Hub : Genes

Rfc3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Rfc3 0.03 0.02 7.6e-04 0.02 0.02 0.01 0.02 2.9e-03 3.7e-03 5.2e-02 2.9e-03
2 NAcc gene expression Rfc3 0.12 0.06 0.0e+00 0.15 0.16 0.14 0.15 3.8e-22 7.9e-23 2.8e-21 4.6e-22
3 Brain gene expression Rfc3 0.28 0.12 0.0e+00 0.38 0.38 0.38 0.38 1.2e-36 2.6e-37 9.2e-37 7.4e-37
4 PL gene expression Rfc3 0.33 0.13 0.0e+00 0.41 0.42 0.42 0.42 6.0e-48 2.6e-49 6.6e-49 4.1e-49
5 pVTA gene expression Rfc3 0.08 0.05 1.1e-06 0.09 0.09 0.08 0.09 1.3e-07 1.6e-07 3.5e-07 1.3e-07
6 IC gene expression Rfc3 0.41 0.16 5.6e-17 0.37 0.38 0.37 0.38 2.3e-16 3.2e-17 1.2e-16 8.9e-17
7 Adipose gene expression Rfc3 0.07 0.04 7.9e-08 0.06 0.06 0.06 0.06 3.1e-07 4.0e-07 9.7e-07 3.6e-07
8 IL gene expression Rfc3 0.33 0.14 6.4e-07 0.28 0.27 0.28 0.28 1.7e-07 3.0e-07 2.0e-07 2.3e-07
9 BLA gene expression Rfc3 0.35 0.14 0.0e+00 0.28 0.29 0.29 0.3 3.3e-15 6.9e-16 6.5e-16 1.3e-16
10 OFC gene expression Rfc3 0.33 0.14 3.1e-07 0.18 0.27 0.28 0.26 5.6e-05 3.2e-07 2.0e-07 5.7e-07
11 pVTA mRNA stability Rfc3 0.03 0.03 3.2e-03 0.01 0.02 0.02 0.01 7.5e-02 4.9e-03 1.1e-02 3.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density1.93.35.7-0.72.42.32.12.02.02.02.01.60.81.0
Area under the delay curve3.94.55.7-0.6-2.4-2.4-2.3-2.3-2.3-2.2-2.3-2.3-1.7-1.9
BMI with tail0.10.41.0-1.00.90.80.70.70.60.60.6-0.3-0.3-0.5
BMI without tail0.51.47.3-2.70.30.1-0.2-0.4-0.3-0.5-0.3-1.0-1.7-1.7
Body weight1.25.131.4-5.61.71.40.70.30.40.30.3-1.2-3.0-2.8
Weight adjusted by age0.60.91.5-0.11.21.21.11.01.01.01.11.00.50.6
Bone surface0.61.12.3-1.51.51.41.21.01.11.01.00.5-0.1-0.1
Bone volume0.91.62.8-0.51.71.61.51.41.41.41.40.90.60.6
Breakpoint value in progressive ratio session1.21.41.8-0.6-1.2-1.2-1.3-1.1-1.3-1.2-1.3-1.3-1.1-1.3
Number of licking bursts0.81.32.0-0.11.41.41.31.21.31.21.21.30.70.9
Context. condit. distance diff. score1.41.75.8-2.4-0.5-0.6-0.8-1.0-0.9-1.0-1.0-1.0-1.9-1.7
Locomotion velocity, session 10.60.71.0-0.1-1.0-1.0-0.9-0.9-0.9-0.9-0.9-0.7-0.6-0.6
Locomotion distance, session 10.20.30.60.6-0.8-0.7-0.6-0.6-0.6-0.5-0.6-0.2-0.00.0
Locomotion velocity, session 20.40.50.7-0.3-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.6-0.7-0.6
Locomotion distance, session 20.10.20.30.3-0.5-0.5-0.4-0.4-0.4-0.4-0.40.2-0.10.2
Locomotion velocity, session 30.30.30.5-0.7-0.4-0.4-0.5-0.5-0.5-0.5-0.5-0.5-0.7-0.6
Locomotion distance, session 30.40.50.80.40.70.70.70.70.70.70.70.90.60.8
Stereotopy head waving bouts, day 30.80.91.9-0.91.41.31.11.01.10.91.00.80.10.3
Stereotopy head waving duration, day 30.20.20.20.30.50.50.50.50.50.50.50.30.40.4
Locomotion velocity, session 73.13.44.4-0.6-2.1-2.1-2.0-1.9-2.0-2.0-1.9-2.0-1.5-1.6
Locomotion distance, session 71.52.02.4-0.9-1.4-1.5-1.5-1.5-1.5-1.6-1.5-1.2-1.4-1.3
Stereotopy head waving bouts, day 70.10.10.20.1-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.1-0.2-0.1
Stereotopy head waving duration, day 70.10.10.30.5-0.5-0.5-0.4-0.4-0.4-0.4-0.4-0.20.1-0.0
