Rgp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative TSS	NM_001399573.1	0.02	0.02	8.8e-03	0.02	0.02	0.01	0.02	1.8e-03	5.7e-03	7.5e-03	2.2e-03
2	Liver	alternative TSS	XM_039111010.2	0.02	0.02	9.3e-03	0.02	0.02	0.02	0.02	1.3e-03	6.6e-03	4.9e-03	1.6e-03
3	Liver	gene expression	Rgp1	0.03	0.03	4.3e-04	0.04	0.03	0.03	0.03	6.2e-05	6.2e-04	7.1e-04	3.5e-04
4	NAcc	gene expression	Rgp1	0.01	0.01	2.5e-03	0.01	0.01	0.01	0.01	1.9e-03	2.6e-03	2.8e-03	5.0e-03
5	Adipose	gene expression	Rgp1	0.03	0.02	1.2e-03	0.02	0.02	0.03	0.03	2.4e-03	1.3e-03	5.2e-04	7.1e-04
6	Brain	gene expression	Rgp1	0.03	0.02	1.9e-03	0.02	0.02	0	0.01	9.6e-03	4.4e-03	1.7e-01	6.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.5	2.6	3.7	-1.5	1.5	1.8	1.8	1.2	1.9
Area under the delay curve	0.6	0.7	1.1	0.6	-0.6	-1.0	-0.6	-0.9	-1.1
BMI with tail	1.6	5.4	6.5	-2.4	2.4	2.5	2.4	1.8	2.5
BMI without tail	2.1	6.3	6.9	-2.6	2.6	2.6	2.6	2.1	2.4
Body weight	2.8	12.3	17.3	-4.2	4.2	3.4	3.4	3.0	2.8
Weight adjusted by age	0.1	0.2	0.4	-0.6	0.6	0.2	0.1	0.3	-0.1
Bone surface	0.9	1.6	1.9	-1.4	1.4	1.3	1.2	1.0	1.2
Bone volume	0.7	1.3	1.7	-1.1	1.1	1.3	1.2	0.8	1.3
Breakpoint value in progressive ratio session	2.0	2.4	6.1	0.3	-0.3	-2.0	-1.8	-1.0	-2.5
Number of licking bursts	3.4	5.6	6.5	-2.3	2.3	2.5	2.5	2.0	2.4
Context. condit. distance diff. score	0.1	0.1	0.1	0.4	-0.4	-0.2	-0.2	-0.3	-0.0
Locomotion velocity, session 1	0.8	0.9	1.8	-1.2	1.2	-0.3	-0.4	0.4	-1.4
Locomotion distance, session 1	0.2	0.3	0.6	-0.8	0.8	-0.1	0.0	0.4	-0.6
Locomotion velocity, session 2	2.9	3.4	4.1	-1.7	1.7	2.0	2.0	1.6	1.9
Locomotion distance, session 2	1.5	2.2	3.2	-1.8	1.8	1.2	1.3	1.8	0.5
Locomotion velocity, session 3	0.2	0.2	0.6	-0.4	0.4	-0.4	-0.3	0.0	-0.8
Locomotion distance, session 3	1.5	1.7	3.0	-1.7	1.7	1.1	1.2	0.9	0.9
Stereotopy head waving bouts, day 3	0.4	0.5	1.8	-0.1	0.1	-0.7	-0.8	0.1	-1.3
Stereotopy head waving duration, day 3	0.4	0.4	1.2	0.3	-0.3	-0.7	-0.8	-0.2	-1.1
Locomotion velocity, session 7	0.1	0.1	0.1	0.3	-0.3	-0.4	-0.3	-0.4	-0.3
Locomotion distance, session 7	0.1	0.1	0.3	-0.6	0.6	0.3	0.2	0.3	0.1
Stereotopy head waving bouts, day 7	1.1	1.2	2.0	-1.4	1.4	1.0	0.9	1.0	0.6
Stereotopy head waving duration, day 7	0.6	0.7	1.1	-1.0	1.0	0.8	0.7	1.0	0.3
Locomotion velocity, session 8	0.2	0.2	0.9	-0.2	0.2	-0.4	-0.4	0.4	-1.0
Locomotion distance, session 8	0.1	0.2	0.4	-0.6	0.6	0.0	0.1	0.6	-0.4
Degree of sensitization distance	0.9	0.9	1.2	1.1	-1.1	-0.9	-1.0	-0.5	-1.0
Degree of sensitization stereotypy	1.2	1.3	1.6	-1.3	1.3	1.2	1.2	0.8	1.1
Conditioned locomotion	0.2	0.2	0.4	0.0	-0.0	-0.6	-0.5	-0.6	-0.7
