Hub : Genes

Rdh13

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver isoform ratio XM_039081520.2 0.03 0.03 1.8e-03 0.01 0.02 0.01 0.01 5.2e-02 5.9e-03 5.8e-02 2.9e-02
2 IC gene expression Rdh13 0.07 0.06 7.8e-03 0.01 0.01 -0 -0 1.2e-01 1.6e-01 5.0e-01 3.7e-01
3 Adipose gene expression Rdh13 0.19 0.11 1.2e-15 0.12 0.12 0.12 0.12 1.8e-13 4.2e-13 2.3e-13 9.7e-14
4 Brain gene expression Rdh13 0.02 0.02 5.9e-03 0.01 0.01 0 0.01 1.4e-02 1.3e-02 1.1e-01 2.5e-02
5 NAcc gene expression Rdh13 0.19 0.13 0.0e+00 0.17 0.17 0.17 0.17 8.0e-25 1.1e-25 1.5e-25 1.4e-25
6 Liver gene expression Rdh13 0.08 0.06 5.2e-06 0.03 0.04 0.04 0.04 1.6e-04 3.9e-05 4.5e-05 7.2e-05
7 PL gene expression Rdh13 0.11 0.07 1.4e-14 0.13 0.13 0.13 0.12 1.2e-13 5.9e-14 6.2e-14 1.9e-13
8 BLA gene expression Rdh13 0.07 0.06 1.5e-03 0.05 0.04 0.04 0.04 1.6e-03 2.5e-03 3.0e-03 3.7e-03
9 OFC gene expression Rdh13 0.19 0.13 3.3e-03 0.08 0.06 0.1 0.07 7.3e-03 1.5e-02 2.2e-03 1.0e-02
10 Liver intron excision ratio chr1_78435229_78438629 0.05 0.04 2.7e-03 -0 0.01 0 0 6.1e-01 1.8e-02 1.3e-01 2.4e-01
11 Adipose alternative polyA XM_039081515.2 0.04 0.04 8.9e-03 0.01 0.01 0.01 0.01 2.1e-02 5.4e-02 5.9e-02 5.7e-02
12 Brain intron excision ratio chr1_78418483_78435125 0.03 0.03 9.1e-03 -0 -0 0.01 -0 3.8e-01 4.0e-01 2.2e-02 3.7e-01
13 RMTg alternative polyA XM_039081515.2 0.29 0.16 1.8e-03 0.12 0.08 0.11 0.09 4.9e-04 4.2e-03 6.9e-04 1.9e-03
14 Liver alternative polyA XM_039081515.2 0.05 0.04 2.8e-03 0.03 0.02 0.03 0.02 4.2e-04 2.9e-03 2.5e-04 1.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.00.10.2-0.3-0.3-0.3-0.3-0.3-0.2-0.4-0.4-0.10.3-0.1-0.20.2-0.2
Area under the delay curve0.20.30.70.60.60.70.60.60.60.60.60.9-0.30.3-0.00.30.2
BMI with tail0.41.42.41.21.51.41.41.41.01.41.51.0-1.2-0.21.50.1-0.5
BMI without tail0.20.52.2-0.5-0.3-0.6-0.3-0.3-0.7-0.2-0.1-0.8-0.5-1.01.5-0.9-1.0
Body weight1.04.57.9-2.6-2.4-2.4-2.3-2.3-2.8-2.0-1.6-2.70.2-2.21.4-1.8-1.5
Weight adjusted by age0.60.82.0-0.8-1.0-0.9-1.0-1.0-0.4-1.1-1.4-0.21.30.1-1.20.40.7
Bone surface2.34.27.3-2.5-2.7-2.5-2.4-2.5-2.4-2.3-2.1-2.51.0-1.3-0.8-1.2-0.4
Bone volume1.83.15.4-2.2-2.3-2.1-2.1-2.2-2.1-2.0-1.9-2.01.0-1.2-0.6-0.9-0.6
Breakpoint value in progressive ratio session0.20.30.50.70.70.70.70.70.60.70.60.2-0.40.30.30.30.3
Number of licking bursts0.00.10.10.30.30.30.30.30.30.30.20.1-0.10.20.20.10.1
Context. condit. distance diff. score0.20.20.50.40.40.40.30.30.60.2-0.00.30.40.7-0.60.70.6
Locomotion velocity, session 12.32.56.90.70.50.4-0.00.11.5-0.5-1.01.72.42.6-1.72.62.2
Locomotion distance, session 12.02.56.2-1.3-1.6-1.4-1.7-1.7-0.6-2.0-2.2-0.72.51.1-1.51.11.5
Locomotion velocity, session 20.91.12.60.60.40.60.20.31.1-0.1-0.31.11.21.6-1.51.61.6
Locomotion distance, session 21.21.73.6-1.3-1.5-1.5-1.6-1.6-0.8-1.8-1.9-0.51.80.5-0.90.50.6
Locomotion velocity, session 30.20.21.10.30.10.30.20.20.40.1-0.00.40.30.6-1.10.60.7
Locomotion distance, session 30.40.51.5-0.2-0.5-0.3-0.5-0.40.1-0.6-0.7-0.01.10.8-1.20.81.0
Stereotopy head waving bouts, day 30.30.44.00.30.60.30.40.40.20.40.5-0.3-0.4-0.22.0-0.2-0.3
Stereotopy head waving duration, day 30.30.32.90.30.50.30.40.40.10.40.5-0.3-0.6-0.41.7-0.4-0.4
Locomotion velocity, session 70.20.20.60.0-0.1-0.1-0.2-0.20.3-0.3-0.5-0.00.80.7-0.40.70.8
Locomotion distance, session 70.30.41.10.20.10.1-0.1-0.00.5-0.3-0.50.60.91.0-0.71.00.8
Stereotopy head waving bouts, day 70.40.52.3-0.5-0.4-0.5-0.4-0.4-0.6-0.3-0.1-1.2-0.3-0.71.5-0.7-0.4
