Rnd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Rnd1	0.14	0.09	0.0e+00	0.16	0.17	0.16	0.16	1.8e-14	7.6e-16	1.2e-14	9.0e-15
2	BLA	gene expression	Rnd1	0.12	0.08	7.3e-07	0.1	0.1	0.09	0.11	7.0e-06	4.1e-06	1.5e-05	2.9e-06
3	Liver	gene expression	Rnd1	0.04	0.03	5.5e-06	0.05	0.04	0.05	0.05	2.0e-06	1.4e-05	4.8e-06	3.8e-06
4	pVTA	gene expression	Rnd1	0.15	0.09	1.1e-15	0.18	0.19	0.19	0.19	1.3e-14	2.7e-15	6.4e-15	3.3e-15
5	Adipose	gene expression	Rnd1	0.02	0.02	4.9e-03	0.01	0.01	0.01	0.01	3.5e-02	1.5e-02	6.1e-02	4.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	9.9	17.0	18.4	4.3	4.2	4.3	3.9	-3.9
Area under the delay curve	1.0	1.2	2.4	1.1	0.9	1.5	0.9	-0.9
BMI with tail	6.5	22.6	26.6	5.2	4.7	4.3	4.8	-4.7
BMI without tail	2.1	6.3	8.6	2.5	2.2	2.9	2.5	-2.4
Body weight	7.1	30.9	34.1	5.8	5.4	5.5	5.6	-5.5
Weight adjusted by age	2.4	3.7	4.8	1.8	2.0	1.3	2.2	-2.2
Bone surface	11.6	21.2	22.5	4.7	4.7	4.6	4.5	-4.4
Bone volume	8.9	16.0	17.3	4.2	4.1	4.0	3.9	-3.9
Breakpoint value in progressive ratio session	1.6	2.0	3.7	1.3	1.2	1.9	1.2	-1.3
Number of licking bursts	0.2	0.3	0.6	-0.7	-0.8	-0.3	-0.2	0.2
Context. condit. distance diff. score	0.3	0.4	0.4	0.6	0.6	0.6	0.7	-0.6
Locomotion velocity, session 1	0.9	1.0	1.3	-1.1	-0.9	-1.1	-0.9	0.9
Locomotion distance, session 1	3.1	3.9	4.3	-1.8	-1.8	-2.1	-2.1	2.1
Locomotion velocity, session 2	0.3	0.3	0.4	-0.5	-0.5	-0.7	-0.6	0.6
Locomotion distance, session 2	2.5	3.4	3.9	-1.7	-1.7	-1.9	-2.0	2.0
Locomotion velocity, session 3	4.1	4.7	4.9	-2.1	-2.1	-2.2	-2.2	2.2
Locomotion distance, session 3	5.1	5.6	5.9	-2.3	-2.3	-2.4	-2.4	2.4
Stereotopy head waving bouts, day 3	1.2	1.4	1.7	1.1	1.3	0.9	1.3	-1.3
Stereotopy head waving duration, day 3	0.6	0.7	1.0	0.8	1.0	0.4	0.9	-0.9
Locomotion velocity, session 7	0.1	0.1	0.2	-0.5	-0.4	-0.2	-0.3	0.3
Locomotion distance, session 7	1.2	1.5	2.0	-1.4	-1.3	-0.8	-1.2	1.2
Stereotopy head waving bouts, day 7	1.3	1.5	2.2	1.1	1.3	0.6	1.4	-1.5
Stereotopy head waving duration, day 7	1.0	1.2	1.7	1.0	1.2	0.5	1.3	-1.3
Locomotion velocity, session 8	0.0	0.0	0.0	0.1	-0.0	0.0	0.1	-0.1
Locomotion distance, session 8	1.3	1.9	2.4	-1.2	-1.2	-1.6	-1.4	1.4
Degree of sensitization distance	0.7	0.7	1.2	0.7	0.7	1.1	0.9	-0.9
Degree of sensitization stereotypy	0.2	0.2	0.4	0.3	0.3	-0.1	0.6	-0.6
Conditioned locomotion	0.2	0.2	0.5	-0.2	0.2	0.7	0.4	-0.4
Cocaine response after cond. corrected	0.1	0.1	0.2	0.2	-0.1	-0.1	-0.3	0.4