Cocaine response after cond. corrected	2.4	2.8	4.4	1.3	-1.3	-1.9	-1.9	-1.4	-2.1
Cocaine response after cond. not corrected	2.0	2.4	5.0	1.0	-1.0	-1.7	-1.8	-1.0	-2.2
Cocaine response before conditioning	0.8	0.9	1.4	-1.0	1.0	1.0	0.9	1.2	0.7
Saline control response	0.4	0.6	1.1	-1.1	1.1	0.5	0.5	0.8	-0.1
Bone: connectivity density	1.0	1.5	2.5	-1.0	1.0	1.4	1.4	0.8	1.6
Bone: cortical apparent density	0.2	0.2	0.7	0.1	-0.1	0.6	0.4	0.2	0.8
Bone: cortical area	2.6	3.9	6.2	-1.5	1.5	2.1	2.4	1.6	2.5
Bone: cortical porosity	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.3	-0.2	-0.3
Bone: cortical porosity	0.0	0.0	0.0	-0.1	0.1	-0.0	-0.0	-0.1	-0.0
Bone: cortical thickness	1.0	1.6	4.4	-0.4	0.4	1.4	1.6	0.6	2.1
Bone: cortical thickness	0.3	0.3	0.7	0.8	-0.8	-0.4	-0.4	-0.4	0.1
Bone: cortical tissue density	0.1	0.1	0.5	0.2	-0.2	0.5	0.3	0.2	0.7
Condit. Reinf. active minus inactive responses	0.8	0.9	1.2	-0.9	0.9	1.0	0.9	1.1	0.8
Condit. Reinf. active-inactive response ratio	0.5	0.6	0.8	0.9	-0.9	-0.6	-0.8	-0.7	-0.5
Condit. Reinf. active responses	3.7	4.6	5.4	-2.1	2.1	2.3	2.2	2.3	1.9
Condit. Reinf. inactive responses	4.4	5.4	6.4	-2.2	2.2	2.5	2.5	2.3	2.2
Incentive salience index mean	5.1	6.2	7.2	-2.7	2.7	2.5	2.5	2.6	2.0
Condit. Reinf. lever presses	10.7	15.0	19.5	-4.4	4.4	3.8	3.8	3.8	2.8
Condit. Reinf. active minus inactive responses	0.7	0.9	1.3	-0.7	0.7	1.0	1.1	0.8	1.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.7	-0.1	0.1	0.5	0.6	0.1	0.8
Condit. Reinf. active responses	2.2	3.1	3.7	-1.7	1.7	1.8	1.9	1.7	1.7
Condit. Reinf. inactive responses	3.0	3.8	4.8	-1.9	1.9	2.1	2.2	1.8	1.9
Condit. Reinf. lever presses	3.5	4.8	6.2	-1.8	1.8	2.4	2.5	2.1	2.4
Condit. Reinf. lever reinforcers received	2.8	3.8	4.5	-1.9	1.9	2.0	2.1	1.9	1.8
Conditioned reinforcement - actives	0.0	0.0	0.1	-0.1	0.1	-0.2	0.1	-0.3	-0.0
Conditioned reinforcement - inactives	0.4	0.6	1.0	0.6	-0.6	-1.0	-0.8	-0.9	-0.8
Conditioned locomotion	0.1	0.2	0.6	-0.3	0.3	-0.3	-0.3	-0.7	-0.1
Patch foraging indifference point 0 sec	0.2	0.4	0.8	-0.9	0.9	-0.4	-0.1	-0.4	-0.7
Patch foraging indifference point AUC	8.0	11.6	14.9	-3.9	3.9	3.4	3.3	3.1	2.7
Delay disc. indifference point, 0s delay	1.1	1.2	2.2	0.8	-0.8	-1.3	-1.2	-0.9	-1.5
Delay disc. indifference point, 16s delay	1.7	1.9	3.0	0.8	-0.8	-1.6	-1.5	-1.4	-1.7
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	-0.1	0.1	0.4	0.5	0.0	0.5
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	0.4	-0.4	-0.3	-0.1	-0.2	-0.3
Delay disc. indifference point, 4s delay	0.1	0.1	0.4	0.2	-0.2	-0.3	-0.2	-0.6	-0.4
Delay disc. indifference point, 8s delay	0.0	0.1	0.3	-0.1	0.1	0.1	0.5	0.2	0.1
