1.0	-0.2
Locomotion velocity, session 2	0.5	0.6	1.9	0.2	-0.2	-0.6	-1.4
Locomotion distance, session 2	0.4	0.6	1.2	-0.3	1.0	1.1	-0.3
Locomotion velocity, session 3	0.4	0.5	1.3	-1.2	0.1	-0.2	-0.7
Locomotion distance, session 3	1.1	1.2	2.4	-0.5	1.5	1.4	-0.6
Stereotopy head waving bouts, day 3	1.0	1.2	1.9	1.4	-1.0	-1.1	-0.7
Stereotopy head waving duration, day 3	0.8	0.9	1.5	1.0	-1.1	-1.2	-0.3
Locomotion velocity, session 7	2.1	2.3	6.1	0.3	2.5	1.7	0.3
Locomotion distance, session 7	2.0	2.5	5.7	-0.5	2.4	2.0	0.3
Stereotopy head waving bouts, day 7	1.9	2.2	3.9	0.7	-1.6	-2.0	1.3
Stereotopy head waving duration, day 7	2.0	2.4	4.2	0.7	-1.8	-2.1	1.2
Locomotion velocity, session 8	2.0	2.4	8.9	3.0	-0.2	-0.5	-0.7
Locomotion distance, session 8	2.4	3.5	5.2	1.6	2.3	2.3	-1.2
Degree of sensitization distance	0.3	0.3	1.0	1.0	0.2	-0.0	0.4
Degree of sensitization stereotypy	0.9	0.9	1.6	0.3	-0.9	-1.3	1.1
Conditioned locomotion	1.4	1.7	3.8	0.2	-1.7	-2.0	-0.2
Cocaine response after cond. corrected	0.4	0.5	1.3	-0.7	0.4	0.1	-1.2
Cocaine response after cond. not corrected	0.5	0.6	1.1	0.7	-0.8	-1.0	-0.6
Cocaine response before conditioning	5.1	6.1	7.4	2.3	-2.7	-2.7	2.2
Saline control response	1.7	2.2	4.3	-1.1	-1.4	-1.2	2.1
Bone: connectivity density	1.3	2.0	3.9	-0.1	2.0	2.0	0.6
Bone: cortical apparent density	0.6	0.9	2.5	-1.6	-0.6	-0.5	0.6
Bone: cortical area	0.6	1.0	2.0	0.8	-1.4	-0.8	0.7
Bone: cortical porosity	0.1	0.1	0.3	-0.1	-0.4	-0.3	0.5
Bone: cortical porosity	0.4	0.4	0.5	0.7	-0.6	-0.5	0.7
Bone: cortical thickness	1.3	2.1	3.3	-1.8	-1.7	-0.9	1.1
Bone: cortical thickness	1.3	1.5	5.4	-2.3	-0.5	-0.1	0.6
Bone: cortical tissue density	0.5	0.7	2.1	-1.4	-0.5	-0.5	0.5
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.0	0.3	0.2	-0.3
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.6	-0.8	-0.6	-0.7	-0.2
Condit. Reinf. active responses	0.5	0.7	1.0	-0.3	1.0	1.0	-0.8
Condit. Reinf. inactive responses	2.0	2.5	4.4	-1.1	1.9	2.1	-0.8
Incentive salience index mean	1.0	1.2	2.8	0.9	0.9	0.7	-1.7
Condit. Reinf. lever presses	3.7	5.2	11.1	1.5	2.0	1.9	-3.3
Condit. Reinf. active minus inactive responses	0.8	1.1	1.4	0.9	-1.2	-1.2	0.9
Condit. Reinf. active-inactive response ratio	1.6	1.9	3.5	1.1	-1.6	-1.9	0.4
Condit. Reinf. active responses	0.1	0.2	0.3	0.6	0.2	0.4	0.4
Condit. Reinf. inactive responses	0.7	1.0	2.4	-0.2	1.1	1.6	-0.1
Condit. Reinf. lever presses	1.0	1.5	3.0	0.6	1.5	1.7	0.5
