Hub : Genes

Rhbdd3

rhomboid domain containing 3

chr14:84208155–84214334 (+)

Rhbdd3 RatGTEx page

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc intron excision ratio chr14_84209276_84209432 0.14 0.13 7.6e-03 0 0.01 0 0.01 6.0e-02 1.4e-02 1.6e-01 2.9e-02
2 BLA gene expression Rhbdd3 0.14 0.1 1.8e-03 0.04 0.03 0.06 0.03 4.3e-03 1.5e-02 6.7e-04 1.2e-02
3 PL gene expression Rhbdd3 0.09 0.06 1.6e-05 0.05 0.05 0.04 0.05 4.6e-06 4.5e-06 1.6e-05 3.6e-06
4 NAcc gene expression Rhbdd3 0.05 0.03 1.8e-07 0.04 0.04 0.03 0.04 5.1e-07 1.2e-06 9.2e-06 3.3e-06
5 NAcc mRNA stability Rhbdd3 0.04 0.03 2.1e-03 0.01 0.01 0.01 0.01 1.4e-02 1.9e-02 1.8e-02 6.0e-03
6 pVTA gene expression Rhbdd3 0.13 0.07 6.9e-09 0.11 0.11 0.12 0.11 1.8e-09 3.5e-09 9.4e-10 2.2e-09
7 Brain isoform ratio XM_039091738.2 0.08 0.06 4.7e-04 0.04 0.03 0.03 0.01 1.4e-04 9.3e-04 6.3e-04 8.9e-02
8 Brain gene expression Rhbdd3 0.06 0.05 2.6e-03 0.03 0.04 0.02 0 5.4e-04 1.2e-04 1.2e-02 1.2e-01
9 Liver gene expression Rhbdd3 0.07 0.05 8.2e-03 0.01 0.01 0.01 0.01 9.5e-03 7.1e-03 9.1e-03 8.3e-03
10 Liver intron excision ratio chr14_84208594_84208781 0.06 0.04 3.1e-03 0.02 0.02 0.02 0.01 4.5e-03 4.2e-03 3.2e-03 1.0e-02
11 Adipose gene expression Rhbdd3 0.19 0.09 1.3e-10 0.09 0.09 0.08 0.09 1.1e-09 4.5e-10 3.8e-09 6.4e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.10.10.20.40.3-0.2-0.1-0.2-0.20.2-0.4-0.30.4-0.4
Area under the delay curve2.22.54.1-2.0-2.0-1.9-1.5-1.5-1.71.5-1.4-1.21.1-1.1
BMI with tail0.00.10.3-0.2-0.30.20.30.30.2-0.30.30.4-0.50.4
BMI without tail0.61.83.4-1.8-0.9-1.4-1.3-1.3-1.41.3-1.3-1.41.2-1.3
Body weight1.14.87.5-2.7-2.5-2.5-2.2-2.2-2.32.1-2.0-1.91.7-1.7
Weight adjusted by age1.01.51.9-1.4-0.6-1.2-1.3-1.3-1.21.2-1.3-1.31.3-1.3
Bone surface0.20.30.60.2-0.7-0.8-0.5-0.6-0.60.5-0.7-0.30.5-0.4
Bone volume0.20.30.60.2-0.6-0.8-0.5-0.6-0.60.6-0.8-0.40.6-0.5
Breakpoint value in progressive ratio session0.40.40.9-0.9-0.7-0.9-0.6-0.7-0.80.6-0.6-0.50.5-0.4
Number of licking bursts1.82.94.0-1.7-2.0-2.0-1.7-1.8-1.81.8-1.7-1.51.4-1.4
Context. condit. distance diff. score2.63.25.02.12.22.11.81.81.9-1.81.61.4-1.31.3
Locomotion velocity, session 12.02.13.41.1-0.21.11.51.51.4-1.51.61.7-1.81.9
Locomotion distance, session 10.10.21.20.41.10.40.10.10.2-0.1-0.1-0.20.3-0.3
Locomotion velocity, session 21.82.13.41.6-0.21.01.51.51.3-1.51.51.8-1.81.8
Locomotion distance, session 22.43.35.32.31.61.91.81.81.8-1.81.71.8-1.61.7
Locomotion velocity, session 31.21.43.51.81.91.41.11.11.2-1.10.80.7-0.60.6
Locomotion distance, session 30.10.10.90.9-0.4-0.3-0.1-0.1-0.20.1-0.40.10.2-0.0
Stereotopy head waving bouts, day 30.30.41.30.91.20.80.60.60.7-0.60.40.3-0.20.2
Stereotopy head waving duration, day 31.61.93.51.01.91.71.41.41.5-1.41.41.0-1.11.0
Locomotion velocity, session 70.00.00.30.1-0.6-0.2-0.2-0.2-0.10.2-0.20.10.00.0
Locomotion distance, session 70.70.91.91.40.40.91.01.00.9-1.00.81.0-0.91.0
Stereotopy head waving bouts, day 70.00.00.1-0.40.20.0-0.1-0.10.00.1-0.1-0.20.1-0.2
Stereotopy head waving duration, day 70.20.20.4-0.40.1-0.3-0.4-0.4-0.30.4-0.5-0.60.6-0.6
Locomotion velocity, session 83.13.85.72.41.11.92.02.02.0-2.01.92.1-1.92.0
Locomotion distance, session 86.18.912.93.43.63.53.03.03.2-3.02.72.4-2.32.3
