Hub : Genes

Rexo1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain isoform ratio XR_005486605.2 0.04 0.03 5.4e-04 0.02 0.02 0.03 0.02 4.5e-03 4.3e-03 1.6e-03 7.6e-03
2 Brain isoform ratio XM_063263421.1 0.05 0.04 1.9e-05 0.04 0.04 0.03 0.03 3.1e-04 2.0e-04 1.7e-03 3.5e-04
3 PL mRNA stability Rexo1 0.03 0.02 3.5e-04 0.03 0.03 0.03 0.03 4.9e-04 1.4e-04 2.9e-04 3.2e-04
4 NAcc gene expression Rexo1 0.02 0.01 2.8e-03 0.01 0.01 0.01 0 2.5e-02 2.3e-02 1.6e-02 6.2e-02
5 Brain mRNA stability Rexo1 0.04 0.03 6.6e-04 0.03 0.03 0.03 0.03 3.8e-04 4.3e-04 8.3e-04 4.1e-04
6 PL isoform ratio XM_063263421.1 0.02 0.01 5.3e-03 0.01 0.01 0 0.01 8.3e-03 2.4e-02 1.0e-01 4.3e-02
7 Brain gene expression Rexo1 0.09 0.07 9.3e-08 0.08 0.06 0.06 0.07 8.8e-08 1.4e-06 5.3e-06 2.2e-07
8 Liver isoform ratio XM_063263421.1 0.02 0.02 2.2e-03 0.02 0.02 0.01 0.01 4.4e-03 5.2e-03 9.1e-03 1.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.20.30.50.50.10.10.60.70.7-0.70.7
Area under the delay curve2.32.73.4-1.41.71.6-1.91.71.6-1.61.7
BMI with tail6.522.424.5-4.94.94.9-4.54.64.7-4.74.6
BMI without tail2.16.38.2-2.92.72.6-2.72.32.3-2.32.2
Body weight0.94.04.4-2.12.12.1-1.92.02.0-2.01.9
Weight adjusted by age0.30.41.0-1.00.80.7-0.70.40.5-0.50.4
Bone surface0.30.61.91.4-0.7-0.61.30.30.3-0.30.3
Bone volume0.30.51.71.3-0.6-0.51.20.30.3-0.30.3
Breakpoint value in progressive ratio session3.74.45.92.0-2.2-2.21.2-2.3-2.42.3-2.1
Number of licking bursts0.00.10.2-0.50.20.2-0.4-0.2-0.20.2-0.2
Context. condit. distance diff. score0.40.50.7-0.80.70.7-0.90.60.6-0.60.6
Locomotion velocity, session 10.50.61.61.1-0.8-0.81.2-0.4-0.50.5-0.4
Locomotion distance, session 10.40.52.41.0-0.6-0.51.60.10.1-0.10.1
Locomotion velocity, session 23.94.58.52.7-2.3-2.22.9-1.5-1.61.6-1.5
Locomotion distance, session 22.02.87.52.2-1.8-1.62.7-1.0-1.01.0-1.0
Locomotion velocity, session 36.06.97.32.6-2.7-2.72.2-2.6-2.72.7-2.6
Locomotion distance, session 30.00.00.1-0.20.10.0-0.3-0.0-0.10.1-0.0
Stereotopy head waving bouts, day 35.05.98.02.8-2.6-2.52.6-2.2-2.22.2-2.2
Stereotopy head waving duration, day 36.07.19.23.0-2.8-2.82.6-2.5-2.52.5-2.5
Locomotion velocity, session 70.40.40.60.5-0.6-0.70.3-0.8-0.80.8-0.8
Locomotion distance, session 70.20.31.0-0.90.60.5-1.00.10.1-0.10.1
Stereotopy head waving bouts, day 70.10.10.20.4-0.10.00.40.40.4-0.40.4
Stereotopy head waving duration, day 70.30.41.11.0-0.7-0.61.0-0.2-0.20.2-0.2
Locomotion velocity, session 80.60.72.31.2-0.9-0.81.5-0.3-0.30.3-0.3
Locomotion distance, session 80.20.20.70.6-0.5-0.40.9-0.2-0.20.2-0.2