Cocaine response after cond. not corrected	0.8	1.0	1.4	-0.6	-0.8	-1.2	-1.1	1.1
Cocaine response before conditioning	4.3	5.2	6.8	-2.4	-2.1	-2.6	-2.2	2.1
Saline control response	0.0	0.1	0.2	0.1	0.2	0.4	-0.0	-0.0
Bone: connectivity density	6.8	10.7	12.1	3.4	3.4	3.5	3.0	-3.0
Bone: cortical apparent density	0.2	0.3	0.5	-0.7	-0.5	-0.3	-0.5	0.4
Bone: cortical area	12.1	18.6	19.6	4.3	4.2	4.4	4.3	-4.3
Bone: cortical porosity	1.1	1.2	2.0	-1.2	-0.7	-1.4	-1.1	1.0
Bone: cortical porosity	1.4	1.5	2.3	-1.3	-0.8	-1.5	-1.2	1.1
Bone: cortical thickness	5.1	8.5	10.2	2.9	2.6	3.2	2.9	-2.8
Bone: cortical thickness	0.3	0.3	0.6	0.6	0.4	0.8	0.6	-0.5
Bone: cortical tissue density	0.3	0.4	0.7	-0.8	-0.6	-0.4	-0.6	0.5
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.1	-0.2	-0.3	-0.4	0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	0.6	0.6	0.5	0.3	-0.3
Condit. Reinf. active responses	0.6	0.8	1.0	-0.7	-0.8	-1.0	-0.9	0.9
Condit. Reinf. inactive responses	2.9	3.5	4.1	-1.8	-1.9	-2.0	-1.8	1.8
Incentive salience index mean	0.0	0.0	0.1	0.3	0.1	0.2	0.1	-0.1
Condit. Reinf. lever presses	0.2	0.3	0.4	0.6	0.4	0.6	0.6	-0.5
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	-0.2	-0.1	-0.4	-0.2	0.1
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.8	-0.6	-0.6	-0.9	-0.6	0.6
Condit. Reinf. active responses	0.3	0.3	0.5	-0.6	-0.5	-0.7	-0.6	0.5
Condit. Reinf. inactive responses	0.6	0.8	1.0	-1.0	-0.8	-0.9	-0.8	0.8
Condit. Reinf. lever presses	0.0	0.0	0.0	0.1	0.1	0.2	0.0	-0.0
Condit. Reinf. lever reinforcers received	0.6	0.8	1.0	-0.9	-0.8	-1.0	-0.9	0.8
Conditioned reinforcement - actives	0.8	1.4	1.8	-1.2	-1.3	-1.0	-1.1	1.1
Conditioned reinforcement - inactives	3.3	4.9	5.6	-2.3	-2.4	-1.9	-2.2	2.3
Conditioned locomotion	0.1	0.2	0.4	-0.6	-0.4	-0.3	-0.4	0.3
Patch foraging indifference point 0 sec	1.8	3.4	3.8	-1.8	-1.9	-1.6	-1.9	1.9
Patch foraging indifference point AUC	0.8	1.2	1.6	-1.1	-1.0	-1.3	-1.0	1.0
Delay disc. indifference point, 0s delay	1.3	1.5	1.7	1.1	1.2	1.3	1.2	-1.2
Delay disc. indifference point, 16s delay	1.1	1.2	2.1	1.0	0.8	1.5	1.0	-1.0
Delay disc. indifference point, 2s delay	1.1	1.2	1.4	1.1	1.2	0.9	1.1	-1.1
Delay disc. indifference point, 24s delay	1.2	1.3	1.6	1.1	1.1	1.3	1.1	-1.1
Delay disc. indifference point, 4s delay	0.5	0.5	1.2	0.8	0.5	1.1	0.5	-0.4
Delay disc. indifference point, 8s delay	2.4	2.9	4.8	1.8	1.4	2.2	1.5	-1.4
Indifference point function ln k	3.1	5.3	5.6	2.2	2.4	2.3	2.3	-2.3
Indifference point function log k	3.1	5.3	5.6	2.2	2.4	2.3	2.3	-2.3