Indifference point function ln k	2.5	4.4	4.9	2.2	-2.2	-2.2	-2.1	-2.0	-1.9
Indifference point function log k	2.5	4.4	4.9	2.2	-2.2	-2.2	-2.1	-2.0	-1.9
Patch foraging total patch changes 0 sec	0.3	0.6	1.7	-1.3	1.3	0.0	0.3	-0.0	-0.2
Patch foraging total patch changes 12 sec	2.1	2.7	3.3	-1.8	1.8	1.6	1.7	1.0	1.7
Patch foraging total patch changes 18 sec	0.6	0.9	1.5	-1.2	1.2	0.9	1.0	0.7	0.6
Patch foraging total patch changes 24 sec	1.7	3.0	4.5	-2.1	2.1	1.6	1.6	1.4	1.3
Patch foraging total patch changes 6 sec	2.0	3.1	5.6	-2.4	2.4	1.4	1.7	1.2	1.0
Patch foraging time to switch 0 sec	2.0	4.1	6.3	2.5	-2.5	-1.9	-1.8	-1.9	-1.3
Patch foraging water rate 0 sec	0.9	2.0	3.6	-1.9	1.9	1.2	1.2	0.9	1.0
Patch foraging water rate 12 sec	0.0	0.0	0.1	-0.0	0.0	-0.2	-0.2	0.0	-0.3
Patch foraging water rate 18 sec	0.3	0.4	1.3	-0.3	0.3	0.6	0.7	0.3	1.1
Patch foraging water rate 24 sec	0.1	0.2	0.6	0.4	-0.4	0.3	0.1	-0.2	0.8
Patch foraging water rate 6 sec	0.4	0.6	1.0	-0.8	0.8	0.7	0.4	1.0	0.5
Seeking ratio, delayed vs. immediate footshock	3.3	4.0	6.7	-2.0	2.0	2.0	2.6	1.2	2.1
Distance traveled before self-admin	2.5	3.2	5.7	-2.4	2.4	1.5	1.3	1.7	0.9
Distance traveled after self-admin	1.2	1.5	2.1	-1.0	1.0	1.4	1.1	1.4	1.2
Extensor digitorum longus weight	4.6	18.2	22.6	-4.8	4.8	4.2	4.4	3.7	3.7
Bone: elastic displacement	5.4	6.2	8.4	2.9	-2.9	-2.3	-2.4	-2.8	-1.4
Bone: elastic work	1.9	2.4	4.8	2.2	-2.2	-0.9	-0.8	-1.9	0.3
Bone: endosteal estimation	1.1	2.4	3.5	-1.9	1.9	1.4	1.3	1.7	0.8
Bone: endosteal perimeter	0.9	1.9	3.0	-1.7	1.7	1.2	1.3	1.5	0.7
Epididymis fat weight	0.5	1.7	2.1	-1.2	1.2	1.4	1.4	1.3	1.2
Delta time in closed arm before/after self-admin	0.8	0.8	1.5	-0.3	0.3	1.0	1.2	0.5	1.2
Delta time in open arm before/after self-admin	0.4	0.4	0.8	0.4	-0.4	-0.9	-0.4	-0.4	-0.9
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	0.5	-0.5	0.1	0.1	0.1	0.1
Delay discount exponential model param	0.5	0.6	0.9	-0.5	0.5	0.9	0.6	0.8	1.0
Extinction: sum of active levers before priming	3.6	3.9	5.3	2.0	-2.0	-2.3	-1.8	-1.5	-2.2
Active lever presses in extinction session 6	0.4	0.4	0.5	0.6	-0.6	-0.7	-0.6	-0.7	-0.5
Bone: final force	1.6	2.5	3.2	-1.4	1.4	1.6	1.8	1.7	1.4
Bone: final moment	1.3	2.1	2.9	-1.2	1.2	1.6	1.7	1.6	1.4
Food consumed during 24 hour testing period	0.5	0.7	1.0	-1.0	1.0	0.8	0.8	1.0	0.4
Glucose	2.5	3.9	4.8	-2.2	2.2	2.0	2.1	1.7	1.7
Heart weight	0.8	1.3	2.1	-1.1	1.1	1.1	1.4	1.1	0.9
Delay discount hyperbolic model param	0.3	0.4	0.7	-0.4	0.4	0.8	0.4	0.7	0.8
Intermittent access intake day 1-15 change	0.5	1.0	1.6	-0.9	0.9	1.2	1.1	0.7	1.3
Intermittent access intake escalation	0.4	0.9	1.5	-0.7	0.7	1.2	1.0	0.7	1.2
