Hub : Genes

Rnf213

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose intron excision ratio chr10_104668843_104675520 0.05 0.03 6.6e-06 0.06 0.05 0.04 0.05 7.3e-07 2.9e-06 3.3e-05 1.5e-06
2 Adipose intron excision ratio chr10_104671783_104675520 0.03 0.02 3.9e-04 0.03 0.03 0.02 0.02 2.7e-04 8.0e-04 1.6e-03 1.0e-03
3 Brain mRNA stability Rnf213 0.12 0.06 1.6e-10 0.1 0.1 0.07 0.09 1.5e-09 3.6e-09 9.3e-07 1.0e-08
4 Adipose intron excision ratio chr10_104737305_104737986 0.04 0.03 2.5e-05 0.04 0.05 0.04 0.05 1.0e-05 7.5e-06 5.0e-05 7.2e-06
5 PL mRNA stability Rnf213 0.1 0.05 4.1e-12 0.08 0.12 0.1 0.1 5.1e-09 3.0e-13 1.7e-11 2.1e-11
6 pVTA mRNA stability Rnf213 0.1 0.06 3.0e-04 0.05 0.06 0.04 0.05 2.8e-03 1.5e-03 8.6e-03 2.7e-03
7 Adipose intron excision ratio chr10_104738067_104738653 0.05 0.03 4.4e-06 0.05 0.05 0.05 0.05 1.5e-06 1.3e-06 4.3e-06 2.0e-06
8 BLA mRNA stability Rnf213 0.07 0.05 5.7e-04 0.07 0.06 0.07 0.06 1.0e-04 3.0e-04 1.0e-04 4.3e-04
9 NAcc mRNA stability Rnf213 0.02 0.02 5.1e-03 0.01 0.01 0.01 0.01 1.6e-02 2.5e-02 2.6e-02 4.3e-02
10 PL gene expression Rnf213 0.03 0.03 1.5e-03 0.03 0.02 0 0.02 7.0e-04 3.3e-03 9.3e-02 2.6e-03
11 Adipose isoform ratio XM_039087543.1 0.03 0.02 8.2e-03 0.01 0.01 0.01 0.01 2.6e-02 2.4e-02 3.1e-02 2.6e-02
12 Adipose isoform ratio XM_039087542.1 0.02 0.02 7.9e-03 0.02 0.01 0.01 0.02 1.7e-03 3.2e-02 1.2e-02 5.4e-03
13 Adipose gene expression Rnf213 0.05 0.04 5.9e-04 0.03 0.03 0.02 0.02 4.5e-04 8.3e-04 5.3e-03 1.0e-03
14 Liver gene expression Rnf213 0.19 0.08 0.0e+00 0.18 0.19 0.19 0.19 3.4e-19 5.0e-21 2.0e-20 2.5e-20
15 Liver mRNA stability Rnf213 0.03 0.02 1.3e-03 0.02 0.02 0.01 0.01 1.3e-03 5.0e-03 1.6e-02 1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.10.10.30.2-0.2-0.1-0.20.60.1-0.0-0.4-0.5-0.6-0.3-0.4-0.40.5-0.4
Area under the delay curve1.41.43.2-1.71.70.80.9-1.8-0.9-0.71.01.31.31.00.90.9-1.11.4
BMI with tail1.03.14.61.3-1.3-1.4-1.51.91.81.6-2.0-2.1-2.0-2.1-2.1-2.12.0-0.6
BMI without tail7.014.420.13.5-3.5-3.3-3.44.23.83.5-4.2-4.5-4.1-4.3-4.1-4.14.1-1.3
Body weight3.715.524.04.7-4.7-4.8-4.94.14.84.9-3.7-3.3-2.8-3.9-3.3-3.42.31.7
Weight adjusted by age2.63.05.12.3-2.3-2.1-2.11.92.02.0-1.6-1.3-1.4-1.5-1.3-1.40.81.0
Bone surface0.10.10.20.4-0.4-0.5-0.5-0.00.20.30.30.20.30.20.30.3-0.40.3
Bone volume0.10.10.20.4-0.4-0.5-0.50.40.30.3-0.2-0.3-0.3-0.2-0.2-0.20.3-0.3
Breakpoint value in progressive ratio session0.91.01.60.9-0.9-1.0-1.01.31.00.9-1.1-1.0-1.1-1.1-1.0-1.01.1-0.4
Number of licking bursts0.20.20.40.6-0.6-0.6-0.60.40.60.6-0.4-0.4-0.3-0.5-0.4-0.40.30.4
Context. condit. distance diff. score1.92.34.10.7-0.7-0.7-0.71.21.31.2-1.9-1.9-2.0-1.8-1.9-2.02.0-1.3
Locomotion velocity, session 15.15.58.0-2.12.12.22.1-2.8-2.3-2.02.62.62.52.62.72.6-2.50.6
Locomotion distance, session 11.01.33.0-1.71.71.71.6-1.0-1.4-1.50.70.30.30.70.40.4-0.0-1.4
Locomotion velocity, session 25.15.98.1-2.82.82.62.7-2.5-2.8-2.82.52.32.42.62.22.3-1.9-0.5
Locomotion distance, session 20.20.30.9-0.70.70.70.70.2-0.6-0.9-0.1-0.4-0.4-0.0-0.3-0.20.5-0.9
Locomotion velocity, session 31.92.23.2-1.61.61.61.5-1.8-1.5-1.41.61.71.31.61.61.6-1.4-0.1
Locomotion distance, session 32.72.95.4-2.22.22.32.2-1.9-2.0-2.01.51.21.01.61.41.3-0.9-0.8
Stereotopy head waving bouts, day 30.40.50.9-0.70.70.50.5-0.9-0.6-0.50.70.80.80.80.60.7-0.7-0.1
Stereotopy head waving duration, day 30.10.10.4-0.40.40.30.3-0.6-0.3-0.10.30.50.20.30.20.3-0.2-0.6
Locomotion velocity, session 70.50.61.2-1.01.01.11.1-1.0-0.8-0.70.50.40.10.50.30.4-0.1-0.9
Locomotion distance, session 71.72.19.5-1.91.92.02.1-1.0-1.4-1.50.2-0.4-0.10.3-0.3-0.11.0-3.1
