Rnf180

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	intron excision ratio	chr2_38204295_38223689	0.02	0.02	8.7e-03	0.02	0.02	0.02	0.02	8.8e-03	5.1e-03	1.3e-02	1.4e-02
2	Brain	gene expression	Rnf180	0.11	0.07	5.5e-09	0.1	0.1	0.09	0.1	4.9e-10	3.5e-09	4.5e-09	2.2e-09
3	PL	gene expression	Rnf180	0.06	0.04	3.3e-06	0.05	0.06	0.05	0.05	4.4e-06	2.6e-07	5.9e-06	4.1e-06
4	NAcc	gene expression	Rnf180	0.08	0.08	4.4e-05	0.03	0.02	0.02	0.03	1.4e-05	3.3e-04	1.2e-04	5.3e-05
5	IL	isoform ratio	XM_039103134.2	0.53	0.23	4.9e-03	0.05	-0	0.06	0.04	2.5e-02	3.8e-01	1.8e-02	3.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.0	1.8	2.7	-1.4	1.2	-1.3	1.6	-1.2
Area under the delay curve	0.5	0.8	2.5	-0.4	0.4	-0.6	0.9	1.6
BMI with tail	3.2	11.1	13.4	-3.4	3.2	-3.3	3.7	-2.9
BMI without tail	0.8	4.1	5.5	-2.1	2.1	-2.3	2.4	-0.9
Body weight	0.7	2.9	10.4	1.5	-0.8	0.6	-0.8	3.2
Weight adjusted by age	0.0	0.1	0.2	-0.2	0.2	-0.3	0.5	0.5
Bone surface	0.0	0.1	0.1	0.2	-0.3	0.2	0.1	-0.2
Bone volume	0.1	0.2	0.8	-0.1	-0.1	-0.0	0.4	-0.9
Breakpoint value in progressive ratio session	2.7	4.8	5.7	-2.4	2.4	-2.3	2.1	-1.7
Number of licking bursts	0.4	1.1	1.7	-1.2	0.9	-0.8	0.9	-1.3
Context. condit. distance diff. score	0.9	1.1	1.5	1.2	-1.1	1.1	-1.0	0.8
Locomotion velocity, session 1	0.2	0.3	0.8	0.5	-0.4	0.3	-0.2	0.9
Locomotion distance, session 1	0.6	0.7	1.2	1.0	-1.1	1.0	-0.6	0.2
Locomotion velocity, session 2	1.5	1.8	2.7	1.6	-1.5	1.4	-1.1	1.0
Locomotion distance, session 2	0.3	0.5	0.7	0.8	-0.9	0.8	-0.5	0.2
Locomotion velocity, session 3	2.5	2.9	3.6	1.9	-1.7	1.6	-1.4	1.9
Locomotion distance, session 3	5.2	6.0	7.8	2.8	-2.6	2.5	-2.4	1.7
Stereotopy head waving bouts, day 3	0.1	0.2	0.7	-0.1	0.3	-0.3	0.2	0.8
Stereotopy head waving duration, day 3	0.8	1.0	1.3	-0.9	1.1	-1.1	0.9	0.8
Locomotion velocity, session 7	0.3	0.3	0.5	0.6	-0.6	0.6	-0.7	-0.4
Locomotion distance, session 7	0.4	0.5	0.8	0.8	-0.8	0.8	-0.9	0.2
Stereotopy head waving bouts, day 7	0.2	0.2	0.3	-0.3	0.3	-0.3	0.5	-0.6
Stereotopy head waving duration, day 7	0.1	0.1	0.2	-0.3	0.4	-0.4	0.3	0.0
Locomotion velocity, session 8	0.9	1.1	1.7	1.3	-1.3	1.1	-0.6	0.8
Locomotion distance, session 8	2.4	3.6	5.0	2.2	-2.1	2.0	-1.7	1.1
Degree of sensitization distance	2.2	2.3	3.1	-1.8	1.7	-1.6	1.3	-1.3
Degree of sensitization stereotypy	0.3	0.3	1.1	-0.2	0.1	-0.2	0.5	-1.0
Conditioned locomotion	0.9	1.1	1.9	0.8	-1.0	1.1	-0.8	-1.4
Cocaine response after cond. corrected	2.4	3.5	5.2	2.0	-2.0	2.1	-2.3	0.2
