Retn

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Retn	0.18	0.08	9.1e-08	0.09	0.1	0.09	0.1	1.5e-07	4.3e-08	1.8e-07	4.6e-08
2	Adipose	gene expression	Retn	0.32	0.12	0.0e+00	0.15	0.17	0.18	0.19	1.3e-16	8.9e-19	1.2e-19	1.8e-20
3	Adipose	isoform ratio	NM_144741.1	0.13	0.06	1.2e-11	0.07	0.08	0.09	0.08	1.2e-08	1.3e-09	9.8e-10	1.7e-09
4	Adipose	isoform ratio	XM_063271045.1	0.14	0.06	4.7e-12	0.08	0.09	0.09	0.08	8.8e-09	6.7e-10	5.7e-10	1.2e-09
5	Adipose	alternative polyA	NM_144741.1	0.15	0.07	2.4e-13	0.07	0.1	0.1	0.1	6.2e-08	2.0e-11	5.3e-11	4.0e-11
6	Adipose	alternative polyA	XM_063271045.1	0.14	0.06	3.2e-13	0.07	0.1	0.1	0.1	8.2e-08	2.1e-11	5.6e-11	5.5e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.0	1.8	6.0	-2.1	2.5	-0.2	0.1	0.4	-0.4
Area under the delay curve	2.1	2.4	5.5	-0.0	-2.3	-1.3	1.3	-1.7	1.7
BMI with tail	0.7	2.4	7.5	-2.7	1.3	-1.4	1.4	-0.9	0.9
BMI without tail	2.4	7.3	17.1	-4.1	0.5	-2.9	2.8	-2.3	2.3
Body weight	6.6	28.9	75.1	-8.7	2.1	-5.6	5.5	-4.0	4.0
Weight adjusted by age	0.3	0.4	1.5	-0.7	1.2	-0.1	-0.0	0.4	-0.4
Bone surface	1.4	2.6	8.5	-2.9	1.7	-1.4	1.3	-0.7	0.7
Bone volume	0.7	1.3	3.8	-1.9	1.9	-0.5	0.4	0.0	-0.0
Breakpoint value in progressive ratio session	1.3	1.5	1.9	-0.8	-1.3	-1.2	1.3	-1.4	1.4
Number of licking bursts	0.4	0.6	1.8	-0.2	1.3	0.4	-0.4	0.8	-0.8
Context. condit. distance diff. score	3.5	4.2	7.3	-2.7	-0.6	-2.2	2.2	-2.0	2.0
Locomotion velocity, session 1	0.3	0.3	1.1	0.4	-1.1	-0.4	0.4	-0.5	0.5
Locomotion distance, session 1	0.4	0.5	1.6	1.3	-0.9	0.5	-0.4	0.2	-0.2
Locomotion velocity, session 2	0.2	0.2	0.8	0.3	-0.9	-0.3	0.4	-0.4	0.4
Locomotion distance, session 2	0.5	0.7	2.3	1.5	-0.8	0.7	-0.7	0.4	-0.4
Locomotion velocity, session 3	0.4	0.4	0.5	-0.7	-0.4	-0.7	0.7	-0.7	0.7
Locomotion distance, session 3	0.5	0.5	0.7	0.5	0.6	0.8	-0.8	0.8	-0.8
Stereotopy head waving bouts, day 3	0.6	0.7	2.3	-1.5	1.4	-0.2	0.2	0.0	-0.0
Stereotopy head waving duration, day 3	0.1	0.2	0.3	0.1	0.5	0.4	-0.4	0.4	-0.4
Locomotion velocity, session 7	1.8	1.9	4.1	-0.1	-2.0	-1.2	1.3	-1.5	1.5
Locomotion distance, session 7	0.8	1.1	2.6	-0.1	-1.6	-0.8	0.8	-1.1	1.1
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.4	-0.5	0.1	-0.1	-0.1	0.1
Stereotopy head waving duration, day 7	0.2	0.2	0.6	0.8	-0.5	0.3	-0.2	0.1	-0.1
Locomotion velocity, session 8	0.7	0.9	1.1	-0.7	-0.9	-1.1	1.1	-1.0	1.0
Locomotion distance, session 8	1.4	2.0	2.7	-1.6	-0.7	-1.6	1.6	-1.4	1.4
Degree of sensitization distance	0.7	0.8	2.5	0.5	-1.6	-0.5	0.5	-0.8	0.8
Degree of sensitization stereotypy	0.1	0.2	0.6	0.5	-0.8	-0.1	0.1	-0.2	0.2
Conditioned locomotion	0.6	0.7	0.8	0.3	0.9	0.9	-0.9	0.9	-0.9
