Hub : Genes

Reep6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Reep6 0.21 0.14 3.5e-04 0.16 0.14 0.15 0.15 1.3e-04 3.8e-04 2.3e-04 2.1e-04
2 pVTA gene expression Reep6 0.06 0.05 7.1e-04 0.01 0.02 0.02 0.02 4.1e-02 1.7e-02 1.5e-02 1.2e-02
3 Brain gene expression Reep6 0.1 0.08 6.2e-08 0.06 0.07 0.06 0.07 2.0e-06 6.0e-07 1.1e-06 5.8e-07
4 pVTA intron excision ratio chr7_10027938_10031130 0.05 0.04 6.6e-03 0.02 0.03 0.02 0.02 1.2e-02 2.9e-03 7.3e-03 4.5e-03
5 pVTA intron excision ratio chr7_10033620_10037762 0.17 0.1 4.3e-10 0.13 0.13 0.13 0.13 2.0e-10 2.6e-10 2.3e-10 2.7e-10
6 NAcc gene expression Reep6 0.04 0.03 7.5e-07 0.03 0.04 0.03 0.04 5.7e-06 7.6e-07 1.1e-05 1.0e-06
7 NAcc mRNA stability Reep6 0.02 0.02 1.8e-04 0.01 0.01 0.02 0.01 5.2e-03 2.6e-03 1.5e-03 6.7e-03
8 Eye mRNA stability Reep6 0.31 0.18 1.1e-03 0.12 0.1 0.13 0.12 7.4e-03 1.1e-02 5.5e-03 6.8e-03
9 Liver mRNA stability Reep6 0.02 0.02 1.7e-03 0.02 0.02 0.01 0.02 2.2e-03 4.6e-03 1.9e-02 5.0e-03
10 PL gene expression Reep6 0.03 0.02 2.3e-04 0.03 0.03 0.03 0.02 2.9e-04 5.8e-04 6.8e-04 1.0e-03
11 IC gene expression Reep6 0.15 0.1 8.9e-06 0.08 0.09 0.09 0.09 3.4e-04 1.2e-04 1.7e-04 1.9e-04
12 BLA intron excision ratio chr7_10027753_10027845 0.05 0.04 1.4e-03 0.03 0.04 0.03 0.03 1.7e-02 2.9e-03 1.3e-02 8.3e-03
13 NAcc intron excision ratio chr7_10027753_10027845 0.01 0.01 3.3e-03 0.01 0.01 0.01 0.01 3.6e-03 1.2e-02 3.8e-02 1.5e-02
14 BLA gene expression Reep6 0.05 0.04 7.6e-03 0.02 0.03 0.02 0.01 2.2e-02 1.8e-02 2.4e-02 5.2e-02
15 Liver gene expression Reep6 0.44 0.17 0.0e+00 0.34 0.38 0.38 0.38 4.5e-39 4.5e-44 5.8e-44 7.5e-44

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.40.72.5-0.8-0.80.1-1.50.8-0.1-0.00.40.70.70.40.50.71.31.6
Area under the delay curve2.12.42.91.61.61.61.2-1.41.71.61.71.71.71.71.71.41.41.4
BMI with tail6.321.625.64.94.84.94.0-5.14.94.94.84.64.64.84.74.74.13.6
BMI without tail2.06.18.12.82.82.62.6-2.82.72.72.42.32.32.52.52.41.81.5
Body weight0.94.04.62.12.02.11.7-2.12.12.12.02.02.02.12.02.11.81.6
Weight adjusted by age0.40.61.61.21.10.91.3-0.80.80.70.40.30.30.60.60.60.10.0
Bone surface0.91.67.7-1.9-1.8-0.7-2.81.9-0.9-0.7-0.10.30.3-0.2-0.10.31.11.6
Bone volume0.81.57.0-1.7-1.7-0.5-2.61.9-0.8-0.7-0.00.30.3-0.0-0.00.31.21.7
Breakpoint value in progressive ratio session3.54.25.1-1.9-1.9-2.1-1.31.7-2.1-2.2-2.2-2.3-2.2-2.2-2.2-2.2-2.1-2.0
Number of licking bursts0.20.31.40.80.80.51.2-0.70.40.2-0.1-0.2-0.20.10.1-0.2-0.5-0.7
Context. condit. distance diff. score0.30.40.50.40.70.40.7-0.60.70.70.70.60.60.60.60.70.40.4
Locomotion velocity, session 10.70.72.5-1.2-1.3-0.8-1.61.3-0.9-0.8-0.5-0.4-0.4-0.6-0.6-0.4-0.00.2
Locomotion distance, session 10.81.04.9-1.8-1.4-0.9-2.21.1-0.8-0.6-0.00.10.1-0.3-0.30.10.81.1
Locomotion velocity, session 24.55.211.2-3.3-3.0-2.7-3.32.8-2.5-2.3-1.8-1.5-1.5-2.1-2.1-1.7-0.9-0.5
Locomotion distance, session 22.23.19.9-2.5-2.6-1.8-3.12.2-2.0-1.8-1.2-1.0-1.0-1.4-1.4-1.1-0.20.2
Locomotion velocity, session 35.96.78.1-2.5-2.5-2.8-1.82.4-2.7-2.7-2.7-2.6-2.6-2.8-2.8-2.7-2.6-2.5
Locomotion distance, session 30.00.00.10.20.20.10.4-0.10.10.1-0.0-0.0-0.0-0.0-0.0-0.0-0.2-0.3
Stereotopy head waving bouts, day 35.16.08.1-2.8-2.9-2.7-2.52.5-2.7-2.6-2.3-2.2-2.2-2.5-2.5-2.5-1.9-1.6
Stereotopy head waving duration, day 36.17.39.1-2.9-3.0-3.0-2.52.8-2.9-2.9-2.6-2.5-2.5-2.8-2.8-2.9-2.3-2.1
Locomotion velocity, session 70.40.50.9-0.7-0.4-0.8-0.21.0-0.6-0.6-0.8-0.8-0.8-0.6-0.6-0.6-0.8-0.7
Locomotion distance, session 70.30.41.80.91.00.61.3-0.80.70.60.20.10.10.50.40.3-0.1-0.3