Degree of sensitization distance2.72.83.51.21.41.91.81.81.8-1.81.81.5-1.71.6
Degree of sensitization stereotypy0.20.20.8-0.9-0.3-0.4-0.5-0.5-0.40.5-0.4-0.50.4-0.5
Conditioned locomotion0.30.31.70.81.30.60.10.20.4-0.2-0.0-0.20.4-0.3
Cocaine response after cond. corrected1.62.03.0-1.7-1.5-1.6-1.4-1.4-1.51.4-1.2-1.21.1-1.1
Cocaine response after cond. not corrected3.03.55.1-2.3-1.5-2.0-1.9-1.9-2.01.9-1.7-1.81.7-1.7
Cocaine response before conditioning0.10.10.7-0.00.80.30.0-0.00.1-0.0-0.0-0.20.2-0.3
Saline control response1.11.42.91.70.71.21.11.21.3-1.21.01.2-1.11.1
Bone: connectivity density0.00.10.30.50.50.20.10.00.1-0.0-0.1-0.10.2-0.2
Bone: cortical apparent density0.50.71.1-0.9-1.0-1.0-0.8-0.9-1.00.9-0.8-0.80.7-0.7
Bone: cortical area2.43.75.1-1.9-2.0-2.3-2.0-2.0-2.02.0-1.9-1.71.7-1.6
Bone: cortical porosity0.20.20.2-0.4-0.2-0.4-0.4-0.4-0.40.4-0.4-0.50.5-0.5
Bone: cortical porosity0.00.00.2-0.10.40.1-0.0-0.00.00.0-0.0-0.20.2-0.2
Bone: cortical thickness2.84.65.3-1.8-1.6-2.3-2.3-2.3-2.22.3-2.3-2.12.2-2.1
Bone: cortical thickness0.30.31.20.11.10.1-0.3-0.3-0.10.3-0.5-0.70.8-0.8
Bone: cortical tissue density0.50.71.1-0.9-1.1-1.0-0.8-0.8-0.90.9-0.8-0.70.6-0.6
Condit. Reinf. active minus inactive responses0.60.61.40.7-1.20.10.60.60.4-0.60.61.1-1.01.1
Condit. Reinf. active-inactive response ratio3.73.96.31.5-0.21.42.02.01.8-2.12.22.4-2.52.5
Condit. Reinf. active responses0.30.30.80.8-0.9-0.00.40.40.2-0.40.30.8-0.70.7
Condit. Reinf. inactive responses0.91.11.8-0.1-0.5-1.0-1.1-1.1-1.01.1-1.3-1.01.2-1.2
Incentive salience index mean0.20.31.90.3-1.4-0.50.00.0-0.2-0.0-0.00.5-0.40.5
Condit. Reinf. lever presses0.20.30.50.0-0.6-0.7-0.5-0.5-0.60.6-0.7-0.30.5-0.4
Condit. Reinf. active minus inactive responses0.50.71.41.20.70.80.90.80.8-0.90.70.7-0.70.7
Condit. Reinf. active-inactive response ratio0.20.20.30.60.10.30.50.40.4-0.50.40.5-0.50.5
Condit. Reinf. active responses0.81.21.91.40.91.11.21.21.1-1.21.01.0-0.91.0
Condit. Reinf. inactive responses1.01.41.71.21.01.31.21.31.2-1.31.21.1-1.01.1
Condit. Reinf. lever presses0.30.41.31.10.80.70.60.60.6-0.60.40.5-0.30.4
Condit. Reinf. lever reinforcers received0.70.91.81.30.70.91.11.00.9-1.00.90.9-0.80.9
Conditioned reinforcement - actives0.20.41.2-1.1-0.4-0.7-0.6-0.6-0.70.7-0.4-0.50.4-0.4
Conditioned reinforcement - inactives0.30.51.1-0.9-1.0-0.8-0.7-0.7-0.70.7-0.5-0.40.3-0.3
Conditioned locomotion1.21.62.3-1.5-1.0-1.3-1.4-1.4-1.31.3-1.2-1.11.1-1.1
Patch foraging indifference point 0 sec1.52.83.9-2.0-1.8-1.9-1.7-1.7-1.71.8-1.5-1.41.3-1.3
Patch foraging indifference point AUC0.00.00.20.1-0.40.00.10.10.1-0.10.10.2-0.20.2
Delay disc. indifference point, 0s delay1.61.82.8-1.7-1.1-1.5-1.3-1.3-1.51.3-1.3-1.31.2-1.2
Delay disc. indifference point, 16s delay0.60.72.5-1.4-1.6-1.0-0.6-0.6-0.80.6-0.3-0.20.1-0.0
Delay disc. indifference point, 2s delay3.43.84.2-2.0-1.2-2.0-2.0-2.0-2.02.0-2.0-2.12.0-2.0
Delay disc. indifference point, 24s delay0.30.31.7-0.5-1.3-0.8-0.4-0.4-0.60.4-0.3-0.10.1-0.0
Delay disc. indifference point, 4s delay3.73.95.2-2.3-1.8-2.2-2.0-2.0-2.12.0-1.9-1.91.8-1.8
Delay disc. indifference point, 8s delay0.40.51.5-0.9-1.2-0.9-0.7-0.7-0.70.7-0.6-0.40.4-0.4
Indifference point function ln k0.10.20.40.20.1-0.4-0.4-0.4-0.40.5-0.6-0.50.6-0.6