Cocaine response after cond. corrected	0.2	0.2	0.9	-0.1	0.9	0.2	-0.2	0.4	-0.4
Cocaine response after cond. not corrected	0.1	0.1	0.2	-0.4	0.2	-0.3	0.3	-0.3	0.3
Cocaine response before conditioning	1.3	1.6	2.0	-0.8	-1.4	-1.2	1.2	-1.4	1.4
Saline control response	0.5	0.7	2.6	-1.6	0.7	-0.6	0.6	-0.3	0.3
Bone: connectivity density	1.7	2.6	8.9	-3.0	1.9	-1.2	1.2	-0.5	0.5
Bone: cortical apparent density	0.3	0.3	1.0	0.2	-1.0	-0.4	0.4	-0.6	0.6
Bone: cortical area	3.1	4.8	6.3	-2.5	-0.9	-2.4	2.4	-2.2	2.2
Bone: cortical porosity	0.1	0.1	0.3	0.1	0.5	0.4	-0.4	0.4	-0.4
Bone: cortical porosity	0.1	0.1	0.1	0.4	-0.1	0.3	-0.3	0.2	-0.2
Bone: cortical thickness	2.0	3.3	5.2	-2.3	-0.6	-2.0	2.0	-1.8	1.8
Bone: cortical thickness	1.2	1.4	2.3	-1.5	-0.4	-1.3	1.3	-1.2	1.2
Bone: cortical tissue density	0.2	0.2	0.7	0.4	-0.9	-0.2	0.3	-0.4	0.4
Condit. Reinf. active minus inactive responses	0.2	0.2	0.8	0.5	-0.9	-0.1	0.1	-0.4	0.4
Condit. Reinf. active-inactive response ratio	0.4	0.5	1.0	-0.1	-1.0	-0.6	0.6	-0.8	0.8
Condit. Reinf. active responses	0.2	0.3	1.0	0.5	-1.0	-0.1	0.1	-0.4	0.4
Condit. Reinf. inactive responses	0.2	0.3	0.8	0.9	-0.9	0.3	-0.3	-0.0	0.0
Incentive salience index mean	0.2	0.2	0.8	0.6	-0.9	0.1	-0.1	-0.3	0.3
Condit. Reinf. lever presses	0.1	0.1	0.5	0.6	-0.7	0.2	-0.2	-0.1	0.1
Condit. Reinf. active minus inactive responses	3.0	3.9	4.8	-1.7	-1.4	-2.2	2.2	-2.1	2.1
Condit. Reinf. active-inactive response ratio	2.2	2.5	3.1	-1.0	-1.5	-1.7	1.8	-1.7	1.7
Condit. Reinf. active responses	3.3	4.6	5.5	-2.0	-1.5	-2.3	2.3	-2.3	2.3
Condit. Reinf. inactive responses	0.4	0.5	1.1	-1.0	-0.3	-0.7	0.7	-0.7	0.7
Condit. Reinf. lever presses	0.6	0.9	1.1	-0.8	-0.8	-0.9	1.0	-1.1	1.1
Condit. Reinf. lever reinforcers received	2.9	4.0	4.7	-1.7	-1.7	-2.1	2.2	-2.2	2.2
Conditioned reinforcement - actives	1.2	2.0	5.1	-2.3	0.4	-1.5	1.5	-1.1	1.1
Conditioned reinforcement - inactives	0.3	0.5	1.4	-0.1	1.2	0.5	-0.5	0.7	-0.7
Conditioned locomotion	1.3	1.7	3.7	-1.9	-0.1	-1.4	1.3	-1.2	1.2
Patch foraging indifference point 0 sec	1.8	3.3	4.4	0.8	2.1	1.8	-1.8	2.0	-2.0
Patch foraging indifference point AUC	0.3	0.4	1.2	-1.1	0.8	-0.4	0.4	-0.0	0.0
Delay disc. indifference point, 0s delay	4.0	4.4	5.3	-1.5	-1.8	-2.3	2.3	-2.3	2.3
Delay disc. indifference point, 16s delay	0.5	0.6	1.3	0.1	-1.1	-0.7	0.7	-0.8	0.8
Delay disc. indifference point, 2s delay	2.9	3.2	8.4	0.2	-2.9	-1.4	1.4	-1.9	1.9
Delay disc. indifference point, 24s delay	0.3	0.3	1.2	0.6	-1.1	-0.2	0.2	-0.4	0.4
Delay disc. indifference point, 4s delay	1.6	1.7	3.8	0.0	-2.0	-1.1	1.1	-1.4	1.4
Delay disc. indifference point, 8s delay	0.7	0.8	2.1	0.1	-1.4	-0.7	0.7	-0.9	0.9
