Rfx7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IL	mRNA stability	Rfx7	0.19	0.11	4.7e-03	0.08	0.1	0.07	0.06	6.0e-03	1.8e-03	7.2e-03	1.8e-02
2	Liver	mRNA stability	Rfx7	0.1	0.1	1.6e-04	0.03	0.01	0.03	0.02	4.6e-04	7.8e-03	9.9e-05	1.6e-03
3	OFC	mRNA stability	Rfx7	0.38	0.16	2.2e-05	0.19	0.21	0.2	0.19	3.4e-05	1.2e-05	2.1e-05	2.4e-05
4	PL	mRNA stability	Rfx7	0.04	0.03	2.6e-04	0.04	0.04	0.04	0.04	9.1e-05	3.7e-05	5.3e-05	5.8e-05
5	PL	gene expression	Rfx7	0.03	0.02	1.4e-03	0.03	0.03	0.03	0.03	3.1e-04	5.6e-04	5.9e-04	1.9e-04
6	BLA	gene expression	Rfx7	0.12	0.07	1.7e-05	0.1	0.07	0.06	0.08	8.1e-06	2.1e-04	2.6e-04	5.0e-05
7	LHb	mRNA stability	Rfx7	0.19	0.13	9.0e-03	0.09	0.05	0.04	0.07	4.7e-03	2.2e-02	5.0e-02	9.4e-03
8	NAcc	gene expression	Rfx7	0.03	0.02	5.4e-05	0.02	0.02	0.01	0.01	2.9e-04	7.0e-04	2.8e-03	1.9e-03
9	Adipose	gene expression	Rfx7	0.06	0.06	8.5e-04	0.03	0.01	0.03	0.02	8.2e-04	4.9e-02	6.7e-04	4.4e-03
10	Eye	isoform ratio	NM_001127490.2	0.28	0.16	8.5e-03	0.11	0.11	0.1	0.16	8.7e-03	8.9e-03	1.1e-02	2.0e-03
11	Eye	isoform ratio	XM_006243326.5	0.29	0.14	1.5e-03	0.06	0.18	0.16	0.1	4.7e-02	9.9e-04	2.2e-03	1.2e-02
12	Adipose	isoform ratio	XM_039081516.2	0.1	0.07	2.9e-04	0.01	0.02	0.02	0.01	2.0e-02	1.2e-03	4.2e-03	2.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12
Bone: apparent density	0.2	0.4	0.9	0.8	0.1	0.9	0.8	0.8	-0.6	-0.7	-0.9	-0.5	-0.1	0.2	0.5
Area under the delay curve	0.6	0.9	1.7	0.2	-0.6	0.7	0.8	1.1	-0.7	-0.9	-1.1	-1.3	-1.3	1.3	0.9
BMI with tail	1.7	5.9	22.8	-4.8	0.1	-2.7	-2.3	-1.0	1.1	1.1	1.0	-1.5	-4.3	3.1	-1.1
BMI without tail	0.4	2.0	7.5	-2.7	-0.4	-1.8	-1.7	-1.2	1.0	1.0	1.3	0.2	-1.5	1.0	-1.2
Body weight	1.0	4.2	15.0	-3.8	-0.1	-1.5	-1.2	-0.1	-0.3	-0.1	-0.0	-1.9	-3.9	3.6	-0.0
Weight adjusted by age	1.2	3.4	8.8	-3.0	0.9	-2.5	-2.4	-1.5	1.9	2.2	2.0	0.5	-0.9	0.2	-1.8
Bone surface	0.0	0.0	0.1	-0.3	0.3	-0.2	-0.2	-0.1	0.2	0.1	0.1	-0.1	0.1	0.0	-0.3
Bone volume	0.1	0.1	0.3	-0.2	0.5	0.1	0.1	0.4	-0.1	-0.2	-0.3	-0.6	-0.4	0.4	0.1
Breakpoint value in progressive ratio session	0.1	0.1	0.5	-0.2	-0.6	0.0	-0.0	-0.7	-0.3	-0.2	0.2	0.4	-0.2	0.2	-0.0
Number of licking bursts	0.3	0.8	2.8	1.3	-0.9	0.3	0.2	-0.4	0.3	0.3	0.2	1.2	1.7	-1.5	-0.6
Context. condit. distance diff. score	1.0	1.2	2.7	0.7	0.5	0.9	1.0	1.6	-1.1	-1.2	-1.2	-1.6	-0.6	0.8	1.1
Locomotion velocity, session 1	2.9	3.2	5.6	-1.9	0.0	-2.2	-2.2	-2.4	1.9	2.0	2.1	1.8	0.0	-1.0	-1.9
Locomotion distance, session 1	0.3	0.4	1.1	0.2	-0.1	-0.5	-0.4	-0.8	0.7	0.8	0.6	1.0	0.3	-1.0	-0.6
Locomotion velocity, session 2	0.2	0.3	1.4	-0.4	-1.2	-0.2	-0.5	-0.5	0.2	0.3	0.8	0.4	-0.4	-0.3	-0.1
Locomotion distance, session 2	0.3	0.5	0.8	-0.5	-0.3	-0.6	-0.7	-0.9	0.7	0.9	0.9	0.9	-0.1	-0.6	-0.7
Locomotion velocity, session 3	2.1	2.4	5.2	-0.2	0.5	-1.0	-1.3	-1.9	1.6	1.7	1.9	2.3	1.6	-2.1	-1.2
Locomotion distance, session 3	0.6	0.7	2.3	1.5	-0.1	0.7	0.6	-0.1	0.0	0.0	-0.1	1.0	1.4	-1.3	-0.1
Stereotopy head waving bouts, day 3	0.5	0.6	1.1	-1.0	0.8	-1.0	-0.9	-0.8	0.9	0.9	0.7	0.3	-0.5	-0.1	-0.5
Stereotopy head waving duration, day 3	0.8	0.9	2.0	-1.4	1.1	-1.4	-1.3	-0.9	1.0	1.1	0.9	0.2	-0.6	-0.0	-0.5
Locomotion velocity, session 7	0.3	0.4	1.2	1.1	0.4	0.6	0.5	0.7	-0.5	-0.5	-0.2	-0.2	0.6	-0.5	0.7
Locomotion distance, session 7	0.4	0.5	2.1	1.1	0.1	0.4	0.2	0.1	0.1	-0.0	0.3	0.6	1.5	-1.3	-0.1
Stereotopy head waving bouts, day 7	1.0	1.2	1.9	-1.2	0.1	-1.3	-1.3	-1.4	1.3	1.3	1.1	1.1	0.2	-0.4	-1.1
Stereotopy head waving duration, day 7	1.6	2.0	3.2	-1.3	0.4	-1.5	-1.6	-1.8	1.6	1.7	1.6	1.6	0.7	-1.0	-1.4
Locomotion velocity, session 8	0.6	0.7	1.5	-0.7	-0.2	-0.6	-0.9	-1.1	0.8	0.8	1.2	1.0	0.6	-0.9	-0.7
Locomotion distance, session 8	0.2	0.2	0.7	0.7	-0.8	0.6	0.4	0.6	-0.2	-0.3	-0.2	-0.1	0.7	-0.5	0.0