Cocaine response after cond. not corrected	2.2	3.2	4.2	2.0	-2.0	2.0	-2.0	0.3
Cocaine response before conditioning	0.1	0.1	0.3	-0.0	-0.1	-0.1	0.6	-0.0
Saline control response	0.4	0.6	0.9	0.9	-0.8	0.7	-0.6	0.6
Bone: connectivity density	0.9	1.5	2.2	-1.2	1.3	-1.4	1.5	0.4
Bone: cortical apparent density	0.0	0.0	0.1	0.1	-0.3	0.2	0.1	0.0
Bone: cortical area	0.0	0.1	0.1	0.0	-0.2	0.0	0.4	-0.4
Bone: cortical porosity	1.2	1.3	5.8	-0.5	0.1	-0.0	0.4	-2.4
Bone: cortical porosity	1.1	1.3	5.0	-0.8	0.3	-0.3	0.7	-2.2
Bone: cortical thickness	0.2	0.3	0.7	-0.5	0.3	-0.5	0.9	-0.3
Bone: cortical thickness	0.3	0.4	0.8	0.8	-0.9	0.7	-0.3	-0.1
Bone: cortical tissue density	0.0	0.0	0.1	0.2	-0.3	0.2	0.1	0.2
Condit. Reinf. active minus inactive responses	2.5	2.8	3.8	-1.9	1.9	-1.9	1.7	-0.1
Condit. Reinf. active-inactive response ratio	1.7	1.8	2.5	-1.6	1.4	-1.5	1.4	-0.5
Condit. Reinf. active responses	0.7	0.9	1.2	-1.0	1.0	-1.1	1.1	0.3
Condit. Reinf. inactive responses	0.3	0.4	0.8	0.7	-0.7	0.6	-0.2	0.9
Incentive salience index mean	1.3	1.7	2.3	-1.5	1.4	-1.4	1.4	-0.1
Condit. Reinf. lever presses	0.1	0.2	0.3	-0.4	0.3	-0.3	0.6	-0.3
Condit. Reinf. active minus inactive responses	1.8	2.8	3.5	1.9	-1.8	1.6	-1.5	1.6
Condit. Reinf. active-inactive response ratio	1.4	2.3	2.9	1.7	-1.7	1.6	-1.5	0.9
Condit. Reinf. active responses	0.6	0.8	1.5	1.0	-1.0	0.8	-0.4	1.2
Condit. Reinf. inactive responses	0.2	0.2	0.4	-0.3	0.3	-0.5	0.6	0.6
Condit. Reinf. lever presses	0.4	0.6	1.0	0.9	-0.6	0.6	-0.5	1.0
Condit. Reinf. lever reinforcers received	0.8	1.2	2.0	1.2	-1.1	0.9	-0.7	1.4
Conditioned reinforcement - actives	0.5	1.8	2.7	1.6	-1.6	1.5	-1.3	-0.0
Conditioned reinforcement - inactives	1.1	3.1	4.1	1.8	-2.0	2.0	-1.5	-1.4
Conditioned locomotion	0.6	0.9	1.3	1.0	-1.1	1.1	-0.7	-0.8
Patch foraging indifference point 0 sec	1.1	3.2	7.3	1.8	-1.3	1.3	-1.5	2.7
Patch foraging indifference point AUC	0.2	0.5	1.2	-0.6	0.3	-0.4	1.1	-0.7
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	-0.3	-0.0	-0.1	0.4	0.3
Delay disc. indifference point, 16s delay	0.6	0.9	3.8	0.6	-0.4	0.3	-0.2	1.9
Delay disc. indifference point, 2s delay	0.6	0.6	1.2	-0.7	0.5	-0.7	1.1	0.8
Delay disc. indifference point, 24s delay	0.5	0.8	1.3	0.9	-1.0	0.8	-0.3	1.1
Delay disc. indifference point, 4s delay	0.2	0.2	0.5	-0.5	0.3	-0.4	0.7	-0.5
Delay disc. indifference point, 8s delay	0.7	1.2	1.7	-0.8	0.9	-1.1	1.3	1.3
Indifference point function ln k	1.4	4.1	5.4	2.2	-1.9	2.0	-2.3	1.7
