Hub : Genes

Rbfox3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Rbfox3 0.06 0.04 1.0e-03 0.04 0.03 0.03 0.03 5.1e-05 3.9e-04 2.5e-04 1.7e-04
2 NAcc mRNA stability Rbfox3 0.03 0.02 1.0e-04 0.03 0.02 0.02 0.02 2.0e-05 8.0e-04 5.4e-04 1.7e-04
3 Brain isoform ratio XM_063268785.1 0.2 0.08 0.0e+00 0.19 0.23 0.23 0.22 2.5e-17 3.8e-21 4.0e-21 8.5e-21
4 PL alternative TSS NM_001413230.1 0.08 0.05 4.0e-06 0.03 0.04 0.04 0.04 2.2e-04 4.7e-05 3.0e-05 4.5e-05
5 IC intron excision ratio chr10_104235671_104242895 0.08 0.07 9.6e-03 0.03 0.04 0 0.04 2.4e-02 8.7e-03 2.3e-01 1.3e-02
6 OFC alternative TSS XM_063268786.1 0.19 0.1 1.8e-03 0.03 0.05 0 0.02 6.4e-02 2.1e-02 2.6e-01 1.2e-01
7 Brain gene expression Rbfox3 0.1 0.04 3.9e-09 0.1 0.08 0.08 0.08 3.5e-09 3.6e-08 9.3e-08 5.9e-08
8 Brain alternative TSS NM_001413230.1 0.25 0.11 0.0e+00 0.3 0.29 0.3 0.29 8.6e-28 2.4e-27 8.4e-28 1.6e-27
9 pVTA intron excision ratio chr10_104243149_104301142 0.12 0.06 5.8e-06 0.09 0.07 0.08 0.08 1.3e-07 2.4e-06 9.2e-07 8.5e-07
10 IC mRNA stability Rbfox3 0.16 0.1 8.9e-04 0.05 0.08 0.09 0.07 3.2e-03 2.1e-04 2.1e-04 9.1e-04
11 IL alternative TSS XM_063268786.1 0.29 0.12 3.7e-05 0.08 0.13 0.07 0.12 6.0e-03 5.2e-04 8.9e-03 7.6e-04
12 Brain mRNA stability Rbfox3 0.03 0.02 1.5e-03 0.03 0.03 0.02 0.03 5.7e-04 1.1e-03 2.8e-03 1.6e-03
13 OFC alternative polyA NM_001413230.1 0.35 0.17 5.2e-03 0.03 0.07 0.06 0.05 5.3e-02 1.1e-02 1.7e-02 2.5e-02
14 OFC alternative polyA NM_001413230.1 0.36 0.17 5.7e-03 0.04 0.07 0.06 0.05 4.9e-02 8.8e-03 1.8e-02 2.0e-02
15 Adipose alternative polyA XM_063268786.1 0.05 0.03 7.3e-04 0.02 0.01 0.01 0.02 5.5e-03 1.6e-02 2.5e-02 2.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.42.33.9-1.8-1.8-1.81.5-1.5-1.3-1.91.32.0-1.8-0.61.21.51.5-0.5
Area under the delay curve1.01.24.80.20.10.6-0.62.21.0-0.1-1.50.12.01.7-1.40.20.30.1
BMI with tail1.03.410.43.23.11.5-2.2-0.50.02.80.4-2.60.5-1.20.8-1.7-1.8-0.1
BMI without tail0.31.02.41.41.30.6-1.0-1.4-0.21.00.5-0.8-1.5-0.50.90.10.1-1.5
Body weight1.35.715.03.93.83.1-3.60.72.13.2-1.7-2.80.51.3-1.1-1.3-1.3-1.1
Weight adjusted by age0.60.92.7-0.3-0.30.1-0.6-0.20.6-0.8-0.91.1-1.51.3-0.11.31.3-1.6
Bone surface1.32.35.1-2.1-2.1-0.91.40.40.3-2.2-0.52.3-0.91.7-0.71.91.9-0.7
Bone volume1.42.55.3-2.2-2.2-1.41.7-0.6-0.5-2.20.52.3-1.60.60.21.91.9-0.8
Breakpoint value in progressive ratio session1.01.23.0-1.0-1.0-0.90.4-0.8-0.7-1.70.61.4-1.5-0.11.11.31.3-1.1
Number of licking bursts0.10.10.30.50.50.4-0.30.20.30.3-0.5-0.30.20.3-0.2-0.1-0.1-0.3