Degree of sensitization distance	0.0	0.0	0.1	0.2	0.2	0.0	-0.0	0.2	-0.1	-0.1	0.2	-0.2	0.3	-0.3	0.2
Degree of sensitization stereotypy	0.9	1.0	1.5	-1.1	0.2	-1.1	-1.1	-1.2	1.2	1.2	1.0	1.0	0.2	-0.4	-1.1
Conditioned locomotion	2.1	2.4	4.6	0.2	-0.2	1.0	1.1	1.8	-1.6	-1.6	-1.4	-2.1	-2.1	2.0	1.8
Cocaine response after cond. corrected	1.6	2.4	5.9	-2.4	1.9	-2.1	-2.0	-1.3	1.4	1.5	1.6	0.1	-1.3	0.2	-0.8
Cocaine response after cond. not corrected	1.1	1.6	4.1	-2.0	1.5	-1.8	-1.6	-1.0	1.1	1.2	1.3	-0.1	-1.2	0.3	-0.7
Cocaine response before conditioning	0.9	1.1	2.8	1.1	-1.7	1.1	1.2	1.1	-1.0	-1.1	-1.2	-0.6	0.2	0.5	0.6
Saline control response	0.9	1.2	2.1	-0.5	0.2	-1.1	-1.2	-1.3	1.4	1.4	1.2	1.3	0.8	-1.3	-0.8
Bone: connectivity density	0.4	0.7	1.7	1.3	-0.8	0.8	0.5	-0.1	0.2	0.1	-0.2	1.1	1.3	-1.3	-0.2
Bone: cortical apparent density	0.1	0.1	0.8	0.9	0.3	0.3	0.3	0.2	-0.1	-0.0	-0.1	0.1	0.4	-0.6	0.2
Bone: cortical area	0.9	1.4	8.4	-0.6	2.9	-0.5	-0.3	0.6	-0.3	-0.3	-0.0	-1.5	-1.6	0.9	1.3
Bone: cortical porosity	1.1	1.2	2.1	1.2	-0.6	1.2	1.2	1.4	-1.3	-1.3	-1.0	-1.1	-0.4	0.5	1.4
Bone: cortical porosity	2.6	2.8	4.4	1.6	-0.8	1.9	1.8	2.1	-2.1	-2.0	-1.7	-1.7	-0.5	1.0	2.0
Bone: cortical thickness	0.8	1.4	7.9	0.8	2.8	0.4	0.7	1.0	-0.7	-0.7	-0.8	-1.2	-0.8	0.4	1.6
Bone: cortical thickness	0.5	0.6	3.4	0.5	1.9	0.3	0.3	0.6	-0.6	-0.5	-0.2	-0.9	-0.4	0.1	1.2
Bone: cortical tissue density	0.1	0.2	0.8	0.9	0.0	0.3	0.3	0.1	-0.0	-0.0	-0.1	0.2	0.5	-0.7	0.1
Condit. Reinf. active minus inactive responses	2.2	2.5	5.0	1.2	-2.2	1.8	1.8	1.8	-1.9	-1.9	-1.7	-1.2	-0.1	1.3	0.8
Condit. Reinf. active-inactive response ratio	2.6	2.8	5.0	1.1	-0.8	1.6	1.8	2.2	-2.0	-1.9	-2.0	-2.1	-0.6	1.6	1.5
Condit. Reinf. active responses	0.6	0.8	4.6	0.6	-2.2	1.1	0.9	0.5	-0.9	-0.8	-0.6	0.1	0.7	0.3	-0.2
Condit. Reinf. inactive responses	1.8	2.3	5.9	-0.3	-1.0	-0.6	-1.0	-1.8	1.4	1.3	1.5	2.4	1.7	-1.8	-1.9
Incentive salience index mean	2.4	3.1	4.7	1.0	-2.2	1.9	1.8	2.1	-2.2	-2.1	-1.8	-1.7	-0.5	1.7	1.1
Condit. Reinf. lever presses	1.5	2.3	3.8	0.8	-1.6	1.6	1.5	1.9	-1.9	-1.9	-1.4	-1.6	-0.6	1.4	1.2
Condit. Reinf. active minus inactive responses	0.2	0.4	2.1	-1.4	-0.2	-0.5	-0.6	-0.1	0.0	0.4	0.1	-0.5	-0.3	0.8	-0.7
Condit. Reinf. active-inactive response ratio	0.3	0.5	1.6	-1.3	1.0	-0.6	-0.5	0.2	-0.1	0.2	0.0	-1.0	-0.7	1.0	-0.0
Condit. Reinf. active responses	0.4	0.6	1.6	-0.9	-1.2	0.1	0.1	0.7	-0.6	-0.3	-0.6	-1.1	-0.6	1.3	-0.3
Condit. Reinf. inactive responses	0.7	1.1	5.9	0.8	-2.4	1.1	1.1	1.0	-0.8	-0.9	-1.1	-0.3	0.1	0.4	-0.1
Condit. Reinf. lever presses	0.6	0.9	2.0	0.7	0.5	0.8	0.9	1.4	-1.2	-0.9	-1.0	-1.3	-0.1	0.6	1.1
Condit. Reinf. lever reinforcers received	0.5	0.7	1.9	-0.7	-0.9	0.3	0.3	0.9	-0.8	-0.5	-0.8	-1.2	-0.8	1.4	0.1
Conditioned reinforcement - actives	0.0	0.1	0.6	-0.2	0.8	-0.3	-0.3	-0.3	0.2	0.2	0.2	0.1	0.1	-0.2	-0.0
Conditioned reinforcement - inactives	0.2	0.5	3.1	-0.3	1.8	-0.7	-0.6	-0.4	1.0	0.5	0.5	0.1	-0.1	-0.5	-0.2
Conditioned locomotion	1.1	1.6	2.4	0.9	0.2	1.3	1.4	1.5	-1.4	-1.5	-1.5	-1.5	-0.7	1.1	1.4
Patch foraging indifference point 0 sec	0.3	0.9	1.8	-0.8	-0.3	-1.0	-1.1	-1.2	0.9	1.2	1.3	0.9	0.3	-0.7	-0.7
Patch foraging indifference point AUC	0.8	1.8	12.2	1.1	-3.5	1.4	1.2	0.3	-0.8	-1.0	-1.0	0.6	1.1	0.1	-0.3
Delay disc. indifference point, 0s delay	1.1	1.2	5.3	1.3	-2.3	1.4	1.3	1.0	-0.8	-1.0	-1.2	-0.3	0.1	0.4	0.5
Delay disc. indifference point, 16s delay	1.6	2.3	4.6	0.7	-0.1	1.2	1.4	2.0	-1.5	-1.6	-1.7	-2.1	-1.6	1.7	1.7
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	0.4	0.2	0.1	0.2	-0.0	0.3	0.1	-0.3	0.1	0.0	-0.2	0.0
Delay disc. indifference point, 24s delay	0.2	0.4	0.6	0.5	-0.1	0.7	0.7	0.8	-0.6	-0.7	-0.7	-0.7	-0.3	0.5	0.7