Condit. Reinf. lever reinforcers received	0.2	0.3	0.5	0.7	0.4	0.6	0.2
Conditioned reinforcement - actives	1.7	2.9	9.1	-0.8	-1.1	-0.9	3.0
Conditioned reinforcement - inactives	1.0	1.5	4.3	-0.9	-0.8	-0.4	2.1
Conditioned locomotion	0.8	1.1	3.5	0.2	-0.6	-0.5	1.9
Patch foraging indifference point 0 sec	0.9	1.7	6.1	-0.8	0.4	0.3	2.5
Patch foraging indifference point AUC	1.0	1.5	3.3	0.5	-1.8	-1.3	0.9
Delay disc. indifference point, 0s delay	1.0	1.0	2.1	0.6	-1.2	-1.4	-0.7
Delay disc. indifference point, 16s delay	2.8	3.1	6.6	-1.7	-1.3	-1.1	2.6
Delay disc. indifference point, 2s delay	1.8	2.0	4.5	0.6	-1.7	-2.1	0.4
Delay disc. indifference point, 24s delay	1.3	1.4	3.7	-0.3	-0.8	-1.1	1.9
Delay disc. indifference point, 4s delay	3.0	3.2	5.7	0.8	-2.3	-2.4	1.0
Delay disc. indifference point, 8s delay	0.9	1.1	3.8	0.1	-0.4	-0.6	2.0
Indifference point function ln k	0.3	0.6	1.0	1.0	1.0	0.5	-0.1
Indifference point function log k	0.3	0.6	1.0	1.0	1.0	0.5	-0.1
Patch foraging total patch changes 0 sec	1.3	2.4	8.4	-1.0	0.2	0.2	2.9
Patch foraging total patch changes 12 sec	1.0	1.4	3.6	-1.2	-0.7	0.1	1.9
Patch foraging total patch changes 18 sec	0.9	1.4	3.8	-1.9	0.7	1.0	0.6
Patch foraging total patch changes 24 sec	1.9	3.2	7.5	-2.1	0.6	0.7	2.7
Patch foraging total patch changes 6 sec	1.8	2.8	7.5	-1.6	-0.8	-0.5	2.7
Patch foraging time to switch 0 sec	0.6	1.2	3.5	-1.9	0.5	0.3	-1.0
Patch foraging water rate 0 sec	0.9	1.9	6.8	0.6	-0.6	-0.3	2.6
Patch foraging water rate 12 sec	0.2	0.3	0.8	-0.7	0.1	0.1	0.9
Patch foraging water rate 18 sec	0.2	0.2	0.8	0.3	-0.1	-0.3	0.9
Patch foraging water rate 24 sec	0.3	0.5	0.9	-0.1	-0.8	-0.5	0.9
Patch foraging water rate 6 sec	0.4	0.6	1.6	-0.8	-0.0	0.4	1.3
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.0	0.2	-0.8	-0.9	-1.0
Distance traveled before self-admin	0.6	0.8	1.9	1.4	-0.2	0.5	-1.0
Distance traveled after self-admin	0.9	1.1	2.2	1.1	-0.7	-0.6	-1.5
Extensor digitorum longus weight	0.5	2.1	4.3	2.0	0.3	0.0	2.1
Bone: elastic displacement	0.5	0.6	0.7	-0.7	-0.6	-0.9	0.9
Bone: elastic work	0.7	1.0	2.2	-0.3	-1.5	-1.2	0.4
Bone: endosteal estimation	2.9	6.3	16.2	4.0	-1.9	-2.3	-0.1
Bone: endosteal perimeter	1.7	3.6	14.2	3.8	0.1	-0.1	-0.5
Epididymis fat weight	3.7	12.8	44.1	-6.6	-1.2	-0.4	2.3
Delta time in closed arm before/after self-admin	0.3	0.3	0.5	-0.3	-0.6	-0.7	0.6
Delta time in open arm before/after self-admin	0.2	0.2	0.5	0.5	-0.4	0.0	0.7
Diff in mean of infusions in LGA sessions	2.5	3.0	5.0	-1.0	2.2	2.0	-1.5