Locomotion velocity, session 80.70.91.0-0.8-0.8-0.9-0.9-0.9-0.9-0.9-0.9-1.0-1.0-1.0
Locomotion distance, session 80.71.02.6-1.6-0.6-0.7-0.8-0.9-0.8-0.8-0.9-0.9-1.4-1.2
Degree of sensitization distance1.71.72.4-0.3-1.5-1.5-1.5-1.4-1.4-1.5-1.4-1.2-1.0-1.0
Degree of sensitization stereotypy0.30.30.60.3-0.7-0.7-0.7-0.6-0.6-0.6-0.6-0.4-0.2-0.3
Conditioned locomotion0.60.70.80.60.90.90.90.80.90.90.90.80.80.9
Cocaine response after cond. corrected0.40.51.21.10.40.50.50.60.60.80.8-0.11.00.5
Cocaine response after cond. not corrected0.10.10.40.5-0.2-0.1-0.1-0.1-0.10.10.1-0.60.3-0.2
Cocaine response before conditioning1.51.82.4-1.4-1.2-1.3-1.3-1.4-1.4-1.4-1.4-1.0-1.5-1.3
Saline control response0.60.83.6-1.91.21.00.80.40.60.40.40.9-0.7-0.1
Bone: connectivity density1.21.93.8-1.82.01.81.61.31.41.31.31.0-0.10.1
Bone: cortical apparent density0.60.81.20.1-1.1-1.1-1.0-0.9-1.0-0.9-0.9-1.1-0.5-0.7
Bone: cortical area1.52.34.5-2.1-1.0-1.1-1.2-1.3-1.3-1.3-1.3-1.6-1.9-1.9
Bone: cortical porosity0.20.20.30.10.50.50.50.50.50.50.50.50.30.4
Bone: cortical porosity0.00.00.00.1-0.0-0.0-0.0-0.0-0.0-0.0-0.00.20.00.1
Bone: cortical thickness0.81.43.4-1.8-0.6-0.7-0.9-1.0-0.9-1.0-1.0-1.2-1.5-1.6
Bone: cortical thickness0.60.73.0-1.7-0.3-0.4-0.5-0.7-0.6-0.7-0.7-0.5-1.2-1.0
Bone: cortical tissue density0.40.61.00.2-1.0-0.9-0.9-0.8-0.8-0.8-0.8-0.9-0.4-0.6
Condit. Reinf. active minus inactive responses0.50.61.10.4-1.0-1.0-0.9-0.8-0.8-0.8-0.8-0.8-0.3-0.5
Condit. Reinf. active-inactive response ratio0.80.91.30.0-1.1-1.1-1.0-1.0-1.0-1.0-1.0-1.2-0.6-0.8
Condit. Reinf. active responses0.40.50.80.0-0.9-0.9-0.9-0.8-0.8-0.8-0.8-0.6-0.5-0.5
Condit. Reinf. inactive responses0.20.20.4-0.1-0.6-0.6-0.6-0.6-0.6-0.6-0.60.0-0.4-0.1
Incentive salience index mean0.30.40.70.3-0.9-0.8-0.8-0.7-0.7-0.7-0.7-0.5-0.3-0.3
Condit. Reinf. lever presses0.10.20.30.1-0.6-0.5-0.5-0.5-0.5-0.5-0.5-0.2-0.3-0.2
Condit. Reinf. active minus inactive responses2.33.04.9-2.2-1.3-1.4-1.5-1.9-1.6-1.6-1.6-1.5-2.1-2.0
Condit. Reinf. active-inactive response ratio2.22.53.3-1.7-1.4-1.5-1.5-1.8-1.6-1.6-1.6-1.4-1.8-1.7
Condit. Reinf. active responses2.53.55.9-2.4-1.4-1.5-1.7-2.0-1.8-1.8-1.8-1.6-2.3-2.1
Condit. Reinf. inactive responses0.20.31.0-1.0-0.2-0.2-0.3-0.4-0.4-0.4-0.4-0.3-0.7-0.6
Condit. Reinf. lever presses0.50.71.1-0.9-0.8-0.8-0.9-1.0-0.9-0.8-0.8-0.7-0.9-0.9
Condit. Reinf. lever reinforcers received2.63.65.1-2.2-1.5-1.6-1.7-2.1-1.8-1.9-1.9-1.5-2.3-2.1
Conditioned reinforcement - actives0.30.53.7-1.90.50.40.20.20.0-0.0-0.00.1-1.1-0.8
Conditioned reinforcement - inactives0.71.01.40.11.21.11.11.21.01.11.01.20.40.8
Conditioned locomotion0.50.74.1-2.00.1-0.0-0.2-0.0-0.3-0.4-0.4-0.3-1.2-1.0
Patch foraging indifference point 0 sec2.44.55.11.22.22.22.22.12.22.22.22.32.02.1
Patch foraging indifference point AUC0.30.40.9-0.70.90.90.80.40.70.60.60.7-0.10.2
Delay disc. indifference point, 0s delay4.14.57.5-1.9-2.1-2.1-2.1-2.1-2.0-2.1-2.0-2.7-1.7-2.3
Delay disc. indifference point, 16s delay1.21.31.8-0.3-1.2-1.2-1.2-1.3-1.2-1.2-1.3-1.1-1.0-1.0