Context. condit. distance diff. score0.50.53.3-0.6-0.6-0.50.4-0.1-0.6-0.30.20.50.30.1-0.41.21.2-1.8
Locomotion velocity, session 12.52.76.61.61.61.4-0.82.21.61.4-1.3-1.32.61.0-1.5-1.8-1.72.1
Locomotion distance, session 10.60.82.8-0.2-0.2-1.00.7-0.8-1.3-0.21.30.30.0-1.71.5-0.3-0.30.7
Locomotion velocity, session 20.60.74.1-0.2-0.2-0.60.8-0.0-0.5-0.10.80.20.8-1.00.7-0.9-0.92.0
Locomotion distance, session 21.52.15.8-0.5-0.5-1.60.9-2.2-1.9-0.62.10.8-1.4-2.32.40.20.10.2
Locomotion velocity, session 30.50.62.30.40.40.50.01.20.70.6-0.6-0.51.50.5-0.8-0.8-0.81.1
Locomotion distance, session 31.01.12.71.01.00.2-0.10.3-0.31.00.5-1.11.2-1.20.7-1.6-1.61.6
Stereotopy head waving bouts, day 30.40.51.60.40.40.6-0.21.00.80.5-0.5-0.41.10.8-1.3-0.4-0.40.5
Stereotopy head waving duration, day 30.30.31.6-0.1-0.10.30.31.00.50.0-0.30.11.00.9-1.30.10.20.1
Locomotion velocity, session 70.30.30.6-0.6-0.6-0.50.70.7-0.1-0.8-0.10.80.60.40.00.50.6-0.1
Locomotion distance, session 72.43.15.8-1.7-1.7-2.32.4-1.1-2.3-1.92.12.0-0.7-1.52.11.31.3-0.6
Stereotopy head waving bouts, day 70.80.93.30.40.41.1-0.71.31.10.5-1.0-0.71.01.3-1.80.00.1-0.9
Stereotopy head waving duration, day 71.21.55.60.30.31.3-0.71.71.50.6-1.5-0.81.21.9-2.40.00.1-0.7
Locomotion velocity, session 80.70.91.8-0.8-0.8-0.30.61.2-0.0-0.7-0.50.81.41.1-1.11.21.2-1.3
Locomotion distance, session 82.13.05.7-1.3-1.3-2.11.5-2.1-2.4-1.12.21.4-1.2-1.71.81.71.6-1.9
Degree of sensitization distance5.45.59.8-2.8-2.8-2.52.2-1.8-1.8-2.91.43.1-2.5-0.31.52.92.9-2.1
Degree of sensitization stereotypy0.30.31.20.10.10.6-0.50.60.40.2-0.4-0.40.30.7-0.90.30.3-1.1
Conditioned locomotion1.01.24.7-0.8-0.8-0.7-0.2-1.3-0.8-0.70.40.9-1.7-0.20.51.51.4-2.2
Cocaine response after cond. corrected0.10.10.50.40.40.3-0.20.40.20.5-0.1-0.40.70.1-0.2-0.4-0.40.4
Cocaine response after cond. not corrected0.20.21.00.10.10.10.30.80.30.2-0.3-0.01.00.4-0.4-0.2-0.20.7
Cocaine response before conditioning0.50.61.2-0.9-0.9-0.61.10.80.1-1.0-0.31.10.60.9-0.40.80.80.0
Saline control response0.40.61.9-0.0-0.00.5-0.50.40.8-0.2-0.60.1-0.31.4-1.20.80.9-1.3
Bone: connectivity density1.62.55.3-2.1-2.1-1.81.8-0.8-1.1-2.20.82.3-1.3-0.20.91.81.8-0.5
Bone: cortical apparent density0.91.24.70.20.2-0.80.7-1.0-1.30.41.5-0.40.2-2.21.5-1.1-1.11.5
Bone: cortical area4.06.216.13.43.43.1-4.00.92.33.3-2.2-3.20.91.1-1.5-2.0-2.0-0.2
Bone: cortical porosity0.80.82.40.50.61.2-0.81.11.50.3-1.3-0.30.31.5-1.0-0.4-0.40.6