Stereotopy head waving bouts, day 70.50.61.20.6-0.6-0.7-0.80.50.91.0-0.9-0.5-1.1-0.8-0.8-1.00.60.0
Stereotopy head waving duration, day 70.50.71.61.0-1.0-1.0-1.10.41.11.3-0.6-0.2-0.8-0.6-0.4-0.50.01.0
Locomotion velocity, session 80.40.51.4-0.60.60.40.3-0.30.20.4-0.6-0.8-0.8-0.6-0.9-0.80.9-1.2
Locomotion distance, session 82.43.57.50.5-0.5-0.4-0.41.71.10.8-2.3-2.5-2.5-2.1-2.5-2.42.7-2.4
Degree of sensitization distance1.81.93.20.9-0.9-1.0-0.91.51.10.9-1.6-1.7-1.3-1.5-1.7-1.61.8-1.4
Degree of sensitization stereotypy1.11.22.30.9-0.9-1.0-1.11.01.21.3-1.2-0.9-1.5-1.2-1.1-1.31.00.0
Conditioned locomotion5.15.97.82.4-2.4-2.5-2.52.82.62.5-2.6-2.5-2.5-2.6-2.5-2.62.20.0
Cocaine response after cond. corrected0.10.10.2-0.30.30.40.4-0.4-0.3-0.20.30.20.10.20.40.4-0.1-0.0
Cocaine response after cond. not corrected0.70.81.2-0.90.91.11.0-1.1-0.9-0.81.00.80.60.91.11.0-0.6-0.2
Cocaine response before conditioning0.81.01.5-1.11.11.11.1-1.2-1.1-1.01.00.90.81.01.00.9-0.7-0.3
Saline control response1.82.44.52.1-2.1-1.9-2.01.61.92.0-1.3-1.1-1.3-1.3-0.9-1.00.70.8
Bone: connectivity density0.00.10.2-0.30.30.40.30.0-0.2-0.3-0.1-0.2-0.3-0.1-0.2-0.20.3-0.5
Bone: cortical apparent density2.12.84.9-2.12.12.12.1-1.5-2.1-2.21.51.31.11.61.21.2-0.8-1.2
Bone: cortical area4.26.312.03.3-3.3-3.5-3.42.53.03.1-2.0-1.4-1.7-2.0-1.5-1.40.52.4
Bone: cortical porosity0.60.71.70.6-0.6-0.7-0.6-0.30.10.30.81.11.10.71.01.0-1.21.3
Bone: cortical porosity0.40.51.50.8-0.8-0.9-0.90.00.50.70.30.50.60.20.40.5-0.71.2
Bone: cortical thickness3.35.410.73.2-3.2-3.3-3.22.52.62.6-1.7-1.1-1.3-1.7-1.2-1.10.12.9
Bone: cortical thickness1.51.72.91.5-1.5-1.7-1.71.31.51.5-1.1-0.9-0.8-1.1-0.9-1.00.31.7
Bone: cortical tissue density2.53.25.6-2.22.22.32.3-1.6-2.2-2.41.61.41.21.71.31.3-0.9-1.3
Condit. Reinf. active minus inactive responses2.22.53.61.8-1.8-1.7-1.71.91.71.6-1.6-1.5-1.4-1.6-1.5-1.51.10.6
Condit. Reinf. active-inactive response ratio1.51.62.21.2-1.2-1.2-1.21.51.31.1-1.4-1.3-1.3-1.4-1.5-1.41.10.3
Condit. Reinf. active responses3.44.16.42.5-2.5-2.3-2.32.52.22.0-2.0-1.8-1.8-2.0-1.8-1.71.30.7
Condit. Reinf. inactive responses0.70.81.61.3-1.3-1.0-1.11.20.90.8-0.8-0.7-0.8-0.8-0.6-0.60.50.1
Incentive salience index mean1.72.13.21.8-1.8-1.7-1.61.81.61.5-1.4-1.2-1.2-1.4-1.3-1.30.80.8
Condit. Reinf. lever presses0.20.20.30.4-0.4-0.4-0.30.60.40.3-0.6-0.4-0.6-0.5-0.5-0.60.5-0.0
Condit. Reinf. active minus inactive responses1.21.52.41.3-1.3-1.3-1.31.01.51.5-1.2-1.1-1.2-1.2-1.0-1.10.41.6
Condit. Reinf. active-inactive response ratio1.71.83.21.7-1.7-1.8-1.81.31.61.6-1.0-0.8-0.7-1.0-0.7-0.70.11.8
Condit. Reinf. active responses0.81.12.10.6-0.6-0.7-0.71.01.00.9-1.4-1.4-1.4-1.3-1.3-1.31.00.4
Condit. Reinf. inactive responses0.30.41.0-0.80.80.80.7-0.1-0.4-0.5-0.4-0.6-0.6-0.3-0.5-0.50.7-1.0
Condit. Reinf. lever presses1.52.14.00.6-0.6-0.7-0.71.51.10.8-1.8-2.0-2.0-1.7-1.9-1.81.9-1.1
Condit. Reinf. lever reinforcers received1.31.83.70.6-0.6-0.7-0.71.21.21.0-1.8-1.9-1.9-1.7-1.7-1.81.5-0.1
Conditioned reinforcement - actives0.40.40.80.9-0.9-0.4-0.50.80.50.4-0.7-0.7-0.8-0.6-0.3-0.20.6-0.1
Conditioned reinforcement - inactives1.21.42.61.4-1.4-1.6-1.61.31.31.4-1.1-0.9-0.8-1.0-1.1-0.90.6-0.0
Conditioned locomotion0.50.61.51.2-1.2-1.0-1.01.10.70.6-0.4-0.8-0.7-0.5-0.1-0.20.4-0.1
Patch foraging indifference point 0 sec0.61.01.90.7-0.7-0.8-0.81.40.70.4-1.1-1.1-1.0-1.0-1.3-1.21.2-1.2
Patch foraging indifference point AUC0.10.10.20.1-0.1-0.2-0.20.30.20.1-0.2-0.3-0.4-0.3-0.3-0.20.5-0.3