Patch foraging total patch changes 0 sec	1.8	3.3	3.8	-1.8	-1.9	-1.5	-1.9	1.9
Patch foraging total patch changes 12 sec	2.2	2.8	3.2	-1.8	-1.8	-1.5	-1.7	1.7
Patch foraging total patch changes 18 sec	3.5	5.4	6.4	-2.5	-2.4	-2.1	-2.3	2.3
Patch foraging total patch changes 24 sec	1.5	2.6	3.2	-1.8	-1.7	-1.5	-1.5	1.5
Patch foraging total patch changes 6 sec	2.5	3.8	4.1	-1.9	-2.0	-1.9	-2.0	2.0
Patch foraging time to switch 0 sec	1.9	3.8	4.2	-2.0	-2.0	-2.1	-1.9	1.9
Patch foraging water rate 0 sec	2.9	6.2	8.0	2.4	2.3	2.8	2.4	-2.4
Patch foraging water rate 12 sec	2.7	5.7	6.1	2.3	2.5	2.4	2.4	-2.4
Patch foraging water rate 18 sec	0.3	0.5	0.6	0.7	0.7	0.8	0.8	-0.7
Patch foraging water rate 24 sec	3.1	4.4	5.0	1.9	2.1	2.0	2.2	-2.2
Patch foraging water rate 6 sec	4.4	6.5	6.7	2.4	2.6	2.5	2.6	-2.6
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.4	0.6	0.3	0.0	0.2	-0.1
Distance traveled before self-admin	0.6	0.8	1.2	-1.1	-1.0	-0.8	-0.8	0.8
Distance traveled after self-admin	0.2	0.2	0.4	-0.4	-0.5	-0.2	-0.6	0.6
Extensor digitorum longus weight	4.5	17.6	19.0	4.1	3.9	4.4	4.4	-4.2
Bone: elastic displacement	4.4	5.1	5.6	-2.4	-2.3	-2.0	-2.3	2.3
Bone: elastic work	0.0	0.0	0.0	-0.1	0.2	0.0	-0.1	-0.0
Bone: endosteal estimation	7.9	17.3	18.6	4.1	4.3	4.0	4.1	-4.2
Bone: endosteal perimeter	7.3	15.6	16.1	4.0	4.0	3.9	4.0	-4.0
Epididymis fat weight	0.8	2.7	3.0	1.7	1.7	1.5	1.6	-1.6
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.0	-0.1	-0.3	-0.3	0.3
Delta time in open arm before/after self-admin	0.9	0.8	1.2	-1.1	-1.1	-0.6	-0.9	0.9
Diff in mean of infusions in LGA sessions	0.9	1.1	1.4	1.2	1.2	0.8	1.0	-1.0
Delay discount exponential model param	0.9	1.1	2.2	-1.0	-0.8	-1.5	-0.9	0.8
Extinction: sum of active levers before priming	1.6	1.8	2.0	1.2	1.3	1.4	1.3	-1.4
Active lever presses in extinction session 6	1.5	1.5	2.6	1.2	1.2	1.6	1.0	-1.0
Bone: final force	11.1	17.8	18.9	4.3	4.3	4.1	4.2	-4.1
Bone: final moment	11.8	18.9	20.5	4.5	4.5	4.2	4.3	-4.2
Food consumed during 24 hour testing period	1.4	1.9	2.7	1.6	1.5	1.2	1.2	-1.2
Glucose	0.3	0.4	0.9	0.5	0.3	0.9	0.7	-0.6
Heart weight	0.1	0.1	0.1	0.4	0.3	0.4	0.3	-0.3
Delay discount hyperbolic model param	0.9	1.0	2.0	-1.0	-0.8	-1.4	-0.8	0.8
Intermittent access intake day 1-15 change	0.0	0.1	0.1	-0.1	-0.3	0.2	-0.3	0.3
Intermittent access intake escalation	0.0	0.0	0.1	0.1	-0.0	0.2	-0.0	0.1
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.2	-0.4	-0.3	-0.4	0.4