Bone: cortical porosity1.01.13.40.50.51.3-1.01.31.70.3-1.6-0.40.51.8-1.4-0.2-0.10.1
Bone: cortical thickness7.412.326.95.25.23.8-5.2-0.02.05.1-1.6-4.90.8-0.6-0.4-3.8-3.91.1
Bone: cortical thickness3.54.19.53.03.02.0-3.10.00.92.9-0.9-2.80.8-0.70.1-2.2-2.30.6
Bone: cortical tissue density0.91.34.70.10.1-0.90.9-1.1-1.30.31.6-0.20.2-2.21.6-1.0-1.11.6
Condit. Reinf. active minus inactive responses0.70.82.0-1.0-1.0-0.5-0.1-1.0-0.4-0.90.10.8-1.4-0.10.41.11.1-1.4
Condit. Reinf. active-inactive response ratio1.61.72.8-1.7-1.7-1.20.8-1.0-0.8-1.70.31.6-1.5-0.10.51.71.6-1.6
Condit. Reinf. active responses0.70.83.4-0.8-0.8-0.4-0.4-1.4-0.4-0.70.10.7-1.8-0.20.51.01.0-1.5
Condit. Reinf. inactive responses0.10.20.9-0.1-0.1-0.1-0.4-0.8-0.20.00.30.0-1.0-0.30.40.10.1-0.3
Incentive salience index mean0.40.51.6-1.0-1.0-0.4-0.2-0.8-0.2-0.8-0.10.6-1.10.00.20.90.9-1.3
Condit. Reinf. lever presses0.20.30.5-0.7-0.7-0.60.4-0.7-0.6-0.50.60.5-0.5-0.50.40.50.4-0.7
Condit. Reinf. active minus inactive responses0.50.61.7-0.5-0.50.1-0.50.70.5-0.5-0.90.50.41.2-0.91.01.0-1.3
Condit. Reinf. active-inactive response ratio0.40.51.60.10.10.7-1.10.50.9-0.0-1.00.1-0.11.3-0.70.40.5-0.8
Condit. Reinf. active responses0.71.02.2-1.2-1.2-1.00.7-0.3-0.8-1.20.41.2-0.30.10.11.51.5-1.5
Condit. Reinf. inactive responses1.51.93.5-1.7-1.7-1.81.9-1.0-1.7-1.51.41.4-0.7-1.00.81.31.2-0.8
Condit. Reinf. lever presses2.53.55.0-2.1-2.1-2.11.9-1.6-1.9-1.91.72.0-1.7-0.81.02.22.2-2.1
Condit. Reinf. lever reinforcers received1.11.53.0-1.4-1.4-1.40.9-0.8-1.3-1.30.91.4-0.6-0.40.51.71.6-1.7
Conditioned reinforcement - actives0.40.72.6-0.00.0-0.60.6-1.3-0.9-0.11.10.2-1.4-1.31.6-0.2-0.30.5
Conditioned reinforcement - inactives0.10.10.80.30.30.50.1-0.30.20.2-0.3-0.5-0.90.00.1-0.1-0.1-0.5
Conditioned locomotion1.01.34.3-0.5-0.6-0.90.8-1.7-1.1-0.91.10.8-2.1-1.12.00.50.5-0.2
Patch foraging indifference point 0 sec1.62.96.1-1.7-1.7-1.81.5-2.4-1.8-1.62.01.4-2.5-1.51.61.31.3-1.1
Patch foraging indifference point AUC0.60.92.4-1.1-1.1-0.90.7-0.4-0.5-1.5-0.01.5-0.90.20.61.31.3-0.7
Delay disc. indifference point, 0s delay1.21.33.01.01.11.2-1.11.71.30.7-1.5-0.71.61.6-1.5-0.2-0.2-0.2
Delay disc. indifference point, 16s delay0.40.50.8-0.8-0.9-0.90.60.0-0.8-0.90.40.90.2-0.20.40.80.8-0.7
Delay disc. indifference point, 2s delay0.70.82.70.50.50.7-0.81.71.1-0.2-1.60.10.81.6-0.70.10.2-0.1
Delay disc. indifference point, 24s delay0.30.32.10.00.0-0.10.30.90.1-0.2-0.10.11.10.1-0.1-0.5-0.51.5
