Rbp4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	Rbp4	0.03	0.02	3.3e-03	0	0.01	-0	0	1.2e-01	5.7e-02	7.8e-01	2.1e-01
2	NAcc	gene expression	Rbp4	0.14	0.05	0.0e+00	0.15	0.14	0.13	0.14	7.5e-22	2.5e-20	1.4e-19	2.9e-21
3	Eye	gene expression	Rbp4	0.37	0.13	3.4e-04	0.15	0.12	0.06	0.1	2.8e-03	7.5e-03	4.3e-02	1.1e-02
4	Adipose	gene expression	Rbp4	0.15	0.05	7.5e-15	0.11	0.11	0.12	0.12	7.8e-12	1.7e-12	2.8e-13	3.9e-13
5	Liver	gene expression	Rbp4	0.07	0.04	2.1e-03	0.01	0.02	0	0.01	3.1e-02	9.3e-04	1.7e-01	6.3e-02
6	Brain	gene expression	Rbp4	0.36	0.1	0.0e+00	0.26	0.24	0.25	0.24	9.3e-24	1.2e-22	4.1e-23	2.1e-22

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	3.5	6.0	8.9	3.0	2.7	-2.5	2.9	-1.3	1.9
Area under the delay curve	0.3	0.4	1.6	-0.2	-0.3	0.7	0.2	-0.3	1.2
BMI with tail	0.4	1.4	2.6	0.9	0.7	-1.4	1.2	-1.6	1.0
BMI without tail	0.0	0.1	0.2	-0.3	-0.5	-0.3	-0.5	0.2	-0.4
Body weight	0.2	0.7	2.4	0.6	0.2	-0.7	-0.1	1.5	-0.9
Weight adjusted by age	1.0	1.4	4.3	0.7	0.4	0.0	1.1	-1.6	2.1
Bone surface	2.5	4.6	8.3	2.5	2.4	-2.9	2.2	-1.1	1.1
Bone volume	2.5	4.5	7.3	2.7	2.5	-2.5	2.3	-0.8	1.1
Breakpoint value in progressive ratio session	0.3	0.4	1.8	-0.3	-0.3	-0.0	-0.4	1.3	-0.2
Number of licking bursts	0.8	1.2	2.6	-1.0	-1.1	1.4	-0.5	-0.6	1.6
Context. condit. distance diff. score	1.1	1.4	2.5	1.6	1.4	-1.3	1.3	0.6	0.0
Locomotion velocity, session 1	1.5	1.6	3.0	-1.6	-1.2	1.7	-0.8	-1.2	0.8
Locomotion distance, session 1	0.5	0.7	1.6	-0.9	-1.0	1.3	-0.5	-0.2	0.7
Locomotion velocity, session 2	0.5	0.6	1.1	-0.0	0.8	-1.0	0.6	-1.0	0.5
Locomotion distance, session 2	0.1	0.1	0.2	-0.4	-0.2	-0.3	-0.3	0.2	0.4
Locomotion velocity, session 3	0.1	0.2	0.4	0.4	0.7	-0.1	0.3	0.4	-0.3
Locomotion distance, session 3	0.9	0.9	2.7	0.3	0.6	-0.1	-0.0	1.7	-1.6
Stereotopy head waving bouts, day 3	0.8	1.0	2.6	0.5	0.6	-0.0	0.8	-1.6	1.4
Stereotopy head waving duration, day 3	1.2	1.5	3.8	0.8	0.5	-0.3	1.0	-1.8	1.9
Locomotion velocity, session 7	1.7	1.9	3.6	1.8	1.9	-1.7	1.2	0.1	0.0
Locomotion distance, session 7	1.2	1.5	3.3	1.4	1.5	-1.8	0.7	0.6	-0.7
Stereotopy head waving bouts, day 7	0.5	0.6	1.3	0.1	0.4	0.6	0.8	-1.0	1.1
Stereotopy head waving duration, day 7	0.5	0.6	1.5	0.4	0.5	0.5	0.8	-1.2	0.8
Locomotion velocity, session 8	0.2	0.2	0.4	0.6	0.5	-0.5	0.5	0.0	0.1
Locomotion distance, session 8	0.7	1.0	2.0	1.0	1.1	-1.4	1.2	0.3	0.7
Degree of sensitization distance	0.4	0.4	1.2	0.6	0.4	-1.1	0.4	-0.4	0.8
Degree of sensitization stereotypy	0.2	0.2	0.9	-0.4	-0.2	0.9	0.3	0.0	0.1
Conditioned locomotion	0.1	0.1	0.2	0.4	0.1	-0.3	-0.1	0.1	-0.4
Cocaine response after cond. corrected	0.2	0.2	0.3	-0.5	-0.6	0.0	-0.5	0.4	-0.4
