Rexo1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	isoform ratio	XR_005486605.2	0.04	0.03	5.4e-04	0.02	0.02	0.03	0.02	4.5e-03	4.3e-03	1.6e-03	8.1e-03
2	Brain	isoform ratio	XM_063263421.1	0.05	0.04	1.9e-05	0.04	0.04	0.03	0.04	3.1e-04	2.0e-04	1.7e-03	3.0e-04
3	PL	mRNA stability	Rexo1	0.03	0.02	3.5e-04	0.03	0.03	0.03	0.03	4.9e-04	1.4e-04	2.9e-04	3.3e-04
4	NAcc	gene expression	Rexo1	0.02	0.01	2.8e-03	0.01	0.01	0.01	0	2.5e-02	2.3e-02	1.6e-02	5.7e-02
5	Brain	mRNA stability	Rexo1	0.04	0.03	6.6e-04	0.03	0.03	0.03	0.03	3.8e-04	4.3e-04	8.2e-04	4.2e-04
6	PL	isoform ratio	XM_063263421.1	0.02	0.01	5.3e-03	0.01	0.01	0	0.01	8.3e-03	2.4e-02	1.0e-01	4.9e-02
7	Brain	gene expression	Rexo1	0.09	0.07	9.3e-08	0.08	0.06	0.06	0.07	8.8e-08	1.4e-06	5.3e-06	2.3e-07
8	Liver	isoform ratio	XM_063263421.1	0.02	0.02	2.2e-03	0.02	0.02	0.01	0.01	4.4e-03	5.2e-03	9.1e-03	1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.2	0.3	0.5	-0.5	0.1	0.1	-0.6	-0.7	-0.7	0.7	-0.7
Area under the delay curve	1.8	2.7	3.4	1.4	1.7	1.6	1.8	-1.7	-1.6	1.6	-1.7
BMI with tail	6.4	22.3	24.5	4.9	4.9	4.9	4.5	-4.6	-4.7	4.7	-4.6
BMI without tail	1.2	6.3	8.2	2.9	2.7	2.6	2.7	-2.3	-2.3	2.3	-2.2
Body weight	0.9	4.0	4.4	2.1	2.1	2.1	1.8	-2.0	-2.0	2.0	-1.9
Weight adjusted by age	0.1	0.4	1.0	1.0	0.8	0.7	0.7	-0.4	-0.5	0.5	-0.4
Bone surface	0.3	0.6	1.9	-1.4	-0.7	-0.6	-1.4	-0.3	-0.3	0.3	-0.3
Bone volume	0.3	0.5	1.7	-1.3	-0.6	-0.5	-1.2	-0.3	-0.3	0.3	-0.3
Breakpoint value in progressive ratio session	2.5	4.4	5.9	-2.0	-2.2	-2.2	-1.1	2.3	2.4	-2.3	2.1
Number of licking bursts	0.0	0.1	0.2	0.5	0.2	0.2	0.4	0.2	0.2	-0.2	0.2
Context. condit. distance diff. score	0.4	0.5	0.7	0.8	0.7	0.7	0.9	-0.6	-0.6	0.6	-0.6
Locomotion velocity, session 1	0.5	0.6	1.6	-1.1	-0.8	-0.8	-1.3	0.4	0.5	-0.5	0.4
Locomotion distance, session 1	0.4	0.5	2.6	-1.0	-0.6	-0.5	-1.6	-0.1	-0.1	0.1	-0.1
Locomotion velocity, session 2	3.8	4.5	8.6	-2.7	-2.3	-2.2	-2.9	1.5	1.6	-1.6	1.5
Locomotion distance, session 2	2.0	2.9	7.7	-2.2	-1.8	-1.6	-2.8	1.0	1.0	-1.0	1.0
Locomotion velocity, session 3	6.0	6.9	7.3	-2.6	-2.7	-2.7	-2.2	2.6	2.7	-2.7	2.6
Locomotion distance, session 3	0.0	0.0	0.1	0.2	0.1	0.0	0.3	0.0	0.1	-0.1	0.0
Stereotopy head waving bouts, day 3	4.9	5.9	8.0	-2.8	-2.6	-2.5	-2.6	2.2	2.2	-2.2	2.2
Stereotopy head waving duration, day 3	5.7	7.1	9.2	-3.0	-2.8	-2.8	-2.6	2.5	2.5	-2.5	2.5
Locomotion velocity, session 7	0.4	0.4	0.6	-0.5	-0.6	-0.7	-0.3	0.8	0.8	-0.8	0.8
Locomotion distance, session 7	0.2	0.3	1.0	0.9	0.6	0.5	1.0	-0.1	-0.1	0.1	-0.1
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	-0.4	-0.1	0.0	-0.4	-0.4	-0.4	0.4	-0.4
Stereotopy head waving duration, day 7	0.3	0.4	1.1	-1.0	-0.7	-0.6	-1.1	0.2	0.2	-0.2	0.2
Locomotion velocity, session 8	0.6	0.7	2.4	-1.2	-0.9	-0.8	-1.5	0.3	0.3	-0.3	0.3
Locomotion distance, session 8	0.2	0.2	0.8	-0.6	-0.5	-0.4	-0.9	0.2	0.2	-0.2	0.2
Degree of sensitization distance	0.4	0.5	0.6	0.7	0.7	0.7	0.6	-0.7	-0.7	0.7	-0.7
Degree of sensitization stereotypy	1.7	1.9	2.5	1.1	1.3	1.3	0.9	-1.6	-1.5	1.5	-1.6