Delay disc. indifference point, 2s delay5.76.38.9-0.2-3.0-2.9-2.8-2.6-2.7-2.5-2.7-2.9-1.6-2.2
Delay disc. indifference point, 24s delay0.80.91.30.2-1.1-1.1-1.1-1.1-1.0-1.1-1.0-0.9-0.6-0.6
Delay disc. indifference point, 4s delay3.13.24.5-0.4-2.1-2.0-2.0-1.9-1.9-1.9-1.9-2.1-1.4-1.6
Delay disc. indifference point, 8s delay1.31.62.2-0.5-1.3-1.4-1.3-1.5-1.3-1.3-1.4-1.1-1.2-1.1
Indifference point function ln k0.10.10.4-0.20.30.30.30.40.30.20.20.60.20.3
Indifference point function log k0.10.10.4-0.20.30.30.30.40.30.20.20.60.20.3
Patch foraging total patch changes 0 sec3.15.86.91.32.52.52.62.42.62.52.52.62.32.5
Patch foraging total patch changes 12 sec1.72.22.90.71.71.71.71.41.61.61.61.51.21.4
Patch foraging total patch changes 18 sec3.24.85.71.12.42.42.42.12.42.32.32.31.92.2
Patch foraging total patch changes 24 sec1.62.85.00.41.91.81.81.51.71.71.72.21.21.7
Patch foraging total patch changes 6 sec2.74.15.10.82.22.22.22.02.22.12.22.31.71.9
Patch foraging time to switch 0 sec0.81.74.71.4-1.7-1.5-1.4-0.9-1.2-1.1-1.0-2.20.1-0.8
Patch foraging water rate 0 sec2.04.17.4-1.22.72.52.31.92.12.01.92.70.61.4
Patch foraging water rate 12 sec0.10.31.1-0.60.70.60.50.40.50.40.41.0-0.00.3
Patch foraging water rate 18 sec0.40.71.2-1.1-0.7-0.8-0.8-0.9-0.8-0.9-1.0-0.2-0.9-0.7
Patch foraging water rate 24 sec0.50.72.1-1.41.11.00.80.40.70.50.51.0-0.50.0
Patch foraging water rate 6 sec0.40.51.0-1.00.90.80.70.60.70.70.51.00.20.5
Seeking ratio, delayed vs. immediate footshock2.22.75.01.91.11.21.41.71.51.61.51.52.21.9
Distance traveled before self-admin0.70.91.30.2-1.1-1.1-1.1-1.1-0.9-1.1-1.0-1.0-0.7-0.6
Distance traveled after self-admin0.20.30.60.0-0.5-0.6-0.6-0.7-0.6-0.8-0.6-0.1-0.7-0.3
Extensor digitorum longus weight0.72.818.3-4.30.60.4-0.1-0.5-0.3-0.4-0.5-0.8-2.4-2.2
Bone: elastic displacement0.10.10.2-0.30.50.40.40.30.30.30.30.30.00.1
Bone: elastic work0.50.72.4-1.51.11.00.80.60.70.60.60.5-0.4-0.2
Bone: endosteal estimation0.71.62.7-0.61.71.61.51.31.41.31.31.40.50.8
Bone: endosteal perimeter0.10.21.7-1.30.40.30.20.00.10.00.00.3-0.6-0.4
Epididymis fat weight0.00.10.2-0.2-0.2-0.2-0.2-0.4-0.3-0.3-0.3-0.1-0.3-0.3
Delta time in closed arm before/after self-admin1.31.22.1-0.6-0.9-1.0-1.1-1.3-1.0-1.2-1.1-1.1-1.4-1.2
Delta time in open arm before/after self-admin0.50.52.61.6-0.4-0.2-0.10.3-0.10.20.10.31.40.8
Diff in mean of infusions in LGA sessions0.00.00.1-0.30.00.0-0.00.2-0.10.0-0.10.1-0.1-0.2
Delay discount exponential model param4.55.06.50.42.52.52.52.42.42.42.42.41.81.9
Extinction: sum of active levers before priming0.40.50.70.2-0.9-0.8-0.8-0.8-0.8-0.8-0.7-0.6-0.3-0.5
Active lever presses in extinction session 60.10.10.10.00.30.30.30.20.20.10.30.30.00.2
Bone: final force0.50.84.6-2.10.1-0.1-0.3-0.4-0.4-0.4-0.4-0.7-1.3-1.2
Bone: final moment0.40.63.4-1.80.10.0-0.1-0.3-0.2-0.3-0.3-0.5-1.1-1.0
Food consumed during 24 hour testing period1.11.61.90.61.31.31.31.31.31.41.41.41.11.1
Glucose0.81.32.40.6-1.5-1.5-1.3-1.3-1.3-1.1-1.2-1.1-0.4-0.6
Heart weight0.50.71.9-1.4-0.5-0.6-0.7-0.8-0.7-0.8-0.9-0.4-1.3-0.9
