Hub : Genes

Reep6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Reep6 0.21 0.14 3.5e-04 0.16 0.14 0.15 0.15 1.3e-04 3.8e-04 2.3e-04 2.1e-04
2 pVTA gene expression Reep6 0.06 0.05 7.1e-04 0.01 0.02 0.02 0.02 4.1e-02 1.7e-02 1.5e-02 1.1e-02
3 Brain gene expression Reep6 0.1 0.08 6.2e-08 0.06 0.07 0.06 0.07 2.0e-06 6.0e-07 1.1e-06 5.6e-07
4 pVTA intron excision ratio chr7_10027938_10031130 0.05 0.04 6.6e-03 0.02 0.03 0.02 0.02 1.2e-02 2.9e-03 7.3e-03 4.5e-03
5 pVTA intron excision ratio chr7_10033620_10037762 0.17 0.1 4.3e-10 0.13 0.13 0.13 0.13 2.0e-10 2.6e-10 2.4e-10 2.7e-10
6 NAcc gene expression Reep6 0.04 0.03 7.5e-07 0.03 0.04 0.03 0.04 5.7e-06 7.6e-07 1.1e-05 1.0e-06
7 NAcc mRNA stability Reep6 0.02 0.02 1.8e-04 0.01 0.01 0.02 0.01 5.2e-03 2.6e-03 1.5e-03 6.0e-03
8 Eye mRNA stability Reep6 0.31 0.18 1.1e-03 0.12 0.1 0.13 0.12 7.4e-03 1.1e-02 5.5e-03 7.2e-03
9 Liver mRNA stability Reep6 0.02 0.02 1.7e-03 0.02 0.02 0.01 0.02 2.2e-03 4.6e-03 1.9e-02 5.9e-03
10 PL gene expression Reep6 0.03 0.02 2.3e-04 0.03 0.03 0.03 0.02 2.9e-04 5.8e-04 6.8e-04 1.1e-03
11 IC gene expression Reep6 0.15 0.1 8.9e-06 0.08 0.09 0.09 0.09 3.4e-04 1.2e-04 1.7e-04 1.9e-04
12 BLA intron excision ratio chr7_10027753_10027845 0.05 0.04 1.4e-03 0.03 0.04 0.03 0.03 1.7e-02 2.9e-03 1.3e-02 7.9e-03
13 NAcc intron excision ratio chr7_10027753_10027845 0.01 0.01 3.3e-03 0.01 0.01 0.01 0.01 3.6e-03 1.2e-02 3.8e-02 1.4e-02
14 BLA gene expression Reep6 0.05 0.04 7.6e-03 0.02 0.03 0.02 0.01 2.2e-02 1.8e-02 2.4e-02 5.0e-02
15 Liver gene expression Reep6 0.44 0.17 0.0e+00 0.34 0.38 0.38 0.38 4.5e-39 4.5e-44 5.8e-44 8.0e-44

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.40.72.50.8-0.80.1-1.5-0.8-0.10.0-0.4-0.7-0.70.40.5-0.71.31.6
Area under the delay curve1.62.42.9-1.61.61.61.21.41.7-1.6-1.7-1.7-1.71.71.7-1.41.41.4
BMI with tail6.221.725.6-4.94.84.94.05.14.9-4.9-4.8-4.6-4.64.84.7-4.74.13.6
BMI without tail1.16.18.1-2.82.82.62.62.82.7-2.7-2.4-2.3-2.32.52.5-2.41.81.5
Body weight0.94.04.6-2.12.02.11.72.12.1-2.1-2.0-2.0-2.02.12.0-2.11.81.6
Weight adjusted by age0.20.61.6-1.21.10.91.30.80.8-0.7-0.4-0.3-0.30.60.6-0.60.10.0
Bone surface0.81.67.71.9-1.8-0.7-2.8-1.9-0.90.70.1-0.3-0.3-0.2-0.1-0.31.11.6
Bone volume0.71.57.01.7-1.7-0.5-2.6-1.9-0.80.70.0-0.3-0.3-0.0-0.0-0.31.21.7
Breakpoint value in progressive ratio session2.34.25.11.9-1.9-2.1-1.3-1.7-2.12.22.22.32.2-2.2-2.22.2-2.1-2.0
Number of licking bursts0.10.31.4-0.80.80.51.20.70.4-0.20.10.20.20.10.10.2-0.5-0.7
Context. condit. distance diff. score0.30.40.5-0.40.70.40.70.60.7-0.7-0.7-0.6-0.60.60.6-0.70.40.4
Locomotion velocity, session 10.70.72.51.2-1.3-0.8-1.6-1.3-0.90.80.50.40.4-0.6-0.60.4-0.00.2
Locomotion distance, session 10.81.04.91.8-1.4-0.9-2.2-1.1-0.80.60.0-0.1-0.1-0.3-0.3-0.10.81.1
Locomotion velocity, session 24.35.211.23.3-3.0-2.7-3.3-2.8-2.52.31.81.51.5-2.1-2.11.7-0.9-0.5
Locomotion distance, session 22.23.19.92.5-2.6-1.8-3.1-2.2-2.01.81.21.01.0-1.4-1.41.1-0.20.2
Locomotion velocity, session 35.96.78.12.5-2.5-2.8-1.8-2.4-2.72.72.72.62.6-2.8-2.82.7-2.6-2.5
Locomotion distance, session 30.00.00.1-0.20.20.10.40.10.1-0.10.00.00.0-0.0-0.00.0-0.2-0.3
Stereotopy head waving bouts, day 35.16.08.22.8-2.9-2.7-2.5-2.5-2.72.62.32.22.2-2.5-2.52.5-1.9-1.6
Stereotopy head waving duration, day 35.97.39.12.9-3.0-3.0-2.5-2.8-2.92.92.62.52.5-2.8-2.82.9-2.3-2.1
Locomotion velocity, session 70.40.50.90.7-0.4-0.8-0.2-1.0-0.60.60.80.80.8-0.6-0.60.6-0.8-0.7
Locomotion distance, session 70.30.41.8-0.91.00.61.30.80.7-0.6-0.2-0.1-0.10.50.4-0.3-0.1-0.3