Cocaine response after cond. not corrected	0.2	0.2	0.8	-0.3	-0.4	0.0	-0.4	0.9	-0.5
Cocaine response before conditioning	0.1	0.1	0.2	0.1	0.2	0.5	0.1	0.5	0.1
Saline control response	1.3	1.8	3.9	-1.2	-1.5	2.0	-0.8	1.5	0.2
Bone: connectivity density	4.8	7.5	9.3	3.0	3.0	-3.0	3.0	-2.1	2.0
Bone: cortical apparent density	0.4	0.6	1.2	-0.5	-0.6	0.8	0.1	-1.1	0.9
Bone: cortical area	0.8	1.2	3.0	1.2	0.9	-0.9	0.1	1.7	-1.1
Bone: cortical porosity	1.5	1.6	2.2	1.2	1.3	-1.5	1.4	-0.9	1.2
Bone: cortical porosity	1.0	1.1	2.1	1.1	1.4	-1.4	1.1	-0.4	0.5
Bone: cortical thickness	1.4	2.3	5.1	-1.0	-1.3	1.5	-1.5	2.3	-1.2
Bone: cortical thickness	1.2	1.4	3.0	-1.2	-1.4	1.7	-1.1	1.0	0.1
Bone: cortical tissue density	0.5	0.7	1.6	-0.5	-0.6	0.8	0.2	-1.3	1.1
Condit. Reinf. active minus inactive responses	0.3	0.3	0.4	-0.6	-0.2	0.5	-0.6	0.6	-0.7
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.7	-0.8	-0.3	0.3	-0.5	0.1	-0.8
Condit. Reinf. active responses	0.5	0.6	1.7	-0.4	-0.3	0.5	-0.7	1.3	-0.9
Condit. Reinf. inactive responses	0.2	0.2	1.0	0.2	-0.2	0.4	-0.3	1.0	-0.2
Incentive salience index mean	1.2	1.5	2.5	-1.3	-1.0	1.0	-1.3	1.6	-1.2
Condit. Reinf. lever presses	2.1	2.9	3.8	-2.0	-1.9	1.7	-1.8	1.6	-1.1
Condit. Reinf. active minus inactive responses	1.9	2.5	4.1	2.0	1.8	-1.7	1.8	-0.6	0.9
Condit. Reinf. active-inactive response ratio	1.7	2.0	2.7	1.6	1.3	-1.4	1.6	-1.1	1.2
Condit. Reinf. active responses	0.3	0.4	1.2	1.1	0.6	-0.3	0.6	0.5	-0.1
Condit. Reinf. inactive responses	1.7	2.2	3.6	-0.9	-1.2	1.6	-1.4	1.9	-1.6
Condit. Reinf. lever presses	0.2	0.3	0.9	-0.5	-0.5	0.9	-0.4	0.3	-0.0
Condit. Reinf. lever reinforcers received	0.2	0.2	0.6	0.8	0.4	-0.0	0.5	0.5	0.0
Conditioned reinforcement - actives	0.2	0.3	0.6	0.3	0.6	-0.1	0.5	0.8	-0.6
Conditioned reinforcement - inactives	0.7	1.0	2.3	1.1	1.4	-0.7	1.5	0.2	-0.1
Conditioned locomotion	0.1	0.1	0.3	0.1	0.1	0.5	0.2	0.4	-0.5
Patch foraging indifference point 0 sec	0.8	1.4	2.1	-1.3	-1.1	1.4	-1.5	0.8	-0.9
Patch foraging indifference point AUC	2.6	3.7	5.3	-2.0	-2.3	2.2	-1.9	1.9	-0.6
Delay disc. indifference point, 0s delay	2.2	2.4	3.7	1.6	1.7	-1.1	1.8	-1.1	1.9
Delay disc. indifference point, 16s delay	0.2	0.2	0.4	-0.5	-0.4	0.6	-0.1	0.4	0.5
Delay disc. indifference point, 2s delay	1.1	1.3	4.0	0.5	0.2	-0.3	0.8	-1.6	2.0
Delay disc. indifference point, 24s delay	0.9	1.0	1.6	-1.1	-1.0	1.3	-0.9	1.1	-0.4
Delay disc. indifference point, 4s delay	0.3	0.3	1.3	-0.1	-0.3	0.5	0.2	0.0	1.1
Delay disc. indifference point, 8s delay	1.1	1.3	2.9	-1.2	-1.2	1.7	-0.8	-0.4	1.1
Indifference point function ln k	2.2	3.8	6.3	2.2	2.5	-2.5	1.9	-1.3	0.2