Intermittent access intake escalation 2	1.4	1.6	3.4	-0.7	0.7	1.5	1.5	0.8	1.8
Intermitt. access day 1 inactive lever presses	0.3	1.3	1.7	-1.3	1.3	1.0	1.1	1.3	0.8
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.0	-0.1	0.1	-0.1	0.2	0.0	-0.2
Intermitt. access escalation Index	0.4	0.5	0.9	-1.0	1.0	0.6	0.3	0.8	0.2
Intermittent access day 1 total infusions	1.7	2.7	4.1	1.1	-1.1	-2.0	-1.6	-1.9	-1.8
Intermittent access day 15 total infusions	0.0	0.1	0.2	-0.1	0.1	0.0	0.2	-0.5	0.4
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.2	-0.2	0.2	-0.0	0.1	-0.4	0.3
Intermittent access total infusions	0.1	0.1	0.5	-0.2	0.2	-0.3	-0.0	-0.7	-0.0
Intermittent access day 1 locomotion	1.6	2.0	3.1	1.0	-1.0	-1.8	-1.4	-1.8	-1.4
Intermittent access day 15 total locomotion	1.0	1.9	3.4	1.1	-1.1	-1.6	-1.3	-1.8	-1.1
Intermittent access total locomotion	1.6	1.9	3.5	1.4	-1.4	-1.4	-1.1	-1.9	-0.8
Intermittent access standard deviation	0.1	0.2	0.4	-0.5	0.5	0.3	0.6	0.0	0.5
Left kidney weight	0.4	1.8	3.3	-1.8	1.8	0.9	1.1	1.3	0.3
Right kidney weight	0.4	1.9	2.2	-1.5	1.5	1.3	1.5	1.4	1.0
Cocaine induced anxiety	0.1	0.2	0.4	0.4	-0.4	-0.3	-0.7	-0.3	-0.5
Post-drug Anxiety	0.5	0.5	1.0	-1.0	1.0	0.6	0.4	0.8	-0.0
Baseline Anxiety	0.9	1.0	1.5	-0.9	0.9	1.0	1.2	1.2	0.8
Tail length	1.8	6.9	8.4	-2.9	2.9	2.6	2.6	2.7	1.9
Length with tail	1.2	5.2	8.8	-3.0	3.0	1.9	2.0	2.2	1.1
Length without tail	0.1	0.2	0.6	-0.6	0.6	-0.4	-0.2	0.1	-0.8
Times rat made contact with spout	0.4	0.5	1.0	-0.5	0.5	0.7	0.7	0.3	1.0
Lifetime Intake	0.2	0.3	0.7	-0.2	0.2	-0.6	-0.3	-0.8	-0.4
Liver weight, left	0.0	0.1	0.2	0.1	-0.1	-0.3	-0.1	0.2	-0.5
Liver weight, right	0.8	1.4	2.0	1.4	-1.4	-1.2	-1.0	-1.2	-0.8
Locomotor activity	0.0	0.0	0.1	-0.1	0.1	-0.0	0.0	0.4	-0.1
Locomotor testing distance	0.3	0.5	1.3	0.2	-0.2	-0.9	-0.8	-0.2	-1.1
Locomotor testing rearing	0.4	0.8	1.3	-1.1	1.1	0.6	0.6	1.1	0.2
Locomotion in novel chamber	0.3	0.3	0.6	0.8	-0.8	-0.2	-0.1	-0.7	0.3
Locomotion in novel chamber post-restriction	1.5	2.4	4.2	-1.0	1.0	1.9	1.8	1.1	2.0
Fecal boli incidents, locomotor time 1	0.4	0.6	1.1	1.1	-1.1	-0.6	-0.3	-0.8	-0.3
Change in fecal boli incidents, locomotor task	0.5	0.5	1.1	-1.1	1.1	0.5	-0.1	0.6	0.1
Time >=10cm from walls, locomotor time 1	0.1	0.2	0.3	-0.3	0.3	-0.4	-0.4	-0.2	-0.6
Bouts of movement, locomotor time 1	1.5	1.7	2.2	1.5	-1.5	-1.2	-1.3	-1.1	-1.2
Total resting periods, locomotor time 1	1.9	2.1	3.3	1.8	-1.8	-1.3	-1.3	-1.2	-1.0
Rest time, locomotor task time 1	0.7	0.9	2.6	1.6	-1.6	-0.1	-0.4	-0.4	0.3
Distance moved, locomotor task time 1	1.0	1.4	3.6	-1.9	1.9	0.6	0.5	0.9	0.1