Indifference point function log k	1.4	4.1	5.4	2.2	-1.9	2.0	-2.3	1.7
Patch foraging total patch changes 0 sec	1.3	3.7	6.5	2.0	-1.6	1.6	-1.7	2.6
Patch foraging total patch changes 12 sec	0.0	0.0	0.1	0.1	-0.0	0.1	-0.0	0.3
Patch foraging total patch changes 18 sec	0.0	0.1	0.2	-0.0	-0.0	-0.1	0.5	0.1
Patch foraging total patch changes 24 sec	0.8	2.6	4.2	1.8	-2.1	1.9	-1.4	-0.0
Patch foraging total patch changes 6 sec	0.3	0.5	2.5	0.2	0.0	-0.1	0.1	1.6
Patch foraging time to switch 0 sec	1.0	3.8	5.4	-2.3	2.2	-2.0	1.6	-1.5
Patch foraging water rate 0 sec	0.8	3.0	4.0	2.0	-1.7	1.6	-1.7	1.6
Patch foraging water rate 12 sec	1.8	7.4	9.6	3.0	-3.1	3.0	-2.8	1.0
Patch foraging water rate 18 sec	2.1	4.8	6.5	2.6	-2.4	2.4	-2.2	0.9
Patch foraging water rate 24 sec	1.4	2.0	2.8	1.7	-1.6	1.5	-1.2	0.9
Patch foraging water rate 6 sec	9.2	13.5	16.1	4.0	-3.7	3.6	-3.6	3.5
Seeking ratio, delayed vs. immediate footshock	1.8	2.5	3.3	-1.7	1.8	-1.8	1.6	-0.8
Distance traveled before self-admin	0.4	0.9	1.2	1.0	-1.1	1.0	-0.9	-0.6
Distance traveled after self-admin	0.9	1.5	2.4	1.5	-1.5	1.4	-1.0	-0.1
Extensor digitorum longus weight	4.8	19.0	26.4	-4.6	4.2	-4.4	5.1	-3.3
Bone: elastic displacement	0.8	1.0	1.6	-1.2	1.3	-1.1	0.6	-0.8
Bone: elastic work	0.1	0.2	0.5	-0.4	0.4	-0.3	0.0	-0.7
Bone: endosteal estimation	1.2	2.8	3.8	1.8	-1.9	1.9	-1.9	-0.1
Bone: endosteal perimeter	0.0	0.1	0.1	0.3	-0.4	0.3	-0.1	-0.1
Epididymis fat weight	0.2	1.0	3.1	-0.3	0.8	-0.9	0.4	1.8
Delta time in closed arm before/after self-admin	3.2	3.0	3.5	-1.9	1.6	-1.7	1.9	-1.6
Delta time in open arm before/after self-admin	0.2	0.3	0.6	-0.4	0.6	-0.4	0.1	-0.8
Diff in mean of infusions in LGA sessions	0.0	0.1	0.3	0.0	-0.1	-0.0	0.2	0.6
Delay discount exponential model param	0.5	0.7	2.0	0.4	-0.4	0.6	-0.9	-1.4
Extinction: sum of active levers before priming	1.7	2.6	3.1	-1.8	1.6	-1.6	1.4	-1.6
Active lever presses in extinction session 6	2.5	2.5	3.2	-1.6	1.7	-1.6	1.1	-1.8
Bone: final force	0.6	0.9	1.5	1.1	-1.2	1.1	-0.8	-0.4
Bone: final moment	0.9	1.5	2.3	1.4	-1.5	1.4	-1.1	-0.3
Food consumed during 24 hour testing period	0.6	1.2	1.6	1.2	-1.2	1.2	-1.1	0.2
Glucose	0.1	0.2	0.4	0.1	-0.3	0.4	-0.6	-0.6
Heart weight	0.3	0.6	1.1	0.9	-0.6	0.7	-1.0	-0.4
Delay discount hyperbolic model param	0.5	0.6	1.7	0.4	-0.4	0.6	-0.9	-1.3
Intermittent access intake day 1-15 change	0.1	0.8	3.5	0.3	-0.5	0.5	-0.2	-1.9
Intermittent access intake escalation	0.2	1.2	3.1	0.8	-0.9	1.0	-0.6	-1.8