Stereotopy head waving duration, day 70.30.31.1-0.5-0.5-0.5-0.4-0.4-0.7-0.3-0.1-1.1-0.2-0.70.9-0.7-0.3
Locomotion velocity, session 80.60.72.00.40.30.30.10.10.8-0.2-0.50.51.11.4-0.91.41.3
Locomotion distance, session 80.30.51.4-0.2-0.2-0.3-0.4-0.40.2-0.6-0.90.11.21.0-0.81.00.9
Degree of sensitization distance0.00.00.1-0.00.1-0.1-0.0-0.00.0-0.0-0.1-0.00.10.10.40.1-0.1
Degree of sensitization stereotypy0.20.20.8-0.3-0.2-0.2-0.1-0.1-0.4-0.00.1-0.8-0.4-0.60.9-0.6-0.4
Conditioned locomotion0.30.31.30.0-0.10.1-0.2-0.20.3-0.3-0.40.10.80.8-1.11.00.9
Cocaine response after cond. corrected1.41.74.61.11.11.31.41.40.51.71.90.8-2.1-1.00.0-0.8-1.4
Cocaine response after cond. not corrected0.40.51.6-0.4-0.4-0.3-0.2-0.2-0.80.10.2-0.3-0.9-1.2-0.3-1.1-1.3
Cocaine response before conditioning5.05.99.8-2.9-2.8-3.1-3.1-3.1-2.4-3.1-3.1-2.42.4-0.3-0.6-0.60.4
Saline control response1.11.47.60.2-0.40.3-0.2-0.20.6-0.5-0.70.31.41.5-2.81.71.9
Bone: connectivity density0.10.11.40.2-0.00.30.20.20.20.20.20.3-0.10.1-1.20.20.3
Bone: cortical apparent density0.81.19.70.1-0.20.0-0.2-0.20.4-0.4-0.61.20.90.9-3.11.10.6
Bone: cortical area0.71.12.1-1.3-1.3-1.3-1.2-1.2-1.2-1.2-1.0-1.50.5-0.70.6-0.7-0.2
Bone: cortical porosity0.50.62.00.70.70.80.80.80.50.91.0-0.2-0.9-0.31.4-0.10.3
Bone: cortical porosity0.50.52.80.20.20.30.40.4-0.10.60.7-0.9-1.0-0.81.7-0.6-0.2
Bone: cortical thickness0.30.50.90.90.80.80.70.71.00.60.50.70.10.80.10.80.7
Bone: cortical thickness0.20.31.4-0.2-0.3-0.2-0.3-0.30.0-0.5-0.60.50.70.5-1.20.50.3
Bone: cortical tissue density0.81.09.50.1-0.20.0-0.1-0.20.4-0.3-0.61.20.90.9-3.11.10.5
Condit. Reinf. active minus inactive responses0.20.20.40.50.40.50.50.50.40.50.5-0.0-0.40.1-0.60.10.2
Condit. Reinf. active-inactive response ratio1.11.22.11.31.21.41.41.41.01.41.40.9-1.10.2-0.70.20.1
Condit. Reinf. active responses0.10.10.6-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.80.1-0.1-0.1-0.10.1
Condit. Reinf. inactive responses2.12.64.3-1.9-1.8-2.0-2.0-2.0-1.5-2.1-2.1-1.91.6-0.30.7-0.30.1
Incentive salience index mean0.10.10.5-0.3-0.3-0.2-0.3-0.3-0.2-0.3-0.2-0.30.2-0.0-0.7-0.00.1
Condit. Reinf. lever presses0.50.71.1-1.0-1.0-1.0-1.1-1.0-0.8-1.1-1.0-0.50.8-0.2-0.3-0.2-0.1
Condit. Reinf. active minus inactive responses2.83.65.7-2.3-2.2-2.3-2.4-2.4-2.1-2.3-2.1-2.31.5-0.60.5-0.90.4
Condit. Reinf. active-inactive response ratio4.35.08.1-2.8-2.6-2.8-2.6-2.6-2.7-2.5-2.2-2.71.0-1.50.9-1.7-0.7
Condit. Reinf. active responses2.23.15.2-2.0-1.9-2.1-2.2-2.2-1.6-2.3-2.1-2.11.90.20.4-0.31.2
Condit. Reinf. inactive responses0.20.32.00.10.10.0-0.2-0.10.3-0.3-0.3-0.40.81.00.20.61.4
Condit. Reinf. lever presses1.11.65.6-1.1-0.8-1.0-0.8-0.8-1.4-0.6-0.2-2.0-0.5-1.42.4-1.6-0.9
Condit. Reinf. lever reinforcers received2.83.96.5-2.3-2.2-2.4-2.5-2.4-1.8-2.6-2.4-2.42.10.10.3-0.41.0
Conditioned reinforcement - actives0.20.41.1-0.7-0.7-0.5-0.5-0.5-0.9-0.4-0.10.1-0.4-1.0-0.1-0.7-1.1
Conditioned reinforcement - inactives1.42.13.9-1.8-1.6-2.0-1.9-1.9-1.6-1.9-1.8-0.81.3-0.5-0.1-0.7-0.5
Conditioned locomotion0.10.20.5-0.4-0.5-0.3-0.3-0.3-0.6-0.2-0.0-0.1-0.3-0.7-0.0-0.5-0.6
Patch foraging indifference point 0 sec0.40.71.70.90.70.90.70.71.10.50.20.80.51.1-0.41.31.1
Patch foraging indifference point AUC0.40.61.11.01.00.91.01.00.91.00.80.7-0.70.20.30.3-0.3
Delay disc. indifference point, 0s delay0.50.61.50.30.30.3-0.1-0.00.7-0.3-0.60.81.21.1-1.11.10.9