Delay discount exponential model param	2.2	2.5	3.7	0.0	1.7	1.9	-1.8
Extinction: sum of active levers before priming	1.8	2.0	3.8	-1.0	1.1	1.4	-2.0
Active lever presses in extinction session 6	1.4	1.4	4.1	-2.0	-0.2	0.4	-1.2
Bone: final force	1.4	2.2	5.0	-0.7	-2.2	-1.7	0.7
Bone: final moment	1.2	1.9	4.1	-0.4	-2.0	-1.5	1.1
Food consumed during 24 hour testing period	0.6	0.9	1.7	1.3	-0.9	-0.8	-0.5
Glucose	3.0	4.7	15.6	3.9	1.5	0.7	-0.7
Heart weight	2.0	3.1	5.3	0.4	-2.1	-2.3	1.5
Delay discount hyperbolic model param	2.2	2.4	3.9	0.0	1.7	2.0	-1.7
Intermittent access intake day 1-15 change	0.0	0.0	0.2	0.0	0.0	0.0	-0.4
Intermittent access intake escalation	0.1	0.2	0.3	-0.5	-0.5	-0.5	-0.2
Intermittent access intake escalation 2	0.4	0.4	1.6	1.3	-0.0	-0.0	0.0
Intermitt. access day 1 inactive lever presses	0.2	0.9	2.0	1.4	-0.0	0.0	-1.2
Intermitt. access day 15 inactive lever presses	0.4	0.7	1.3	1.2	-0.3	-1.0	0.7
Intermitt. access escalation Index	2.4	3.4	8.8	-0.4	1.4	1.6	-3.0
Intermittent access day 1 total infusions	0.5	0.8	2.2	-1.5	0.0	0.3	1.0
Intermittent access day 15 total infusions	0.6	0.8	2.2	-1.5	-0.9	-0.6	0.4
Intermittent access terminal intake (last 3 days)	1.1	1.4	2.6	-1.4	-0.8	-0.7	1.6
Intermittent access total infusions	0.9	1.1	2.2	-1.1	-0.7	-0.6	1.5
Intermittent access day 1 locomotion	0.2	0.2	0.4	-0.5	-0.6	-0.4	-0.1
Intermittent access day 15 total locomotion	1.2	2.2	4.6	0.3	-2.1	-2.0	0.3
Intermittent access total locomotion	1.4	1.7	3.6	0.1	-1.9	-1.8	0.4
Intermittent access standard deviation	1.5	3.2	9.7	-0.3	-1.4	-0.9	3.1
Left kidney weight	1.9	8.8	18.1	1.2	-4.3	-3.8	1.0
Right kidney weight	2.7	12.1	23.0	1.6	-4.8	-4.6	1.5
Cocaine induced anxiety	0.9	1.3	3.0	1.7	0.8	0.6	-1.0
Post-drug Anxiety	1.1	1.1	2.2	1.0	0.9	0.7	-1.5
Baseline Anxiety	1.2	1.3	3.6	-1.9	0.8	0.8	-0.7
Tail length	3.1	12.0	17.1	4.1	-4.1	-3.7	0.4
Length with tail	4.4	19.0	27.5	5.2	-5.0	-4.7	1.1
Length without tail	3.1	10.1	17.0	2.9	-3.9	-4.1	0.2
Times rat made contact with spout	1.6	1.8	3.1	-1.8	1.4	1.5	-0.2
Lifetime Intake	1.0	1.2	2.2	-1.0	-1.0	-0.7	1.5
Liver weight, left	2.2	3.7	9.3	3.0	-0.9	-0.7	-2.0
Liver weight, right	2.9	5.1	10.0	3.2	-2.0	-2.4	-0.9
Locomotor activity	1.8	2.8	10.3	3.2	-0.7	-0.6	0.3
Locomotor testing distance	0.9	1.6	4.8	2.2	0.3	0.0	1.2
Locomotor testing rearing	0.5	0.9	3.2	1.8	-0.6	-0.2	-0.3
Locomotion in novel chamber	0.2	0.3	0.6	0.3	-0.8	-0.3	0.7
