Hub : Genes

Rinl

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain intron excision ratio chr1_84086426_84086850 0.03 0.03 1.6e-03 0.01 0.02 0.03 0.02 2.3e-02 6.7e-03 4.9e-04 7.6e-03
2 Liver mRNA stability Rinl 0.1 0.06 1.1e-10 0.04 0.06 0.06 0.07 1.6e-05 1.9e-07 1.0e-07 6.6e-08
3 Brain gene expression Rinl 0.03 0.02 2.7e-03 0.03 0.01 0.02 0.02 2.1e-03 1.7e-02 1.2e-02 5.3e-03
4 Liver gene expression Rinl 0.19 0.11 0.0e+00 0.11 0.12 0.12 0.12 1.3e-12 5.6e-13 7.6e-13 8.3e-13
5 PL gene expression Rinl 0.02 0.02 6.4e-03 -0 0 0 -0 6.2e-01 1.1e-01 2.1e-01 7.7e-01
6 Liver isoform ratio XM_006228656.4 0.08 0.06 3.9e-06 0.03 0.03 0.03 0.03 2.6e-04 2.7e-04 1.8e-04 1.5e-04
7 Liver alternative polyA NM_001106241.2 0.08 0.05 1.3e-06 0.04 0.02 0.04 0.04 1.6e-05 1.3e-03 5.0e-05 1.7e-05
8 Liver alternative polyA XM_006228656.4 0.09 0.06 8.2e-08 0.04 0.04 0.04 0.04 1.3e-05 3.9e-05 1.0e-05 8.9e-06
9 Liver isoform ratio XM_039104237.1 0.03 0.03 4.3e-03 0.01 0 0 0 5.5e-02 2.4e-01 2.6e-01 2.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.10.10.20.0-0.30.3-0.10.3-0.3-0.2-0.4-0.5
Area under the delay curve0.10.10.2-0.50.40.1-0.2-0.4-0.0-0.1-0.00.0
BMI with tail0.10.30.8-0.40.70.3-0.7-0.9-0.6-0.5-0.5-0.5
BMI without tail0.20.40.90.9-0.4-0.80.40.10.50.80.60.5
Body weight2.610.813.22.2-3.3-3.23.63.63.43.53.33.2
Weight adjusted by age0.10.10.2-0.20.40.2-0.4-0.5-0.4-0.4-0.3-0.3
Bone surface0.40.81.80.9-1.3-0.61.01.30.60.70.60.5
Bone volume0.50.81.70.9-1.3-0.70.91.30.60.70.60.5
Breakpoint value in progressive ratio session0.80.91.60.2-0.1-1.20.5-0.31.31.31.21.2
Number of licking bursts1.31.53.2-0.30.61.3-1.1-0.5-1.6-1.8-1.5-1.4
Context. condit. distance diff. score0.10.10.1-0.30.30.2-0.3-0.3-0.3-0.3-0.2-0.1
Locomotion velocity, session 12.93.13.6-1.81.91.6-1.9-1.9-1.7-1.8-1.7-1.6
Locomotion distance, session 10.70.91.10.8-0.9-0.81.01.01.01.01.01.0
Locomotion velocity, session 20.40.50.7-0.90.70.8-0.7-0.6-0.7-0.5-0.6-0.6
Locomotion distance, session 20.71.01.8-1.11.30.9-1.1-1.3-0.7-0.7-0.7-0.8
Locomotion velocity, session 30.20.20.90.2-0.60.30.31.0-0.4-0.5-0.4-0.3
Locomotion distance, session 36.77.38.22.4-2.9-2.72.82.82.62.72.72.7
Stereotopy head waving bouts, day 30.50.61.0-0.60.90.6-0.8-1.0-0.7-0.9-0.6-0.5
Stereotopy head waving duration, day 32.63.13.5-1.71.81.7-1.8-1.8-1.8-1.9-1.8-1.7
Locomotion velocity, session 70.10.10.50.1-0.40.10.30.70.00.20.00.0
Locomotion distance, session 70.20.30.70.6-0.8-0.40.60.80.30.40.30.3
Stereotopy head waving bouts, day 70.00.10.2-0.20.40.1-0.3-0.4-0.1-0.1-0.1-0.0
Stereotopy head waving duration, day 71.11.32.2-1.21.41.0-1.3-1.5-1.0-1.0-1.0-0.9
Locomotion velocity, session 82.53.03.9-1.71.51.9-1.7-1.3-1.9-2.0-1.9-1.8