Stereotopy head waving bouts, day 70.20.20.9-0.5-0.5-0.1-1.00.5-0.2-0.10.30.40.40.10.10.10.60.7
Stereotopy head waving duration, day 70.50.62.4-1.1-1.2-0.7-1.61.1-0.8-0.7-0.3-0.2-0.2-0.5-0.5-0.40.10.4
Locomotion velocity, session 81.01.14.4-1.7-1.6-1.1-2.11.5-1.1-0.9-0.5-0.3-0.3-0.7-0.7-0.40.20.5
Locomotion distance, session 80.30.41.5-1.2-0.9-0.8-1.10.7-0.6-0.5-0.3-0.2-0.2-0.4-0.4-0.20.10.2
Degree of sensitization distance0.40.50.60.50.70.60.5-0.60.70.70.70.70.70.80.80.80.70.6
Degree of sensitization stereotypy1.61.82.61.00.91.40.3-0.91.21.31.51.61.61.41.41.41.61.6
Conditioned locomotion1.51.74.01.81.81.52.0-1.71.41.31.00.90.91.11.10.90.50.2
Cocaine response after cond. corrected5.56.611.53.33.32.63.4-3.02.92.72.32.12.12.52.52.11.41.0
Cocaine response after cond. not corrected5.96.912.23.33.42.63.5-3.23.02.82.42.22.22.52.52.21.41.0
Cocaine response before conditioning0.50.60.9-1.0-0.9-0.7-0.80.9-0.8-0.8-0.8-0.7-0.7-0.8-0.8-0.7-0.6-0.5
Saline control response0.20.20.70.80.60.50.7-0.70.50.40.30.20.20.30.30.20.1-0.0
Bone: connectivity density0.40.62.3-0.3-0.20.4-0.90.20.30.40.81.01.00.70.70.91.31.5
Bone: cortical apparent density0.81.21.51.21.01.20.7-0.91.11.11.11.11.11.11.11.11.11.0
Bone: cortical area0.40.71.80.30.30.8-0.20.00.60.60.81.01.00.90.91.01.21.3
Bone: cortical porosity0.20.20.8-0.6-0.7-0.3-0.90.8-0.5-0.5-0.3-0.2-0.2-0.3-0.3-0.20.10.2
Bone: cortical porosity0.20.31.3-0.6-0.7-0.1-1.10.7-0.3-0.20.10.20.20.10.10.30.60.8
Bone: cortical thickness1.01.62.70.90.91.40.3-0.81.21.21.41.51.51.41.41.51.61.6
Bone: cortical thickness0.20.20.90.60.60.21.0-0.30.1-0.0-0.3-0.4-0.4-0.1-0.1-0.4-0.7-0.8
Bone: cortical tissue density0.60.81.11.00.81.00.5-0.70.90.90.90.90.90.90.90.90.90.9
Condit. Reinf. active minus inactive responses4.34.86.6-2.3-2.3-2.6-1.72.1-2.3-2.2-2.1-2.1-2.1-2.3-2.3-2.2-2.1-1.9
Condit. Reinf. active-inactive response ratio2.12.23.3-1.1-1.1-1.6-0.51.2-1.4-1.4-1.6-1.6-1.6-1.6-1.6-1.6-1.8-1.8
Condit. Reinf. active responses3.94.97.5-2.7-2.6-2.6-2.52.5-2.4-2.3-2.0-1.9-1.9-2.2-2.2-2.0-1.5-1.2
Condit. Reinf. inactive responses1.11.44.6-1.8-1.7-1.2-2.11.6-1.3-1.1-0.7-0.6-0.6-0.9-0.9-0.5-0.00.2
Incentive salience index mean2.53.05.1-2.3-2.1-2.1-2.01.9-1.9-1.8-1.5-1.4-1.4-1.8-1.7-1.5-1.2-0.9
Condit. Reinf. lever presses0.50.63.4-1.2-1.1-0.5-1.80.8-0.5-0.40.10.30.3-0.1-0.10.30.91.1
Condit. Reinf. active minus inactive responses2.02.54.3-0.7-1.0-1.1-0.31.2-1.5-1.6-1.9-1.9-1.9-1.7-1.7-1.9-2.1-2.1
Condit. Reinf. active-inactive response ratio0.30.41.10.80.40.40.9-0.5-0.0-0.2-0.4-0.6-0.6-0.3-0.3-0.6-0.8-1.0
Condit. Reinf. active responses1.92.73.7-1.0-1.3-1.2-0.71.6-1.6-1.8-1.9-1.9-1.9-1.7-1.7-1.9-1.9-1.8
Condit. Reinf. inactive responses1.01.32.0-1.0-1.0-1.0-0.71.4-1.1-1.2-1.2-1.2-1.2-1.1-1.1-1.2-1.2-1.0
Condit. Reinf. lever presses1.72.33.5-1.0-1.1-1.3-0.41.2-1.4-1.5-1.7-1.8-1.8-1.6-1.6-1.8-1.9-1.8
Condit. Reinf. lever reinforcers received1.42.03.4-0.5-0.9-0.8-0.21.2-1.3-1.5-1.7-1.7-1.7-1.5-1.5-1.7-1.8-1.8
Conditioned reinforcement - actives0.81.42.8-0.7-0.6-1.10.00.7-1.0-1.1-1.5-1.6-1.6-1.2-1.2-1.1-1.6-1.7
Conditioned reinforcement - inactives0.10.10.40.30.40.20.6-0.40.30.2-0.0-0.1-0.10.10.10.1-0.2-0.3
Conditioned locomotion7.19.311.1-3.1-3.0-3.1-2.43.0-3.2-3.3-3.3-3.3-3.3-3.1-3.1-3.0-2.8-2.5
Patch foraging indifference point 0 sec0.20.30.50.40.40.60.0-0.30.40.50.50.60.60.60.60.60.70.7
Patch foraging indifference point AUC0.81.11.5-0.8-1.0-1.0-0.50.9-1.0-1.2-1.2-1.2-1.2-1.1-1.1-1.1-1.1-1.1
Delay disc. indifference point, 0s delay7.27.913.01.91.92.80.6-2.12.62.73.13.23.33.13.13.23.63.6