Locomotion in novel chamber post-restriction	0.5	0.8	1.6	-0.0	-1.1	-1.3	0.6
Fecal boli incidents, locomotor time 1	0.3	0.5	1.3	-0.1	1.1	0.8	-0.1
Change in fecal boli incidents, locomotor task	1.0	1.0	2.4	0.2	-1.3	-1.6	-0.2
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.5	1.2	-0.8	-0.8	-1.0
Bouts of movement, locomotor time 1	0.7	0.8	1.3	1.1	0.9	0.7	0.8
Total resting periods, locomotor time 1	0.4	0.4	1.2	1.1	0.4	0.2	0.4
Rest time, locomotor task time 1	0.8	1.1	1.5	1.2	-0.8	-1.0	-1.0
Distance moved, locomotor task time 1	0.3	0.5	1.9	-0.4	-0.1	0.1	1.4
Vertical activity count, locomotor time 1	0.2	0.6	2.1	-0.2	0.0	0.4	1.4
Time >=10cm from walls, locomotor time 2	0.4	0.6	1.0	1.0	-0.7	-0.8	0.2
Bouts of movement, locomotor time 2	0.9	1.4	3.0	1.7	-1.3	-0.7	-0.4
Total resting periods, locomotor time 2	0.9	1.6	4.4	2.1	-1.1	-0.6	-0.7
Rest time, locomotor task time 2	2.1	2.6	6.0	2.4	0.2	0.1	-2.1
Distance moved, locomotor task time 2	1.5	1.8	4.2	-1.5	-0.7	-0.6	2.1
Vertical activity count, locomotor time 2	0.2	0.3	0.8	-0.9	-0.1	0.3	0.7
Light reinforcement 1	0.2	0.4	0.9	-0.7	-0.4	-0.3	1.0
Light reinforcement 2	1.8	2.7	4.6	1.0	-2.0	-2.1	1.2
Bone: marrow area	2.8	6.0	15.5	3.9	-1.9	-2.2	-0.2
Bone: maximum diameter	1.2	2.1	8.5	2.9	-0.3	-0.2	-0.2
Bone: maximum force	1.1	2.0	4.8	-0.0	-2.2	-1.6	0.7
Bone: maximum moment	1.1	1.9	3.9	0.4	-2.0	-1.4	1.2
Mean time between licks in bursts	0.7	1.7	6.8	2.6	0.1	-0.2	-0.4
Mean num. licks in bursts	0.7	1.1	3.2	-1.8	0.4	1.0	0.3
Cd content in liver	0.6	0.7	2.2	-0.7	0.1	0.3	1.5
Co content in liver	0.8	0.9	1.9	-1.4	-0.5	-0.6	1.1
Cu content in liver	1.7	2.0	4.2	-2.1	0.9	1.6	0.6
Fe content in liver	0.8	1.0	1.7	-1.3	-1.0	-1.1	0.1
K content in liver	0.7	0.6	1.0	-0.7	1.0	1.0	-0.3
Mg content in liver	0.8	0.8	1.1	0.8	1.0	0.9	-0.8
Mn content in liver	2.5	2.8	5.3	2.3	1.4	1.1	-1.7
Na content in liver	0.5	0.5	1.7	-1.3	-0.1	0.0	0.5
Rb content in liver	0.4	0.4	1.1	-0.3	0.7	1.0	0.2
Se content in liver	1.2	1.4	5.1	2.3	-0.3	-0.5	-0.6
Sr content in liver	0.6	0.5	0.7	0.6	-0.8	-0.5	-0.8
Zn content in liver	0.3	0.3	0.5	0.7	0.4	0.7	0.5
Bone: minimum diameter	1.4	2.5	9.1	3.0	-0.5	-0.4	-0.8
Time in familiar zone, hab. session 1	2.7	2.6	4.6	-2.1	1.6	1.8	-0.4
Time in novel zone, hab. session 1	3.2	3.2	5.5	2.3	-1.3	-1.4	1.9
Total zone transitions, hab. session 1	0.5	0.7	1.7	-0.1	1.3	1.1	0.2
Total locomotion distance, hab. session 1	0.4	0.5	1.0	-0.5	1.0	1.0	-0.1
