Rmdn3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Rmdn3	0.07	0.04	1.5e-06	0.06	0.06	0.06	0.06	1.9e-07	9.0e-07	9.6e-07	8.0e-07
2	Brain	gene expression	Rmdn3	0.08	0.04	5.1e-06	0.04	0.05	0.04	0.05	1.1e-04	2.5e-05	5.4e-05	4.1e-05
3	Adipose	gene expression	Rmdn3	0.37	0.11	0.0e+00	0.27	0.26	0.26	0.27	4.4e-30	4.8e-29	3.3e-29	1.2e-29
4	Liver	gene expression	Rmdn3	0.46	0.13	0.0e+00	0.31	0.3	0.31	0.31	4.3e-35	5.3e-34	7.8e-35	4.4e-35
5	Adipose	mRNA stability	Rmdn3	0.05	0.03	6.9e-04	0.03	0.02	0.03	0.03	9.8e-05	2.1e-03	4.4e-04	2.4e-04
6	NAcc	isoform ratio	XR_010064616.1	0.02	0.01	5.5e-03	0.01	0.01	0.01	0.01	1.2e-02	2.4e-03	4.3e-03	3.2e-03
7	NAcc	isoform ratio	NM_001014046.2	0.03	0.02	1.1e-03	0.01	0.02	0.02	0.02	8.6e-03	7.1e-04	3.3e-04	3.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.7	1.3	2.1	-1.0	-1.2	1.4	1.4	1.2	-0.5	0.5
Area under the delay curve	1.6	1.9	3.9	-0.9	-1.4	1.3	1.3	-0.0	-1.9	2.0
BMI with tail	3.9	13.5	20.5	-4.4	-4.5	3.4	3.4	3.2	-3.4	3.2
BMI without tail	6.2	18.9	27.4	-5.2	-5.1	4.5	4.5	4.5	-3.2	2.9
Body weight	4.4	19.2	28.6	-5.3	-5.4	3.9	3.9	3.8	-4.2	3.9
Weight adjusted by age	0.8	1.2	2.4	-1.3	-1.2	0.4	0.4	0.2	-1.5	1.5
Bone surface	0.7	1.2	2.1	-1.2	-1.3	1.2	1.2	1.5	-0.3	0.2
Bone volume	0.8	1.4	2.3	-1.2	-1.5	1.3	1.3	1.5	-0.5	0.3
Breakpoint value in progressive ratio session	0.3	0.4	1.1	0.7	0.4	-0.2	-0.2	-0.2	0.9	-1.0
Number of licking bursts	0.4	0.6	1.7	0.8	0.5	0.0	0.0	0.3	1.3	-1.2
Context. condit. distance diff. score	2.3	2.8	5.8	-1.8	-1.8	1.9	1.9	2.4	-0.3	0.1
Locomotion velocity, session 1	3.0	3.2	5.5	2.3	2.2	-1.6	-1.6	-2.3	1.1	-0.8
Locomotion distance, session 1	1.3	1.6	2.9	1.6	1.7	-1.0	-1.0	-1.6	0.8	-0.7
Locomotion velocity, session 2	0.6	0.7	1.5	-0.2	-0.6	1.2	1.2	0.0	-0.7	0.9
Locomotion distance, session 2	0.5	0.7	1.3	1.1	1.1	-0.3	-0.3	-0.6	1.0	-1.0
Locomotion velocity, session 3	0.2	0.2	0.4	0.7	-0.0	0.5	0.5	-0.6	-0.0	0.2
Locomotion distance, session 3	0.6	0.6	1.0	0.2	-0.3	0.9	0.9	0.9	1.0	-1.0
Stereotopy head waving bouts, day 3	2.5	2.9	5.3	-1.8	-2.0	1.1	1.1	0.5	-2.3	2.3
Stereotopy head waving duration, day 3	2.5	3.0	6.2	-1.4	-1.8	1.4	1.4	0.2	-2.3	2.5
Locomotion velocity, session 7	0.6	0.7	1.3	-0.6	-0.8	1.1	1.1	1.1	0.0	-0.1
Locomotion distance, session 7	0.4	0.5	1.5	-0.5	-0.2	0.5	0.5	1.2	0.8	-0.9
Stereotopy head waving bouts, day 7	0.2	0.3	0.7	0.3	0.2	-0.6	-0.6	-0.8	-0.3	0.4
Stereotopy head waving duration, day 7	0.3	0.4	0.7	-0.0	-0.1	-0.7	-0.7	-0.8	-0.6	0.7
Locomotion velocity, session 8	2.0	2.4	4.3	-1.2	-1.6	2.1	2.1	1.1	-1.2	1.3
Locomotion distance, session 8	0.8	1.2	2.5	-0.8	-0.8	1.5	1.5	1.6	0.3	-0.5
Degree of sensitization distance	0.4	0.4	1.1	-0.2	0.4	-1.1	-1.1	-0.1	0.0	-0.1
Degree of sensitization stereotypy	0.3	0.3	1.0	0.2	0.4	-1.0	-1.0	-0.4	0.2	-0.2
Conditioned locomotion	2.0	2.3	3.4	-1.8	-1.7	1.7	1.7	1.8	-0.8	0.8