Locomotion distance, session 80.50.81.6-1.01.20.6-1.0-1.3-0.7-0.7-0.6-0.5
Degree of sensitization distance3.53.54.0-1.61.81.9-1.9-1.7-2.0-2.0-2.0-2.0
Degree of sensitization stereotypy0.10.10.3-0.20.3-0.1-0.2-0.50.00.10.10.1
Conditioned locomotion1.01.22.21.3-1.4-0.91.21.50.80.70.80.8
Cocaine response after cond. corrected0.70.81.51.2-1.1-0.70.91.10.70.80.80.8
Cocaine response after cond. not corrected1.21.42.21.5-1.4-1.01.21.31.01.01.01.0
Cocaine response before conditioning1.72.02.91.5-1.4-1.71.31.01.51.31.51.5
Saline control response0.30.41.00.7-0.1-1.00.2-0.40.70.80.70.7
Bone: connectivity density0.40.61.1-0.50.51.0-0.7-0.4-1.0-0.8-1.0-1.0
Bone: cortical apparent density2.63.44.9-1.82.21.7-2.0-2.2-1.7-1.7-1.7-1.6
Bone: cortical area2.03.03.81.4-1.5-1.91.71.41.91.81.91.9
Bone: cortical porosity0.50.60.7-0.90.70.9-0.8-0.7-0.7-0.7-0.7-0.7
Bone: cortical porosity0.60.70.9-0.90.80.9-0.8-0.8-0.8-0.8-0.8-0.7
Bone: cortical thickness0.91.52.11.1-1.1-1.51.20.91.31.21.31.3
Bone: cortical thickness0.00.00.10.1-0.00.2-0.00.2-0.2-0.3-0.1-0.0
Bone: cortical tissue density3.03.95.4-1.92.31.8-2.1-2.3-1.8-1.8-1.8-1.8
Condit. Reinf. active minus inactive responses0.10.20.50.10.10.3-0.4-0.1-0.6-0.7-0.5-0.3
Condit. Reinf. active-inactive response ratio0.10.10.4-0.20.20.2-0.4-0.3-0.5-0.7-0.3-0.2
Condit. Reinf. active responses0.70.91.2-0.50.71.0-0.9-0.6-1.1-1.1-1.1-1.0
Condit. Reinf. inactive responses0.60.71.1-0.50.81.0-0.8-0.6-0.8-0.6-0.9-1.0
Incentive salience index mean0.10.10.40.4-0.50.00.20.6-0.1-0.2-0.00.0
Condit. Reinf. lever presses0.20.30.80.5-0.7-0.30.60.90.40.50.40.4
Condit. Reinf. active minus inactive responses4.25.26.62.2-2.1-2.62.21.82.42.32.42.5
Condit. Reinf. active-inactive response ratio2.62.74.01.4-1.2-2.01.50.91.81.71.92.0
Condit. Reinf. active responses4.76.68.22.5-2.5-2.92.52.12.62.62.72.7
Condit. Reinf. inactive responses1.21.51.81.1-1.2-1.31.21.01.31.31.31.2
Condit. Reinf. lever presses7.19.610.83.1-3.2-3.33.13.03.02.93.13.1
Condit. Reinf. lever reinforcers received6.08.49.82.8-2.9-3.12.92.62.92.83.03.0
Conditioned reinforcement - actives1.21.24.82.2-1.3-1.10.81.00.50.50.60.6
Conditioned reinforcement - inactives2.32.64.21.2-1.8-1.31.92.11.61.61.61.5
Conditioned locomotion0.60.71.60.60.20.5-0.8-0.4-1.2-1.3-1.0-0.8
Patch foraging indifference point 0 sec0.40.61.31.2-0.9-0.80.70.70.70.60.70.7
Patch foraging indifference point AUC1.31.54.9-2.21.60.9-1.0-1.4-0.6-0.6-0.7-0.8
Delay disc. indifference point, 0s delay0.20.20.4-0.10.1-0.60.1-0.40.60.60.60.6
Delay disc. indifference point, 16s delay1.01.11.31.1-1.1-1.11.01.01.00.91.01.0
Delay disc. indifference point, 2s delay0.10.10.3-0.60.40.3-0.3-0.4-0.2-0.3-0.2-0.1