Locomotion velocity, hab. session 1	0.4	0.6	0.7	-0.8	0.8	0.8	-0.5
Time in familiar zone, hab. session 2	0.9	1.0	1.3	-1.0	0.7	1.2	-1.0
Time in novel zone, hab. session 2	1.4	1.4	2.8	0.7	-0.8	-1.4	1.7
Total zone transitions, hab. session 2	0.1	0.2	0.5	-0.7	0.5	0.2	-0.1
Total locomotion distance, hab. session 2	0.7	1.0	1.9	-0.8	1.4	1.1	-0.2
Locomotion velocity, hab. session 2	0.9	1.2	2.2	-0.8	1.5	1.4	-0.5
Novel to familiar place preference ratio	0.6	0.7	2.1	-0.4	-0.3	-0.6	1.4
Novelty place preference	0.8	0.9	2.3	-0.2	-0.6	-0.9	1.5
Time in novel zone, NPP test	1.1	1.2	2.9	0.0	-0.8	-1.2	1.7
Total zone transitions, NPP test	0.7	1.0	2.0	0.1	1.4	1.1	0.9
Total locomotion distance, NPP test	0.7	1.0	1.6	-0.8	1.3	1.1	0.7
Locomotion velocity, NPP test	1.2	1.7	3.1	-1.0	1.8	1.6	0.3
Intraocular pressure	0.3	0.4	0.7	0.0	0.8	0.8	0.6
Delta distance traveled before/after self-admin	1.1	1.2	3.0	-0.2	-1.1	-1.7	0.6
Delta ambulatory time before/after self-admin	0.6	0.8	2.2	0.1	-1.0	-1.5	0.0
Parametrial fat weight	0.5	1.2	2.8	0.1	-1.7	-1.4	0.0
Pavlov. Cond. lever latency	1.6	2.0	6.0	-2.5	-0.8	0.1	1.1
Pavlov. Cond. magazine entry latency	2.8	3.6	7.7	1.8	1.4	1.1	-2.8
Pavlov. Cond. change in total contacts	1.3	1.4	3.4	1.9	-0.5	-1.3	-0.5
Pavlov. Cond. index score	2.9	3.7	7.3	2.3	1.2	0.6	-2.7
Pavlov. Cond. latency score	2.5	3.2	6.0	2.4	1.0	0.4	-2.4
Pavlov. Cond. lever contacts	1.7	2.0	5.8	2.4	0.6	-0.1	-1.3
Pavlov. Cond. magazine entry number	3.1	3.9	9.3	-1.4	-1.7	-1.2	3.1
Pavlov. Cond. intertrial magazine entries	1.0	1.2	2.8	-1.7	0.2	0.5	1.3
Pavlov. Cond. lever-magazine prob. diff.	3.0	3.8	7.7	2.2	1.4	0.8	-2.8
Pavlov. Cond. response bias	2.8	3.5	7.2	2.1	1.4	0.6	-2.7
Pavlov. Cond. lever latency	0.5	0.6	1.1	0.3	-0.9	-1.1	-0.7
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	0.6	-0.5	-0.4	-0.1
Pavlov. Cond. change in total contacts	0.2	0.2	0.8	-0.2	-0.3	-0.3	0.9
Pavlov. Cond. index score	0.1	0.1	0.2	0.4	0.1	0.2	0.5
Pavlov. Cond. latency score	0.0	0.0	0.1	0.1	0.0	0.1	0.4
Pavlov. Cond. lever contacts	0.4	0.5	0.8	-0.2	0.7	0.8	0.9
Pavlov. Cond. magazine entry number	0.2	0.3	0.4	-0.3	0.5	0.6	-0.7
Pavlov. Cond. intertrial magazine entries	0.8	1.1	2.0	1.2	0.8	0.7	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.4	0.4	0.2	0.2	0.6
Pavlov. Cond. response bias	0.2	0.3	0.4	0.5	0.6	0.5	0.6
Time in closed arm before self-admin	0.1	0.1	0.3	-0.5	0.1	0.2	-0.3
Time in closed arm after self-admin	1.2	1.3	2.3	-1.5	-1.2	-1.1	0.3