Delay disc. indifference point, 4s delay	1.6	1.7	2.6	1.0	-0.6	1.5	1.5	1.6	-1.3	-1.4	-1.6	-1.4	-0.9	1.3	1.3
Delay disc. indifference point, 8s delay	0.2	0.3	1.0	-0.4	-0.9	0.0	0.2	0.4	-0.1	-0.4	-0.5	-0.7	-1.0	1.0	0.0
Indifference point function ln k	0.7	2.0	8.6	-1.8	2.9	-1.8	-1.6	-0.8	1.1	1.3	1.3	-0.3	-1.3	0.1	-0.3
Indifference point function log k	0.7	2.0	8.6	-1.8	2.9	-1.8	-1.6	-0.8	1.1	1.3	1.3	-0.3	-1.3	0.1	-0.3
Patch foraging total patch changes 0 sec	0.4	1.0	2.1	-1.0	-0.1	-1.2	-1.3	-1.3	1.0	1.3	1.5	0.9	0.1	-0.7	-0.7
Patch foraging total patch changes 12 sec	0.3	0.4	1.3	0.6	-1.2	0.4	0.3	-0.4	-0.0	-0.1	-0.0	0.9	1.1	-0.6	-0.3
Patch foraging total patch changes 18 sec	0.1	0.2	0.6	-0.1	-0.8	-0.3	-0.3	-0.7	0.2	0.3	0.4	0.8	0.1	-0.3	-0.4
Patch foraging total patch changes 24 sec	0.5	1.9	4.9	-0.2	-1.0	-0.8	-0.9	-1.8	1.2	1.3	1.1	2.2	1.7	-1.4	-1.5
Patch foraging total patch changes 6 sec	0.5	0.9	5.3	0.0	-2.3	-0.1	-0.2	-0.7	0.5	0.5	0.5	1.2	1.0	-0.6	-1.1
Patch foraging time to switch 0 sec	0.5	1.8	3.4	1.6	0.7	1.5	1.4	1.8	-1.5	-1.5	-1.1	-1.4	0.1	0.3	1.8
Patch foraging water rate 0 sec	0.6	2.3	4.8	-2.2	0.2	-2.0	-1.9	-1.8	1.7	1.6	1.5	0.9	-0.8	0.0	-1.5
Patch foraging water rate 12 sec	1.6	6.5	9.9	-3.1	1.4	-3.2	-3.0	-3.1	3.0	2.9	2.6	2.0	0.0	-0.9	-2.8
Patch foraging water rate 18 sec	0.4	0.9	1.7	-1.1	0.8	-1.2	-1.1	-0.8	1.3	1.3	0.7	0.5	-0.3	-0.3	-1.0
Patch foraging water rate 24 sec	1.1	1.5	2.9	-0.4	-0.1	-0.9	-0.9	-1.5	1.6	1.3	0.9	1.7	1.3	-1.2	-1.7
Patch foraging water rate 6 sec	1.2	1.8	3.4	-1.5	0.3	-1.5	-1.4	-1.8	1.6	1.6	1.1	1.4	0.2	-0.5	-1.8
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.9	-1.0	-0.1	-0.6	-0.5	-0.1	0.3	0.5	0.1	-0.4	-0.8	0.5	-0.6
Distance traveled before self-admin	0.0	0.0	0.1	-0.1	0.0	-0.3	-0.3	-0.3	0.1	0.2	0.4	0.2	0.0	-0.2	-0.0
Distance traveled after self-admin	1.3	2.2	4.3	-2.0	2.0	-2.1	-2.0	-1.4	1.2	1.4	1.9	0.6	-0.3	-0.5	-0.8
Extensor digitorum longus weight	1.6	6.3	27.2	-5.2	1.3	-3.0	-2.8	-1.7	1.4	1.4	1.7	-0.7	-3.2	2.4	-1.8
Bone: elastic displacement	0.1	0.1	0.5	-0.1	-0.6	0.3	0.4	0.1	-0.3	-0.3	-0.5	-0.2	-0.5	0.7	-0.0
Bone: elastic work	1.0	1.4	2.2	0.5	-0.5	1.1	1.2	1.3	-1.3	-1.3	-1.4	-1.5	-1.0	1.4	1.1
Bone: endosteal estimation	0.5	1.2	4.9	-2.2	0.2	-1.6	-1.5	-0.6	0.7	0.6	1.2	-0.4	-1.2	0.7	-0.7
Bone: endosteal perimeter	0.6	1.5	5.3	-2.3	-0.0	-1.1	-1.0	0.3	0.0	0.0	0.4	-1.6	-2.2	1.8	-0.0
Epididymis fat weight	0.0	0.2	1.0	0.2	-0.7	0.1	-0.1	-0.1	0.3	0.3	0.4	0.6	1.0	-0.7	-0.3
Delta time in closed arm before/after self-admin	0.3	0.3	0.5	0.5	-0.1	0.5	0.6	0.3	-0.7	-0.7	-0.5	-0.4	-0.4	0.4	0.7
Delta time in open arm before/after self-admin	0.8	1.0	3.0	0.3	1.0	-0.3	-0.5	-0.9	0.9	0.9	0.7	1.3	1.7	-1.5	-0.7
Diff in mean of infusions in LGA sessions	1.0	1.8	4.1	-0.1	-0.6	1.0	1.1	1.2	-1.5	-1.5	-1.4	-1.7	-1.7	2.0	0.9
Delay discount exponential model param	0.4	0.6	1.3	-0.1	0.5	-0.5	-0.6	-0.9	0.5	0.7	0.9	1.1	1.1	-1.1	-0.7
Extinction: sum of active levers before priming	0.8	1.2	3.1	-0.6	0.3	-0.9	-1.1	-1.7	0.9	1.0	1.5	1.7	0.6	-1.1	-0.8
Active lever presses in extinction session 6	0.3	0.3	1.5	-0.7	0.1	-0.5	-0.5	-1.2	0.4	0.2	0.4	0.7	-0.1	0.1	-0.6
Bone: final force	0.5	0.7	2.6	-0.6	0.9	-0.1	-0.0	0.9	-0.6	-0.6	-0.2	-1.6	-1.3	1.1	0.9
Bone: final moment	0.7	1.1	3.5	-0.4	1.2	0.1	0.2	1.2	-0.8	-0.8	-0.5	-1.9	-1.5	1.2	1.3
Food consumed during 24 hour testing period	1.0	2.0	3.9	-1.7	0.6	-2.0	-1.8	-1.5	1.7	1.6	1.6	0.9	-0.3	-0.5	-1.3
Glucose	1.2	1.9	3.6	-1.2	0.5	-1.5	-1.4	-1.9	1.7	1.6	1.2	1.6	0.3	-0.8	-1.7
Heart weight	0.5	0.8	4.6	-0.6	-2.1	0.3	0.4	0.7	-0.6	-0.6	-0.6	-0.7	-0.6	1.3	-0.3
Delay discount hyperbolic model param	0.6	0.8	1.4	-0.3	0.4	-0.7	-0.8	-1.0	0.7	0.9	1.1	1.2	1.2	-1.2	-0.9