Indifference point function log k0.10.20.40.20.1-0.4-0.4-0.4-0.40.5-0.6-0.50.6-0.6
Patch foraging total patch changes 0 sec1.32.43.3-1.8-1.8-1.8-1.6-1.6-1.61.6-1.4-1.31.1-1.1
Patch foraging total patch changes 12 sec1.11.42.6-1.6-1.2-1.2-1.3-1.3-1.11.2-1.0-1.10.9-1.0
Patch foraging total patch changes 18 sec0.30.43.0-0.9-1.7-0.6-0.2-0.2-0.40.30.00.2-0.40.4
Patch foraging total patch changes 24 sec1.11.92.50.91.31.61.51.41.5-1.41.61.3-1.31.3
Patch foraging total patch changes 6 sec0.91.43.5-1.1-1.9-1.5-1.2-1.2-1.21.2-1.2-0.90.9-0.8
Patch foraging time to switch 0 sec0.10.21.1-0.11.00.60.30.30.4-0.30.40.1-0.10.1
Patch foraging water rate 0 sec0.40.83.8-0.6-1.9-1.2-0.8-0.7-0.90.8-0.7-0.30.1-0.2
Patch foraging water rate 12 sec0.00.00.20.4-0.3-0.1-0.00.00.00.0-0.10.2-0.10.1
Patch foraging water rate 18 sec0.91.42.4-1.30.6-0.6-1.2-1.2-0.91.1-1.1-1.61.4-1.6
Patch foraging water rate 24 sec0.20.30.70.3-0.20.40.50.60.5-0.50.70.7-0.80.8
Patch foraging water rate 6 sec0.40.60.8-0.7-0.7-0.9-0.9-0.8-0.80.8-0.9-0.80.8-0.8
Seeking ratio, delayed vs. immediate footshock0.10.10.5-0.70.40.20.20.10.1-0.20.40.0-0.20.1
Distance traveled before self-admin1.41.92.5-1.4-0.4-1.5-1.4-1.3-1.21.4-1.5-1.51.6-1.6
Distance traveled after self-admin1.41.82.9-1.20.0-1.0-1.3-1.3-1.21.3-1.5-1.71.6-1.7
Extensor digitorum longus weight3.011.715.7-3.2-4.0-4.0-3.6-3.6-3.63.5-3.4-2.92.9-2.8
Bone: elastic displacement0.20.20.6-0.30.80.2-0.2-0.2-0.10.3-0.2-0.60.5-0.6
Bone: elastic work1.41.82.8-1.60.0-1.0-1.3-1.3-1.21.4-1.3-1.71.5-1.6
Bone: endosteal estimation0.10.20.7-0.8-0.1-0.4-0.3-0.4-0.40.4-0.2-0.40.3-0.3
Bone: endosteal perimeter0.30.61.4-1.2-1.1-0.9-0.8-0.8-0.80.7-0.6-0.60.5-0.5
Epididymis fat weight0.51.62.2-0.6-1.4-1.4-1.3-1.3-1.31.3-1.5-1.11.2-1.2
Delta time in closed arm before/after self-admin5.14.810.51.83.22.72.32.22.4-2.32.01.5-1.51.4
Delta time in open arm before/after self-admin4.34.28.4-2.5-2.9-2.6-2.0-2.0-2.22.0-1.6-1.31.3-1.2
Diff in mean of infusions in LGA sessions0.00.00.2-0.20.50.10.10.00.1-0.10.1-0.10.0-0.1
Delay discount exponential model param2.22.44.01.92.01.81.51.51.7-1.51.41.2-1.11.1
Extinction: sum of active levers before priming0.20.20.40.5-0.50.00.30.20.3-0.30.40.7-0.50.6
Active lever presses in extinction session 60.20.20.5-0.70.3-0.3-0.4-0.4-0.30.4-0.4-0.60.6-0.6
Bone: final force0.20.40.6-0.6-0.6-0.7-0.6-0.6-0.60.6-0.6-0.50.6-0.5
Bone: final moment0.40.71.0-0.8-0.7-1.0-0.9-0.9-0.90.8-0.8-0.80.8-0.8
Food consumed during 24 hour testing period0.30.53.5-0.0-1.9-0.8-0.1-0.1-0.50.1-0.10.4-0.40.5
Glucose3.35.337.9-1.0-6.2-1.80.10.1-0.7-0.10.72.0-2.32.4
Heart weight0.71.12.01.3-0.70.51.01.00.7-1.01.01.4-1.31.4
Delay discount hyperbolic model param2.52.84.22.02.01.91.71.71.8-1.71.51.4-1.31.3
Intermittent access intake day 1-15 change0.10.31.80.1-1.3-0.6-0.2-0.2-0.40.1-0.00.4-0.20.4
Intermittent access intake escalation0.10.21.50.3-1.2-0.5-0.1-0.1-0.30.1-0.00.4-0.20.4
Intermittent access intake escalation 20.10.10.40.4-0.7-0.3-0.1-0.1-0.1-0.0-0.00.2-0.00.2
Intermitt. access day 1 inactive lever presses0.10.40.60.40.50.60.70.80.7-0.70.70.6-0.70.6
Intermitt. access day 15 inactive lever presses0.20.53.40.2-1.9-0.6-0.2-0.1-0.20.10.20.7-0.50.7