Indifference point function ln k	0.1	0.1	0.2	0.4	0.2	0.5	-0.4	0.3	-0.3
Indifference point function log k	0.1	0.1	0.2	0.4	0.2	0.5	-0.4	0.3	-0.3
Patch foraging total patch changes 0 sec	2.4	4.5	5.7	1.0	2.4	2.2	-2.2	2.4	-2.4
Patch foraging total patch changes 12 sec	0.9	1.2	3.2	-0.2	1.8	0.8	-0.8	1.1	-1.1
Patch foraging total patch changes 18 sec	2.0	3.1	5.4	0.5	2.3	1.6	-1.6	2.0	-2.0
Patch foraging total patch changes 24 sec	1.2	2.1	2.5	0.7	1.5	1.5	-1.5	1.6	-1.6
Patch foraging total patch changes 6 sec	1.6	2.4	4.7	0.3	2.2	1.4	-1.4	1.7	-1.7
Patch foraging time to switch 0 sec	0.2	0.4	1.1	0.6	-1.1	-0.3	0.3	-0.6	0.6
Patch foraging water rate 0 sec	0.7	1.4	4.5	-0.9	2.1	0.7	-0.7	1.1	-1.1
Patch foraging water rate 12 sec	0.0	0.1	0.1	-0.0	0.4	0.3	-0.3	0.2	-0.2
Patch foraging water rate 18 sec	0.2	0.3	1.1	0.2	-1.0	-0.3	0.3	-0.6	0.6
Patch foraging water rate 24 sec	0.3	0.4	1.4	-1.2	0.7	-0.3	0.3	-0.1	0.1
Patch foraging water rate 6 sec	0.1	0.1	0.4	-0.3	0.6	0.3	-0.3	0.3	-0.3
Seeking ratio, delayed vs. immediate footshock	3.2	4.0	4.7	2.2	1.1	2.1	-2.1	2.1	-2.1
Distance traveled before self-admin	0.3	0.4	1.3	0.8	-1.2	0.1	-0.0	-0.4	0.4
Distance traveled after self-admin	0.1	0.1	0.6	0.2	-0.8	-0.1	0.1	-0.3	0.3
Extensor digitorum longus weight	2.9	11.4	28.1	-5.3	0.5	-3.5	3.4	-2.8	2.8
Bone: elastic displacement	0.1	0.1	0.3	-0.5	0.4	-0.2	0.2	-0.0	0.0
Bone: elastic work	1.2	1.6	5.0	-2.2	1.1	-1.1	1.1	-0.6	0.6
Bone: endosteal estimation	0.3	0.6	2.3	-0.9	1.5	0.1	-0.2	0.5	-0.5
Bone: endosteal perimeter	0.3	0.6	1.8	-1.3	0.2	-0.8	0.8	-0.6	0.6
Epididymis fat weight	0.0	0.1	0.1	-0.2	-0.3	-0.2	0.2	-0.3	0.3
Delta time in closed arm before/after self-admin	1.2	1.1	1.7	-0.6	-1.3	-1.1	1.1	-1.1	1.1
Delta time in open arm before/after self-admin	1.1	1.1	2.8	1.7	-0.1	1.2	-1.2	0.8	-0.8
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	-0.5	-0.0	-0.4	0.4	-0.3	0.3
Delay discount exponential model param	2.3	2.5	6.4	-0.2	2.5	1.2	-1.3	1.7	-1.7
Extinction: sum of active levers before priming	0.3	0.3	0.6	0.0	-0.8	-0.4	0.4	-0.6	0.6
Active lever presses in extinction session 6	0.0	0.0	0.1	-0.3	0.4	0.0	-0.0	0.0	-0.0
Bone: final force	1.9	3.0	6.0	-2.5	0.0	-2.0	1.9	-1.4	1.4
Bone: final moment	1.4	2.2	4.6	-2.2	0.1	-1.7	1.7	-1.2	1.2
Food consumed during 24 hour testing period	0.6	0.8	2.1	0.1	1.4	0.7	-0.7	0.9	-0.9
Glucose	0.4	0.6	2.0	1.0	-1.4	-0.0	0.1	-0.4	0.4
Heart weight	0.4	0.6	0.8	-0.6	-0.8	-0.8	0.8	-0.9	0.9
Delay discount hyperbolic model param	2.2	2.5	6.0	-0.1	2.5	1.3	-1.3	1.7	-1.7
Intermittent access intake day 1-15 change	0.3	0.7	2.8	-0.8	1.7	0.2	-0.2	0.7	-0.7
Intermittent access intake escalation	0.3	0.7	2.7	-0.7	1.6	0.2	-0.3	0.7	-0.7