Delay disc. indifference point, 0s delay0.10.21.50.2-0.2-0.2-0.2-0.40.30.5-0.0-0.10.0-0.00.30.2-0.41.2
Delay disc. indifference point, 16s delay0.40.41.9-1.41.40.60.6-0.6-0.6-0.6-0.10.30.1-0.0-0.3-0.50.4-0.5
Delay disc. indifference point, 2s delay0.40.42.6-0.60.6-0.00.0-0.9-0.10.00.40.60.70.40.50.3-0.81.6
Delay disc. indifference point, 24s delay4.84.67.1-2.72.72.02.1-2.5-2.3-2.32.12.32.42.21.81.8-1.80.5
Delay disc. indifference point, 4s delay0.30.31.9-0.70.7-0.1-0.1-0.90.00.20.20.40.60.20.40.3-0.51.4
Delay disc. indifference point, 8s delay2.22.24.7-1.41.41.01.1-2.1-1.0-0.71.51.71.71.41.41.5-1.82.2
Indifference point function ln k0.60.81.6-1.21.21.21.2-0.7-1.1-1.20.50.40.50.60.40.3-0.0-1.3
Indifference point function log k0.60.81.6-1.21.21.21.2-0.7-1.1-1.20.50.40.50.60.40.3-0.0-1.3
Patch foraging total patch changes 0 sec1.01.62.60.7-0.7-0.9-0.81.60.80.5-1.4-1.4-1.3-1.3-1.6-1.51.6-1.6
Patch foraging total patch changes 12 sec0.30.41.10.2-0.2-0.8-0.71.10.30.1-0.6-0.5-0.6-0.5-0.8-0.60.8-0.9
Patch foraging total patch changes 18 sec1.01.33.2-0.10.1-0.4-0.31.10.60.3-1.4-1.4-1.3-1.3-1.6-1.51.8-1.6
Patch foraging total patch changes 24 sec1.92.33.01.4-1.4-1.6-1.51.71.61.5-1.6-1.6-1.6-1.6-1.6-1.51.30.2
Patch foraging total patch changes 6 sec0.40.61.81.0-1.0-1.2-1.21.30.60.4-0.5-0.4-0.4-0.5-0.4-0.30.4-0.1
Patch foraging time to switch 0 sec1.01.62.3-1.31.31.31.2-1.5-1.2-1.11.31.21.51.31.21.2-1.20.4
Patch foraging water rate 0 sec5.38.410.52.7-2.7-3.0-2.93.23.02.8-3.2-3.0-3.2-3.2-3.2-3.22.8-0.7
Patch foraging water rate 12 sec1.72.54.90.8-0.8-0.6-0.51.61.00.7-2.0-1.9-2.0-1.7-2.2-2.12.2-1.8
Patch foraging water rate 18 sec2.94.06.81.7-1.7-1.6-1.52.21.81.6-2.1-2.2-2.6-2.2-2.0-2.12.5-1.5
Patch foraging water rate 24 sec8.011.117.22.4-2.4-2.4-2.53.72.92.6-4.0-3.7-3.9-3.8-4.0-4.04.1-2.5
Patch foraging water rate 6 sec0.71.12.10.8-0.8-0.6-0.61.10.90.8-1.1-1.4-1.4-1.3-0.9-1.11.4-0.8
Seeking ratio, delayed vs. immediate footshock0.60.72.51.2-1.2-1.0-1.00.80.90.9-0.7-0.4-0.4-0.5-0.3-0.2-0.31.6
Distance traveled before self-admin0.70.71.51.0-1.0-1.1-1.00.61.11.2-0.7-0.4-0.5-0.7-0.5-0.60.11.1
Distance traveled after self-admin1.51.63.01.1-1.1-0.8-0.81.51.00.8-1.4-1.4-1.7-1.4-1.2-1.31.7-1.5
Extensor digitorum longus weight0.72.66.00.3-0.3-0.5-0.41.70.80.5-1.8-2.2-2.1-1.8-2.1-2.02.4-2.4
Bone: elastic displacement1.31.52.91.5-1.5-1.5-1.51.71.21.0-1.1-0.9-1.4-1.1-1.0-1.00.60.5
Bone: elastic work3.84.910.43.1-3.1-3.2-3.22.62.52.4-1.5-1.0-1.5-1.6-1.1-1.10.32.0
Bone: endosteal estimation0.20.31.4-0.00.0-0.1-0.10.20.30.3-0.5-0.8-0.6-0.6-0.7-0.70.9-1.2
Bone: endosteal perimeter0.30.61.41.1-1.1-1.2-1.20.30.91.2-0.1-0.00.1-0.30.00.0-0.20.9
Epididymis fat weight1.84.24.92.0-2.0-2.1-2.12.22.22.2-2.2-2.2-1.9-2.2-2.2-2.21.9-0.3
Delta time in closed arm before/after self-admin0.30.21.90.2-0.2-0.4-0.4-0.10.20.30.40.10.30.20.50.5-0.61.4
Delta time in open arm before/after self-admin0.80.81.40.5-0.5-0.7-0.71.00.70.6-1.2-0.9-1.0-1.1-1.1-1.11.2-0.7
Diff in mean of infusions in LGA sessions0.00.00.1-0.20.2-0.2-0.10.10.10.1-0.3-0.00.0-0.1-0.3-0.30.10.0
Delay discount exponential model param2.02.14.32.0-2.0-1.1-1.12.11.21.0-1.3-1.6-1.6-1.2-1.1-1.11.3-1.4
Extinction: sum of active levers before priming0.70.71.2-1.11.11.11.0-0.8-1.0-1.00.80.40.20.60.60.7-0.1-0.9
Active lever presses in extinction session 60.50.40.90.4-0.4-0.7-0.70.70.70.6-0.8-0.4-0.6-0.8-0.8-1.00.60.1
Bone: final force3.96.310.63.3-3.3-3.2-3.22.63.03.1-2.2-1.8-1.8-2.3-1.8-1.81.02.0
Bone: final moment4.57.312.33.5-3.5-3.5-3.52.93.23.3-2.4-1.9-1.9-2.4-1.9-1.91.11.9