Intermitt. access escalation Index0.91.32.11.4-0.40.81.01.00.9-1.01.11.4-1.31.5
Intermittent access day 1 total infusions1.01.53.8-1.9-0.2-1.1-1.3-1.3-1.11.2-1.1-1.41.3-1.3
Intermittent access day 15 total infusions1.32.03.0-1.6-1.7-1.7-1.5-1.5-1.51.4-1.2-1.01.1-0.9
Intermittent access terminal intake (last 3 days)1.21.63.6-1.9-1.0-1.4-1.4-1.2-1.31.1-1.0-1.01.1-1.0
Intermittent access total infusions1.72.04.2-2.0-1.1-1.5-1.5-1.5-1.51.4-1.2-1.21.3-1.2
Intermittent access day 1 locomotion0.40.51.0-1.00.4-0.4-0.7-0.7-0.50.5-0.6-0.90.8-0.9
Intermittent access day 15 total locomotion0.61.22.5-1.6-1.1-1.3-1.1-1.1-1.21.1-0.9-0.80.8-0.7
Intermittent access total locomotion1.11.42.5-1.6-1.1-1.3-1.3-1.3-1.21.2-1.0-0.91.0-0.9
Intermittent access standard deviation0.00.10.60.30.80.30.10.00.2-0.1-0.0-0.20.2-0.2
Left kidney weight0.41.73.3-1.8-0.2-0.9-1.3-1.3-1.01.2-1.1-1.71.5-1.6
Right kidney weight0.73.35.9-1.70.3-1.2-1.8-1.8-1.51.7-1.8-2.42.3-2.4
Cocaine induced anxiety1.21.85.0-0.8-2.2-1.7-1.3-1.3-1.61.3-1.2-0.70.9-0.7
Post-drug Anxiety0.90.94.30.0-2.1-1.3-0.9-0.9-1.10.9-0.8-0.20.5-0.2
Baseline Anxiety0.40.50.80.90.30.60.70.60.7-0.60.70.8-0.60.8
Tail length3.212.415.1-3.4-3.2-3.9-3.7-3.6-3.73.6-3.6-3.43.3-3.3
Length with tail2.711.913.9-3.4-3.3-3.7-3.6-3.6-3.63.5-3.5-3.33.2-3.1
Length without tail0.20.61.0-0.6-1.0-0.8-0.9-0.8-0.80.8-0.9-0.60.7-0.6
LgA early post infusion interval1.52.04.4-2.1-1.0-1.4-1.4-1.4-1.41.4-1.2-1.41.3-1.3
LgA late post infusion interval0.50.61.2-0.50.10.60.60.70.7-0.71.11.0-1.11.1
LgA early loading2.03.75.82.12.42.12.02.01.9-2.01.71.5-1.61.4
LgA late loading0.10.20.90.80.90.20.10.00.0-0.1-0.3-0.40.5-0.5
LgA early average infusions3.24.04.82.01.92.22.12.12.0-2.02.01.9-1.91.8
LgA late average infusions0.30.40.70.90.80.60.70.60.5-0.70.60.6-0.50.5
LgA early timeout3.13.35.22.30.71.71.91.91.7-1.81.72.0-1.91.9
LgA late timeout0.10.21.81.3-0.1-0.00.20.20.1-0.3-0.10.10.00.1
LgA early titration1.72.43.71.91.01.61.61.51.5-1.51.51.6-1.51.6
LgA late titration0.10.20.30.5-0.20.10.40.40.2-0.40.40.6-0.50.6
LgA total infusion1.92.63.11.61.51.71.81.71.6-1.61.71.6-1.51.5
Times rat made contact with spout1.82.13.51.5-0.50.91.51.41.2-1.41.41.9-1.81.9
Lifetime Intake2.02.45.0-2.2-1.0-1.6-1.6-1.6-1.61.5-1.4-1.51.5-1.4
Liver weight, left0.30.41.0-0.40.8-0.1-0.5-0.5-0.30.5-0.6-1.00.9-1.0
Liver weight, right0.20.32.60.11.60.60.20.20.3-0.20.1-0.30.3-0.4
Locomotor activity0.20.21.1-1.1-1.0-0.4-0.2-0.2-0.30.10.10.1-0.40.3
Locomotor testing distance1.01.82.9-1.7-0.6-1.2-1.4-1.4-1.31.4-1.3-1.61.3-1.5
Locomotor testing rearing1.02.03.4-1.6-1.8-1.6-1.4-1.4-1.51.4-1.3-1.11.0-1.0
Locomotion in novel chamber0.81.04.60.92.21.50.70.71.2-0.80.60.2-0.20.1
Locomotion in novel chamber post-restriction3.65.86.72.32.02.52.52.62.5-2.52.52.4-2.22.4
Fecal boli incidents, locomotor time 10.20.30.30.60.40.50.60.60.4-0.50.50.6-0.60.6
Change in fecal boli incidents, locomotor task0.60.61.10.8-0.60.20.60.60.5-0.70.81.0-1.01.0
Time >=10cm from walls, locomotor time 10.10.10.10.2-0.00.30.20.20.3-0.30.30.3-0.40.3
Bouts of movement, locomotor time 10.30.30.80.2-0.90.10.40.40.2-0.40.50.8-0.70.8
Total resting periods, locomotor time 10.80.91.70.7-0.40.61.01.00.7-0.91.01.3-1.21.3
Rest time, locomotor task time 10.30.40.80.9-0.30.20.60.60.3-0.60.50.8-0.70.8