Intermittent access intake escalation 2	0.5	0.6	1.2	0.2	1.1	0.6	-0.6	0.8	-0.8
Intermitt. access day 1 inactive lever presses	0.2	0.8	1.7	0.2	1.3	0.8	-0.8	0.9	-0.9
Intermitt. access day 15 inactive lever presses	0.4	0.7	1.5	0.3	1.2	0.7	-0.7	0.9	-0.9
Intermitt. access escalation Index	0.1	0.2	0.8	0.4	-0.9	-0.0	0.0	-0.3	0.3
Intermittent access day 1 total infusions	0.3	0.5	2.1	0.6	-1.4	-0.1	0.2	-0.6	0.6
Intermittent access day 15 total infusions	0.0	0.0	0.1	-0.1	-0.3	-0.1	0.1	-0.2	0.2
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	-0.0	-0.4	-0.1	0.1	-0.2	0.2
Intermittent access total infusions	0.5	0.6	1.3	-0.1	-1.1	-0.6	0.6	-0.8	0.9
Intermittent access day 1 locomotion	0.5	0.7	2.6	0.6	-1.6	-0.2	0.2	-0.7	0.7
Intermittent access day 15 total locomotion	0.1	0.1	0.3	-0.1	-0.6	-0.1	0.1	-0.3	0.3
Intermittent access total locomotion	0.4	0.5	1.6	0.3	-1.3	-0.3	0.3	-0.7	0.7
Intermittent access standard deviation	0.6	1.2	3.1	0.1	1.8	0.8	-0.9	1.2	-1.2
Left kidney weight	3.1	14.6	45.4	-6.7	2.9	-3.6	3.5	-2.1	2.1
Right kidney weight	2.8	12.7	38.4	-6.2	2.6	-3.4	3.3	-2.0	2.0
Cocaine induced anxiety	0.6	0.9	1.4	-0.3	-1.2	-0.8	0.9	-1.1	1.1
Post-drug Anxiety	2.1	2.2	5.6	0.5	-2.4	-1.2	1.2	-1.5	1.5
Baseline Anxiety	0.4	0.4	1.2	1.1	-1.1	-0.1	0.2	-0.2	0.2
Tail length	4.8	18.8	44.6	-6.7	0.8	-4.7	4.6	-3.5	3.5
Length with tail	8.1	35.3	90.1	-9.5	1.9	-6.3	6.2	-4.5	4.5
Length without tail	3.6	11.5	35.7	-6.0	3.0	-3.1	3.0	-1.6	1.6
Times rat made contact with spout	0.9	1.0	1.5	-1.2	-0.2	-1.1	1.1	-1.0	1.0
Lifetime Intake	0.3	0.3	1.0	0.2	-1.0	-0.3	0.3	-0.6	0.6
Liver weight, left	1.8	2.9	10.6	-1.6	3.3	0.6	-0.7	1.3	-1.3
Liver weight, right	0.7	1.3	4.3	-2.1	1.4	-0.8	0.7	-0.3	0.3
Locomotor activity	1.6	2.5	3.7	-1.9	-0.9	-1.7	1.7	-1.5	1.5
Locomotor testing distance	0.1	0.2	0.6	-0.8	0.6	-0.1	0.1	0.2	-0.2
Locomotor testing rearing	0.6	1.1	1.5	0.5	1.1	1.1	-1.1	1.2	-1.2
Locomotion in novel chamber	0.0	0.1	0.3	-0.6	0.2	-0.1	0.1	-0.1	0.1
Locomotion in novel chamber post-restriction	0.8	1.2	2.1	-1.4	-0.5	-1.2	1.2	-1.1	1.1
Fecal boli incidents, locomotor time 1	1.1	1.5	3.1	-1.8	-0.1	-1.3	1.3	-1.2	1.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	0.3	0.3	0.3	-0.3	0.4	-0.4
Time >=10cm from walls, locomotor time 1	0.7	0.7	2.2	0.4	-1.5	-0.5	0.5	-0.8	0.8
Bouts of movement, locomotor time 1	0.5	0.6	1.6	-1.3	0.4	-0.8	0.8	-0.6	0.6
Total resting periods, locomotor time 1	0.6	0.7	1.7	-1.3	0.2	-0.9	0.9	-0.7	0.7
Rest time, locomotor task time 1	0.8	1.1	2.6	-1.6	0.4	-1.0	1.0	-0.8	0.8
Distance moved, locomotor task time 1	0.2	0.3	1.2	0.7	-1.1	0.0	0.0	-0.2	0.2