Intermittent access intake escalation 2	0.4	0.7	2.4	-0.5	0.4	-0.4	0.6	-1.6
Intermitt. access day 1 inactive lever presses	0.1	1.4	2.9	-1.1	1.0	-1.0	0.9	-1.7
Intermitt. access day 15 inactive lever presses	0.1	0.6	1.8	-0.7	0.7	-0.5	0.4	-1.3
Intermitt. access escalation Index	0.1	0.4	0.4	0.6	-0.7	0.6	-0.5	0.6
Intermittent access day 1 total infusions	0.7	2.1	2.7	1.7	-1.6	1.5	-1.6	0.4
Intermittent access day 15 total infusions	1.6	4.0	5.2	2.3	-2.1	2.2	-2.3	-0.4
Intermittent access terminal intake (last 3 days)	1.2	2.1	2.5	1.6	-1.4	1.5	-1.6	-1.0
Intermittent access total infusions	3.0	3.6	4.8	2.2	-2.1	2.1	-2.1	0.1
Intermittent access day 1 locomotion	2.0	3.8	4.8	2.2	-2.1	2.2	-2.2	0.0
Intermittent access day 15 total locomotion	0.9	3.6	5.5	2.2	-1.8	2.0	-2.3	0.8
Intermittent access total locomotion	4.9	5.9	7.9	2.8	-2.6	2.7	-2.7	0.3
Intermittent access standard deviation	0.5	2.5	6.5	1.1	-1.4	1.4	-1.0	-2.6
Left kidney weight	0.5	3.7	5.4	2.2	-1.6	1.6	-1.7	2.3
Right kidney weight	0.5	3.6	8.4	2.0	-1.4	1.3	-1.4	2.9
Cocaine induced anxiety	0.3	0.9	1.2	1.0	-0.9	1.0	-1.1	0.7
Post-drug Anxiety	0.5	0.6	0.8	0.9	-0.8	0.9	-0.8	-0.1
Baseline Anxiety	0.4	0.7	1.2	-0.8	0.7	-0.8	1.1	-0.7
Tail length	3.7	19.7	27.8	4.7	-3.9	3.8	-4.3	5.3
Length with tail	6.1	27.0	48.7	5.4	-4.2	4.1	-4.7	7.0
Length without tail	2.3	12.2	27.5	3.5	-2.5	2.4	-3.0	5.2
Times rat made contact with spout	0.9	1.0	3.7	0.3	-0.6	0.7	-0.5	-1.9
Lifetime Intake	2.1	2.6	3.5	1.9	-1.7	1.7	-1.8	0.4
Liver weight, left	1.3	2.3	4.5	1.6	-1.2	1.1	-1.3	2.1
Liver weight, right	0.3	0.5	0.8	-0.6	0.7	-0.8	0.9	0.6
Locomotor activity	0.3	0.4	0.6	0.7	-0.7	0.7	-0.8	0.4
Locomotor testing distance	0.1	0.2	0.4	-0.5	0.4	-0.5	0.4	-0.6
Locomotor testing rearing	0.1	0.4	1.1	0.2	-0.3	0.4	-0.6	-1.1
Locomotion in novel chamber	0.5	0.7	2.1	0.4	-0.6	0.7	-0.5	-1.5
Locomotion in novel chamber post-restriction	0.0	0.1	0.4	-0.2	0.3	-0.3	0.3	0.7
Fecal boli incidents, locomotor time 1	0.4	1.0	1.8	-0.9	1.0	-0.9	0.7	-1.3
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	-0.0	0.0	0.0	0.0	-0.1
Time >=10cm from walls, locomotor time 1	0.8	1.0	1.6	-1.0	1.0	-0.8	0.9	-1.3
Bouts of movement, locomotor time 1	0.1	0.1	0.3	0.0	0.1	0.1	-0.5	-0.5
Total resting periods, locomotor time 1	0.2	0.3	0.7	0.5	-0.4	0.5	-0.8	-0.1
Rest time, locomotor task time 1	0.1	0.2	1.1	-0.2	0.3	0.0	-0.0	-1.0
Distance moved, locomotor task time 1	0.2	0.6	1.3	0.7	-0.8	0.5	-0.3	1.1
Vertical activity count, locomotor time 1	0.1	0.8	1.3	1.0	-1.2	1.0	-0.7	0.7