Delay disc. indifference point, 16s delay0.91.03.00.60.60.60.90.90.11.21.5-0.0-1.7-0.81.5-0.8-0.6
Delay disc. indifference point, 2s delay0.60.73.00.80.80.90.70.70.90.50.51.70.10.8-0.80.80.5
Delay disc. indifference point, 24s delay0.50.61.30.70.70.70.90.90.41.01.10.3-1.2-0.30.9-0.3-0.1
Delay disc. indifference point, 4s delay0.10.10.2-0.3-0.4-0.3-0.3-0.3-0.4-0.2-0.00.1-0.1-0.30.0-0.3-0.1
Delay disc. indifference point, 8s delay0.10.10.30.30.30.30.30.30.40.20.20.60.10.3-0.30.30.2
Indifference point function ln k3.15.49.7-2.7-2.7-2.7-3.0-3.0-2.2-3.1-3.0-2.22.6-0.1-0.2-0.21.0
Indifference point function log k3.15.49.7-2.7-2.7-2.7-3.0-3.0-2.2-3.1-3.0-2.22.6-0.1-0.2-0.21.0
Patch foraging total patch changes 0 sec0.30.61.60.90.70.90.60.61.10.40.20.80.41.0-0.41.31.0
Patch foraging total patch changes 12 sec0.20.20.50.50.40.60.70.60.40.70.60.3-0.7-0.0-0.10.1-0.3
Patch foraging total patch changes 18 sec0.40.51.00.90.71.00.90.90.90.80.70.5-0.30.5-0.50.60.6
Patch foraging total patch changes 24 sec0.20.31.0-0.2-0.3-0.20.10.1-0.50.30.3-0.4-0.9-0.80.0-0.8-1.0
Patch foraging total patch changes 6 sec0.60.91.61.21.11.21.31.21.11.21.00.8-0.80.30.60.5-0.1
Patch foraging time to switch 0 sec2.14.214.01.31.51.52.12.00.22.63.10.4-3.7-2.01.4-2.1-2.1
Patch foraging water rate 0 sec0.51.13.6-0.6-0.7-0.7-1.0-0.9-0.0-1.2-1.5-0.11.91.1-0.81.11.1
Patch foraging water rate 12 sec1.63.38.1-1.4-1.6-1.7-2.0-1.9-0.7-2.3-2.6-0.92.91.2-1.81.01.9
Patch foraging water rate 18 sec0.81.33.8-0.9-0.8-1.0-1.2-1.2-0.3-1.5-1.7-0.52.01.0-0.90.81.2
Patch foraging water rate 24 sec0.81.12.5-0.9-1.0-0.9-1.2-1.1-0.5-1.3-1.4-0.71.60.7-1.10.51.2
Patch foraging water rate 6 sec4.16.09.6-3.0-3.1-3.0-3.1-3.1-2.8-3.0-2.7-2.91.8-1.0-0.6-1.20.2
Seeking ratio, delayed vs. immediate footshock0.60.72.40.10.10.1-0.3-0.30.6-0.6-0.90.31.51.3-1.21.31.2
Distance traveled before self-admin2.22.89.6-1.0-1.1-1.1-1.7-1.6-0.2-2.1-2.5-0.23.11.4-1.81.51.6
Distance traveled after self-admin1.01.23.60.90.80.80.40.41.40.0-0.40.51.41.8-0.71.81.9
Extensor digitorum longus weight0.31.11.9-1.2-1.0-1.1-0.9-0.9-1.4-0.7-0.5-1.4-0.3-1.31.0-1.3-1.0
Bone: elastic displacement0.60.72.20.91.10.70.70.81.00.60.30.20.20.91.50.90.6
Bone: elastic work0.30.40.9-0.6-0.4-0.8-0.8-0.7-0.4-0.9-1.0-0.41.00.20.80.20.1
Bone: endosteal estimation2.55.48.8-2.9-2.8-2.9-2.7-2.7-3.0-2.4-2.1-2.60.7-2.00.6-1.9-1.4
Bone: endosteal perimeter1.53.35.1-2.3-2.2-2.2-2.2-2.2-2.2-2.0-1.7-2.20.8-1.30.5-1.3-0.7
Epididymis fat weight0.51.65.0-0.3-0.1-0.50.10.1-0.90.50.6-1.0-1.8-1.82.2-1.9-2.0
Delta time in closed arm before/after self-admin0.10.10.60.30.30.30.30.30.30.30.30.8-0.10.2-0.30.1-0.1
Delta time in open arm before/after self-admin1.31.32.4-1.2-1.3-1.2-1.4-1.4-0.9-1.5-1.6-1.51.30.0-0.40.10.5
Diff in mean of infusions in LGA sessions0.40.51.80.0-0.10.0-0.3-0.30.4-0.5-0.60.71.10.9-1.30.80.9
Delay discount exponential model param0.20.20.5-0.5-0.4-0.5-0.5-0.5-0.4-0.5-0.5-0.70.3-0.20.0-0.2-0.2
Extinction: sum of active levers before priming0.10.20.40.40.50.30.30.30.60.1-0.20.10.40.70.10.60.4
Active lever presses in extinction session 60.80.82.7-0.1-0.10.00.30.3-0.60.61.0-0.7-1.6-1.31.3-1.2-1.1
Bone: final force1.62.64.3-2.0-2.0-2.1-2.0-2.0-1.9-1.9-1.8-1.21.0-0.9-0.4-0.9-0.8
Bone: final moment2.03.25.3-2.3-2.2-2.3-2.3-2.3-2.0-2.2-2.1-1.31.3-0.9-0.4-0.8-0.6
Food consumed during 24 hour testing period1.21.72.7-1.6-1.6-1.6-1.6-1.6-1.5-1.6-1.5-1.30.9-0.70.1-0.6-0.5
Glucose1.42.23.81.81.81.71.61.61.91.41.11.9-0.11.4-0.51.40.9