Time in open arm before self-admin	0.4	0.4	0.9	0.5	0.4	0.4	-1.0
Time in open arm after self-admin	0.8	0.9	1.5	1.2	0.7	0.9	-0.9
Bone: periosteal estimation	2.0	4.2	8.4	2.9	-2.1	-1.9	0.5
Bone: periosteal perimeter	1.1	1.9	6.0	2.4	-1.0	-0.8	0.0
Bone: post-yield work	1.4	2.1	7.9	2.8	0.5	0.6	-0.0
Progressive ratio test 1 active lever presses	0.6	0.7	2.2	-1.5	-0.7	-0.3	0.0
Progressive ratio test 1 breakpoint	0.6	0.7	2.1	-1.4	-0.7	-0.4	0.1
Progressive ratio test 1 inactive lever presses	1.1	1.5	3.5	-1.9	0.1	0.4	1.6
Progressive ratio test 2 active lever presses	0.7	0.8	3.2	-1.8	-0.2	0.2	0.0
Progressive ratio test 2 breakpoint	0.8	0.9	3.6	-1.9	-0.2	0.1	-0.0
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.5	-0.3	-0.5	-0.4	0.7
Incentive Sensitization - Responses	0.5	0.7	1.4	-1.2	0.6	0.8	-0.7
Incentive Sensitization - Breakpoint	0.6	0.8	1.5	-1.2	0.6	0.8	-0.7
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.8	0.0	0.4	0.4	-0.9
Progressive ratio	2.2	3.4	6.5	-0.8	-2.5	-2.6	-0.5
Food seeking constrained by brief footshock	0.0	0.0	0.1	0.1	-0.2	0.0	0.3
Seeking ratio, punishment vs. effort	1.7	2.4	4.7	0.6	1.9	2.2	0.8
Retroperitoneal fat weight	0.3	1.3	2.5	0.2	-1.6	-1.6	0.6
Reaction time number correct	0.6	1.1	2.6	-1.6	-0.4	-0.7	1.1
Reaction time mean minus median	1.5	3.7	11.1	3.3	-0.1	0.1	-1.9
Reaction time mean minus median AUC	0.9	2.2	8.2	2.9	0.0	0.1	-0.8
Reaction time num false alarms	0.1	0.1	0.5	0.7	0.0	-0.2	0.1
Reaction time num false alarms AUC	0.1	0.2	0.7	0.9	0.0	-0.3	0.1
Reaction time trials correct on left	0.6	1.1	2.6	-1.6	-0.4	-0.7	1.1
Reaction time trials on left	0.5	1.0	2.3	-1.5	-0.5	-0.7	1.0
Reaction time mean	2.2	3.4	11.6	3.4	0.8	0.7	-1.0
Reaction time mean AUC	2.1	3.3	11.9	3.5	0.6	0.5	-0.8
Median of all reaction times	1.7	2.4	7.6	2.8	0.9	0.8	-0.6
Reaction time omissions	1.7	2.6	6.6	2.6	0.1	-0.1	-1.9
Reaction time false alarm rate	0.6	0.8	3.2	1.8	0.3	0.2	-0.2
Reaction time premature initiation rate	0.5	0.7	1.5	0.0	-1.1	-1.2	0.5
Reaction time premature initiations	0.9	1.6	2.9	-0.9	-1.3	-1.7	1.0
Std. dev. reaction times	2.0	3.7	13.2	3.6	-0.1	-0.0	-1.3
Reaction time trials completed	0.5	1.0	2.3	-1.5	-0.5	-0.7	1.0
Reaction time trials AUC	0.5	1.0	2.4	-1.5	-0.4	-0.7	1.0
Run reversals in cocaine runway, females	0.7	0.7	2.0	-0.6	0.4	0.7	1.4
Run reversals in cocaine runway, males	2.3	2.3	5.8	2.4	-1.1	-1.3	-0.6
Latency to leave start box in cocaine runway	0.0	0.0	0.1	-0.1	0.2	-0.3	0.1