Delay disc. indifference point, 24s delay1.00.91.70.2-0.9-0.51.21.31.01.11.00.9
Delay disc. indifference point, 4s delay0.00.00.00.1-0.0-0.20.1-0.00.20.20.20.2
Delay disc. indifference point, 8s delay1.71.72.7-1.61.61.2-1.4-1.6-1.0-1.1-1.1-1.0
Indifference point function ln k1.11.53.92.0-1.7-1.01.21.60.70.70.80.8
Indifference point function log k1.11.53.92.0-1.7-1.01.21.60.70.70.80.8
Patch foraging total patch changes 0 sec0.50.71.41.2-1.0-0.80.80.90.80.70.80.8
Patch foraging total patch changes 12 sec0.20.20.4-0.3-0.1-0.50.40.10.60.50.50.5
Patch foraging total patch changes 18 sec0.91.23.9-2.01.60.6-0.9-1.5-0.3-0.4-0.4-0.5
Patch foraging total patch changes 24 sec0.40.40.8-0.0-0.4-0.80.70.50.90.80.70.6
Patch foraging total patch changes 6 sec0.10.10.2-0.40.3-0.20.0-0.30.30.40.30.3
Patch foraging time to switch 0 sec1.42.23.5-1.91.61.4-1.4-1.4-1.4-1.3-1.4-1.4
Patch foraging water rate 0 sec0.20.30.70.1-0.20.8-0.20.4-0.7-0.6-0.7-0.8
Patch foraging water rate 12 sec1.21.84.00.8-1.6-0.71.62.01.21.21.21.2
Patch foraging water rate 18 sec0.40.50.80.5-0.10.8-0.40.2-0.9-0.9-0.9-0.8
Patch foraging water rate 24 sec0.91.22.11.4-1.4-0.71.11.50.80.80.91.0
Patch foraging water rate 6 sec0.40.61.80.9-1.1-0.30.81.30.40.40.30.3
Seeking ratio, delayed vs. immediate footshock0.91.11.50.8-0.8-1.11.10.81.11.21.11.1
Distance traveled before self-admin2.02.12.51.1-1.4-1.51.51.31.61.51.51.5
Distance traveled after self-admin5.15.66.12.3-2.4-2.52.42.22.52.42.42.4
Extensor digitorum longus weight0.20.71.1-0.50.60.8-0.9-0.7-1.0-1.0-1.0-0.9
Bone: elastic displacement0.00.00.1-0.40.10.3-0.2-0.1-0.2-0.2-0.2-0.2
Bone: elastic work2.53.23.81.5-2.0-1.71.91.91.71.71.81.8
Bone: endosteal estimation0.91.92.71.0-1.1-1.51.30.91.61.61.51.5
Bone: endosteal perimeter0.91.82.21.2-1.2-1.41.31.11.41.51.41.3
Epididymis fat weight0.00.00.1-0.20.30.3-0.2-0.3-0.2-0.1-0.2-0.2
Delta time in closed arm before/after self-admin0.90.91.71.3-1.2-0.71.01.30.60.80.60.5
Delta time in open arm before/after self-admin0.00.00.00.00.10.1-0.1-0.1-0.0-0.0-0.1-0.1
Diff in mean of infusions in LGA sessions0.10.20.4-0.70.6-0.1-0.2-0.60.30.10.20.3
Delay discount exponential model param0.00.00.20.5-0.3-0.10.10.2-0.00.0-0.0-0.0
Extinction: sum of active levers before priming0.70.71.40.6-0.3-1.10.60.01.11.21.00.9
Active lever presses in extinction session 60.10.10.30.1-0.0-0.40.30.00.50.60.40.3
Bone: final force1.62.73.21.3-1.6-1.71.71.51.71.61.71.8
Bone: final moment2.64.24.61.7-2.1-2.12.12.02.12.02.12.1
Food consumed during 24 hour testing period0.60.81.61.0-1.2-0.71.01.30.60.60.60.7
Glucose0.20.30.7-0.4-0.10.8-0.10.5-0.7-0.5-0.7-0.8
Heart weight0.71.11.30.9-1.1-1.01.11.11.11.01.00.9