Distance moved, locomotor task time 10.81.32.2-1.5-0.4-0.8-1.2-1.2-0.91.2-1.1-1.31.1-1.3
Vertical activity count, locomotor time 10.30.72.0-1.4-0.1-0.5-0.8-0.8-0.60.8-0.6-0.90.7-0.9
Time >=10cm from walls, locomotor time 20.10.20.4-0.70.60.50.30.30.4-0.30.60.3-0.50.4
Bouts of movement, locomotor time 20.00.00.00.00.0-0.2-0.0-0.0-0.10.00.00.10.10.0
Total resting periods, locomotor time 20.00.00.10.3-0.2-0.10.10.1-0.0-0.10.10.3-0.10.2
Rest time, locomotor task time 20.30.41.41.20.20.50.70.70.5-0.70.50.7-0.60.7
Distance moved, locomotor task time 20.00.00.2-0.40.30.3-0.0-0.00.10.00.1-0.1-0.1-0.1
Vertical activity count, locomotor time 20.10.20.8-0.90.2-0.1-0.3-0.3-0.30.3-0.2-0.40.2-0.4
Light reinforcement 10.51.31.9-0.9-0.4-1.0-1.2-1.2-1.11.2-1.2-1.21.4-1.3
Light reinforcement 21.11.73.3-1.8-0.1-1.0-1.4-1.4-1.11.3-1.1-1.51.5-1.5
Bone: marrow area0.00.10.6-0.7-0.0-0.3-0.2-0.3-0.30.2-0.1-0.30.2-0.2
Bone: maximum diameter1.52.810.3-1.6-3.2-2.2-1.4-1.5-1.81.5-1.3-0.70.7-0.6
Bone: maximum force0.40.80.9-0.8-0.5-1.0-0.9-0.9-0.90.9-0.9-0.91.0-0.9
Bone: maximum moment0.81.31.5-1.0-0.6-1.2-1.2-1.2-1.21.2-1.2-1.21.2-1.2
Mean time between licks in bursts0.30.71.40.4-1.00.10.70.70.4-0.70.81.1-1.11.2
Mean num. licks in bursts3.65.66.42.41.42.32.52.52.4-2.52.42.5-2.42.5
Cd content in liver0.10.10.8-0.0-0.9-0.4-0.0-0.0-0.2-0.00.00.3-0.30.3
Co content in liver0.60.70.9-0.6-0.5-0.8-0.9-0.9-0.90.9-0.9-0.90.9-0.9
Cu content in liver0.00.10.40.1-0.6-0.10.00.00.0-0.00.10.2-0.20.2
Fe content in liver2.93.54.41.91.62.12.02.02.0-2.01.91.7-1.71.7
K content in liver5.35.16.2-2.0-1.1-2.3-2.5-2.5-2.32.5-2.3-2.32.4-2.3
Mg content in liver0.90.91.2-0.6-0.5-1.0-1.1-1.1-0.91.1-1.0-0.91.0-0.9
Mn content in liver1.31.42.0-0.6-0.3-1.0-1.4-1.4-1.11.4-1.3-1.21.4-1.3
Na content in liver1.01.13.3-1.0-1.8-1.5-1.0-1.0-1.21.0-0.8-0.40.5-0.4
Rb content in liver2.63.03.5-1.8-1.5-1.8-1.8-1.8-1.81.9-1.7-1.61.7-1.6
Se content in liver2.73.24.2-1.2-0.9-1.9-2.0-2.0-1.92.0-2.0-1.71.9-1.8
Sr content in liver1.31.24.5-1.2-2.1-1.4-0.9-0.9-1.10.9-0.7-0.40.4-0.3
Zn content in liver0.80.91.2-0.7-0.6-1.0-1.1-1.1-0.91.1-1.0-1.01.0-1.0
Bone: minimum diameter0.10.10.2-0.40.3-0.2-0.3-0.3-0.30.3-0.3-0.40.4-0.4
Time in familiar zone, hab. session 10.10.10.20.50.40.30.10.10.2-0.10.10.1-0.00.1
Time in novel zone, hab. session 10.90.91.3-1.1-0.6-1.0-0.9-0.9-1.00.9-0.9-1.00.9-0.9
Total zone transitions, hab. session 10.10.10.40.6-0.4-0.00.20.20.1-0.20.10.3-0.20.3
Total locomotion distance, hab. session 10.20.30.5-0.1-0.5-0.6-0.6-0.6-0.60.6-0.7-0.50.6-0.5
Locomotion velocity, hab. session 10.00.00.10.3-0.2-0.00.10.10.0-0.10.00.2-0.10.2
Time in familiar zone, hab. session 21.51.62.90.61.71.61.31.31.4-1.31.40.9-1.00.9
Time in novel zone, hab. session 22.22.23.9-0.7-2.0-1.9-1.5-1.5-1.71.5-1.7-1.11.2-1.1
Total zone transitions, hab. session 20.30.41.3-0.2-1.1-0.8-0.6-0.6-0.70.6-0.6-0.30.4-0.3
Total locomotion distance, hab. session 20.20.31.70.2-1.3-0.7-0.4-0.4-0.50.4-0.40.10.10.0
Locomotion velocity, hab. session 20.40.52.0-0.2-1.4-0.9-0.6-0.6-0.80.6-0.6-0.20.4-0.2
Novel to familiar place preference ratio0.20.21.4-0.5-1.2-0.4-0.0-0.0-0.20.00.10.3-0.40.4
Novelty place preference0.20.21.6-0.5-1.2-0.5-0.0-0.0-0.20.00.10.3-0.40.4