Intermitt. access day 1 inactive lever presses	0.3	1.3	2.3	-1.5	-1.0	-1.2	-1.0	0.9
Intermitt. access day 15 inactive lever presses	0.7	1.4	1.7	-1.3	-1.1	-1.1	-1.2	1.2
Intermitt. access escalation Index	0.4	0.6	0.8	0.8	0.6	0.5	0.9	-0.9
Intermittent access day 1 total infusions	0.9	1.5	2.0	-1.1	-1.2	-1.4	-1.1	1.2
Intermittent access day 15 total infusions	0.7	1.0	1.2	-0.9	-1.1	-1.0	-0.9	1.0
Intermittent access terminal intake (last 3 days)	1.2	1.5	1.7	-1.2	-1.3	-1.3	-1.2	1.2
Intermittent access total infusions	1.6	1.9	2.4	-1.3	-1.5	-1.3	-1.3	1.4
Intermittent access day 1 locomotion	0.1	0.2	0.5	-0.5	-0.4	-0.7	-0.2	0.2
Intermittent access day 15 total locomotion	0.1	0.2	0.4	-0.6	-0.4	-0.5	-0.2	0.2
Intermittent access total locomotion	1.1	1.3	2.0	-1.4	-1.2	-1.1	-1.0	1.0
Intermittent access standard deviation	0.2	0.4	0.6	-0.5	-0.8	-0.4	-0.6	0.7
Left kidney weight	0.9	4.1	6.0	2.4	1.9	2.2	1.8	-1.7
Right kidney weight	4.3	19.4	21.5	4.6	4.4	4.2	4.4	-4.4
Cocaine induced anxiety	2.6	3.7	4.3	2.0	1.9	1.5	2.1	-2.1
Post-drug Anxiety	3.5	3.8	4.6	1.9	1.9	2.1	1.9	-1.9
Baseline Anxiety	0.4	0.4	2.0	0.2	0.2	1.4	0.1	-0.1
Tail length	0.1	0.2	1.0	0.2	0.1	1.0	0.2	-0.2
Length with tail	1.8	7.8	8.4	2.8	2.7	2.9	2.8	-2.7
Length without tail	5.6	18.0	21.5	4.6	4.3	3.9	4.2	-4.1
Times rat made contact with spout	0.1	0.1	0.2	-0.0	-0.4	-0.2	-0.2	0.3
Lifetime Intake	2.0	2.4	3.2	-1.5	-1.8	-1.5	-1.4	1.5
Liver weight, left	10.5	17.4	18.7	4.2	4.1	4.3	4.1	-4.1
Liver weight, right	2.6	4.5	4.7	2.1	2.2	2.1	2.1	-2.1
Locomotor activity	1.3	2.0	2.8	-1.4	-1.4	-1.7	-1.3	1.3
Locomotor testing distance	2.6	4.6	5.4	-2.3	-2.3	-2.0	-2.0	2.0
Locomotor testing rearing	1.8	3.6	4.6	-2.1	-2.1	-1.7	-1.8	1.8
Locomotion in novel chamber	1.2	1.6	1.9	1.3	1.2	1.0	1.4	-1.4
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	-0.1	-0.2	-0.3	-0.1	0.1
Fecal boli incidents, locomotor time 1	1.2	1.8	2.9	-1.0	-1.6	-0.3	-1.5	1.7
Change in fecal boli incidents, locomotor task	0.7	0.7	1.1	0.7	1.0	0.7	0.8	-0.9
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.8	0.4	0.2	1.4	0.3	-0.2
Bouts of movement, locomotor time 1	0.0	0.0	0.1	0.2	0.1	0.2	0.1	-0.0
Total resting periods, locomotor time 1	0.1	0.2	0.3	-0.3	-0.5	0.0	-0.5	0.5
Rest time, locomotor task time 1	0.2	0.2	0.3	-0.3	-0.5	0.3	-0.5	0.6
Distance moved, locomotor task time 1	0.1	0.2	0.7	-0.0	0.2	-0.9	0.0	-0.1
Vertical activity count, locomotor time 1	0.6	1.4	1.9	1.4	1.2	1.1	1.1	-1.1