Indifference point function log k	2.2	3.8	6.3	2.2	2.5	-2.5	1.9	-1.3	0.2
Patch foraging total patch changes 0 sec	0.7	1.4	2.1	-1.3	-1.1	1.4	-1.4	0.8	-1.0
Patch foraging total patch changes 12 sec	3.3	4.3	8.0	-2.5	-2.5	2.8	-2.1	0.9	-0.3
Patch foraging total patch changes 18 sec	0.6	0.9	1.6	-1.2	-1.2	1.3	-0.9	0.0	0.5
Patch foraging total patch changes 24 sec	1.0	1.8	2.9	-1.2	-1.0	1.3	-1.5	1.7	-1.1
Patch foraging total patch changes 6 sec	4.1	6.3	9.3	-2.9	-2.7	3.1	-2.8	1.8	-1.4
Patch foraging time to switch 0 sec	0.4	0.8	1.2	-1.0	-1.1	1.1	-0.6	-0.6	1.0
Patch foraging water rate 0 sec	0.5	1.1	2.4	1.1	1.6	-1.3	0.9	-0.1	-0.6
Patch foraging water rate 12 sec	0.2	0.5	1.6	0.4	0.8	-0.5	0.0	0.5	-1.3
Patch foraging water rate 18 sec	0.6	0.9	2.0	1.0	1.4	-1.2	0.7	0.4	-0.8
Patch foraging water rate 24 sec	0.4	0.6	1.0	1.0	1.0	-0.9	0.4	0.6	-0.6
Patch foraging water rate 6 sec	0.1	0.1	0.2	0.3	0.4	-0.5	0.3	-0.4	-0.2
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	1.4	-0.5	-0.2	0.4	-0.4	1.2	-0.6
Distance traveled before self-admin	0.5	0.6	1.5	0.5	1.2	-1.2	0.7	-0.4	0.1
Distance traveled after self-admin	3.1	3.8	4.3	1.6	1.9	-2.0	2.0	-2.1	2.0
Extensor digitorum longus weight	0.2	1.0	1.6	1.3	0.8	-1.2	0.6	1.2	-0.3
Bone: elastic displacement	1.9	2.2	8.9	0.1	0.4	0.1	0.8	-3.0	1.9
Bone: elastic work	2.1	2.7	8.5	0.8	1.2	-0.6	1.4	-2.9	1.9
Bone: endosteal estimation	3.3	7.2	14.0	3.4	3.4	-3.7	2.4	-0.4	0.2
Bone: endosteal perimeter	3.2	6.8	11.9	3.4	3.3	-3.5	2.4	-0.7	0.6
Epididymis fat weight	0.7	2.5	4.2	2.0	1.6	-1.5	1.7	-1.3	1.2
Delta time in closed arm before/after self-admin	1.1	1.0	1.7	-0.9	-0.9	0.8	-1.3	0.9	-1.1
Delta time in open arm before/after self-admin	2.0	2.0	2.6	1.1	1.4	-1.6	1.4	-1.4	1.4
Diff in mean of infusions in LGA sessions	0.8	1.0	1.9	1.3	1.4	-1.2	0.8	-0.3	0.1
Delay discount exponential model param	0.3	0.3	1.2	0.3	0.4	-0.7	-0.0	0.2	-1.1
Extinction: sum of active levers before priming	0.9	1.0	3.4	-0.4	-0.4	-0.1	-0.9	1.8	-1.3
Active lever presses in extinction session 6	4.3	4.3	6.5	2.2	2.1	-2.5	2.3	-0.7	2.0
Bone: final force	0.5	0.7	2.9	0.3	0.1	-0.5	-0.5	1.7	-1.0
Bone: final moment	0.3	0.5	1.8	0.3	0.1	-0.4	-0.6	1.3	-1.0
Food consumed during 24 hour testing period	0.6	0.8	1.2	-0.8	-0.5	0.8	-1.1	0.8	-1.1
Glucose	0.3	0.5	1.8	0.0	0.2	-0.1	-0.5	0.9	-1.3
Heart weight	0.8	1.2	2.9	-0.9	-1.0	0.5	-1.6	0.0	-1.7
Delay discount hyperbolic model param	0.3	0.4	1.5	0.2	0.3	-0.6	-0.1	0.5	-1.2
Intermittent access intake day 1-15 change	0.8	1.7	3.6	1.3	1.8	-1.9	1.2	-0.1	-0.6
Intermittent access intake escalation	1.2	2.6	4.7	1.7	2.2	-2.1	1.7	-0.3	-0.3