Conditioned locomotion	1.3	1.5	3.0	1.6	1.4	1.3	1.7	-0.9	-1.0	1.0	-0.9
Cocaine response after cond. corrected	4.3	6.4	9.9	3.0	2.8	2.7	3.1	-2.1	-2.1	2.1	-2.1
Cocaine response after cond. not corrected	4.7	6.8	10.9	3.1	2.8	2.7	3.3	-2.2	-2.2	2.2	-2.2
Cocaine response before conditioning	0.4	0.5	0.7	-0.8	-0.8	-0.8	-0.3	0.7	0.6	-0.6	0.7
Saline control response	0.2	0.3	1.2	0.5	0.4	0.4	1.1	-0.2	-0.2	0.2	-0.2
Bone: connectivity density	0.3	0.5	0.9	0.1	0.5	0.5	-0.2	-1.0	-1.0	1.0	-1.0
Bone: cortical apparent density	0.8	1.2	1.4	1.1	1.1	1.1	1.2	-1.1	-1.1	1.1	-1.1
Bone: cortical area	0.4	0.7	1.0	0.4	0.7	0.7	0.5	-1.0	-1.0	1.0	-1.0
Bone: cortical porosity	0.2	0.2	0.8	-0.6	-0.4	-0.4	-0.9	0.2	0.2	-0.2	0.2
Bone: cortical porosity	0.1	0.1	0.5	-0.4	-0.2	-0.1	-0.7	-0.2	-0.2	0.2	-0.2
Bone: cortical thickness	1.0	1.7	2.1	1.0	1.3	1.3	1.1	-1.5	-1.5	1.5	-1.5
Bone: cortical thickness	0.1	0.1	0.2	0.2	0.0	-0.1	0.4	0.4	0.4	-0.4	0.4
Bone: cortical tissue density	0.5	0.8	1.0	0.9	0.9	0.9	1.0	-0.9	-0.9	0.9	-0.9
Condit. Reinf. active minus inactive responses	4.2	4.7	5.2	-2.3	-2.3	-2.3	-2.0	2.1	2.2	-2.2	2.1
Condit. Reinf. active-inactive response ratio	2.1	2.2	2.8	-1.3	-1.5	-1.5	-1.0	1.6	1.7	-1.7	1.6
Condit. Reinf. active responses	3.7	4.7	6.6	-2.6	-2.3	-2.3	-2.5	1.9	1.9	-1.9	1.9
Condit. Reinf. inactive responses	0.9	1.2	3.5	-1.4	-1.2	-1.1	-1.9	0.6	0.6	-0.6	0.6
Incentive salience index mean	2.2	2.8	4.0	-2.0	-1.8	-1.8	-2.0	1.4	1.5	-1.5	1.4
Condit. Reinf. lever presses	0.2	0.3	1.7	-0.8	-0.4	-0.3	-1.3	-0.3	-0.2	0.2	-0.3
Condit. Reinf. active minus inactive responses	1.9	3.0	3.9	-1.4	-1.6	-1.7	-1.0	1.9	2.0	-2.0	1.9
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.4	0.0	-0.2	-0.2	-0.1	0.6	0.6	-0.6	0.6
Condit. Reinf. active responses	2.1	3.0	3.7	-1.7	-1.7	-1.8	-0.9	1.9	1.9	-1.9	1.9
Condit. Reinf. inactive responses	0.8	1.2	1.6	-1.2	-1.1	-1.2	-0.2	1.2	1.2	-1.2	1.2
Condit. Reinf. lever presses	1.7	2.5	3.2	-1.3	-1.5	-1.6	-0.7	1.8	1.8	-1.8	1.8
Condit. Reinf. lever reinforcers received	1.6	2.2	2.9	-1.3	-1.4	-1.5	-0.4	1.7	1.7	-1.7	1.7
Conditioned reinforcement - actives	0.5	1.8	2.5	-0.7	-1.1	-1.2	-1.6	1.6	1.5	-1.5	1.5
Conditioned reinforcement - inactives	0.0	0.0	0.2	0.4	0.2	0.2	-0.1	0.1	0.1	-0.1	-0.1
Conditioned locomotion	7.1	10.6	11.6	-3.1	-3.2	-3.3	-3.2	3.3	3.4	-3.4	3.1
Patch foraging indifference point 0 sec	0.1	0.3	0.4	0.4	0.5	0.5	0.5	-0.5	-0.6	0.6	-0.5
Patch foraging indifference point AUC	0.6	1.4	1.7	-1.1	-1.1	-1.1	-1.2	1.2	1.3	-1.3	1.2
Delay disc. indifference point, 0s delay	7.2	8.1	10.8	2.3	2.7	2.8	1.4	-3.2	-3.2	3.3	-3.3
Delay disc. indifference point, 16s delay	0.2	0.3	0.7	0.3	0.4	0.4	0.8	-0.6	-0.5	0.4	-0.5
Delay disc. indifference point, 2s delay	6.5	7.3	8.2	2.5	2.7	2.7	2.5	-2.8	-2.8	2.9	-2.8
Delay disc. indifference point, 24s delay	0.5	0.7	1.2	1.0	0.9	0.9	1.1	-0.9	-0.7	0.6	-0.7
Delay disc. indifference point, 4s delay	1.6	1.7	2.3	0.9	1.2	1.2	1.3	-1.5	-1.4	1.3	-1.4