Intermittent access intake day 1-15 change	0.2	0.9	2.1	-0.4	1.3	-1.0	-0.9	-0.9	1.4	0.9	0.7	0.8	0.6	-1.1	-0.9
Intermittent access intake escalation	0.1	0.6	2.0	-0.5	1.4	-0.9	-0.8	-0.7	1.2	0.6	0.5	0.4	0.4	-0.7	-0.7
Intermittent access intake escalation 2	0.2	0.4	1.4	-0.9	1.2	-0.9	-0.7	-0.4	0.5	0.5	0.4	-0.2	-0.7	0.1	-0.2
Intermitt. access day 1 inactive lever presses	0.0	0.4	1.2	0.8	1.1	0.4	0.6	0.9	-0.2	-0.2	-0.6	-0.8	-0.2	0.1	0.6
Intermitt. access day 15 inactive lever presses	0.0	0.2	0.9	-0.6	0.9	-0.4	-0.3	-0.3	0.5	0.1	0.1	-0.3	-0.4	0.4	-0.2
Intermitt. access escalation Index	0.2	0.6	2.0	-0.4	-1.4	0.3	0.2	0.5	-0.6	-0.3	-0.2	-0.8	-1.4	1.1	0.5
Intermittent access day 1 total infusions	0.1	0.3	1.1	1.1	0.8	0.4	0.3	0.0	-0.2	-0.2	-0.2	0.3	0.8	-0.9	0.6
Intermittent access day 15 total infusions	0.1	0.3	0.8	0.9	0.9	0.3	0.3	0.2	0.2	-0.3	-0.4	0.0	0.8	-0.7	0.4
Intermittent access terminal intake (last 3 days)	0.2	0.4	1.1	0.8	1.1	0.5	0.6	0.6	-0.4	-0.6	-0.8	-0.6	0.0	-0.1	0.9
Intermittent access total infusions	0.3	0.4	1.5	0.5	1.2	-0.3	-0.3	-0.4	0.4	0.4	0.2	0.5	0.9	-1.0	0.1
Intermittent access day 1 locomotion	0.4	0.7	2.6	1.6	0.6	0.9	0.8	0.4	-0.2	-0.6	-0.6	0.1	1.2	-0.9	0.7
Intermittent access day 15 total locomotion	0.1	0.5	2.5	0.8	1.6	0.4	0.5	0.5	-0.4	-0.6	-0.5	-0.5	0.1	-0.1	1.0
Intermittent access total locomotion	0.2	0.2	1.3	-0.0	1.1	-0.3	-0.3	-0.4	0.4	0.3	0.2	0.2	0.4	-0.4	-0.0
Intermittent access standard deviation	0.1	0.7	3.7	-0.4	1.9	-0.9	-0.8	-1.0	0.7	0.6	0.8	0.6	-0.0	-0.7	-0.1
Left kidney weight	0.5	3.6	11.2	-3.3	1.4	-2.7	-2.4	-1.6	1.8	2.0	1.7	0.1	-1.4	0.7	-1.6
Right kidney weight	0.6	4.5	10.8	-3.3	0.6	-2.8	-2.7	-2.2	2.2	2.4	2.1	1.2	-0.1	-0.0	-2.6
Cocaine induced anxiety	0.4	1.1	1.4	0.6	-0.9	1.0	1.0	1.1	-1.2	-1.2	-1.0	-1.1	-1.2	1.1	1.2
Post-drug Anxiety	0.6	0.7	2.4	1.5	-1.5	1.0	0.8	0.2	-0.3	-0.5	-0.4	0.6	1.0	-0.8	0.2
Baseline Anxiety	2.0	3.3	8.8	0.6	-1.2	-0.6	-0.8	-1.9	1.6	1.6	1.3	2.7	3.0	-2.6	-1.9
Tail length	0.2	1.3	5.4	0.7	-1.0	0.2	-0.2	-1.1	0.3	0.5	0.8	1.9	2.3	-1.6	-0.8
Length with tail	0.0	0.2	0.5	-0.7	-0.3	-0.3	-0.5	-0.7	0.1	0.3	0.5	0.6	0.6	0.1	-0.4
Length without tail	0.4	2.1	7.5	-2.6	0.3	-0.9	-0.7	0.1	-0.2	-0.1	-0.2	-1.6	-2.7	2.7	0.2
Times rat made contact with spout	0.2	0.2	0.5	-0.2	0.6	-0.7	-0.4	-0.3	0.7	0.5	0.3	0.2	-0.6	-0.3	-0.4
Lifetime Intake	0.3	0.4	1.5	0.4	1.2	-0.2	-0.3	-0.4	0.3	0.4	0.3	0.5	0.9	-1.0	0.1
Liver weight, left	1.8	3.0	7.4	-2.7	0.0	-2.3	-2.0	-2.0	2.0	1.8	1.4	1.0	-0.7	0.3	-2.2
Liver weight, right	0.6	1.1	2.7	-1.6	1.1	-1.4	-1.3	-0.9	1.1	1.1	1.0	0.4	0.1	0.0	-1.2
Locomotor activity	1.2	1.9	7.5	-2.7	0.7	-1.7	-1.6	-1.0	0.8	0.9	1.0	-0.4	-1.9	1.3	-0.4
Locomotor testing distance	1.0	2.3	7.0	-2.6	1.2	-2.0	-1.8	-1.6	1.4	1.5	1.3	0.2	-1.3	0.7	-1.0
Locomotor testing rearing	0.2	0.8	1.9	-1.4	-0.2	-1.0	-0.9	-1.2	1.0	0.9	0.6	0.6	-0.2	0.2	-1.2
Locomotion in novel chamber	0.2	0.3	1.3	0.3	1.1	0.1	0.3	0.3	-0.4	-0.2	-0.7	-0.5	-0.8	0.4	0.6
Locomotion in novel chamber post-restriction	0.3	1.0	1.9	1.0	-0.7	1.2	1.2	1.0	-1.3	-1.4	-1.2	-0.7	0.2	0.7	0.9
Fecal boli incidents, locomotor time 1	0.3	0.9	1.5	0.8	-1.1	1.1	1.0	1.2	-1.2	-1.0	-0.8	-0.8	-0.4	0.6	1.0
Change in fecal boli incidents, locomotor task	2.2	2.3	5.3	-1.6	2.3	-2.0	-1.8	-1.7	1.6	1.6	1.6	0.9	-0.5	-0.7	-1.0
Time >=10cm from walls, locomotor time 1	0.5	0.6	1.6	-0.3	0.8	0.1	0.3	0.7	-0.2	-0.7	-0.7	-1.3	-1.2	1.1	0.4
Bouts of movement, locomotor time 1	0.1	0.2	0.8	-0.4	-0.8	-0.2	-0.2	0.1	-0.3	0.0	0.3	-0.2	-0.9	0.4	0.0
Total resting periods, locomotor time 1	0.1	0.1	0.5	-0.4	-0.6	-0.3	-0.4	0.0	-0.2	0.1	0.4	-0.1	-0.7	0.2	-0.1
Rest time, locomotor task time 1	0.6	0.9	2.9	0.1	0.1	0.4	0.4	0.9	-1.4	-1.0	-0.4	-1.1	-1.7	1.0	1.3