Cocaine response after cond. corrected	1.0	1.3	2.7	1.5	0.9	0.4	0.4	-0.3	1.7	-1.5
Cocaine response after cond. not corrected	1.4	1.6	3.6	1.9	1.3	0.2	0.2	-0.7	1.7	-1.6
Cocaine response before conditioning	0.3	0.3	0.7	0.5	0.6	-0.6	-0.6	-0.8	-0.3	0.3
Saline control response	1.6	2.2	4.5	-1.9	-1.6	0.2	0.2	0.5	-2.1	2.0
Bone: connectivity density	0.2	0.4	0.9	-0.8	-0.6	0.0	0.0	0.1	-1.0	0.9
Bone: cortical apparent density	0.9	1.2	2.3	0.5	0.8	-1.3	-1.3	0.1	1.3	-1.5
Bone: cortical area	1.3	2.0	3.2	-1.5	-1.8	1.4	1.4	1.1	-1.4	1.3
Bone: cortical porosity	0.7	0.8	2.2	1.5	0.8	0.8	0.8	-0.6	0.8	-0.5
Bone: cortical porosity	0.4	0.4	1.1	0.6	0.1	1.1	1.1	-0.2	0.0	0.2
Bone: cortical thickness	0.9	1.4	2.0	-1.1	-1.4	1.2	1.2	0.7	-1.2	1.3
Bone: cortical thickness	0.3	0.3	0.7	0.4	-0.1	0.6	0.6	0.5	0.8	-0.8
Bone: cortical tissue density	0.9	1.2	2.2	0.5	0.8	-1.3	-1.3	0.0	1.3	-1.5
Condit. Reinf. active minus inactive responses	0.9	1.0	3.1	-0.3	0.5	-1.7	-1.7	-0.5	-0.4	0.3
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.1	-1.0	-0.7	-0.3	-0.3	0.3	-1.0	0.9
Condit. Reinf. active responses	1.8	2.3	6.9	0.1	1.1	-2.6	-2.6	-0.9	0.1	-0.3
Condit. Reinf. inactive responses	1.6	2.0	4.2	0.8	1.4	-2.1	-2.1	-0.7	1.0	-1.2
Incentive salience index mean	2.0	2.4	6.6	0.4	1.3	-2.6	-2.6	-1.3	0.0	-0.1
Condit. Reinf. lever presses	1.9	2.7	6.7	0.7	1.6	-2.6	-2.6	-1.5	0.1	-0.2
Condit. Reinf. active minus inactive responses	0.5	0.7	2.4	-1.5	-0.9	-0.2	-0.2	0.9	-0.8	0.4
Condit. Reinf. active-inactive response ratio	0.4	0.5	1.6	-1.3	-0.8	-0.0	-0.0	0.9	-0.5	0.2
Condit. Reinf. active responses	0.9	1.2	3.8	-1.9	-1.2	-0.3	-0.3	1.0	-1.2	0.8
Condit. Reinf. inactive responses	0.7	0.9	2.0	-1.2	-0.8	-0.7	-0.7	-0.0	-1.4	1.2
Condit. Reinf. lever presses	1.3	1.8	3.9	-1.7	-1.1	-0.9	-0.9	-0.2	-2.0	1.8
Condit. Reinf. lever reinforcers received	0.9	1.2	3.4	-1.8	-1.0	-0.7	-0.7	0.6	-1.3	1.0
Conditioned reinforcement - actives	0.1	0.2	0.6	0.6	0.6	-0.3	-0.3	-0.8	0.1	-0.1
Conditioned reinforcement - inactives	0.3	0.4	0.8	-0.3	-0.3	0.9	0.9	0.9	0.4	-0.5
Conditioned locomotion	0.7	0.9	2.0	0.2	0.3	-0.8	-0.8	-1.4	-1.1	1.2
Patch foraging indifference point 0 sec	2.5	4.6	11.9	-2.1	-1.7	-0.2	-0.2	-0.9	-3.4	3.5
Patch foraging indifference point AUC	1.4	2.0	2.6	1.5	1.6	-1.4	-1.4	-1.5	1.2	-1.2
Delay disc. indifference point, 0s delay	0.9	1.0	2.4	-0.1	-0.1	-0.6	-0.6	-1.2	-1.4	1.5
Delay disc. indifference point, 16s delay	0.3	0.4	0.9	0.2	-0.4	0.6	0.6	-0.6	-0.7	0.9
Delay disc. indifference point, 2s delay	0.9	1.0	2.2	-1.5	-1.2	0.6	0.6	0.9	-1.1	0.9
Delay disc. indifference point, 24s delay	1.0	1.1	2.6	1.3	1.2	-1.1	-1.1	-1.6	0.1	-0.1
Delay disc. indifference point, 4s delay	0.7	0.7	1.4	-0.5	-0.7	0.9	0.9	-0.0	-1.1	1.2
Delay disc. indifference point, 8s delay	3.2	3.8	7.1	-1.5	-2.1	1.8	1.8	0.3	-2.5	2.7