Time >=10cm from walls, locomotor time 2	0.4	0.6	0.8	-0.8	-0.9	-0.2	-0.8	0.8
Bouts of movement, locomotor time 2	2.2	3.5	4.0	1.7	1.9	1.8	2.0	-2.0
Total resting periods, locomotor time 2	2.2	3.8	4.4	1.8	2.0	1.9	2.1	-2.1
Rest time, locomotor task time 2	0.1	0.2	0.8	0.2	0.0	0.9	0.2	-0.1
Distance moved, locomotor task time 2	0.3	0.3	1.2	-0.4	-0.2	-1.1	-0.4	0.4
Vertical activity count, locomotor time 2	0.1	0.1	0.5	0.2	0.2	0.7	0.3	-0.3
Light reinforcement 1	2.0	4.8	6.8	-2.6	-2.3	-1.8	-2.1	2.1
Light reinforcement 2	0.6	0.9	1.2	-1.1	-1.1	-0.4	-1.0	1.0
Bone: marrow area	7.7	16.8	18.1	4.0	4.3	4.0	4.1	-4.1
Bone: maximum diameter	4.6	8.6	9.0	2.9	2.8	3.0	3.0	-2.9
Bone: maximum force	15.6	27.6	30.4	5.3	5.5	5.0	5.2	-5.2
Bone: maximum moment	16.3	28.5	32.1	5.4	5.7	5.1	5.2	-5.3
Mean time between licks in bursts	0.1	0.4	0.7	-0.6	-0.4	-0.9	-0.6	0.5
Mean num. licks in bursts	0.0	0.1	0.1	0.3	0.2	-0.1	-0.3	0.4
Cd content in liver	0.7	0.8	1.1	-0.8	-1.0	-0.7	-1.0	1.0
Co content in liver	0.1	0.1	0.3	-0.2	-0.6	0.3	-0.1	0.2
Cu content in liver	1.5	1.8	2.1	1.4	1.1	1.5	1.3	-1.2
Fe content in liver	1.7	2.1	2.3	-1.4	-1.5	-1.5	-1.4	1.4
K content in liver	0.1	0.1	0.2	0.3	0.1	0.5	0.3	-0.2
Mg content in liver	0.0	0.0	0.1	-0.2	-0.3	-0.0	-0.2	0.3
Mn content in liver	0.0	0.0	0.1	-0.3	0.0	-0.2	-0.0	-0.0
Na content in liver	0.0	0.0	0.0	-0.2	-0.2	0.1	0.1	-0.0
Rb content in liver	0.0	0.0	0.0	0.1	-0.2	0.1	0.2	-0.1
Se content in liver	1.3	1.5	1.9	-1.2	-1.4	-1.0	-1.3	1.3
Sr content in liver	2.2	1.9	3.0	1.2	1.2	1.7	1.3	-1.3
Zn content in liver	0.7	0.8	1.1	-0.9	-1.0	-0.6	-0.8	0.9
Bone: minimum diameter	9.9	18.1	18.6	4.2	4.3	4.2	4.3	-4.3
Time in familiar zone, hab. session 1	0.3	0.3	0.4	-0.4	-0.4	-0.6	-0.6	0.6
Time in novel zone, hab. session 1	0.3	0.3	0.5	0.3	0.6	0.3	0.7	-0.7
Total zone transitions, hab. session 1	0.3	0.4	0.5	-0.7	-0.6	-0.7	-0.6	0.6
Total locomotion distance, hab. session 1	0.0	0.0	0.1	0.0	0.2	-0.3	-0.1	0.0
Locomotion velocity, hab. session 1	0.0	0.0	0.1	0.1	0.3	-0.0	0.1	-0.1
Time in familiar zone, hab. session 2	0.3	0.3	0.6	0.6	0.6	0.8	0.4	-0.4
Time in novel zone, hab. session 2	0.2	0.2	0.5	-0.7	-0.5	-0.6	-0.3	0.2
Total zone transitions, hab. session 2	0.2	0.3	0.4	-0.5	-0.5	-0.3	-0.6	0.7
Total locomotion distance, hab. session 2	0.1	0.1	0.2	-0.2	-0.1	-0.1	-0.4	0.4
Locomotion velocity, hab. session 2	0.0	0.0	0.1	-0.1	-0.0	0.1	-0.3	0.3
Novel to familiar place preference ratio	1.6	1.8	2.5	1.2	1.2	1.0	1.5	-1.6
Novelty place preference	1.2	1.3	1.9	1.0	1.1	0.8	1.3	-1.4