Delay disc. indifference point, 8s delay	0.8	1.4	1.9	1.2	1.3	1.3	1.4	-1.1	-1.0	1.0	-1.1
Indifference point function ln k	0.1	0.3	0.8	0.7	0.6	0.5	0.9	-0.4	-0.4	0.4	-0.4
Indifference point function log k	0.1	0.3	0.8	0.7	0.6	0.5	0.9	-0.4	-0.4	0.4	-0.4
Patch foraging total patch changes 0 sec	0.1	0.2	0.3	0.4	0.4	0.4	0.4	-0.5	-0.5	0.5	-0.5
Patch foraging total patch changes 12 sec	0.3	0.4	0.7	0.9	0.7	0.7	0.5	-0.5	-0.5	0.5	-0.5
Patch foraging total patch changes 18 sec	0.5	1.2	1.4	-1.2	-1.1	-1.1	-1.0	1.1	1.0	-1.0	1.1
Patch foraging total patch changes 24 sec	0.0	0.1	0.2	-0.4	-0.4	-0.3	0.0	0.3	0.2	-0.2	0.3
Patch foraging total patch changes 6 sec	0.2	0.4	1.0	-0.8	-0.6	-0.6	-1.0	0.5	0.5	-0.5	0.5
Patch foraging time to switch 0 sec	0.5	2.1	3.5	0.8	1.1	1.3	0.2	-1.9	-1.8	1.8	-1.7
Patch foraging water rate 0 sec	0.1	0.3	0.5	0.7	0.2	0.1	0.7	0.6	0.5	-0.5	0.5
Patch foraging water rate 12 sec	0.4	1.6	3.9	1.8	1.4	1.3	2.0	-0.7	-0.8	0.8	-0.8
Patch foraging water rate 18 sec	0.3	0.7	1.6	0.7	0.1	-0.1	1.3	1.1	0.9	-0.9	0.9
Patch foraging water rate 24 sec	0.5	0.8	2.3	1.5	0.9	0.8	1.5	0.1	0.0	-0.0	-0.0
Patch foraging water rate 6 sec	0.5	0.7	1.3	0.1	-0.4	-0.5	0.6	1.1	1.1	-1.1	1.1
Seeking ratio, delayed vs. immediate footshock	3.2	4.6	5.7	-2.4	-2.3	-2.3	-1.4	2.1	2.2	-2.2	2.1
Distance traveled before self-admin	0.1	0.1	0.4	0.3	0.3	0.3	0.3	-0.4	-0.3	0.3	-0.6
Distance traveled after self-admin	0.0	0.0	0.1	-0.1	-0.1	-0.2	0.1	0.1	0.2	-0.3	0.1
Extensor digitorum longus weight	4.3	17.0	20.5	4.5	4.4	4.4	4.3	-3.9	-3.8	3.8	-3.9
Bone: elastic displacement	0.2	0.2	0.4	-0.5	-0.4	-0.5	-0.6	0.4	0.4	-0.4	0.4
Bone: elastic work	0.3	0.4	0.5	0.5	0.7	0.6	0.6	-0.7	-0.7	0.7	-0.7
Bone: endosteal estimation	0.2	0.4	0.5	0.5	0.6	0.6	0.5	-0.7	-0.7	0.7	-0.7
Bone: endosteal perimeter	0.2	0.5	0.8	-0.9	-0.8	-0.8	-0.9	0.5	0.5	-0.5	0.5
Epididymis fat weight	0.0	0.1	0.5	0.4	0.2	0.2	0.7	0.3	0.2	-0.2	0.1
Delta time in closed arm before/after self-admin	0.8	0.8	2.6	1.4	0.9	0.8	1.6	-0.1	-0.1	0.1	-0.2
Delta time in open arm before/after self-admin	0.5	0.6	0.8	0.7	0.8	0.8	0.6	-0.9	-0.8	0.8	-0.9
Diff in mean of infusions in LGA sessions	1.1	1.9	2.6	-1.5	-1.5	-1.4	-1.0	1.3	1.6	-1.4	1.2
Delay discount exponential model param	1.7	2.3	3.2	-1.3	-1.5	-1.5	-1.8	1.6	1.4	-1.4	1.5
Extinction: sum of active levers before priming	0.8	1.2	1.8	-0.8	-1.0	-1.0	-0.4	1.4	1.3	-1.3	1.1
Active lever presses in extinction session 6	2.7	2.8	3.2	-1.6	-1.6	-1.7	-1.7	1.7	1.8	-1.8	1.5
Bone: final force	1.4	2.2	2.7	1.1	1.5	1.4	1.3	-1.6	-1.6	1.6	-1.6
Bone: final moment	1.1	1.8	2.2	1.0	1.3	1.3	1.1	-1.5	-1.5	1.5	-1.5
Food consumed during 24 hour testing period	0.4	0.8	1.5	1.0	0.9	0.9	1.2	-0.8	-0.8	0.8	-0.8
Glucose	2.6	4.1	4.7	2.2	2.1	2.1	2.0	-2.0	-1.9	1.9	-2.0
Heart weight	0.5	0.8	1.3	-0.5	-0.7	-0.8	-0.0	1.1	1.1	-1.1	1.1
Delay discount hyperbolic model param	3.0	3.8	4.8	-1.8	-2.0	-1.9	-2.2	2.0	1.9	-1.9	2.0
Intermittent access intake day 1-15 change	1.3	7.1	8.5	-2.3	-2.5	-2.6	-2.1	2.9	2.9	-2.9	2.9