Delay discount hyperbolic model param0.10.10.30.5-0.4-0.20.20.40.10.10.10.1
Intermittent access intake day 1-15 change0.80.71.40.1-0.5-0.70.90.61.11.21.11.0
Intermittent access intake escalation0.60.61.00.4-0.6-0.80.80.60.91.00.90.8
Intermittent access intake escalation 22.01.93.40.3-0.7-1.51.20.51.81.91.81.7
Intermitt. access day 1 inactive lever presses0.80.92.41.3-1.3-0.41.01.50.50.60.40.4
Intermitt. access day 15 inactive lever presses0.60.72.31.2-1.2-0.20.91.50.30.30.30.3
Intermitt. access escalation Index0.40.41.71.3-0.4-0.90.2-0.10.40.40.50.5
Intermittent access day 1 total infusions0.91.04.52.1-1.5-0.90.61.1-0.0-0.10.20.4
Intermittent access day 15 total infusions1.61.83.31.8-1.6-1.41.21.41.00.91.11.2
Intermittent access terminal intake (last 3 days)1.92.12.61.5-1.6-1.51.51.51.31.31.41.5
Intermittent access total infusions1.71.95.02.2-1.8-1.41.21.50.80.71.01.1
Intermittent access day 1 locomotion1.51.69.33.0-1.6-1.10.51.0-0.0-0.10.20.3
Intermittent access day 15 total locomotion0.20.21.21.1-0.7-0.20.20.5-0.2-0.2-0.1-0.0
Intermittent access total locomotion0.40.42.11.4-0.5-0.0-0.20.3-0.7-0.7-0.6-0.5
Intermittent access standard deviation3.43.65.30.8-1.4-2.01.81.32.32.32.32.3
Left kidney weight3.18.79.92.7-3.1-3.13.23.12.93.02.82.7
Right kidney weight3.810.712.52.5-3.2-3.43.53.33.53.43.33.3
Cocaine induced anxiety0.10.20.8-0.90.50.3-0.2-0.4-0.0-0.1-0.1-0.1
Post-drug Anxiety0.70.81.0-1.01.00.8-0.9-1.0-0.7-0.8-0.8-0.8
Baseline Anxiety0.10.10.90.9-0.2-0.1-0.2-0.1-0.3-0.3-0.2-0.2
Tail length4.513.816.92.9-3.6-3.44.03.74.04.13.93.7
Length with tail7.025.631.03.7-5.1-4.75.65.55.35.35.15.0
Length without tail3.57.710.31.9-3.0-2.63.13.22.82.62.72.8
Times rat made contact with spout0.50.61.1-1.01.10.7-0.8-1.1-0.5-0.5-0.6-0.6
Lifetime Intake0.91.04.22.1-1.4-1.00.61.00.20.20.40.6
Liver weight, left0.00.10.1-0.00.30.2-0.3-0.3-0.2-0.1-0.2-0.3
Liver weight, right0.00.10.20.1-0.30.10.30.50.10.10.20.2
Locomotor activity0.91.54.9-2.21.41.2-1.0-1.2-0.7-0.5-0.8-0.9
Locomotor testing distance1.22.03.7-1.91.61.4-1.4-1.5-1.1-1.0-1.2-1.3
Locomotor testing rearing2.64.18.6-2.92.61.6-2.0-2.6-1.2-1.1-1.4-1.6
Locomotion in novel chamber0.70.91.9-0.91.20.6-1.1-1.4-0.7-0.6-0.7-0.8
Locomotion in novel chamber post-restriction0.00.00.0-0.20.00.10.10.10.10.20.10.1
Fecal boli incidents, locomotor time 12.42.64.3-0.61.01.7-1.5-0.9-2.1-1.9-2.0-2.1
Change in fecal boli incidents, locomotor task0.30.30.70.00.4-0.6-0.2-0.90.50.40.50.5
Time >=10cm from walls, locomotor time 10.00.00.10.30.00.1-0.1-0.0-0.1-0.1-0.2-0.3
Bouts of movement, locomotor time 10.10.10.30.5-0.0-0.40.1-0.20.40.30.20.1
Total resting periods, locomotor time 10.10.10.40.6-0.1-0.40.1-0.10.20.30.1-0.0