Stereotopy head waving bouts, day 70.20.20.90.5-0.5-0.1-1.0-0.5-0.20.1-0.3-0.4-0.40.10.1-0.10.60.7
Stereotopy head waving duration, day 70.50.62.41.1-1.2-0.7-1.6-1.1-0.80.70.30.20.2-0.5-0.50.40.10.4
Locomotion velocity, session 81.01.14.41.7-1.6-1.1-2.1-1.5-1.10.90.50.30.3-0.7-0.70.40.20.5
Locomotion distance, session 80.30.41.51.2-0.9-0.8-1.1-0.7-0.60.50.30.20.2-0.4-0.40.20.10.2
Degree of sensitization distance0.40.50.6-0.50.70.60.50.60.7-0.7-0.7-0.7-0.70.80.8-0.80.70.6
Degree of sensitization stereotypy1.61.82.6-1.01.01.40.30.91.2-1.3-1.5-1.6-1.61.41.4-1.41.61.6
Conditioned locomotion1.41.74.0-1.81.81.52.01.71.4-1.3-1.0-0.9-0.91.11.1-0.90.50.2
Cocaine response after cond. corrected4.46.611.5-3.33.32.63.43.02.9-2.7-2.3-2.1-2.12.52.5-2.11.41.0
Cocaine response after cond. not corrected4.86.912.2-3.33.42.63.53.23.0-2.8-2.4-2.2-2.22.52.5-2.21.41.0
Cocaine response before conditioning0.50.60.91.0-0.9-0.7-0.8-0.9-0.80.80.80.70.7-0.8-0.80.7-0.6-0.5
Saline control response0.20.20.7-0.80.60.50.70.70.5-0.4-0.3-0.2-0.20.30.3-0.20.1-0.0
Bone: connectivity density0.40.62.30.3-0.20.4-0.9-0.20.3-0.4-0.8-1.0-1.00.70.7-0.91.31.5
Bone: cortical apparent density0.71.21.5-1.21.01.20.70.91.1-1.1-1.1-1.1-1.11.11.1-1.11.11.0
Bone: cortical area0.40.71.8-0.30.30.8-0.2-0.00.6-0.6-0.8-1.0-1.00.90.9-1.01.21.3
Bone: cortical porosity0.20.20.80.6-0.7-0.3-0.9-0.8-0.50.50.30.20.2-0.3-0.30.20.10.2
Bone: cortical porosity0.20.31.30.6-0.7-0.1-1.1-0.7-0.30.2-0.1-0.2-0.20.10.1-0.30.60.8
Bone: cortical thickness1.01.62.7-0.90.91.40.30.81.2-1.2-1.4-1.5-1.51.41.4-1.51.61.6
Bone: cortical thickness0.20.20.9-0.60.60.21.00.30.10.00.30.40.4-0.1-0.10.4-0.7-0.8
Bone: cortical tissue density0.50.81.1-1.00.81.00.50.70.9-0.9-0.9-0.9-0.90.90.9-0.90.90.9
Condit. Reinf. active minus inactive responses4.34.86.62.3-2.3-2.6-1.7-2.1-2.32.22.12.12.1-2.3-2.32.2-2.1-1.9
Condit. Reinf. active-inactive response ratio2.12.23.31.1-1.1-1.6-0.5-1.2-1.41.41.61.61.6-1.6-1.61.6-1.8-1.8
Condit. Reinf. active responses3.84.97.52.7-2.6-2.6-2.5-2.5-2.42.32.01.91.9-2.2-2.22.0-1.5-1.2
Condit. Reinf. inactive responses1.11.44.61.8-1.7-1.2-2.1-1.6-1.31.10.70.60.6-0.9-0.90.5-0.00.2
Incentive salience index mean2.43.05.12.3-2.1-2.1-2.0-1.9-1.91.81.51.41.4-1.8-1.71.5-1.2-0.9
Condit. Reinf. lever presses0.40.63.41.2-1.1-0.5-1.8-0.8-0.50.4-0.1-0.3-0.3-0.1-0.1-0.30.91.1
Condit. Reinf. active minus inactive responses1.72.54.30.7-1.0-1.1-0.3-1.2-1.51.61.91.91.9-1.7-1.71.9-2.1-2.1
Condit. Reinf. active-inactive response ratio0.20.41.1-0.80.40.40.90.5-0.00.20.40.60.6-0.3-0.30.6-0.8-1.0
Condit. Reinf. active responses1.92.73.71.0-1.3-1.2-0.7-1.6-1.61.81.91.91.9-1.7-1.71.9-1.9-1.8
Condit. Reinf. inactive responses0.91.32.01.0-1.0-1.0-0.7-1.4-1.11.21.21.21.2-1.1-1.11.2-1.2-1.0
Condit. Reinf. lever presses1.62.33.51.0-1.1-1.3-0.4-1.2-1.41.51.71.81.8-1.6-1.61.8-1.9-1.8
Condit. Reinf. lever reinforcers received1.42.03.40.5-0.9-0.8-0.2-1.2-1.31.51.71.71.7-1.5-1.51.7-1.8-1.8
Conditioned reinforcement - actives0.41.42.80.7-0.6-1.10.0-0.7-1.01.11.51.61.6-1.2-1.21.1-1.6-1.7
Conditioned reinforcement - inactives0.00.10.4-0.30.40.20.60.40.3-0.20.00.10.10.10.1-0.1-0.2-0.3
Conditioned locomotion6.39.311.13.1-3.0-3.1-2.4-3.0-3.23.33.33.33.3-3.1-3.13.0-2.8-2.5
Patch foraging indifference point 0 sec0.10.30.5-0.40.40.60.00.30.4-0.5-0.5-0.6-0.60.60.6-0.60.70.7
Patch foraging indifference point AUC0.51.11.50.8-1.0-1.0-0.5-0.9-1.01.21.21.21.2-1.1-1.11.1-1.1-1.1
Delay disc. indifference point, 0s delay7.07.913.0-1.91.92.80.62.12.6-2.7-3.1-3.2-3.33.13.1-3.23.63.6