Intermittent access intake escalation 2	3.0	3.4	6.8	1.8	2.6	-2.4	1.9	-0.9	0.0
Intermitt. access day 1 inactive lever presses	0.2	0.7	1.7	0.4	0.6	-0.6	0.8	-1.3	0.9
Intermitt. access day 15 inactive lever presses	0.4	0.9	1.8	1.3	1.1	-0.3	1.3	-0.7	0.3
Intermitt. access escalation Index	0.2	0.3	1.1	0.5	0.7	-0.2	0.3	-1.1	-0.2
Intermittent access day 1 total infusions	0.4	0.7	1.7	1.1	0.9	-0.3	1.3	-0.1	0.5
Intermittent access day 15 total infusions	1.4	2.1	3.6	1.8	1.9	-1.5	1.6	0.4	-1.0
Intermittent access terminal intake (last 3 days)	1.5	2.0	3.9	1.8	2.0	-1.3	1.8	-0.1	-0.5
Intermittent access total infusions	0.9	1.0	2.0	1.4	1.3	-0.6	1.4	0.1	-0.2
Intermittent access day 1 locomotion	0.2	0.3	0.7	0.8	0.4	-0.6	0.9	0.0	0.1
Intermittent access day 15 total locomotion	0.1	0.1	0.3	0.3	0.0	0.2	0.5	0.5	-0.1
Intermittent access total locomotion	0.6	0.7	1.6	1.1	0.7	-0.5	1.3	-0.0	0.7
Intermittent access standard deviation	0.9	2.0	3.5	1.3	1.8	-1.9	1.0	0.7	-1.3
Left kidney weight	0.4	1.8	5.1	-0.5	-0.9	0.7	-1.1	2.3	-1.8
Right kidney weight	1.0	4.5	8.6	-1.6	-1.9	1.8	-2.1	2.9	-2.2
Cocaine induced anxiety	1.6	2.2	2.8	1.6	1.7	-1.6	1.6	-1.3	1.1
Post-drug Anxiety	0.1	0.1	0.5	0.5	0.1	-0.3	-0.1	-0.7	0.1
Baseline Anxiety	1.9	2.2	3.9	-1.3	-1.7	1.4	-2.0	1.1	-1.3
Tail length	0.4	1.6	6.4	0.0	-0.1	0.4	-0.9	2.5	-1.5
Length with tail	0.6	2.7	11.4	0.1	-0.2	0.5	-0.9	3.4	-1.9
Length without tail	0.4	1.3	4.6	1.3	0.7	-0.8	0.5	2.1	-0.7
Times rat made contact with spout	0.7	0.8	2.1	0.7	0.8	-0.1	0.7	-1.0	1.4
Lifetime Intake	0.7	0.8	1.8	1.3	1.0	-0.4	1.3	0.1	0.1
Liver weight, left	0.8	1.3	3.5	-0.4	-0.8	0.3	-1.0	1.9	-1.5
Liver weight, right	0.2	0.4	0.9	0.9	0.7	-0.8	0.3	0.6	-0.3
Locomotor activity	0.2	0.4	0.9	-0.0	0.7	-0.3	0.6	-1.0	0.6
Locomotor testing distance	0.2	0.4	1.0	-0.2	0.6	-0.2	0.5	-1.0	0.7
Locomotor testing rearing	0.6	1.2	2.2	1.0	1.4	-1.3	1.5	-0.1	0.7
Locomotion in novel chamber	3.8	4.9	6.4	2.3	2.5	-2.5	2.5	-1.6	1.6
Locomotion in novel chamber post-restriction	0.5	0.7	4.0	-0.1	-0.7	-0.0	-0.1	2.0	-0.2
Fecal boli incidents, locomotor time 1	1.0	1.5	2.9	1.3	1.3	-1.2	1.7	-0.4	0.9
Change in fecal boli incidents, locomotor task	1.4	1.4	1.8	-1.3	-1.3	1.3	-1.2	1.0	-0.9
Time >=10cm from walls, locomotor time 1	4.0	4.2	13.1	-0.4	0.0	-0.1	-1.2	3.6	-3.2
Bouts of movement, locomotor time 1	0.2	0.2	0.6	0.2	0.0	0.4	0.5	0.1	0.8
Total resting periods, locomotor time 1	0.2	0.2	0.5	0.1	-0.1	0.6	0.4	0.4	0.7
Rest time, locomotor task time 1	0.9	1.1	3.1	0.5	0.5	-0.1	1.3	-1.0	1.7
Distance moved, locomotor task time 1	1.7	2.5	5.2	-1.1	-0.9	0.9	-1.7	2.0	-2.3
Vertical activity count, locomotor time 1	0.9	2.1	5.1	-1.1	-1.1	0.3	-1.8	1.4	-2.3