Delay discount hyperbolic model param4.34.76.10.42.52.52.42.42.32.32.32.41.71.9
Intermittent access intake day 1-15 change0.81.62.4-0.21.61.51.51.51.31.31.41.50.70.9
Intermittent access intake escalation0.71.52.30.01.51.51.41.41.31.31.31.40.60.9
Intermittent access intake escalation 20.80.91.30.50.91.01.01.10.90.91.01.10.80.9
Intermitt. access day 1 inactive lever presses0.31.31.50.81.21.21.21.21.21.11.21.20.91.0
Intermitt. access day 15 inactive lever presses0.61.12.21.50.70.90.91.21.01.11.10.31.51.0
Intermitt. access escalation Index0.30.40.5-0.7-0.6-0.6-0.7-0.7-0.5-0.7-0.7-0.4-0.3-0.4
Intermittent access day 1 total infusions0.71.21.6-0.7-1.2-1.2-1.2-1.1-1.1-1.3-1.2-0.8-0.9-0.8
Intermittent access day 15 total infusions0.10.10.4-0.6-0.1-0.2-0.2-0.1-0.2-0.3-0.30.1-0.4-0.3
Intermittent access terminal intake (last 3 days)0.10.10.2-0.4-0.3-0.3-0.3-0.2-0.3-0.4-0.3-0.1-0.3-0.3
Intermittent access total infusions0.91.11.4-0.7-1.1-1.1-1.1-1.1-1.1-1.2-1.1-1.0-1.0-1.0
Intermittent access day 1 locomotion1.21.62.2-0.5-1.4-1.5-1.5-1.3-1.3-1.5-1.4-1.2-0.9-1.0
Intermittent access day 15 total locomotion0.20.42.3-1.5-0.2-0.3-0.4-0.3-0.3-0.5-0.50.0-0.8-0.5
Intermittent access total locomotion0.91.11.6-0.8-1.1-1.1-1.1-1.1-1.0-1.3-1.2-0.8-1.1-0.9
Intermittent access standard deviation1.02.13.21.21.41.51.51.81.51.61.61.11.41.3
Left kidney weight1.04.920.5-4.52.92.62.01.61.81.61.50.5-1.5-1.1
Right kidney weight0.83.514.3-3.82.52.21.71.21.51.31.30.2-1.4-1.1
Cocaine induced anxiety0.81.21.5-0.5-1.2-1.2-1.2-1.1-1.2-1.0-1.1-1.1-1.0-1.0
Post-drug Anxiety4.34.67.50.3-2.7-2.6-2.5-2.1-2.3-2.1-2.2-2.7-0.9-1.7
Baseline Anxiety1.11.22.50.9-1.5-1.4-1.2-1.0-1.1-1.1-0.9-1.60.3-0.5
Tail length1.24.528.5-5.30.80.4-0.1-0.7-0.4-0.6-0.5-1.1-3.3-2.8
Length with tail1.87.750.6-7.11.91.40.7-0.10.30.10.0-1.0-4.0-3.3
Length without tail1.34.112.6-3.62.82.52.11.61.81.81.70.6-1.1-0.7
Times rat made contact with spout0.30.41.4-1.2-0.2-0.3-0.4-0.4-0.4-0.4-0.4-0.4-0.9-0.8
Lifetime Intake0.60.81.1-0.4-1.0-1.0-1.0-0.8-0.9-1.0-1.0-1.0-0.5-0.7
Liver weight, left4.06.710.8-0.23.33.23.02.82.92.72.82.61.51.8
Liver weight, right0.50.81.8-1.11.31.21.10.91.00.80.90.4-0.10.0
Locomotor activity1.21.98.1-2.8-0.4-0.6-0.8-1.2-0.9-1.1-1.2-0.6-2.2-1.5
Locomotor testing distance0.20.41.2-1.10.90.80.70.40.60.40.40.7-0.20.2
Locomotor testing rearing0.71.31.70.81.21.21.31.11.21.11.11.31.01.2
Locomotion in novel chamber0.20.32.1-1.50.60.50.30.20.40.10.20.4-0.3-0.1
Locomotion in novel chamber post-restriction0.40.62.4-1.6-0.0-0.2-0.4-0.7-0.5-0.8-0.6-0.1-1.3-1.0
Fecal boli incidents, locomotor time 10.50.74.0-2.0-0.1-0.2-0.4-0.6-0.5-0.6-0.5-0.4-1.2-1.0
Change in fecal boli incidents, locomotor task0.20.20.70.80.20.20.30.50.30.40.40.10.80.4
Time >=10cm from walls, locomotor time 11.71.83.00.7-1.7-1.6-1.5-1.4-1.4-1.4-1.3-1.5-0.5-0.9
Bouts of movement, locomotor time 10.10.10.4-0.60.40.30.20.10.1-0.10.00.1-0.6-0.4
Total resting periods, locomotor time 10.10.10.6-0.80.20.1-0.0-0.1-0.1-0.2-0.2-0.1-0.8-0.5