Vertical activity count, locomotor time 1	0.1	0.2	0.5	-0.1	-0.7	-0.3	0.3	-0.4	0.4
Time >=10cm from walls, locomotor time 2	1.5	2.2	2.7	-1.4	-1.0	-1.6	1.6	-1.6	1.6
Bouts of movement, locomotor time 2	0.3	0.5	1.5	-1.2	0.3	-0.6	0.6	-0.6	0.6
Total resting periods, locomotor time 2	0.2	0.4	1.3	-1.1	0.6	-0.4	0.4	-0.3	0.3
Rest time, locomotor task time 2	0.0	0.0	0.1	0.3	-0.0	0.2	-0.2	0.1	-0.1
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.0	0.2	0.1	-0.2	0.3	-0.3
Vertical activity count, locomotor time 2	0.3	0.4	1.4	-1.2	0.7	-0.4	0.4	-0.1	0.1
Light reinforcement 1	0.6	1.6	4.5	0.4	-2.1	-0.9	0.9	-1.3	1.3
Light reinforcement 2	0.2	0.3	0.5	0.7	0.2	0.6	-0.6	0.6	-0.6
Bone: marrow area	0.3	0.7	2.5	-0.8	1.6	0.2	-0.2	0.6	-0.6
Bone: maximum diameter	0.8	1.4	3.7	-1.9	0.5	-1.3	1.2	-0.9	0.9
Bone: maximum force	1.1	2.0	4.8	-2.2	0.3	-1.5	1.5	-1.1	1.1
Bone: maximum moment	0.8	1.4	3.7	-1.9	0.4	-1.3	1.2	-0.9	0.9
Mean time between licks in bursts	0.7	1.7	3.6	1.9	-0.1	1.4	-1.4	1.1	-1.1
Mean num. licks in bursts	0.3	0.5	0.6	-0.4	-0.8	-0.6	0.6	-0.8	0.8
Cd content in liver	0.4	0.5	1.4	0.1	-1.2	-0.5	0.5	-0.6	0.7
Co content in liver	2.5	2.9	5.0	0.5	2.2	1.5	-1.6	1.9	-1.9
Cu content in liver	0.1	0.2	0.2	0.4	0.2	0.4	-0.4	0.4	-0.4
Fe content in liver	0.9	1.1	1.4	-1.1	-0.8	-1.0	1.0	-1.2	1.2
K content in liver	0.2	0.2	0.3	-0.4	-0.2	-0.5	0.6	-0.5	0.5
Mg content in liver	0.2	0.2	0.6	-0.8	0.5	-0.5	0.4	-0.2	0.2
Mn content in liver	0.3	0.4	0.5	0.6	0.5	0.6	-0.6	0.7	-0.7
Na content in liver	0.5	0.6	1.2	-1.1	0.1	-0.8	0.8	-0.6	0.6
Rb content in liver	0.9	1.0	3.3	1.8	-1.0	0.9	-0.9	0.4	-0.4
Se content in liver	3.6	4.3	5.1	-2.0	-1.4	-2.2	2.2	-2.2	2.2
Sr content in liver	0.7	0.6	1.5	-0.0	1.2	0.5	-0.6	0.9	-0.9
Zn content in liver	1.1	1.2	4.4	-1.6	2.1	-0.1	0.1	0.5	-0.5
Bone: minimum diameter	0.0	0.0	0.0	0.1	-0.0	0.0	-0.0	0.0	-0.0
Time in familiar zone, hab. session 1	2.0	1.9	2.2	1.0	1.3	1.4	-1.5	1.5	-1.5
Time in novel zone, hab. session 1	1.3	1.3	1.6	-1.1	-0.7	-1.3	1.3	-1.2	1.2
Total zone transitions, hab. session 1	0.5	0.7	2.4	1.2	-1.6	0.1	-0.1	-0.3	0.3
Total locomotion distance, hab. session 1	0.3	0.5	1.8	0.5	-1.3	-0.3	0.3	-0.6	0.6
Locomotion velocity, hab. session 1	0.5	0.8	2.9	1.0	-1.7	-0.1	0.1	-0.6	0.6
Time in familiar zone, hab. session 2	0.0	0.0	0.1	0.1	0.2	0.1	-0.2	0.2	-0.2
Time in novel zone, hab. session 2	0.1	0.1	0.5	0.3	-0.7	-0.1	0.2	-0.2	0.2
Total zone transitions, hab. session 2	0.1	0.1	0.1	-0.2	-0.3	-0.4	0.4	-0.3	0.3
Total locomotion distance, hab. session 2	0.1	0.1	0.4	0.4	-0.6	-0.0	0.0	-0.2	0.2
Locomotion velocity, hab. session 2	0.1	0.1	0.3	0.5	-0.6	0.0	-0.0	-0.1	0.1