Delay disc. indifference point, 4s delay1.41.54.70.60.51.0-1.22.21.30.2-1.8-0.21.62.0-1.50.20.3-0.3
Delay disc. indifference point, 8s delay2.83.310.70.80.81.5-1.13.32.10.7-2.5-0.73.02.6-2.6-0.4-0.30.5
Indifference point function ln k0.81.43.81.01.00.10.2-0.9-0.81.51.4-1.50.3-2.00.9-1.5-1.61.2
Indifference point function log k0.81.43.81.01.00.10.2-0.9-0.81.51.4-1.50.3-2.00.9-1.5-1.61.2
Patch foraging total patch changes 0 sec1.93.67.2-1.8-1.8-2.01.7-2.7-2.1-1.62.21.5-2.7-1.81.91.41.4-1.3
Patch foraging total patch changes 12 sec1.92.46.4-1.4-1.4-1.60.8-2.1-1.4-1.81.51.7-2.5-1.11.81.21.2-0.6
Patch foraging total patch changes 18 sec3.85.89.4-2.9-3.0-2.72.1-2.0-2.3-3.11.73.0-2.5-1.01.72.72.7-2.0
Patch foraging total patch changes 24 sec0.71.23.3-1.3-1.3-0.70.1-0.5-0.3-1.3-0.01.2-1.00.6-0.61.71.7-1.8
Patch foraging total patch changes 6 sec1.11.77.0-0.9-0.9-1.10.4-2.1-1.0-1.31.21.1-2.6-1.01.60.80.7-0.2
Patch foraging time to switch 0 sec0.20.31.30.10.10.3-0.51.10.50.0-0.3-0.31.20.6-0.8-0.4-0.40.7
Patch foraging water rate 0 sec0.71.55.5-0.5-0.5-0.80.8-1.7-1.1-0.60.60.8-2.1-0.51.01.51.5-2.4
Patch foraging water rate 12 sec0.71.55.80.40.4-0.50.3-1.9-1.70.82.1-0.9-0.8-2.41.6-0.4-0.5-0.7
Patch foraging water rate 18 sec0.91.43.2-0.6-0.7-0.91.1-1.8-1.3-0.51.70.5-1.8-1.01.11.11.0-1.5
Patch foraging water rate 24 sec3.65.110.2-1.9-1.9-2.01.7-2.9-2.5-1.52.51.6-2.9-1.71.82.42.4-3.2
Patch foraging water rate 6 sec0.60.91.91.41.40.4-0.8-0.7-0.61.40.6-1.40.1-1.30.7-0.9-0.90.1
Seeking ratio, delayed vs. immediate footshock0.30.41.10.80.60.7-1.10.40.80.1-1.0-0.2-0.50.8-0.2-0.2-0.2-0.2
Distance traveled before self-admin0.40.51.10.40.40.9-0.50.70.80.6-1.0-0.60.11.0-0.90.10.2-1.0
Distance traveled after self-admin2.32.94.3-2.0-1.9-1.81.7-1.9-1.6-1.61.31.6-2.1-0.81.21.91.9-1.7
Extensor digitorum longus weight0.62.56.3-0.5-0.4-1.50.6-2.5-2.3-0.52.30.5-1.7-2.52.50.60.5-1.0
Bone: elastic displacement1.01.12.51.21.20.4-1.1-1.6-0.41.20.6-1.1-1.3-1.41.2-0.9-1.00.1
Bone: elastic work2.33.08.12.52.52.1-2.8-0.61.32.5-1.0-2.4-0.7-0.0-0.2-1.6-1.70.2
Bone: endosteal estimation1.84.08.4-2.8-2.9-1.71.80.3-0.6-2.90.02.9-0.61.3-0.42.72.8-1.7
Bone: endosteal perimeter1.53.210.2-1.7-1.70.20.31.91.5-1.7-2.21.70.53.2-2.31.92.0-1.4
Epididymis fat weight0.10.52.01.01.10.4-0.9-0.6-0.20.5-0.1-0.4-0.8-0.10.50.50.4-1.4
Delta time in closed arm before/after self-admin0.40.41.2-1.0-0.9-0.50.10.1-0.1-0.7-0.21.10.30.5-0.20.90.9-0.5
Delta time in open arm before/after self-admin0.50.52.4-0.5-0.5-0.50.8-1.0-0.7-0.40.70.2-1.5-0.70.90.30.3-0.4