Indifference point function ln k	2.8	5.0	7.3	-2.2	-2.5	2.7	2.7	2.5	-1.2	1.2
Indifference point function log k	2.8	5.0	7.3	-2.2	-2.5	2.7	2.7	2.5	-1.2	1.2
Patch foraging total patch changes 0 sec	2.1	3.9	10.1	-1.9	-1.7	-0.3	-0.3	-0.9	-3.1	3.2
Patch foraging total patch changes 12 sec	0.9	1.2	1.9	-0.3	0.1	-1.4	-1.4	-1.4	-1.2	1.1
Patch foraging total patch changes 18 sec	0.5	0.7	1.6	0.3	0.6	-1.2	-1.2	-1.3	-0.2	0.0
Patch foraging total patch changes 24 sec	0.8	1.4	3.4	-1.2	-1.2	0.5	0.5	-0.3	-1.9	1.8
Patch foraging total patch changes 6 sec	0.5	0.8	1.7	-0.3	0.0	-1.0	-1.0	-1.3	-0.9	0.9
Patch foraging time to switch 0 sec	0.8	1.6	4.1	0.3	0.9	-2.0	-2.0	-1.3	-0.4	0.4
Patch foraging water rate 0 sec	0.8	1.6	2.8	-1.3	-1.5	1.5	1.5	1.7	-0.2	0.1
Patch foraging water rate 12 sec	0.8	1.7	2.7	0.1	-0.4	1.5	1.5	1.6	1.5	-1.6
Patch foraging water rate 18 sec	0.7	1.2	3.0	-0.1	-0.8	1.7	1.7	1.1	0.3	-0.3
Patch foraging water rate 24 sec	1.0	1.4	3.6	-1.0	-1.2	1.3	1.3	1.9	0.6	-0.7
Patch foraging water rate 6 sec	1.1	1.6	4.8	0.8	0.6	0.3	0.3	0.9	2.2	-2.2
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	2.1	-0.7	-0.6	0.6	0.6	1.4	0.4	-0.7
Distance traveled before self-admin	0.3	0.4	0.8	-0.6	-0.8	0.9	0.9	0.3	-0.5	0.4
Distance traveled after self-admin	0.0	0.0	0.1	-0.2	-0.2	0.1	0.1	0.1	0.2	-0.3
Extensor digitorum longus weight	0.2	0.8	1.4	-0.5	-1.1	1.2	1.2	0.6	-0.5	0.6
Bone: elastic displacement	0.2	0.2	0.5	0.2	0.1	-0.3	-0.3	-0.7	-0.5	0.6
Bone: elastic work	0.5	0.7	1.5	-0.9	-0.9	0.1	0.1	-0.0	-1.2	1.2
Bone: endosteal estimation	0.3	0.7	1.3	-0.3	-0.5	1.1	1.1	1.2	0.6	-0.7
Bone: endosteal perimeter	0.1	0.2	0.4	-0.2	-0.3	0.6	0.6	0.6	0.3	-0.3
Epididymis fat weight	0.4	1.3	2.6	-0.6	-1.1	1.6	1.6	0.5	-0.9	1.1
Delta time in closed arm before/after self-admin	0.3	0.3	0.7	-0.3	-0.1	0.4	0.4	0.9	0.5	-0.6
Delta time in open arm before/after self-admin	1.9	1.9	4.7	-1.3	-1.4	1.6	1.6	2.2	0.3	-0.5
Diff in mean of infusions in LGA sessions	0.4	0.5	1.3	0.1	0.4	-1.1	-1.1	-0.7	-0.3	0.1
Delay discount exponential model param	1.3	1.4	2.8	0.7	1.2	-1.2	-1.2	-0.0	1.6	-1.7
Extinction: sum of active levers before priming	0.9	0.9	1.8	1.3	1.2	-0.7	-0.7	-1.3	0.6	-0.5
Active lever presses in extinction session 6	0.3	0.3	1.0	0.8	0.6	-0.1	-0.1	-1.0	0.2	-0.1
Bone: final force	0.9	1.4	2.8	-1.6	-1.5	1.0	1.0	1.7	-0.6	0.4
Bone: final moment	0.8	1.3	2.6	-1.5	-1.4	1.0	1.0	1.6	-0.6	0.4
Food consumed during 24 hour testing period	0.4	0.6	1.4	0.7	0.5	0.3	0.3	0.3	1.2	-1.2
Glucose	1.6	2.4	4.0	-1.5	-1.8	1.9	1.9	2.0	-0.4	0.2
Heart weight	3.1	4.7	6.6	-2.5	-2.6	2.2	2.2	2.3	-1.7	1.5
Delay discount hyperbolic model param	1.4	1.5	2.8	0.9	1.3	-1.2	-1.2	-0.2	1.6	-1.7
Intermittent access intake day 1-15 change	1.0	2.0	4.2	-0.5	-0.9	1.8	1.8	2.0	1.0	-1.1