Intermittent access intake escalation	1.1	6.2	7.4	-2.1	-2.4	-2.5	-2.0	2.7	2.7	-2.7	2.7
Intermittent access intake escalation 2	3.2	5.4	6.5	-2.1	-2.3	-2.3	-1.7	2.5	2.5	-2.5	2.5
Intermitt. access day 1 inactive lever presses	0.0	0.5	1.2	0.2	-0.2	-0.3	0.0	0.8	1.1	-1.1	0.6
Intermitt. access day 15 inactive lever presses	0.1	0.5	1.0	-0.7	-0.7	-0.7	-1.0	0.6	0.8	-0.8	0.6
Intermitt. access escalation Index	0.3	0.9	1.4	0.6	0.8	0.9	0.1	-1.2	-1.2	1.2	-1.1
Intermittent access day 1 total infusions	0.1	0.2	0.5	0.0	-0.2	-0.3	-0.2	0.6	0.7	-0.7	0.4
Intermittent access day 15 total infusions	1.6	4.0	5.1	-1.6	-1.8	-1.9	-1.7	2.2	2.3	-2.3	2.0
Intermittent access terminal intake (last 3 days)	1.5	2.7	3.5	-1.2	-1.5	-1.6	-1.5	1.9	1.9	-1.9	1.6
Intermittent access total infusions	1.1	1.3	1.8	-0.7	-1.0	-1.1	-1.3	1.4	1.3	-1.3	1.1
Intermittent access day 1 locomotion	1.0	1.8	2.8	-0.9	-1.2	-1.3	-0.8	1.7	1.6	-1.6	1.4
Intermittent access day 15 total locomotion	1.6	6.1	7.3	-2.1	-2.3	-2.4	-2.5	2.6	2.7	-2.7	2.4
Intermittent access total locomotion	2.6	3.1	4.0	-1.4	-1.6	-1.7	-1.5	2.0	2.0	-2.0	1.8
Intermittent access standard deviation	1.6	8.3	9.2	-2.7	-2.8	-2.9	-2.9	3.0	3.0	-3.0	2.8
Left kidney weight	0.0	0.1	0.5	0.5	0.3	0.2	0.7	0.2	0.2	-0.2	0.2
Right kidney weight	0.3	1.9	2.8	-0.9	-1.2	-1.3	-0.4	1.7	1.7	-1.7	1.6
Cocaine induced anxiety	0.6	1.6	2.9	-1.7	-1.4	-1.3	-1.6	0.9	0.9	-0.9	1.0
Post-drug Anxiety	1.0	1.1	2.8	-1.7	-1.3	-1.2	-1.0	0.7	0.7	-0.7	0.7
Baseline Anxiety	0.0	0.1	0.3	-0.2	-0.2	-0.2	0.5	0.3	0.3	-0.3	0.1
Tail length	2.4	13.0	14.6	-3.4	-3.6	-3.7	-2.9	3.8	3.8	-3.8	3.8
Length with tail	1.9	8.3	9.1	-2.8	-2.9	-2.9	-2.4	3.0	3.0	-3.0	3.0
Length without tail	0.0	0.0	0.0	0.1	0.1	0.1	0.2	-0.0	-0.1	0.1	-0.1
Times rat made contact with spout	0.2	0.3	0.9	0.7	0.5	0.5	0.9	-0.2	-0.2	0.2	-0.2
Lifetime Intake	0.6	0.7	1.2	-0.5	-0.7	-0.7	-1.0	1.1	1.0	-1.0	0.8
Liver weight, left	1.0	1.7	1.9	1.3	1.3	1.3	1.4	-1.2	-1.3	1.3	-1.3
Liver weight, right	0.6	1.1	1.7	1.3	1.2	1.1	1.3	-0.8	-0.8	0.8	-0.9
Locomotor activity	3.1	4.8	7.0	-2.6	-2.4	-2.4	-2.0	2.0	2.0	-2.0	2.0
Locomotor testing distance	1.2	3.0	4.7	-2.2	-1.9	-1.9	-1.4	1.6	1.6	-1.6	1.6
Locomotor testing rearing	0.0	0.1	0.5	-0.1	-0.1	-0.2	0.7	0.3	0.3	-0.3	0.3
Locomotion in novel chamber	1.2	1.6	2.2	-1.1	-1.2	-1.2	-1.0	1.3	1.5	-1.5	1.3
Locomotion in novel chamber post-restriction	0.5	1.5	1.9	-1.1	-1.2	-1.3	0.0	1.3	1.3	-1.3	1.4
Fecal boli incidents, locomotor time 1	0.6	1.6	2.0	1.3	1.4	1.4	1.2	-1.2	-1.2	1.3	-1.3
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	-0.3	-0.4	-0.6	-0.5	0.5	0.5	-0.4	0.4
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.5	0.3	0.5	0.5	-0.4	-0.7	-0.7	0.6	-0.6
Bouts of movement, locomotor time 1	0.3	0.4	0.6	-0.4	-0.6	-0.6	-0.8	0.7	0.7	-0.7	0.7
Total resting periods, locomotor time 1	0.4	0.5	0.5	-0.5	-0.7	-0.7	-0.7	0.7	0.7	-0.7	0.7
Rest time, locomotor task time 1	0.2	0.3	0.7	-0.5	-0.6	-0.6	-0.9	0.5	0.5	-0.4	0.4
Distance moved, locomotor task time 1	0.3	0.7	1.2	0.6	0.8	0.8	0.1	-1.1	-1.1	1.0	-1.0