Vertical activity count, locomotor time 1	0.4	1.0	2.4	-1.6	1.6	0.0	-0.2	0.7	-0.7
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.3	0.3	0.1	0.5	0.3	-0.1
Bouts of movement, locomotor time 2	0.4	0.6	0.8	-0.9	0.9	0.7	0.9	0.7	0.6
Total resting periods, locomotor time 2	0.1	0.2	0.3	-0.4	0.4	0.4	0.6	0.4	0.4
Rest time, locomotor task time 2	0.7	0.8	1.3	1.1	-1.1	-0.7	-1.1	-0.6	-0.5
Distance moved, locomotor task time 2	0.6	0.8	1.1	-0.7	0.7	1.0	1.0	0.9	0.9
Vertical activity count, locomotor time 2	0.4	0.6	1.1	-1.0	1.0	0.7	0.5	0.9	0.2
Light reinforcement 1	0.4	1.0	1.8	-1.4	1.4	-0.3	-0.1	1.0	-1.2
Light reinforcement 2	0.7	1.1	2.9	-1.0	1.0	-0.7	-0.9	0.5	-1.7
Bone: marrow area	1.2	2.7	3.7	-1.9	1.9	1.6	1.5	1.7	1.0
Bone: maximum diameter	2.6	4.9	6.2	-2.1	2.1	2.3	2.5	2.0	2.3
Bone: maximum force	3.2	5.7	7.2	-2.2	2.2	2.5	2.7	2.5	2.3
Bone: maximum moment	2.7	4.7	6.2	-1.9	1.9	2.3	2.5	2.2	2.2
Mean time between licks in bursts	0.2	0.5	0.8	0.7	-0.7	-0.7	-0.7	0.0	-0.9
Mean num. licks in bursts	1.6	2.4	2.7	1.6	-1.6	-1.6	-1.6	-1.4	-1.4
Cd content in liver	0.6	0.7	1.1	-1.0	1.0	0.8	0.5	1.0	0.4
Co content in liver	1.0	1.1	1.8	0.8	-0.8	-1.3	-1.2	-0.7	-1.4
Cu content in liver	1.6	1.9	2.5	1.6	-1.6	-1.3	-1.5	-0.9	-1.3
Fe content in liver	1.6	1.9	3.4	1.1	-1.1	-1.7	-1.5	-0.9	-1.8
K content in liver	0.4	0.4	0.8	0.3	-0.3	-0.7	-0.8	-0.4	-0.9
Mg content in liver	0.6	0.6	0.8	0.7	-0.7	-0.9	-0.8	-0.9	-0.7
Mn content in liver	1.5	1.7	2.4	-1.0	1.0	1.5	1.5	1.0	1.5
Na content in liver	1.8	1.9	2.4	1.6	-1.6	-1.4	-1.4	-0.7	-1.4
Rb content in liver	7.0	8.1	9.1	3.0	-3.0	-3.0	-2.9	-2.6	-2.5
Se content in liver	3.6	4.3	5.2	-1.9	1.9	2.3	2.1	2.3	1.8
Sr content in liver	1.4	1.2	1.8	-1.3	1.3	1.0	1.0	1.3	0.5
Zn content in liver	0.1	0.1	0.2	-0.1	0.1	0.3	0.3	0.5	0.3
Bone: minimum diameter	0.0	0.1	0.1	0.2	-0.2	0.1	0.2	0.0	0.4
Time in familiar zone, hab. session 1	0.6	0.6	1.4	0.9	-0.9	0.3	0.2	-0.6	1.2
Time in novel zone, hab. session 1	2.8	2.8	7.3	0.9	-0.9	-1.9	-1.9	-0.7	-2.7
Total zone transitions, hab. session 1	0.0	0.0	0.1	-0.1	0.1	0.2	0.2	0.3	0.0
Total locomotion distance, hab. session 1	0.8	1.1	1.7	-0.6	0.6	1.3	1.2	1.1	1.3
Locomotion velocity, hab. session 1	2.3	3.3	4.2	-1.5	1.5	2.1	2.0	1.8	1.9
Time in familiar zone, hab. session 2	0.4	0.4	1.1	1.0	-1.0	-0.2	-0.3	-0.5	0.3
Time in novel zone, hab. session 2	2.1	2.1	3.9	0.9	-0.9	-1.7	-1.7	-1.3	-2.0
Total zone transitions, hab. session 2	0.4	0.5	1.0	-1.0	1.0	0.5	0.5	0.9	0.1
Total locomotion distance, hab. session 2	1.0	1.3	1.7	-1.2	1.2	1.2	1.1	1.3	0.9
Locomotion velocity, hab. session 2	1.3	1.7	2.0	-1.4	1.4	1.4	1.3	1.4	1.1
Novel to familiar place preference ratio	4.2	4.6	6.1	1.8	-1.8	-2.5	-2.3	-1.9	-2.5