Delay disc. indifference point, 16s delay0.20.20.40.50.30.40.3-0.30.40.50.50.60.50.40.40.40.40.4
Delay disc. indifference point, 2s delay5.86.58.02.12.22.61.3-2.22.52.62.82.82.82.82.82.62.82.8
Delay disc. indifference point, 24s delay0.70.81.41.21.01.01.0-0.80.91.00.80.80.70.90.90.70.50.4
Delay disc. indifference point, 4s delay1.31.32.20.90.91.10.5-0.91.11.21.41.51.41.21.31.01.21.3
Delay disc. indifference point, 8s delay1.31.52.51.51.61.41.5-1.31.41.21.11.11.11.31.30.90.80.7
Indifference point function ln k0.10.30.60.70.80.50.7-0.50.60.60.40.40.40.50.50.40.20.2
Indifference point function log k0.10.30.60.70.80.50.7-0.50.60.60.40.40.40.50.50.40.20.2
Patch foraging total patch changes 0 sec0.10.20.40.40.30.50.1-0.30.40.40.50.50.50.50.50.50.60.6
Patch foraging total patch changes 12 sec0.40.51.10.90.90.71.0-1.10.80.70.60.50.50.70.60.50.40.3
Patch foraging total patch changes 18 sec0.81.21.5-1.1-1.2-1.2-1.01.1-1.2-1.2-1.1-1.0-1.0-1.1-1.1-1.1-0.9-0.8
Patch foraging total patch changes 24 sec0.10.10.3-0.3-0.5-0.3-0.50.3-0.4-0.4-0.3-0.2-0.2-0.3-0.3-0.3-0.1-0.0
Patch foraging total patch changes 6 sec0.20.30.6-0.4-0.7-0.4-0.80.7-0.6-0.7-0.5-0.4-0.4-0.5-0.5-0.4-0.2-0.1
Patch foraging time to switch 0 sec0.91.95.1-0.10.20.8-0.7-0.60.91.21.61.81.81.41.41.72.22.3
Patch foraging water rate 0 sec0.30.73.21.21.10.41.8-0.70.40.3-0.3-0.5-0.5-0.0-0.1-0.4-1.0-1.2
Patch foraging water rate 12 sec1.12.26.52.32.11.72.5-2.01.61.41.00.80.81.21.10.80.2-0.2
Patch foraging water rate 18 sec1.01.56.11.41.50.32.5-1.20.40.1-0.6-0.9-0.9-0.3-0.4-0.9-1.7-2.1
Patch foraging water rate 24 sec1.31.88.22.12.11.12.9-1.91.21.00.3-0.0-0.00.50.50.1-0.8-1.2
Patch foraging water rate 6 sec0.60.92.90.60.6-0.21.3-0.2-0.2-0.4-0.9-1.1-1.1-0.6-0.6-1.1-1.5-1.7
Seeking ratio, delayed vs. immediate footshock3.84.75.8-2.3-2.3-2.3-2.02.4-2.3-2.3-2.2-2.1-2.1-2.2-2.2-2.1-1.8-1.5
Distance traveled before self-admin0.10.20.40.20.30.4-0.0-0.10.40.40.40.40.40.50.50.60.60.7
Distance traveled after self-admin0.00.00.1-0.3-0.1-0.1-0.20.1-0.1-0.1-0.2-0.2-0.2-0.0-0.10.00.00.1
Extensor digitorum longus weight4.317.022.34.54.74.34.3-4.64.54.44.13.93.94.24.23.93.22.7
Bone: elastic displacement0.10.20.3-0.2-0.3-0.3-0.30.5-0.4-0.5-0.5-0.4-0.4-0.4-0.4-0.4-0.4-0.3
Bone: elastic work0.30.40.50.70.70.70.4-0.10.60.60.60.70.70.70.70.70.60.7
Bone: endosteal estimation0.20.30.50.40.50.50.2-0.30.60.60.70.70.70.60.60.70.60.6
Bone: endosteal perimeter0.30.61.3-1.1-1.0-0.9-1.01.2-0.8-0.8-0.6-0.5-0.5-0.7-0.7-0.6-0.4-0.2
Epididymis fat weight0.10.31.30.50.60.11.1-0.80.30.1-0.1-0.3-0.3-0.1-0.1-0.4-0.6-0.8
Delta time in closed arm before/after self-admin1.41.35.51.71.81.02.4-1.71.10.90.40.10.10.60.60.3-0.4-0.7
Delta time in open arm before/after self-admin0.60.50.80.70.70.70.5-0.60.80.80.90.90.90.80.80.70.70.7
Diff in mean of infusions in LGA sessions1.61.92.5-1.5-1.5-1.6-1.21.3-1.5-1.4-1.3-1.3-1.2-1.5-1.5-1.5-1.2-1.1
Delay discount exponential model param1.82.02.3-1.5-1.5-1.5-1.21.3-1.5-1.5-1.5-1.5-1.5-1.5-1.5-1.2-1.3-1.2
Extinction: sum of active levers before priming0.91.01.8-0.8-0.6-1.0-0.20.5-0.9-1.0-1.2-1.3-1.3-1.0-1.0-1.0-1.2-1.2
Active lever presses in extinction session 62.32.32.8-1.6-1.6-1.5-1.51.6-1.6-1.7-1.7-1.6-1.6-1.5-1.5-1.3-1.1-1.0
Bone: final force1.32.03.21.01.11.40.5-0.71.41.31.51.61.61.61.61.61.71.8
Bone: final moment1.01.62.60.91.01.30.4-0.61.21.21.41.51.51.41.51.51.51.6
Food consumed during 24 hour testing period0.60.81.21.11.10.91.0-0.91.00.90.80.80.80.90.90.80.60.5
Glucose2.74.36.12.52.22.51.9-2.12.22.22.12.02.02.12.12.01.71.6
