Hub : Genes

Rfx7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL mRNA stability Rfx7 0.19 0.11 4.7e-03 0.08 0.1 0.08 0.06 6.0e-03 1.8e-03 7.0e-03 1.8e-02
2 Liver mRNA stability Rfx7 0.1 0.1 1.6e-04 0.03 0.01 0.03 0.02 4.6e-04 7.8e-03 1.1e-04 1.5e-03
3 OFC mRNA stability Rfx7 0.38 0.16 2.2e-05 0.19 0.21 0.2 0.19 3.4e-05 1.2e-05 2.1e-05 2.4e-05
4 PL mRNA stability Rfx7 0.04 0.03 2.6e-04 0.04 0.04 0.04 0.04 9.1e-05 3.7e-05 5.3e-05 5.4e-05
5 PL gene expression Rfx7 0.03 0.02 1.4e-03 0.03 0.03 0.03 0.03 3.1e-04 5.6e-04 5.9e-04 2.0e-04
6 BLA gene expression Rfx7 0.12 0.07 1.7e-05 0.1 0.07 0.06 0.08 8.1e-06 2.1e-04 2.6e-04 4.9e-05
7 LHb mRNA stability Rfx7 0.19 0.13 9.0e-03 0.09 0.05 0.04 0.07 4.7e-03 2.2e-02 5.1e-02 1.0e-02
8 NAcc gene expression Rfx7 0.03 0.02 5.4e-05 0.02 0.02 0.01 0.01 2.9e-04 7.0e-04 2.8e-03 2.0e-03
9 Adipose gene expression Rfx7 0.06 0.06 8.5e-04 0.03 0.01 0.03 0.02 8.2e-04 4.9e-02 6.7e-04 4.5e-03
10 Eye isoform ratio NM_001127490.2 0.28 0.16 8.5e-03 0.11 0.11 0.1 0.16 8.7e-03 8.9e-03 1.1e-02 1.9e-03
11 Eye isoform ratio XM_006243326.5 0.29 0.14 1.5e-03 0.06 0.18 0.16 0.1 4.7e-02 9.9e-04 2.1e-03 1.2e-02
12 Adipose isoform ratio XM_039081516.2 0.1 0.07 2.9e-04 0.01 0.02 0.02 0.01 2.0e-02 1.2e-03 4.2e-03 2.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.20.40.90.8-0.10.90.80.80.60.70.90.5-0.10.20.5
Area under the delay curve0.80.91.70.20.60.70.81.10.70.91.11.3-1.31.30.9
BMI with tail1.75.922.8-4.8-0.1-2.7-2.3-1.0-1.1-1.1-1.01.5-4.33.1-1.1
BMI without tail0.62.07.5-2.70.4-1.8-1.7-1.2-1.0-1.0-1.3-0.2-1.51.0-1.2
Body weight1.04.215.0-3.80.1-1.5-1.2-0.10.30.10.01.9-3.93.6-0.0
Weight adjusted by age2.23.48.8-3.0-0.9-2.5-2.4-1.5-1.9-2.2-2.0-0.5-0.90.2-1.8
Bone surface0.00.00.1-0.3-0.3-0.2-0.2-0.1-0.2-0.1-0.10.10.10.0-0.3
Bone volume0.10.10.3-0.2-0.50.10.10.40.10.20.30.6-0.40.40.1
Breakpoint value in progressive ratio session0.10.10.5-0.20.60.0-0.0-0.70.30.2-0.2-0.4-0.20.2-0.0
Number of licking bursts0.50.82.81.30.90.30.2-0.4-0.3-0.3-0.2-1.21.7-1.5-0.6
Context. condit. distance diff. score1.01.22.70.7-0.50.91.01.61.11.21.21.6-0.60.81.1
Locomotion velocity, session 13.03.25.6-1.9-0.0-2.2-2.2-2.4-1.9-2.0-2.1-1.80.0-1.0-1.9
Locomotion distance, session 10.30.41.10.20.1-0.5-0.4-0.8-0.7-0.8-0.6-1.00.3-1.0-0.6
Locomotion velocity, session 20.20.31.4-0.41.2-0.2-0.5-0.5-0.2-0.3-0.8-0.4-0.4-0.3-0.1
Locomotion distance, session 20.30.50.8-0.50.3-0.6-0.7-0.9-0.7-0.9-0.9-0.9-0.1-0.6-0.7
Locomotion velocity, session 32.12.45.2-0.2-0.5-1.0-1.3-1.9-1.6-1.7-1.9-2.31.6-2.1-1.2
Locomotion distance, session 30.60.72.31.50.10.70.6-0.1-0.0-0.00.1-1.01.4-1.3-0.1
Stereotopy head waving bouts, day 30.50.61.1-1.0-0.8-1.0-0.9-0.8-0.9-0.9-0.7-0.3-0.5-0.1-0.5
Stereotopy head waving duration, day 30.80.92.0-1.4-1.1-1.4-1.3-0.9-1.0-1.1-0.9-0.2-0.6-0.0-0.5
Locomotion velocity, session 70.30.41.21.1-0.40.60.50.70.50.50.20.20.6-0.50.7
Locomotion distance, session 70.40.52.11.1-0.10.40.20.1-0.10.0-0.3-0.61.5-1.3-0.1
Stereotopy head waving bouts, day 71.01.21.9-1.2-0.1-1.3-1.3-1.4-1.3-1.3-1.1-1.10.2-0.4-1.1
Stereotopy head waving duration, day 71.72.03.2-1.3-0.4-1.5-1.6-1.8-1.6-1.7-1.6-1.60.7-1.0-1.4