Degree of sensitization distance0.50.50.6-0.70.70.7-0.70.70.7-0.70.7
Degree of sensitization stereotypy1.81.92.5-1.11.31.3-0.91.61.5-1.51.6
Conditioned locomotion1.31.52.9-1.61.41.3-1.70.91.0-1.00.9
Cocaine response after cond. corrected5.36.49.8-3.02.82.7-3.12.12.1-2.12.1
Cocaine response after cond. not corrected5.86.810.8-3.12.82.7-3.32.22.2-2.22.2
Cocaine response before conditioning0.40.50.70.8-0.8-0.80.3-0.7-0.60.6-0.7
Saline control response0.20.21.2-0.50.40.4-1.10.20.2-0.20.2
Bone: connectivity density0.30.50.9-0.10.50.50.21.01.0-1.01.0
Bone: cortical apparent density0.91.21.4-1.11.11.1-1.21.11.1-1.11.1
Bone: cortical area0.40.71.0-0.40.70.7-0.51.01.0-1.01.0
Bone: cortical porosity0.20.20.70.6-0.4-0.40.9-0.2-0.20.2-0.2
Bone: cortical porosity0.10.10.50.4-0.2-0.10.70.20.2-0.20.2
Bone: cortical thickness1.01.72.1-1.01.31.3-1.11.51.5-1.51.5
Bone: cortical thickness0.10.10.2-0.20.0-0.1-0.4-0.4-0.40.4-0.4
Bone: cortical tissue density0.60.81.0-0.90.90.9-1.00.90.9-0.90.9
Condit. Reinf. active minus inactive responses4.24.75.22.3-2.3-2.32.0-2.1-2.22.2-2.1
Condit. Reinf. active-inactive response ratio2.12.22.81.3-1.5-1.51.0-1.6-1.71.7-1.6
Condit. Reinf. active responses3.84.76.62.6-2.3-2.32.5-1.9-1.91.9-1.9
Condit. Reinf. inactive responses1.01.23.41.4-1.2-1.11.8-0.6-0.60.6-0.6
Incentive salience index mean2.32.84.02.0-1.8-1.82.0-1.4-1.51.5-1.4
Condit. Reinf. lever presses0.20.31.60.8-0.4-0.31.20.30.2-0.20.3
Condit. Reinf. active minus inactive responses2.33.03.91.4-1.6-1.71.0-1.9-2.02.0-1.9
Condit. Reinf. active-inactive response ratio0.20.20.4-0.0-0.2-0.20.1-0.6-0.60.6-0.6
Condit. Reinf. active responses2.23.03.71.7-1.7-1.80.9-1.9-1.91.9-1.9
Condit. Reinf. inactive responses0.91.21.61.2-1.1-1.20.2-1.2-1.21.2-1.2
Condit. Reinf. lever presses1.82.53.21.3-1.5-1.60.7-1.8-1.81.8-1.8
Condit. Reinf. lever reinforcers received1.62.22.91.3-1.4-1.50.5-1.7-1.71.7-1.7
Conditioned reinforcement - actives1.11.82.50.7-1.1-1.21.6-1.6-1.51.5-1.5
Conditioned reinforcement - inactives0.00.00.2-0.40.20.20.1-0.1-0.10.10.1
Conditioned locomotion8.110.611.63.1-3.2-3.33.2-3.3-3.43.4-3.1
Patch foraging indifference point 0 sec0.20.30.4-0.40.50.5-0.50.50.6-0.60.5
Patch foraging indifference point AUC1.01.41.71.1-1.1-1.11.2-1.2-1.31.3-1.2
Delay disc. indifference point, 0s delay7.48.210.8-2.32.72.8-1.53.23.2-3.33.3
Delay disc. indifference point, 16s delay0.30.30.7-0.30.40.4-0.80.60.5-0.40.5
Delay disc. indifference point, 2s delay6.67.38.2-2.52.72.7-2.52.82.8-2.92.8
Delay disc. indifference point, 24s delay0.60.71.2-1.00.90.9-1.10.90.7-0.60.7