Food consumed during 24 hour testing period1.62.02.91.3-1.3-1.2-1.21.41.51.5-1.5-1.6-1.7-1.6-1.5-1.61.4-0.5
Glucose4.26.38.3-2.52.52.42.4-2.6-2.8-2.82.72.92.52.82.72.7-2.2-0.2
Heart weight0.40.60.90.8-0.8-0.9-0.91.00.70.7-0.7-0.5-0.7-0.7-0.7-0.70.6-0.6
Delay discount hyperbolic model param1.71.83.91.9-1.9-0.9-1.02.01.10.8-1.2-1.4-1.5-1.1-1.1-1.01.2-1.5
Intermittent access intake day 1-15 change0.10.10.30.3-0.3-0.3-0.30.10.40.5-0.4-0.1-0.2-0.3-0.4-0.30.10.2
Intermittent access intake escalation0.20.20.40.5-0.5-0.5-0.50.30.60.6-0.6-0.3-0.4-0.5-0.6-0.50.30.1
Intermittent access intake escalation 20.20.20.60.7-0.7-0.5-0.60.40.70.8-0.4-0.0-0.1-0.3-0.2-0.2-0.10.7
Intermitt. access day 1 inactive lever presses1.61.73.31.6-1.6-1.8-1.81.31.61.7-1.1-1.1-1.0-1.2-1.0-1.00.70.4
Intermitt. access day 15 inactive lever presses2.32.53.11.7-1.7-1.6-1.51.81.61.6-1.7-1.6-1.7-1.7-1.5-1.61.5-0.3
Intermitt. access escalation Index1.71.52.11.4-1.4-1.4-1.41.31.41.4-1.2-0.9-1.1-1.2-1.2-1.20.80.6
Intermittent access day 1 total infusions0.20.30.60.7-0.7-0.6-0.60.70.40.3-0.4-0.5-0.5-0.4-0.1-0.30.4-0.4
Intermittent access day 15 total infusions0.60.71.21.0-1.0-1.1-1.00.90.90.9-0.8-0.6-0.7-0.7-0.7-0.70.5-0.0
Intermittent access terminal intake (last 3 days)0.70.71.61.3-1.3-1.1-1.11.01.01.0-0.8-0.5-0.7-0.7-0.4-0.50.30.3
Intermittent access total infusions0.50.61.11.1-1.1-1.0-1.00.90.80.7-0.7-0.7-0.8-0.7-0.4-0.50.5-0.2
Intermittent access day 1 locomotion0.70.81.51.0-1.0-1.2-1.21.20.80.7-0.8-0.8-0.8-0.8-0.7-0.70.7-0.4
Intermittent access day 15 total locomotion0.20.20.60.8-0.8-0.8-0.80.60.50.6-0.3-0.2-0.2-0.2-0.1-0.1-0.00.2
Intermittent access total locomotion0.70.81.51.1-1.1-1.2-1.21.20.90.8-0.8-0.7-0.7-0.8-0.7-0.60.7-0.3
Intermittent access standard deviation0.40.41.1-0.50.50.30.4-1.0-0.3-0.10.60.70.60.60.60.6-0.81.0
Left kidney weight0.30.94.90.5-0.5-0.6-0.7-0.50.50.90.51.01.00.40.70.8-1.42.2
Right kidney weight0.20.63.20.5-0.5-0.9-0.9-0.10.70.90.10.70.70.00.30.2-0.81.8
Cocaine induced anxiety3.64.17.52.4-2.4-2.7-2.72.02.52.6-1.7-1.6-1.3-1.8-1.4-1.50.72.0
Post-drug Anxiety1.41.52.70.7-0.7-1.7-1.61.11.41.5-1.4-0.9-0.6-1.4-1.6-1.51.10.4
Baseline Anxiety4.75.09.6-3.13.12.82.8-2.5-2.6-2.61.82.01.81.91.31.4-0.9-1.6
Tail length5.215.824.24.9-4.9-4.9-4.94.44.64.7-3.7-3.4-3.1-3.9-3.2-3.22.51.3
Length with tail2.17.515.63.8-3.8-3.9-3.92.43.43.8-1.8-1.2-0.9-2.0-1.3-1.40.22.9
Length without tail1.02.17.1-0.20.2-0.1-0.1-1.4-0.30.11.42.12.01.51.51.5-2.42.7
Times rat made contact with spout0.80.92.11.5-1.5-1.3-1.31.31.00.9-0.5-0.5-1.0-0.7-0.3-0.40.30.4
Lifetime Intake0.10.10.40.6-0.6-0.5-0.50.40.30.3-0.2-0.3-0.4-0.20.0-0.10.2-0.1
Liver weight, left0.50.81.6-0.30.30.30.3-1.1-0.4-0.11.01.10.91.01.21.2-1.31.1
Liver weight, right1.52.57.82.2-2.2-2.1-2.21.31.82.0-0.8-0.3-0.2-0.8-0.3-0.4-0.62.8
Locomotor activity0.30.40.9-0.70.70.90.9-0.8-0.7-0.70.50.30.30.50.60.6-0.1-0.6
Locomotor testing distance0.10.20.6-0.50.50.70.7-0.4-0.4-0.40.1-0.2-0.20.10.10.00.3-0.8
Locomotor testing rearing0.71.22.30.4-0.4-0.3-0.30.90.70.5-1.4-1.4-1.3-1.2-1.5-1.41.5-1.2
Locomotion in novel chamber0.20.20.60.1-0.1-0.5-0.50.50.40.3-0.4-0.7-0.4-0.6-0.5-0.60.8-0.7
Locomotion in novel chamber post-restriction0.30.40.91.0-1.0-0.9-0.80.80.60.6-0.3-0.2-0.3-0.3-0.3-0.30.2-0.3
Fecal boli incidents, locomotor time 10.30.41.2-0.40.41.01.0-0.4-1.0-1.10.40.30.30.60.20.3-0.2-0.3
Change in fecal boli incidents, locomotor task3.83.65.8-2.42.41.91.9-2.0-2.1-2.11.81.82.01.91.81.7-1.2-0.9
Time >=10cm from walls, locomotor time 10.50.51.30.0-0.0-0.1-0.00.30.40.4-0.8-1.0-1.1-0.8-0.9-0.91.1-0.9