Locomotion velocity, session 80.60.71.5-0.70.2-0.6-0.9-1.1-0.8-0.8-1.2-1.00.6-0.9-0.7
Locomotion distance, session 80.20.20.70.70.80.60.40.60.20.30.20.10.7-0.50.0
Degree of sensitization distance0.00.00.10.2-0.20.0-0.00.20.10.1-0.20.20.3-0.30.2
Degree of sensitization stereotypy0.91.01.5-1.1-0.2-1.1-1.1-1.2-1.2-1.2-1.0-1.00.2-0.4-1.1
Conditioned locomotion2.12.44.60.20.21.01.11.81.61.61.42.1-2.12.01.8
Cocaine response after cond. corrected2.02.45.9-2.4-1.9-2.1-2.0-1.3-1.4-1.5-1.6-0.1-1.30.2-0.8
Cocaine response after cond. not corrected1.41.64.1-2.0-1.5-1.8-1.6-1.0-1.1-1.2-1.30.1-1.20.3-0.7
Cocaine response before conditioning0.91.12.81.11.71.11.21.11.01.11.20.60.20.50.6
Saline control response0.91.22.1-0.5-0.2-1.1-1.2-1.3-1.4-1.4-1.2-1.30.8-1.3-0.8
Bone: connectivity density0.40.71.71.30.80.80.5-0.1-0.2-0.10.2-1.11.3-1.3-0.2
Bone: cortical apparent density0.10.10.80.9-0.30.30.30.20.10.00.1-0.10.4-0.60.2
Bone: cortical area0.91.48.4-0.6-2.9-0.5-0.30.60.30.30.01.5-1.60.91.3
Bone: cortical porosity1.11.22.11.20.61.21.21.41.31.31.01.1-0.40.51.4
Bone: cortical porosity2.62.84.41.60.81.91.82.12.12.01.71.7-0.51.02.0
Bone: cortical thickness0.81.47.90.8-2.80.40.71.00.70.70.81.2-0.80.41.6
Bone: cortical thickness0.50.63.40.5-1.80.30.30.60.60.50.20.9-0.40.11.2
Bone: cortical tissue density0.10.20.80.9-0.00.30.30.10.00.00.1-0.20.5-0.70.1
Condit. Reinf. active minus inactive responses2.22.55.11.22.31.81.81.81.91.91.71.2-0.11.30.8
Condit. Reinf. active-inactive response ratio2.72.85.01.10.81.61.82.22.01.92.02.1-0.61.61.5
Condit. Reinf. active responses0.70.84.60.62.21.10.90.50.90.80.6-0.10.70.3-0.2
Condit. Reinf. inactive responses1.92.35.9-0.31.0-0.6-1.0-1.8-1.4-1.3-1.5-2.41.7-1.8-1.9
Incentive salience index mean2.53.14.71.02.21.91.82.12.22.11.81.7-0.51.71.1
Condit. Reinf. lever presses1.62.33.80.81.61.61.51.91.91.91.41.6-0.61.41.2
Condit. Reinf. active minus inactive responses0.30.42.1-1.40.2-0.5-0.6-0.1-0.0-0.4-0.10.5-0.30.8-0.7
Condit. Reinf. active-inactive response ratio0.40.51.6-1.3-1.0-0.6-0.50.20.1-0.2-0.01.0-0.71.0-0.0
Condit. Reinf. active responses0.40.61.6-0.91.20.10.10.70.60.30.61.1-0.61.3-0.3
Condit. Reinf. inactive responses0.81.15.90.82.41.11.11.00.80.91.10.30.10.4-0.1
Condit. Reinf. lever presses0.60.92.00.7-0.50.80.91.41.20.91.01.3-0.10.61.1
Condit. Reinf. lever reinforcers received0.50.71.9-0.70.90.30.30.90.80.50.81.2-0.81.40.1
Conditioned reinforcement - actives0.10.10.6-0.2-0.8-0.3-0.3-0.3-0.2-0.2-0.2-0.10.1-0.2-0.0
Conditioned reinforcement - inactives0.30.53.2-0.3-1.8-0.7-0.6-0.4-1.0-0.5-0.5-0.1-0.1-0.5-0.2
Conditioned locomotion1.21.62.40.9-0.21.31.41.51.41.51.51.5-0.71.11.4
Patch foraging indifference point 0 sec0.50.91.8-0.80.3-1.0-1.1-1.2-0.9-1.2-1.3-0.90.3-0.7-0.7
Patch foraging indifference point AUC1.31.812.21.13.51.41.20.30.81.01.0-0.61.10.1-0.3
Delay disc. indifference point, 0s delay1.11.25.31.32.31.41.31.00.81.01.20.30.10.40.5
Delay disc. indifference point, 16s delay2.12.34.60.70.21.21.42.01.51.61.72.1-1.61.71.7
Delay disc. indifference point, 2s delay0.00.00.10.4-0.20.10.2-0.0-0.3-0.10.3-0.10.0-0.20.0