Vertical activity count, locomotor time 1	0.0	0.3	0.6	0.7	0.6	0.5	0.8	-0.3	-0.3	0.3	-0.3
Time >=10cm from walls, locomotor time 2	0.5	1.3	2.0	1.4	1.3	1.2	1.4	-0.9	-1.0	0.9	-0.9
Bouts of movement, locomotor time 2	0.2	0.6	2.5	-1.0	-0.7	-0.7	-1.6	0.3	0.3	-0.3	0.3
Total resting periods, locomotor time 2	0.1	0.6	2.4	-1.0	-0.7	-0.6	-1.5	0.2	0.2	-0.3	0.3
Rest time, locomotor task time 2	0.4	0.7	1.1	-1.1	-0.9	-0.9	-1.1	0.6	0.6	-0.7	0.7
Distance moved, locomotor task time 2	0.5	0.6	1.0	1.0	0.9	0.9	0.6	-0.7	-0.7	0.7	-0.7
Vertical activity count, locomotor time 2	0.2	0.6	1.3	1.1	0.9	0.9	0.9	-0.5	-0.4	0.5	-0.5
Light reinforcement 1	2.2	10.2	12.6	-3.5	-3.5	-3.4	-3.1	2.9	3.0	-3.0	3.1
Light reinforcement 2	1.2	2.7	3.3	-1.8	-1.8	-1.8	-1.6	1.5	1.5	-1.5	1.5
Bone: marrow area	0.2	0.4	0.5	0.5	0.6	0.6	0.5	-0.7	-0.7	0.7	-0.7
Bone: maximum diameter	0.7	1.5	2.4	-1.6	-1.3	-1.3	-1.4	1.0	1.0	-1.0	1.0
Bone: maximum force	1.2	2.4	2.7	1.3	1.5	1.5	1.4	-1.6	-1.6	1.6	-1.6
Bone: maximum moment	1.1	2.0	2.3	1.2	1.4	1.4	1.3	-1.5	-1.5	1.5	-1.5
Mean time between licks in bursts	1.1	6.5	6.7	-2.5	-2.6	-2.6	-2.4	2.6	2.6	-2.6	2.6
Mean num. licks in bursts	0.0	0.1	0.1	0.1	0.2	0.2	0.3	-0.3	-0.3	0.3	-0.3
Cd content in liver	0.2	0.2	0.4	-0.6	-0.5	-0.5	-0.5	0.4	0.4	-0.4	0.4
Co content in liver	1.7	2.0	2.3	-1.3	-1.4	-1.4	-1.1	1.5	1.5	-1.5	1.5
Cu content in liver	0.3	0.4	1.4	-0.8	-0.6	-0.5	-1.2	0.2	0.3	-0.3	0.2
Fe content in liver	0.2	0.2	0.3	-0.3	-0.4	-0.4	-0.6	0.5	0.5	-0.5	0.5
K content in liver	0.1	0.1	0.4	-0.5	-0.3	-0.2	-0.6	-0.1	-0.0	0.0	-0.1
Mg content in liver	0.3	0.3	0.6	-0.8	-0.6	-0.6	-0.8	0.5	0.4	-0.4	0.5
Mn content in liver	1.5	1.7	3.9	-1.7	-1.4	-1.4	-2.0	0.8	0.7	-0.7	0.8
Na content in liver	0.8	0.9	1.3	0.5	0.8	0.9	-0.0	-1.2	-1.1	1.1	-1.2
Rb content in liver	0.1	0.1	0.2	-0.5	-0.2	-0.2	-0.4	-0.2	-0.3	0.3	-0.2
Se content in liver	0.3	0.3	0.6	-0.5	-0.5	-0.5	-0.8	0.5	0.5	-0.5	0.5
Sr content in liver	0.0	0.0	0.1	0.2	0.1	0.1	0.3	0.0	0.0	-0.0	0.0
Zn content in liver	3.9	4.6	6.4	-1.6	-2.0	-2.0	-1.3	2.4	2.5	-2.5	2.4
Bone: minimum diameter	0.0	0.0	0.1	-0.1	0.1	0.1	0.0	-0.3	-0.3	0.3	-0.3
Time in familiar zone, hab. session 1	1.7	1.9	2.4	-1.3	-1.4	-1.4	-0.6	1.5	1.4	-1.4	1.5
Time in novel zone, hab. session 1	0.9	1.0	1.4	0.9	0.9	1.0	0.3	-1.2	-1.1	1.1	-1.2
Total zone transitions, hab. session 1	1.0	1.4	3.8	-1.6	-1.3	-1.2	-2.0	0.7	0.7	-0.7	0.7
Total locomotion distance, hab. session 1	1.2	1.7	4.9	-1.9	-1.4	-1.3	-2.2	0.7	0.6	-0.6	0.7
Locomotion velocity, hab. session 1	1.8	2.5	6.0	-2.2	-1.7	-1.6	-2.5	1.0	1.0	-1.0	1.0
Time in familiar zone, hab. session 2	5.7	6.5	7.8	-2.3	-2.5	-2.6	-1.6	2.8	2.8	-2.8	2.8
Time in novel zone, hab. session 2	4.4	4.8	5.9	1.9	2.2	2.2	1.4	-2.4	-2.4	2.4	-2.4
Total zone transitions, hab. session 2	0.5	0.6	1.5	-0.4	0.1	0.3	-1.2	-0.9	-0.9	0.9	-0.9
Total locomotion distance, hab. session 2	1.3	1.6	4.3	-1.8	-1.4	-1.2	-2.1	0.7	0.7	-0.7	0.7
Locomotion velocity, hab. session 2	1.3	1.8	5.4	-1.9	-1.4	-1.2	-2.3	0.6	0.6	-0.6	0.6