Time >=10cm from walls, locomotor time 2	0.6	1.6	2.2	-1.4	1.3	-1.4	1.5	-0.2
Bouts of movement, locomotor time 2	0.1	0.3	1.4	-0.1	0.2	-0.3	0.0	1.2
Total resting periods, locomotor time 2	0.0	0.1	0.4	-0.3	0.3	-0.4	0.1	0.7
Rest time, locomotor task time 2	0.7	1.3	4.6	-0.9	0.7	-0.4	0.6	-2.1
Distance moved, locomotor task time 2	0.5	0.6	2.8	0.3	-0.3	-0.0	0.2	1.7
Vertical activity count, locomotor time 2	0.1	0.1	0.3	0.4	-0.5	0.4	-0.2	-0.2
Light reinforcement 1	0.6	2.6	3.1	1.8	-1.6	1.5	-1.5	1.6
Light reinforcement 2	0.1	0.2	1.1	-0.1	-0.1	0.1	-0.0	-1.0
Bone: marrow area	1.2	2.9	3.9	1.9	-1.9	2.0	-1.9	-0.1
Bone: maximum diameter	0.3	0.5	1.0	-0.7	0.4	-0.5	1.0	-0.8
Bone: maximum force	0.1	0.1	0.3	0.4	-0.5	0.4	-0.2	-0.2
Bone: maximum moment	0.2	0.5	0.7	0.8	-0.9	0.8	-0.5	-0.1
Mean time between licks in bursts	0.1	0.5	0.9	-0.6	0.4	-0.5	0.9	-0.9
Mean num. licks in bursts	0.5	1.5	2.1	1.4	-1.2	1.3	-1.5	0.4
Cd content in liver	0.9	1.0	4.0	-0.1	0.6	-0.6	0.1	2.0
Co content in liver	0.3	0.4	0.5	-0.6	0.6	-0.7	0.7	0.3
Cu content in liver	0.4	0.4	0.9	0.5	-0.7	0.7	-0.2	-1.0
Fe content in liver	0.6	0.7	1.4	0.9	-0.8	0.7	-0.7	1.2
K content in liver	5.1	5.0	7.4	2.4	-2.7	2.7	-1.9	-1.0
Mg content in liver	1.3	1.5	1.9	1.1	-1.3	1.4	-0.9	-1.3
Mn content in liver	0.7	0.8	1.2	1.0	-1.0	1.1	-0.8	-0.4
Na content in liver	0.3	0.3	0.7	0.5	-0.8	0.7	-0.2	-0.1
Rb content in liver	0.4	0.4	0.8	0.9	-0.7	0.7	-0.7	-0.1
Se content in liver	0.7	0.9	1.7	-0.8	0.5	-0.5	1.2	-1.3
Sr content in liver	1.4	1.2	1.7	-1.3	1.1	-1.2	1.1	-0.5
Zn content in liver	0.3	0.4	0.5	0.6	-0.7	0.7	-0.6	0.1
Bone: minimum diameter	2.4	4.6	6.4	2.5	-2.5	2.5	-2.1	0.4
Time in familiar zone, hab. session 1	2.2	2.5	3.2	1.8	-1.6	1.6	-1.5	1.4
Time in novel zone, hab. session 1	5.0	5.6	7.2	-2.7	2.7	-2.6	2.3	-1.3
Total zone transitions, hab. session 1	0.3	0.4	0.6	-0.6	0.7	-0.8	0.8	0.2
Total locomotion distance, hab. session 1	0.2	0.3	0.4	0.6	-0.6	0.6	-0.6	-0.0
Locomotion velocity, hab. session 1	0.3	0.4	0.6	0.7	-0.7	0.7	-0.7	-0.0
Time in familiar zone, hab. session 2	1.9	2.1	2.9	1.5	-1.3	1.3	-1.7	1.4
Time in novel zone, hab. session 2	2.8	3.1	3.7	-1.8	1.6	-1.6	1.9	-1.9
Total zone transitions, hab. session 2	0.6	0.7	1.1	0.7	-1.0	0.9	-0.4	-1.0
Total locomotion distance, hab. session 2	0.5	0.6	0.9	0.6	-0.8	0.8	-0.6	-1.0
Locomotion velocity, hab. session 2	0.8	1.1	1.6	1.0	-1.3	1.2	-0.9	-0.7
Novel to familiar place preference ratio	2.6	3.4	4.2	-2.0	2.0	-2.0	1.9	-1.0