Delay disc. indifference point, 24s delay0.30.40.60.50.20.70.70.80.60.70.70.7-0.30.50.7
Delay disc. indifference point, 4s delay1.71.72.61.00.61.51.51.61.31.41.61.4-0.91.31.3
Delay disc. indifference point, 8s delay0.30.31.0-0.40.90.00.20.40.10.40.50.7-1.01.00.0
Indifference point function ln k1.22.08.6-1.8-2.9-1.8-1.6-0.8-1.1-1.3-1.30.3-1.30.1-0.3
Indifference point function log k1.22.08.6-1.8-2.9-1.8-1.6-0.8-1.1-1.3-1.30.3-1.30.1-0.3
Patch foraging total patch changes 0 sec0.61.02.1-1.00.1-1.2-1.3-1.3-1.0-1.3-1.5-0.90.1-0.7-0.7
Patch foraging total patch changes 12 sec0.30.41.30.61.20.40.3-0.40.00.10.0-0.91.1-0.6-0.3
Patch foraging total patch changes 18 sec0.10.20.6-0.10.8-0.3-0.3-0.7-0.2-0.3-0.4-0.80.1-0.3-0.4
Patch foraging total patch changes 24 sec1.11.94.9-0.21.0-0.8-0.9-1.8-1.2-1.3-1.1-2.21.7-1.4-1.5
Patch foraging total patch changes 6 sec0.60.95.30.02.3-0.1-0.2-0.7-0.5-0.5-0.5-1.21.0-0.6-1.1
Patch foraging time to switch 0 sec0.91.83.41.6-0.71.51.41.81.51.51.11.40.10.31.8
Patch foraging water rate 0 sec1.12.34.8-2.2-0.2-2.0-1.9-1.8-1.7-1.6-1.5-0.9-0.80.0-1.5
Patch foraging water rate 12 sec3.16.59.9-3.1-1.5-3.2-3.0-3.1-3.0-2.9-2.6-2.00.0-0.9-2.8
Patch foraging water rate 18 sec0.60.91.7-1.1-0.8-1.2-1.1-0.8-1.3-1.3-0.7-0.5-0.3-0.3-1.0
Patch foraging water rate 24 sec1.11.52.9-0.40.1-0.9-0.9-1.5-1.6-1.3-0.9-1.71.3-1.2-1.7
Patch foraging water rate 6 sec1.31.83.4-1.5-0.3-1.5-1.4-1.8-1.6-1.6-1.1-1.40.2-0.5-1.8
Seeking ratio, delayed vs. immediate footshock0.20.30.9-1.00.1-0.6-0.5-0.1-0.3-0.5-0.10.4-0.80.5-0.6
Distance traveled before self-admin0.00.00.1-0.1-0.0-0.3-0.3-0.3-0.1-0.2-0.4-0.20.0-0.2-0.0
Distance traveled after self-admin1.82.24.3-2.0-2.0-2.1-2.0-1.4-1.2-1.4-1.9-0.6-0.3-0.5-0.8
Extensor digitorum longus weight1.66.327.2-5.2-1.3-3.0-2.8-1.7-1.4-1.4-1.70.7-3.22.4-1.8
Bone: elastic displacement0.10.10.5-0.10.60.30.40.10.30.30.50.2-0.50.7-0.0
Bone: elastic work1.01.42.20.50.51.11.21.31.31.31.41.5-1.01.41.1
Bone: endosteal estimation0.61.24.9-2.2-0.2-1.6-1.5-0.6-0.7-0.6-1.20.4-1.20.7-0.7
Bone: endosteal perimeter0.71.55.3-2.30.0-1.1-1.00.3-0.0-0.0-0.41.6-2.21.8-0.0
Epididymis fat weight0.10.21.00.20.70.1-0.1-0.1-0.3-0.3-0.4-0.61.0-0.7-0.3
Delta time in closed arm before/after self-admin0.30.30.50.50.10.50.60.30.70.70.50.4-0.40.40.7
Delta time in open arm before/after self-admin1.01.03.00.3-1.0-0.3-0.5-0.9-0.9-0.9-0.7-1.31.7-1.5-0.7
Diff in mean of infusions in LGA sessions1.51.84.1-0.10.61.01.11.21.51.51.41.7-1.72.00.9
Delay discount exponential model param0.50.61.3-0.1-0.5-0.5-0.6-0.9-0.5-0.7-0.9-1.11.1-1.1-0.7
Extinction: sum of active levers before priming1.11.23.1-0.6-0.3-0.9-1.1-1.7-0.9-1.0-1.5-1.70.6-1.1-0.8
Active lever presses in extinction session 60.30.31.5-0.7-0.1-0.5-0.5-1.2-0.4-0.2-0.4-0.7-0.10.1-0.6
Bone: final force0.50.72.6-0.6-0.9-0.1-0.00.90.60.60.21.6-1.31.10.9
Bone: final moment0.71.13.5-0.4-1.20.10.21.20.80.80.51.9-1.51.21.3
Food consumed during 24 hour testing period1.42.03.9-1.7-0.6-2.0-1.8-1.5-1.7-1.6-1.6-0.9-0.3-0.5-1.3
Glucose1.21.93.6-1.2-0.5-1.5-1.4-1.9-1.7-1.6-1.2-1.60.3-0.8-1.7
Heart weight0.50.84.6-0.62.10.30.40.70.60.60.60.7-0.61.3-0.3