Delay disc. indifference point, 4s delay1.61.72.3-0.91.21.2-1.31.51.4-1.31.4
Delay disc. indifference point, 8s delay1.21.41.9-1.21.31.3-1.41.11.0-1.01.1
Indifference point function ln k0.20.30.7-0.70.60.5-0.90.40.4-0.40.4
Indifference point function log k0.20.30.7-0.70.60.5-0.90.40.4-0.40.4
Patch foraging total patch changes 0 sec0.10.20.3-0.40.40.4-0.40.50.5-0.50.5
Patch foraging total patch changes 12 sec0.30.40.7-0.90.70.7-0.60.50.5-0.50.5
Patch foraging total patch changes 18 sec0.81.21.41.2-1.1-1.11.0-1.1-1.01.0-1.1
Patch foraging total patch changes 24 sec0.00.10.20.4-0.4-0.3-0.0-0.3-0.20.2-0.3
Patch foraging total patch changes 6 sec0.30.40.90.8-0.6-0.61.0-0.5-0.50.5-0.5
Patch foraging time to switch 0 sec1.02.13.5-0.81.11.3-0.31.91.8-1.81.7
Patch foraging water rate 0 sec0.10.30.4-0.70.20.1-0.7-0.6-0.50.5-0.5
Patch foraging water rate 12 sec0.81.63.8-1.81.41.3-2.00.70.8-0.80.8
Patch foraging water rate 18 sec0.50.71.5-0.70.1-0.1-1.2-1.1-0.90.9-0.9
Patch foraging water rate 24 sec0.50.72.3-1.50.90.8-1.5-0.1-0.00.00.0
Patch foraging water rate 6 sec0.50.71.3-0.1-0.4-0.5-0.6-1.1-1.11.1-1.1
Seeking ratio, delayed vs. immediate footshock3.74.65.72.4-2.3-2.31.4-2.1-2.22.2-2.1
Distance traveled before self-admin0.10.10.4-0.30.30.3-0.30.40.3-0.30.6
Distance traveled after self-admin0.00.00.10.1-0.1-0.2-0.1-0.1-0.20.3-0.1
Extensor digitorum longus weight4.317.120.5-4.54.44.4-4.33.93.8-3.83.9
Bone: elastic displacement0.20.20.40.5-0.4-0.50.6-0.4-0.40.4-0.4
Bone: elastic work0.30.40.5-0.50.70.6-0.60.70.7-0.70.7
Bone: endosteal estimation0.20.40.5-0.50.60.6-0.50.70.7-0.70.7
Bone: endosteal perimeter0.20.50.80.9-0.8-0.80.9-0.5-0.50.5-0.5
Epididymis fat weight0.00.10.5-0.40.20.2-0.7-0.3-0.20.2-0.1
Delta time in closed arm before/after self-admin0.80.82.4-1.40.90.8-1.60.10.1-0.10.2
Delta time in open arm before/after self-admin0.60.60.8-0.70.80.8-0.70.90.8-0.80.9
Diff in mean of infusions in LGA sessions1.61.92.61.5-1.5-1.41.0-1.3-1.61.4-1.2
Delay discount exponential model param2.02.33.21.3-1.5-1.51.8-1.6-1.41.4-1.5
Extinction: sum of active levers before priming1.01.21.80.8-1.0-1.00.4-1.4-1.31.3-1.1
Active lever presses in extinction session 62.82.83.21.6-1.6-1.71.7-1.7-1.81.8-1.5
Bone: final force1.42.22.7-1.11.51.4-1.31.61.6-1.61.6
Bone: final moment1.11.82.2-1.01.31.3-1.21.51.5-1.51.5
Food consumed during 24 hour testing period0.60.81.5-1.00.90.9-1.20.80.8-0.80.8
Glucose2.64.14.7-2.22.12.1-2.02.01.9-1.92.0
Heart weight0.50.81.30.5-0.7-0.80.0-1.1-1.11.1-1.1
Delay discount hyperbolic model param3.43.84.81.8-2.0-1.92.2-2.0-1.91.9-2.0