Time >=10cm from walls, locomotor time 2	0.6	0.8	2.6	-0.0	0.6	-0.2	-0.1	1.6	-1.4
Bouts of movement, locomotor time 2	0.5	0.8	1.6	-1.2	-0.8	1.2	-0.4	-0.3	1.1
Total resting periods, locomotor time 2	0.5	0.8	1.7	-1.2	-0.7	1.3	-0.5	-0.0	1.0
Rest time, locomotor task time 2	0.3	0.3	0.7	-0.2	-0.5	0.6	-0.0	0.7	0.9
Distance moved, locomotor task time 2	0.5	0.6	2.5	0.2	0.6	-0.4	-0.3	0.7	-1.6
Vertical activity count, locomotor time 2	0.3	0.4	1.3	-0.2	0.5	-0.7	-0.3	-0.3	-1.1
Light reinforcement 1	0.2	0.5	1.7	-0.1	-0.5	0.6	0.3	-0.5	1.3
Light reinforcement 2	1.1	1.7	3.6	-0.7	-0.9	1.2	0.0	-1.9	1.9
Bone: marrow area	3.5	7.6	14.5	3.5	3.5	-3.8	2.5	-0.5	0.3
Bone: maximum diameter	4.3	8.0	14.3	3.8	3.5	-3.5	2.9	-0.2	0.6
Bone: maximum force	0.5	1.0	2.0	1.4	1.1	-1.2	0.8	0.7	-0.1
Bone: maximum moment	0.5	0.8	1.8	1.4	1.1	-1.1	0.7	0.4	-0.1
Mean time between licks in bursts	0.5	1.1	2.6	-1.1	-0.7	1.0	-1.2	0.1	-1.6
Mean num. licks in bursts	1.1	1.7	3.0	1.6	1.7	-1.7	1.1	-0.2	-0.6
Cd content in liver	1.0	1.1	1.8	-1.3	-1.2	1.3	-1.1	-0.2	-0.7
Co content in liver	1.8	2.1	4.3	-1.5	-1.6	2.1	-1.5	-0.2	-1.1
Cu content in liver	2.6	3.1	6.1	-2.2	-2.2	2.5	-1.6	-0.5	0.6
Fe content in liver	1.5	1.8	3.3	-1.8	-1.6	1.7	-1.4	0.5	-0.4
K content in liver	0.1	0.1	0.3	-0.4	-0.1	-0.1	0.2	0.5	0.4
Mg content in liver	0.1	0.2	0.5	-0.7	-0.5	0.1	-0.3	0.2	0.1
Mn content in liver	0.9	1.0	1.8	-1.0	-1.3	1.2	-0.1	-0.7	1.3
Na content in liver	0.5	0.5	1.1	-1.1	-1.0	0.6	-0.5	0.7	0.1
Rb content in liver	0.1	0.1	0.4	0.3	0.3	0.2	-0.1	0.5	-0.6
Se content in liver	11.6	13.7	27.1	-5.2	-4.8	4.2	-3.7	0.1	-0.0
Sr content in liver	0.2	0.2	0.4	-0.7	-0.4	0.3	-0.2	-0.4	-0.2
Zn content in liver	1.3	1.5	3.8	-1.9	-1.5	1.2	-1.2	-0.0	0.1
Bone: minimum diameter	4.0	7.2	12.5	3.5	3.5	-3.5	2.2	0.5	-1.0
Time in familiar zone, hab. session 1	1.2	1.2	2.6	0.7	0.5	-0.5	1.1	-1.6	1.5
Time in novel zone, hab. session 1	0.5	0.5	1.0	-0.7	-0.5	0.5	-0.6	1.0	-0.7
Total zone transitions, hab. session 1	0.0	0.1	0.3	-0.0	0.1	0.2	0.2	0.1	0.5
Total locomotion distance, hab. session 1	0.7	1.0	2.3	-1.2	-1.1	1.5	-0.8	0.3	0.7
Locomotion velocity, hab. session 1	1.5	2.2	4.5	-1.7	-1.7	2.1	-1.3	0.8	0.3
Time in familiar zone, hab. session 2	0.3	0.3	0.9	-0.4	-0.3	0.8	-0.1	-1.0	0.3
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.0	-0.1	-0.1	-0.2	0.6	-0.3
Total zone transitions, hab. session 2	0.6	0.7	1.2	-1.1	-1.1	1.0	-0.9	0.5	-0.2
Total locomotion distance, hab. session 2	0.9	1.2	2.3	-1.3	-1.3	1.5	-1.2	0.4	0.1
Locomotion velocity, hab. session 2	0.9	1.2	2.1	-1.3	-1.4	1.4	-1.1	0.5	0.3
Novel to familiar place preference ratio	3.7	4.0	5.5	2.2	2.3	-2.1	2.3	-1.1	1.7