Heart weight1.21.93.5-1.7-1.7-1.6-1.5-1.5-1.9-1.2-0.9-1.80.0-1.40.2-1.4-0.7
Delay discount hyperbolic model param0.20.30.9-0.6-0.5-0.6-0.5-0.5-0.5-0.5-0.6-0.90.3-0.30.1-0.3-0.2
Intermittent access intake day 1-15 change0.30.71.2-1.1-1.0-0.9-1.0-1.0-1.0-1.0-0.8-0.80.5-0.5-0.0-0.4-0.5
Intermittent access intake escalation0.61.22.0-1.4-1.3-1.3-1.3-1.3-1.4-1.2-1.0-1.10.4-0.90.1-0.7-0.7
Intermittent access intake escalation 20.20.20.9-0.3-0.3-0.2-0.5-0.40.0-0.6-0.7-0.10.90.6-0.60.50.5
Intermitt. access day 1 inactive lever presses0.51.72.9-1.6-1.4-1.7-1.4-1.4-1.7-1.2-1.1-1.50.1-1.20.8-1.3-1.0
Intermitt. access day 15 inactive lever presses1.42.95.0-2.1-1.9-2.1-1.8-1.8-2.2-1.6-1.3-2.10.1-1.71.1-1.5-1.3
Intermitt. access escalation Index0.30.41.10.70.81.00.70.70.60.70.80.9-0.50.20.10.6-0.2
Intermittent access day 1 total infusions0.30.51.1-0.9-0.9-0.8-0.8-0.8-1.1-0.6-0.4-0.4-0.1-0.90.1-0.7-0.8
Intermittent access day 15 total infusions0.81.22.4-1.4-1.3-1.2-1.2-1.2-1.6-1.0-0.6-0.8-0.1-1.30.3-1.1-1.2
Intermittent access terminal intake (last 3 days)0.70.91.8-1.3-1.2-1.2-1.1-1.1-1.3-1.0-0.7-0.60.1-1.0-0.0-0.9-1.0
Intermittent access total infusions1.11.42.6-1.5-1.5-1.4-1.3-1.4-1.6-1.2-0.9-0.60.2-1.2-0.1-1.0-1.1
Intermittent access day 1 locomotion0.91.11.9-1.4-1.3-1.3-1.3-1.3-1.4-1.1-1.0-0.50.3-1.0-0.1-0.8-0.9
Intermittent access day 15 total locomotion0.71.42.7-1.4-1.3-1.3-1.6-1.5-1.0-1.7-1.6-0.21.5-0.0-0.60.1-0.1
Intermittent access total locomotion2.32.74.6-2.1-2.1-2.0-2.1-2.1-2.0-2.0-1.8-1.01.1-1.1-0.4-0.8-1.0
Intermittent access standard deviation0.10.30.70.50.40.70.40.40.50.40.40.9-0.00.4-0.70.60.2
Left kidney weight4.018.529.0-5.4-5.3-5.3-5.2-5.2-5.2-4.9-4.4-5.22.3-2.80.5-2.6-1.2
Right kidney weight4.219.030.4-5.4-5.1-5.4-5.1-5.1-5.5-4.7-4.1-5.51.6-3.31.5-3.3-1.9
Cocaine induced anxiety0.71.02.4-1.2-1.2-1.1-1.2-1.2-1.1-1.1-1.0-1.60.6-0.50.1-0.40.1
Post-drug Anxiety0.70.72.9-0.9-0.8-0.9-0.7-0.7-1.0-0.5-0.3-1.7-0.3-0.91.0-0.9-0.3
Baseline Anxiety0.50.60.90.80.90.80.91.00.71.01.00.8-0.80.20.6-0.0-0.3
Tail length2.49.514.9-3.8-3.8-3.9-3.7-3.7-3.7-3.5-3.2-3.71.6-1.9-0.1-1.9-0.8
Length with tail2.510.718.0-4.1-4.1-3.9-3.8-3.8-4.2-3.4-2.9-4.10.9-2.70.5-2.5-1.4
Length without tail1.54.99.8-2.7-2.7-2.2-2.2-2.2-3.1-1.7-1.0-2.8-0.6-2.81.1-2.4-1.8
Times rat made contact with spout0.10.10.40.20.20.20.30.3-0.00.40.5-0.1-0.6-0.40.6-0.5-0.2
Lifetime Intake0.80.91.8-1.3-1.2-1.1-1.1-1.1-1.3-0.9-0.7-0.40.1-1.0-0.2-0.8-1.1
Liver weight, left0.91.42.2-1.5-1.4-1.4-1.4-1.4-1.5-1.3-1.1-1.40.4-1.00.6-0.8-0.6
Liver weight, right0.00.10.7-0.10.1-0.1-0.1-0.1-0.2-0.10.1-0.2-0.1-0.30.9-0.3-0.0
Locomotor activity0.10.20.40.20.40.20.30.30.10.40.50.2-0.6-0.30.7-0.4-0.3
Locomotor testing distance0.20.41.2-0.3-0.2-0.3-0.1-0.1-0.70.10.3-0.3-0.9-1.10.4-1.0-1.0
Locomotor testing rearing0.40.81.4-1.1-1.1-0.9-0.9-0.9-1.2-0.7-0.6-0.9-0.2-1.2-0.0-0.8-1.1
Locomotion in novel chamber0.91.12.41.31.21.51.21.11.31.11.11.5-0.40.5-0.50.90.2
Locomotion in novel chamber post-restriction0.40.61.50.80.70.90.90.90.61.01.01.2-0.8-0.0-0.20.0-0.4
Fecal boli incidents, locomotor time 10.20.30.5-0.6-0.6-0.6-0.6-0.6-0.4-0.7-0.7-0.20.6-0.0-0.5-0.0-0.1
Change in fecal boli incidents, locomotor task2.42.44.61.91.91.91.81.81.91.61.42.1-0.61.1-0.41.10.4
Time >=10cm from walls, locomotor time 10.00.10.20.10.20.10.20.20.00.30.30.1-0.4-0.20.1-0.2-0.4