Diff in mean of infusions in LGA sessions0.70.82.7-0.9-0.9-0.50.20.00.1-1.7-0.41.3-0.80.90.11.31.3-1.1
Delay discount exponential model param1.21.45.6-0.3-0.2-0.70.6-2.4-1.10.01.6-0.0-2.2-1.81.5-0.1-0.1-0.3
Extinction: sum of active levers before priming0.30.41.3-0.3-0.2-0.60.6-0.8-0.8-0.21.0-0.1-0.2-1.10.8-0.2-0.30.6
Active lever presses in extinction session 60.20.21.00.00.1-0.30.1-0.2-0.1-0.9-0.20.6-0.90.11.00.40.4-0.2
Bone: final force2.13.39.52.42.42.3-3.10.71.82.3-1.7-2.20.61.2-1.5-0.9-0.9-0.9
Bone: final moment2.03.29.52.32.32.4-3.10.51.82.3-1.6-2.10.31.2-1.4-0.9-0.9-1.0
Food consumed during 24 hour testing period0.91.23.8-1.4-1.4-0.60.9-0.0-0.2-0.9-0.41.1-0.40.8-0.81.61.6-1.9
Glucose2.33.614.31.71.71.1-0.51.41.01.8-0.6-1.82.4-0.4-0.6-2.8-2.83.8
Heart weight2.43.77.92.82.82.1-2.60.31.12.6-0.5-2.81.1-0.3-0.3-2.2-2.20.9
Delay discount hyperbolic model param1.31.55.7-0.4-0.4-0.80.8-2.4-1.2-0.11.70.1-2.1-1.81.50.0-0.1-0.2
Intermittent access intake day 1-15 change0.10.31.20.20.30.6-0.20.50.50.5-0.5-0.50.80.4-1.1-0.3-0.3-0.0
Intermittent access intake escalation0.10.30.80.50.50.6-0.30.40.50.7-0.3-0.70.80.2-0.9-0.5-0.50.1
Intermittent access intake escalation 20.30.30.70.50.60.7-0.60.70.80.3-0.6-0.40.50.8-0.7-0.2-0.20.1
Intermitt. access day 1 inactive lever presses0.31.04.9-1.1-1.1-0.30.4-1.2-0.5-0.60.50.2-1.5-0.2-0.41.31.2-2.2
Intermitt. access day 15 inactive lever presses0.51.02.3-1.1-1.1-0.80.2-1.0-0.8-1.00.51.0-1.3-0.30.61.31.3-1.5
Intermitt. access escalation Index0.30.41.3-1.1-1.0-0.3-0.1-0.3-0.1-0.6-0.20.4-0.50.2-0.60.80.8-1.1
Intermittent access day 1 total infusions0.30.51.70.20.2-0.30.2-1.3-0.70.51.0-0.2-1.0-1.31.1-0.4-0.50.4
Intermittent access day 15 total infusions0.10.20.80.10.2-0.0-0.1-0.9-0.20.40.4-0.2-0.6-0.60.3-0.2-0.20.0
Intermittent access terminal intake (last 3 days)0.00.10.30.00.10.1-0.2-0.50.00.10.1-0.1-0.6-0.20.1-0.0-0.1-0.1
Intermittent access total infusions0.20.20.80.20.2-0.1-0.2-0.9-0.30.40.5-0.2-0.7-0.70.5-0.2-0.30.1
Intermittent access day 1 locomotion0.50.62.0-0.2-0.3-0.70.7-1.3-0.7-0.50.90.8-1.3-0.81.40.40.4-0.0
Intermittent access day 15 total locomotion0.10.20.40.70.60.4-0.0-0.50.10.5-0.0-0.4-0.5-0.20.4-0.3-0.3-0.0
Intermittent access total locomotion0.20.20.90.30.3-0.10.2-0.9-0.40.10.50.1-0.9-0.60.9-0.0-0.0-0.0
Intermittent access standard deviation1.73.69.32.02.02.0-1.62.21.72.1-1.7-2.13.01.2-2.1-1.5-1.40.5