Novelty place preference	4.0	4.3	6.1	2.2	2.4	-2.1	2.5	-1.2	1.8
Time in novel zone, NPP test	4.0	4.3	6.1	2.2	2.4	-2.1	2.5	-1.2	1.8
Total zone transitions, NPP test	1.0	1.5	2.1	-1.4	-1.3	1.1	-1.5	1.3	-0.8
Total locomotion distance, NPP test	1.9	2.6	4.2	-1.9	-1.8	2.1	-1.9	0.9	-0.1
Locomotion velocity, NPP test	1.9	2.7	3.8	-1.9	-1.8	1.9	-1.9	1.2	-0.4
Intraocular pressure	0.3	0.5	1.1	-0.1	-0.6	1.0	-0.2	-0.4	1.1
Delta distance traveled before/after self-admin	1.9	2.0	2.7	1.6	1.2	-1.4	1.5	-1.3	1.5
Delta ambulatory time before/after self-admin	2.1	2.6	3.9	2.0	1.5	-1.6	1.8	-1.4	1.4
Parametrial fat weight	0.9	2.2	2.8	-1.3	-1.2	1.3	-1.6	1.7	-1.7
Pavlov. Cond. lever latency	0.3	0.4	2.0	0.3	0.1	-0.0	0.3	-1.4	0.6
Pavlov. Cond. magazine entry latency	2.0	2.5	4.1	-1.7	-1.1	1.2	-1.7	1.7	-2.0
Pavlov. Cond. change in total contacts	0.9	0.9	2.8	-0.9	-0.3	0.3	-1.1	0.9	-1.7
Pavlov. Cond. index score	1.2	1.5	3.5	-1.2	-0.7	0.7	-1.1	1.9	-1.4
Pavlov. Cond. latency score	1.1	1.4	3.8	-1.0	-0.6	0.7	-1.0	1.9	-1.2
Pavlov. Cond. lever contacts	0.9	1.0	2.6	-1.0	-0.8	0.6	-1.0	1.6	-0.9
Pavlov. Cond. magazine entry number	0.8	1.0	2.5	1.0	0.5	-0.5	1.1	-0.9	1.6
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	0.2	-0.1	0.3	-0.3	0.6	-0.0
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	2.8	-1.2	-0.7	0.7	-1.1	1.7	-1.4
Pavlov. Cond. response bias	1.0	1.2	2.5	-1.3	-0.7	0.5	-1.3	1.0	-1.6
Pavlov. Cond. lever latency	1.3	1.8	2.7	1.4	1.5	-1.5	1.7	-1.0	1.0
Pavlov. Cond. magazine entry latency	0.9	1.1	2.3	-1.0	-0.6	0.6	-1.5	0.7	-1.4
Pavlov. Cond. change in total contacts	0.7	1.1	1.7	-1.0	-1.0	0.9	-1.3	1.2	-0.9
Pavlov. Cond. index score	1.4	1.9	2.9	-1.2	-1.2	1.2	-1.7	1.4	-1.4
Pavlov. Cond. latency score	1.2	1.5	2.4	-1.0	-1.0	1.0	-1.6	1.4	-1.4
Pavlov. Cond. lever contacts	1.6	2.1	3.2	-1.5	-1.7	1.6	-1.8	1.1	-1.0
Pavlov. Cond. magazine entry number	2.9	3.5	5.2	1.9	1.6	-1.7	2.3	-1.7	2.0
Pavlov. Cond. intertrial magazine entries	1.4	2.1	3.5	1.7	1.4	-1.5	1.9	-0.6	1.2
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.6	2.5	-1.1	-1.0	1.0	-1.6	1.3	-1.3
Pavlov. Cond. response bias	1.8	2.5	3.9	-1.6	-1.6	1.6	-2.0	1.2	-1.3
Time in closed arm before self-admin	1.2	1.6	2.3	1.0	1.3	-0.8	1.4	-1.3	1.5
Time in closed arm after self-admin	0.1	0.1	0.5	-0.3	-0.3	0.2	-0.2	-0.0	0.7
Time in open arm before self-admin	0.1	0.1	0.4	-0.2	-0.5	0.4	-0.2	-0.6	0.3
Time in open arm after self-admin	0.3	0.3	0.7	0.2	0.3	-0.4	0.6	-0.8	0.9
Bone: periosteal estimation	2.2	4.7	8.8	2.9	2.7	-3.0	1.8	0.6	-0.2
Bone: periosteal perimeter	2.1	3.7	7.2	2.7	2.4	-2.5	1.7	0.2	0.2