Bouts of movement, locomotor time 11.01.13.8-0.2-0.1-0.3-0.7-0.60.4-1.0-1.50.31.91.3-1.71.30.8
Total resting periods, locomotor time 10.50.51.50.20.20.1-0.1-0.10.6-0.4-0.80.61.21.1-1.21.10.6
Rest time, locomotor task time 10.81.11.9-1.3-1.3-1.4-1.2-1.2-1.2-1.2-1.2-0.80.5-0.6-0.2-0.6-0.7
Distance moved, locomotor task time 10.81.22.11.41.31.41.31.31.31.21.20.8-0.50.70.40.70.7
Vertical activity count, locomotor time 11.23.05.52.12.02.21.71.72.31.41.12.00.41.9-0.61.91.6
Time >=10cm from walls, locomotor time 20.50.71.21.01.00.91.11.10.81.11.10.7-0.90.10.20.1-0.3
Bouts of movement, locomotor time 20.00.00.0-0.1-0.1-0.2-0.1-0.1-0.2-0.1-0.1-0.10.0-0.1-0.2-0.1-0.2
Total resting periods, locomotor time 20.00.00.2-0.1-0.1-0.2-0.2-0.2-0.1-0.2-0.20.10.20.1-0.50.1-0.1
Rest time, locomotor task time 20.20.20.60.00.0-0.0-0.2-0.20.3-0.3-0.50.40.80.6-0.80.60.4
Distance moved, locomotor task time 20.10.10.20.50.50.50.40.40.40.40.40.1-0.20.20.20.20.3
Vertical activity count, locomotor time 20.10.20.30.50.40.60.40.40.50.30.30.50.20.5-0.20.50.5
Light reinforcement 10.71.77.80.60.10.60.10.11.1-0.2-0.50.91.51.9-2.81.91.9
Light reinforcement 21.32.03.31.61.41.71.41.41.81.20.91.7-0.01.4-1.81.60.9
Bone: marrow area2.55.59.0-2.9-2.8-2.9-2.7-2.7-3.0-2.4-2.1-2.60.7-2.00.8-2.0-1.4
Bone: maximum diameter1.12.03.9-1.7-1.7-1.6-1.5-1.5-1.9-1.3-0.9-2.00.0-1.40.9-1.5-0.8
Bone: maximum force2.44.37.0-2.6-2.6-2.6-2.5-2.5-2.6-2.3-2.1-2.10.9-1.50.1-1.5-1.1
Bone: maximum moment2.74.87.8-2.8-2.7-2.8-2.7-2.7-2.7-2.6-2.3-2.11.2-1.4-0.1-1.4-0.9
Mean time between licks in bursts0.40.91.81.11.21.00.80.91.30.60.41.30.41.10.41.30.6
Mean num. licks in bursts0.10.20.5-0.5-0.5-0.4-0.3-0.4-0.6-0.2-0.1-0.4-0.3-0.70.3-0.7-0.7
Cd content in liver1.61.83.1-1.6-1.8-1.6-1.7-1.7-1.4-1.7-1.6-1.31.2-0.2-1.2-0.30.3
Co content in liver1.21.34.6-0.6-0.9-0.7-1.0-1.0-0.1-1.3-1.50.51.90.9-2.11.10.9
Cu content in liver0.70.92.0-1.1-1.4-1.0-1.1-1.1-1.1-1.0-0.9-0.80.4-0.6-1.2-0.40.0
Fe content in liver0.20.30.6-0.6-0.8-0.6-0.6-0.6-0.6-0.6-0.5-0.50.3-0.3-0.5-0.20.1
K content in liver0.10.10.80.1-0.10.10.00.00.00.00.0-0.2-0.00.1-0.90.20.4
Mg content in liver0.20.20.80.2-0.00.30.30.3-0.10.50.6-0.2-0.9-0.7-0.3-0.4-0.2
Mn content in liver0.20.20.7-0.0-0.10.10.20.1-0.30.30.4-0.9-0.7-0.70.3-0.5-0.1
Na content in liver2.22.34.11.91.72.01.91.91.81.81.71.3-0.90.8-0.41.00.8
Rb content in liver2.12.45.4-1.9-1.9-1.8-1.7-1.7-2.0-1.5-1.3-2.30.3-1.40.4-1.3-0.4
Se content in liver1.41.73.61.41.41.51.71.61.01.81.90.5-1.8-0.30.8-0.2-0.2
Sr content in liver5.54.88.92.62.52.62.22.22.91.81.33.00.22.2-1.52.21.4
Zn content in liver0.60.62.40.50.30.60.80.70.01.01.20.3-1.6-0.90.1-0.8-0.7
Bone: minimum diameter2.64.87.3-2.7-2.7-2.7-2.6-2.7-2.5-2.5-2.3-2.71.3-1.40.7-1.2-0.7
Time in familiar zone, hab. session 12.92.85.3-1.7-1.9-1.8-2.0-2.0-1.2-2.2-2.3-0.42.20.5-1.90.50.7
Time in novel zone, hab. session 12.12.13.41.71.81.81.81.81.51.81.80.7-1.30.31.30.30.2
Total zone transitions, hab. session 11.42.05.9-0.4-0.7-0.5-0.9-0.90.4-1.3-1.70.52.41.8-2.01.82.0
Total locomotion distance, hab. session 10.91.23.4-0.0-0.3-0.2-0.5-0.50.6-0.8-1.10.71.81.6-1.61.61.6
Locomotion velocity, hab. session 10.60.82.3-0.0-0.2-0.1-0.4-0.40.5-0.7-0.90.61.51.3-1.31.31.3
Time in familiar zone, hab. session 22.83.05.4-2.1-2.1-2.0-1.8-1.9-2.3-1.6-1.2-1.9-0.0-1.8-0.1-1.8-1.4
Time in novel zone, hab. session 21.71.83.01.71.71.61.51.51.71.31.11.3-0.31.10.71.10.8
Total zone transitions, hab. session 21.72.14.2-1.4-1.6-1.5-1.8-1.7-0.9-1.9-2.0-1.12.00.6-0.80.61.1