Delay disc. indifference point, 16s delay0.10.20.4-0.50.30.40.30.30.4-0.5-0.5-0.6-0.50.40.4-0.40.40.4
Delay disc. indifference point, 2s delay5.86.58.0-2.12.22.61.32.22.5-2.6-2.8-2.8-2.82.82.8-2.62.82.8
Delay disc. indifference point, 24s delay0.50.81.4-1.21.01.01.00.80.9-1.0-0.8-0.8-0.70.90.9-0.70.50.4
Delay disc. indifference point, 4s delay1.31.32.2-0.90.91.10.50.91.1-1.2-1.4-1.5-1.41.21.3-1.01.21.3
Delay disc. indifference point, 8s delay0.91.52.5-1.51.61.41.51.31.4-1.2-1.1-1.1-1.11.31.3-0.90.80.7
Indifference point function ln k0.10.30.6-0.70.80.50.70.50.6-0.6-0.4-0.4-0.40.50.5-0.40.20.2
Indifference point function log k0.10.30.6-0.70.80.50.70.50.6-0.6-0.4-0.4-0.40.50.5-0.40.20.2
Patch foraging total patch changes 0 sec0.10.20.4-0.40.30.50.10.30.4-0.4-0.5-0.5-0.50.50.5-0.50.60.6
Patch foraging total patch changes 12 sec0.40.51.1-0.90.90.71.01.10.8-0.7-0.6-0.5-0.50.70.6-0.50.40.3
Patch foraging total patch changes 18 sec0.51.21.51.1-1.2-1.2-1.0-1.1-1.21.21.11.01.0-1.1-1.11.1-0.9-0.8
Patch foraging total patch changes 24 sec0.00.10.30.3-0.5-0.3-0.5-0.3-0.40.40.30.20.2-0.3-0.30.3-0.1-0.0
Patch foraging total patch changes 6 sec0.20.30.60.4-0.7-0.4-0.8-0.7-0.60.70.50.40.4-0.5-0.50.4-0.2-0.1
Patch foraging time to switch 0 sec0.51.95.10.10.30.8-0.70.60.9-1.2-1.6-1.8-1.81.41.4-1.72.22.3
Patch foraging water rate 0 sec0.20.73.2-1.21.10.41.80.70.4-0.30.30.50.5-0.0-0.10.4-1.0-1.2
Patch foraging water rate 12 sec0.52.26.5-2.32.11.72.52.01.6-1.4-1.0-0.8-0.81.21.1-0.80.2-0.2
Patch foraging water rate 18 sec0.71.56.1-1.41.50.32.51.20.4-0.10.60.90.9-0.3-0.40.9-1.7-2.1
Patch foraging water rate 24 sec1.31.88.2-2.12.11.12.91.91.2-1.0-0.30.00.00.50.5-0.1-0.8-1.2
Patch foraging water rate 6 sec0.60.92.9-0.60.6-0.21.30.2-0.20.40.91.11.1-0.6-0.61.1-1.5-1.7
Seeking ratio, delayed vs. immediate footshock3.34.75.82.3-2.3-2.3-2.0-2.4-2.32.32.22.12.1-2.2-2.22.1-1.8-1.5
Distance traveled before self-admin0.10.20.4-0.20.30.4-0.00.10.4-0.4-0.4-0.4-0.40.50.5-0.60.60.7
Distance traveled after self-admin0.00.00.10.3-0.1-0.1-0.2-0.1-0.10.10.20.20.2-0.0-0.1-0.00.00.1
Extensor digitorum longus weight4.317.022.3-4.54.74.34.34.64.5-4.4-4.1-3.9-3.94.24.2-3.93.22.7
Bone: elastic displacement0.10.20.30.2-0.3-0.3-0.3-0.5-0.40.50.50.40.4-0.4-0.40.4-0.4-0.3
Bone: elastic work0.30.40.5-0.70.70.70.40.10.6-0.6-0.6-0.7-0.70.70.7-0.70.60.7
Bone: endosteal estimation0.10.30.5-0.40.50.50.20.30.6-0.6-0.7-0.7-0.70.60.6-0.70.60.6
Bone: endosteal perimeter0.20.61.31.1-1.0-0.9-1.0-1.2-0.80.80.60.50.5-0.7-0.70.6-0.4-0.2
Epididymis fat weight0.10.31.3-0.50.60.11.10.80.3-0.10.10.30.3-0.1-0.10.4-0.6-0.8
Delta time in closed arm before/after self-admin1.41.35.5-1.71.81.02.41.71.1-0.9-0.4-0.1-0.10.60.6-0.3-0.4-0.7
Delta time in open arm before/after self-admin0.50.50.8-0.70.70.70.50.60.8-0.8-0.9-0.9-0.90.80.8-0.70.70.7
Diff in mean of infusions in LGA sessions1.11.92.51.5-1.5-1.6-1.2-1.3-1.51.41.31.31.2-1.5-1.51.5-1.2-1.1
Delay discount exponential model param1.52.02.31.5-1.5-1.5-1.2-1.3-1.51.51.51.51.5-1.5-1.51.2-1.3-1.2
Extinction: sum of active levers before priming0.71.01.80.8-0.6-1.0-0.2-0.5-0.91.01.21.31.3-1.0-1.01.0-1.2-1.2
Active lever presses in extinction session 62.32.32.81.6-1.6-1.5-1.5-1.6-1.61.71.71.61.6-1.5-1.51.3-1.1-1.0
Bone: final force1.22.03.2-1.01.11.40.50.71.4-1.3-1.5-1.6-1.61.61.6-1.61.71.8
Bone: final moment1.01.62.6-0.91.01.30.40.61.2-1.2-1.4-1.5-1.51.41.5-1.51.51.6
Food consumed during 24 hour testing period0.40.81.2-1.11.10.91.00.91.0-0.9-0.8-0.8-0.80.90.9-0.80.60.5