Novel to familiar place preference ratio	3.3	4.3	5.6	1.8	2.0	2.1	1.1	-2.4	-2.3	2.3	-2.4
Novelty place preference	2.0	2.6	3.5	1.4	1.5	1.6	0.7	-1.9	-1.8	1.8	-1.9
Time in novel zone, NPP test	2.5	3.0	3.9	1.5	1.7	1.7	0.9	-2.0	-1.9	1.9	-2.0
Total zone transitions, NPP test	0.2	0.3	1.3	-0.6	-0.2	-0.1	-1.2	-0.4	-0.4	0.4	-0.4
Total locomotion distance, NPP test	0.2	0.3	0.9	-0.6	-0.2	-0.0	-0.9	-0.5	-0.5	0.5	-0.5
Locomotion velocity, NPP test	0.2	0.3	1.5	-0.9	-0.5	-0.3	-1.2	-0.2	-0.2	0.2	-0.2
Intraocular pressure	0.1	0.2	1.0	0.5	0.2	0.1	1.0	0.4	0.4	-0.4	0.4
Delta distance traveled before/after self-admin	0.3	0.4	0.8	-0.6	-0.6	-0.6	0.0	0.6	0.6	-0.7	0.9
Delta ambulatory time before/after self-admin	0.2	0.3	0.7	-0.6	-0.6	-0.6	-0.3	0.5	0.5	-0.6	0.8
Parametrial fat weight	0.0	0.0	0.2	-0.2	-0.1	-0.0	-0.4	-0.1	-0.1	0.1	-0.1
Pavlov. Cond. lever latency	0.1	0.2	0.5	0.6	0.2	0.1	0.7	0.3	0.3	-0.3	0.3
Pavlov. Cond. magazine entry latency	3.1	3.9	4.4	-2.1	-2.1	-2.0	-1.9	2.0	1.9	-1.9	2.0
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.3	-0.3	-0.2	-0.4	0.2	0.2	-0.2	0.2
Pavlov. Cond. index score	0.4	0.5	1.0	-1.0	-0.8	-0.8	-1.0	0.5	0.5	-0.5	0.5
Pavlov. Cond. latency score	0.4	0.5	1.3	-1.1	-0.8	-0.7	-1.1	0.4	0.4	-0.4	0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.4	-0.5	-0.1	-0.0	-0.7	-0.3	-0.3	0.3	-0.3
Pavlov. Cond. magazine entry number	0.8	1.0	1.1	1.0	1.1	1.0	0.9	-1.0	-0.9	0.9	-1.0
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.3	-0.2	-0.3	-0.3	0.1	0.6	0.6	-0.6	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.1	-1.1	-0.9	-0.9	-1.1	0.6	0.6	-0.6	0.6
Pavlov. Cond. response bias	0.8	1.0	1.2	-1.1	-1.1	-1.0	-0.9	1.0	0.9	-0.9	1.0
Pavlov. Cond. lever latency	0.6	0.9	1.2	0.8	0.9	1.0	0.2	-1.1	-1.1	1.1	-1.1
Pavlov. Cond. magazine entry latency	0.3	0.4	0.5	-0.5	-0.6	-0.7	-0.5	0.7	0.7	-0.7	0.7
Pavlov. Cond. change in total contacts	0.3	0.8	1.1	-0.7	-0.8	-0.9	-0.3	1.0	1.1	-1.1	1.0
Pavlov. Cond. index score	0.5	0.8	1.1	-0.7	-0.8	-0.9	-0.3	1.0	1.0	-1.0	1.0
Pavlov. Cond. latency score	0.5	0.8	1.0	-0.8	-0.9	-1.0	-0.5	1.0	1.0	-1.0	1.0
Pavlov. Cond. lever contacts	0.5	0.7	1.0	-0.6	-0.7	-0.8	0.0	1.0	1.0	-1.0	1.0
Pavlov. Cond. magazine entry number	0.6	0.7	0.9	0.7	0.9	0.9	0.7	-0.9	-1.0	1.0	-0.9
Pavlov. Cond. intertrial magazine entries	0.3	0.5	2.0	0.7	0.7	0.7	1.4	-0.5	-0.5	0.5	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.8	1.0	-0.8	-0.9	-1.0	-0.5	1.0	1.0	-1.0	1.0
Pavlov. Cond. response bias	1.4	2.0	2.6	-1.1	-1.3	-1.4	-0.4	1.6	1.6	-1.6	1.6
Time in closed arm before self-admin	0.3	0.6	1.2	0.3	0.5	0.6	0.5	-0.9	-1.1	1.1	-0.8
Time in closed arm after self-admin	0.2	0.2	0.7	-0.2	-0.3	-0.3	0.8	0.5	0.4	-0.4	0.6
Time in open arm before self-admin	0.3	0.4	1.1	-0.4	-0.4	-0.5	-1.1	0.5	0.6	-0.5	0.6
Time in open arm after self-admin	0.8	0.9	1.1	1.0	1.1	1.0	0.1	-1.1	-0.9	0.9	-1.0
Bone: periosteal estimation	0.2	0.5	0.9	0.3	0.6	0.6	0.4	-0.9	-0.9	0.9	-0.9
Bone: periosteal perimeter	0.1	0.1	0.4	-0.7	-0.4	-0.4	-0.6	0.1	0.1	-0.1	0.1