Novelty place preference	2.4	3.1	3.9	-1.9	2.0	-1.9	1.9	-1.0
Time in novel zone, NPP test	2.8	3.4	4.1	-2.0	2.0	-2.0	2.0	-1.2
Total zone transitions, NPP test	0.8	1.1	1.7	1.2	-1.3	1.2	-0.9	0.3
Total locomotion distance, NPP test	0.2	0.3	0.6	0.6	-0.7	0.7	-0.4	-0.3
Locomotion velocity, NPP test	1.0	1.4	2.0	1.3	-1.4	1.4	-1.1	0.0
Intraocular pressure	6.0	9.7	13.0	-3.2	2.8	-3.0	3.6	-2.9
Delta distance traveled before/after self-admin	1.7	1.9	3.7	1.3	-1.3	1.2	-1.1	1.9
Delta ambulatory time before/after self-admin	1.1	1.9	2.7	1.4	-1.3	1.3	-1.2	1.6
Parametrial fat weight	0.6	1.4	1.9	-1.0	1.4	-1.4	1.2	0.7
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.0	0.0	0.0	-0.2	-0.6
Pavlov. Cond. magazine entry latency	1.0	1.2	5.0	0.7	-0.4	0.4	-0.5	2.2
Pavlov. Cond. change in total contacts	1.1	1.2	3.9	0.9	-0.6	0.5	-0.6	2.0
Pavlov. Cond. index score	0.5	0.6	2.4	0.5	-0.4	0.3	-0.3	1.6
Pavlov. Cond. latency score	0.3	0.4	1.9	0.2	-0.0	-0.0	0.0	1.4
Pavlov. Cond. lever contacts	0.3	0.4	1.2	0.6	-0.5	0.4	-0.3	1.1
Pavlov. Cond. magazine entry number	1.4	1.8	5.9	-1.1	0.8	-0.7	0.8	-2.4
Pavlov. Cond. intertrial magazine entries	9.4	11.3	14.0	-3.7	3.7	-3.7	3.7	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	2.8	0.6	-0.4	0.3	-0.3	1.7
Pavlov. Cond. response bias	1.2	1.5	3.7	1.2	-1.0	0.8	-0.7	1.9
Pavlov. Cond. lever latency	0.8	1.1	1.9	-1.1	0.8	-0.8	1.0	-1.4
Pavlov. Cond. magazine entry latency	0.6	0.8	1.2	1.1	-0.9	1.0	-1.0	0.4
Pavlov. Cond. change in total contacts	1.5	3.7	5.1	2.2	-2.0	1.9	-1.9	1.5
Pavlov. Cond. index score	0.9	1.5	2.1	1.5	-1.2	1.2	-1.3	0.9
Pavlov. Cond. latency score	1.1	1.7	2.4	1.5	-1.3	1.3	-1.4	0.9
Pavlov. Cond. lever contacts	0.4	0.7	1.3	0.9	-0.5	0.5	-0.7	1.2
Pavlov. Cond. magazine entry number	1.6	2.0	2.7	-1.6	1.4	-1.5	1.5	-0.9
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	-0.2	0.2	-0.3	0.5	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.4	2.1	1.4	-1.1	1.2	-1.2	0.9
Pavlov. Cond. response bias	0.4	0.6	0.8	0.9	-0.6	0.6	-0.7	0.9
Time in closed arm before self-admin	0.5	0.9	1.3	1.0	-1.1	1.1	-0.8	0.6
Time in closed arm after self-admin	0.3	0.3	0.6	0.5	-0.8	0.6	-0.2	0.5
Time in open arm before self-admin	1.2	1.4	3.2	-0.8	1.2	-1.2	0.7	1.8
Time in open arm after self-admin	1.6	1.8	3.0	-1.5	1.7	-1.6	1.0	-0.5
Bone: periosteal estimation	0.4	1.0	1.3	1.1	-1.2	1.1	-0.9	-0.2
Bone: periosteal perimeter	0.0	0.0	0.1	0.1	-0.2	0.1	0.3	-0.1
Bone: post-yield work	0.6	1.1	2.7	-0.6	0.7	-0.9	1.1	1.6