Rest time, locomotor task time 10.10.10.30.5-0.30.0-0.10.2-0.3-0.2-0.3-0.3
Distance moved, locomotor task time 10.10.10.3-0.40.0-0.20.30.10.40.50.50.5
Vertical activity count, locomotor time 10.91.01.60.4-0.7-1.10.90.61.21.31.21.2
Time >=10cm from walls, locomotor time 20.00.00.1-0.10.20.0-0.0-0.20.20.10.10.0
Bouts of movement, locomotor time 20.30.30.70.6-0.00.5-0.30.1-0.6-0.8-0.8-0.8
Total resting periods, locomotor time 20.30.30.70.50.00.5-0.30.0-0.6-0.8-0.8-0.9
Rest time, locomotor task time 20.40.50.60.7-0.8-0.60.70.80.60.60.60.6
Distance moved, locomotor task time 20.20.20.7-0.70.70.2-0.5-0.8-0.2-0.2-0.2-0.2
Vertical activity count, locomotor time 20.10.10.3-0.40.4-0.2-0.1-0.60.30.40.20.1
Light reinforcement 10.40.83.2-1.80.90.9-0.6-0.6-0.5-0.5-0.6-0.7
Light reinforcement 25.57.310.4-1.72.12.9-2.7-2.0-3.2-3.1-3.1-3.0
Bone: marrow area0.91.92.81.0-1.1-1.51.30.91.61.71.61.5
Bone: maximum diameter1.62.93.51.7-1.9-1.81.81.81.61.71.61.6
Bone: maximum force2.64.55.71.9-1.9-2.42.11.72.22.12.32.3
Bone: maximum moment3.66.27.72.3-2.4-2.82.42.12.62.52.62.7
Mean time between licks in bursts0.20.30.60.7-0.6-0.50.50.60.50.30.50.5
Mean num. licks in bursts0.50.61.6-0.30.2-0.70.4-0.31.11.21.00.8
Cd content in liver0.91.02.6-1.21.40.7-1.1-1.6-0.7-0.7-0.6-0.6
Co content in liver1.41.62.4-0.70.91.1-1.4-1.1-1.5-1.5-1.4-1.4
Cu content in liver1.72.03.61.3-1.8-1.31.61.91.21.11.21.1
Fe content in liver0.30.40.7-0.50.40.8-0.4-0.1-0.7-0.6-0.7-0.7
K content in liver0.90.91.60.8-1.2-0.91.11.20.90.80.80.7
Mg content in liver0.30.30.90.4-0.8-0.30.61.00.30.20.20.2
Mn content in liver0.50.60.80.7-0.7-0.90.70.50.90.80.80.8
Na content in liver5.35.66.52.1-2.3-2.42.42.22.52.52.42.4
Rb content in liver0.00.00.1-0.3-0.10.10.10.20.0-0.0-0.0-0.0
Se content in liver3.23.95.7-2.42.12.0-2.0-1.9-1.9-1.8-1.9-1.9
Sr content in liver0.40.40.6-0.00.30.4-0.7-0.5-0.8-0.8-0.7-0.7
Zn content in liver0.20.20.4-0.20.00.4-0.30.1-0.6-0.6-0.6-0.6
Bone: minimum diameter4.48.211.12.1-2.2-3.32.61.63.33.33.33.3
Time in familiar zone, hab. session 10.20.20.40.1-0.3-0.50.30.10.50.70.50.5
Time in novel zone, hab. session 10.10.10.20.00.30.3-0.2-0.1-0.3-0.5-0.4-0.3
Total zone transitions, hab. session 10.30.40.7-0.10.1-0.80.3-0.40.80.80.80.8
Total locomotion distance, hab. session 11.72.53.90.9-0.7-1.91.30.42.02.02.02.0
Locomotion velocity, hab. session 10.60.91.60.4-0.2-1.20.70.01.21.21.21.3
Time in familiar zone, hab. session 20.30.30.50.3-0.5-0.50.60.60.60.60.70.7
Time in novel zone, hab. session 20.60.60.9-0.40.90.9-0.8-0.7-0.8-0.8-0.8-0.9
Total zone transitions, hab. session 20.00.00.2-0.00.40.3-0.2-0.2-0.1-0.2-0.00.0