Bone: post-yield work	0.7	1.1	2.4	1.6	1.2	-1.2	0.8	0.7	-0.2
Progressive ratio test 1 active lever presses	0.3	0.3	1.1	0.8	0.4	-0.3	1.0	0.0	0.4
Progressive ratio test 1 breakpoint	0.2	0.2	0.7	0.6	0.2	-0.1	0.8	0.2	0.3
Progressive ratio test 1 inactive lever presses	0.8	1.1	2.4	1.3	1.3	-0.5	1.5	-0.6	0.8
Progressive ratio test 2 active lever presses	1.7	2.0	4.0	1.9	2.0	-0.8	1.9	-0.1	0.5
Progressive ratio test 2 breakpoint	1.8	2.1	4.1	2.0	2.0	-0.7	1.9	-0.2	0.6
Progressive ratio test 2 inactive lever presses	1.0	1.7	3.5	1.5	1.5	-0.4	1.9	-0.9	1.1
Incentive Sensitization - Responses	1.7	2.3	5.7	2.0	2.4	-1.1	1.7	-0.4	0.4
Incentive Sensitization - Breakpoint	1.6	2.1	5.2	1.9	2.3	-1.0	1.6	-0.3	0.3
Sum of active levers in priming session hrs 5-6	0.4	0.3	0.8	-0.7	-0.4	0.2	-0.6	-0.9	0.2
Progressive ratio	0.2	0.3	0.8	-0.4	-0.5	0.4	-0.8	0.9	-0.2
Food seeking constrained by brief footshock	1.5	1.8	7.7	-0.5	-0.1	0.3	-0.8	2.8	-1.5
Seeking ratio, punishment vs. effort	0.3	0.4	1.3	-0.6	-0.2	0.4	-0.3	1.1	-0.8
Retroperitoneal fat weight	0.1	0.2	1.0	0.0	-0.4	1.0	-0.5	0.1	-0.2
Reaction time number correct	1.8	3.5	5.4	2.1	2.2	-2.3	2.1	-1.1	1.0
Reaction time mean minus median	0.3	0.8	4.1	-0.2	0.3	0.1	-0.6	0.2	-2.0
Reaction time mean minus median AUC	0.2	0.5	2.2	-0.3	0.3	0.1	-0.6	-0.4	-1.5
Reaction time num false alarms	0.6	0.9	3.9	-0.1	-0.6	-0.0	-0.7	2.0	-0.8
Reaction time num false alarms AUC	0.8	1.2	4.3	-0.4	-0.7	0.1	-1.0	2.1	-1.2
Reaction time trials correct on left	1.8	3.5	5.4	2.1	2.2	-2.3	2.1	-1.1	1.0
Reaction time trials on left	1.8	3.3	5.2	2.1	2.1	-2.3	2.0	-1.0	0.9
Reaction time mean	1.5	2.5	4.5	-1.7	-1.1	1.4	-1.9	0.8	-2.1
Reaction time mean AUC	1.8	2.9	4.6	-1.9	-1.4	1.5	-2.1	0.8	-2.1
Median of all reaction times	1.5	2.1	3.2	-1.7	-1.2	1.4	-1.8	0.7	-1.6
Reaction time omissions	0.6	0.8	4.2	-0.0	0.5	-0.4	-0.4	0.5	-2.1
Reaction time false alarm rate	1.9	2.6	5.5	-1.2	-1.6	1.1	-1.8	2.4	-1.3
Reaction time premature initiation rate	2.1	2.8	6.1	-1.1	-1.1	1.3	-1.6	2.5	-2.1
Reaction time premature initiations	0.6	1.1	3.8	0.1	0.0	0.1	-0.5	2.0	-1.7
Std. dev. reaction times	1.2	2.2	7.6	-1.1	-0.4	0.9	-1.6	0.6	-2.8
Reaction time trials completed	1.8	3.3	5.2	2.1	2.1	-2.3	2.0	-1.0	0.9
Reaction time trials AUC	1.6	3.1	4.7	2.0	2.0	-2.2	1.9	-1.0	0.9
Run reversals in cocaine runway, females	0.5	0.5	1.5	-0.4	-0.6	0.4	-0.2	-0.8	1.2
Run reversals in cocaine runway, males	3.4	3.5	4.5	-1.8	-2.1	2.1	-2.0	1.8	-1.3
Latency to leave start box in cocaine runway	1.4	1.6	2.3	1.5	1.5	-1.4	1.4	-0.9	0.4
Latency to leave start box in cocaine runway, F	2.3	2.6	4.0	1.8	2.0	-1.8	1.8	-1.1	0.7