Rest time, locomotor task time 10.10.21.1-1.00.20.10.0-0.1-0.1-0.1-0.1-0.3-0.6-0.6
Distance moved, locomotor task time 10.30.50.90.0-0.8-0.8-0.8-0.9-0.8-0.8-0.7-0.5-0.6-0.4
Vertical activity count, locomotor time 10.10.20.6-0.1-0.4-0.5-0.5-0.5-0.6-0.6-0.5-0.1-0.8-0.5
Time >=10cm from walls, locomotor time 21.01.52.8-0.5-1.3-1.2-1.3-1.1-1.3-1.1-1.2-1.7-1.1-1.5
Bouts of movement, locomotor time 20.10.10.7-0.80.30.20.10.20.10.10.00.1-0.3-0.4
Total resting periods, locomotor time 20.10.10.4-0.70.50.50.40.40.30.30.30.3-0.0-0.1
Rest time, locomotor task time 20.00.00.20.4-0.1-0.1-0.10.1-0.00.1-0.0-0.10.20.1
Distance moved, locomotor task time 20.10.10.2-0.00.40.30.30.20.30.20.30.4-0.10.2
Vertical activity count, locomotor time 20.20.30.8-0.40.90.80.70.40.50.30.50.7-0.5-0.0
Light reinforcement 11.33.14.6-0.4-2.1-2.1-2.0-1.8-2.0-1.9-1.9-1.7-1.2-1.4
Light reinforcement 20.10.20.40.60.20.30.30.50.30.40.30.30.60.5
Bone: marrow area0.81.82.9-0.61.71.61.51.41.41.41.41.50.60.9
Bone: maximum diameter0.10.21.5-1.20.40.30.20.10.10.10.1-0.2-0.6-0.6
Bone: maximum force0.30.53.7-1.90.30.20.0-0.2-0.1-0.2-0.2-0.3-1.1-0.9
Bone: maximum moment0.20.42.8-1.70.40.30.2-0.00.1-0.0-0.0-0.1-0.9-0.6
Mean time between licks in bursts0.10.31.61.3-0.10.00.10.30.20.20.20.50.80.8
Mean num. licks in bursts0.40.60.7-0.4-0.8-0.8-0.8-0.7-0.8-0.8-0.8-0.8-0.6-0.7
Cd content in liver0.80.91.2-0.8-0.9-0.9-0.9-1.1-1.0-1.1-1.1-0.3-1.1-0.8
Co content in liver3.74.35.40.82.32.32.32.22.22.22.12.21.62.0
Cu content in liver0.10.10.20.30.30.30.30.30.30.30.30.50.20.5
Fe content in liver0.70.81.8-1.3-0.6-0.7-0.8-0.9-0.8-0.9-0.9-0.6-1.2-1.0
K content in liver0.10.10.4-0.0-0.4-0.4-0.4-0.3-0.3-0.3-0.3-0.6-0.2-0.4
Mg content in liver0.10.10.1-0.30.30.30.30.30.30.30.3-0.1-0.1-0.0
Mn content in liver0.30.30.60.70.40.50.50.60.50.60.60.50.70.7
Na content in liver0.10.10.6-0.70.00.0-0.1-0.1-0.1-0.1-0.0-0.4-0.4-0.5
Rb content in liver0.40.51.61.3-1.0-0.9-0.7-0.6-0.6-0.6-0.6-0.30.20.2
Se content in liver2.63.05.0-1.3-1.6-1.6-1.7-1.7-1.7-1.7-1.7-2.2-1.7-2.0
Sr content in liver1.31.21.60.31.31.21.21.21.21.21.21.10.80.9
Zn content in liver2.32.64.5-0.72.12.01.91.71.81.71.71.50.50.9
Bone: minimum diameter0.00.00.0-0.00.00.00.00.00.00.00.00.10.00.0
Time in familiar zone, hab. session 11.91.92.51.51.21.21.31.41.41.41.41.11.61.4
Time in novel zone, hab. session 10.80.81.3-1.1-0.7-0.8-0.8-0.9-0.9-0.9-0.9-0.9-1.1-1.1
Total zone transitions, hab. session 10.81.11.80.1-1.3-1.3-1.2-1.2-1.2-1.1-1.2-0.7-0.7-0.6
Total locomotion distance, hab. session 10.81.11.7-0.0-1.3-1.3-1.2-1.2-1.2-1.1-1.2-1.0-0.7-0.8
Locomotion velocity, hab. session 11.21.62.70.1-1.6-1.6-1.5-1.4-1.5-1.3-1.4-1.1-0.8-0.8
Time in familiar zone, hab. session 20.00.00.20.40.00.10.10.20.20.20.2-0.20.30.1
Time in novel zone, hab. session 20.20.20.3-0.2-0.5-0.5-0.5-0.5-0.5-0.6-0.5-0.1-0.4-0.3
Total zone transitions, hab. session 20.10.10.5-0.7-0.2-0.2-0.2-0.3-0.3-0.3-0.3-0.1-0.5-0.4
Total locomotion distance, hab. session 20.20.20.3-0.2-0.5-0.5-0.5-0.5-0.5-0.4-0.5-0.3-0.4-0.3