Intermittent access intake escalation	0.9	2.0	4.1	-0.8	-1.2	1.8	1.8	2.0	0.6	-0.8
Intermittent access intake escalation 2	2.2	2.5	3.8	0.4	-0.2	1.9	1.9	1.6	1.8	-2.0
Intermitt. access day 1 inactive lever presses	0.4	1.4	2.4	-1.6	-1.2	0.7	0.7	0.9	-1.5	1.6
Intermitt. access day 15 inactive lever presses	0.4	0.8	1.8	-0.9	-0.9	1.0	1.0	1.3	-0.1	0.1
Intermitt. access escalation Index	0.3	0.5	1.3	-1.1	-0.8	-0.4	-0.4	0.5	-0.8	0.5
Intermittent access day 1 total infusions	0.2	0.4	1.1	0.3	0.3	-0.6	-0.6	-1.1	-0.5	0.6
Intermittent access day 15 total infusions	0.4	0.5	1.0	-0.7	-0.9	0.8	0.8	1.0	-0.2	0.0
Intermittent access terminal intake (last 3 days)	0.7	0.9	1.6	-0.3	-0.7	1.3	1.3	1.3	0.5	-0.6
Intermittent access total infusions	0.1	0.1	0.1	-0.2	-0.4	0.3	0.3	0.3	-0.1	0.1
Intermittent access day 1 locomotion	0.8	1.0	3.3	-0.5	-0.6	0.0	0.0	-0.7	-1.7	1.8
Intermittent access day 15 total locomotion	0.7	1.2	2.5	-0.8	-1.0	1.5	1.5	1.6	0.0	-0.1
Intermittent access total locomotion	0.2	0.2	0.3	-0.3	-0.4	0.5	0.5	0.2	-0.5	0.5
Intermittent access standard deviation	0.6	1.2	2.1	-0.1	-0.5	1.4	1.4	1.4	1.0	-1.0
Left kidney weight	2.5	11.5	14.8	-3.6	-3.7	3.8	3.8	3.0	-2.8	2.7
Right kidney weight	3.7	17.0	20.5	-4.5	-4.5	4.4	4.4	3.2	-3.9	3.8
Cocaine induced anxiety	0.8	1.1	2.8	-1.1	-0.8	0.5	0.5	0.1	-1.6	1.7
Post-drug Anxiety	1.3	1.3	2.4	-1.5	-1.1	1.0	1.0	1.1	-1.2	1.2
Baseline Anxiety	0.2	0.2	0.7	-0.4	-0.2	0.2	0.2	0.8	0.4	-0.6
Tail length	2.1	8.2	12.6	-3.3	-3.2	3.1	3.1	3.5	-1.5	1.2
Length with tail	1.1	4.9	7.8	-2.8	-2.7	2.0	2.0	2.2	-1.9	1.7
Length without tail	0.4	1.3	2.2	-1.2	-1.5	1.2	1.2	1.0	-1.1	1.0
Times rat made contact with spout	0.1	0.2	0.4	0.0	-0.2	-0.3	-0.3	-0.5	-0.6	0.5
Lifetime Intake	0.0	0.0	0.0	0.2	-0.1	0.1	0.1	-0.2	-0.1	0.2
Liver weight, left	2.8	4.6	8.5	-2.9	-2.6	1.6	1.6	2.1	-2.0	1.9
Liver weight, right	1.9	3.3	5.1	-2.1	-2.3	1.4	1.4	1.1	-2.1	2.0
Locomotor activity	0.3	0.4	0.9	0.9	0.9	-0.6	-0.6	-0.8	0.2	-0.0
Locomotor testing distance	0.3	0.5	0.9	1.0	0.9	-0.7	-0.7	-0.8	0.3	-0.1
Locomotor testing rearing	0.9	1.9	2.9	1.5	1.7	-1.4	-1.4	-0.9	1.3	-1.2
Locomotion in novel chamber	0.2	0.2	0.5	-0.5	-0.6	0.2	0.2	0.1	-0.6	0.7
Locomotion in novel chamber post-restriction	1.4	2.3	3.8	-1.6	-1.7	1.8	1.8	1.9	-0.6	0.4
Fecal boli incidents, locomotor time 1	0.4	0.6	1.8	1.3	0.9	-0.4	-0.4	-0.8	0.6	-0.4
Change in fecal boli incidents, locomotor task	2.2	2.2	3.3	-1.8	-1.7	1.6	1.6	1.7	-0.8	0.7
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.6	0.1	0.1	0.2	0.2	0.5	0.7	-0.8
Bouts of movement, locomotor time 1	4.3	4.8	7.8	2.8	2.6	-1.9	-1.9	-2.4	1.8	-1.6
Total resting periods, locomotor time 1	4.4	4.9	7.0	2.6	2.6	-2.1	-2.1	-2.4	1.8	-1.6
Rest time, locomotor task time 1	0.1	0.2	0.4	-0.0	0.4	-0.6	-0.6	-0.5	0.1	-0.0
Distance moved, locomotor task time 1	0.1	0.1	0.3	0.0	0.1	-0.5	-0.5	-0.5	-0.2	0.2