Distance moved, locomotor task time 1	0.2	0.6	2.7	0.5	-0.5	0.2	0.0	-0.8	0.7	0.4	0.2	1.1	1.6	-1.0	-0.6
Vertical activity count, locomotor time 1	0.0	0.3	1.1	0.6	-1.0	0.7	0.6	-0.0	0.1	-0.3	-0.5	0.2	0.6	-0.0	0.1
Time >=10cm from walls, locomotor time 2	0.1	0.3	1.8	-0.2	-0.4	-0.1	0.0	0.1	-0.0	-0.2	-0.2	-0.6	-1.4	0.7	0.3
Bouts of movement, locomotor time 2	0.2	0.8	2.5	-1.0	-1.6	-1.0	-0.9	-0.4	0.8	1.0	0.8	0.3	-0.2	-0.2	-1.2
Total resting periods, locomotor time 2	0.3	1.0	2.1	-1.2	-1.5	-1.2	-1.2	-0.6	0.9	1.2	1.1	0.6	-0.1	-0.4	-1.4
Rest time, locomotor task time 2	0.1	0.1	0.4	0.2	-0.1	0.0	0.1	0.4	-0.6	-0.3	0.2	-0.2	-0.5	0.1	0.6
Distance moved, locomotor task time 2	0.6	0.8	2.3	0.1	-0.7	-0.1	-0.4	-1.2	0.9	0.7	0.6	1.4	1.5	-1.1	-0.9
Vertical activity count, locomotor time 2	0.2	0.6	1.7	0.8	-0.9	0.3	0.1	-0.7	0.5	0.4	0.2	1.0	1.3	-1.2	-0.2
Light reinforcement 1	0.3	1.4	5.7	-1.9	-1.2	-0.7	-0.5	-0.6	-0.0	-0.0	0.2	-0.5	-2.4	2.0	-0.2
Light reinforcement 2	0.1	0.3	1.3	0.2	1.0	-0.0	0.1	-0.2	-0.4	-0.2	-0.1	-0.0	-1.2	0.3	0.9
Bone: marrow area	0.5	1.3	5.0	-2.2	0.3	-1.6	-1.5	-0.6	0.7	0.6	1.1	-0.4	-1.3	0.8	-0.6
Bone: maximum diameter	1.0	2.0	5.8	-2.4	1.8	-1.8	-1.6	-0.5	0.7	0.6	1.1	-1.0	-2.1	1.1	0.1
Bone: maximum force	0.4	0.9	3.0	-0.6	0.8	0.0	0.0	1.0	-0.8	-0.7	-0.3	-1.7	-1.3	1.2	1.0
Bone: maximum moment	0.6	1.2	3.9	-0.4	1.2	0.2	0.2	1.2	-0.9	-0.9	-0.5	-2.0	-1.5	1.3	1.3
Mean time between licks in bursts	0.1	0.3	0.6	0.8	-0.6	0.7	0.7	0.3	-0.4	-0.4	-0.7	-0.0	0.8	-0.0	0.2
Mean num. licks in bursts	0.4	1.1	4.1	-1.5	1.6	-1.0	-0.7	-0.0	0.3	0.2	0.3	-0.9	-2.0	1.2	0.2
Cd content in liver	1.7	1.8	5.6	1.5	-2.4	1.7	1.6	1.2	-1.3	-1.2	-1.5	-0.7	-0.1	0.5	0.9
Co content in liver	2.8	3.3	4.9	1.4	-1.2	1.9	2.0	2.1	-2.2	-2.0	-2.0	-1.7	-1.2	1.7	1.9
Cu content in liver	0.6	0.7	1.2	0.2	0.6	0.7	0.7	1.0	-0.9	-0.7	-0.8	-1.1	-0.9	1.0	0.8
Fe content in liver	0.8	1.0	1.7	-0.8	0.1	-1.2	-1.2	-1.0	1.2	1.2	1.3	0.9	-0.1	-0.9	-1.0
K content in liver	0.1	0.1	0.7	-0.8	0.3	-0.3	-0.4	-0.4	0.1	0.4	0.3	0.2	-0.1	0.4	-0.3
Mg content in liver	0.1	0.1	0.7	-0.8	-0.3	-0.2	-0.3	-0.3	0.1	0.3	0.1	0.0	-0.1	0.6	-0.4
Mn content in liver	1.0	1.1	3.6	-0.4	1.9	-0.0	0.1	0.7	-0.7	-0.5	-0.4	-1.4	-1.7	1.2	1.3
Na content in liver	1.6	1.8	5.5	-2.3	-0.3	-1.7	-1.8	-1.4	1.1	1.3	1.6	0.6	-0.6	0.3	-1.3
Rb content in liver	0.9	1.0	1.6	-1.1	0.7	-1.1	-1.2	-1.2	1.1	1.1	1.3	0.9	0.2	-0.6	-0.9
Se content in liver	0.6	0.7	1.5	-0.1	0.3	-0.6	-0.8	-1.1	0.8	1.1	1.0	1.2	0.8	-1.2	-0.5
Sr content in liver	0.6	0.5	2.6	0.8	-1.6	0.9	0.6	0.5	-0.6	-0.6	-0.4	0.1	0.3	-0.1	0.4
Zn content in liver	1.0	1.1	2.5	0.4	-0.5	1.1	1.2	1.1	-1.1	-0.8	-1.6	-1.1	-0.9	1.5	0.7
Bone: minimum diameter	1.5	2.8	7.5	0.0	1.0	0.7	0.9	2.1	-1.5	-1.5	-1.2	-2.7	-2.4	1.9	2.0
Time in familiar zone, hab. session 1	0.6	0.6	1.3	0.1	-0.5	0.5	0.6	0.8	-0.9	-0.9	-0.7	-1.0	-0.8	1.1	0.8
Time in novel zone, hab. session 1	0.3	0.3	1.3	0.2	1.1	-0.2	-0.3	-0.5	0.6	0.5	0.5	0.6	0.4	-0.9	-0.2
Total zone transitions, hab. session 1	0.7	1.0	2.6	0.1	-0.4	-0.6	-0.6	-1.3	1.0	1.1	1.0	1.6	0.9	-1.4	-1.0
Total locomotion distance, hab. session 1	0.7	0.9	2.4	-0.0	0.0	-0.6	-0.6	-1.2	1.1	1.1	0.7	1.6	1.0	-1.1	-1.2
Locomotion velocity, hab. session 1	0.7	1.0	2.1	-0.3	0.2	-0.8	-0.8	-1.2	1.2	1.2	0.8	1.4	0.9	-1.0	-1.3
Time in familiar zone, hab. session 2	0.4	0.4	1.1	0.1	0.1	-0.3	-0.3	-0.8	0.5	0.7	0.4	1.1	1.0	-0.8	-0.6
Time in novel zone, hab. session 2	0.4	0.5	1.5	-0.3	1.2	-0.1	0.0	0.6	-0.2	-0.4	-0.3	-1.1	-1.2	0.7	0.7
Total zone transitions, hab. session 2	0.3	0.3	2.6	0.1	-1.6	0.5	0.5	0.0	-0.2	-0.1	-0.5	0.3	-0.0	0.4	-0.6
Total locomotion distance, hab. session 2	0.3	0.4	2.5	0.0	-1.6	0.5	0.6	0.5	-0.3	-0.3	-0.9	-0.2	-0.1	0.7	-0.6