Time in novel zone, NPP test	1.0	1.0	1.6	0.9	1.0	0.7	1.2	-1.3
Total zone transitions, NPP test	1.1	1.5	2.1	-1.2	-1.4	-0.7	-1.4	1.4
Total locomotion distance, NPP test	1.6	2.1	2.6	-1.5	-1.4	-1.2	-1.6	1.6
Locomotion velocity, NPP test	0.8	1.1	1.5	-1.0	-1.0	-0.8	-1.2	1.2
Intraocular pressure	7.2	10.4	11.4	-3.3	-3.1	-3.4	-3.2	3.1
Delta distance traveled before/after self-admin	0.1	0.1	0.4	0.2	0.1	0.6	-0.1	0.2
Delta ambulatory time before/after self-admin	0.0	0.1	0.1	-0.0	-0.1	0.4	-0.2	0.3
Parametrial fat weight	0.8	1.9	2.6	-1.4	-1.6	-0.9	-1.4	1.4
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.0	0.5	-0.3	0.1	-0.2
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.0	-0.2	0.4	-0.3	0.3
Pavlov. Cond. change in total contacts	0.1	0.1	0.4	0.3	0.0	0.6	0.3	-0.2
Pavlov. Cond. index score	0.2	0.2	0.9	0.3	-0.0	0.9	0.3	-0.2
Pavlov. Cond. latency score	0.2	0.2	0.8	0.3	-0.1	0.9	0.3	-0.1
Pavlov. Cond. lever contacts	0.3	0.3	0.7	-0.5	-0.9	-0.1	-0.5	0.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	-0.1	0.1	-0.6	0.0	-0.1
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.9	-0.6	-0.6	-0.9	-0.7	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.4	0.6	0.2	1.2	0.6	-0.4
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.2	-0.5	0.2	-0.4	0.4
Pavlov. Cond. lever latency	0.1	0.1	0.1	0.2	0.4	-0.1	0.3	-0.3
Pavlov. Cond. magazine entry latency	1.1	1.3	1.5	1.1	1.2	1.2	1.1	-1.1
Pavlov. Cond. change in total contacts	1.8	2.8	3.9	1.8	1.4	2.0	1.6	-1.5
Pavlov. Cond. index score	0.7	1.0	1.4	1.0	0.9	1.2	0.9	-0.9
Pavlov. Cond. latency score	0.7	0.9	1.3	1.0	0.8	1.2	0.9	-0.9
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.0	-0.2	0.3	-0.1	0.2
Pavlov. Cond. magazine entry number	2.6	3.2	3.3	-1.8	-1.8	-1.8	-1.8	1.8
Pavlov. Cond. intertrial magazine entries	5.9	8.8	9.1	-2.8	-3.0	-3.0	-3.0	3.0
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.4	1.8	1.2	1.1	1.3	1.1	-1.1
Pavlov. Cond. response bias	0.1	0.1	0.3	0.4	0.2	0.5	0.3	-0.2
Time in closed arm before self-admin	2.4	3.0	3.3	1.6	1.7	1.7	1.8	-1.8
Time in closed arm after self-admin	0.2	0.2	0.5	0.3	0.4	0.7	0.3	-0.3
Time in open arm before self-admin	0.1	0.1	0.4	-0.2	-0.1	-0.6	-0.1	0.1
Time in open arm after self-admin	0.1	0.1	0.4	-0.2	-0.2	-0.6	-0.1	0.1
Bone: periosteal estimation	13.6	28.6	29.0	5.3	5.4	5.3	5.4	-5.3
Bone: periosteal perimeter	11.6	19.9	21.3	4.6	4.5	4.5	4.4	-4.3
Bone: post-yield work	8.8	12.8	13.9	3.4	3.7	3.5	3.6	-3.7