Novelty place preference	5.6	6.0	7.5	2.2	-2.2	-2.7	-2.6	-2.2	-2.6
Time in novel zone, NPP test	6.8	7.3	9.1	2.5	-2.5	-3.0	-2.9	-2.4	-2.9
Total zone transitions, NPP test	0.6	0.8	1.5	-1.2	1.2	0.6	0.6	1.2	-0.0
Total locomotion distance, NPP test	1.9	2.5	3.9	-2.0	2.0	1.4	1.4	1.7	0.8
Locomotion velocity, NPP test	2.5	3.5	4.9	-2.2	2.2	1.8	1.7	1.9	1.3
Intraocular pressure	2.0	2.8	4.8	-2.2	2.2	1.6	1.4	1.1	1.3
Delta distance traveled before/after self-admin	0.1	0.1	0.2	0.5	-0.5	0.1	-0.1	0.3	0.1
Delta ambulatory time before/after self-admin	0.4	0.5	1.2	1.1	-1.1	-0.4	-0.6	-0.0	-0.4
Parametrial fat weight	0.2	0.4	1.2	0.2	-0.2	-0.8	-0.8	-0.3	-1.1
Pavlov. Cond. lever latency	7.2	9.1	11.4	3.4	-3.4	-3.0	-2.9	-3.0	-2.3
Pavlov. Cond. magazine entry latency	0.8	1.0	1.5	-1.0	1.0	1.0	1.0	1.2	0.7
Pavlov. Cond. change in total contacts	2.9	3.1	4.0	-2.0	2.0	1.7	1.6	1.8	1.3
Pavlov. Cond. index score	3.9	4.9	5.4	-2.3	2.3	2.3	2.2	2.3	1.8
Pavlov. Cond. latency score	3.5	4.5	5.0	-2.2	2.2	2.2	2.1	2.2	1.7
Pavlov. Cond. lever contacts	6.9	8.2	9.9	-3.1	3.1	2.9	2.8	2.7	2.3
Pavlov. Cond. magazine entry number	0.9	1.1	1.3	1.0	-1.0	-1.2	-1.1	-1.1	-1.0
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.5	-0.6	0.6	0.7	0.6	0.7	0.5
Pavlov. Cond. lever-magazine prob. diff.	4.0	5.0	5.5	-2.3	2.3	2.3	2.3	2.3	1.9
Pavlov. Cond. response bias	4.5	5.5	6.4	-2.5	2.5	2.4	2.3	2.4	1.9
Pavlov. Cond. lever latency	3.3	4.5	5.5	1.8	-1.8	-2.3	-2.3	-2.1	-2.2
Pavlov. Cond. magazine entry latency	0.2	0.2	0.4	0.7	-0.7	-0.3	-0.2	-0.1	-0.2
Pavlov. Cond. change in total contacts	1.2	2.0	3.3	-0.7	0.7	1.7	1.6	1.4	1.8
Pavlov. Cond. index score	0.5	0.7	1.2	-0.3	0.3	1.0	1.0	0.9	1.1
Pavlov. Cond. latency score	0.7	0.9	1.8	-0.4	0.4	1.2	1.2	0.9	1.3
Pavlov. Cond. lever contacts	2.6	3.5	4.4	-1.6	1.6	2.1	2.1	1.9	2.0
Pavlov. Cond. magazine entry number	0.3	0.4	1.1	-0.1	0.1	-0.8	-0.8	-0.5	-1.0
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.4	-0.6	0.6	0.4	0.5	0.2	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.4	-0.3	0.3	1.1	1.1	0.9	1.2
Pavlov. Cond. response bias	1.3	1.8	2.5	-0.9	0.9	1.5	1.6	1.5	1.5
Time in closed arm before self-admin	0.4	0.5	1.3	0.7	-0.7	-0.6	-0.7	-1.1	-0.3
Time in closed arm after self-admin	0.2	0.2	0.5	0.7	-0.7	0.1	-0.2	-0.5	0.5
Time in open arm before self-admin	1.0	1.1	1.9	-1.4	1.4	0.7	0.6	1.3	0.2
Time in open arm after self-admin	0.7	0.8	1.6	-1.3	1.3	0.4	0.8	0.7	0.1
Bone: periosteal estimation	1.8	3.7	4.3	-1.9	1.9	2.0	2.1	1.9	1.8
Bone: periosteal perimeter	0.4	0.7	0.9	-0.9	0.9	0.7	0.9	0.8	0.6
Bone: post-yield work	2.2	3.2	4.6	-2.1	2.1	1.6	1.6	2.0	0.9