Bouts of movement, locomotor time 11.82.03.1-1.71.71.51.6-1.4-1.7-1.71.61.01.21.41.31.3-0.7-0.5
Total resting periods, locomotor time 12.62.94.3-1.91.91.71.8-1.6-2.0-2.12.01.41.51.71.71.7-1.0-0.7
Rest time, locomotor task time 10.70.81.7-0.50.50.50.6-0.7-0.9-0.91.20.91.01.11.31.3-0.90.1
Distance moved, locomotor task time 11.01.12.00.8-0.8-1.0-1.11.11.21.2-1.4-0.7-0.9-1.1-1.4-1.40.80.2
Vertical activity count, locomotor time 11.81.93.41.1-1.1-1.0-1.01.41.31.2-1.6-1.6-1.9-1.5-1.6-1.71.4-0.3
Time >=10cm from walls, locomotor time 20.10.10.20.0-0.0-0.5-0.40.20.10.1-0.30.10.3-0.0-0.3-0.20.00.3
Bouts of movement, locomotor time 21.01.11.6-1.31.31.21.2-1.2-1.2-1.21.10.70.80.90.90.8-0.5-0.2
Total resting periods, locomotor time 20.50.60.9-0.90.90.80.9-0.9-0.9-0.90.90.40.50.70.70.6-0.3-0.2
Rest time, locomotor task time 20.30.30.8-0.40.40.30.3-0.5-0.5-0.50.90.60.60.60.80.8-0.4-0.1
Distance moved, locomotor task time 20.30.31.00.5-0.5-0.8-0.80.40.70.7-0.8-0.1-0.0-0.4-0.6-0.5-0.11.0
Vertical activity count, locomotor time 20.70.71.30.7-0.7-0.6-0.60.70.80.8-1.1-1.0-0.8-0.9-1.1-1.10.70.2
Light reinforcement 12.44.36.92.1-2.1-1.8-1.92.62.01.7-2.3-2.5-2.6-2.3-2.0-2.02.1-0.5
Light reinforcement 22.12.84.72.2-2.2-1.8-1.81.91.91.9-1.6-1.5-1.8-1.6-1.3-1.10.90.9
Bone: marrow area0.20.31.3-0.00.0-0.0-0.00.20.30.4-0.6-0.8-0.6-0.6-0.7-0.70.9-1.1
Bone: maximum diameter1.11.94.41.9-1.9-2.0-2.00.91.82.1-0.8-0.5-0.4-0.9-0.5-0.4-0.11.8
Bone: maximum force3.76.310.83.3-3.3-3.3-3.32.73.03.0-2.2-1.8-1.7-2.2-1.8-1.81.01.7
Bone: maximum moment4.27.212.63.5-3.5-3.5-3.63.03.23.2-2.3-1.9-1.9-2.4-1.9-1.91.21.6
Mean time between licks in bursts0.91.32.4-1.51.51.41.4-1.3-1.3-1.31.01.01.01.10.60.8-0.6-0.7
Mean num. licks in bursts0.10.20.60.5-0.5-0.4-0.40.70.20.1-0.3-0.3-0.7-0.3-0.2-0.20.3-0.4
Cd content in liver0.60.72.0-1.31.31.31.1-0.4-0.7-0.8-0.1-0.2-0.3-0.0-0.5-0.40.6-1.4
Co content in liver0.20.21.1-0.10.10.10.10.5-0.0-0.2-0.4-0.7-0.6-0.4-0.5-0.50.8-1.0
Cu content in liver0.10.20.50.3-0.3-0.4-0.3-0.0-0.1-0.00.30.60.40.40.40.5-0.70.7
Fe content in liver0.40.51.8-1.01.00.90.9-0.6-0.7-0.70.40.30.30.40.30.20.3-1.3
K content in liver2.02.03.01.7-1.7-1.7-1.51.61.51.5-1.3-1.3-1.5-1.3-1.2-1.10.90.2
Mg content in liver0.70.71.40.5-0.5-0.4-0.31.00.50.3-0.9-1.2-1.2-0.8-1.1-1.01.1-1.1
Mn content in liver0.10.10.40.5-0.5-0.3-0.3-0.10.40.6-0.00.10.00.00.10.3-0.40.6
Na content in liver0.20.20.70.2-0.2-0.00.1-0.4-0.1-0.00.50.40.20.40.70.7-0.70.9
Rb content in liver1.92.43.81.2-1.2-1.3-1.31.81.41.2-1.9-1.7-1.8-1.7-1.9-1.81.7-0.5
Se content in liver0.40.50.90.5-0.5-0.7-0.60.70.80.8-0.9-0.9-0.8-0.8-0.8-0.80.9-0.4
Sr content in liver1.31.22.6-0.30.30.30.3-0.9-0.9-0.91.41.41.61.31.41.4-1.50.8
Zn content in liver0.80.92.1-0.00.00.10.2-0.7-0.6-0.51.11.11.21.11.31.3-1.41.2
Bone: minimum diameter2.64.88.62.8-2.8-2.9-2.92.32.62.7-1.9-1.6-1.6-1.9-1.5-1.51.01.1
Time in familiar zone, hab. session 10.10.10.5-0.30.30.20.10.1-0.2-0.3-0.0-0.0-0.2-0.0-0.0-0.10.4-0.7
Time in novel zone, hab. session 10.00.00.20.1-0.1-0.1-0.1-0.20.30.5-0.0-0.2-0.2-0.20.10.1-0.10.4
Total zone transitions, hab. session 10.20.31.6-0.60.60.50.40.2-0.3-0.4-0.4-0.6-0.4-0.3-0.6-0.60.8-1.3
Total locomotion distance, hab. session 11.21.83.70.7-0.7-0.8-0.81.41.10.9-1.5-1.9-1.7-1.6-1.5-1.51.8-1.2
Locomotion velocity, hab. session 11.21.73.20.7-0.7-0.8-0.81.51.00.8-1.6-1.8-1.5-1.4-1.7-1.71.7-1.1
Time in familiar zone, hab. session 20.20.21.1-0.40.40.30.4-0.0-0.2-0.2-0.3-0.3-0.4-0.2-0.3-0.40.7-1.0
Time in novel zone, hab. session 20.10.10.3-0.30.30.30.3-0.4-0.3-0.20.40.40.30.40.30.4-0.50.4