Left kidney weight1.15.39.43.13.02.7-2.12.32.42.6-2.0-2.52.51.8-2.2-1.8-1.71.0
Right kidney weight0.83.67.72.72.82.2-2.11.41.72.4-1.5-2.11.80.9-1.0-1.8-1.81.2
Cocaine induced anxiety1.31.85.81.31.31.8-2.41.11.71.0-1.6-1.30.51.4-1.2-0.8-0.7-0.1
Post-drug Anxiety0.80.92.51.11.11.2-1.60.50.90.9-0.7-1.30.40.3-0.5-1.0-1.00.4
Baseline Anxiety0.80.93.0-0.7-0.7-1.21.7-0.8-1.2-0.81.20.9-0.5-1.11.10.30.20.6
Tail length0.52.07.3-0.1-0.11.0-1.00.31.7-0.4-1.80.7-1.42.7-1.31.61.7-2.1
Length with tail1.45.914.22.42.43.1-3.02.43.51.8-3.4-1.31.13.8-2.8-0.4-0.3-0.5
Length without tail2.47.713.53.63.73.3-3.52.63.03.2-2.8-2.72.32.2-2.2-2.1-2.11.0
Times rat made contact with spout0.50.62.3-1.1-1.1-0.50.4-0.9-0.1-0.90.10.9-1.50.20.30.90.9-0.6
Lifetime Intake0.10.20.60.20.2-0.1-0.1-0.7-0.40.40.6-0.2-0.2-0.80.5-0.3-0.30.2
Liver weight, left0.60.91.60.80.91.1-0.61.31.20.9-0.7-0.81.00.9-1.1-1.0-1.01.1
Liver weight, right0.61.13.30.30.31.2-1.50.61.40.3-1.4-0.1-0.61.8-1.40.60.6-1.4
Locomotor activity0.10.10.50.30.3-0.30.70.1-0.3-0.10.50.20.2-0.20.2-0.1-0.10.5
Locomotor testing distance0.30.51.8-0.6-0.6-1.01.4-0.1-0.8-0.90.71.1-0.2-0.20.40.80.8-0.2
Locomotor testing rearing1.02.13.0-1.6-1.6-1.61.5-1.1-1.5-1.71.41.7-1.2-0.60.91.71.7-1.5
Locomotion in novel chamber1.92.45.3-2.1-1.9-1.51.7-0.6-0.7-2.10.42.3-1.50.50.52.12.1-1.2
Locomotion in novel chamber post-restriction0.81.32.9-1.7-1.4-0.71.3-0.50.1-1.1-0.01.4-1.10.9-0.71.51.5-1.2
Fecal boli incidents, locomotor time 10.40.61.2-0.7-0.7-1.10.3-0.9-0.9-0.71.00.8-0.6-0.91.10.30.20.3
Change in fecal boli incidents, locomotor task0.40.42.50.10.20.00.40.1-0.10.40.2-0.40.5-0.60.1-1.0-1.01.6
Time >=10cm from walls, locomotor time 10.91.02.0-1.4-1.3-0.91.40.1-0.7-1.00.20.90.50.2-0.51.31.4-1.4
Bouts of movement, locomotor time 10.50.62.00.40.4-0.1-0.0-0.3-0.50.60.7-0.50.9-1.30.7-1.1-1.21.4
Total resting periods, locomotor time 10.70.73.00.20.2-0.30.4-0.5-0.60.50.9-0.40.8-1.40.8-1.2-1.21.7
Rest time, locomotor task time 11.11.44.01.31.30.9-0.70.10.51.50.1-1.40.4-0.5-0.0-1.8-1.82.0
Distance moved, locomotor task time 10.40.62.5-0.8-0.9-0.30.40.10.0-0.9-0.40.8-0.60.8-0.21.21.2-1.6
Vertical activity count, locomotor time 10.51.13.1-0.9-1.1-0.90.5-0.5-0.6-1.50.21.3-0.80.20.61.51.5-1.8
Time >=10cm from walls, locomotor time 20.00.10.20.30.30.2-0.2-0.20.10.10.1-0.2-0.5-0.10.3-0.2-0.20.1
Bouts of movement, locomotor time 20.10.21.2-0.2-0.2-0.40.50.2-0.30.00.20.11.1-0.4-0.1-0.2-0.20.6
Total resting periods, locomotor time 20.10.10.8-0.4-0.5-0.50.50.1-0.3-0.20.20.30.9-0.3-0.10.10.10.3