Progressive ratio test 1 active lever presses	1.1	1.3	2.2	0.5	-0.5	-1.5	-1.2	-1.5	-1.3
Progressive ratio test 1 breakpoint	0.9	1.1	1.9	0.4	-0.4	-1.4	-1.1	-1.4	-1.1
Progressive ratio test 1 inactive lever presses	0.4	0.5	1.4	-1.2	1.2	-0.0	0.2	0.3	-0.4
Progressive ratio test 2 active lever presses	1.4	1.6	2.9	0.6	-0.6	-1.7	-1.3	-1.5	-1.5
Progressive ratio test 2 breakpoint	1.5	1.8	3.0	0.6	-0.6	-1.7	-1.4	-1.5	-1.6
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.1	-0.3	0.3	-0.1	0.1	-0.3	0.1
Incentive Sensitization - Responses	0.5	0.7	1.3	0.5	-0.5	-1.1	-0.9	-0.8	-1.1
Incentive Sensitization - Breakpoint	0.6	0.8	1.4	0.6	-0.6	-1.2	-0.9	-0.9	-1.1
Sum of active levers in priming session hrs 5-6	3.9	3.7	5.2	1.5	-1.5	-2.3	-2.1	-1.6	-2.3
Progressive ratio	0.0	0.0	0.1	0.1	-0.1	-0.2	0.2	-0.3	-0.1
Food seeking constrained by brief footshock	5.7	7.0	12.1	-3.5	3.5	2.2	2.4	2.1	1.6
Seeking ratio, punishment vs. effort	1.6	2.3	3.6	-1.9	1.9	1.5	1.2	1.4	1.1
Retroperitoneal fat weight	0.3	1.4	2.4	1.6	-1.6	-1.1	-0.9	-1.0	-0.7
Reaction time number correct	0.0	0.1	0.2	-0.4	0.4	-0.1	0.2	0.3	-0.1
Reaction time mean minus median	0.5	1.3	3.7	-0.1	0.1	1.3	1.6	0.4	1.9
Reaction time mean minus median AUC	0.7	1.8	3.9	-0.6	0.6	1.5	1.9	0.7	2.0
Reaction time num false alarms	0.1	0.2	0.3	-0.1	0.1	0.5	0.6	0.1	0.6
Reaction time num false alarms AUC	0.3	0.5	0.8	-0.7	0.7	0.7	0.9	0.3	0.7
Reaction time trials correct on left	0.0	0.1	0.2	-0.4	0.4	-0.1	0.2	0.3	-0.1
Reaction time trials on left	0.0	0.0	0.1	-0.3	0.3	-0.2	0.1	0.3	-0.1
Reaction time mean	0.9	1.5	3.3	1.8	-1.8	-0.6	-0.6	-1.2	0.0
Reaction time mean AUC	1.0	1.6	3.7	1.9	-1.9	-0.7	-0.6	-1.2	-0.0
Median of all reaction times	2.4	3.4	5.7	2.4	-2.4	-1.5	-1.6	-1.8	-1.0
Reaction time omissions	1.6	2.3	2.6	1.6	-1.6	-1.4	-1.5	-1.6	-1.4
Reaction time false alarm rate	0.1	0.1	0.1	0.1	-0.1	0.3	0.3	-0.3	0.3
Reaction time premature initiation rate	2.3	3.1	4.7	2.2	-2.2	-1.5	-1.5	-2.1	-0.7
Reaction time premature initiations	1.3	2.3	3.3	1.8	-1.8	-1.4	-1.3	-1.8	-0.7
Std. dev. reaction times	0.2	0.4	1.0	0.7	-0.7	0.5	0.6	-0.2	1.0
Reaction time trials completed	0.0	0.0	0.1	-0.3	0.3	-0.2	0.1	0.3	-0.1
Reaction time trials AUC	0.0	0.0	0.1	-0.3	0.3	-0.2	0.1	0.2	-0.1
Run reversals in cocaine runway, females	0.2	0.2	0.4	-0.1	0.1	0.6	0.4	0.3	0.6
Run reversals in cocaine runway, males	0.1	0.1	0.1	0.3	-0.3	-0.3	0.1	-0.3	-0.1
Latency to leave start box in cocaine runway	0.6	0.6	0.9	-0.8	0.8	0.9	0.8	0.6	0.9
Latency to leave start box in cocaine runway, F	0.1	0.2	0.2	0.2	-0.2	-0.5	-0.4	-0.5	-0.4