Total zone transitions, hab. session 20.81.13.9-0.30.30.30.20.90.0-0.3-1.1-1.3-1.2-0.9-1.3-1.21.6-2.0
Total locomotion distance, hab. session 21.82.34.20.9-0.9-0.8-0.91.91.00.6-1.9-2.0-2.0-1.6-1.9-1.81.9-1.4
Locomotion velocity, hab. session 21.92.54.61.2-1.2-1.0-1.12.11.20.8-1.9-2.2-2.0-1.7-1.9-1.81.9-1.0
Novel to familiar place preference ratio1.92.04.31.5-1.5-1.6-1.62.11.31.0-1.5-1.3-1.5-1.4-1.5-1.41.00.3
Novelty place preference1.71.73.71.5-1.5-1.5-1.51.91.21.0-1.4-1.2-1.3-1.2-1.3-1.20.90.4
Time in novel zone, NPP test1.71.73.71.3-1.3-1.4-1.41.91.20.9-1.5-1.3-1.4-1.3-1.4-1.31.10.2
Total zone transitions, NPP test0.60.83.2-0.50.50.40.40.6-0.0-0.3-0.9-1.1-0.9-0.8-1.2-1.11.4-1.8
Total locomotion distance, NPP test1.82.44.90.5-0.5-0.5-0.51.90.80.4-1.9-2.1-2.0-1.7-2.1-2.02.2-1.8
Locomotion velocity, NPP test1.52.24.00.7-0.7-0.7-0.71.80.90.5-1.8-2.0-1.8-1.6-1.9-1.82.0-1.5
Intraocular pressure0.71.01.70.5-0.5-0.9-1.01.30.80.5-1.1-1.0-1.1-1.1-1.2-1.11.2-0.9
Delta distance traveled before/after self-admin0.80.83.50.1-0.10.00.00.90.2-0.1-0.8-1.1-1.3-0.9-0.8-0.81.6-1.9
Delta ambulatory time before/after self-admin0.50.64.1-0.40.40.60.60.3-0.4-0.7-0.3-0.5-0.7-0.3-0.3-0.31.2-2.0
Parametrial fat weight1.22.34.72.0-2.0-2.2-2.11.71.71.7-1.2-1.1-1.0-1.3-1.0-1.00.80.6
Pavlov. Cond. lever latency1.31.66.4-1.01.01.11.00.0-0.1-0.2-0.9-1.5-1.5-0.9-1.2-1.31.9-2.5
Pavlov. Cond. magazine entry latency1.21.64.21.9-1.9-2.0-1.90.81.31.5-0.4-0.00.1-0.4-0.0-0.0-0.62.1
Pavlov. Cond. change in total contacts0.10.20.50.4-0.4-0.5-0.40.3-0.0-0.10.20.40.40.30.30.3-0.50.7
Pavlov. Cond. index score1.92.36.22.2-2.2-2.4-2.31.21.61.7-0.60.00.1-0.6-0.2-0.2-0.72.5
Pavlov. Cond. latency score1.51.97.01.9-1.9-2.0-1.90.71.21.3-0.10.60.6-0.00.30.4-1.22.7
Pavlov. Cond. lever contacts0.70.83.31.1-1.1-1.1-1.10.50.40.40.30.80.70.30.50.6-1.11.8
Pavlov. Cond. magazine entry number1.01.23.9-1.51.51.71.6-0.4-1.0-1.2-0.0-0.5-0.6-0.0-0.3-0.40.9-2.0
Pavlov. Cond. intertrial magazine entries0.50.61.30.3-0.3-0.1-0.21.00.30.1-0.9-1.0-1.1-0.8-1.0-1.01.1-1.0
Pavlov. Cond. lever-magazine prob. diff.2.02.56.12.3-2.3-2.5-2.41.41.71.8-0.8-0.2-0.2-0.8-0.4-0.4-0.42.3
Pavlov. Cond. response bias1.11.34.31.6-1.6-1.7-1.70.71.01.1-0.00.40.5-0.00.30.3-0.92.1
Pavlov. Cond. lever latency2.43.35.7-1.21.21.21.2-2.0-1.5-1.22.22.32.42.02.22.1-2.31.2
Pavlov. Cond. magazine entry latency1.01.25.9-1.01.00.80.90.1-0.4-0.6-0.6-1.1-1.1-0.6-1.0-1.01.7-2.4
Pavlov. Cond. change in total contacts0.91.33.3-0.20.20.10.10.90.30.0-1.3-1.6-1.6-1.2-1.4-1.51.8-1.7
Pavlov. Cond. index score1.51.94.70.1-0.1-0.3-0.21.20.60.4-1.6-1.9-1.9-1.5-1.8-1.82.2-1.9
Pavlov. Cond. latency score1.62.04.80.2-0.2-0.4-0.31.20.70.5-1.6-2.0-1.9-1.6-1.8-1.82.2-1.8
Pavlov. Cond. lever contacts3.04.17.01.4-1.4-1.5-1.52.21.71.5-2.4-2.5-2.6-2.3-2.4-2.42.4-1.1
Pavlov. Cond. magazine entry number1.21.56.00.8-0.8-0.6-0.7-0.50.10.41.01.41.71.01.31.3-1.92.4
Pavlov. Cond. intertrial magazine entries1.21.62.61.6-1.6-1.5-1.61.21.51.6-1.2-0.9-1.0-1.1-1.0-0.90.40.9
Pavlov. Cond. lever-magazine prob. diff.1.41.84.7-0.10.1-0.1-0.01.10.50.2-1.5-1.8-1.9-1.4-1.7-1.72.2-2.1
Pavlov. Cond. response bias1.72.35.00.5-0.5-0.6-0.61.51.00.7-1.8-2.1-2.2-1.7-1.9-1.92.2-1.5
Time in closed arm before self-admin0.91.01.8-1.21.20.90.8-1.1-1.1-1.01.01.31.21.00.70.8-0.8-0.3
Time in closed arm after self-admin2.52.65.1-1.61.60.90.9-1.8-1.3-1.22.02.02.21.71.71.7-1.70.9
Time in open arm before self-admin0.10.10.50.2-0.20.40.3-0.3-0.1-0.00.10.20.00.30.20.3-0.60.7
Time in open arm after self-admin0.20.20.50.2-0.2-0.1-0.00.40.20.1-0.6-0.5-0.7-0.5-0.6-0.50.6-0.6