Locomotion velocity, hab. session 20.10.20.2-0.2-0.5-0.5-0.5-0.5-0.5-0.4-0.5-0.2-0.4-0.3
Novel to familiar place preference ratio0.10.10.2-0.3-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.2-0.3-0.3
Novelty place preference0.10.10.2-0.1-0.5-0.5-0.4-0.4-0.4-0.5-0.4-0.2-0.3-0.2
Time in novel zone, NPP test0.10.10.2-0.2-0.4-0.4-0.4-0.4-0.4-0.5-0.4-0.3-0.3-0.3
Total zone transitions, NPP test0.20.30.5-0.6-0.5-0.5-0.6-0.6-0.6-0.6-0.6-0.4-0.7-0.6
Total locomotion distance, NPP test1.52.12.4-0.9-1.5-1.5-1.5-1.5-1.5-1.5-1.5-1.3-1.4-1.3
Locomotion velocity, NPP test1.42.02.3-1.1-1.4-1.5-1.5-1.5-1.5-1.5-1.5-1.2-1.5-1.3
Intraocular pressure0.30.40.9-0.60.90.80.70.60.60.50.50.6-0.30.0
Delta distance traveled before/after self-admin0.70.71.6-0.10.90.90.90.90.80.80.91.30.50.7
Delta ambulatory time before/after self-admin0.50.61.30.40.70.70.80.90.70.80.81.10.80.9
Parametrial fat weight0.00.10.50.4-0.1-0.00.00.20.10.10.1-0.70.3-0.1
Pavlov. Cond. lever latency0.70.91.7-0.91.31.21.11.01.00.91.00.70.20.2
Pavlov. Cond. magazine entry latency0.50.71.2-1.1-0.6-0.6-0.7-0.8-0.8-0.8-0.8-0.7-1.0-0.9
Pavlov. Cond. change in total contacts2.12.23.0-0.2-1.7-1.7-1.6-1.6-1.6-1.6-1.6-1.7-1.1-1.3
Pavlov. Cond. index score0.60.81.0-0.3-1.0-1.0-1.0-1.0-1.0-0.9-0.9-0.9-0.7-0.8
Pavlov. Cond. latency score0.91.11.6-0.2-1.3-1.2-1.2-1.2-1.2-1.1-1.2-1.1-0.8-0.9
Pavlov. Cond. lever contacts0.81.01.80.8-1.3-1.3-1.1-1.0-1.1-1.0-1.0-0.9-0.3-0.4
Pavlov. Cond. magazine entry number0.70.91.41.20.80.80.91.00.91.01.00.81.21.1
Pavlov. Cond. intertrial magazine entries0.20.31.11.10.10.20.30.30.30.40.30.60.70.8
Pavlov. Cond. lever-magazine prob. diff.0.50.60.8-0.2-0.9-0.9-0.9-0.8-0.9-0.8-0.8-0.9-0.6-0.7
Pavlov. Cond. response bias0.60.81.0-0.8-0.8-0.9-0.9-0.9-0.9-0.9-0.9-0.8-1.0-0.9
Pavlov. Cond. lever latency1.52.02.90.91.51.51.51.71.51.51.51.21.31.3
Pavlov. Cond. magazine entry latency3.13.75.3-0.3-2.3-2.3-2.2-2.2-2.1-2.1-2.1-1.9-1.4-1.5
Pavlov. Cond. change in total contacts0.91.42.2-0.8-1.2-1.3-1.3-1.5-1.3-1.3-1.3-0.8-1.2-1.0
Pavlov. Cond. index score2.12.84.1-0.6-1.9-1.9-1.9-2.0-1.8-1.8-1.8-1.4-1.4-1.3
Pavlov. Cond. latency score2.12.73.8-0.6-1.9-1.9-1.8-2.0-1.8-1.8-1.8-1.4-1.3-1.3
Pavlov. Cond. lever contacts1.92.63.7-0.9-1.7-1.8-1.7-1.9-1.8-1.7-1.7-1.4-1.5-1.5
Pavlov. Cond. magazine entry number2.02.53.70.21.91.91.81.81.81.71.71.31.11.1
Pavlov. Cond. intertrial magazine entries0.10.20.6-0.80.60.60.50.40.40.30.30.5-0.10.0
Pavlov. Cond. lever-magazine prob. diff.2.43.24.5-0.7-2.0-2.0-2.0-2.1-2.0-1.9-1.9-1.5-1.5-1.4
Pavlov. Cond. response bias2.94.05.7-0.9-2.2-2.2-2.2-2.4-2.2-2.2-2.2-1.7-1.8-1.7
Time in closed arm before self-admin0.40.51.0-1.01.00.90.80.50.60.60.60.9-0.40.1
Time in closed arm after self-admin0.40.42.3-1.20.30.1-0.1-0.4-0.1-0.4-0.30.1-1.5-0.7
Time in open arm before self-admin1.11.21.6-1.1-1.0-1.0-1.0-1.2-1.0-1.3-1.1-1.0-1.2-1.0
Time in open arm after self-admin0.20.20.70.8-0.6-0.5-0.4-0.1-0.4-0.1-0.3-0.30.80.2
Bone: periosteal estimation0.20.43.0-1.70.50.30.20.00.10.00.0-0.1-0.9-0.7