Rest time, locomotor task time 20.00.10.2-0.2-0.2-0.1-0.20.20.2-0.1-0.00.30.40.3-0.30.10.10.5
Distance moved, locomotor task time 20.50.61.51.21.11.0-0.90.30.70.7-0.7-0.9-0.40.30.1-0.6-0.6-0.1
Vertical activity count, locomotor time 20.20.20.90.90.80.4-0.5-0.00.00.5-0.2-0.6-0.1-0.20.4-0.3-0.3-0.4
Light reinforcement 11.02.45.6-1.3-1.3-1.40.5-2.4-1.6-1.11.81.2-2.3-1.41.71.31.3-1.5
Light reinforcement 20.10.21.10.30.20.4-1.0-0.30.30.4-0.3-0.2-0.40.3-0.20.30.3-0.9
Bone: marrow area1.83.98.3-2.8-2.8-1.71.70.3-0.6-2.90.02.8-0.51.3-0.42.72.8-1.7
Bone: maximum diameter2.14.09.01.31.32.3-2.32.52.71.2-2.9-1.21.83.0-2.9-0.3-0.2-0.8
Bone: maximum force1.32.37.32.02.02.0-2.70.31.51.9-1.4-1.80.21.1-1.2-0.6-0.6-1.0
Bone: maximum moment1.32.27.11.91.92.0-2.70.21.51.9-1.3-1.7-0.11.0-1.1-0.6-0.6-1.0
Mean time between licks in bursts0.10.20.70.50.50.20.30.60.10.4-0.3-0.50.9-0.1-0.2-0.6-0.60.7
Mean num. licks in bursts0.60.92.2-1.3-1.3-0.90.6-1.3-0.8-0.90.90.9-1.5-0.60.80.70.7-0.3
Cd content in liver1.61.74.9-0.6-0.6-1.40.8-1.9-2.0-0.62.00.5-1.3-2.21.90.40.3-0.7
Co content in liver0.20.20.6-0.4-0.4-0.3-0.0-0.8-0.3-0.30.40.2-0.7-0.70.5-0.1-0.10.2
Cu content in liver0.10.10.40.10.10.5-0.40.10.6-0.0-0.7-0.1-0.40.6-0.2-0.0-0.0-0.0
Fe content in liver1.31.63.1-1.7-1.7-1.21.6-0.1-0.7-1.60.61.7-0.50.3-0.11.61.7-1.1
K content in liver0.70.61.5-1.1-1.1-0.60.3-0.8-0.4-0.80.10.8-0.90.00.11.11.1-1.2
Mg content in liver2.42.43.4-1.8-1.8-1.71.5-1.7-1.6-1.71.41.7-1.6-1.01.31.51.5-1.1
Mn content in liver0.20.30.60.30.30.5-0.50.70.60.3-0.8-0.20.70.7-0.6-0.1-0.0-0.3
Na content in liver0.30.30.7-0.8-0.8-0.40.60.1-0.1-0.7-0.10.6-0.10.4-0.30.70.7-0.5
Rb content in liver1.01.13.1-0.8-0.8-0.90.3-1.4-1.1-0.80.80.7-1.6-0.60.91.31.3-1.8
Se content in liver1.31.53.2-1.3-1.3-1.21.1-0.6-0.9-1.60.51.8-1.30.10.61.71.7-1.4
Sr content in liver0.50.41.60.60.60.3-0.2-0.30.20.50.2-0.5-0.2-0.60.4-1.1-1.11.3
Zn content in liver0.10.10.30.30.30.4-0.5-0.50.30.4-0.2-0.4-0.60.0-0.1-0.2-0.2-0.0
Bone: minimum diameter0.71.24.0-0.1-0.11.0-1.00.61.4-0.1-1.50.1-0.52.0-1.60.91.0-1.7
Time in familiar zone, hab. session 10.30.30.8-0.5-0.5-0.50.6-0.9-0.7-0.10.9-0.0-0.5-0.90.3-0.0-0.0-0.0
Time in novel zone, hab. session 10.50.51.70.50.50.7-0.61.30.80.2-1.1-0.21.01.2-0.90.10.10.0
Total zone transitions, hab. session 10.71.02.2-0.8-0.8-1.21.0-1.2-1.4-0.71.50.9-0.8-1.21.20.60.6-0.3
Total locomotion distance, hab. session 10.70.92.0-0.5-0.5-1.00.5-1.4-1.3-0.51.30.7-1.1-1.11.30.80.8-0.8