Vertical activity count, locomotor time 1	0.0	0.1	0.2	-0.4	-0.4	0.2	0.2	0.4	-0.0	-0.0
Time >=10cm from walls, locomotor time 2	5.2	7.6	12.7	-3.6	-3.3	2.0	2.0	2.2	-3.0	2.9
Bouts of movement, locomotor time 2	0.0	0.0	0.1	-0.0	-0.2	-0.3	-0.3	0.0	-0.0	-0.1
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.0	-0.2	-0.4	-0.4	-0.0	0.1	-0.1
Rest time, locomotor task time 2	3.2	4.0	6.3	2.3	2.5	-1.7	-1.7	-1.7	2.0	-1.9
Distance moved, locomotor task time 2	1.8	2.1	3.7	-1.9	-1.7	0.7	0.7	0.6	-1.9	1.9
Vertical activity count, locomotor time 2	2.2	3.1	5.8	-2.4	-2.3	1.2	1.2	1.5	-1.8	1.6
Light reinforcement 1	1.6	3.9	7.7	-1.5	-0.7	-2.1	-2.1	-1.3	-2.8	2.5
Light reinforcement 2	1.4	2.2	4.1	1.2	1.5	-2.0	-2.0	-1.6	0.6	-0.6
Bone: marrow area	0.3	0.7	1.3	-0.3	-0.6	1.1	1.1	1.1	0.5	-0.6
Bone: maximum diameter	0.7	1.2	2.1	-1.4	-1.5	1.0	1.0	1.1	-0.9	0.8
Bone: maximum force	1.5	2.6	4.3	-2.1	-2.0	1.4	1.4	1.6	-1.4	1.3
Bone: maximum moment	1.3	2.3	3.6	-1.9	-1.8	1.3	1.3	1.5	-1.3	1.2
Mean time between licks in bursts	0.3	0.7	1.5	1.2	1.1	-0.0	-0.0	-0.6	1.1	-0.8
Mean num. licks in bursts	0.5	0.8	2.3	-0.9	-0.7	-0.1	-0.1	-0.3	-1.5	1.4
Cd content in liver	0.3	0.3	0.5	-0.7	-0.7	0.5	0.5	0.5	-0.5	0.5
Co content in liver	0.2	0.2	0.6	0.5	-0.1	0.8	0.8	-0.3	-0.0	0.2
Cu content in liver	0.6	0.7	2.0	0.5	0.4	0.3	0.3	0.6	1.3	-1.4
Fe content in liver	1.9	2.3	5.0	0.6	1.4	-2.2	-2.2	-0.4	1.3	-1.5
K content in liver	0.5	0.4	0.9	-0.4	-0.5	0.9	0.9	1.0	0.3	-0.4
Mg content in liver	1.6	1.7	3.3	-0.8	-1.2	1.7	1.7	1.8	0.4	-0.6
Mn content in liver	1.7	1.8	2.9	-1.7	-1.6	1.1	1.1	1.0	-1.4	1.3
Na content in liver	0.5	0.6	1.3	0.7	0.9	-0.4	-0.4	0.2	1.2	-1.0
Rb content in liver	3.7	4.3	6.6	-2.0	-2.4	2.6	2.6	1.8	-1.4	1.4
Se content in liver	0.2	0.2	0.5	-0.6	-0.5	0.3	0.3	0.7	0.0	-0.2
Sr content in liver	0.2	0.1	0.4	0.6	0.5	-0.1	-0.1	-0.6	0.1	0.1
Zn content in liver	1.0	1.1	3.6	0.4	0.6	-0.2	-0.2	0.8	1.6	-1.9
Bone: minimum diameter	1.3	2.3	3.2	-1.1	-1.6	1.7	1.7	0.5	-1.7	1.8
Time in familiar zone, hab. session 1	1.8	1.7	2.9	1.7	1.5	-0.9	-0.9	-1.0	1.5	-1.4
Time in novel zone, hab. session 1	2.6	2.6	4.6	-2.1	-1.9	1.1	1.1	1.4	-1.7	1.6
Total zone transitions, hab. session 1	0.6	0.9	1.7	1.2	1.2	-0.8	-0.8	-1.3	0.5	-0.4
Total locomotion distance, hab. session 1	0.5	0.7	1.6	1.0	1.1	-0.8	-0.8	-1.3	0.3	-0.1
Locomotion velocity, hab. session 1	1.0	1.4	3.0	1.3	1.5	-1.2	-1.2	-1.7	0.3	-0.1
Time in familiar zone, hab. session 2	0.0	0.0	0.1	0.0	-0.1	-0.2	-0.2	-0.0	0.1	-0.1
Time in novel zone, hab. session 2	0.6	0.6	0.7	-0.8	-0.7	0.8	0.8	0.4	-0.8	0.8
Total zone transitions, hab. session 2	0.3	0.4	0.8	0.9	0.8	-0.0	-0.0	-0.4	0.7	-0.6
Total locomotion distance, hab. session 2	0.1	0.1	0.1	0.1	0.4	-0.4	-0.4	-0.3	-0.0	-0.0
Locomotion velocity, hab. session 2	0.2	0.2	0.4	0.3	0.6	-0.7	-0.7	-0.6	0.0	-0.0