Intermittent access intake day 1-15 change3.57.18.52.3-2.5-2.62.2-2.9-2.92.9-2.9
Intermittent access intake escalation3.06.27.42.1-2.4-2.52.0-2.7-2.72.7-2.7
Intermittent access intake escalation 24.75.46.52.1-2.3-2.31.7-2.5-2.52.5-2.5
Intermitt. access day 1 inactive lever presses0.10.51.2-0.2-0.2-0.3-0.0-0.8-1.11.1-0.6
Intermitt. access day 15 inactive lever presses0.30.50.90.7-0.7-0.71.0-0.6-0.80.8-0.6
Intermitt. access escalation Index0.60.91.4-0.60.80.9-0.11.21.2-1.21.1
Intermittent access day 1 total infusions0.10.20.5-0.0-0.2-0.30.2-0.6-0.70.7-0.4
Intermittent access day 15 total infusions2.74.05.11.6-1.8-1.91.7-2.2-2.32.3-2.0
Intermittent access terminal intake (last 3 days)2.12.73.51.2-1.5-1.61.5-1.9-1.91.9-1.6
Intermittent access total infusions1.11.41.80.7-1.0-1.11.3-1.4-1.31.3-1.1
Intermittent access day 1 locomotion1.41.82.80.9-1.2-1.30.9-1.7-1.61.6-1.4
Intermittent access day 15 total locomotion3.46.17.32.1-2.3-2.42.5-2.6-2.72.7-2.4
Intermittent access total locomotion2.63.14.01.4-1.6-1.71.6-2.0-2.02.0-1.8
Intermittent access standard deviation4.08.49.22.7-2.8-2.93.0-3.0-3.03.0-2.8
Left kidney weight0.00.10.5-0.50.30.2-0.7-0.2-0.20.2-0.2
Right kidney weight0.41.92.80.9-1.2-1.30.5-1.7-1.71.7-1.6
Cocaine induced anxiety1.11.62.91.7-1.4-1.31.6-0.9-0.90.9-1.0
Post-drug Anxiety1.11.12.81.7-1.3-1.21.0-0.7-0.70.7-0.7
Baseline Anxiety0.10.10.20.2-0.2-0.2-0.5-0.3-0.30.3-0.1
Tail length3.313.014.63.4-3.6-3.73.0-3.8-3.83.8-3.8
Length with tail1.98.39.12.8-2.9-2.92.5-3.0-3.03.0-3.0
Length without tail0.00.00.0-0.10.10.1-0.20.00.1-0.10.1
Times rat made contact with spout0.20.30.9-0.70.50.5-0.90.20.2-0.20.2
Lifetime Intake0.60.71.20.5-0.7-0.71.0-1.1-1.01.0-0.8
Liver weight, left1.01.71.9-1.31.31.3-1.41.21.3-1.31.3
Liver weight, right0.61.11.7-1.31.21.1-1.30.80.8-0.80.9
Locomotor activity3.14.87.02.6-2.4-2.42.0-2.0-2.02.0-2.0
Locomotor testing distance1.73.04.72.2-1.9-1.91.4-1.6-1.61.6-1.6
Locomotor testing rearing0.10.10.40.1-0.1-0.2-0.7-0.3-0.30.3-0.3
Locomotion in novel chamber1.31.62.21.1-1.2-1.21.0-1.3-1.51.5-1.3
Locomotion in novel chamber post-restriction0.91.51.91.1-1.2-1.30.0-1.3-1.31.3-1.4
Fecal boli incidents, locomotor time 11.11.62.0-1.31.41.4-1.21.21.2-1.31.3
Change in fecal boli incidents, locomotor task0.20.20.30.3-0.4-0.60.5-0.5-0.50.4-0.4
Time >=10cm from walls, locomotor time 10.30.30.5-0.30.50.50.40.70.7-0.60.6
Bouts of movement, locomotor time 10.30.40.60.4-0.6-0.60.8-0.7-0.70.7-0.7
Total resting periods, locomotor time 10.40.50.50.5-0.7-0.70.7-0.7-0.70.7-0.7
Rest time, locomotor task time 10.20.30.70.5-0.6-0.60.9-0.5-0.50.4-0.4