Total locomotion distance, hab. session 20.40.51.40.1-0.00.0-0.2-0.20.5-0.4-0.60.51.21.2-0.81.21.2
Locomotion velocity, hab. session 20.50.71.90.30.10.2-0.0-0.00.7-0.3-0.60.71.31.4-1.01.41.4
Novel to familiar place preference ratio0.10.10.3-0.2-0.2-0.2-0.1-0.1-0.3-0.10.0-0.5-0.2-0.40.6-0.4-0.3
Novelty place preference0.10.10.4-0.4-0.4-0.4-0.4-0.4-0.5-0.3-0.2-0.60.0-0.40.3-0.4-0.2
Time in novel zone, NPP test0.20.20.4-0.5-0.4-0.5-0.4-0.4-0.6-0.3-0.3-0.7-0.1-0.50.1-0.5-0.3
Total zone transitions, NPP test0.40.51.5-0.4-0.6-0.5-0.6-0.6-0.1-0.8-0.90.11.20.7-0.90.70.8
Total locomotion distance, NPP test0.20.30.5-0.6-0.7-0.6-0.6-0.6-0.5-0.7-0.7-0.60.5-0.10.4-0.10.1
Locomotion velocity, NPP test0.20.30.7-0.5-0.7-0.6-0.7-0.7-0.3-0.8-0.8-0.50.90.30.20.30.5
Intraocular pressure0.10.20.60.30.20.30.20.20.40.10.00.50.30.6-0.80.50.5
Delta distance traveled before/after self-admin1.51.62.71.61.51.61.61.61.31.61.70.8-1.20.40.60.40.4
Delta ambulatory time before/after self-admin1.01.22.01.41.41.41.41.41.21.41.40.9-0.80.50.30.50.4
Parametrial fat weight1.33.15.02.02.22.22.12.11.72.12.21.7-1.60.21.40.4-0.5
Pavlov. Cond. lever latency0.10.20.30.40.30.40.40.40.50.30.20.40.10.5-0.60.50.5
Pavlov. Cond. magazine entry latency0.60.81.90.81.10.91.01.00.61.11.20.6-1.1-0.31.4-0.3-0.6
Pavlov. Cond. change in total contacts0.20.20.50.50.50.60.50.50.50.50.50.7-0.20.3-0.40.30.2
Pavlov. Cond. index score0.20.30.40.60.70.60.60.60.50.60.60.6-0.50.00.50.0-0.1
Pavlov. Cond. latency score0.20.20.40.40.50.40.50.50.30.50.60.5-0.5-0.10.6-0.1-0.3
Pavlov. Cond. lever contacts0.30.41.0-0.5-0.4-0.5-0.4-0.4-0.7-0.20.0-0.7-0.5-0.91.0-0.9-0.8
Pavlov. Cond. magazine entry number0.20.30.5-0.4-0.6-0.5-0.6-0.6-0.3-0.6-0.7-0.40.70.3-0.60.30.4
Pavlov. Cond. intertrial magazine entries1.01.23.70.50.30.40.00.11.0-0.3-0.60.61.61.8-1.31.81.9
Pavlov. Cond. lever-magazine prob. diff.0.20.30.50.60.70.60.60.60.40.60.70.5-0.5-0.00.6-0.0-0.2
Pavlov. Cond. response bias0.20.30.9-0.10.10.00.20.1-0.30.30.5-0.2-0.8-0.80.9-0.8-0.8
Pavlov. Cond. lever latency0.50.75.4-0.6-0.9-0.7-0.7-0.7-0.6-0.6-0.7-0.00.4-0.2-2.3-0.2-0.1
Pavlov. Cond. magazine entry latency0.91.03.91.01.20.91.11.10.81.21.10.3-1.1-0.22.0-0.1-0.7
Pavlov. Cond. change in total contacts0.20.43.5-0.3-0.1-0.2-0.4-0.4-0.1-0.5-0.5-0.70.60.21.90.40.4
Pavlov. Cond. index score0.50.67.00.20.60.30.30.30.20.40.4-0.4-0.4-0.32.7-0.1-0.6
Pavlov. Cond. latency score0.60.86.40.71.00.70.80.80.60.80.8-0.0-0.7-0.22.50.0-0.5
Pavlov. Cond. lever contacts0.40.56.20.30.60.40.30.40.30.30.4-0.3-0.3-0.02.50.0-0.0
Pavlov. Cond. magazine entry number0.50.62.4-0.7-0.9-0.8-0.8-0.8-0.6-0.8-0.8-0.50.70.1-1.5-0.10.5
Pavlov. Cond. intertrial magazine entries2.33.45.7-2.2-2.4-2.2-2.3-2.2-2.0-2.2-2.0-2.01.4-0.3-1.5-0.80.5
Pavlov. Cond. lever-magazine prob. diff.0.50.66.50.40.70.40.40.50.40.40.4-0.1-0.4-0.12.60.1-0.5
Pavlov. Cond. response bias0.50.67.5-0.30.0-0.3-0.3-0.2-0.3-0.2-0.2-0.90.0-0.32.7-0.3-0.2
Time in closed arm before self-admin0.60.81.3-1.1-1.2-1.0-1.1-1.1-1.0-1.0-0.9-1.20.6-0.4-0.3-0.50.1
Time in closed arm after self-admin0.10.10.6-0.3-0.4-0.3-0.2-0.2-0.5-0.00.2-0.3-0.5-0.6-0.0-0.8-0.3
Time in open arm before self-admin1.71.93.31.61.71.71.71.71.51.61.51.8-1.00.50.20.7-0.1
Time in open arm after self-admin0.20.20.80.50.60.60.40.40.70.2-0.00.40.40.7-0.00.90.3
Bone: periosteal estimation1.94.06.1-2.5-2.4-2.4-2.4-2.4-2.5-2.2-1.9-2.40.8-1.50.7-1.5-0.8