Heart weight0.60.92.6-0.3-0.2-0.90.50.2-0.6-0.8-1.0-1.2-1.2-1.0-1.0-1.2-1.5-1.6
Delay discount hyperbolic model param3.13.44.0-1.9-1.8-2.0-1.41.6-1.9-1.9-1.9-2.0-2.0-2.0-2.0-1.7-1.8-1.7
Intermittent access intake day 1-15 change3.06.28.4-2.0-2.0-2.5-1.12.1-2.4-2.6-2.8-2.9-2.9-2.6-2.7-2.6-2.8-2.8
Intermittent access intake escalation2.75.57.3-1.8-1.9-2.3-1.01.9-2.3-2.4-2.7-2.7-2.7-2.5-2.5-2.5-2.7-2.6
Intermittent access intake escalation 24.24.86.1-1.8-1.9-2.2-1.12.0-2.2-2.3-2.4-2.5-2.5-2.3-2.3-2.3-2.4-2.4
Intermitt. access day 1 inactive lever presses0.10.51.40.50.5-0.11.1-0.50.0-0.2-0.6-0.8-0.8-0.3-0.4-0.6-1.0-1.2
Intermitt. access day 15 inactive lever presses0.20.50.6-0.8-0.8-0.8-0.60.7-0.7-0.7-0.7-0.6-0.6-0.7-0.7-0.7-0.5-0.5
Intermitt. access escalation Index0.71.02.10.50.40.9-0.2-0.40.70.81.11.21.21.01.01.31.41.5
Intermittent access day 1 total infusions0.10.20.7-0.10.1-0.30.5-0.2-0.2-0.2-0.5-0.6-0.6-0.4-0.4-0.5-0.8-0.8
Intermittent access day 15 total infusions2.33.55.0-1.5-1.4-1.9-0.71.4-1.8-1.9-2.2-2.2-2.2-2.0-2.0-1.9-2.1-2.1
Intermittent access terminal intake (last 3 days)1.82.33.5-1.3-1.2-1.5-0.61.2-1.4-1.5-1.8-1.9-1.9-1.6-1.6-1.5-1.7-1.6
Intermittent access total infusions0.91.11.8-0.9-0.7-1.1-0.20.7-0.9-1.0-1.3-1.4-1.4-1.1-1.1-1.0-1.3-1.3
Intermittent access day 1 locomotion1.41.83.6-0.8-0.7-1.30.00.6-1.1-1.2-1.5-1.7-1.7-1.4-1.4-1.5-1.8-1.9
Intermittent access day 15 total locomotion2.85.17.0-1.9-1.8-2.3-0.91.7-2.2-2.3-2.5-2.6-2.6-2.4-2.4-2.3-2.6-2.6
Intermittent access total locomotion2.32.74.0-1.3-1.2-1.7-0.51.1-1.5-1.7-1.9-2.0-2.0-1.7-1.8-1.6-1.9-1.9
Intermittent access standard deviation3.57.38.9-2.6-2.5-2.8-1.82.8-2.7-2.9-3.0-3.0-3.0-2.8-2.8-2.7-2.7-2.5
Left kidney weight0.10.31.40.60.80.21.2-0.50.40.3-0.1-0.2-0.20.10.1-0.1-0.5-0.7
Right kidney weight0.41.94.1-0.7-0.5-1.30.30.9-1.1-1.2-1.6-1.7-1.7-1.4-1.4-1.6-2.0-2.0
Cocaine induced anxiety1.31.94.5-1.9-1.9-1.4-2.11.9-1.5-1.4-1.1-0.9-0.9-1.2-1.2-0.9-0.4-0.2
Post-drug Anxiety1.71.84.8-1.9-1.9-1.5-2.21.8-1.5-1.3-0.9-0.7-0.7-1.1-1.1-0.9-0.3-0.0
Baseline Anxiety0.10.10.1-0.1-0.1-0.20.00.1-0.2-0.2-0.3-0.3-0.3-0.3-0.3-0.3-0.4-0.4
Tail length3.212.514.9-3.4-3.1-3.7-2.23.5-3.6-3.6-3.9-3.8-3.8-3.7-3.7-3.7-3.6-3.4
Length with tail1.87.99.2-2.8-2.5-3.0-1.82.8-2.8-2.9-3.0-3.0-3.0-2.9-2.9-2.9-2.8-2.7
Length without tail0.00.00.10.20.20.20.3-0.10.20.10.10.10.10.10.10.10.0-0.0
Times rat made contact with spout0.30.31.20.90.80.61.1-0.70.60.50.30.20.20.40.40.2-0.0-0.2
Lifetime Intake0.50.61.2-0.6-0.4-0.8-0.00.4-0.6-0.7-1.0-1.1-1.1-0.8-0.8-0.8-1.0-1.0
Liver weight, left1.01.62.21.51.31.41.2-1.51.31.31.31.21.21.21.21.21.00.8
Liver weight, right0.61.12.21.31.51.01.5-1.11.21.10.90.80.81.01.01.00.50.4
Locomotor activity3.25.07.6-2.8-2.6-2.2-2.72.8-2.4-2.5-2.2-2.1-2.1-2.1-2.1-1.9-1.3-0.9
Locomotor testing distance1.83.25.0-2.2-2.2-1.8-2.22.2-2.0-2.0-1.8-1.6-1.6-1.6-1.6-1.5-1.0-0.7
Locomotor testing rearing0.00.10.30.30.20.10.5-0.0-0.0-0.2-0.3-0.4-0.4-0.2-0.2-0.4-0.5-0.5
Locomotion in novel chamber0.91.11.8-0.6-0.8-0.9-0.40.8-1.0-1.2-1.3-1.3-1.3-1.1-1.1-1.1-1.2-1.2
Locomotion in novel chamber post-restriction1.01.72.3-1.1-1.0-1.3-0.51.1-1.2-1.3-1.5-1.5-1.5-1.4-1.4-1.5-1.5-1.4
Fecal boli incidents, locomotor time 11.21.72.61.21.31.31.1-1.31.41.31.31.21.31.41.41.61.31.1
Change in fecal boli incidents, locomotor task0.20.20.5-0.4-0.4-0.3-0.60.7-0.5-0.4-0.6-0.5-0.4-0.3-0.3-0.2-0.3-0.1
Time >=10cm from walls, locomotor time 10.50.51.70.20.20.8-0.40.10.40.50.60.70.60.80.81.21.21.3
Bouts of movement, locomotor time 10.30.30.5-0.5-0.3-0.6-0.10.5-0.5-0.5-0.7-0.7-0.7-0.6-0.6-0.5-0.7-0.7