Bone: post-yield work	0.6	1.0	1.2	1.0	1.1	1.0	1.1	-1.0	-1.0	1.0	-1.0
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	0.3	-0.1	-0.1	-0.1	0.5	0.4	-0.4	0.3
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	0.3	-0.0	-0.1	-0.0	0.5	0.4	-0.4	0.3
Progressive ratio test 1 inactive lever presses	0.1	0.4	0.7	-0.3	-0.5	-0.5	-0.4	0.7	0.8	-0.8	0.6
Progressive ratio test 2 active lever presses	0.3	0.5	0.9	0.1	-0.3	-0.4	-0.7	0.9	0.9	-0.9	0.7
Progressive ratio test 2 breakpoint	0.4	0.6	1.0	0.0	-0.4	-0.5	-0.8	1.0	1.0	-1.0	0.7
Progressive ratio test 2 inactive lever presses	0.1	0.3	1.1	-0.2	-0.4	-0.4	-1.1	0.6	0.6	-0.6	0.4
Incentive Sensitization - Responses	0.0	0.1	0.3	0.5	0.2	0.1	-0.5	0.4	0.3	-0.3	0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.4	0.4	0.1	-0.0	-0.6	0.5	0.4	-0.4	0.3
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.3	0.1	0.1	0.1	0.6	0.0	0.2	-0.0	-0.0
Progressive ratio	0.1	0.3	0.5	0.6	0.6	0.7	-0.2	-0.5	-0.4	0.4	-0.5
Food seeking constrained by brief footshock	0.2	0.2	0.7	-0.7	-0.6	-0.4	-0.8	0.3	0.3	-0.3	0.3
Seeking ratio, punishment vs. effort	0.1	0.3	0.6	-0.8	-0.7	-0.7	-0.1	0.4	0.4	-0.4	0.4
Retroperitoneal fat weight	0.4	1.8	2.6	1.6	1.4	1.4	1.6	-1.2	-1.0	1.0	-1.2
Reaction time number correct	0.2	0.8	2.3	1.4	1.0	0.9	1.5	-0.4	-0.5	0.5	-0.4
Reaction time mean minus median	0.1	0.7	0.9	-0.7	-0.8	-0.9	-0.7	1.0	1.0	-1.0	0.9
Reaction time mean minus median AUC	0.0	0.1	0.2	-0.2	0.0	-0.0	-0.4	-0.2	-0.3	0.3	-0.3
Reaction time num false alarms	0.1	0.2	0.6	0.8	0.6	0.5	0.6	-0.2	-0.1	0.1	-0.2
Reaction time num false alarms AUC	0.1	0.2	0.8	0.9	0.6	0.5	0.7	-0.2	-0.1	0.1	-0.2
Reaction time trials correct on left	0.2	0.8	2.3	1.4	1.0	0.9	1.5	-0.4	-0.5	0.5	-0.4
Reaction time trials on left	0.2	0.8	2.2	1.4	1.0	0.9	1.5	-0.4	-0.5	0.5	-0.5
Reaction time mean	0.0	0.1	0.1	-0.0	0.1	0.1	-0.3	-0.3	-0.3	0.3	-0.3
Reaction time mean AUC	0.0	0.1	0.1	0.0	0.2	0.2	-0.2	-0.4	-0.3	0.3	-0.3
Median of all reaction times	0.2	0.4	0.6	0.4	0.6	0.6	0.1	-0.8	-0.8	0.8	-0.7
Reaction time omissions	0.2	0.3	0.6	-0.7	-0.5	-0.5	-0.8	0.3	0.3	-0.3	0.2
Reaction time false alarm rate	0.0	0.0	0.1	0.2	0.3	0.2	0.1	-0.2	-0.1	0.1	-0.2
Reaction time premature initiation rate	0.9	1.4	1.8	-0.9	-1.1	-1.1	-0.8	1.3	1.3	-1.3	1.3
Reaction time premature initiations	0.3	0.8	1.6	-0.3	-0.7	-0.8	-0.0	1.3	1.1	-1.1	1.2
Std. dev. reaction times	0.1	0.2	0.3	-0.5	-0.4	-0.4	-0.6	0.4	0.4	-0.4	0.4
Reaction time trials completed	0.2	0.8	2.2	1.4	1.0	0.9	1.5	-0.4	-0.5	0.5	-0.5
Reaction time trials AUC	0.2	0.8	2.3	1.4	1.0	0.9	1.5	-0.3	-0.4	0.4	-0.4
Run reversals in cocaine runway, females	0.5	0.5	0.9	-0.9	-0.8	-0.8	-0.8	0.6	0.6	-0.6	0.5
Run reversals in cocaine runway, males	1.3	1.4	2.5	-1.6	-1.4	-1.4	-0.5	1.1	1.1	-1.1	1.1
Latency to leave start box in cocaine runway	0.5	0.7	1.4	-1.1	-0.9	-0.9	-1.2	0.6	0.6	-0.6	0.4
Latency to leave start box in cocaine runway, F	0.1	0.2	0.5	-0.5	-0.1	-0.1	-0.7	-0.2	-0.2	0.2	-0.5