Glucose2.74.36.1-2.52.22.51.92.12.2-2.2-2.1-2.0-2.02.12.1-2.01.71.6
Heart weight0.60.92.60.3-0.2-0.90.5-0.2-0.60.81.01.21.2-1.0-1.01.2-1.5-1.6
Delay discount hyperbolic model param2.63.44.01.9-1.8-2.0-1.4-1.6-1.91.91.92.02.0-2.0-2.01.7-1.8-1.7
Intermittent access intake day 1-15 change1.16.28.42.0-2.0-2.5-1.1-2.1-2.42.62.82.92.9-2.6-2.72.6-2.8-2.8
Intermittent access intake escalation1.05.57.31.8-1.9-2.3-1.0-1.9-2.32.42.72.72.7-2.5-2.52.5-2.7-2.6
Intermittent access intake escalation 22.94.86.11.8-1.9-2.2-1.1-2.0-2.22.32.42.52.5-2.3-2.32.3-2.4-2.4
Intermitt. access day 1 inactive lever presses0.00.51.4-0.50.5-0.11.10.50.00.20.60.80.8-0.3-0.40.6-1.0-1.2
Intermitt. access day 15 inactive lever presses0.10.50.60.8-0.8-0.8-0.6-0.7-0.70.70.70.60.6-0.7-0.70.7-0.5-0.5
Intermitt. access escalation Index0.31.02.1-0.50.40.9-0.20.40.7-0.8-1.1-1.2-1.21.01.0-1.31.41.5
Intermittent access day 1 total infusions0.10.20.70.10.1-0.30.50.2-0.20.20.50.60.6-0.4-0.40.5-0.8-0.8
Intermittent access day 15 total infusions1.43.55.01.5-1.4-1.9-0.7-1.4-1.81.92.22.22.2-2.0-2.01.9-2.1-2.1
Intermittent access terminal intake (last 3 days)1.32.33.51.3-1.2-1.5-0.6-1.2-1.41.51.81.91.9-1.6-1.61.5-1.7-1.6
Intermittent access total infusions0.91.11.80.9-0.7-1.1-0.2-0.7-0.91.01.31.41.4-1.1-1.11.0-1.3-1.3
Intermittent access day 1 locomotion1.01.83.60.8-0.7-1.30.0-0.6-1.11.21.51.71.7-1.4-1.41.5-1.8-1.9
Intermittent access day 15 total locomotion1.35.17.01.9-1.8-2.3-0.9-1.7-2.22.32.52.62.6-2.4-2.42.3-2.6-2.6
Intermittent access total locomotion2.32.74.01.3-1.2-1.7-0.5-1.1-1.51.71.92.02.0-1.7-1.81.6-1.9-1.9
Intermittent access standard deviation1.47.38.92.6-2.5-2.8-1.8-2.8-2.72.93.03.03.0-2.8-2.82.7-2.7-2.5
Left kidney weight0.00.31.4-0.60.80.21.20.50.4-0.30.10.20.20.10.10.1-0.5-0.7
Right kidney weight0.31.94.10.7-0.5-1.30.3-0.9-1.11.21.61.71.7-1.4-1.41.6-2.0-2.0
Cocaine induced anxiety0.71.94.51.9-1.9-1.4-2.1-1.9-1.51.41.10.90.9-1.2-1.20.9-0.4-0.2
Post-drug Anxiety1.61.84.81.9-1.9-1.5-2.2-1.8-1.51.30.90.70.7-1.1-1.10.9-0.3-0.0
Baseline Anxiety0.00.10.10.1-0.1-0.20.0-0.1-0.20.20.30.30.3-0.3-0.30.3-0.4-0.4
Tail length2.312.514.93.4-3.1-3.7-2.2-3.5-3.63.63.93.83.8-3.7-3.73.7-3.6-3.4
Length with tail1.87.99.22.8-2.5-3.0-1.8-2.8-2.82.93.03.03.0-2.9-2.92.9-2.8-2.7
Length without tail0.00.00.1-0.20.20.20.30.10.2-0.1-0.1-0.1-0.10.10.1-0.10.0-0.0
Times rat made contact with spout0.30.31.2-0.90.80.61.10.70.6-0.5-0.3-0.2-0.20.40.4-0.2-0.0-0.2
Lifetime Intake0.50.61.20.6-0.4-0.8-0.0-0.4-0.60.71.01.11.1-0.8-0.80.8-1.0-1.0
Liver weight, left0.91.62.2-1.51.31.41.21.51.3-1.3-1.3-1.2-1.21.21.2-1.21.00.8
Liver weight, right0.61.12.2-1.31.51.01.51.11.2-1.1-0.9-0.8-0.81.01.0-1.00.50.4
Locomotor activity3.25.07.62.8-2.6-2.2-2.7-2.8-2.42.52.22.12.1-2.1-2.11.9-1.3-0.9
Locomotor testing distance1.33.25.02.2-2.2-1.8-2.2-2.2-2.02.01.81.61.6-1.6-1.61.5-1.0-0.7
Locomotor testing rearing0.00.10.3-0.30.20.10.50.0-0.00.20.30.40.4-0.2-0.20.4-0.5-0.5
Locomotion in novel chamber0.81.11.80.6-0.8-0.9-0.4-0.8-1.01.21.31.31.3-1.1-1.11.1-1.2-1.2
Locomotion in novel chamber post-restriction0.61.72.31.1-1.0-1.3-0.5-1.1-1.21.31.51.51.5-1.4-1.41.5-1.5-1.4
Fecal boli incidents, locomotor time 10.71.72.6-1.21.31.31.11.31.4-1.3-1.3-1.2-1.31.41.4-1.61.31.1
Change in fecal boli incidents, locomotor task0.20.20.50.4-0.4-0.3-0.6-0.7-0.50.40.60.50.4-0.3-0.30.2-0.3-0.1
Time >=10cm from walls, locomotor time 10.40.51.7-0.20.20.8-0.4-0.10.4-0.5-0.6-0.7-0.60.80.8-1.21.21.3
Bouts of movement, locomotor time 10.30.30.50.5-0.3-0.6-0.1-0.5-0.50.50.70.70.7-0.6-0.60.5-0.7-0.7