Total resting periods, locomotor time 10.40.40.6-0.7-0.5-0.8-0.30.7-0.6-0.6-0.7-0.7-0.7-0.7-0.7-0.5-0.7-0.7
Rest time, locomotor task time 10.30.31.0-1.0-0.7-0.8-0.70.7-0.6-0.5-0.5-0.5-0.4-0.5-0.5-0.2-0.3-0.2
Distance moved, locomotor task time 10.60.92.20.60.41.0-0.3-0.30.70.80.91.11.01.01.01.11.31.5
Vertical activity count, locomotor time 10.20.41.61.30.91.01.0-0.60.70.50.30.30.30.60.60.30.10.1
Time >=10cm from walls, locomotor time 21.11.62.61.51.61.51.5-1.21.41.21.01.00.91.31.31.20.90.8
Bouts of movement, locomotor time 20.40.61.9-1.2-1.2-0.9-1.41.2-0.8-0.7-0.4-0.3-0.3-0.6-0.6-0.5-0.00.1
Total resting periods, locomotor time 20.30.62.0-1.2-1.2-0.8-1.41.1-0.8-0.7-0.3-0.2-0.3-0.5-0.5-0.50.10.2
Rest time, locomotor task time 20.70.81.6-1.3-1.2-1.1-1.21.2-1.0-0.9-0.8-0.6-0.7-0.8-0.8-0.7-0.4-0.3
Distance moved, locomotor task time 20.60.71.21.01.00.91.0-1.10.90.90.80.70.70.90.80.70.60.5
Vertical activity count, locomotor time 20.60.82.31.21.30.91.5-1.31.00.80.60.40.50.80.80.60.20.0
Light reinforcement 14.310.615.4-3.9-3.7-3.6-3.43.5-3.6-3.4-3.1-2.9-2.9-3.3-3.3-3.0-2.5-2.1
Light reinforcement 21.82.83.9-2.0-1.9-1.8-1.91.9-1.9-1.7-1.6-1.5-1.5-1.7-1.7-1.5-1.2-1.0
Bone: marrow area0.20.30.50.40.50.40.3-0.30.60.60.70.70.70.60.60.70.60.6
Bone: maximum diameter0.91.73.5-1.7-1.7-1.4-1.81.9-1.4-1.4-1.1-1.0-1.0-1.2-1.1-1.0-0.6-0.4
Bone: maximum force1.22.12.71.31.41.50.8-0.81.51.41.51.61.61.61.71.61.61.6
Bone: maximum moment1.01.82.31.21.21.40.7-0.81.41.31.41.51.51.51.51.51.41.5
Mean time between licks in bursts2.45.96.8-2.1-2.4-2.4-1.72.3-2.5-2.6-2.6-2.6-2.6-2.6-2.6-2.6-2.4-2.3
Mean num. licks in bursts0.00.10.2-0.1-0.1-0.0-0.20.10.10.20.30.30.30.20.20.30.40.4
Cd content in liver0.20.20.4-0.4-0.6-0.2-0.60.6-0.5-0.5-0.4-0.4-0.4-0.4-0.4-0.4-0.3-0.2
Co content in liver1.51.82.3-1.0-1.1-1.1-0.71.2-1.3-1.4-1.5-1.5-1.5-1.4-1.4-1.5-1.5-1.4
Cu content in liver0.30.41.5-1.1-0.9-0.5-1.21.0-0.6-0.6-0.3-0.2-0.2-0.3-0.3-0.20.20.3
Fe content in liver0.10.20.3-0.4-0.2-0.4-0.00.1-0.3-0.4-0.4-0.5-0.5-0.4-0.4-0.5-0.5-0.6
K content in liver0.20.20.9-0.6-0.6-0.2-1.00.5-0.3-0.3-0.00.10.1-0.1-0.10.10.40.6
Mg content in liver0.30.30.7-0.6-0.8-0.5-0.80.8-0.7-0.7-0.5-0.5-0.5-0.5-0.5-0.5-0.2-0.1
Mn content in liver1.92.15.6-2.1-2.0-1.5-2.42.2-1.6-1.4-1.1-0.8-0.8-1.1-1.1-0.8-0.30.1
Na content in liver0.90.92.50.10.30.7-0.4-0.50.70.81.11.21.21.01.01.21.51.6
Rb content in liver0.20.31.4-0.7-0.7-0.2-1.20.8-0.4-0.20.00.20.2-0.0-0.00.20.50.8
Se content in liver0.20.30.6-0.8-0.4-0.6-0.30.3-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5
Sr content in liver0.00.00.20.30.30.10.5-0.30.20.10.0-0.0-0.00.10.1-0.0-0.1-0.2
Zn content in liver3.74.17.9-1.0-1.2-1.8-0.11.2-1.8-1.9-2.3-2.4-2.4-2.2-2.2-2.4-2.7-2.8
Bone: minimum diameter0.00.10.2-0.2-0.1-0.0-0.40.40.00.00.20.30.30.20.20.30.40.5
Time in familiar zone, hab. session 12.22.12.9-1.3-1.1-1.6-0.51.2-1.3-1.4-1.5-1.5-1.5-1.5-1.5-1.7-1.7-1.7
Time in novel zone, hab. session 11.11.12.20.80.61.2-0.0-0.50.91.01.11.21.21.11.11.31.41.5
Total zone transitions, hab. session 11.21.65.3-1.8-1.9-1.3-2.31.6-1.4-1.3-0.8-0.7-0.7-1.0-1.0-0.9-0.10.2
Total locomotion distance, hab. session 11.72.38.0-2.4-2.2-1.6-2.82.2-1.6-1.4-0.9-0.7-0.7-1.1-1.1-0.90.00.4
Locomotion velocity, hab. session 12.13.08.4-2.6-2.4-1.9-2.92.2-1.9-1.7-1.2-1.0-1.0-1.4-1.4-1.2-0.30.1
Time in familiar zone, hab. session 26.26.58.8-2.2-2.1-2.7-1.02.0-2.5-2.5-2.7-2.8-2.8-2.8-2.8-2.8-3.0-2.9
Time in novel zone, hab. session 24.74.86.51.91.82.30.8-1.62.12.22.32.42.42.42.42.42.52.6