Novel to familiar place preference ratio	0.1	0.1	0.2	0.1	-0.4	-0.2	0.2	-0.2	0.2
Novelty place preference	0.1	0.1	0.3	0.4	-0.5	-0.0	0.0	-0.1	0.1
Time in novel zone, NPP test	0.1	0.1	0.2	0.2	-0.5	-0.2	0.2	-0.2	0.2
Total zone transitions, NPP test	0.2	0.3	0.4	-0.2	-0.6	-0.5	0.5	-0.5	0.5
Total locomotion distance, NPP test	1.0	1.4	2.5	-0.3	-1.6	-1.1	1.1	-1.3	1.3
Locomotion velocity, NPP test	0.9	1.3	2.4	-0.4	-1.6	-1.0	1.1	-1.3	1.3
Intraocular pressure	0.4	0.5	2.0	-1.4	0.8	-0.5	0.5	-0.3	0.3
Delta distance traveled before/after self-admin	0.2	0.2	0.6	-0.2	0.8	0.3	-0.3	0.5	-0.5
Delta ambulatory time before/after self-admin	0.4	0.5	0.7	0.6	0.5	0.8	-0.8	0.8	-0.8
Parametrial fat weight	0.0	0.1	0.3	-0.5	0.3	-0.3	0.3	-0.2	0.2
Pavlov. Cond. lever latency	0.7	0.8	2.4	-1.6	1.4	-0.6	0.6	-0.0	0.0
Pavlov. Cond. magazine entry latency	0.6	0.8	0.9	-0.9	-0.7	-0.9	0.9	-0.9	0.9
Pavlov. Cond. change in total contacts	1.1	1.2	2.6	-0.1	-1.6	-0.9	0.9	-1.2	1.2
Pavlov. Cond. index score	0.3	0.4	1.1	-0.0	-1.0	-0.5	0.5	-0.7	0.7
Pavlov. Cond. latency score	0.4	0.5	1.7	0.2	-1.3	-0.5	0.4	-0.8	0.8
Pavlov. Cond. lever contacts	0.5	0.6	1.8	1.2	-1.3	0.3	-0.3	-0.2	0.2
Pavlov. Cond. magazine entry number	0.8	1.0	1.2	0.9	0.9	1.0	-1.0	1.1	-1.1
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.9	1.4	0.1	1.1	-1.0	0.9	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.8	-0.1	-0.9	-0.5	0.5	-0.7	0.7
Pavlov. Cond. response bias	0.5	0.6	0.8	-0.5	-0.9	-0.8	0.7	-0.9	0.9
Pavlov. Cond. lever latency	1.0	1.4	2.4	0.3	1.6	1.1	-1.1	1.3	-1.3
Pavlov. Cond. magazine entry latency	1.4	1.7	5.2	0.5	-2.3	-0.9	0.9	-1.3	1.3
Pavlov. Cond. change in total contacts	0.5	0.8	2.0	0.1	-1.4	-0.7	0.7	-0.9	0.9
Pavlov. Cond. index score	1.0	1.4	4.1	0.3	-2.0	-0.8	0.9	-1.2	1.2
Pavlov. Cond. latency score	1.1	1.4	3.9	0.3	-2.0	-0.8	0.9	-1.2	1.2
Pavlov. Cond. lever contacts	1.3	1.8	3.2	-0.3	-1.8	-1.2	1.2	-1.5	1.5
Pavlov. Cond. magazine entry number	0.9	1.1	3.9	-0.8	2.0	0.5	-0.6	0.9	-1.0
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.7	-0.9	0.5	-0.3	0.3	-0.1	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.6	4.7	0.4	-2.2	-0.9	0.9	-1.3	1.3
Pavlov. Cond. response bias	1.6	2.2	5.5	0.1	-2.3	-1.2	1.2	-1.6	1.6
Time in closed arm before self-admin	0.4	0.5	1.2	-1.1	1.1	-0.4	0.4	-0.0	0.0
Time in closed arm after self-admin	0.5	0.5	1.1	-1.1	-0.2	-0.8	0.8	-0.6	0.6
Time in open arm before self-admin	0.6	0.6	1.6	-0.2	-1.3	-0.6	0.6	-0.8	0.8
Time in open arm after self-admin	0.2	0.2	0.6	0.8	-0.5	0.4	-0.4	0.1	-0.1
Bone: periosteal estimation	0.8	1.8	4.4	-2.1	0.4	-1.4	1.4	-1.0	1.0
Bone: periosteal perimeter	1.3	2.3	2.6	-1.6	-0.9	-1.6	1.6	-1.6	1.6