Locomotion velocity, hab. session 2	0.3	0.4	1.6	0.2	-1.3	0.6	0.7	0.7	-0.5	-0.5	-1.0	-0.4	-0.2	0.8	-0.3
Novel to familiar place preference ratio	0.5	0.7	2.5	-0.7	0.1	0.2	0.1	0.8	-0.7	-0.6	-0.3	-1.3	-1.6	1.2	0.6
Novelty place preference	0.6	0.8	3.1	-0.7	0.5	0.1	0.1	0.8	-0.7	-0.6	-0.4	-1.4	-1.8	1.3	0.7
Time in novel zone, NPP test	0.6	0.8	3.3	-1.0	0.8	-0.2	-0.2	0.5	-0.5	-0.4	-0.1	-1.3	-1.8	1.2	0.6
Total zone transitions, NPP test	0.3	0.4	2.4	-0.4	-1.5	-0.4	-0.3	-0.5	0.5	0.6	0.1	0.5	-0.0	0.0	-1.1
Total locomotion distance, NPP test	0.5	0.7	2.3	-0.6	-0.8	-0.7	-0.7	-0.8	1.0	1.0	0.6	0.9	0.6	-0.5	-1.5
Locomotion velocity, NPP test	0.6	0.8	2.1	-0.2	-1.2	-0.5	-0.5	-0.8	0.9	0.9	0.5	1.2	1.1	-0.8	-1.4
Intraocular pressure	0.1	0.1	0.6	0.1	-0.5	0.2	0.1	0.0	-0.2	-0.4	-0.0	0.2	0.8	-0.1	-0.1
Delta distance traveled before/after self-admin	1.9	2.1	5.6	-2.0	2.4	-1.9	-1.7	-1.2	1.4	1.4	1.4	0.5	-0.4	-0.2	-1.1
Delta ambulatory time before/after self-admin	1.0	1.8	9.7	-1.6	3.1	-1.6	-1.4	-0.9	1.0	1.1	1.0	0.2	-0.4	-0.0	-0.6
Parametrial fat weight	0.4	0.9	3.1	1.6	-1.1	0.8	0.6	-0.2	-0.3	0.0	-0.2	1.3	1.8	-1.2	0.0
Pavlov. Cond. lever latency	1.0	1.3	7.8	-0.5	2.8	-1.1	-1.0	-0.8	1.2	1.1	0.8	0.5	0.1	-0.8	-0.4
Pavlov. Cond. magazine entry latency	9.9	12.7	18.6	2.8	-4.3	4.0	4.0	4.2	-4.0	-4.0	-3.8	-3.3	-1.0	2.8	3.0
Pavlov. Cond. change in total contacts	3.6	3.9	5.5	1.3	-2.3	2.2	2.1	2.3	-2.3	-2.3	-2.1	-1.9	-0.8	1.8	1.6
Pavlov. Cond. index score	5.1	6.5	17.6	2.2	-4.2	3.0	2.8	2.7	-2.8	-2.8	-2.5	-1.8	-0.1	1.6	1.8
Pavlov. Cond. latency score	3.7	4.7	16.3	1.8	-4.0	2.6	2.4	2.1	-2.4	-2.3	-2.0	-1.3	-0.0	1.3	1.4
Pavlov. Cond. lever contacts	2.2	2.6	9.1	1.0	-3.0	1.7	1.6	1.6	-1.9	-1.8	-1.4	-1.2	-0.4	1.3	1.0
Pavlov. Cond. magazine entry number	8.6	10.9	15.8	-2.8	3.9	-3.8	-3.7	-4.0	3.7	3.7	3.6	3.0	0.8	-2.4	-2.8
Pavlov. Cond. intertrial magazine entries	2.7	3.2	6.1	-0.6	1.5	-1.3	-1.5	-2.2	1.8	1.8	1.7	2.5	1.8	-2.0	-2.1
Pavlov. Cond. lever-magazine prob. diff.	5.2	6.4	18.1	2.1	-4.2	2.9	2.8	2.7	-2.8	-2.7	-2.5	-1.8	-0.2	1.7	1.8
Pavlov. Cond. response bias	7.9	9.8	14.5	2.3	-3.7	3.5	3.4	3.8	-3.6	-3.6	-3.3	-3.1	-1.1	2.6	2.6
Pavlov. Cond. lever latency	1.1	1.5	2.7	-1.0	1.1	-1.3	-1.3	-1.7	1.5	1.3	1.3	1.3	0.3	-1.0	-1.1
Pavlov. Cond. magazine entry latency	0.7	1.0	3.8	2.0	-0.5	1.3	1.3	0.7	-0.8	-0.8	-1.1	0.2	0.9	-0.4	0.8
Pavlov. Cond. change in total contacts	0.3	0.7	1.3	1.2	-0.7	1.2	1.0	1.0	-1.1	-0.8	-0.9	-0.4	0.3	0.2	0.8
Pavlov. Cond. index score	0.6	1.0	1.9	1.4	-0.8	1.3	1.2	1.1	-1.2	-1.0	-1.1	-0.4	0.5	0.2	0.9
Pavlov. Cond. latency score	0.3	0.5	1.1	1.0	-0.5	0.9	0.9	0.8	-0.9	-0.7	-0.8	-0.2	0.4	0.2	0.7
Pavlov. Cond. lever contacts	0.8	1.1	2.0	0.9	-1.2	1.1	1.1	1.4	-1.3	-1.2	-1.1	-1.0	-0.1	0.8	1.0
Pavlov. Cond. magazine entry number	0.7	1.0	3.7	-1.9	0.4	-1.3	-1.2	-0.9	0.8	0.7	0.9	-0.1	-1.0	0.6	-0.8
Pavlov. Cond. intertrial magazine entries	0.5	1.0	1.7	-1.1	0.3	-1.1	-1.1	-1.2	1.1	1.0	1.2	1.0	0.7	-0.7	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.1	2.2	1.5	-1.0	1.4	1.3	1.1	-1.2	-1.0	-1.1	-0.3	0.6	0.1	0.9
Pavlov. Cond. response bias	2.1	2.9	4.4	1.9	-1.7	2.1	2.0	2.1	-1.9	-1.8	-1.9	-1.2	0.2	0.8	1.5
Time in closed arm before self-admin	0.5	0.9	1.8	0.7	-0.0	0.9	1.0	1.3	-0.9	-1.1	-1.2	-1.2	-0.5	0.8	0.8
Time in closed arm after self-admin	0.2	0.2	0.4	0.6	-0.1	0.6	0.6	0.5	-0.5	-0.6	-0.6	-0.4	-0.2	0.3	0.5
Time in open arm before self-admin	0.3	0.4	1.5	-1.2	-0.2	-0.7	-0.6	-0.4	-0.0	0.2	0.4	-0.3	-0.9	0.8	-0.1
Time in open arm after self-admin	0.3	0.3	0.9	-0.8	0.9	-0.8	-0.8	-0.5	0.5	0.6	0.6	0.1	-0.1	-0.0	-0.3
Bone: periosteal estimation	0.6	1.4	4.0	-2.0	1.5	-1.5	-1.3	-0.2	0.5	0.4	0.9	-1.0	-1.7	0.9	0.1