Total resting periods, locomotor time 10.40.40.60.7-0.5-0.8-0.3-0.7-0.60.60.70.70.7-0.7-0.70.5-0.7-0.7
Rest time, locomotor task time 10.20.31.01.0-0.7-0.8-0.7-0.7-0.60.50.50.50.4-0.5-0.50.2-0.3-0.2
Distance moved, locomotor task time 10.30.92.2-0.60.41.0-0.30.30.7-0.8-0.9-1.1-1.01.01.0-1.11.31.5
Vertical activity count, locomotor time 10.10.41.6-1.30.91.01.00.60.7-0.5-0.3-0.3-0.30.60.6-0.30.10.1
Time >=10cm from walls, locomotor time 20.51.62.6-1.51.61.51.51.21.4-1.2-1.0-1.0-0.91.31.3-1.20.90.8
Bouts of movement, locomotor time 20.20.61.91.2-1.2-0.9-1.4-1.2-0.80.70.40.30.3-0.6-0.60.5-0.00.1
Total resting periods, locomotor time 20.10.62.01.2-1.1-0.8-1.4-1.1-0.80.70.30.20.3-0.5-0.50.50.10.2
Rest time, locomotor task time 20.50.81.61.3-1.2-1.1-1.2-1.2-1.00.90.80.60.7-0.8-0.80.7-0.4-0.3
Distance moved, locomotor task time 20.50.71.2-1.01.00.91.01.10.9-0.9-0.8-0.7-0.70.90.8-0.70.60.5
Vertical activity count, locomotor time 20.30.82.3-1.21.30.91.51.31.0-0.8-0.6-0.4-0.50.80.8-0.60.20.0
Light reinforcement 12.310.615.43.9-3.7-3.6-3.4-3.5-3.63.43.12.92.9-3.3-3.33.0-2.5-2.1
Light reinforcement 21.22.83.92.0-1.9-1.8-1.9-1.9-1.91.71.61.51.5-1.7-1.71.5-1.2-1.0
Bone: marrow area0.10.30.5-0.40.50.40.30.30.6-0.6-0.7-0.7-0.70.60.6-0.70.60.6
Bone: maximum diameter0.81.73.51.7-1.7-1.4-1.8-1.9-1.41.41.11.01.0-1.2-1.11.0-0.6-0.4
Bone: maximum force1.12.12.7-1.31.41.50.80.81.5-1.4-1.5-1.6-1.61.61.7-1.61.61.6
Bone: maximum moment1.01.82.3-1.21.21.40.70.81.4-1.3-1.4-1.5-1.51.51.5-1.51.41.5
Mean time between licks in bursts1.05.96.82.1-2.4-2.4-1.7-2.3-2.52.62.62.62.6-2.6-2.62.6-2.4-2.3
Mean num. licks in bursts0.00.10.20.1-0.1-0.0-0.2-0.10.1-0.2-0.3-0.3-0.30.20.2-0.30.40.4
Cd content in liver0.20.20.40.4-0.6-0.2-0.6-0.6-0.50.50.40.40.4-0.4-0.40.4-0.3-0.2
Co content in liver1.51.82.31.0-1.1-1.1-0.7-1.2-1.31.41.51.51.5-1.4-1.41.5-1.5-1.4
Cu content in liver0.30.41.51.1-0.9-0.5-1.2-1.0-0.60.60.30.20.2-0.3-0.30.20.20.3
Fe content in liver0.10.20.30.4-0.2-0.4-0.0-0.1-0.30.40.40.50.5-0.4-0.40.5-0.5-0.6
K content in liver0.20.20.90.6-0.6-0.2-1.0-0.5-0.30.30.0-0.1-0.1-0.1-0.1-0.10.40.6
Mg content in liver0.30.30.70.6-0.8-0.5-0.8-0.8-0.70.70.50.50.5-0.5-0.50.5-0.2-0.1
Mn content in liver1.82.15.62.1-2.0-1.5-2.4-2.2-1.61.41.10.80.8-1.1-1.10.8-0.30.1
Na content in liver0.80.92.5-0.10.30.7-0.40.50.7-0.8-1.1-1.2-1.21.01.0-1.21.51.6
Rb content in liver0.20.31.40.7-0.7-0.2-1.2-0.8-0.40.2-0.0-0.2-0.2-0.0-0.0-0.20.50.8
Se content in liver0.20.30.60.8-0.4-0.6-0.3-0.3-0.50.50.50.50.5-0.5-0.50.5-0.5-0.5
Sr content in liver0.00.00.2-0.30.30.10.50.30.2-0.1-0.00.00.00.10.10.0-0.1-0.2
Zn content in liver3.54.17.91.0-1.2-1.8-0.1-1.2-1.81.92.32.42.4-2.2-2.22.4-2.7-2.8
Bone: minimum diameter0.00.10.20.2-0.1-0.0-0.4-0.40.0-0.0-0.2-0.3-0.30.20.2-0.30.40.5
Time in familiar zone, hab. session 11.92.12.91.3-1.1-1.6-0.5-1.2-1.31.41.51.51.5-1.5-1.51.7-1.7-1.7
Time in novel zone, hab. session 11.01.12.2-0.80.61.2-0.00.50.9-1.0-1.1-1.2-1.21.11.1-1.31.41.5
Total zone transitions, hab. session 11.21.65.31.8-1.9-1.3-2.3-1.6-1.41.30.80.70.7-1.0-1.00.9-0.10.2
Total locomotion distance, hab. session 11.62.38.02.4-2.1-1.6-2.8-2.2-1.61.40.90.70.7-1.1-1.10.90.00.4
Locomotion velocity, hab. session 12.13.08.42.6-2.4-1.9-2.9-2.2-1.91.71.21.01.0-1.4-1.41.2-0.30.1
Time in familiar zone, hab. session 25.76.58.82.2-2.1-2.7-1.0-2.0-2.52.52.72.82.8-2.8-2.82.8-3.0-2.9
Time in novel zone, hab. session 24.44.86.5-1.91.82.30.81.62.1-2.2-2.3-2.4-2.42.42.4-2.42.52.6