Time in novel zone, NPP test0.20.21.5-0.4-1.2-0.5-0.1-0.1-0.20.10.00.3-0.40.4
Total zone transitions, NPP test0.10.10.80.60.90.3-0.0-0.00.10.0-0.2-0.20.4-0.3
Total locomotion distance, NPP test0.00.10.30.60.30.1-0.0-0.0-0.00.0-0.2-0.10.3-0.2
Locomotion velocity, NPP test0.00.00.10.30.1-0.1-0.2-0.2-0.20.2-0.3-0.20.3-0.2
Intraocular pressure0.20.40.70.3-0.90.10.50.50.3-0.40.60.8-0.80.9
Delta distance traveled before/after self-admin0.50.51.00.60.91.00.70.70.7-0.70.60.4-0.60.4
Delta ambulatory time before/after self-admin0.50.61.31.00.91.10.80.80.9-0.80.60.5-0.60.5
Parametrial fat weight0.81.86.4-0.1-2.5-0.20.70.70.2-0.71.21.8-1.92.0
Pavlov. Cond. lever latency0.10.10.7-0.9-0.6-0.3-0.2-0.2-0.20.10.0-0.1-0.10.1
Pavlov. Cond. magazine entry latency1.62.13.71.91.91.61.41.41.4-1.31.21.2-1.01.0
Pavlov. Cond. change in total contacts0.40.41.50.1-1.2-0.9-0.5-0.5-0.70.6-0.7-0.10.3-0.2
Pavlov. Cond. index score1.11.43.61.91.81.31.11.11.1-1.00.80.9-0.60.6
Pavlov. Cond. latency score0.81.02.61.61.61.20.90.91.0-0.80.60.7-0.50.5
Pavlov. Cond. lever contacts0.30.41.71.31.00.60.50.50.5-0.40.20.3-0.10.1
Pavlov. Cond. magazine entry number2.12.76.3-2.5-1.8-1.7-1.6-1.6-1.61.5-1.2-1.51.1-1.2
Pavlov. Cond. intertrial magazine entries1.82.13.6-1.9-0.5-1.2-1.6-1.6-1.31.5-1.3-1.61.5-1.6
Pavlov. Cond. lever-magazine prob. diff.1.21.54.02.02.01.41.11.11.2-1.10.80.8-0.50.6
Pavlov. Cond. response bias0.60.73.21.81.20.80.70.70.7-0.60.30.6-0.20.3
Pavlov. Cond. lever latency5.87.99.2-3.0-2.1-2.9-3.0-3.0-2.92.9-2.8-2.82.7-2.7
Pavlov. Cond. magazine entry latency0.10.11.01.00.10.20.30.30.2-0.20.10.3-0.20.2
Pavlov. Cond. change in total contacts0.40.70.80.80.40.80.90.90.8-0.90.90.9-0.80.9
Pavlov. Cond. index score1.72.33.51.91.11.61.61.61.5-1.61.41.5-1.41.4
Pavlov. Cond. latency score1.72.33.82.01.31.61.61.61.5-1.51.41.4-1.31.3
Pavlov. Cond. lever contacts5.47.48.82.92.32.92.93.02.8-2.82.72.6-2.62.5
Pavlov. Cond. magazine entry number0.40.51.2-1.1-0.0-0.6-0.7-0.7-0.60.7-0.6-0.80.7-0.7
Pavlov. Cond. intertrial magazine entries0.00.00.00.1-0.10.1-0.00.00.1-0.10.10.1-0.00.1
Pavlov. Cond. lever-magazine prob. diff.1.62.23.51.91.21.51.61.61.5-1.51.41.4-1.31.3
Pavlov. Cond. response bias3.14.25.12.21.42.12.22.32.1-2.12.12.1-2.02.0
LgA PC1 addiction-like behavior0.71.43.01.71.11.21.31.21.1-1.21.01.1-1.01.0
Time in closed arm before self-admin1.01.31.8-1.3-0.3-1.0-1.1-1.1-1.11.1-1.1-1.31.2-1.3
Time in closed arm after self-admin0.91.04.00.82.01.31.00.91.1-1.00.70.2-0.40.2
Time in open arm before self-admin0.40.51.01.00.90.80.70.70.7-0.70.60.6-0.50.5
Time in open arm after self-admin0.20.20.9-0.7-0.9-0.6-0.1-0.0-0.30.10.30.4-0.30.5
Bone: periosteal estimation0.81.82.9-1.7-1.2-1.5-1.3-1.4-1.41.4-1.2-1.21.1-1.1
Bone: periosteal perimeter1.11.93.2-1.8-1.6-1.6-1.4-1.4-1.41.3-1.2-1.21.1-1.0
Bone: post-yield work0.10.10.20.1-0.4-0.5-0.3-0.3-0.40.2-0.3-0.10.2-0.2
Progressive ratio test 1 active lever presses0.91.12.3-1.5-0.7-1.1-1.1-1.0-1.10.9-0.9-1.01.0-0.9
Progressive ratio test 1 breakpoint0.70.91.8-1.3-0.7-1.0-1.0-0.9-1.00.9-0.8-0.80.9-0.8
Progressive ratio test 1 inactive lever presses2.53.66.9-2.1-2.6-2.3-2.0-1.9-2.01.9-1.6-1.31.3-1.2
Progressive ratio test 2 active lever presses0.81.02.0-1.4-1.0-1.2-1.0-1.0-1.11.0-0.8-0.70.7-0.7