Novel to familiar place preference ratio	1.4	1.5	2.8	-1.6	-1.4	0.3	0.3	0.6	-1.7	1.6
Novelty place preference	1.3	1.4	2.6	-1.6	-1.3	0.4	0.4	0.5	-1.6	1.6
Time in novel zone, NPP test	1.3	1.4	2.5	-1.6	-1.3	0.4	0.4	0.6	-1.5	1.5
Total zone transitions, NPP test	1.2	1.7	3.4	1.8	1.5	0.1	0.1	-0.7	1.8	-1.6
Total locomotion distance, NPP test	0.3	0.5	1.0	1.0	0.8	0.5	0.5	-0.3	0.8	-0.6
Locomotion velocity, NPP test	0.4	0.5	1.2	1.1	0.9	0.5	0.5	-0.5	0.8	-0.6
Intraocular pressure	1.3	1.9	4.2	1.6	1.3	-1.5	-1.5	-2.0	0.3	-0.1
Delta distance traveled before/after self-admin	0.2	0.2	0.6	0.3	0.5	-0.8	-0.8	-0.4	0.2	-0.1
Delta ambulatory time before/after self-admin	0.6	0.7	1.7	0.4	0.8	-1.3	-1.3	-0.8	0.1	-0.0
Parametrial fat weight	0.2	0.5	1.0	-0.3	0.1	-0.7	-0.7	-0.8	-1.0	1.0
Pavlov. Cond. lever latency	0.4	0.5	0.9	-0.6	-0.9	0.8	0.8	0.9	0.1	-0.1
Pavlov. Cond. magazine entry latency	0.9	1.1	1.9	-0.9	-0.1	-1.2	-1.2	-0.4	-1.4	1.3
Pavlov. Cond. change in total contacts	0.1	0.1	0.5	-0.3	0.1	0.0	0.0	0.7	0.2	-0.4
Pavlov. Cond. index score	0.6	0.8	1.8	0.2	0.8	-1.3	-1.3	-1.0	-0.5	0.5
Pavlov. Cond. latency score	0.7	0.9	1.7	0.2	0.7	-1.3	-1.3	-1.1	-0.8	0.8
Pavlov. Cond. lever contacts	0.5	0.7	1.1	0.6	1.0	-1.1	-1.1	-0.9	-0.1	0.1
Pavlov. Cond. magazine entry number	0.6	0.8	1.6	1.0	0.3	0.8	0.8	0.1	1.3	-1.2
Pavlov. Cond. intertrial magazine entries	0.5	0.6	2.0	0.5	0.1	0.2	0.2	0.6	1.3	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.4	0.5	0.9	-1.2	-1.2	-0.9	-0.2	0.2
Pavlov. Cond. response bias	0.3	0.4	1.1	0.0	0.6	-1.1	-1.1	-0.3	-0.1	0.0
Pavlov. Cond. lever latency	2.2	3.0	6.2	2.5	2.0	0.1	0.1	-0.7	2.4	-2.2
Pavlov. Cond. magazine entry latency	1.1	1.3	2.8	-1.7	-0.9	-1.0	-1.0	0.3	-1.3	1.1
Pavlov. Cond. change in total contacts	0.7	1.1	3.2	-1.8	-1.0	-0.7	-0.7	0.9	-1.1	0.8
Pavlov. Cond. index score	1.4	1.9	5.0	-2.2	-1.5	-0.7	-0.7	0.9	-1.6	1.3
Pavlov. Cond. latency score	1.1	1.5	4.1	-2.0	-1.3	-0.5	-0.5	0.9	-1.4	1.1
Pavlov. Cond. lever contacts	2.4	3.3	6.8	-2.6	-2.0	-0.3	-0.3	0.7	-2.5	2.3
Pavlov. Cond. magazine entry number	0.9	1.1	3.2	1.8	1.0	0.6	0.6	-0.8	1.1	-0.8
Pavlov. Cond. intertrial magazine entries	0.2	0.4	1.0	0.6	-0.1	1.0	1.0	-0.3	-0.1	0.3
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.7	4.6	-2.1	-1.4	-0.7	-0.7	0.8	-1.5	1.3
Pavlov. Cond. response bias	2.6	3.5	8.1	-2.8	-2.1	-0.5	-0.5	0.9	-2.4	2.1
Time in closed arm before self-admin	2.2	2.8	4.6	1.7	1.9	-2.1	-2.1	-1.6	1.0	-0.9
Time in closed arm after self-admin	1.4	1.5	2.8	0.9	1.3	-1.7	-1.7	-0.7	0.9	-1.0
Time in open arm before self-admin	0.4	0.4	1.1	-0.4	-0.7	0.4	0.4	-0.2	-1.0	1.0
Time in open arm after self-admin	2.9	3.2	5.9	-1.5	-1.9	2.4	2.4	2.1	-0.1	0.0
Bone: periosteal estimation	0.6	1.3	2.0	-1.0	-1.3	1.4	1.4	1.2	-0.6	0.5
Bone: periosteal perimeter	0.8	1.3	1.8	-1.0	-1.3	1.3	1.3	0.7	-1.1	1.2