Total zone transitions, hab. session 20.81.03.80.9-0.90.1-1.9-0.5-0.1-0.1-0.7-0.9-0.90.50.5-0.81.61.9
Total locomotion distance, hab. session 21.52.06.12.2-2.0-1.6-2.5-1.7-1.61.40.90.70.7-1.2-1.11.0-0.10.1
Locomotion velocity, hab. session 21.72.27.92.3-2.2-1.6-2.8-1.8-1.61.40.80.60.6-1.1-1.10.90.10.4
Novel to familiar place preference ratio3.44.47.0-1.61.52.10.51.41.9-2.1-2.3-2.4-2.42.32.3-2.52.62.6
Novelty place preference2.12.74.8-1.11.11.60.21.01.4-1.6-1.8-1.9-1.91.81.8-2.02.12.2
Time in novel zone, NPP test2.53.04.9-1.31.31.70.41.21.6-1.7-1.9-2.0-2.01.91.9-2.12.22.2
Total zone transitions, NPP test0.30.52.60.8-0.9-0.2-1.6-0.5-0.40.2-0.3-0.4-0.40.00.0-0.21.01.1
Total locomotion distance, NPP test0.30.52.30.9-0.9-0.3-1.5-0.6-0.30.2-0.3-0.5-0.50.10.1-0.20.91.1
Locomotion velocity, NPP test0.40.63.11.1-1.1-0.5-1.7-0.8-0.60.5-0.0-0.2-0.2-0.2-0.20.10.70.9
Intraocular pressure0.30.52.3-1.00.70.21.50.90.3-0.10.20.40.4-0.1-0.10.3-0.8-1.1
Delta distance traveled before/after self-admin0.40.40.50.6-0.5-0.6-0.3-0.5-0.60.60.60.60.7-0.7-0.70.7-0.7-0.7
Delta ambulatory time before/after self-admin0.20.40.60.8-0.6-0.7-0.5-0.6-0.70.60.60.60.6-0.7-0.70.6-0.6-0.5
Parametrial fat weight0.00.00.20.2-0.3-0.1-0.5-0.1-0.10.1-0.0-0.0-0.00.00.0-0.20.30.3
Pavlov. Cond. lever latency0.30.41.8-1.10.80.51.30.50.3-0.30.20.30.3-0.0-0.00.1-0.7-0.9
Pavlov. Cond. magazine entry latency3.24.15.92.4-2.1-2.4-1.7-1.7-2.12.12.02.02.0-2.1-2.12.0-1.8-1.7
Pavlov. Cond. change in total contacts0.10.10.50.7-0.3-0.5-0.4-0.2-0.30.20.20.20.2-0.2-0.20.2-0.0-0.0
Pavlov. Cond. index score0.60.82.41.6-1.1-1.2-1.3-0.8-0.90.80.60.50.5-0.7-0.70.7-0.3-0.1
Pavlov. Cond. latency score0.70.92.91.7-1.2-1.3-1.5-1.0-0.90.80.50.40.4-0.7-0.70.6-0.10.1
Pavlov. Cond. lever contacts0.30.31.31.0-0.6-0.4-1.2-0.4-0.30.2-0.2-0.3-0.30.10.1-0.10.70.8
Pavlov. Cond. magazine entry number0.91.11.9-1.41.11.40.80.81.1-1.0-1.0-1.0-1.01.11.1-1.11.00.9
Pavlov. Cond. intertrial magazine entries0.20.20.8-0.20.1-0.10.60.0-0.20.30.50.60.6-0.4-0.40.6-0.8-0.9
Pavlov. Cond. lever-magazine prob. diff.0.70.92.61.6-1.2-1.3-1.3-0.9-1.00.90.70.60.6-0.9-0.90.8-0.4-0.3
Pavlov. Cond. response bias0.91.12.01.4-1.1-1.4-0.9-0.8-1.11.11.01.01.0-1.1-1.11.1-0.9-0.8
Pavlov. Cond. lever latency0.60.81.2-0.50.70.70.31.10.9-0.9-1.1-1.1-1.10.90.9-1.01.11.0
Pavlov. Cond. magazine entry latency0.30.40.70.6-0.5-0.8-0.3-0.8-0.60.60.70.70.7-0.7-0.70.6-0.7-0.6
Pavlov. Cond. change in total contacts0.30.71.10.2-0.5-0.5-0.1-0.8-0.70.81.01.01.0-0.8-0.81.0-1.1-1.0
Pavlov. Cond. index score0.50.71.10.4-0.6-0.7-0.2-0.9-0.80.81.01.01.0-0.9-0.80.9-1.0-1.0
Pavlov. Cond. latency score0.50.71.10.5-0.7-0.8-0.4-1.0-0.80.91.01.01.0-0.9-0.80.9-1.0-0.9
Pavlov. Cond. lever contacts0.40.61.20.3-0.4-0.5-0.0-0.8-0.70.71.01.01.0-0.8-0.80.9-1.1-1.0
Pavlov. Cond. magazine entry number0.60.71.1-0.80.81.00.51.00.9-0.8-0.9-0.9-0.90.90.9-0.90.90.8
Pavlov. Cond. intertrial magazine entries0.20.51.1-1.00.91.01.00.80.8-0.7-0.6-0.5-0.50.60.6-0.50.20.1
Pavlov. Cond. lever-magazine prob. diff.0.50.81.10.6-0.7-0.8-0.4-1.1-0.90.91.01.01.0-0.9-0.90.9-1.0-0.9
Pavlov. Cond. response bias1.31.83.00.7-0.9-1.1-0.3-1.3-1.31.31.61.61.6-1.4-1.41.5-1.7-1.6
Time in closed arm before self-admin0.30.51.6-0.0-0.00.5-0.60.20.4-0.5-0.8-0.9-0.90.70.7-0.91.21.3
Time in closed arm after self-admin0.20.20.50.0-0.1-0.30.30.0-0.30.30.50.50.5-0.4-0.50.5-0.7-0.7
Time in open arm before self-admin0.10.10.20.4-0.3-0.3-0.4-0.5-0.40.40.50.50.4-0.3-0.30.2-0.3-0.2
Time in open arm after self-admin1.01.11.2-1.01.01.10.80.91.1-1.1-1.1-1.1-1.11.11.1-1.01.00.9