Bone: post-yield work	0.0	0.0	0.2	-0.4	0.2	-0.1	0.1	-0.0	0.0
Progressive ratio test 1 active lever presses	0.7	0.8	1.5	-1.2	-0.1	-1.0	1.0	-0.8	0.8
Progressive ratio test 1 breakpoint	0.7	0.9	1.6	-1.3	-0.2	-1.0	1.0	-0.9	0.9
Progressive ratio test 1 inactive lever presses	0.3	0.4	1.1	-0.3	1.1	0.4	-0.4	0.6	-0.6
Progressive ratio test 2 active lever presses	0.3	0.3	0.7	-0.9	0.0	-0.6	0.6	-0.5	0.5
Progressive ratio test 2 breakpoint	0.3	0.3	0.6	-0.8	-0.0	-0.6	0.6	-0.5	0.5
Progressive ratio test 2 inactive lever presses	0.4	0.7	2.6	-1.2	1.6	0.0	-0.1	0.4	-0.4
Incentive Sensitization - Responses	0.0	0.0	0.1	0.3	0.1	0.2	-0.2	0.2	-0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	0.4	0.1	0.3	-0.3	0.3	-0.3
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	-0.5	-0.0	-0.5	0.5	-0.4	0.4
Progressive ratio	0.4	0.6	1.3	1.1	-0.1	0.9	-0.9	0.6	-0.6
Food seeking constrained by brief footshock	4.2	5.2	6.2	1.9	1.8	2.5	-2.5	2.4	-2.4
Seeking ratio, punishment vs. effort	0.2	0.3	0.9	-0.7	1.0	-0.1	0.1	0.2	-0.2
Retroperitoneal fat weight	0.3	1.2	1.4	-0.7	-1.0	-1.2	1.2	-1.2	1.2
Reaction time number correct	0.3	0.7	2.0	-0.2	1.4	0.5	-0.5	0.8	-0.8
Reaction time mean minus median	3.1	7.7	9.7	-1.6	-3.1	-2.8	2.8	-3.1	3.1
Reaction time mean minus median AUC	0.8	2.1	5.0	-0.1	-2.2	-1.2	1.2	-1.5	1.6
Reaction time num false alarms	0.8	1.1	2.8	-0.1	-1.7	-0.8	0.8	-1.2	1.2
Reaction time num false alarms AUC	0.4	0.7	1.6	-0.2	-1.3	-0.6	0.6	-0.9	0.9
Reaction time trials correct on left	0.3	0.7	2.0	-0.2	1.4	0.5	-0.5	0.8	-0.8
Reaction time trials on left	0.3	0.6	1.8	-0.2	1.3	0.5	-0.5	0.7	-0.7
Reaction time mean	1.4	2.2	7.3	0.9	-2.7	-0.8	0.8	-1.4	1.4
Reaction time mean AUC	1.2	2.0	7.1	1.0	-2.7	-0.6	0.7	-1.2	1.2
Median of all reaction times	0.9	1.3	4.3	1.7	-2.1	0.1	-0.1	-0.5	0.5
Reaction time omissions	0.7	1.1	2.9	0.3	-1.7	-0.7	0.7	-1.1	1.1
Reaction time false alarm rate	1.1	1.5	3.7	-0.2	-1.9	-0.9	0.9	-1.4	1.4
Reaction time premature initiation rate	0.8	1.1	1.9	-0.4	-1.4	-0.9	0.9	-1.2	1.2
Reaction time premature initiations	0.2	0.3	0.4	-0.4	-0.6	-0.5	0.5	-0.6	0.6
Std. dev. reaction times	2.3	4.2	8.3	-0.4	-2.9	-1.8	1.8	-2.2	2.2
Reaction time trials completed	0.3	0.6	1.8	-0.2	1.3	0.5	-0.5	0.7	-0.7
Reaction time trials AUC	0.3	0.6	1.6	-0.0	1.2	0.6	-0.6	0.8	-0.8
Run reversals in cocaine runway, females	0.6	0.6	1.0	1.0	0.3	0.9	-0.8	0.7	-0.7
Run reversals in cocaine runway, males	0.5	0.5	0.6	0.7	0.3	0.8	-0.7	0.7	-0.7
Latency to leave start box in cocaine runway	0.1	0.1	0.1	-0.1	-0.3	-0.4	0.4	-0.3	0.3
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	-0.5	0.3	-0.5	0.4	-0.1	0.1