Bone: periosteal estimation1.53.15.32.2-2.2-2.3-2.31.72.12.2-1.6-1.4-1.4-1.6-1.3-1.30.90.8
Bone: periosteal perimeter1.52.56.92.3-2.3-2.4-2.40.91.72.0-0.30.20.0-0.50.10.2-0.92.6
Bone: post-yield work0.10.10.40.0-0.0-0.1-0.10.50.0-0.1-0.3-0.5-0.3-0.3-0.4-0.40.5-0.6
Progressive ratio test 1 active lever presses0.80.81.51.2-1.2-0.9-0.91.10.90.8-0.7-0.9-1.0-0.8-0.7-0.70.6-0.1
Progressive ratio test 1 breakpoint0.90.91.71.3-1.3-1.0-1.01.20.90.8-0.8-1.0-1.1-0.8-0.7-0.80.7-0.3
Progressive ratio test 1 inactive lever presses3.63.95.22.3-2.3-2.3-2.22.12.22.2-2.1-1.9-1.9-2.0-2.0-1.81.30.5
Progressive ratio test 2 active lever presses0.30.30.70.8-0.8-0.8-0.80.70.60.6-0.4-0.3-0.5-0.4-0.2-0.30.3-0.1
Progressive ratio test 2 breakpoint0.40.50.80.9-0.9-0.9-0.90.90.70.7-0.6-0.5-0.6-0.6-0.4-0.50.5-0.3
Progressive ratio test 2 inactive lever presses0.40.51.10.9-0.9-1.0-1.00.70.80.9-0.6-0.2-0.5-0.5-0.4-0.40.2-0.0
Incentive Sensitization - Responses0.00.00.10.2-0.2-0.1-0.1-0.10.10.10.30.20.10.10.40.3-0.2-0.0
Incentive Sensitization - Breakpoint0.00.00.20.2-0.2-0.1-0.1-0.10.10.10.30.30.10.10.40.4-0.30.0
Sum of active levers in priming session hrs 5-60.60.61.40.7-0.7-0.4-0.50.90.70.6-0.8-0.8-1.2-0.9-0.7-0.80.9-0.4
Progressive ratio0.30.30.7-0.70.70.60.7-0.4-0.8-0.90.50.20.40.50.60.5-0.1-0.3
Food seeking constrained by brief footshock0.10.10.2-0.40.40.40.4-0.4-0.2-0.20.20.00.10.10.10.1-0.10.2
Seeking ratio, punishment vs. effort0.20.20.50.4-0.4-0.3-0.30.20.60.7-0.4-0.4-0.5-0.5-0.5-0.50.30.1
Retroperitoneal fat weight5.618.624.54.9-4.9-4.8-4.94.74.94.9-4.4-4.1-3.7-4.4-4.1-4.03.20.8
Reaction time number correct3.85.513.01.0-1.0-0.9-0.92.21.51.2-2.6-3.1-2.8-2.7-2.8-2.93.6-3.1
Reaction time mean minus median0.60.81.5-0.50.50.60.6-0.9-0.7-0.61.01.21.01.01.01.0-1.21.0
Reaction time mean minus median AUC0.20.32.40.3-0.3-0.3-0.3-0.30.20.30.30.50.60.30.40.4-0.81.6
Reaction time num false alarms0.20.30.7-0.80.80.50.5-0.4-0.6-0.70.40.40.80.40.30.3-0.2-0.5
Reaction time num false alarms AUC0.40.61.2-1.11.10.80.7-0.7-0.9-0.90.60.51.00.60.40.3-0.2-0.8
Reaction time trials correct on left3.85.513.01.0-1.0-0.9-0.92.21.51.2-2.6-3.1-2.8-2.7-2.8-2.93.6-3.1
Reaction time trials on left4.05.713.41.0-1.0-0.9-0.92.21.61.3-2.7-3.2-2.9-2.7-2.8-2.93.7-3.1
Reaction time mean0.20.30.60.4-0.4-0.3-0.30.50.60.6-0.7-0.8-0.6-0.7-0.7-0.70.70.2
Reaction time mean AUC0.40.50.90.5-0.5-0.3-0.30.70.70.6-0.9-0.9-0.9-0.9-0.9-0.90.90.0
Median of all reaction times0.50.71.50.5-0.5-0.4-0.40.70.80.8-1.0-1.2-0.9-1.0-1.0-1.11.1-0.1
Reaction time omissions0.30.50.80.7-0.7-0.5-0.50.40.80.9-0.8-0.6-0.7-0.7-0.8-0.70.40.8
Reaction time false alarm rate2.02.85.2-1.51.51.21.2-1.8-1.6-1.51.92.02.31.91.81.8-2.00.7
Reaction time premature initiation rate1.01.32.9-1.61.61.41.4-0.8-1.5-1.70.80.90.91.00.30.5-0.3-1.3
Reaction time premature initiations1.01.48.2-0.90.90.70.70.5-0.5-0.8-0.9-1.0-0.8-0.7-1.4-1.21.8-2.9
Std. dev. reaction times0.20.30.8-0.80.80.90.8-0.6-0.6-0.60.30.30.40.40.10.1-0.1-0.1
Reaction time trials completed4.05.713.41.0-1.0-0.9-0.92.21.61.3-2.7-3.2-2.9-2.7-2.8-2.93.7-3.1
Reaction time trials AUC4.16.013.91.0-1.0-1.0-0.92.31.61.3-2.8-3.3-2.9-2.8-2.9-3.03.7-3.1
Run reversals in cocaine runway, females0.40.41.6-0.90.90.50.5-0.2-0.3-0.4-0.3-0.4-0.2-0.3-0.4-0.50.9-1.3
Run reversals in cocaine runway, males0.20.20.60.7-0.7-0.4-0.40.20.10.20.30.20.30.30.60.8-0.50.5
Latency to leave start box in cocaine runway0.60.71.5-0.80.81.21.2-0.6-1.0-1.10.80.50.20.70.80.8-0.1-1.0
Latency to leave start box in cocaine runway, F0.20.21.5-0.40.40.40.40.1-0.3-0.4-0.0-0.1-0.3-0.1-0.0-0.00.6-1.2