Bone: post-yield work	0.3	0.5	0.8	0.3	0.2	0.9	0.9	0.7	0.9	-0.8
Progressive ratio test 1 active lever presses	0.1	0.2	0.4	0.2	0.2	-0.6	-0.6	-0.4	-0.1	0.1
Progressive ratio test 1 breakpoint	0.1	0.2	0.4	0.2	0.3	-0.6	-0.6	-0.4	-0.1	0.1
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	-0.0	0.2	-0.3	-0.3	0.1	0.1	-0.0
Progressive ratio test 2 active lever presses	0.0	0.1	0.1	-0.3	-0.2	-0.3	-0.3	0.1	-0.1	-0.0
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	-0.5	-0.4	-0.2	-0.2	0.3	-0.2	0.1
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.4	-0.6	-0.5	0.4	0.4	0.6	-0.3	0.1
Incentive Sensitization - Responses	0.0	0.0	0.1	-0.1	-0.3	0.2	0.2	0.1	-0.0	-0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	-0.2	-0.3	0.1	0.1	0.1	-0.1	0.0
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.5	0.5	0.4	0.5	0.5	0.4	1.2	-1.2
Progressive ratio	0.1	0.2	0.4	0.1	0.4	-0.7	-0.7	-0.2	0.3	-0.4
Food seeking constrained by brief footshock	0.0	0.0	0.1	-0.1	0.0	0.1	0.1	0.1	-0.1	0.3
Seeking ratio, punishment vs. effort	0.0	0.0	0.2	-0.0	-0.1	0.2	0.2	-0.0	-0.3	0.4
Retroperitoneal fat weight	2.4	10.2	18.7	-4.3	-3.8	1.2	1.2	1.7	-4.2	3.8
Reaction time number correct	2.4	4.5	8.4	-2.0	-2.3	2.7	2.7	2.9	-0.3	0.3
Reaction time mean minus median	0.3	0.7	1.0	-1.0	-1.0	0.4	0.4	0.6	-1.0	1.0
Reaction time mean minus median AUC	1.1	2.8	4.1	-2.0	-2.0	1.3	1.3	1.4	-1.8	1.7
Reaction time num false alarms	0.0	0.0	0.1	-0.3	-0.1	0.1	0.1	0.1	-0.2	0.3
Reaction time num false alarms AUC	0.0	0.0	0.1	-0.2	0.1	-0.2	-0.2	0.1	0.1	-0.0
Reaction time trials correct on left	2.4	4.5	8.4	-2.0	-2.3	2.7	2.7	2.9	-0.3	0.3
Reaction time trials on left	2.4	4.5	8.2	-2.0	-2.3	2.6	2.6	2.9	-0.3	0.4
Reaction time mean	0.5	0.8	2.0	0.4	0.7	-1.4	-1.4	-0.4	0.6	-0.7
Reaction time mean AUC	0.2	0.3	1.0	0.1	0.4	-1.0	-1.0	-0.2	0.3	-0.4
Median of all reaction times	1.6	2.2	4.1	1.1	1.5	-2.0	-2.0	-0.9	1.3	-1.3
Reaction time omissions	0.8	1.1	2.5	-1.5	-1.0	-0.1	-0.1	0.1	-1.6	1.5
Reaction time false alarm rate	0.8	1.0	2.0	0.7	1.1	-1.4	-1.4	-1.3	0.0	-0.0
Reaction time premature initiation rate	1.7	2.4	5.8	0.6	1.4	-2.4	-2.4	-1.6	-0.0	-0.2
Reaction time premature initiations	0.1	0.3	0.7	-0.5	0.1	-0.8	-0.8	0.1	-0.1	0.0
Std. dev. reaction times	0.4	0.8	1.6	-1.2	-1.1	-0.0	-0.0	0.4	-1.3	1.2
Reaction time trials completed	2.4	4.5	8.2	-2.0	-2.3	2.6	2.6	2.9	-0.3	0.4
Reaction time trials AUC	2.2	4.2	8.7	-2.0	-2.2	2.4	2.4	3.0	-0.2	0.2
Run reversals in cocaine runway, females	0.9	0.9	1.5	0.1	-0.1	1.2	1.2	1.1	1.0	-1.1
Run reversals in cocaine runway, males	0.3	0.3	0.6	0.5	0.7	-0.2	-0.2	-0.2	0.8	-0.8
Latency to leave start box in cocaine runway	0.1	0.1	0.2	-0.3	0.0	-0.4	-0.4	0.1	0.0	-0.0
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	0.6	0.6	-0.4	-0.4	-0.5	0.3	-0.2