Distance moved, locomotor task time 10.50.71.2-0.60.80.8-0.21.11.1-1.01.0
Vertical activity count, locomotor time 10.10.30.6-0.70.60.5-0.80.30.3-0.30.3
Time >=10cm from walls, locomotor time 20.91.32.0-1.41.31.2-1.40.91.0-0.90.9
Bouts of movement, locomotor time 20.40.62.41.0-0.7-0.71.6-0.3-0.30.3-0.3
Total resting periods, locomotor time 20.30.52.31.0-0.7-0.61.5-0.2-0.20.3-0.3
Rest time, locomotor task time 20.60.71.11.1-0.9-0.91.0-0.6-0.60.7-0.7
Distance moved, locomotor task time 20.50.61.0-1.00.90.9-0.60.70.7-0.70.7
Vertical activity count, locomotor time 20.40.61.3-1.10.90.9-0.90.50.4-0.50.5
Light reinforcement 14.110.212.63.5-3.5-3.43.1-2.9-3.03.0-3.1
Light reinforcement 21.72.73.31.8-1.8-1.81.6-1.5-1.51.5-1.5
Bone: marrow area0.20.40.5-0.50.60.6-0.50.70.7-0.70.7
Bone: maximum diameter0.81.52.41.6-1.3-1.31.4-1.0-1.01.0-1.0
Bone: maximum force1.42.42.7-1.31.51.5-1.51.61.6-1.61.6
Bone: maximum moment1.22.02.3-1.21.41.4-1.31.51.5-1.51.5
Mean time between licks in bursts2.76.56.72.5-2.6-2.62.4-2.6-2.62.6-2.6
Mean num. licks in bursts0.00.10.1-0.10.20.2-0.30.30.3-0.30.3
Cd content in liver0.20.20.40.6-0.5-0.50.5-0.4-0.40.4-0.4
Co content in liver1.72.02.31.3-1.4-1.41.1-1.5-1.51.5-1.5
Cu content in liver0.30.41.30.8-0.6-0.51.2-0.2-0.30.3-0.2
Fe content in liver0.20.20.30.3-0.4-0.40.6-0.5-0.50.5-0.5
K content in liver0.10.10.40.5-0.3-0.20.60.10.0-0.00.1
Mg content in liver0.30.30.60.8-0.6-0.60.8-0.5-0.40.4-0.5
Mn content in liver1.51.63.81.7-1.4-1.41.9-0.8-0.70.7-0.8
Na content in liver0.80.91.3-0.50.80.90.01.21.1-1.11.2
Rb content in liver0.10.10.20.5-0.2-0.20.30.20.3-0.30.2
Se content in liver0.30.30.60.5-0.5-0.50.8-0.5-0.50.5-0.5
Sr content in liver0.00.00.1-0.20.10.1-0.3-0.0-0.00.0-0.0
Zn content in liver4.14.66.41.6-2.0-2.01.3-2.4-2.52.5-2.4
Bone: minimum diameter0.00.00.10.10.10.1-0.10.30.3-0.30.3
Time in familiar zone, hab. session 11.91.92.41.3-1.4-1.40.7-1.5-1.41.4-1.5
Time in novel zone, hab. session 11.01.01.4-0.90.91.0-0.31.21.1-1.11.2
Total zone transitions, hab. session 11.01.43.71.6-1.3-1.21.9-0.7-0.70.7-0.7
Total locomotion distance, hab. session 11.21.74.71.9-1.4-1.32.2-0.7-0.60.6-0.7
Locomotion velocity, hab. session 11.82.55.92.2-1.7-1.62.4-1.0-1.01.0-1.0
Time in familiar zone, hab. session 26.26.57.82.3-2.5-2.61.7-2.8-2.82.8-2.8
Time in novel zone, hab. session 24.84.95.9-1.92.22.2-1.52.42.4-2.42.4
Total zone transitions, hab. session 20.50.61.30.40.10.31.20.90.9-0.90.9
Total locomotion distance, hab. session 21.21.64.11.8-1.4-1.22.0-0.7-0.70.7-0.7