Latency to leave start box in cocaine runway, F	0.4	0.4	1.2	0.3	1.1	0.6	0.2
Latency to leave start box in cocaine runway, M	1.2	1.1	2.3	-0.6	-1.3	-1.5	0.2
Std. dev. time between licks in bursts	1.4	1.9	6.7	2.6	-0.2	-0.3	-0.9
Total sessions with >9 infusions	0.5	0.6	0.9	-1.0	-0.8	-0.7	0.7
Short access day 1 total inactive lever presses	0.8	1.1	1.7	1.2	-1.3	-1.0	-0.2
Short access day 10 total inactive lever presses	0.8	1.9	3.0	0.5	1.6	1.7	-1.4
Short access day 1 total infusions	0.2	0.2	0.7	-0.4	0.0	0.1	0.8
Short access day 10 total infusions	0.5	0.7	1.2	-0.9	-0.5	-0.6	1.1
Short access total infusions	0.8	1.0	2.0	-0.9	-0.8	-0.7	1.4
Short access day 1 locomotion	0.5	0.7	1.4	-0.4	1.2	0.9	0.5
Short access day 10 total locomotion	0.4	0.8	1.5	1.2	-0.9	-0.8	0.5
Short access total locomotion	0.1	0.1	0.2	0.1	-0.4	-0.4	0.5
One hour access (0.3 mA shock)	0.9	1.0	2.4	-0.7	1.1	1.6	-0.1
Compulsive drug intake	3.8	4.6	8.5	0.6	2.3	2.0	-2.9
One hour access (shock baseline)	1.0	1.5	4.4	-0.5	-1.0	-0.5	2.1
Social response proportion	0.2	0.3	0.7	0.8	-0.1	0.3	0.5
Social responses	0.1	0.1	0.4	0.1	-0.7	-0.0	-0.0
Social time	2.3	3.1	7.1	2.2	0.0	0.5	-2.7
Soleus weight	1.5	4.4	17.3	4.2	-0.1	-0.4	-0.4
Bone: stiffness	0.2	0.4	0.6	-0.8	-0.7	-0.2	-0.4
Tibialis anterior weight	0.4	1.3	3.0	-1.5	0.2	-0.0	1.7
Time to tail flick, vehicle, before self-admin	3.2	3.3	11.0	0.3	1.0	1.1	-3.3
Time to tail flick, vehicle, after self-admin	1.1	1.4	4.5	0.4	0.5	0.9	-2.1
Time to tail flick, test, before self-admin	0.1	0.1	0.3	-0.3	-0.3	0.2	-0.6
Time to tail flick, test, after self-admin	1.5	1.5	5.5	0.4	-0.2	0.6	-2.4
Delta time to tail flick, vehicle, before/after SA	0.9	0.8	3.0	-0.5	-0.2	-0.1	1.7
Delta time to tail flick, test, before/after SA	0.5	0.5	0.9	-0.4	0.7	0.8	-1.0
Tibia length	1.7	4.7	7.9	2.8	-2.2	-2.4	-0.7
Ambulatory time before self-admin	0.3	0.4	0.8	0.7	-0.2	0.4	-0.9
Ambulatory time after self-admin	0.9	1.1	2.7	0.8	-0.8	-0.6	-1.7
Bone: tissue strength	0.5	0.5	1.3	-0.1	-1.1	-0.7	0.4
Total heroin consumption	0.3	0.4	1.2	0.5	-0.1	0.4	-1.1
Bone: trabecular number	0.8	1.3	1.6	-1.3	1.2	1.2	0.9
Bone: trabecular spacing	2.0	2.6	5.0	1.1	-2.2	-2.1	0.0
Bone: trabecular thickness	0.9	1.2	2.1	-0.8	1.4	1.4	0.5
Bone: trabecular tissue density	0.8	1.2	2.0	-0.0	-1.2	-1.1	1.4
Water consumed over 24 hours	0.1	0.1	0.1	0.3	-0.2	-0.2	-0.4
Number of responses in last shaping day	0.6	0.7	1.5	0.7	-0.3	-0.8	1.2