Latency to leave start box in cocaine runway, M	0.9	0.8	2.8	-1.7	-0.9	-0.1	-0.1	1.3	-0.5	0.3
Std. dev. time between licks in bursts	0.8	1.1	2.0	-1.0	-1.2	0.9	0.9	0.2	-1.4	1.4
Total sessions with >9 infusions	0.8	1.0	3.0	0.8	0.6	-0.9	-0.9	-1.7	-0.7	0.8
Short access day 1 total inactive lever presses	0.8	1.0	2.0	-0.6	-0.9	1.4	1.4	0.5	-0.9	1.0
Short access day 10 total inactive lever presses	0.8	1.9	4.5	-1.4	-1.1	1.7	1.7	2.1	0.0	-0.0
Short access day 1 total infusions	0.4	0.5	1.7	1.0	0.7	-0.2	-0.2	-1.3	0.0	0.1
Short access day 10 total infusions	0.5	0.7	1.5	0.5	0.6	-1.1	-1.1	-1.2	-0.4	0.4
Short access total infusions	0.4	0.5	1.6	0.8	0.5	-0.7	-0.7	-1.3	-0.2	0.4
Short access day 1 locomotion	1.1	1.4	3.3	1.2	1.1	-1.3	-1.3	-1.8	-0.0	0.2
Short access day 10 total locomotion	0.5	0.9	2.3	-0.1	-0.8	1.5	1.5	0.0	-0.8	0.8
Short access total locomotion	0.8	0.9	2.8	-0.0	-0.2	-0.2	-0.2	-1.2	-1.5	1.7
One hour access (0.3 mA shock)	1.3	1.5	2.9	-0.1	-0.4	1.0	1.0	1.7	1.6	-1.7
Compulsive drug intake	0.8	0.9	1.8	0.1	-0.3	0.9	0.9	1.2	1.3	-1.2
One hour access (shock baseline)	0.1	0.1	0.3	-0.4	-0.1	-0.5	-0.5	-0.1	-0.4	0.2
Social response proportion	0.6	0.7	1.5	-1.2	-0.2	-1.1	-1.1	0.7	-0.2	-0.2
Social responses	1.4	1.8	5.4	0.0	0.8	-2.3	-2.3	-0.6	0.3	-0.6
Social time	0.1	0.1	0.3	-0.5	-0.3	-0.5	-0.5	0.4	-0.1	-0.0
Soleus weight	0.1	0.2	0.5	0.2	0.2	-0.7	-0.7	-0.0	0.5	-0.4
Bone: stiffness	0.9	1.5	2.8	-1.7	-1.4	0.9	0.9	1.3	-1.1	0.9
Tibialis anterior weight	0.1	0.3	0.9	-0.8	-0.6	-0.3	-0.3	1.0	0.1	-0.4
Time to tail flick, vehicle, before self-admin	0.2	0.3	0.9	-0.0	-0.3	0.1	0.1	-0.4	-0.8	0.9
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.7	-0.1	-0.7	0.8	0.8	0.6	0.0	0.1
Time to tail flick, test, before self-admin	0.2	0.3	0.5	0.1	0.1	-0.7	-0.7	-0.5	-0.5	0.5
Time to tail flick, test, after self-admin	0.5	0.5	1.0	-0.8	-0.9	0.3	0.3	0.1	-1.0	0.9
Delta time to tail flick, vehicle, before/after SA	1.9	1.8	3.9	-1.3	-1.4	1.5	1.5	2.0	0.0	-0.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	-0.3	-0.4	0.2	0.2	-0.1	-0.4	0.4
Tibia length	0.7	2.0	5.7	-1.3	-1.0	0.3	0.3	-0.4	-2.3	2.4
Ambulatory time before self-admin	0.3	0.5	0.8	-0.6	-0.9	0.8	0.8	0.0	-0.8	0.7
Ambulatory time after self-admin	0.1	0.1	0.2	0.1	0.2	-0.4	-0.4	-0.2	0.4	-0.4
Bone: tissue strength	0.3	0.3	0.8	-0.4	-0.4	0.9	0.9	0.4	-0.4	0.5
Total heroin consumption	0.5	0.5	1.5	1.2	0.9	0.1	0.1	-0.7	0.7	-0.6
Bone: trabecular number	1.7	2.7	5.1	-1.7	-1.8	2.0	2.0	2.3	-0.3	0.1
Bone: trabecular spacing	1.8	2.4	5.0	0.8	1.0	-2.1	-2.1	-2.2	-0.8	0.9
Bone: trabecular thickness	0.4	0.6	1.7	0.5	0.4	-0.0	-0.0	0.5	1.3	-1.3
Bone: trabecular tissue density	2.7	3.9	9.8	2.0	1.9	0.2	0.2	0.4	3.1	-3.1
Water consumed over 24 hours	0.6	0.7	1.4	0.7	0.7	-1.2	-1.2	-0.4	0.7	-0.8
Number of responses in last shaping day	0.9	0.9	2.2	0.6	0.8	-1.2	-1.2	-1.5	-0.4	0.5