Locomotion velocity, hab. session 21.31.75.21.9-1.4-1.22.3-0.6-0.60.6-0.6
Novel to familiar place preference ratio4.04.35.6-1.82.02.1-1.12.42.3-2.32.4
Novelty place preference2.42.63.5-1.41.51.6-0.71.91.8-1.81.9
Time in novel zone, NPP test2.83.03.9-1.51.71.7-1.02.01.9-1.92.0
Total zone transitions, NPP test0.20.31.20.6-0.2-0.11.10.40.4-0.40.4
Total locomotion distance, NPP test0.20.30.80.6-0.2-0.00.90.50.5-0.50.5
Locomotion velocity, NPP test0.20.31.40.9-0.5-0.31.20.20.2-0.20.2
Intraocular pressure0.20.20.9-0.50.20.1-1.0-0.4-0.40.4-0.4
Delta distance traveled before/after self-admin0.40.40.80.6-0.6-0.6-0.0-0.6-0.60.7-0.9
Delta ambulatory time before/after self-admin0.30.30.70.6-0.6-0.60.3-0.5-0.50.6-0.8
Parametrial fat weight0.00.00.10.2-0.1-0.00.40.10.1-0.10.1
Pavlov. Cond. lever latency0.10.20.5-0.60.20.1-0.7-0.3-0.30.3-0.3
Pavlov. Cond. magazine entry latency3.13.94.42.1-2.1-2.01.9-2.0-1.91.9-2.0
Pavlov. Cond. change in total contacts0.10.10.20.3-0.3-0.20.4-0.2-0.20.2-0.2
Pavlov. Cond. index score0.40.51.01.0-0.8-0.81.0-0.5-0.50.5-0.5
Pavlov. Cond. latency score0.40.51.31.1-0.8-0.71.1-0.4-0.40.4-0.4
Pavlov. Cond. lever contacts0.10.10.40.5-0.1-0.00.60.30.3-0.30.3
Pavlov. Cond. magazine entry number0.81.01.1-1.01.11.0-0.91.00.9-0.91.0
Pavlov. Cond. intertrial magazine entries0.20.20.30.2-0.3-0.3-0.1-0.6-0.60.6-0.6
Pavlov. Cond. lever-magazine prob. diff.0.60.71.11.1-0.9-0.91.1-0.6-0.60.6-0.6
Pavlov. Cond. response bias0.81.01.21.1-1.1-1.01.0-1.0-0.90.9-1.0
Pavlov. Cond. lever latency0.70.91.2-0.80.91.0-0.31.11.1-1.11.1
Pavlov. Cond. magazine entry latency0.40.40.50.5-0.6-0.70.5-0.7-0.70.7-0.7
Pavlov. Cond. change in total contacts0.50.81.10.7-0.8-0.90.3-1.0-1.11.1-1.0
Pavlov. Cond. index score0.60.81.10.7-0.8-0.90.3-1.0-1.01.0-1.0
Pavlov. Cond. latency score0.60.81.00.8-0.9-1.00.5-1.0-1.01.0-1.0
Pavlov. Cond. lever contacts0.50.71.00.6-0.7-0.80.0-1.0-1.01.0-1.0
Pavlov. Cond. magazine entry number0.60.70.9-0.70.90.9-0.70.91.0-1.00.9
Pavlov. Cond. intertrial magazine entries0.40.51.9-0.70.70.7-1.40.50.5-0.50.5
Pavlov. Cond. lever-magazine prob. diff.0.60.81.00.8-0.9-1.00.5-1.0-1.01.0-1.0
Pavlov. Cond. response bias1.42.02.61.1-1.3-1.40.5-1.6-1.61.6-1.6
Time in closed arm before self-admin0.50.61.2-0.30.50.6-0.50.91.1-1.10.8
Time in closed arm after self-admin0.20.20.60.2-0.3-0.3-0.8-0.5-0.40.4-0.6
Time in open arm before self-admin0.30.41.10.4-0.4-0.51.0-0.5-0.60.5-0.6
Time in open arm after self-admin0.80.91.1-1.01.11.0-0.21.10.9-0.91.0
Bone: periosteal estimation0.30.50.9-0.30.60.6-0.40.90.9-0.90.9
Bone: periosteal perimeter0.10.10.40.7-0.4-0.40.5-0.1-0.10.1-0.1