Delay discount hyperbolic model param0.70.81.4-0.3-0.4-0.7-0.8-1.0-0.7-0.9-1.1-1.21.2-1.2-0.9
Intermittent access intake day 1-15 change0.40.92.1-0.4-1.3-1.0-0.9-0.9-1.4-0.9-0.7-0.80.6-1.1-0.9
Intermittent access intake escalation0.30.62.1-0.5-1.4-0.9-0.8-0.7-1.2-0.6-0.5-0.40.4-0.7-0.7
Intermittent access intake escalation 20.40.41.4-0.9-1.2-0.9-0.7-0.4-0.5-0.5-0.40.2-0.70.1-0.2
Intermitt. access day 1 inactive lever presses0.10.41.10.8-1.10.40.60.90.20.20.60.8-0.20.10.6
Intermitt. access day 15 inactive lever presses0.10.20.9-0.6-0.9-0.4-0.3-0.3-0.5-0.1-0.10.3-0.40.4-0.2
Intermitt. access escalation Index0.40.62.0-0.41.40.30.20.50.60.30.20.8-1.41.10.5
Intermittent access day 1 total infusions0.20.31.11.1-0.80.40.30.00.20.20.2-0.30.8-0.90.6
Intermittent access day 15 total infusions0.20.30.80.9-0.90.30.30.2-0.20.30.4-0.00.8-0.70.4
Intermittent access terminal intake (last 3 days)0.30.41.20.8-1.10.50.60.60.40.60.80.60.0-0.10.9
Intermittent access total infusions0.30.41.50.5-1.2-0.3-0.3-0.4-0.4-0.4-0.2-0.50.9-1.00.1
Intermittent access day 1 locomotion0.50.72.61.6-0.60.90.80.40.20.60.6-0.11.2-0.90.7
Intermittent access day 15 total locomotion0.30.52.50.8-1.60.40.50.50.40.60.50.50.1-0.11.0
Intermittent access total locomotion0.20.21.3-0.0-1.1-0.3-0.3-0.4-0.4-0.3-0.2-0.20.4-0.4-0.0
Intermittent access standard deviation0.30.73.6-0.4-1.9-0.9-0.8-1.0-0.7-0.6-0.8-0.6-0.0-0.7-0.1
Left kidney weight0.83.611.2-3.3-1.4-2.7-2.4-1.6-1.8-2.0-1.7-0.1-1.40.7-1.6
Right kidney weight1.04.510.8-3.3-0.6-2.8-2.7-2.2-2.2-2.4-2.1-1.2-0.1-0.0-2.6
Cocaine induced anxiety0.81.11.40.60.91.01.01.11.21.21.01.1-1.21.11.2
Post-drug Anxiety0.70.72.41.51.51.00.80.20.30.50.4-0.61.0-0.80.2
Baseline Anxiety2.93.38.80.61.2-0.6-0.8-1.9-1.6-1.6-1.3-2.73.0-2.6-1.9
Tail length0.31.35.40.71.00.2-0.2-1.1-0.3-0.5-0.8-1.92.3-1.6-0.8
Length with tail0.00.20.5-0.70.2-0.3-0.5-0.7-0.1-0.3-0.5-0.60.60.1-0.4
Length without tail0.72.17.5-2.6-0.3-0.9-0.70.10.20.10.21.6-2.72.70.2
Times rat made contact with spout0.20.20.5-0.2-0.6-0.7-0.4-0.3-0.7-0.5-0.3-0.2-0.6-0.3-0.4
Lifetime Intake0.30.41.50.4-1.2-0.2-0.3-0.4-0.3-0.4-0.3-0.50.9-1.00.1
Liver weight, left1.83.07.4-2.70.0-2.3-2.0-2.0-2.0-1.8-1.4-1.0-0.70.3-2.2
Liver weight, right0.61.12.7-1.6-1.1-1.4-1.3-0.9-1.1-1.1-1.0-0.40.10.0-1.2
Locomotor activity1.21.97.5-2.7-0.7-1.7-1.6-1.0-0.8-0.9-1.00.4-1.91.3-0.4
Locomotor testing distance1.32.37.0-2.6-1.3-2.0-1.8-1.6-1.4-1.5-1.3-0.2-1.30.7-1.0
Locomotor testing rearing0.40.81.9-1.40.1-1.0-0.9-1.2-1.0-0.9-0.6-0.6-0.20.2-1.2
Locomotion in novel chamber0.20.31.20.3-1.10.10.30.30.40.20.70.5-0.80.40.6
Locomotion in novel chamber post-restriction0.61.01.91.00.71.21.21.01.31.41.20.70.20.70.9
Fecal boli incidents, locomotor time 10.60.91.50.81.11.11.01.21.21.00.80.8-0.40.61.0
Change in fecal boli incidents, locomotor task2.42.35.3-1.6-2.3-2.0-1.8-1.7-1.6-1.6-1.6-0.9-0.5-0.7-1.0
Time >=10cm from walls, locomotor time 10.50.61.6-0.3-0.80.10.30.70.20.70.71.3-1.21.10.4
Bouts of movement, locomotor time 10.20.20.8-0.40.8-0.2-0.20.10.3-0.0-0.30.2-0.90.40.0
Total resting periods, locomotor time 10.10.10.5-0.40.6-0.3-0.40.00.2-0.1-0.40.1-0.70.2-0.1