Total zone transitions, hab. session 20.81.03.8-0.9-0.90.1-1.90.5-0.10.10.70.90.90.50.50.81.61.9
Total locomotion distance, hab. session 21.52.06.1-2.2-2.1-1.6-2.51.7-1.6-1.4-0.9-0.7-0.7-1.2-1.1-1.0-0.10.1
Locomotion velocity, hab. session 21.72.27.9-2.3-2.2-1.6-2.81.8-1.6-1.4-0.8-0.6-0.6-1.1-1.1-0.90.10.4
Novel to familiar place preference ratio4.04.47.01.61.52.10.5-1.41.92.12.32.42.42.32.32.52.62.6
Novelty place preference2.52.74.81.11.11.60.2-1.01.41.61.81.91.91.81.82.02.12.2
Time in novel zone, NPP test2.83.04.91.31.31.70.4-1.21.61.71.92.02.01.91.92.12.22.2
Total zone transitions, NPP test0.30.52.6-0.8-0.9-0.2-1.60.5-0.4-0.20.30.40.40.00.00.21.01.1
Total locomotion distance, NPP test0.40.52.3-0.9-0.9-0.3-1.50.6-0.3-0.20.30.50.50.10.10.20.91.1
Locomotion velocity, NPP test0.40.63.1-1.1-1.1-0.5-1.70.8-0.6-0.50.00.20.2-0.2-0.2-0.10.70.9
Intraocular pressure0.30.52.31.00.80.21.5-0.90.30.1-0.2-0.4-0.4-0.1-0.1-0.3-0.8-1.1
Delta distance traveled before/after self-admin0.40.40.5-0.6-0.5-0.6-0.30.5-0.6-0.6-0.6-0.6-0.7-0.7-0.7-0.7-0.7-0.7
Delta ambulatory time before/after self-admin0.30.40.6-0.8-0.6-0.7-0.50.6-0.7-0.6-0.6-0.6-0.6-0.7-0.7-0.6-0.6-0.5
Parametrial fat weight0.00.00.2-0.2-0.3-0.1-0.50.1-0.1-0.10.00.00.00.00.00.20.30.3
Pavlov. Cond. lever latency0.30.41.81.10.80.51.3-0.50.30.3-0.2-0.3-0.3-0.0-0.0-0.1-0.7-0.9
Pavlov. Cond. magazine entry latency3.24.15.9-2.4-2.1-2.4-1.71.7-2.1-2.1-2.0-2.0-2.0-2.1-2.1-2.0-1.8-1.7
Pavlov. Cond. change in total contacts0.10.10.5-0.7-0.3-0.5-0.40.2-0.3-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.0-0.0
Pavlov. Cond. index score0.60.82.4-1.6-1.1-1.2-1.30.8-0.9-0.8-0.6-0.5-0.5-0.7-0.7-0.7-0.3-0.1
Pavlov. Cond. latency score0.70.92.9-1.7-1.3-1.3-1.51.0-0.9-0.8-0.5-0.4-0.4-0.7-0.7-0.6-0.10.1
Pavlov. Cond. lever contacts0.30.31.3-1.0-0.6-0.4-1.20.4-0.3-0.20.20.30.30.10.10.10.70.8
Pavlov. Cond. magazine entry number0.91.11.91.41.11.40.8-0.81.11.01.01.01.01.11.11.11.00.9
Pavlov. Cond. intertrial magazine entries0.20.20.80.20.1-0.10.6-0.0-0.2-0.3-0.5-0.6-0.6-0.4-0.4-0.6-0.8-0.9
Pavlov. Cond. lever-magazine prob. diff.0.70.92.6-1.6-1.2-1.3-1.30.9-1.0-0.9-0.7-0.6-0.6-0.9-0.9-0.8-0.4-0.3
Pavlov. Cond. response bias0.91.12.0-1.4-1.1-1.4-0.90.8-1.1-1.1-1.0-1.0-1.0-1.1-1.1-1.1-0.9-0.8
Pavlov. Cond. lever latency0.60.81.20.50.70.70.3-1.10.90.91.11.11.10.90.91.01.11.0
Pavlov. Cond. magazine entry latency0.40.40.7-0.6-0.5-0.8-0.30.8-0.6-0.6-0.7-0.7-0.7-0.7-0.7-0.6-0.7-0.6
Pavlov. Cond. change in total contacts0.40.71.1-0.2-0.5-0.5-0.10.8-0.7-0.8-1.0-1.0-1.0-0.8-0.8-1.0-1.1-1.0
Pavlov. Cond. index score0.50.71.1-0.4-0.6-0.7-0.20.9-0.8-0.8-1.0-1.0-1.0-0.9-0.8-0.9-1.0-1.0
Pavlov. Cond. latency score0.50.71.1-0.5-0.7-0.8-0.41.0-0.8-0.9-1.0-1.0-1.0-0.9-0.8-0.9-1.0-0.9
Pavlov. Cond. lever contacts0.50.61.2-0.3-0.4-0.5-0.00.8-0.7-0.7-1.0-1.0-1.0-0.8-0.8-0.9-1.1-1.0
Pavlov. Cond. magazine entry number0.60.71.10.80.81.00.5-1.00.90.80.90.90.90.90.90.90.90.8
Pavlov. Cond. intertrial magazine entries0.30.51.11.00.91.01.0-0.80.80.70.60.50.50.60.60.50.20.1
Pavlov. Cond. lever-magazine prob. diff.0.60.81.1-0.6-0.7-0.8-0.41.1-0.9-0.9-1.0-1.0-1.0-0.9-0.9-0.9-1.0-0.9
Pavlov. Cond. response bias1.31.83.0-0.7-0.9-1.1-0.31.3-1.3-1.3-1.6-1.6-1.6-1.4-1.4-1.5-1.7-1.6
Time in closed arm before self-admin0.40.51.60.0-0.00.5-0.6-0.20.40.50.80.90.90.70.70.91.21.3
Time in closed arm after self-admin0.20.20.5-0.0-0.1-0.30.3-0.0-0.3-0.3-0.5-0.5-0.5-0.4-0.5-0.5-0.7-0.7
Time in open arm before self-admin0.10.10.2-0.4-0.3-0.3-0.40.5-0.4-0.4-0.5-0.5-0.4-0.3-0.3-0.2-0.3-0.2
Time in open arm after self-admin1.01.11.21.01.01.10.8-0.91.11.11.11.11.11.11.11.01.00.9