Progressive ratio test 1 active lever presses	4.8	5.9	7.7	-2.6	-2.8	-2.2	-2.2	2.3
Progressive ratio test 1 breakpoint	4.4	5.4	7.0	-2.5	-2.7	-2.0	-2.1	2.2
Progressive ratio test 1 inactive lever presses	1.9	2.7	3.3	-1.8	-1.8	-1.6	-1.5	1.5
Progressive ratio test 2 active lever presses	1.7	2.0	2.5	-1.6	-1.5	-1.5	-1.2	1.2
Progressive ratio test 2 breakpoint	1.6	1.8	2.4	-1.5	-1.4	-1.5	-1.1	1.1
Progressive ratio test 2 inactive lever presses	1.1	1.9	2.7	-1.5	-1.3	-1.6	-1.2	1.2
Incentive Sensitization - Responses	0.2	0.3	0.4	0.4	0.6	0.3	0.6	-0.5
Incentive Sensitization - Breakpoint	0.1	0.2	0.3	0.3	0.5	0.2	0.5	-0.5
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.0	0.2	0.0	0.0	-0.0
Progressive ratio	0.2	0.3	0.4	-0.4	-0.5	-0.2	-0.6	0.6
Food seeking constrained by brief footshock	0.6	0.7	1.1	-0.9	-1.1	-0.1	-0.8	0.9
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	-0.1	-0.2	0.0	0.0	-0.0
Retroperitoneal fat weight	0.3	1.1	1.5	-1.0	-1.2	-0.9	-1.1	1.1
Reaction time number correct	0.9	1.7	2.5	1.2	1.6	1.3	1.2	-1.3
Reaction time mean minus median	4.9	12.3	14.3	-3.2	-3.4	-3.8	-3.5	3.6
Reaction time mean minus median AUC	3.5	8.9	11.5	-2.7	-2.8	-3.4	-3.0	3.0
Reaction time num false alarms	1.9	2.6	3.9	-1.4	-1.4	-2.0	-1.6	1.6
Reaction time num false alarms AUC	2.6	4.0	6.1	-1.7	-1.7	-2.5	-2.0	2.0
Reaction time trials correct on left	0.9	1.7	2.5	1.2	1.6	1.3	1.2	-1.3
Reaction time trials on left	0.7	1.3	1.9	1.1	1.4	1.1	1.0	-1.1
Reaction time mean	0.6	1.0	1.3	-0.8	-1.0	-1.2	-0.9	1.0
Reaction time mean AUC	0.3	0.5	0.9	-0.5	-0.7	-1.0	-0.7	0.8
Median of all reaction times	0.0	0.0	0.0	0.2	0.1	0.0	0.2	-0.1
Reaction time omissions	9.9	14.5	15.5	-3.7	-3.8	-3.7	-3.9	3.9
Reaction time false alarm rate	2.9	4.1	5.7	-1.7	-1.9	-2.4	-2.0	2.0
Reaction time premature initiation rate	4.8	6.6	8.2	-2.7	-2.9	-2.0	-2.5	2.6
Reaction time premature initiations	1.8	3.1	3.8	-2.0	-1.9	-1.3	-1.8	1.8
Std. dev. reaction times	5.2	9.6	11.7	-2.8	-3.0	-3.4	-3.1	3.1
Reaction time trials completed	0.7	1.3	1.9	1.1	1.4	1.1	1.0	-1.1
Reaction time trials AUC	1.2	2.2	3.1	1.4	1.8	1.5	1.3	-1.4
Run reversals in cocaine runway, females	0.0	0.0	0.2	-0.0	0.1	-0.4	-0.0	-0.1
Run reversals in cocaine runway, males	1.1	1.1	1.3	-1.2	-1.1	-0.8	-1.1	1.1
Latency to leave start box in cocaine runway	0.1	0.1	0.3	-0.2	-0.1	-0.6	-0.1	0.1
Latency to leave start box in cocaine runway, F	1.2	1.4	2.4	-1.3	-1.0	-1.5	-1.0	1.0
Latency to leave start box in cocaine runway, M	1.8	1.6	2.0	1.4	1.3	1.2	1.2	-1.2