Latency to leave start box in cocaine runway, M	2.2	2.0	2.7	-1.6	1.6	1.5	1.3	1.2	1.2
Std. dev. time between licks in bursts	0.2	0.3	0.4	0.6	-0.6	-0.6	-0.6	-0.4	-0.5
Total sessions with >9 infusions	0.3	0.4	0.9	-0.3	0.3	-0.8	-0.7	-0.5	-0.9
Short access day 1 total inactive lever presses	0.3	0.3	0.9	-1.0	1.0	-0.0	-0.2	0.1	-0.2
Short access day 10 total inactive lever presses	0.3	0.8	0.9	-0.8	0.8	1.0	0.9	0.9	0.9
Short access day 1 total infusions	0.4	0.5	1.0	-0.4	0.4	-0.9	-0.7	-0.6	-1.0
Short access day 10 total infusions	0.5	0.7	1.3	-0.1	0.1	-1.0	-1.0	-0.8	-1.1
Short access total infusions	0.9	1.1	2.1	0.1	-0.1	-1.4	-1.2	-1.1	-1.4
Short access day 1 locomotion	1.8	2.2	3.8	1.1	-1.1	-1.9	-1.5	-1.7	-1.6
Short access day 10 total locomotion	0.5	1.0	1.5	1.2	-1.2	-0.9	-0.6	-1.2	-0.4
Short access total locomotion	0.6	0.7	1.2	0.4	-0.4	-1.1	-1.0	-0.9	-1.0
One hour access (0.3 mA shock)	0.1	0.2	0.4	-0.7	0.7	-0.1	0.1	-0.3	-0.2
Compulsive drug intake	0.5	0.6	1.5	-0.3	0.3	0.8	1.2	0.5	1.0
One hour access (shock baseline)	0.3	0.4	0.8	-0.4	0.4	-0.8	-0.6	-0.8	-0.9
Social response proportion	1.5	1.7	2.8	1.7	-1.7	-1.1	-1.5	-0.7	-1.0
Social responses	0.8	1.1	1.4	-1.1	1.1	1.1	0.9	1.2	0.8
Social time	0.2	0.2	0.6	0.2	-0.2	-0.2	-0.4	0.7	-0.8
Soleus weight	0.3	1.0	3.7	-0.6	0.6	-0.9	-0.9	0.2	-1.9
Bone: stiffness	4.4	7.1	9.3	-2.5	2.5	2.8	2.8	3.1	2.2
Tibialis anterior weight	6.9	23.3	31.8	-5.6	5.6	4.6	4.7	4.5	3.6
Time to tail flick, vehicle, before self-admin	0.5	0.5	1.7	0.8	-0.8	-0.5	-0.4	-1.3	-0.0
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.4	0.0	-0.0	0.1	0.6	-0.5	0.5
Time to tail flick, test, before self-admin	0.5	0.5	0.7	-0.8	0.8	0.8	0.7	0.4	0.7
Time to tail flick, test, after self-admin	3.1	3.2	5.8	-1.3	1.3	2.0	2.2	1.1	2.4
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	-0.4	0.4	0.4	0.6	0.7	0.2
Delta time to tail flick, test, before/after SA	0.2	0.2	0.5	0.3	-0.3	0.3	0.4	-0.0	0.7
Tibia length	0.2	0.5	1.8	-0.0	0.0	-0.8	-0.7	0.3	-1.3
Ambulatory time before self-admin	1.6	2.3	4.5	-2.1	2.1	1.2	1.1	1.4	0.7
Ambulatory time after self-admin	0.4	0.5	1.1	-0.7	0.7	0.6	0.3	1.0	0.3
Bone: tissue strength	0.2	0.2	0.7	-0.2	0.2	0.4	0.6	0.9	0.2
Total heroin consumption	2.1	2.4	4.4	1.0	-1.0	-1.9	-1.7	-1.3	-2.1
Bone: trabecular number	1.5	2.4	3.1	-1.4	1.4	1.8	1.7	1.3	1.7
Bone: trabecular spacing	0.0	0.0	0.1	0.2	-0.2	0.0	0.0	-0.1	0.3
Bone: trabecular thickness	0.0	0.0	0.1	0.2	-0.2	0.1	0.0	-0.2	0.1
Bone: trabecular tissue density	3.2	4.7	6.9	-2.4	2.4	2.1	1.9	2.6	1.3
Water consumed over 24 hours	0.6	0.8	1.4	-0.9	0.9	1.0	1.0	0.5	1.2
Number of responses in last shaping day	1.3	1.5	4.0	-0.2	0.2	-1.4	-1.6	-0.6	-2.0