Progressive ratio test 1 active lever presses	1.7	2.9	4.2	2.0	-1.8	1.8	-2.0	0.5
Progressive ratio test 1 breakpoint	1.7	2.9	4.1	2.0	-1.8	1.8	-2.0	0.6
Progressive ratio test 1 inactive lever presses	0.3	0.8	1.1	0.9	-1.0	0.9	-0.8	-0.7
Progressive ratio test 2 active lever presses	1.6	2.3	3.2	1.8	-1.6	1.7	-1.8	0.1
Progressive ratio test 2 breakpoint	2.0	2.5	3.5	1.9	-1.6	1.7	-1.9	0.1
Progressive ratio test 2 inactive lever presses	0.3	0.8	1.1	1.0	-1.0	1.0	-0.9	-0.4
Incentive Sensitization - Responses	0.6	1.7	2.4	1.5	-1.3	1.4	-1.4	0.6
Incentive Sensitization - Breakpoint	0.5	1.2	1.8	1.3	-1.1	1.2	-1.3	0.5
Sum of active levers in priming session hrs 5-6	2.0	1.8	2.8	-1.6	1.7	-1.6	1.2	0.0
Progressive ratio	0.8	2.3	4.9	-1.0	1.3	-1.4	1.2	2.2
Food seeking constrained by brief footshock	3.4	4.2	5.2	2.2	-2.3	2.2	-2.0	1.4
Seeking ratio, punishment vs. effort	2.5	5.5	7.5	2.4	-2.7	2.7	-2.5	-1.1
Retroperitoneal fat weight	0.4	1.7	2.7	-1.1	1.6	-1.6	1.1	0.7
Reaction time number correct	2.3	8.2	11.6	3.4	-3.2	3.2	-2.8	1.1
Reaction time mean minus median	0.0	0.1	0.1	0.2	-0.3	0.3	-0.1	0.2
Reaction time mean minus median AUC	0.1	0.4	0.6	0.7	-0.8	0.8	-0.6	0.1
Reaction time num false alarms	0.4	0.6	1.4	-0.9	0.6	-0.7	1.2	-0.4
Reaction time num false alarms AUC	0.6	1.3	2.3	-1.2	1.0	-1.1	1.5	-0.6
Reaction time trials correct on left	2.3	8.2	11.6	3.4	-3.2	3.2	-2.8	1.1
Reaction time trials on left	2.4	8.3	11.7	3.4	-3.2	3.2	-2.8	1.1
Reaction time mean	1.2	2.6	3.1	-1.8	1.7	-1.7	1.7	-1.1
Reaction time mean AUC	0.8	2.0	2.6	-1.6	1.6	-1.5	1.4	-0.8
Median of all reaction times	2.7	4.3	5.2	-2.3	2.2	-2.2	2.1	-1.3
Reaction time omissions	0.1	0.2	0.3	0.4	-0.3	0.3	-0.5	0.6
Reaction time false alarm rate	4.8	6.6	8.8	-3.0	2.7	-2.7	2.9	-1.0
Reaction time premature initiation rate	3.9	6.0	7.4	2.7	-2.6	2.6	-2.7	1.2
Reaction time premature initiations	4.5	13.6	17.9	4.2	-4.1	4.0	-3.9	1.6
Std. dev. reaction times	0.1	0.2	0.4	-0.4	0.4	-0.4	0.4	-0.6
Reaction time trials completed	2.4	8.3	11.7	3.4	-3.2	3.2	-2.8	1.1
Reaction time trials AUC	2.1	7.2	10.2	3.2	-3.0	3.0	-2.6	1.0
Run reversals in cocaine runway, females	1.3	1.4	2.7	-1.0	0.7	-0.9	1.6	-1.4
Run reversals in cocaine runway, males	0.2	0.2	0.3	-0.3	0.6	-0.5	0.2	0.4
Latency to leave start box in cocaine runway	0.9	1.2	1.8	-1.3	1.1	-1.1	1.3	-0.6
Latency to leave start box in cocaine runway, F	0.0	0.0	0.0	-0.2	0.1	-0.1	-0.0	-0.1
Latency to leave start box in cocaine runway, M	1.5	1.4	2.4	-1.4	1.2	-1.2	1.6	-0.2