Rest time, locomotor task time 10.70.92.90.1-0.10.40.40.91.41.00.41.1-1.71.01.3
Distance moved, locomotor task time 10.40.62.70.50.50.20.0-0.8-0.7-0.4-0.2-1.11.6-1.0-0.6
Vertical activity count, locomotor time 10.10.31.10.61.00.70.6-0.0-0.10.30.5-0.20.6-0.00.1
Time >=10cm from walls, locomotor time 20.20.31.8-0.20.5-0.10.00.10.00.20.20.6-1.40.70.3
Bouts of movement, locomotor time 20.50.82.5-1.01.6-1.0-0.9-0.4-0.8-1.0-0.8-0.3-0.2-0.2-1.2
Total resting periods, locomotor time 20.61.02.1-1.21.4-1.2-1.2-0.6-0.9-1.2-1.1-0.6-0.1-0.4-1.4
Rest time, locomotor task time 20.10.10.40.20.10.00.10.40.60.3-0.20.2-0.50.10.6
Distance moved, locomotor task time 20.70.82.30.10.7-0.1-0.4-1.2-0.9-0.7-0.6-1.41.5-1.1-0.9
Vertical activity count, locomotor time 20.40.61.70.80.90.30.1-0.7-0.5-0.4-0.2-1.01.3-1.2-0.2
Light reinforcement 10.61.45.7-1.91.2-0.7-0.5-0.60.00.0-0.20.5-2.42.0-0.2
Light reinforcement 20.20.31.30.2-1.0-0.00.1-0.20.40.20.10.0-1.20.30.9
Bone: marrow area0.61.35.0-2.2-0.3-1.6-1.5-0.6-0.7-0.6-1.10.4-1.30.8-0.6
Bone: maximum diameter1.12.05.8-2.4-1.8-1.8-1.6-0.5-0.7-0.6-1.11.0-2.11.10.1
Bone: maximum force0.50.93.0-0.6-0.80.00.01.00.80.70.31.7-1.31.21.0
Bone: maximum moment0.71.23.9-0.4-1.20.20.21.20.90.90.52.0-1.51.31.3
Mean time between licks in bursts0.10.30.60.80.60.70.70.30.40.40.70.00.8-0.00.2
Mean num. licks in bursts0.71.14.1-1.5-1.6-1.0-0.7-0.0-0.3-0.2-0.30.9-2.01.20.2
Cd content in liver1.71.85.51.52.41.71.61.21.31.21.50.7-0.10.50.9
Co content in liver2.83.34.91.41.21.92.02.12.22.02.01.7-1.21.71.9
Cu content in liver0.60.71.20.2-0.60.70.71.00.90.70.81.1-0.91.00.8
Fe content in liver0.81.01.7-0.8-0.1-1.2-1.2-1.0-1.2-1.2-1.3-0.9-0.1-0.9-1.0
K content in liver0.10.10.7-0.8-0.3-0.3-0.4-0.4-0.1-0.4-0.3-0.2-0.10.4-0.3
Mg content in liver0.10.10.7-0.80.3-0.2-0.3-0.3-0.1-0.3-0.1-0.0-0.10.6-0.4
Mn content in liver1.01.13.6-0.4-1.9-0.00.10.70.70.50.41.4-1.71.21.3
Na content in liver1.71.85.5-2.30.3-1.7-1.8-1.4-1.1-1.3-1.6-0.6-0.60.3-1.3
Rb content in liver0.91.01.6-1.1-0.7-1.1-1.2-1.2-1.1-1.1-1.3-0.90.2-0.6-0.9
Se content in liver0.60.71.5-0.1-0.3-0.6-0.8-1.1-0.8-1.1-1.0-1.20.8-1.2-0.5
Sr content in liver0.60.52.60.81.60.90.60.50.60.60.4-0.10.3-0.10.4
Zn content in liver1.01.12.50.40.51.11.21.11.10.81.61.1-0.91.50.7
Bone: minimum diameter1.62.87.50.0-1.00.70.92.11.51.51.22.7-2.41.92.0
Time in familiar zone, hab. session 10.60.61.30.10.50.50.60.80.90.90.71.0-0.81.10.8
Time in novel zone, hab. session 10.30.31.30.2-1.1-0.2-0.3-0.5-0.6-0.5-0.5-0.60.4-0.9-0.2
Total zone transitions, hab. session 10.71.02.60.10.3-0.6-0.6-1.3-1.0-1.1-1.0-1.60.9-1.4-1.0
Total locomotion distance, hab. session 10.70.92.4-0.0-0.0-0.6-0.6-1.2-1.1-1.1-0.7-1.61.0-1.1-1.2
Locomotion velocity, hab. session 10.71.02.1-0.3-0.2-0.8-0.8-1.2-1.2-1.2-0.8-1.40.9-1.0-1.3
Time in familiar zone, hab. session 20.40.41.10.1-0.1-0.3-0.3-0.8-0.5-0.7-0.4-1.11.0-0.8-0.6
Time in novel zone, hab. session 20.50.51.5-0.3-1.2-0.10.00.60.20.40.31.1-1.20.70.7
Total zone transitions, hab. session 20.30.32.60.11.60.50.50.00.20.10.5-0.3-0.00.4-0.6
Total locomotion distance, hab. session 20.30.42.50.01.60.50.60.50.30.30.90.2-0.10.7-0.6