Bone: periosteal perimeter1.52.53.8-2.0-1.9-2.0-1.9-1.9-1.9-1.8-1.6-2.00.9-0.90.6-0.9-0.3
Bone: post-yield work2.94.37.6-2.5-2.7-2.4-2.2-2.3-2.8-1.9-1.5-2.60.1-2.1-0.5-2.0-1.3
Progressive ratio test 1 active lever presses0.50.61.5-0.8-0.8-0.8-1.0-1.0-0.5-1.1-1.20.01.20.2-0.80.30.1
Progressive ratio test 1 breakpoint0.50.61.5-0.8-0.8-0.9-1.0-1.0-0.5-1.1-1.20.01.10.2-0.70.20.0
Progressive ratio test 1 inactive lever presses1.72.44.4-1.9-1.8-2.1-2.0-2.0-1.7-2.0-1.9-1.01.2-0.6-0.3-0.7-0.5
Progressive ratio test 2 active lever presses0.60.71.5-1.0-0.9-0.8-0.8-0.8-1.2-0.6-0.2-0.6-0.4-1.20.5-1.1-1.0
Progressive ratio test 2 breakpoint0.70.81.7-1.1-1.0-0.9-0.9-0.9-1.3-0.6-0.2-0.8-0.4-1.30.5-1.1-1.1
Progressive ratio test 2 inactive lever presses1.93.15.1-2.3-2.2-2.2-2.2-2.2-2.1-2.1-1.9-1.51.1-1.1-0.1-1.0-0.7
Incentive Sensitization - Responses1.52.14.1-1.7-1.6-1.4-1.3-1.4-2.0-1.0-0.5-1.8-0.5-1.81.0-1.7-1.3
Incentive Sensitization - Breakpoint1.21.63.2-1.4-1.3-1.2-1.1-1.1-1.8-0.8-0.2-1.6-0.7-1.71.1-1.6-1.2
Sum of active levers in priming session hrs 5-60.20.20.50.20.20.20.10.10.4-0.1-0.3-0.10.60.7-0.30.70.6
Progressive ratio0.10.20.60.10.2-0.1-0.0-0.00.4-0.2-0.5-0.20.70.8-0.20.60.8
Food seeking constrained by brief footshock3.74.513.60.60.60.2-0.4-0.41.8-1.2-2.21.43.73.4-2.63.22.9
Seeking ratio, punishment vs. effort0.40.61.9-0.6-0.6-0.6-0.9-0.9-0.3-1.1-1.10.01.40.5-1.00.50.5
Retroperitoneal fat weight3.012.922.53.94.44.04.54.43.04.74.73.1-4.2-0.32.6-0.2-1.6
Reaction time number correct0.10.20.50.50.60.40.40.50.60.30.30.70.10.50.60.40.2
Reaction time mean minus median0.00.10.5-0.1-0.10.0-0.1-0.1-0.1-0.1-0.10.5-0.0-0.40.10.1-0.7
Reaction time mean minus median AUC0.00.10.6-0.0-0.10.10.10.0-0.10.10.20.3-0.4-0.5-0.1-0.2-0.8
Reaction time num false alarms0.00.00.1-0.0-0.20.1-0.1-0.1-0.0-0.1-0.00.30.1-0.0-0.10.20.3
Reaction time num false alarms AUC0.30.41.20.50.20.70.30.30.70.20.11.00.50.8-0.81.10.9
Reaction time trials correct on left0.10.20.50.50.60.40.40.50.60.30.30.70.10.50.60.40.2
Reaction time trials on left0.10.20.60.50.60.40.40.50.60.30.20.70.10.50.60.40.2
Reaction time mean0.50.91.5-1.1-1.2-1.0-0.9-1.0-1.2-0.8-0.6-0.7-0.1-1.2-0.1-0.9-1.1
Reaction time mean AUC0.30.51.6-0.7-0.8-0.6-0.5-0.6-1.0-0.3-0.2-0.4-0.5-1.3-0.0-0.9-1.3
Median of all reaction times0.60.81.6-1.1-1.1-1.1-0.9-0.9-1.3-0.7-0.5-0.9-0.2-1.2-0.0-1.0-1.0
Reaction time omissions0.30.42.10.3-0.10.40.10.00.6-0.1-0.30.80.80.8-1.51.10.6
Reaction time false alarm rate0.20.20.90.2-0.00.40.10.00.4-0.1-0.10.50.50.6-1.00.80.8
Reaction time premature initiation rate0.10.10.3-0.2-0.4-0.3-0.1-0.2-0.4-0.0-0.1-0.1-0.4-0.5-0.5-0.4-0.3
Reaction time premature initiations0.00.10.30.1-0.00.00.20.2-0.10.30.20.3-0.5-0.40.2-0.3-0.4
Std. dev. reaction times0.30.61.2-0.9-1.1-0.8-0.8-0.8-1.0-0.7-0.5-0.4-0.1-1.1-0.2-0.7-1.1
Reaction time trials completed0.10.20.60.50.60.40.40.50.60.30.20.70.10.50.60.40.2
Reaction time trials AUC0.10.20.50.40.50.40.40.40.50.30.30.6-0.10.30.70.20.0
Run reversals in cocaine runway, females0.50.51.5-0.7-0.8-0.6-0.5-0.5-0.9-0.3-0.1-0.9-0.5-1.20.3-0.9-0.5
Run reversals in cocaine runway, males0.00.00.3-0.1-0.1-0.2-0.1-0.1-0.2-0.0-0.00.2-0.2-0.4-0.2-0.2-0.5
Latency to leave start box in cocaine runway0.30.40.7-0.7-0.9-0.8-0.7-0.7-0.7-0.7-0.7-0.60.4-0.3-0.4-0.3-0.5
Latency to leave start box in cocaine runway, F0.10.10.3-0.2-0.3-0.3-0.2-0.2-0.2-0.2-0.3-0.00.1-0.2-0.4-0.1-0.6