Std. dev. time between licks in bursts	0.1	0.3	1.3	-0.2	-0.0	0.0	0.2	-1.1
Total sessions with >9 infusions	0.5	0.7	1.0	0.9	-0.9	0.8	-1.0	0.0
Short access day 1 total inactive lever presses	0.2	0.4	0.5	0.7	-0.4	0.4	-0.7	0.7
Short access day 10 total inactive lever presses	0.1	0.5	1.4	-0.5	0.3	-0.3	0.7	-1.2
Short access day 1 total infusions	0.2	0.4	0.8	0.7	-0.7	0.6	-0.9	-0.0
Short access day 10 total infusions	0.8	1.3	1.8	1.4	-1.2	1.2	-1.3	0.3
Short access total infusions	0.6	0.9	1.3	1.1	-0.9	0.9	-1.1	0.4
Short access day 1 locomotion	0.1	0.2	0.7	0.2	-0.3	0.2	-0.1	-0.9
Short access day 10 total locomotion	0.2	0.8	3.4	-0.4	0.3	-0.2	0.2	-1.9
Short access total locomotion	0.8	1.1	1.2	1.1	-1.1	1.1	-1.1	-1.0
One hour access (0.3 mA shock)	0.4	0.4	0.7	0.8	-0.4	0.4	-0.8	0.8
Compulsive drug intake	1.5	2.2	3.2	-1.6	1.4	-1.5	1.8	-1.1
One hour access (shock baseline)	1.4	3.7	5.6	2.2	-1.8	1.9	-2.4	0.9
Social response proportion	0.5	0.6	1.1	-0.7	1.1	-0.9	0.5	-0.3
Social responses	0.5	0.7	3.0	0.4	0.1	-0.0	-0.4	1.7
Social time	0.0	0.1	0.3	-0.0	0.1	-0.0	-0.0	-0.6
Soleus weight	0.5	1.5	2.6	-1.2	1.0	-1.2	1.6	-0.9
Bone: stiffness	0.1	0.2	0.4	0.5	-0.6	0.5	-0.0	-0.0
Tibialis anterior weight	2.2	7.6	11.0	-3.0	2.5	-2.7	3.3	-2.0
Time to tail flick, vehicle, before self-admin	2.4	3.0	4.3	1.9	-2.1	1.9	-1.6	-0.9
Time to tail flick, vehicle, after self-admin	0.6	1.2	5.4	0.3	-0.5	0.4	-0.2	-2.3
Time to tail flick, test, before self-admin	0.2	0.2	0.6	-0.2	0.4	-0.2	-0.4	-0.8
Time to tail flick, test, after self-admin	0.2	0.2	0.9	-0.4	0.2	-0.1	0.1	-1.0
Delta time to tail flick, vehicle, before/after SA	1.8	1.9	2.8	-1.3	1.3	-1.2	1.3	-1.7
Delta time to tail flick, test, before/after SA	0.2	0.2	0.6	0.3	-0.5	0.4	0.0	0.8
Tibia length	4.4	12.1	15.9	4.0	-3.6	3.6	-3.5	2.5
Ambulatory time before self-admin	0.1	0.3	0.8	0.4	-0.5	0.4	-0.2	-0.9
Ambulatory time after self-admin	0.9	1.4	2.3	1.4	-1.5	1.4	-0.9	-0.3
Bone: tissue strength	0.6	0.6	1.0	-0.9	1.0	-0.9	0.6	0.0
Total heroin consumption	1.0	1.2	4.4	-0.8	0.8	-0.6	0.4	-2.1
Bone: trabecular number	0.4	0.8	1.3	-0.8	0.9	-1.1	1.1	0.2
Bone: trabecular spacing	0.2	0.4	0.5	0.4	-0.6	0.6	-0.5	-0.7
Bone: trabecular thickness	0.9	1.2	1.6	-1.1	0.9	-1.0	1.3	-1.2
Bone: trabecular tissue density	1.0	1.8	7.7	-0.8	0.1	-0.2	0.8	-2.8
Water consumed over 24 hours	0.6	1.1	5.6	-0.0	-0.2	0.3	-0.2	-2.4
Number of responses in last shaping day	0.3	0.4	1.7	-0.2	0.1	-0.1	0.0	-1.3