Latency to leave start box in cocaine runway, M	0.1	0.1	0.4	0.4	-0.6	0.1	-0.1	-0.2	0.2
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.3	-0.5	-0.3	0.3	-0.4	0.4
Total sessions with >9 infusions	0.1	0.1	0.2	0.5	0.0	0.4	-0.4	0.3	-0.3
Short access day 1 total inactive lever presses	0.6	0.8	1.8	0.1	1.3	0.8	-0.8	1.0	-1.0
Short access day 10 total inactive lever presses	1.0	2.5	8.7	-0.7	2.9	0.8	-0.9	1.5	-1.5
Short access day 1 total infusions	0.6	0.8	1.3	1.2	0.2	1.0	-1.0	0.8	-0.9
Short access day 10 total infusions	0.1	0.1	0.2	0.5	-0.2	0.4	-0.4	0.2	-0.2
Short access total infusions	0.1	0.2	0.6	0.7	-0.4	0.3	-0.4	0.2	-0.2
Short access day 1 locomotion	0.8	1.0	3.2	0.1	-1.8	-0.6	0.6	-1.0	1.0
Short access day 10 total locomotion	0.4	0.8	1.0	0.5	0.9	1.0	-1.0	1.0	-1.0
Short access total locomotion	0.2	0.2	0.8	0.6	-0.9	0.1	-0.1	-0.2	0.2
One hour access (0.3 mA shock)	0.1	0.2	0.5	-0.4	0.7	0.2	-0.2	0.4	-0.4
Compulsive drug intake	1.3	1.5	3.5	1.9	-0.2	1.3	-1.3	1.1	-1.1
One hour access (shock baseline)	1.0	1.5	2.6	-1.6	-0.4	-1.3	1.3	-1.2	1.2
Social response proportion	6.3	7.1	9.2	-3.0	-1.2	-3.0	3.0	-2.7	2.7
Social responses	1.4	1.8	3.1	-1.8	-0.5	-1.4	1.4	-1.3	1.3
Social time	0.7	1.0	3.1	1.5	-1.8	0.3	-0.3	-0.3	0.3
Soleus weight	0.4	1.2	4.3	-2.1	0.9	-0.9	0.9	-0.6	0.6
Bone: stiffness	1.1	1.9	2.2	-1.3	-1.0	-1.5	1.5	-1.4	1.4
Tibialis anterior weight	4.5	15.2	34.3	-5.9	0.3	-4.2	4.1	-3.4	3.4
Time to tail flick, vehicle, before self-admin	1.2	1.3	2.8	0.1	-1.7	-1.0	1.0	-1.2	1.2
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.6	-0.2	-0.8	-0.6	0.6	-0.6	0.6
Time to tail flick, test, before self-admin	0.6	0.6	1.6	-1.3	0.5	-0.8	0.8	-0.3	0.3
Time to tail flick, test, after self-admin	0.2	0.2	0.6	0.1	-0.8	-0.3	0.3	-0.4	0.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	0.3	0.2	0.4	-0.4	0.4	-0.4
Delta time to tail flick, test, before/after SA	0.6	0.6	1.5	1.2	-0.3	0.9	-0.9	0.5	-0.5
Tibia length	1.8	4.9	13.7	-3.7	1.5	-2.3	2.2	-1.3	1.3
Ambulatory time before self-admin	0.3	0.4	1.3	0.2	-1.1	-0.3	0.3	-0.7	0.7
Ambulatory time after self-admin	0.1	0.1	0.5	0.4	-0.7	0.0	-0.0	-0.2	0.2
Bone: tissue strength	2.0	2.0	3.1	0.6	1.8	1.4	-1.4	1.6	-1.6
Total heroin consumption	1.0	1.1	4.4	1.1	-2.1	-0.1	0.1	-0.7	0.7
Bone: trabecular number	0.9	1.5	5.0	-2.2	1.5	-0.9	0.8	-0.3	0.3
Bone: trabecular spacing	1.4	1.8	4.7	2.2	-0.5	1.4	-1.4	1.0	-1.0
Bone: trabecular thickness	1.5	1.9	6.0	-2.5	1.0	-1.3	1.2	-0.8	0.8
Bone: trabecular tissue density	5.4	8.0	9.8	-1.5	-3.1	-2.8	2.8	-3.1	3.1
Water consumed over 24 hours	0.6	0.8	2.1	-1.5	1.4	-0.5	0.4	0.0	-0.0
Number of responses in last shaping day	0.1	0.1	0.3	0.5	-0.3	0.2	-0.2	0.1	-0.1