Locomotion velocity, hab. session 20.30.41.60.21.30.60.70.70.50.51.00.4-0.20.8-0.3
Novel to familiar place preference ratio0.60.72.5-0.7-0.10.20.10.80.70.60.31.3-1.61.20.6
Novelty place preference0.80.83.1-0.7-0.50.10.10.80.70.60.41.4-1.81.30.7
Time in novel zone, NPP test0.70.83.3-1.0-0.8-0.2-0.20.50.50.40.11.3-1.81.20.6
Total zone transitions, NPP test0.30.42.3-0.41.5-0.4-0.3-0.5-0.5-0.6-0.1-0.5-0.00.0-1.1
Total locomotion distance, NPP test0.50.72.3-0.60.8-0.7-0.7-0.8-1.0-1.0-0.6-0.90.6-0.5-1.5
Locomotion velocity, NPP test0.60.82.1-0.21.2-0.5-0.5-0.8-0.9-0.9-0.5-1.21.1-0.8-1.4
Intraocular pressure0.10.10.60.10.50.20.10.00.20.40.0-0.20.8-0.1-0.1
Delta distance traveled before/after self-admin2.02.15.7-2.0-2.4-1.9-1.7-1.2-1.4-1.4-1.4-0.5-0.4-0.2-1.1
Delta ambulatory time before/after self-admin1.41.89.8-1.6-3.1-1.6-1.4-0.9-1.0-1.1-1.0-0.2-0.4-0.0-0.6
Parametrial fat weight0.40.93.11.61.20.80.6-0.20.3-0.00.2-1.31.8-1.20.0
Pavlov. Cond. lever latency1.01.37.8-0.5-2.8-1.1-1.0-0.8-1.2-1.1-0.8-0.50.1-0.8-0.4
Pavlov. Cond. magazine entry latency9.912.718.72.84.34.04.04.24.04.03.83.3-1.02.83.0
Pavlov. Cond. change in total contacts3.73.95.51.32.32.22.12.32.32.32.11.9-0.81.81.6
Pavlov. Cond. index score5.16.517.52.24.23.02.82.72.82.82.51.8-0.11.61.8
Pavlov. Cond. latency score3.74.716.21.84.02.62.42.12.42.32.01.3-0.01.31.4
Pavlov. Cond. lever contacts2.22.69.11.03.01.71.61.61.91.81.41.2-0.41.31.0
Pavlov. Cond. magazine entry number8.710.915.8-2.8-4.0-3.8-3.7-4.0-3.7-3.7-3.6-3.00.8-2.4-2.8
Pavlov. Cond. intertrial magazine entries2.73.26.1-0.6-1.5-1.3-1.5-2.2-1.8-1.8-1.7-2.51.8-2.0-2.1
Pavlov. Cond. lever-magazine prob. diff.5.26.418.02.14.22.92.82.72.82.72.51.8-0.21.71.8
Pavlov. Cond. response bias8.09.814.52.33.73.53.43.83.63.63.33.1-1.12.62.6
Pavlov. Cond. lever latency1.11.52.7-1.0-1.1-1.3-1.3-1.7-1.5-1.3-1.3-1.30.3-1.0-1.1
Pavlov. Cond. magazine entry latency0.81.03.82.00.51.31.30.70.80.81.1-0.20.9-0.40.8
Pavlov. Cond. change in total contacts0.50.71.31.20.71.21.01.01.10.80.90.40.30.20.8
Pavlov. Cond. index score0.71.01.91.40.81.31.21.11.21.01.10.40.50.20.9
Pavlov. Cond. latency score0.40.51.11.00.50.90.90.80.90.70.80.20.40.20.7
Pavlov. Cond. lever contacts0.81.12.00.91.21.11.11.41.31.21.11.0-0.10.81.0
Pavlov. Cond. magazine entry number0.81.03.7-1.9-0.4-1.3-1.2-0.9-0.8-0.7-0.90.1-1.00.6-0.8
Pavlov. Cond. intertrial magazine entries0.71.01.7-1.1-0.3-1.1-1.1-1.2-1.1-1.0-1.2-1.00.7-0.7-1.3
Pavlov. Cond. lever-magazine prob. diff.0.81.12.21.51.01.41.31.11.21.01.10.30.60.10.9
Pavlov. Cond. response bias2.12.94.41.91.72.12.02.11.91.81.91.20.20.81.5
Time in closed arm before self-admin0.70.91.80.70.10.91.01.30.91.11.21.2-0.50.80.8
Time in closed arm after self-admin0.20.20.40.60.10.60.60.50.50.60.60.4-0.20.30.5
Time in open arm before self-admin0.30.41.5-1.20.2-0.7-0.6-0.40.0-0.2-0.40.3-0.90.8-0.1
Time in open arm after self-admin0.30.30.9-0.8-0.9-0.8-0.8-0.5-0.5-0.6-0.6-0.1-0.1-0.0-0.3
Bone: periosteal estimation0.71.44.0-2.0-1.5-1.5-1.3-0.2-0.5-0.4-0.91.0-1.70.90.1
Bone: periosteal perimeter0.71.33.8-2.0-1.5-1.3-1.2-0.1-0.3-0.4-0.81.1-1.71.00.2