Bone: periosteal perimeter	0.6	1.3	3.8	-2.0	1.5	-1.3	-1.2	-0.1	0.3	0.4	0.8	-1.1	-1.7	1.0	0.2
Bone: post-yield work	0.0	0.1	0.2	-0.2	0.0	0.1	-0.0	0.4	-0.3	-0.3	0.1	-0.4	0.3	0.2	-0.0
Progressive ratio test 1 active lever presses	0.2	0.3	1.0	0.5	0.5	-0.1	-0.2	-0.5	0.5	0.3	0.2	0.7	1.0	-1.0	-0.2
Progressive ratio test 1 breakpoint	0.2	0.3	1.0	0.5	0.4	-0.1	-0.2	-0.5	0.5	0.3	0.1	0.7	1.0	-1.0	-0.1
Progressive ratio test 1 inactive lever presses	0.7	1.9	6.2	1.2	1.7	-0.3	-0.4	-0.9	1.3	1.2	0.7	1.5	2.2	-2.5	-0.6
Progressive ratio test 2 active lever presses	0.3	0.4	1.8	-0.6	1.3	-0.8	-0.7	-0.5	0.7	0.5	0.4	0.1	-0.2	-0.2	-0.3
Progressive ratio test 2 breakpoint	0.3	0.4	1.7	-0.6	1.3	-0.8	-0.7	-0.5	0.7	0.5	0.4	0.1	-0.1	-0.2	-0.3
Progressive ratio test 2 inactive lever presses	0.1	0.4	4.0	0.2	2.0	-0.2	-0.1	-0.0	0.3	0.3	0.0	-0.3	-0.1	-0.3	0.5
Incentive Sensitization - Responses	0.3	0.8	2.8	-1.0	1.3	-0.5	-0.2	0.5	0.2	0.0	-0.2	-1.4	-1.7	1.2	0.2
Incentive Sensitization - Breakpoint	0.3	0.7	2.5	-0.9	1.2	-0.5	-0.1	0.6	0.1	-0.0	-0.2	-1.4	-1.6	1.2	0.2
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.0	-0.5	0.7	-0.7	-0.8	-1.0	0.5	0.6	1.0	0.8	0.4	-0.6	-0.4
Progressive ratio	1.3	3.9	5.5	1.5	-1.8	2.2	2.2	2.1	-2.3	-2.3	-2.2	-1.7	-1.1	1.7	1.9
Food seeking constrained by brief footshock	2.0	2.5	4.5	-1.0	-0.3	-1.5	-1.6	-2.1	1.9	1.7	1.8	2.0	0.7	-1.4	-1.6
Seeking ratio, punishment vs. effort	3.4	7.6	11.1	-2.9	1.2	-3.3	-3.3	-3.2	3.3	3.2	3.1	2.4	1.0	-1.8	-3.0
Retroperitoneal fat weight	0.4	1.7	4.2	0.3	-1.2	-0.6	-0.7	-1.4	1.1	1.3	1.1	2.0	1.8	-1.8	-1.2
Reaction time number correct	0.2	0.7	1.6	-1.3	0.1	-1.0	-0.9	-0.9	1.2	0.9	0.7	0.4	-0.0	-0.1	-1.1
Reaction time mean minus median	0.1	0.5	1.4	0.3	0.1	-0.3	-0.5	-0.9	0.6	0.7	0.8	1.2	0.7	-1.2	-0.4
Reaction time mean minus median AUC	0.2	1.1	3.3	0.6	0.7	-0.4	-0.6	-1.3	0.7	0.9	1.2	1.7	1.1	-1.8	-0.4
Reaction time num false alarms	0.2	0.4	1.5	0.4	0.1	-0.1	-0.3	0.0	0.7	0.6	0.4	0.4	1.2	-1.2	-0.4
Reaction time num false alarms AUC	0.5	1.0	2.5	-0.1	0.4	-0.8	-1.0	-0.6	1.3	1.2	1.1	0.8	1.4	-1.6	-0.9
Reaction time trials correct on left	0.2	0.7	1.6	-1.3	0.1	-1.0	-0.9	-0.9	1.2	0.9	0.7	0.4	-0.0	-0.1	-1.1
Reaction time trials on left	0.2	0.8	1.6	-1.3	0.1	-1.0	-1.0	-0.9	1.2	0.9	0.8	0.5	0.0	-0.1	-1.1
Reaction time mean	0.3	0.6	3.1	1.8	-0.3	0.9	0.8	0.2	-0.4	-0.4	-0.4	0.6	0.8	-1.1	0.6
Reaction time mean AUC	0.2	0.6	2.7	1.6	-0.6	0.8	0.6	0.0	-0.3	-0.3	-0.1	0.8	0.8	-1.2	0.6
Median of all reaction times	0.7	1.2	5.0	2.2	-0.5	1.3	1.3	0.8	-0.8	-0.9	-0.9	0.2	0.7	-0.8	1.1
Reaction time omissions	0.5	0.8	1.8	-0.3	-0.8	-0.5	-0.8	-1.3	0.7	0.8	1.0	1.3	0.8	-1.1	-0.9
Reaction time false alarm rate	0.3	0.4	1.8	0.7	0.3	-0.1	-0.2	-0.0	0.4	0.5	0.5	0.5	1.3	-1.3	-0.2
Reaction time premature initiation rate	0.4	0.6	1.5	-0.9	-0.2	-0.7	-0.7	-1.2	0.8	0.7	0.7	1.0	0.1	-0.2	-1.1
Reaction time premature initiations	0.3	0.9	1.9	-1.4	0.1	-1.0	-1.0	-1.3	1.1	0.9	0.9	0.9	-0.2	-0.1	-1.3
Std. dev. reaction times	0.2	0.6	2.1	1.1	-0.2	0.3	0.1	-0.5	0.2	0.2	0.4	1.1	1.2	-1.4	0.1
Reaction time trials completed	0.2	0.8	1.6	-1.3	0.1	-1.0	-1.0	-0.9	1.2	0.9	0.8	0.5	0.0	-0.1	-1.1
Reaction time trials AUC	0.2	0.6	1.3	-1.1	0.1	-0.9	-0.9	-0.9	1.1	0.8	0.7	0.5	0.1	-0.1	-1.1
Run reversals in cocaine runway, females	0.4	0.5	0.8	-0.5	0.3	-0.8	-0.9	-0.6	0.8	0.8	0.8	0.6	0.6	-0.8	-0.8
Run reversals in cocaine runway, males	0.5	0.6	1.1	-0.3	-0.5	-0.4	-0.6	-0.8	0.9	0.6	0.8	1.1	0.8	-0.9	-0.9
Latency to leave start box in cocaine runway	0.6	0.8	2.4	-1.5	-0.4	-1.2	-1.2	-0.8	0.7	0.9	1.1	0.3	-0.8	0.2	-0.8
Latency to leave start box in cocaine runway, F	1.0	1.3	2.2	-1.0	-0.4	-1.1	-1.3	-1.4	1.1	1.2	1.5	1.3	0.7	-0.9	-1.3