Bone: periosteal estimation0.20.51.40.10.20.5-0.30.10.50.50.80.90.90.70.80.91.01.2
Bone: periosteal perimeter0.20.31.0-0.8-0.7-0.4-1.01.0-0.5-0.5-0.3-0.1-0.1-0.2-0.2-0.10.10.4
Bone: post-yield work0.60.91.31.01.10.91.0-0.91.11.01.01.01.01.01.00.90.70.7
Progressive ratio test 1 active lever presses0.20.31.00.20.4-0.20.9-0.40.0-0.1-0.4-0.5-0.5-0.3-0.3-0.4-0.8-1.0
Progressive ratio test 1 breakpoint0.20.30.90.20.4-0.10.9-0.40.1-0.0-0.4-0.5-0.5-0.3-0.3-0.4-0.8-0.9
Progressive ratio test 1 inactive lever presses0.20.40.8-0.5-0.3-0.70.10.3-0.4-0.5-0.7-0.7-0.7-0.6-0.6-0.5-0.8-0.9
Progressive ratio test 2 active lever presses0.40.51.60.20.4-0.30.9-0.3-0.1-0.3-0.8-0.9-0.9-0.5-0.5-0.5-1.1-1.3
Progressive ratio test 2 breakpoint0.50.51.80.10.3-0.30.9-0.2-0.2-0.4-0.8-1.0-1.0-0.6-0.6-0.6-1.2-1.3
Progressive ratio test 2 inactive lever presses0.10.20.4-0.5-0.3-0.4-0.10.2-0.3-0.4-0.6-0.6-0.6-0.4-0.4-0.2-0.4-0.4
Incentive Sensitization - Responses0.20.31.30.60.80.31.1-0.80.40.2-0.2-0.4-0.40.10.10.1-0.5-0.7
Incentive Sensitization - Breakpoint0.20.20.90.40.60.10.9-0.60.20.0-0.3-0.5-0.5-0.0-0.10.0-0.5-0.7
Sum of active levers in priming session hrs 5-60.00.00.0-0.00.10.10.1-0.20.10.10.10.00.10.10.10.20.10.2
Progressive ratio0.20.41.60.50.70.30.7-1.30.70.60.70.60.60.50.50.40.40.1
Food seeking constrained by brief footshock0.30.41.5-1.2-0.9-0.8-0.90.1-0.6-0.6-0.4-0.4-0.4-0.5-0.6-0.4-0.1-0.1
Seeking ratio, punishment vs. effort0.40.51.2-1.1-1.0-0.6-1.11.0-0.8-0.7-0.6-0.5-0.5-0.6-0.6-0.5-0.2-0.1
Retroperitoneal fat weight0.41.94.01.61.71.31.9-2.01.51.51.31.11.11.21.21.00.70.4
Reaction time number correct0.61.24.11.61.61.22.0-1.51.11.00.60.40.40.70.70.4-0.2-0.4
Reaction time mean minus median0.30.61.0-0.4-0.5-0.8-0.20.9-0.7-0.8-0.9-0.9-0.9-0.8-0.8-0.9-1.0-1.0
Reaction time mean minus median AUC0.00.10.4-0.3-0.3-0.1-0.60.6-0.10.00.20.30.30.10.20.30.40.5
Reaction time num false alarms0.30.51.91.11.20.61.4-0.60.70.60.20.20.20.40.50.2-0.2-0.3
Reaction time num false alarms AUC0.40.62.41.21.30.71.5-0.80.80.60.20.10.10.50.50.2-0.3-0.4
Reaction time trials correct on left0.61.24.11.61.61.22.0-1.51.11.00.60.40.40.70.70.4-0.2-0.4
Reaction time trials on left0.61.13.91.61.61.22.0-1.41.11.00.60.40.40.70.70.4-0.1-0.4
Reaction time mean0.10.10.20.2-0.00.2-0.20.40.10.10.20.30.30.30.30.30.40.5
Reaction time mean AUC0.10.10.30.30.00.3-0.20.40.20.20.30.40.40.30.30.40.40.5
Median of all reaction times0.30.40.90.50.30.6-0.10.00.50.60.70.80.80.70.70.80.90.9
Reaction time omissions0.20.31.0-0.5-0.9-0.4-1.00.8-0.6-0.5-0.3-0.3-0.3-0.4-0.4-0.10.00.2
Reaction time false alarm rate0.00.10.20.30.50.20.3-0.10.30.20.20.20.20.30.30.20.10.1
Reaction time premature initiation rate0.91.22.0-0.5-0.8-1.0-0.30.8-1.0-1.1-1.2-1.3-1.3-1.2-1.2-1.3-1.4-1.4
Reaction time premature initiations0.51.03.10.3-0.0-0.50.80.1-0.5-0.6-1.0-1.2-1.2-0.9-1.0-1.2-1.6-1.8
Std. dev. reaction times0.10.10.5-0.1-0.3-0.3-0.20.7-0.3-0.4-0.4-0.3-0.3-0.3-0.3-0.3-0.4-0.3
Reaction time trials completed0.61.13.91.61.61.22.0-1.41.11.00.60.40.40.70.70.4-0.1-0.4
Reaction time trials AUC0.61.24.71.71.71.22.2-1.51.11.00.50.40.40.70.70.4-0.2-0.5
Run reversals in cocaine runway, females0.60.61.1-1.1-1.0-1.0-1.10.7-0.9-0.8-0.7-0.6-0.6-0.7-0.7-0.6-0.4-0.3
Run reversals in cocaine runway, males1.91.93.0-1.7-1.7-1.5-1.51.5-1.5-1.5-1.3-1.2-1.2-1.4-1.4-1.3-1.0-0.8
Latency to leave start box in cocaine runway0.50.62.1-0.7-1.2-0.3-1.51.2-0.9-1.0-0.7-0.6-0.6-0.6-0.6-0.3-0.10.2
Latency to leave start box in cocaine runway, F0.30.41.8-0.2-0.70.5-1.30.6-0.2-0.30.00.20.20.30.30.60.91.2