Std. dev. time between licks in bursts	0.7	0.9	1.3	-1.1	-1.1	-0.6	-0.9	0.9
Total sessions with >9 infusions	1.7	2.1	2.9	-1.4	-1.7	-1.4	-1.3	1.4
Short access day 1 total inactive lever presses	1.6	2.0	2.6	-1.4	-1.6	-1.3	-1.4	1.4
Short access day 10 total inactive lever presses	0.1	0.2	0.3	-0.6	-0.4	-0.2	-0.4	0.4
Short access day 1 total infusions	0.6	0.8	1.6	-0.7	-1.0	-1.3	-0.7	0.8
Short access day 10 total infusions	1.1	1.5	2.2	-1.1	-1.5	-0.9	-1.1	1.2
Short access total infusions	2.1	2.7	3.6	-1.6	-1.9	-1.7	-1.5	1.6
Short access day 1 locomotion	0.1	0.1	0.3	-0.4	-0.6	-0.1	-0.1	0.2
Short access day 10 total locomotion	0.2	0.3	0.7	-0.8	-0.7	-0.4	-0.4	0.3
Short access total locomotion	0.7	0.9	1.4	-1.2	-1.1	-0.8	-0.7	0.7
One hour access (0.3 mA shock)	0.1	0.1	0.3	-0.2	-0.4	-0.5	-0.2	0.3
Compulsive drug intake	0.0	0.1	0.2	0.0	-0.0	-0.4	-0.2	0.2
One hour access (shock baseline)	0.0	0.0	0.0	0.1	-0.0	0.2	0.2	-0.1
Social response proportion	0.3	0.3	0.9	-0.3	-0.4	-1.0	-0.4	0.4
Social responses	8.1	10.5	13.7	-3.1	-3.2	-3.7	-3.1	3.1
Social time	0.0	0.1	0.1	0.3	0.0	-0.3	-0.2	0.2
Soleus weight	0.6	1.9	2.4	1.3	1.2	1.6	1.4	-1.3
Bone: stiffness	18.2	29.6	32.2	5.5	5.7	5.1	5.4	-5.5
Tibialis anterior weight	1.2	4.0	5.1	1.8	1.4	2.3	2.2	-2.1
Time to tail flick, vehicle, before self-admin	1.9	2.0	2.3	-1.4	-1.3	-1.5	-1.5	1.4
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.6	0.1	0.4	-0.7	0.4	-0.4
Time to tail flick, test, before self-admin	0.2	0.2	0.4	-0.6	-0.4	-0.1	-0.6	0.6
Time to tail flick, test, after self-admin	0.5	0.6	0.9	0.8	0.9	0.4	0.7	-0.7
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.7	0.8	0.7	0.4	0.8	-0.8
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	0.6	0.4	-0.3	0.6	-0.5
Tibia length	7.9	21.8	22.3	4.7	4.6	4.6	4.7	-4.7
Ambulatory time before self-admin	1.6	2.4	3.0	-1.7	-1.7	-1.4	-1.5	1.5
Ambulatory time after self-admin	1.0	1.2	1.4	-1.2	-1.2	-0.8	-1.1	1.1
Bone: tissue strength	0.9	0.9	1.2	0.8	1.1	0.8	0.9	-1.0
Total heroin consumption	1.0	1.2	1.7	0.8	1.0	1.3	1.2	-1.2
Bone: trabecular number	6.1	10.1	11.6	3.4	3.4	3.3	2.9	-2.9
Bone: trabecular spacing	2.3	3.1	3.8	-1.9	-1.8	-2.0	-1.5	1.5
Bone: trabecular thickness	0.0	0.1	0.1	-0.1	-0.3	-0.0	-0.3	0.3
Bone: trabecular tissue density	0.1	0.1	0.3	-0.4	-0.1	-0.5	-0.0	-0.1
Water consumed over 24 hours	0.1	0.1	0.1	0.4	0.4	0.3	0.2	-0.2
Number of responses in last shaping day	0.1	0.1	0.3	-0.4	-0.3	-0.6	0.0	-0.0