Bone: post-yield work0.00.10.2-0.2-0.00.1-0.00.40.30.3-0.10.40.30.2-0.0
Progressive ratio test 1 active lever presses0.30.31.00.5-0.5-0.1-0.2-0.5-0.5-0.3-0.2-0.71.0-1.0-0.2
Progressive ratio test 1 breakpoint0.20.31.00.5-0.4-0.1-0.2-0.5-0.5-0.3-0.1-0.71.0-1.0-0.1
Progressive ratio test 1 inactive lever presses1.31.96.21.2-1.6-0.3-0.4-0.9-1.3-1.2-0.7-1.52.2-2.5-0.6
Progressive ratio test 2 active lever presses0.30.41.8-0.6-1.3-0.8-0.7-0.5-0.7-0.5-0.4-0.1-0.2-0.2-0.3
Progressive ratio test 2 breakpoint0.30.41.7-0.6-1.3-0.8-0.7-0.5-0.7-0.5-0.4-0.1-0.1-0.2-0.3
Progressive ratio test 2 inactive lever presses0.20.44.00.2-2.0-0.2-0.1-0.0-0.3-0.3-0.00.3-0.1-0.30.5
Incentive Sensitization - Responses0.60.82.8-1.0-1.3-0.5-0.20.5-0.2-0.00.21.4-1.71.20.2
Incentive Sensitization - Breakpoint0.60.72.5-0.9-1.2-0.5-0.10.6-0.10.00.21.4-1.61.20.2
Sum of active levers in priming session hrs 5-60.50.51.0-0.5-0.7-0.7-0.8-1.0-0.5-0.6-1.0-0.80.4-0.6-0.4
Progressive ratio2.53.95.51.51.82.22.22.12.32.32.21.7-1.11.71.9
Food seeking constrained by brief footshock2.02.54.5-1.00.3-1.5-1.6-2.1-1.9-1.7-1.8-2.00.7-1.4-1.6
Seeking ratio, punishment vs. effort5.37.611.1-2.9-1.2-3.3-3.3-3.2-3.3-3.2-3.1-2.41.0-1.8-3.0
Retroperitoneal fat weight0.41.74.20.31.2-0.6-0.7-1.4-1.1-1.3-1.1-2.01.8-1.8-1.2
Reaction time number correct0.40.71.6-1.3-0.1-1.0-0.9-0.9-1.2-0.9-0.7-0.4-0.0-0.1-1.1
Reaction time mean minus median0.20.51.40.3-0.1-0.3-0.5-0.9-0.6-0.7-0.8-1.20.7-1.2-0.4
Reaction time mean minus median AUC0.41.13.30.6-0.7-0.4-0.6-1.3-0.7-0.9-1.2-1.71.1-1.8-0.4
Reaction time num false alarms0.30.41.50.4-0.1-0.1-0.30.0-0.7-0.6-0.4-0.41.2-1.2-0.4
Reaction time num false alarms AUC0.71.02.5-0.1-0.4-0.8-1.0-0.6-1.3-1.2-1.1-0.81.4-1.6-0.9
Reaction time trials correct on left0.40.71.6-1.3-0.1-1.0-0.9-0.9-1.2-0.9-0.7-0.4-0.0-0.1-1.1
Reaction time trials on left0.40.81.6-1.3-0.1-1.0-1.0-0.9-1.2-0.9-0.8-0.50.0-0.1-1.1
Reaction time mean0.40.63.11.80.30.90.80.20.40.40.4-0.60.8-1.10.6
Reaction time mean AUC0.40.62.71.60.60.80.60.00.30.30.1-0.80.8-1.20.6
Median of all reaction times0.81.25.02.20.51.31.30.80.80.90.9-0.20.7-0.81.1
Reaction time omissions0.60.81.8-0.30.8-0.5-0.8-1.3-0.7-0.8-1.0-1.30.8-1.1-0.9
Reaction time false alarm rate0.30.41.80.7-0.3-0.1-0.2-0.0-0.4-0.5-0.5-0.51.3-1.3-0.2
Reaction time premature initiation rate0.40.61.5-0.90.2-0.7-0.7-1.2-0.8-0.7-0.7-1.00.1-0.2-1.1
Reaction time premature initiations0.50.91.9-1.4-0.1-1.0-1.0-1.3-1.1-0.9-0.9-0.9-0.2-0.1-1.3
Std. dev. reaction times0.30.62.11.10.20.30.1-0.5-0.2-0.2-0.4-1.11.2-1.40.1
Reaction time trials completed0.40.81.6-1.3-0.1-1.0-1.0-0.9-1.2-0.9-0.8-0.50.0-0.1-1.1
Reaction time trials AUC0.30.61.3-1.1-0.1-0.9-0.9-0.9-1.1-0.8-0.7-0.50.1-0.1-1.1
Run reversals in cocaine runway, females0.50.50.8-0.5-0.2-0.8-0.9-0.6-0.8-0.8-0.8-0.60.6-0.8-0.8
Run reversals in cocaine runway, males0.60.61.1-0.30.5-0.4-0.6-0.8-0.9-0.6-0.8-1.10.8-0.9-0.9
Latency to leave start box in cocaine runway0.70.82.4-1.50.4-1.2-1.2-0.8-0.7-0.9-1.1-0.3-0.80.2-0.8
Latency to leave start box in cocaine runway, F1.11.32.2-1.00.4-1.1-1.3-1.4-1.1-1.2-1.5-1.30.7-0.9-1.3