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.3	0.2	-0.3	0.3	-0.4	0.2
Std. dev. time between licks in bursts	1.5	2.1	4.0	-1.7	-2.0	1.5	-1.7	-0.2	-0.6
Total sessions with >9 infusions	0.2	0.2	0.5	-0.1	-0.5	0.7	-0.0	-0.2	0.7
Short access day 1 total inactive lever presses	4.4	5.8	8.4	2.2	1.7	-1.7	2.8	-2.8	2.9
Short access day 10 total inactive lever presses	0.0	0.1	0.3	0.2	0.5	-0.1	0.1	-0.3	0.0
Short access day 1 total infusions	0.3	0.4	1.1	-0.1	-0.6	0.8	0.3	-0.5	1.0
Short access day 10 total infusions	0.4	0.6	2.0	-0.7	-0.9	1.4	-0.4	0.2	-0.1
Short access total infusions	0.3	0.3	0.7	0.7	0.3	0.1	0.9	-0.3	0.8
Short access day 1 locomotion	1.1	1.4	4.4	0.6	0.2	-0.1	1.0	-1.6	2.1
Short access day 10 total locomotion	0.1	0.1	0.3	-0.4	-0.5	0.1	-0.0	-0.2	0.5
Short access total locomotion	0.5	0.6	1.8	-0.1	-0.2	0.3	0.3	-1.3	1.3
One hour access (0.3 mA shock)	2.8	3.2	6.4	2.4	2.5	-1.5	2.2	0.2	-0.1
Compulsive drug intake	0.7	0.8	1.8	1.2	1.4	-0.8	0.9	-0.4	-0.4
One hour access (shock baseline)	0.2	0.4	0.8	0.7	0.6	-0.4	0.5	0.9	-0.5
Social response proportion	3.6	4.1	5.8	1.9	1.9	-2.4	2.3	-2.0	1.5
Social responses	0.8	1.0	1.7	1.1	0.7	-1.3	1.2	-0.9	0.7
Social time	0.4	0.5	0.8	-0.8	-0.9	0.2	-0.8	0.8	-0.7
Soleus weight	0.9	2.6	5.2	2.1	1.8	-2.3	1.5	-0.8	0.4
Bone: stiffness	1.0	1.6	3.0	1.6	1.2	-1.2	0.8	1.7	-0.5
Tibialis anterior weight	0.7	2.2	3.6	1.9	1.6	-1.9	1.6	1.0	0.4
Time to tail flick, vehicle, before self-admin	1.4	1.5	4.9	0.0	-0.3	0.3	0.6	-1.9	2.2
Time to tail flick, vehicle, after self-admin	0.4	0.5	1.9	0.5	0.5	-0.5	-0.0	1.4	0.3
Time to tail flick, test, before self-admin	0.6	0.6	1.2	0.9	0.8	-0.8	1.1	0.2	0.4
Time to tail flick, test, after self-admin	1.2	1.2	3.8	0.4	0.5	-0.3	0.7	-1.6	1.9
Delta time to tail flick, vehicle, before/after SA	1.7	1.6	6.5	0.9	0.9	-0.8	0.0	2.6	-0.9
Delta time to tail flick, test, before/after SA	0.5	0.5	1.6	-0.2	-0.0	0.5	-0.1	-1.0	1.3
Tibia length	0.2	0.6	1.0	-0.7	-0.6	0.6	-0.8	1.0	-1.0
Ambulatory time before self-admin	0.4	0.6	1.3	0.3	1.1	-1.1	0.7	-0.7	0.3
Ambulatory time after self-admin	5.5	6.5	8.0	2.3	2.7	-2.8	2.8	-2.4	2.2
Bone: tissue strength	0.2	0.2	1.0	-0.0	0.1	-0.3	-0.5	0.1	-1.0
Total heroin consumption	0.1	0.1	0.8	0.0	-0.1	0.1	-0.3	0.9	-0.1
Bone: trabecular number	2.5	4.1	5.8	2.4	2.3	-2.0	2.3	-1.4	1.4
Bone: trabecular spacing	2.0	2.6	3.6	-1.6	-1.4	1.9	-1.8	1.3	-1.6
Bone: trabecular thickness	1.6	2.0	3.4	1.8	1.8	-1.5	1.6	-0.5	0.5
Bone: trabecular tissue density	0.7	1.0	1.7	1.3	1.2	-1.3	1.1	-0.4	0.4
Water consumed over 24 hours	0.7	0.9	1.6	0.9	1.2	-0.5	1.1	-0.4	1.3
Number of responses in last shaping day	0.6	0.6	2.4	0.2	-0.2	0.7	0.4	-1.5	0.8