Bone: periosteal perimeter0.81.42.9-1.7-0.8-0.9-1.0-1.1-1.1-1.1-1.1-0.9-1.5-1.4
Bone: post-yield work0.00.10.2-0.50.30.30.30.20.20.20.20.3-0.10.0
Progressive ratio test 1 active lever presses0.30.42.3-1.5-0.1-0.2-0.3-0.3-0.3-0.5-0.4-0.4-0.8-0.8
Progressive ratio test 1 breakpoint0.30.42.2-1.5-0.1-0.2-0.3-0.3-0.3-0.5-0.4-0.5-0.8-0.8
Progressive ratio test 1 inactive lever presses0.71.01.6-0.51.31.21.11.21.11.00.91.10.40.6
Progressive ratio test 2 active lever presses0.20.31.6-1.30.20.1-0.0-0.3-0.1-0.3-0.20.1-0.9-0.5
Progressive ratio test 2 breakpoint0.20.31.5-1.20.20.1-0.0-0.3-0.1-0.4-0.20.1-0.9-0.5
Progressive ratio test 2 inactive lever presses1.01.63.1-1.01.81.61.41.21.41.11.31.5-0.20.6
Incentive Sensitization - Responses0.00.00.10.20.10.10.1-0.00.10.00.10.4-0.10.2
Incentive Sensitization - Breakpoint0.00.00.20.20.10.10.1-0.10.10.00.10.4-0.10.2
Sum of active levers in priming session hrs 5-60.10.10.50.5-0.3-0.3-0.3-0.1-0.3-0.1-0.2-0.70.2-0.3
Progressive ratio0.10.10.80.9-0.1-0.1-0.0-0.00.10.00.1-0.10.60.4
Food seeking constrained by brief footshock4.25.27.82.41.81.92.02.72.12.52.12.12.82.4
Seeking ratio, punishment vs. effort0.50.71.2-0.11.00.90.91.10.71.00.80.90.40.5
Retroperitoneal fat weight0.31.23.00.1-1.3-1.2-1.2-1.0-1.1-1.0-1.0-1.7-0.3-1.0
Reaction time number correct0.81.62.7-0.41.61.51.41.31.31.31.21.60.71.0
Reaction time mean minus median3.89.510.6-2.4-3.0-3.1-3.2-3.2-3.2-3.2-3.3-3.0-3.2-3.1
Reaction time mean minus median AUC1.53.84.8-1.4-2.0-2.0-2.0-2.2-2.1-2.1-2.1-1.6-2.0-1.7
Reaction time num false alarms1.52.13.1-1.1-1.5-1.5-1.5-1.8-1.6-1.6-1.5-1.1-1.3-1.3
Reaction time num false alarms AUC0.81.21.9-0.9-1.1-1.1-1.2-1.4-1.2-1.2-1.2-0.8-1.1-1.0
Reaction time trials correct on left0.81.62.7-0.41.61.51.41.31.31.31.21.60.71.0
Reaction time trials on left0.71.42.4-0.51.51.41.31.21.21.21.11.60.61.0
Reaction time mean3.25.17.8-0.1-2.8-2.7-2.6-2.3-2.5-2.4-2.5-2.4-1.4-1.7
Reaction time mean AUC2.94.77.3-0.0-2.7-2.6-2.5-2.3-2.4-2.3-2.4-2.2-1.3-1.6
Median of all reaction times1.92.75.00.9-2.2-2.1-1.9-1.6-1.8-1.7-1.7-1.8-0.4-0.9
Reaction time omissions1.52.22.9-0.3-1.7-1.7-1.7-1.6-1.6-1.7-1.6-1.5-1.3-1.3
Reaction time false alarm rate2.12.93.7-0.8-1.8-1.8-1.8-1.9-1.8-1.9-1.8-1.6-1.5-1.6
Reaction time premature initiation rate1.21.72.0-1.1-1.2-1.3-1.3-1.3-1.3-1.4-1.4-1.3-1.3-1.3
Reaction time premature initiations0.30.51.4-1.2-0.4-0.5-0.5-0.6-0.6-0.6-0.7-0.4-0.8-0.6
Std. dev. reaction times3.76.88.1-1.3-2.8-2.8-2.8-2.7-2.8-2.8-2.8-2.7-2.3-2.4
Reaction time trials completed0.71.42.4-0.51.51.41.31.21.21.21.11.60.61.0
Reaction time trials AUC0.71.32.5-0.41.41.31.31.11.21.21.11.60.61.0
Run reversals in cocaine runway, females0.30.31.61.30.10.20.30.50.30.40.30.30.90.7
Run reversals in cocaine runway, males0.50.51.00.40.60.50.51.00.51.00.41.00.30.6
Latency to leave start box in cocaine runway0.20.20.4-0.7-0.4-0.4-0.4-0.5-0.4-0.3-0.3-0.60.0-0.3
Latency to leave start box in cocaine runway, F0.00.00.1-0.10.20.20.20.20.20.30.3-0.20.2-0.0