Bone: periosteal estimation0.20.51.4-0.10.20.5-0.3-0.10.5-0.5-0.8-0.9-0.90.70.8-0.91.01.2
Bone: periosteal perimeter0.10.31.00.8-0.7-0.4-1.0-1.0-0.50.50.30.10.1-0.2-0.20.10.10.4
Bone: post-yield work0.50.91.3-1.01.10.91.00.91.1-1.0-1.0-1.0-1.01.01.0-0.90.70.7
Progressive ratio test 1 active lever presses0.20.31.0-0.20.4-0.20.90.40.00.10.40.50.5-0.3-0.30.4-0.8-1.0
Progressive ratio test 1 breakpoint0.10.30.9-0.20.4-0.10.90.40.10.00.40.50.5-0.3-0.30.4-0.8-0.9
Progressive ratio test 1 inactive lever presses0.10.40.80.5-0.3-0.70.1-0.3-0.40.50.70.70.7-0.6-0.60.5-0.8-0.9
Progressive ratio test 2 active lever presses0.30.51.6-0.20.4-0.30.90.3-0.10.30.80.90.9-0.5-0.50.5-1.1-1.3
Progressive ratio test 2 breakpoint0.40.51.8-0.10.3-0.30.90.2-0.20.40.81.01.0-0.6-0.60.6-1.2-1.3
Progressive ratio test 2 inactive lever presses0.10.20.40.5-0.3-0.4-0.1-0.2-0.30.40.60.60.6-0.4-0.40.2-0.4-0.4
Incentive Sensitization - Responses0.10.31.3-0.60.70.31.10.80.4-0.20.20.40.40.10.1-0.1-0.5-0.7
Incentive Sensitization - Breakpoint0.10.20.9-0.40.60.10.90.60.2-0.00.30.50.5-0.0-0.1-0.0-0.5-0.7
Sum of active levers in priming session hrs 5-60.00.00.00.00.10.10.10.20.1-0.1-0.1-0.0-0.10.10.1-0.20.10.2
Progressive ratio0.10.41.6-0.50.70.30.71.30.7-0.6-0.7-0.6-0.60.50.5-0.40.40.1
Food seeking constrained by brief footshock0.30.41.51.2-0.9-0.8-0.9-0.1-0.60.60.40.40.4-0.5-0.60.4-0.1-0.1
Seeking ratio, punishment vs. effort0.20.51.21.1-1.0-0.6-1.1-1.0-0.80.70.60.50.5-0.6-0.60.5-0.2-0.1
Retroperitoneal fat weight0.41.94.0-1.61.71.31.92.01.5-1.5-1.3-1.1-1.11.21.2-1.00.70.4
Reaction time number correct0.31.24.1-1.61.61.22.01.51.1-1.0-0.6-0.4-0.40.70.7-0.4-0.2-0.4
Reaction time mean minus median0.10.61.00.4-0.5-0.8-0.2-0.9-0.70.80.90.90.9-0.8-0.80.9-1.0-1.0
Reaction time mean minus median AUC0.00.10.40.3-0.3-0.1-0.6-0.6-0.1-0.0-0.2-0.3-0.30.10.2-0.30.40.5
Reaction time num false alarms0.30.51.9-1.11.20.61.40.60.7-0.6-0.2-0.2-0.20.40.5-0.2-0.2-0.3
Reaction time num false alarms AUC0.20.62.4-1.21.30.71.50.80.8-0.6-0.2-0.1-0.10.50.5-0.2-0.3-0.4
Reaction time trials correct on left0.31.24.1-1.61.61.22.01.51.1-1.0-0.6-0.4-0.40.70.7-0.4-0.2-0.4
Reaction time trials on left0.31.13.9-1.61.61.22.01.41.1-1.0-0.6-0.4-0.40.70.7-0.4-0.1-0.4
Reaction time mean0.00.10.2-0.2-0.00.2-0.2-0.40.1-0.1-0.2-0.3-0.30.30.3-0.30.40.5
Reaction time mean AUC0.00.10.3-0.30.00.3-0.2-0.40.2-0.2-0.3-0.4-0.40.30.3-0.40.40.5
Median of all reaction times0.30.40.9-0.50.30.6-0.1-0.00.5-0.6-0.7-0.8-0.80.70.7-0.80.90.9
Reaction time omissions0.20.31.00.5-0.9-0.4-1.0-0.8-0.60.50.30.30.3-0.4-0.40.10.00.2
Reaction time false alarm rate0.00.10.2-0.30.50.20.30.10.3-0.2-0.2-0.2-0.20.30.3-0.20.10.1
Reaction time premature initiation rate0.81.22.00.5-0.8-1.0-0.3-0.8-1.01.11.21.31.3-1.2-1.21.3-1.4-1.4
Reaction time premature initiations0.31.03.1-0.3-0.0-0.50.8-0.1-0.50.61.01.21.2-0.9-1.01.2-1.6-1.8
Std. dev. reaction times0.00.10.50.1-0.3-0.3-0.2-0.7-0.30.40.40.30.3-0.3-0.30.3-0.4-0.3
Reaction time trials completed0.31.13.9-1.61.61.22.01.41.1-1.0-0.6-0.4-0.40.70.7-0.4-0.1-0.4
Reaction time trials AUC0.41.24.7-1.71.71.22.21.51.1-1.0-0.5-0.4-0.40.70.7-0.4-0.2-0.5
Run reversals in cocaine runway, females0.60.61.11.1-1.0-1.0-1.1-0.7-0.90.80.70.60.6-0.7-0.70.6-0.4-0.3
Run reversals in cocaine runway, males1.71.93.01.7-1.7-1.5-1.5-1.5-1.51.51.31.21.2-1.4-1.41.3-1.0-0.8
Latency to leave start box in cocaine runway0.50.62.10.7-1.1-0.3-1.5-1.2-0.91.00.70.60.6-0.6-0.60.3-0.10.2
Latency to leave start box in cocaine runway, F0.30.41.80.2-0.70.5-1.3-0.6-0.20.3-0.0-0.2-0.20.30.3-0.60.91.2