Latency to leave start box in cocaine runway, M1.11.01.7-1.3-1.3-1.1-1.3-1.3-1.2-1.2-0.8-1.10.6-0.6-0.1-0.7-0.2
Std. dev. time between licks in bursts1.01.44.30.70.70.50.20.31.4-0.2-0.51.11.62.0-0.22.11.8
Total sessions with >9 infusions0.60.81.4-1.1-1.1-0.9-1.2-1.2-0.9-1.2-1.2-0.20.9-0.3-0.60.1-0.2
Short access day 1 total inactive lever presses0.71.02.1-1.2-1.1-1.1-0.9-0.9-1.4-0.7-0.4-0.9-0.4-1.30.5-1.2-0.9
Short access day 10 total inactive lever presses0.10.20.4-0.6-0.5-0.6-0.5-0.5-0.6-0.5-0.4-0.30.1-0.30.0-0.4-0.2
Short access day 1 total infusions0.00.00.3-0.1-0.0-0.0-0.1-0.1-0.0-0.1-0.10.60.1-0.0-0.20.1-0.2
Short access day 10 total infusions0.00.10.50.10.20.20.10.10.20.10.00.70.10.1-0.40.2-0.2
Short access total infusions0.10.11.00.20.30.30.20.20.20.20.21.0-0.10.0-0.40.2-0.4
Short access day 1 locomotion0.30.40.8-0.8-0.8-0.7-0.7-0.7-0.9-0.5-0.4-0.1-0.1-0.90.0-0.6-0.9
Short access day 10 total locomotion0.61.13.3-0.8-0.8-0.8-1.1-1.1-0.3-1.4-1.60.21.80.7-1.30.80.6
Short access total locomotion0.60.82.5-0.3-0.4-0.3-0.7-0.70.2-0.9-1.10.91.60.8-1.41.10.5
One hour access (0.3 mA shock)3.13.56.1-2.5-2.4-2.2-2.3-2.3-2.4-2.1-1.8-1.80.8-1.50.1-1.2-1.1
Compulsive drug intake1.61.93.4-1.7-1.5-1.7-1.6-1.6-1.6-1.5-1.4-1.90.8-0.80.9-0.8-0.4
One hour access (shock baseline)0.30.51.2-0.7-0.7-0.6-0.5-0.5-1.0-0.3-0.0-0.2-0.6-1.10.1-1.0-1.1
Social response proportion0.91.01.9-1.1-1.1-1.1-0.9-0.9-1.4-0.7-0.4-1.0-0.4-1.40.3-1.3-1.0
Social responses2.12.74.5-2.1-2.1-2.0-2.0-2.0-2.0-1.8-1.7-2.00.8-1.0-0.3-1.1-0.2
Social time2.53.46.5-1.9-1.9-2.0-2.3-2.2-1.4-2.5-2.5-1.42.50.5-0.90.31.3
Soleus weight0.00.10.3-0.4-0.5-0.3-0.3-0.4-0.5-0.3-0.2-0.5-0.1-0.4-0.4-0.3-0.3
Bone: stiffness2.13.35.5-2.3-2.4-2.3-2.2-2.2-2.2-2.1-1.9-1.80.9-1.3-0.2-1.2-0.9
Tibialis anterior weight0.62.14.31.21.51.41.61.60.71.82.00.7-2.0-0.72.1-0.8-0.9
Time to tail flick, vehicle, before self-admin0.40.51.3-0.5-0.5-0.6-0.7-0.7-0.2-0.9-1.1-0.31.10.5-0.80.50.4
Time to tail flick, vehicle, after self-admin0.40.51.1-0.8-0.8-0.8-0.6-0.6-1.0-0.4-0.2-0.7-0.4-0.90.4-1.0-0.7
Time to tail flick, test, before self-admin1.01.02.90.50.40.50.10.11.0-0.3-0.61.41.41.5-1.71.51.2
Time to tail flick, test, after self-admin0.20.20.50.50.50.50.60.60.30.60.70.0-0.7-0.10.5-0.1-0.2
Delta time to tail flick, vehicle, before/after SA0.40.31.20.0-0.00.00.30.3-0.40.50.80.2-1.1-0.90.5-1.0-0.6
Delta time to tail flick, test, before/after SA0.60.61.6-0.4-0.3-0.4-0.1-0.1-0.70.20.4-1.2-1.0-1.01.3-1.1-0.7
Tibia length2.98.113.1-3.5-3.4-3.5-3.3-3.3-3.5-3.0-2.6-3.61.0-2.31.1-2.2-1.3
Ambulatory time before self-admin1.42.16.6-1.1-1.1-1.1-1.6-1.5-0.4-1.9-2.2-0.62.61.0-1.41.11.4
Ambulatory time after self-admin0.91.13.70.20.10.2-0.3-0.30.8-0.6-1.0-0.11.81.5-0.81.61.9
Bone: tissue strength0.80.83.7-0.2-0.3-0.3-0.5-0.50.2-0.7-0.90.71.41.1-1.91.01.1
Total heroin consumption0.10.10.20.20.30.10.10.20.40.0-0.2-0.10.30.40.20.40.3
Bone: trabecular number0.10.20.60.50.40.50.40.40.60.40.30.80.00.4-0.30.60.3
Bone: trabecular spacing0.10.10.5-0.10.1-0.10.00.0-0.20.10.2-0.2-0.3-0.30.7-0.5-0.4
Bone: trabecular thickness0.00.00.4-0.1-0.2-0.0-0.0-0.1-0.1-0.0-0.10.0-0.1-0.3-0.70.0-0.3
Bone: trabecular tissue density0.60.92.10.91.00.91.11.10.51.31.30.2-1.5-0.60.1-0.4-0.9
Water consumed over 24 hours0.60.81.7-1.0-1.0-1.1-1.2-1.1-0.7-1.2-1.3-0.41.20.1-0.40.20.2
Number of responses in last shaping day0.10.20.8-0.1-0.1-0.10.10.1-0.30.20.20.3-0.6-0.60.2-0.5-0.9