Latency to leave start box in cocaine runway, M1.51.46.0-2.00.0-1.1-0.90.3-0.1-0.4-0.31.2-2.41.6-0.2
Std. dev. time between licks in bursts0.60.81.80.21.31.00.91.01.01.01.21.0-0.01.00.2
Total sessions with >9 infusions1.51.84.50.5-1.6-0.7-0.7-1.4-1.3-1.0-1.0-1.72.1-2.1-0.8
Short access day 1 total inactive lever presses0.81.07.7-0.1-2.8-0.8-0.7-0.5-0.9-0.7-0.7-0.20.6-1.00.1
Short access day 10 total inactive lever presses0.10.20.50.3-0.7-0.1-0.1-0.0-0.6-0.6-0.3-0.10.5-0.7-0.1
Short access day 1 total infusions0.50.62.8-0.0-1.7-0.6-0.7-0.7-0.6-0.5-0.8-0.71.0-1.0-0.1
Short access day 10 total infusions0.40.51.91.4-0.80.50.50.20.3-0.00.2-0.41.3-1.10.6
Short access total infusions0.60.83.00.9-1.20.0-0.1-0.6-0.3-0.4-0.4-1.01.7-1.6-0.0
Short access day 1 locomotion0.00.10.20.2-0.40.20.2-0.10.20.30.10.00.20.10.4
Short access day 10 total locomotion0.51.03.8-0.1-1.9-0.8-0.8-1.0-0.9-1.0-0.9-1.00.9-1.1-0.4
Short access total locomotion0.40.41.90.6-1.4-0.0-0.1-0.5-0.4-0.3-0.3-0.61.0-0.90.2
One hour access (0.3 mA shock)0.60.73.1-1.0-1.8-0.8-0.6-0.20.2-0.3-0.30.6-1.50.70.4
Compulsive drug intake1.21.43.9-1.3-2.0-1.5-1.3-1.3-1.0-1.1-1.4-0.6-0.6-0.3-0.8
One hour access (shock baseline)0.20.30.80.40.10.50.50.60.90.40.70.7-0.40.40.9
Social response proportion1.31.53.2-0.1-0.40.60.71.21.31.31.01.8-1.61.61.5
Social responses0.00.10.3-0.10.50.10.10.10.10.20.10.3-0.40.30.2
Social time0.60.91.6-0.7-0.9-1.1-1.1-1.3-0.9-1.0-1.2-0.90.2-0.8-0.5
Soleus weight3.610.542.8-6.5-1.2-4.2-3.9-2.5-2.2-2.4-2.60.3-3.42.5-2.8
Bone: stiffness0.91.52.8-1.4-0.9-1.6-1.7-1.2-1.3-1.3-1.7-0.60.5-0.9-0.9
Tibialis anterior weight4.314.548.5-7.0-2.4-5.1-4.8-3.6-3.4-3.3-3.5-0.6-2.91.5-3.4
Time to tail flick, vehicle, before self-admin1.11.17.91.12.81.21.00.60.70.70.6-0.20.6-0.1-0.1
Time to tail flick, vehicle, after self-admin0.10.10.80.0-0.9-0.10.00.30.10.20.20.5-0.20.10.3
Time to tail flick, test, before self-admin4.54.67.01.91.52.52.52.62.42.42.52.2-0.71.62.1
Time to tail flick, test, after self-admin0.50.52.01.40.20.80.60.20.40.20.2-0.61.0-0.90.6
Delta time to tail flick, vehicle, before/after SA0.40.43.3-0.2-1.8-0.6-0.4-0.2-0.4-0.3-0.20.1-0.2-0.20.3
Delta time to tail flick, test, before/after SA1.61.62.8-0.9-1.7-1.5-1.4-1.6-1.3-1.5-1.5-1.20.0-1.0-0.7
Tibia length0.82.14.8-0.0-0.10.60.91.71.51.61.22.2-1.72.01.8
Ambulatory time before self-admin0.10.10.40.40.40.0-0.1-0.10.00.0-0.3-0.20.5-0.60.1
Ambulatory time after self-admin1.51.85.8-1.5-2.4-1.8-1.7-1.2-1.1-1.2-1.5-0.4-0.1-0.6-0.7
Bone: tissue strength0.30.30.90.9-0.30.60.60.60.30.50.40.3-0.0-0.20.7
Total heroin consumption0.50.61.8-0.90.4-0.7-0.8-1.4-0.3-0.5-0.9-0.90.3-0.3-0.9
Bone: trabecular number0.61.02.21.51.01.41.31.10.90.91.10.30.4-0.20.6
Bone: trabecular spacing0.10.10.2-0.30.1-0.5-0.4-0.4-0.2-0.2-0.5-0.30.2-0.1-0.2
Bone: trabecular thickness0.30.43.4-0.1-1.8-0.2-0.10.0-0.2-0.20.10.4-1.00.20.5
Bone: trabecular tissue density2.84.211.2-3.3-3.3-2.7-2.5-1.8-1.4-1.6-1.90.2-1.60.8-0.6
Water consumed over 24 hours0.10.10.30.3-0.10.10.30.40.20.30.30.3-0.50.20.3
Number of responses in last shaping day0.00.00.2-0.1-0.3-0.1-0.00.1-0.5-0.10.20.20.10.0-0.1