Total locomotion distance, hab. session 20.30.40.80.6-0.2-0.60.50.20.70.60.80.9
Locomotion velocity, hab. session 20.20.30.70.6-0.2-0.60.50.20.70.60.70.9
Novel to familiar place preference ratio0.60.71.60.20.0-0.80.60.01.11.31.10.9
Novelty place preference0.60.61.50.2-0.1-0.70.70.21.11.21.00.9
Time in novel zone, NPP test0.30.30.90.00.1-0.50.4-0.00.81.00.80.6
Total zone transitions, NPP test0.20.20.3-0.50.50.6-0.5-0.4-0.5-0.4-0.4-0.4
Total locomotion distance, NPP test1.01.42.40.9-0.6-1.31.00.51.41.41.51.5
Locomotion velocity, NPP test1.42.03.11.1-0.9-1.51.30.71.61.71.71.8
Intraocular pressure0.10.10.4-0.6-0.20.3-0.10.2-0.3-0.2-0.3-0.4
Delta distance traveled before/after self-admin0.30.30.40.6-0.5-0.60.60.50.60.60.50.5
Delta ambulatory time before/after self-admin0.91.01.51.2-0.9-1.20.90.71.01.01.01.0
Parametrial fat weight0.30.71.2-0.40.50.9-0.7-0.4-1.0-1.0-1.0-1.1
Pavlov. Cond. lever latency0.20.20.4-0.20.60.5-0.5-0.5-0.5-0.5-0.5-0.5
Pavlov. Cond. magazine entry latency0.10.10.2-0.1-0.10.2-0.20.0-0.4-0.5-0.4-0.3
Pavlov. Cond. change in total contacts0.00.00.10.2-0.4-0.20.10.2-0.0-0.10.00.0
Pavlov. Cond. index score0.00.10.20.1-0.4-0.30.20.30.10.10.10.1
Pavlov. Cond. latency score0.10.10.30.2-0.5-0.40.30.40.20.30.30.3
Pavlov. Cond. lever contacts0.91.11.60.8-1.3-1.11.11.21.01.01.01.0
Pavlov. Cond. magazine entry number0.00.00.10.00.0-0.00.20.10.20.30.20.1
Pavlov. Cond. intertrial magazine entries0.20.20.5-0.40.60.3-0.5-0.7-0.3-0.4-0.3-0.4
Pavlov. Cond. lever-magazine prob. diff.0.20.20.50.4-0.7-0.50.40.60.30.30.40.4
Pavlov. Cond. response bias0.20.20.40.4-0.6-0.50.40.50.30.30.30.4
Pavlov. Cond. lever latency3.24.35.0-1.92.12.2-2.1-2.0-2.1-2.1-2.1-2.0
Pavlov. Cond. magazine entry latency2.42.74.71.8-2.0-1.51.82.21.31.31.31.3
Pavlov. Cond. change in total contacts5.67.89.22.5-2.7-3.02.82.42.92.82.92.9
Pavlov. Cond. index score3.13.94.92.0-2.2-2.02.12.21.91.81.81.8
Pavlov. Cond. latency score3.03.84.91.9-2.2-1.92.02.21.81.81.81.8
Pavlov. Cond. lever contacts3.04.14.71.9-2.1-2.22.01.92.02.02.02.0
Pavlov. Cond. magazine entry number1.31.62.7-1.31.61.1-1.4-1.6-1.0-1.0-1.0-1.0
Pavlov. Cond. intertrial magazine entries0.50.71.1-0.70.61.0-0.7-0.3-1.0-1.0-1.0-0.9
Pavlov. Cond. lever-magazine prob. diff.3.54.55.52.1-2.4-2.22.22.32.02.02.02.0
Pavlov. Cond. response bias3.54.85.42.1-2.3-2.32.22.22.12.12.12.1
Time in closed arm before self-admin0.10.10.2-0.30.20.0-0.2-0.3-0.2-0.4-0.10.2
Time in closed arm after self-admin0.70.72.31.5-1.2-0.70.71.00.20.10.40.6
Time in open arm before self-admin1.11.21.70.7-1.1-0.91.21.21.21.31.10.9
Time in open arm after self-admin0.70.81.90.3-0.4-0.80.90.51.31.41.00.7
Bone: periosteal estimation1.73.54.71.5-1.6-2.11.81.32.12.22.12.0