Latency to leave start box in cocaine runway, M	1.9	1.9	2.3	-1.2	-1.3	-1.3	-0.9	1.5	1.5	-1.5	1.5
Std. dev. time between licks in bursts	0.5	1.0	1.6	-1.1	-1.0	-1.0	-1.3	0.8	0.8	-0.8	0.8
Total sessions with >9 infusions	0.3	0.4	0.8	-0.1	-0.4	-0.5	-0.3	0.9	0.8	-0.8	0.6
Short access day 1 total inactive lever presses	0.3	0.5	1.2	-0.5	-0.6	-0.6	-1.1	0.8	0.7	-0.7	0.7
Short access day 10 total inactive lever presses	0.0	0.1	0.4	0.2	0.1	0.0	0.1	0.3	0.6	-0.6	0.3
Short access day 1 total infusions	0.2	0.4	0.6	-0.5	-0.6	-0.6	-0.7	0.7	0.6	-0.6	0.6
Short access day 10 total infusions	0.1	0.1	0.3	0.1	-0.1	-0.2	-0.2	0.5	0.5	-0.5	0.2
Short access total infusions	0.3	0.4	0.8	-0.3	-0.5	-0.6	-0.8	0.9	0.8	-0.8	0.5
Short access day 1 locomotion	1.0	1.7	2.4	-1.0	-1.3	-1.3	-0.9	1.5	1.5	-1.5	1.3
Short access day 10 total locomotion	2.0	8.2	10.9	-2.2	-2.7	-2.8	-2.3	3.3	3.2	-3.2	3.0
Short access total locomotion	2.0	3.0	4.3	-1.3	-1.6	-1.7	-1.1	2.1	2.0	-2.0	1.7
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.3	0.2	0.1	-0.4	0.1	0.0	-0.0	-0.1
Compulsive drug intake	0.8	1.2	1.9	0.6	0.9	1.0	0.5	-1.3	-1.4	1.4	-1.4
One hour access (shock baseline)	0.2	0.6	0.9	-0.3	-0.6	-0.6	-0.7	1.0	0.9	-0.9	0.8
Social response proportion	0.9	1.2	3.1	-1.3	-1.1	-1.0	-1.8	0.7	0.8	-0.8	0.8
Social responses	7.2	9.5	11.1	-3.3	-3.2	-3.2	-3.2	2.9	3.0	-3.0	2.9
Social time	0.3	0.5	0.6	0.6	0.7	0.8	0.7	-0.8	-0.7	0.7	-0.7
Soleus weight	8.9	26.2	27.5	5.1	5.2	5.2	5.2	-5.0	-5.1	5.1	-5.0
Bone: stiffness	2.5	4.6	5.1	1.9	2.1	2.1	1.8	-2.3	-2.3	2.3	-2.3
Tibialis anterior weight	1.1	3.8	4.5	2.0	2.0	2.0	2.1	-2.0	-1.7	1.7	-2.0
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	-0.4	-0.3	-0.3	0.6	0.2	0.3	-0.2	0.2
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.6	-0.1	-0.4	-0.4	0.2	0.7	0.8	-0.7	0.7
Time to tail flick, test, before self-admin	0.2	0.3	0.6	-0.7	-0.6	-0.6	-0.7	0.4	0.1	-0.2	0.5
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.3	-0.3	-0.3	0.3	0.2	0.1	-0.3	0.3
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.7	0.9	0.6	0.5	0.5	-0.2	-0.2	0.2	-0.3
Delta time to tail flick, test, before/after SA	0.1	0.1	0.5	0.3	0.1	0.1	0.7	0.1	0.2	-0.3	0.2
Tibia length	0.9	2.5	2.7	-1.5	-1.5	-1.6	-1.6	1.6	1.6	-1.6	1.6
Ambulatory time before self-admin	0.0	0.1	0.4	0.3	0.3	0.3	0.3	-0.3	-0.2	0.2	-0.6
Ambulatory time after self-admin	0.0	0.0	0.0	-0.1	-0.0	-0.1	0.1	-0.0	0.1	-0.1	-0.0
Bone: tissue strength	1.8	1.8	2.2	1.2	1.4	1.4	1.0	-1.5	-1.5	1.5	-1.5
Total heroin consumption	1.6	1.9	2.3	-1.5	-1.5	-1.4	-1.1	1.3	1.5	-1.3	1.3
Bone: trabecular number	0.3	0.6	1.2	-1.1	-0.9	-0.8	-1.1	0.4	0.4	-0.4	0.4
Bone: trabecular spacing	0.5	0.7	2.4	1.3	0.9	0.8	1.5	-0.1	-0.1	0.1	-0.1
Bone: trabecular thickness	0.4	0.5	1.3	-0.8	-0.1	-0.1	-1.2	-0.7	-0.7	0.7	-0.7
Bone: trabecular tissue density	1.0	1.8	2.1	1.4	1.4	1.5	1.3	-1.3	-1.3	1.3	-1.3
Water consumed over 24 hours	0.5	1.1	1.6	0.8	1.0	0.9	1.3	-1.1	-1.1	1.1	-1.1
Number of responses in last shaping day	1.4	1.8	2.8	-0.9	-1.2	-1.3	-0.7	1.7	1.6	-1.6	1.4