Latency to leave start box in cocaine runway, M0.50.50.9-0.30.30.90.8-0.3-0.8-1.00.90.40.30.81.01.0-0.5-0.5
Std. dev. time between licks in bursts2.12.54.70.9-0.9-1.0-1.01.61.41.2-1.8-1.9-2.2-1.9-1.9-2.02.0-1.1
Total sessions with >9 infusions0.40.50.9-0.60.60.80.8-1.0-0.8-0.70.80.50.50.80.80.8-0.70.2
Short access day 1 total inactive lever presses0.10.20.40.6-0.6-0.6-0.50.30.40.5-0.3-0.3-0.3-0.2-0.2-0.1-0.10.3
Short access day 10 total inactive lever presses3.13.45.42.1-2.1-2.2-2.31.92.32.3-1.8-1.4-1.4-1.8-1.6-1.61.00.8
Short access day 1 total infusions1.01.01.5-1.21.21.01.1-1.2-1.1-1.11.10.90.91.01.00.9-0.7-0.2
Short access day 10 total infusions0.30.41.11.0-1.0-0.8-0.80.70.60.6-0.3-0.5-0.6-0.4-0.1-0.10.10.2
Short access total infusions0.00.00.10.0-0.00.10.1-0.1-0.2-0.20.30.0-0.00.20.40.3-0.1-0.1
Short access day 1 locomotion0.80.91.9-0.60.60.40.5-1.0-0.8-0.71.31.01.01.11.41.3-1.10.6
Short access day 10 total locomotion0.50.61.2-0.50.50.50.3-0.8-0.6-0.50.91.00.90.90.91.1-1.00.5
Short access total locomotion1.41.42.7-0.80.80.80.8-1.3-1.1-1.01.51.31.31.41.61.6-1.40.6
One hour access (0.3 mA shock)1.51.82.71.5-1.5-1.3-1.41.61.31.2-1.4-1.3-1.5-1.4-1.2-1.21.4-0.6
Compulsive drug intake1.11.11.60.8-0.8-1.2-1.11.31.11.0-1.1-0.8-1.0-1.2-1.2-1.11.2-0.3
One hour access (shock baseline)0.10.20.60.8-0.8-0.3-0.40.40.30.3-0.1-0.3-0.4-0.10.20.2-0.00.1
Social response proportion0.10.10.5-0.40.4-0.1-0.00.10.10.0-0.5-0.3-0.2-0.4-0.7-0.70.5-0.3
Social responses0.30.41.00.2-0.2-0.6-0.60.50.60.6-0.9-0.8-0.4-0.8-0.9-1.00.70.1
Social time0.10.20.4-0.10.1-0.2-0.10.30.1-0.0-0.4-0.6-0.6-0.5-0.5-0.60.6-0.1
Soleus weight1.02.96.02.4-2.4-2.4-2.42.31.81.6-1.2-1.1-0.9-1.3-0.8-0.90.61.2
Bone: stiffness0.30.51.20.9-0.9-0.8-0.80.40.91.0-0.5-0.3-0.2-0.5-0.2-0.2-0.11.1
Tibialis anterior weight0.00.10.7-0.20.20.10.10.2-0.2-0.4-0.0-0.3-0.0-0.0-0.1-0.00.3-0.8
Time to tail flick, vehicle, before self-admin0.10.10.10.4-0.4-0.3-0.40.40.20.10.1-0.0-0.2-0.10.20.10.00.0
Time to tail flick, vehicle, after self-admin2.12.22.9-1.61.61.51.4-1.7-1.6-1.61.51.61.71.71.21.2-1.4-0.1
Time to tail flick, test, before self-admin0.10.10.1-0.30.30.10.1-0.2-0.2-0.10.10.40.40.3-0.20.1-0.30.1
Time to tail flick, test, after self-admin0.10.10.8-0.20.2-0.2-0.3-0.20.30.4-0.0-0.10.0-0.2-0.0-0.0-0.00.9
Delta time to tail flick, vehicle, before/after SA0.10.10.5-0.20.20.10.10.2-0.1-0.1-0.5-0.3-0.1-0.2-0.6-0.60.5-0.7
Delta time to tail flick, test, before/after SA0.20.20.5-0.50.50.40.4-0.7-0.3-0.20.40.10.30.20.50.4-0.20.5
Tibia length5.114.531.85.3-5.3-5.1-5.32.44.85.4-2.2-1.2-1.0-2.5-1.3-1.3-0.65.6
Ambulatory time before self-admin1.81.93.61.6-1.6-1.7-1.71.11.81.9-1.3-0.9-1.0-1.3-1.0-1.20.51.4
Ambulatory time after self-admin1.41.52.61.1-1.1-0.9-0.91.41.11.0-1.4-1.3-1.6-1.5-1.2-1.31.5-0.8
Bone: tissue strength2.62.54.41.6-1.6-1.6-1.62.11.51.3-1.7-1.6-1.8-1.7-1.7-1.61.5-0.4
Total heroin consumption0.20.21.40.3-0.3-0.1-0.10.00.40.5-0.3-0.2-0.5-0.3-0.3-0.3-0.21.2
Bone: trabecular number0.10.20.2-0.30.30.40.4-0.3-0.4-0.50.40.40.40.40.40.4-0.40.2
Bone: trabecular spacing3.54.58.01.0-1.0-1.2-1.21.72.01.9-2.7-2.7-2.6-2.6-2.8-2.82.7-1.1
Bone: trabecular thickness0.60.81.80.2-0.20.0-0.0-0.2-0.6-0.71.01.20.91.01.21.2-1.31.1
Bone: trabecular tissue density0.71.01.8-1.11.11.01.0-1.3-1.0-0.81.01.01.21.10.91.0-1.0-0.0
Water consumed over 24 hours0.10.10.50.1-0.10.00.0-0.1-0.2-0.20.50.50.00.40.70.6-0.60.2
Number of responses in last shaping day0.80.92.41.5-1.5-1.1-1.00.71.01.2-0.3-0.3-0.7-0.4-0.10.1-0.31.5