Bone: post-yield work0.71.01.2-1.01.11.0-1.11.01.0-1.01.0
Progressive ratio test 1 active lever presses0.10.10.3-0.3-0.1-0.10.1-0.5-0.40.4-0.3
Progressive ratio test 1 breakpoint0.10.10.3-0.3-0.0-0.10.1-0.5-0.40.4-0.3
Progressive ratio test 1 inactive lever presses0.30.40.70.3-0.5-0.50.4-0.7-0.80.8-0.6
Progressive ratio test 2 active lever presses0.40.50.9-0.1-0.3-0.40.8-0.9-0.90.9-0.7
Progressive ratio test 2 breakpoint0.50.61.0-0.0-0.4-0.50.8-1.0-1.01.0-0.7
Progressive ratio test 2 inactive lever presses0.20.31.10.2-0.4-0.41.0-0.6-0.60.6-0.4
Incentive Sensitization - Responses0.10.10.3-0.50.20.10.5-0.4-0.30.3-0.2
Incentive Sensitization - Breakpoint0.10.10.4-0.40.1-0.00.6-0.5-0.40.4-0.3
Sum of active levers in priming session hrs 5-60.10.00.3-0.10.10.1-0.6-0.0-0.20.00.0
Progressive ratio0.20.30.5-0.60.60.70.20.50.4-0.40.5
Food seeking constrained by brief footshock0.20.20.60.7-0.6-0.40.8-0.3-0.30.3-0.3
Seeking ratio, punishment vs. effort0.20.30.60.8-0.7-0.70.1-0.4-0.40.4-0.4
Retroperitoneal fat weight0.41.82.6-1.61.41.4-1.61.21.0-1.01.2
Reaction time number correct0.40.82.2-1.41.00.9-1.50.40.5-0.50.4
Reaction time mean minus median0.30.70.90.7-0.8-0.90.7-1.0-1.01.0-0.9
Reaction time mean minus median AUC0.00.10.20.20.0-0.00.40.20.3-0.30.3
Reaction time num false alarms0.10.20.6-0.80.60.5-0.60.20.1-0.10.2
Reaction time num false alarms AUC0.20.20.8-0.90.60.5-0.60.20.1-0.10.2
Reaction time trials correct on left0.40.82.2-1.41.00.9-1.50.40.5-0.50.4
Reaction time trials on left0.40.82.2-1.41.00.9-1.50.40.5-0.50.5
Reaction time mean0.00.10.10.00.10.10.20.30.3-0.30.3
Reaction time mean AUC0.00.10.1-0.00.20.20.20.40.3-0.30.3
Median of all reaction times0.30.40.6-0.40.60.6-0.10.80.8-0.80.7
Reaction time omissions0.20.20.60.7-0.5-0.50.8-0.3-0.30.3-0.2
Reaction time false alarm rate0.00.00.1-0.20.30.2-0.10.20.1-0.10.2
Reaction time premature initiation rate1.01.41.80.9-1.1-1.10.8-1.3-1.31.3-1.3
Reaction time premature initiations0.50.81.60.3-0.7-0.80.1-1.3-1.11.1-1.2
Std. dev. reaction times0.10.20.30.5-0.4-0.40.6-0.4-0.40.4-0.4
Reaction time trials completed0.40.82.2-1.41.00.9-1.50.40.5-0.50.5
Reaction time trials AUC0.40.82.2-1.41.00.9-1.50.30.4-0.40.4
Run reversals in cocaine runway, females0.50.50.90.9-0.8-0.80.8-0.6-0.60.6-0.5
Run reversals in cocaine runway, males1.41.42.51.6-1.4-1.40.5-1.1-1.11.1-1.1
Latency to leave start box in cocaine runway0.60.71.31.1-0.9-0.91.2-0.6-0.60.6-0.4
Latency to leave start box in cocaine runway, F0.10.10.50.5-0.1-0.10.70.20.2-0.20.5