Latency to leave start box in cocaine runway, M	1.4	1.4	6.0	-2.0	0.0	-1.1	-0.9	0.3	0.1	0.4	0.3	-1.2	-2.4	1.6	-0.2
Std. dev. time between licks in bursts	0.4	0.8	1.8	0.2	-1.3	1.0	0.9	1.0	-1.0	-1.0	-1.2	-1.0	-0.0	1.0	0.2
Total sessions with >9 infusions	1.5	1.8	4.5	0.5	1.7	-0.7	-0.7	-1.4	1.3	1.0	1.0	1.7	2.1	-2.1	-0.8
Short access day 1 total inactive lever presses	0.5	1.0	7.8	-0.1	2.8	-0.8	-0.7	-0.5	0.9	0.7	0.7	0.2	0.6	-1.0	0.1
Short access day 10 total inactive lever presses	0.0	0.2	0.5	0.3	0.7	-0.1	-0.1	-0.0	0.6	0.6	0.3	0.1	0.5	-0.7	-0.1
Short access day 1 total infusions	0.3	0.7	3.0	-0.0	1.7	-0.6	-0.7	-0.7	0.6	0.5	0.8	0.7	1.0	-1.0	-0.1
Short access day 10 total infusions	0.3	0.5	1.9	1.4	0.9	0.5	0.5	0.2	-0.3	0.0	-0.2	0.4	1.3	-1.1	0.6
Short access total infusions	0.6	0.8	3.0	0.9	1.2	0.0	-0.1	-0.6	0.3	0.4	0.4	1.0	1.7	-1.6	-0.0
Short access day 1 locomotion	0.0	0.1	0.2	0.2	0.4	0.2	0.2	-0.1	-0.2	-0.3	-0.1	-0.0	0.2	0.1	0.4
Short access day 10 total locomotion	0.2	1.0	3.9	-0.1	2.0	-0.8	-0.8	-1.0	0.9	1.0	0.9	1.0	0.9	-1.1	-0.4
Short access total locomotion	0.3	0.4	2.0	0.6	1.4	-0.0	-0.1	-0.5	0.4	0.3	0.3	0.6	1.0	-0.9	0.2
One hour access (0.3 mA shock)	0.6	0.7	3.1	-1.0	1.8	-0.8	-0.6	-0.2	-0.2	0.3	0.3	-0.6	-1.5	0.7	0.4
Compulsive drug intake	1.0	1.4	4.0	-1.3	2.0	-1.5	-1.3	-1.3	1.0	1.1	1.4	0.6	-0.6	-0.3	-0.8
One hour access (shock baseline)	0.1	0.3	0.8	0.4	-0.1	0.5	0.5	0.6	-0.9	-0.4	-0.7	-0.7	-0.4	0.4	0.9
Social response proportion	1.1	1.5	3.2	-0.1	0.4	0.6	0.7	1.2	-1.3	-1.3	-1.0	-1.8	-1.6	1.6	1.5
Social responses	0.0	0.1	0.2	-0.1	-0.5	0.1	0.1	0.1	-0.1	-0.2	-0.1	-0.3	-0.4	0.3	0.2
Social time	0.6	0.9	1.6	-0.7	0.9	-1.1	-1.1	-1.3	0.9	1.0	1.2	0.9	0.2	-0.8	-0.5
Soleus weight	3.6	10.5	42.8	-6.5	1.2	-4.2	-3.9	-2.5	2.2	2.4	2.6	-0.3	-3.4	2.5	-2.8
Bone: stiffness	0.8	1.5	2.8	-1.4	0.9	-1.6	-1.7	-1.2	1.3	1.3	1.7	0.6	0.5	-0.9	-0.9
Tibialis anterior weight	4.2	14.5	48.5	-7.0	2.4	-5.1	-4.8	-3.6	3.4	3.3	3.5	0.6	-2.9	1.5	-3.4
Time to tail flick, vehicle, before self-admin	0.9	1.1	7.9	1.1	-2.8	1.2	1.0	0.6	-0.7	-0.7	-0.6	0.2	0.6	-0.1	-0.1
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.8	0.0	0.9	-0.1	0.0	0.3	-0.1	-0.2	-0.2	-0.5	-0.2	0.1	0.3
Time to tail flick, test, before self-admin	4.0	4.6	7.0	1.9	-1.5	2.5	2.5	2.6	-2.4	-2.4	-2.5	-2.2	-0.7	1.6	2.1
Time to tail flick, test, after self-admin	0.4	0.5	2.0	1.4	-0.2	0.8	0.6	0.2	-0.4	-0.2	-0.2	0.6	1.0	-0.9	0.6
Delta time to tail flick, vehicle, before/after SA	0.3	0.4	3.3	-0.2	1.8	-0.6	-0.4	-0.2	0.4	0.3	0.2	-0.1	-0.2	-0.2	0.3
Delta time to tail flick, test, before/after SA	1.3	1.6	2.8	-0.9	1.7	-1.5	-1.4	-1.6	1.3	1.5	1.5	1.2	0.0	-1.0	-0.7
Tibia length	0.8	2.1	4.8	-0.0	0.1	0.6	0.9	1.7	-1.5	-1.6	-1.2	-2.2	-1.7	2.0	1.8
Ambulatory time before self-admin	0.0	0.1	0.4	0.4	-0.4	0.0	-0.1	-0.1	-0.0	-0.0	0.3	0.2	0.5	-0.6	0.1
Ambulatory time after self-admin	1.1	1.8	5.8	-1.5	2.4	-1.8	-1.7	-1.2	1.1	1.2	1.5	0.4	-0.1	-0.6	-0.7
Bone: tissue strength	0.3	0.3	0.9	0.9	0.3	0.6	0.6	0.6	-0.3	-0.5	-0.4	-0.3	-0.0	-0.2	0.7
Total heroin consumption	0.5	0.6	1.8	-0.9	-0.4	-0.7	-0.8	-1.4	0.3	0.5	0.9	0.9	0.3	-0.3	-0.9
Bone: trabecular number	0.5	1.0	2.2	1.5	-1.0	1.4	1.3	1.1	-0.9	-0.9	-1.1	-0.3	0.4	-0.2	0.6
Bone: trabecular spacing	0.1	0.1	0.2	-0.3	-0.1	-0.5	-0.4	-0.4	0.2	0.2	0.5	0.3	0.2	-0.1	-0.2
Bone: trabecular thickness	0.3	0.4	3.4	-0.1	1.8	-0.2	-0.1	0.0	0.2	0.2	-0.1	-0.4	-1.0	0.2	0.5
Bone: trabecular tissue density	2.4	4.2	11.2	-3.3	3.3	-2.7	-2.5	-1.8	1.4	1.6	1.9	-0.2	-1.6	0.8	-0.6
Water consumed over 24 hours	0.0	0.1	0.3	0.3	0.1	0.1	0.3	0.4	-0.2	-0.3	-0.3	-0.3	-0.5	0.2	0.3
Number of responses in last shaping day	0.0	0.0	0.2	-0.1	0.3	-0.1	-0.0	0.1	0.5	0.1	-0.2	-0.2	0.1	0.0	-0.1