Progressive ratio test 2 breakpoint0.60.61.3-1.2-0.9-1.0-0.8-0.8-0.90.8-0.6-0.50.5-0.5
Progressive ratio test 2 inactive lever presses0.40.61.7-1.2-1.3-1.0-0.7-0.7-0.90.8-0.4-0.20.2-0.1
ShA PR total presses2.52.95.81.62.42.11.71.71.9-1.61.61.3-1.31.2
Incentive Sensitization - Responses0.10.10.3-0.4-0.6-0.4-0.1-0.1-0.30.2-0.00.1-0.10.1
Incentive Sensitization - Breakpoint0.00.00.2-0.3-0.4-0.3-0.0-0.0-0.20.10.00.1-0.20.2
LgA PR total presses2.72.83.31.31.71.81.81.81.7-1.71.81.5-1.61.6
Sum of active levers in priming session hrs 5-60.20.20.50.2-0.7-0.7-0.3-0.4-0.50.3-0.6-0.40.5-0.4
Progressive ratio0.10.21.0-1.00.6-0.1-0.3-0.3-0.20.1-0.1-0.50.4-0.5
Food seeking constrained by brief footshock5.56.77.3-2.6-2.0-2.6-2.7-2.7-2.62.7-2.7-2.72.7-2.6
Seeking ratio, punishment vs. effort0.71.01.7-0.2-1.3-1.1-1.0-0.9-1.01.1-1.2-0.91.0-0.9
Retroperitoneal fat weight0.21.02.40.1-1.60.10.70.70.5-0.70.91.3-1.41.4
Reaction time number correct0.10.30.70.8-0.40.20.50.50.3-0.50.30.7-0.50.6
Reaction time mean minus median1.64.04.82.01.22.02.02.02.0-2.12.12.1-2.22.1
Reaction time mean minus median AUC0.71.72.21.51.11.51.31.31.4-1.31.31.2-1.41.2
Reaction time num false alarms0.71.11.7-0.1-0.4-1.0-1.1-1.1-1.01.1-1.3-1.01.1-1.2
Reaction time num false alarms AUC1.01.52.3-0.3-0.2-1.1-1.3-1.3-1.21.3-1.5-1.31.4-1.5
Reaction time trials correct on left0.10.30.70.8-0.40.20.50.50.3-0.50.30.7-0.50.6
Reaction time trials on left0.20.30.70.9-0.30.20.50.50.4-0.60.40.7-0.50.6
Reaction time mean0.91.51.90.91.11.41.31.21.3-1.31.31.1-1.31.1
Reaction time mean AUC1.01.52.21.01.41.51.31.21.3-1.31.31.0-1.21.0
Median of all reaction times0.50.71.00.40.91.00.90.80.9-0.91.00.6-0.80.7
Reaction time omissions1.01.52.71.31.61.51.31.21.3-1.21.20.9-0.90.8
Reaction time false alarm rate1.41.93.0-0.6-0.1-1.2-1.5-1.5-1.31.5-1.6-1.61.6-1.7
Reaction time premature initiation rate0.71.04.11.42.01.30.70.81.0-0.80.50.2-0.20.0
Reaction time premature initiations0.50.82.41.61.41.00.80.80.9-0.80.50.5-0.30.3
Std. dev. reaction times1.93.54.31.71.32.01.91.91.9-2.02.01.9-2.11.9
Reaction time trials completed0.20.30.70.9-0.30.20.50.50.4-0.60.40.7-0.50.6
Reaction time trials AUC0.10.10.40.6-0.40.00.30.30.2-0.40.20.5-0.30.5
Run reversals in cocaine runway, females1.21.21.91.41.01.01.21.21.1-1.21.01.0-1.01.0
Run reversals in cocaine runway, males0.60.60.7-0.8-0.8-0.8-0.7-0.8-0.80.9-0.8-0.80.6-0.7
Latency to leave start box in cocaine runway0.50.60.9-0.9-0.1-0.6-0.8-0.8-0.60.8-0.8-1.00.9-0.9
Latency to leave start box in cocaine runway, F2.12.42.9-1.5-0.9-1.6-1.6-1.5-1.41.6-1.6-1.71.7-1.7
Latency to leave start box in cocaine runway, M0.50.50.90.01.00.90.60.60.8-0.80.80.5-0.70.5
Std. dev. time between licks in bursts0.20.30.40.6-0.00.40.50.50.4-0.50.50.6-0.60.6
Total sessions with >9 infusions0.40.51.1-0.81.0-0.1-0.6-0.5-0.30.5-0.6-1.01.0-1.1
Short access day 1 total inactive lever presses4.45.88.6-2.9-2.3-2.6-2.4-2.5-2.52.5-2.3-2.22.1-2.1
Short access day 10 total inactive lever presses0.00.10.2-0.1-0.4-0.3-0.2-0.2-0.20.2-0.3-0.20.2-0.2
Short access day 1 total infusions0.40.51.2-0.70.7-0.2-0.6-0.6-0.40.6-0.7-1.01.0-1.1
Short access day 10 total infusions0.50.61.9-1.40.7-0.3-0.7-0.6-0.50.5-0.6-1.00.9-1.0