Latency to leave start box in cocaine runway, M1.71.62.3-0.8-0.9-1.2-0.51.1-1.2-1.2-1.3-1.4-1.4-1.4-1.4-1.4-1.5-1.5
Std. dev. time between licks in bursts0.60.92.2-0.8-1.1-0.6-1.01.5-1.0-1.0-1.0-0.8-0.8-0.9-0.9-0.8-0.7-0.5
Total sessions with >9 infusions0.30.30.8-0.2-0.1-0.40.30.3-0.3-0.5-0.8-0.9-0.9-0.5-0.5-0.5-0.8-0.9
Short access day 1 total inactive lever presses0.30.40.7-0.6-0.5-0.7-0.20.5-0.6-0.7-0.8-0.8-0.8-0.7-0.7-0.6-0.7-0.8
Short access day 10 total inactive lever presses0.00.10.40.30.40.10.6-0.40.20.1-0.2-0.3-0.30.00.0-0.2-0.3-0.4
Short access day 1 total infusions0.30.40.6-0.7-0.6-0.8-0.30.7-0.6-0.6-0.7-0.7-0.7-0.7-0.7-0.5-0.7-0.7
Short access day 10 total infusions0.10.20.60.00.2-0.20.6-0.3-0.0-0.1-0.4-0.5-0.5-0.3-0.3-0.4-0.6-0.8
Short access total infusions0.30.40.8-0.4-0.3-0.60.10.3-0.4-0.6-0.8-0.9-0.9-0.6-0.6-0.6-0.8-0.8
Short access day 1 locomotion1.31.62.3-1.2-1.0-1.3-0.61.2-1.2-1.3-1.5-1.5-1.5-1.3-1.3-1.1-1.4-1.3
Short access day 10 total locomotion4.07.310.9-2.0-1.8-2.6-0.72.0-2.5-2.7-3.2-3.3-3.3-2.8-2.9-2.9-3.2-3.2
Short access total locomotion2.22.74.3-1.3-1.1-1.6-0.51.4-1.5-1.7-2.0-2.1-2.1-1.7-1.7-1.6-1.9-1.9
One hour access (0.3 mA shock)0.00.00.30.20.40.10.5-0.30.20.1-0.1-0.1-0.10.10.10.0-0.2-0.2
Compulsive drug intake1.01.23.30.50.41.0-0.4-0.20.80.91.21.31.31.21.21.41.71.8
One hour access (shock baseline)0.40.72.0-0.3-0.1-0.70.50.1-0.5-0.6-0.9-1.0-1.0-0.8-0.8-1.0-1.3-1.4
Social response proportion1.01.12.3-1.2-1.5-1.0-1.41.3-1.2-1.1-0.9-0.8-0.8-1.0-1.0-0.9-0.5-0.4
Social responses7.19.212.4-3.3-3.4-3.2-2.93.5-3.2-3.3-3.1-3.0-3.0-3.0-3.0-2.9-2.4-2.1
Social time0.40.50.80.60.50.80.4-0.90.70.70.80.70.70.70.70.70.80.7
Soleus weight8.224.227.64.95.05.34.0-4.75.25.25.15.05.05.25.25.04.54.1
Bone: stiffness2.54.15.11.61.82.01.1-1.52.12.12.22.32.32.22.22.22.22.1
Tibialis anterior weight1.13.74.21.82.02.01.6-2.02.12.02.02.02.02.02.01.91.71.6
Time to tail flick, vehicle, before self-admin0.10.10.3-0.6-0.5-0.4-0.60.4-0.3-0.3-0.2-0.2-0.1-0.2-0.2-0.20.00.1
Time to tail flick, vehicle, after self-admin0.40.52.0-0.10.1-0.50.8-0.1-0.3-0.3-0.6-0.7-0.7-0.7-0.7-0.9-1.2-1.4
Time to tail flick, test, before self-admin0.40.41.0-0.8-0.9-0.6-1.00.9-0.7-0.6-0.5-0.4-0.3-0.5-0.5-0.4-0.20.0
Time to tail flick, test, after self-admin0.10.10.1-0.2-0.3-0.4-0.30.3-0.3-0.3-0.2-0.2-0.2-0.3-0.3-0.3-0.3-0.3
Delta time to tail flick, vehicle, before/after SA0.50.52.30.81.10.51.5-1.10.70.60.30.10.10.30.30.0-0.4-0.7
Delta time to tail flick, test, before/after SA0.20.20.80.40.50.10.9-0.50.20.1-0.1-0.2-0.2-0.1-0.1-0.3-0.5-0.7
Tibia length0.82.22.9-1.3-1.3-1.5-0.91.4-1.5-1.6-1.6-1.6-1.6-1.5-1.5-1.7-1.5-1.4
Ambulatory time before self-admin0.10.20.40.30.30.50.1-0.20.40.40.40.40.40.50.50.60.60.6
Ambulatory time after self-admin0.00.00.1-0.3-0.10.0-0.20.1-0.0-0.0-0.0-0.0-0.00.10.10.20.20.2
Bone: tissue strength1.81.82.41.21.11.40.6-1.11.31.31.51.51.51.51.51.51.51.5
Total heroin consumption1.51.82.4-1.6-1.5-1.5-1.41.3-1.5-1.4-1.3-1.3-1.3-1.4-1.4-1.3-1.0-0.9
Bone: trabecular number0.50.92.7-1.5-1.3-1.0-1.61.3-1.0-0.9-0.6-0.4-0.4-0.7-0.6-0.5-0.00.2
Bone: trabecular spacing1.01.35.61.91.81.12.4-1.71.10.90.40.10.10.50.50.2-0.5-0.8
Bone: trabecular thickness1.01.35.3-1.2-1.3-0.0-2.31.4-0.4-0.20.40.70.70.40.40.81.62.0
Bone: trabecular tissue density1.21.82.91.41.51.41.3-1.71.51.41.41.31.31.41.41.31.11.0
Water consumed over 24 hours0.70.91.40.70.81.00.3-0.60.90.91.01.11.11.11.11.11.11.2
Number of responses in last shaping day1.61.82.8-0.8-0.9-1.3-0.20.9-1.1-1.3-1.6-1.7-1.7-1.4-1.4-1.4-1.6-1.7