Latency to leave start box in cocaine runway, M2.01.92.31.2-1.3-1.31.0-1.5-1.51.5-1.5
Std. dev. time between licks in bursts0.71.01.61.1-1.0-1.01.3-0.8-0.80.8-0.8
Total sessions with >9 infusions0.30.40.80.1-0.4-0.50.3-0.9-0.80.8-0.6
Short access day 1 total inactive lever presses0.40.51.20.5-0.6-0.61.1-0.8-0.70.7-0.7
Short access day 10 total inactive lever presses0.00.10.4-0.30.10.0-0.1-0.3-0.60.6-0.3
Short access day 1 total infusions0.30.40.60.5-0.6-0.60.7-0.7-0.60.6-0.6
Short access day 10 total infusions0.10.10.3-0.1-0.1-0.20.2-0.5-0.50.5-0.2
Short access total infusions0.30.40.80.3-0.5-0.60.8-0.9-0.80.8-0.5
Short access day 1 locomotion1.41.72.41.0-1.3-1.30.9-1.5-1.51.5-1.3
Short access day 10 total locomotion4.48.210.92.2-2.7-2.82.4-3.3-3.23.2-3.0
Short access total locomotion2.53.04.31.3-1.6-1.71.1-2.1-2.02.0-1.7
One hour access (0.3 mA shock)0.00.00.1-0.30.20.10.4-0.1-0.00.00.1
Compulsive drug intake1.01.21.9-0.60.91.0-0.61.31.4-1.41.4
One hour access (shock baseline)0.40.60.90.3-0.6-0.60.8-1.0-0.90.9-0.8
Social response proportion1.01.23.11.3-1.1-1.01.7-0.7-0.80.8-0.8
Social responses7.49.511.13.3-3.2-3.23.2-2.9-3.03.0-2.9
Social time0.40.50.6-0.60.70.8-0.70.80.7-0.70.7
Soleus weight8.926.327.5-5.15.25.2-5.25.05.1-5.15.0
Bone: stiffness2.84.65.1-1.92.12.1-1.92.32.3-2.32.3
Tibialis anterior weight1.13.84.5-2.02.02.0-2.12.01.7-1.72.0
Time to tail flick, vehicle, before self-admin0.10.10.30.4-0.3-0.3-0.5-0.2-0.30.2-0.2
Time to tail flick, vehicle, after self-admin0.20.30.60.1-0.4-0.4-0.2-0.7-0.80.7-0.7
Time to tail flick, test, before self-admin0.30.30.60.7-0.6-0.60.7-0.4-0.10.2-0.5
Time to tail flick, test, after self-admin0.10.10.10.3-0.3-0.3-0.3-0.2-0.10.3-0.3
Delta time to tail flick, vehicle, before/after SA0.20.20.7-0.90.60.5-0.50.20.2-0.20.3
Delta time to tail flick, test, before/after SA0.10.10.4-0.30.10.1-0.7-0.1-0.20.3-0.2
Tibia length0.92.52.71.5-1.5-1.61.6-1.6-1.61.6-1.6
Ambulatory time before self-admin0.10.10.4-0.30.30.3-0.30.30.2-0.20.6
Ambulatory time after self-admin0.00.00.00.1-0.0-0.1-0.10.0-0.10.10.0
Bone: tissue strength1.81.82.2-1.21.41.4-1.01.51.5-1.51.5
Total heroin consumption1.61.92.31.5-1.5-1.41.1-1.3-1.51.3-1.3
Bone: trabecular number0.30.61.21.1-0.9-0.81.1-0.4-0.40.4-0.4
Bone: trabecular spacing0.50.72.3-1.30.90.8-1.50.10.1-0.10.1
Bone: trabecular thickness0.40.51.20.8-0.1-0.11.10.70.7-0.70.7
Bone: trabecular tissue density1.21.82.1-1.41.41.5-1.31.31.3-1.31.3
Water consumed over 24 hours0.81.11.6-0.81.00.9-1.31.11.1-1.11.1
Number of responses in last shaping day1.61.82.80.9-1.2-1.30.7-1.7-1.61.6-1.4