Short access total infusions1.52.03.9-2.0-0.0-1.1-1.4-1.4-1.31.3-1.3-1.61.6-1.6
ShA early post infusion interval2.12.03.4-1.8-1.3-1.6-1.5-1.5-1.51.4-1.2-1.21.2-1.1
ShA late post infusion interval0.40.42.1-1.5-0.3-0.5-0.6-0.6-0.50.7-0.4-0.60.4-0.5
ShA early loading0.70.71.00.70.81.00.80.81.0-0.80.90.8-0.80.8
ShA late loading4.96.79.13.02.52.92.72.72.7-2.62.52.4-2.32.2
Short access day 1 locomotion0.70.92.2-0.41.0-0.2-0.8-0.8-0.50.7-1.1-1.31.4-1.5
Short access day 10 total locomotion0.30.51.4-0.71.20.2-0.4-0.4-0.00.3-0.5-1.01.0-1.0
Short access total locomotion0.50.61.7-0.61.30.2-0.5-0.4-0.10.3-0.6-1.01.0-1.1
ShA early average infusions2.12.53.31.40.61.41.71.61.5-1.61.71.8-1.81.8
ShA late average infusions1.92.04.61.42.11.81.41.41.5-1.41.20.9-0.90.8
ShA early timeout1.11.11.90.7-0.11.01.01.01.1-1.01.21.3-1.41.4
ShA late timeout1.31.42.61.61.11.31.31.31.2-1.21.11.0-1.00.9
ShA early titration1.82.02.61.20.71.31.61.51.3-1.51.51.5-1.61.5
ShA late titration2.72.84.81.92.21.91.81.81.7-1.71.51.3-1.31.2
ShA total infusions3.84.75.92.22.42.42.32.32.2-2.22.11.8-1.91.8
One hour access (0.3 mA shock)1.51.83.7-1.9-1.2-1.5-1.4-1.4-1.41.3-1.1-1.01.1-1.0
Shock compulsivity0.10.21.70.31.30.40.40.30.2-0.40.1-0.20.1-0.2
Compulsive drug intake0.91.12.70.61.71.41.11.11.2-1.01.00.6-0.70.6
One hour access (shock baseline)1.11.83.5-1.9-1.4-1.6-1.4-1.4-1.51.3-1.0-0.91.0-0.9
Social response proportion0.40.52.00.1-1.4-0.10.40.30.1-0.30.50.8-0.90.9
Social responses0.40.53.30.0-1.8-0.50.00.0-0.20.00.20.7-0.70.8
Social time0.50.71.10.8-0.40.70.80.70.7-0.80.81.0-1.01.0
Soleus weight2.05.99.9-3.1-1.2-2.2-2.5-2.5-2.42.5-2.2-2.62.5-2.4
Bone: stiffness0.00.00.10.10.30.10.10.20.1-0.10.20.1-0.10.1
Tibialis anterior weight0.72.54.7-1.6-2.2-2.0-1.6-1.6-1.71.5-1.5-1.21.2-1.1
Time to tail flick, vehicle, before self-admin0.10.10.1-0.1-0.0-0.3-0.2-0.3-0.30.2-0.4-0.40.4-0.4
Time to tail flick, vehicle, after self-admin0.10.20.40.60.60.40.50.40.5-0.50.40.3-0.30.3
Time to tail flick, test, before self-admin0.30.30.7-0.80.3-0.1-0.6-0.5-0.40.6-0.5-0.70.6-0.7
Time to tail flick, test, after self-admin2.93.14.1-1.7-1.7-2.0-1.8-1.7-1.81.8-1.8-1.61.5-1.6
Delta time to tail flick, vehicle, before/after SA0.20.20.4-0.00.60.50.50.50.5-0.50.60.4-0.40.5
Delta time to tail flick, test, before/after SA0.20.21.50.0-1.2-0.8-0.2-0.2-0.50.2-0.30.1-0.10.1
Tibia length0.61.73.1-1.71.1-0.5-1.2-1.2-0.91.1-1.0-1.71.7-1.7
Ambulatory time before self-admin2.43.64.3-2.0-0.8-2.0-1.9-1.9-1.81.9-2.0-2.02.1-2.1
Ambulatory time after self-admin1.11.32.1-1.1-0.0-0.9-1.1-1.1-0.91.1-1.2-1.41.3-1.5
Bone: tissue strength0.00.00.2-0.4-0.1-0.00.10.10.0-0.00.20.0-0.20.1
Total heroin consumption0.00.00.10.00.2-0.1-0.0-0.1-0.00.0-0.1-0.00.1-0.1
Total infusions2.22.83.31.61.71.81.81.71.7-1.71.71.6-1.61.5
Bone: trabecular number0.20.40.7-0.20.2-0.5-0.6-0.6-0.60.6-0.7-0.70.8-0.8
Bone: trabecular spacing0.40.51.9-0.9-1.4-0.9-0.6-0.6-0.70.5-0.5-0.30.2-0.2
Bone: trabecular thickness0.30.42.40.71.50.70.30.30.5-0.30.1-0.10.2-0.2
Bone: trabecular tissue density1.42.12.81.40.51.31.51.41.4-1.61.51.6-1.71.6
Water consumed over 24 hours0.30.42.80.4-1.7-0.60.20.0-0.3-0.00.00.6-0.60.6
Number of responses in last shaping day0.10.10.20.30.40.40.30.30.3-0.20.30.3-0.20.2