Latency to leave start box in cocaine runway, M1.61.62.30.8-0.9-1.2-0.5-1.1-1.21.21.31.41.4-1.4-1.41.4-1.5-1.5
Std. dev. time between licks in bursts0.50.92.20.8-1.0-0.6-1.0-1.5-1.01.01.00.80.8-0.9-0.90.8-0.7-0.5
Total sessions with >9 infusions0.30.30.80.2-0.1-0.40.3-0.3-0.30.50.80.90.9-0.5-0.50.5-0.8-0.9
Short access day 1 total inactive lever presses0.20.40.70.6-0.5-0.7-0.2-0.5-0.60.70.80.80.8-0.7-0.70.6-0.7-0.8
Short access day 10 total inactive lever presses0.00.10.4-0.30.40.10.60.40.2-0.10.20.30.30.00.00.2-0.3-0.4
Short access day 1 total infusions0.20.40.60.7-0.6-0.8-0.3-0.7-0.60.60.70.70.7-0.7-0.70.5-0.7-0.7
Short access day 10 total infusions0.10.20.6-0.00.2-0.20.60.3-0.00.10.40.50.5-0.3-0.30.4-0.6-0.8
Short access total infusions0.30.40.80.4-0.3-0.60.1-0.3-0.40.60.80.90.9-0.6-0.60.6-0.8-0.8
Short access day 1 locomotion1.01.62.31.2-1.0-1.3-0.6-1.2-1.21.31.51.51.5-1.3-1.31.1-1.4-1.3
Short access day 10 total locomotion1.87.310.92.0-1.8-2.6-0.7-2.0-2.52.73.23.33.3-2.8-2.92.9-3.2-3.2
Short access total locomotion1.82.74.31.3-1.1-1.6-0.5-1.4-1.51.72.02.12.1-1.7-1.71.6-1.9-1.9
One hour access (0.3 mA shock)0.00.00.3-0.20.40.10.50.30.2-0.10.10.10.10.10.1-0.0-0.2-0.2
Compulsive drug intake0.81.23.3-0.50.41.0-0.40.20.8-0.9-1.2-1.3-1.31.21.2-1.41.71.8
One hour access (shock baseline)0.30.72.00.3-0.1-0.70.5-0.1-0.50.60.91.01.0-0.8-0.81.0-1.3-1.4
Social response proportion0.91.12.31.2-1.5-1.0-1.4-1.3-1.21.10.90.80.8-1.0-1.00.9-0.5-0.4
Social responses7.09.212.43.3-3.4-3.2-2.9-3.5-3.23.33.13.03.0-3.0-3.02.9-2.4-2.1
Social time0.30.50.8-0.60.50.80.40.90.7-0.7-0.8-0.7-0.70.70.7-0.70.80.7
Soleus weight8.224.227.6-4.95.05.34.04.75.2-5.2-5.1-5.0-5.05.25.2-5.04.54.1
Bone: stiffness2.24.15.1-1.61.82.01.11.52.1-2.1-2.2-2.3-2.32.22.2-2.22.22.1
Tibialis anterior weight1.13.74.2-1.82.02.01.62.02.1-2.0-2.0-2.0-2.02.02.0-1.91.71.6
Time to tail flick, vehicle, before self-admin0.10.10.30.6-0.5-0.4-0.6-0.4-0.30.30.20.20.1-0.2-0.20.20.00.1
Time to tail flick, vehicle, after self-admin0.30.52.00.10.1-0.50.80.1-0.30.30.60.70.7-0.7-0.70.9-1.2-1.4
Time to tail flick, test, before self-admin0.30.41.00.8-0.9-0.6-1.0-0.9-0.70.60.50.40.3-0.5-0.50.4-0.20.0
Time to tail flick, test, after self-admin0.10.10.10.2-0.3-0.4-0.3-0.3-0.30.30.20.20.2-0.3-0.30.3-0.3-0.3
Delta time to tail flick, vehicle, before/after SA0.40.52.3-0.81.10.51.51.10.7-0.6-0.3-0.1-0.10.30.3-0.0-0.4-0.7
Delta time to tail flick, test, before/after SA0.10.20.8-0.40.50.10.90.50.2-0.10.10.20.2-0.1-0.10.3-0.5-0.7
Tibia length0.82.22.91.3-1.3-1.5-0.9-1.4-1.51.61.61.61.6-1.5-1.51.7-1.5-1.4
Ambulatory time before self-admin0.10.20.4-0.30.30.50.10.20.4-0.4-0.4-0.4-0.40.50.5-0.60.60.6
Ambulatory time after self-admin0.00.00.10.3-0.10.0-0.2-0.1-0.00.00.00.00.00.10.1-0.20.20.2
Bone: tissue strength1.71.82.4-1.21.11.40.61.11.3-1.3-1.5-1.5-1.51.51.5-1.51.51.5
Total heroin consumption1.51.82.41.6-1.5-1.5-1.4-1.3-1.51.41.31.31.3-1.4-1.41.3-1.0-0.9
Bone: trabecular number0.50.92.71.5-1.3-1.0-1.6-1.3-1.00.90.60.40.4-0.7-0.60.5-0.00.2
Bone: trabecular spacing0.91.35.6-1.91.71.12.41.71.1-0.9-0.4-0.1-0.10.50.5-0.2-0.5-0.8
Bone: trabecular thickness0.91.35.31.2-1.2-0.0-2.3-1.4-0.40.2-0.4-0.7-0.70.40.4-0.81.62.0
Bone: trabecular tissue density1.11.82.9-1.41.51.41.31.71.5-1.4-1.4-1.3-1.31.41.4-1.31.11.0
Water consumed over 24 hours0.50.91.4-0.70.81.00.30.60.9-0.9-1.0-1.1-1.11.11.1-1.11.11.2
Number of responses in last shaping day1.41.82.80.8-0.9-1.3-0.2-0.9-1.11.31.61.71.7-1.4-1.41.4-1.6-1.7