Bone: periosteal perimeter1.42.43.01.5-1.3-1.71.51.11.71.71.71.6
Bone: post-yield work0.50.71.21.1-0.5-1.00.70.40.90.80.91.0
Progressive ratio test 1 active lever presses4.34.512.53.5-2.6-2.21.82.11.31.31.51.6
Progressive ratio test 1 breakpoint4.34.510.13.2-2.6-2.22.02.21.61.51.71.7
Progressive ratio test 1 inactive lever presses1.41.66.52.5-1.6-1.11.01.40.50.60.50.5
Progressive ratio test 2 active lever presses1.92.16.62.6-1.9-1.31.21.60.80.70.80.8
Progressive ratio test 2 breakpoint2.12.37.32.7-2.0-1.41.31.80.80.80.80.9
Progressive ratio test 2 inactive lever presses3.84.48.02.8-2.5-2.02.12.41.71.71.81.8
Incentive Sensitization - Responses0.10.10.30.4-0.40.10.20.5-0.1-0.1-0.2-0.3
Incentive Sensitization - Breakpoint0.10.10.20.1-0.10.4-0.00.3-0.3-0.3-0.4-0.5
Sum of active levers in priming session hrs 5-60.80.82.5-1.41.40.1-0.7-1.60.20.10.10.1
Progressive ratio0.80.91.6-1.01.20.8-1.1-1.3-0.8-0.7-0.7-0.7
Food seeking constrained by brief footshock2.43.04.41.7-1.5-2.11.61.11.81.81.92.0
Seeking ratio, punishment vs. effort2.53.14.11.9-2.0-1.71.91.91.61.51.61.7
Retroperitoneal fat weight1.03.24.5-2.11.72.0-1.6-1.2-1.7-1.6-1.9-2.0
Reaction time number correct0.10.10.20.5-0.4-0.10.30.30.30.30.40.4
Reaction time mean minus median0.30.30.80.2-0.8-0.30.70.90.50.30.50.6
Reaction time mean minus median AUC0.50.71.70.7-1.1-0.61.01.30.60.40.60.6
Reaction time num false alarms0.70.91.30.20.70.3-1.2-1.1-1.1-1.1-1.1-1.2
Reaction time num false alarms AUC1.01.31.90.00.90.5-1.4-1.3-1.3-1.3-1.3-1.4
Reaction time trials correct on left0.10.10.20.5-0.4-0.10.30.30.30.30.40.4
Reaction time trials on left0.10.10.30.5-0.4-0.10.30.30.30.30.30.3
Reaction time mean0.10.10.20.1-0.40.00.10.4-0.3-0.4-0.2-0.1
Reaction time mean AUC0.10.20.40.3-0.50.20.00.5-0.5-0.6-0.4-0.3
Median of all reaction times0.10.10.40.1-0.20.1-0.20.1-0.6-0.6-0.5-0.4
Reaction time omissions0.10.10.30.4-0.00.1-0.3-0.2-0.5-0.4-0.3-0.2
Reaction time false alarm rate1.01.32.0-0.20.90.6-1.3-1.2-1.3-1.4-1.4-1.4
Reaction time premature initiation rate0.00.00.0-0.20.20.0-0.1-0.2-0.0-0.00.00.0
Reaction time premature initiations0.00.00.0-0.00.0-0.00.0-0.10.10.10.20.2
Std. dev. reaction times0.20.31.00.3-0.9-0.40.71.00.30.10.30.5
Reaction time trials completed0.10.10.30.5-0.4-0.10.30.30.30.30.30.3
Reaction time trials AUC0.00.10.20.5-0.3-0.10.20.20.20.20.20.3
Run reversals in cocaine runway, females0.30.30.40.3-0.40.5-0.00.6-0.6-0.6-0.6-0.6
Run reversals in cocaine runway, males0.80.81.3-1.20.90.9-0.9-0.8-0.7-0.8-0.8-0.8
Latency to leave start box in cocaine runway0.20.31.1-1.00.60.7-0.2-0.2-0.3-0.3-0.3-0.3
Latency to leave start box in cocaine runway, F0.80.92.0-1.41.21.1-0.8-0.9-0.7-0.8-0.7-0.7