Latency to leave start box in cocaine runway, M0.30.30.9-0.9-0.5-0.5-0.5-0.6-0.5-0.6-0.5-0.3-0.1-0.3
Std. dev. time between licks in bursts0.20.30.7-0.9-0.3-0.3-0.4-0.5-0.4-0.5-0.5-0.2-0.7-0.5
Total sessions with >9 infusions0.10.10.30.4-0.1-0.00.00.20.10.10.1-0.30.60.2
Short access day 1 total inactive lever presses1.11.42.30.51.21.31.21.51.31.41.30.91.01.0
Short access day 10 total inactive lever presses2.15.26.91.12.62.62.62.62.52.52.61.81.71.8
Short access day 1 total infusions0.30.41.31.10.10.20.30.60.40.50.40.11.10.7
Short access day 10 total infusions0.00.00.20.4-0.2-0.2-0.10.0-0.1-0.1-0.1-0.10.30.2
Short access total infusions0.20.20.50.6-0.6-0.5-0.4-0.1-0.3-0.2-0.3-0.70.60.0
Short access day 1 locomotion1.62.02.6-1.1-1.5-1.6-1.6-1.3-1.5-1.6-1.6-1.5-1.0-1.3
Short access day 10 total locomotion0.51.01.80.51.01.01.01.31.11.00.90.81.10.9
Short access total locomotion0.40.50.90.2-0.9-0.9-0.8-0.4-0.7-0.8-0.8-0.9-0.1-0.4
One hour access (0.3 mA shock)0.60.72.3-0.81.11.00.90.80.70.50.61.5-0.10.4
Compulsive drug intake0.40.42.31.5-0.00.00.20.30.20.20.30.61.00.9
One hour access (shock baseline)0.60.93.9-2.0-0.2-0.3-0.5-0.7-0.6-0.7-0.7-0.3-1.5-1.1
Social response proportion3.43.99.6-3.1-1.1-1.3-1.5-1.6-1.6-1.7-1.7-1.9-2.6-2.5
Social responses0.81.15.4-2.3-0.2-0.4-0.5-0.7-0.6-0.8-0.8-0.5-1.5-1.2
Social time1.31.72.80.1-1.7-1.6-1.5-1.5-1.5-1.5-1.5-1.0-0.7-0.7
Soleus weight0.20.62.6-1.61.00.90.70.50.60.50.50.5-0.5-0.2
Bone: stiffness0.91.53.2-1.8-0.8-0.9-1.0-1.2-1.1-1.2-1.2-0.9-1.6-1.4
Tibialis anterior weight1.13.720.6-4.50.3-0.0-0.5-0.8-0.7-0.8-0.8-1.4-2.8-2.7
Time to tail flick, vehicle, before self-admin2.52.64.1-0.0-1.9-1.8-1.8-1.6-1.7-1.6-1.7-2.0-0.8-1.4
Time to tail flick, vehicle, after self-admin0.40.51.0-0.6-0.7-0.7-0.7-0.7-0.7-0.7-0.8-0.6-1.0-0.7
Time to tail flick, test, before self-admin0.20.20.8-0.90.60.60.50.40.30.40.40.4-0.4-0.1
Time to tail flick, test, after self-admin0.40.40.9-0.6-0.8-0.7-0.7-0.4-0.6-0.4-0.6-0.9-0.1-0.6
Delta time to tail flick, vehicle, before/after SA0.10.10.60.00.40.30.40.30.30.30.30.8-0.10.4
Delta time to tail flick, test, before/after SA0.10.10.50.7-0.3-0.2-0.10.0-0.00.0-0.0-0.10.70.4
Tibia length0.30.94.4-2.11.21.00.80.60.60.60.6-0.4-0.8-0.9
Ambulatory time before self-admin0.71.01.5-0.2-1.0-1.1-1.1-1.2-1.0-1.2-1.1-0.9-1.1-0.8
Ambulatory time after self-admin0.20.20.40.2-0.5-0.5-0.5-0.6-0.5-0.7-0.5-0.0-0.6-0.2
Bone: tissue strength2.82.83.21.21.71.71.81.81.81.81.81.61.71.7
Total heroin consumption2.32.74.20.8-2.1-2.0-1.9-1.9-1.8-1.9-1.8-1.3-1.0-0.9
Bone: trabecular number0.71.12.2-1.21.51.41.21.01.11.01.00.70.00.1
Bone: trabecular spacing0.30.43.01.7-0.5-0.4-0.2-0.0-0.1-0.0-0.00.10.80.7
Bone: trabecular thickness0.40.52.1-1.50.90.80.70.50.50.50.50.2-0.4-0.4
Bone: trabecular tissue density6.910.111.1-2.2-3.2-3.3-3.3-3.3-3.3-3.3-3.3-3.3-3.1-3.3
Water consumed over 24 hours0.81.12.1-0.91.41.31.21.01.11.11.11.00.20.3
Number of responses in last shaping day0.00.10.20.5-0.3-0.3-0.20.0-0.1-0.2-0.2-0.30.10.0