Latency to leave start box in cocaine runway, M0.10.10.30.3-0.5-0.20.40.60.10.20.20.2
Std. dev. time between licks in bursts0.40.50.70.6-0.4-0.80.60.30.80.80.80.8
Total sessions with >9 infusions0.40.53.11.8-0.7-0.80.10.1-0.1-0.10.10.2
Short access day 1 total inactive lever presses0.70.71.51.2-1.1-0.70.91.10.60.60.60.6
Short access day 10 total inactive lever presses0.40.41.11.0-0.9-0.50.61.00.30.30.40.4
Short access day 1 total infusions0.91.02.61.6-1.2-1.00.91.00.70.70.70.7
Short access day 10 total infusions0.30.31.71.3-0.6-0.4-0.00.2-0.3-0.4-0.10.0
Short access total infusions0.40.53.01.7-0.7-0.50.00.3-0.2-0.3-0.2-0.1
Short access day 1 locomotion1.01.11.7-0.00.90.9-1.2-1.1-1.1-1.1-1.2-1.3
Short access day 10 total locomotion1.41.67.22.7-1.5-1.40.80.90.50.50.70.8
Short access total locomotion0.70.75.02.2-0.6-0.6-0.2-0.0-0.3-0.4-0.3-0.3
One hour access (0.3 mA shock)1.92.24.42.1-1.7-1.71.31.31.11.11.31.5
Compulsive drug intake0.20.20.30.00.0-0.50.2-0.30.50.60.60.6
One hour access (shock baseline)0.60.71.71.3-1.2-0.80.81.10.40.40.50.6
Social response proportion5.05.46.62.2-2.4-2.22.32.12.32.32.52.6
Social responses0.20.20.60.2-0.6-0.00.50.80.30.40.30.2
Social time0.20.30.6-0.60.0-0.20.40.10.70.80.60.5
Soleus weight1.33.85.7-2.32.31.7-2.1-2.4-1.7-1.7-1.6-1.6
Bone: stiffness1.21.92.81.2-1.1-1.71.30.81.51.41.61.7
Tibialis anterior weight0.00.20.7-0.40.6-0.0-0.4-0.80.00.0-0.0-0.0
Time to tail flick, vehicle, before self-admin0.40.41.31.1-0.8-0.50.60.90.40.40.40.5
Time to tail flick, vehicle, after self-admin0.50.51.11.0-1.0-0.60.71.00.30.40.50.5
Time to tail flick, test, before self-admin0.00.00.00.1-0.0-0.10.10.10.20.10.20.2
Time to tail flick, test, after self-admin0.10.10.70.8-0.5-0.40.20.30.0-0.00.10.2
Delta time to tail flick, vehicle, before/after SA0.10.10.20.3-0.4-0.40.30.40.20.30.30.2
Delta time to tail flick, test, before/after SA0.00.00.10.3-0.3-0.10.10.3-0.1-0.0-0.00.0
Tibia length2.36.67.82.4-2.8-2.62.72.72.52.52.42.4
Ambulatory time before self-admin1.01.01.40.6-0.9-1.01.00.91.21.11.11.1
Ambulatory time after self-admin5.15.66.42.0-2.3-2.42.52.22.52.42.52.5
Bone: tissue strength4.44.24.92.0-2.1-2.22.01.82.12.12.12.1
Total heroin consumption0.81.01.9-0.20.2-1.10.5-0.61.41.31.31.2
Bone: trabecular number0.10.20.50.5-0.7-0.40.40.60.30.40.30.2
Bone: trabecular spacing1.31.72.51.1-0.9-1.61.20.81.51.51.51.6
Bone: trabecular thickness0.10.10.30.2-0.40.40.00.5-0.4-0.3-0.4-0.5
Bone: trabecular tissue density2.73.84.5-2.12.12.0-2.0-1.9-1.9-1.8-1.9-2.0
Water consumed over 24 hours1.11.31.81.2-1.2-1.01.21.31.11.11.11.1
Number of responses in last shaping day2.42.43.10.9-1.5-1.41.71.61.71.81.71.7