Locomotion velocity, hab. session 10.81.22.8-0.5-0.4-1.00.4-1.7-1.4-0.41.40.7-1.4-1.41.60.70.7-0.9
Time in familiar zone, hab. session 20.10.10.5-0.1-0.1-0.40.5-0.4-0.7-0.10.70.0-0.0-0.70.30.10.1-0.1
Time in novel zone, hab. session 20.10.10.3-0.1-0.10.3-0.10.60.4-0.0-0.4-0.10.40.5-0.5-0.1-0.10.1
Total zone transitions, hab. session 23.13.97.0-1.5-1.6-2.41.7-2.6-2.6-1.62.71.8-2.0-2.32.51.31.3-0.8
Total locomotion distance, hab. session 22.63.38.5-1.0-1.0-1.90.9-2.9-2.3-1.02.41.2-2.3-2.42.71.00.9-0.9
Locomotion velocity, hab. session 22.23.07.9-0.9-1.0-1.80.7-2.8-2.1-0.92.21.2-2.4-2.22.61.00.9-1.0
Novel to familiar place preference ratio2.32.58.0-1.5-1.5-1.50.6-2.4-1.4-1.41.41.4-2.8-1.21.71.21.2-1.1
Novelty place preference2.02.16.7-1.5-1.5-1.30.6-2.2-1.2-1.41.21.4-2.6-1.01.51.21.2-1.0
Time in novel zone, NPP test2.22.47.1-1.5-1.5-1.50.7-2.3-1.4-1.41.41.4-2.7-1.21.61.21.2-1.0
Total zone transitions, NPP test1.52.24.1-1.0-1.0-1.81.2-1.8-2.0-1.12.01.3-1.2-1.82.01.00.9-0.7
Total locomotion distance, NPP test3.14.210.9-0.9-0.9-2.11.2-3.3-2.8-0.83.01.0-2.3-3.03.00.80.7-0.9
Locomotion velocity, NPP test2.53.69.4-0.9-0.9-1.91.1-3.1-2.5-0.82.71.1-2.2-2.72.80.90.8-0.9
Intraocular pressure2.13.05.3-2.0-2.0-1.91.0-1.8-1.6-2.01.32.1-2.3-0.81.41.91.9-1.3
Delta distance traveled before/after self-admin2.02.13.5-1.3-1.3-1.81.5-1.9-1.8-1.21.71.4-1.5-1.61.61.01.0-0.4
Delta ambulatory time before/after self-admin2.32.94.6-1.8-1.7-2.11.9-1.9-2.1-1.71.91.9-1.5-1.71.91.11.1-0.1
Parametrial fat weight0.20.51.5-0.3-0.3-0.40.8-1.1-0.5-0.70.60.6-1.2-0.40.70.70.7-1.0
Pavlov. Cond. lever latency1.92.54.7-1.9-1.9-1.92.2-0.4-1.8-1.71.31.8-0.3-0.60.61.91.9-1.4
Pavlov. Cond. magazine entry latency1.31.74.70.70.71.7-1.51.52.00.6-2.0-0.70.62.2-1.8-0.2-0.1-0.5
Pavlov. Cond. change in total contacts0.50.50.90.60.60.3-0.8-0.9-0.00.60.4-0.7-0.6-0.90.9-0.9-0.90.9
Pavlov. Cond. index score1.31.74.11.21.21.9-2.00.71.91.2-1.7-1.20.11.5-1.2-0.7-0.7-0.1
Pavlov. Cond. latency score1.92.54.91.61.62.2-2.21.02.21.6-1.9-1.50.51.6-1.4-1.2-1.20.4
Pavlov. Cond. lever contacts0.91.02.11.21.21.2-1.5-0.31.01.2-0.4-1.3-0.4-0.1-0.0-1.3-1.40.9
Pavlov. Cond. magazine entry number1.51.94.5-1.1-1.1-1.91.7-1.4-2.1-1.01.91.1-0.7-1.91.70.70.6-0.0
Pavlov. Cond. intertrial magazine entries1.82.23.3-1.7-1.7-1.81.2-1.8-1.7-1.51.51.4-1.8-1.41.51.21.1-0.7
Pavlov. Cond. lever-magazine prob. diff.0.91.23.31.01.01.6-1.80.41.60.9-1.4-1.0-0.21.2-0.9-0.6-0.6-0.2
Pavlov. Cond. response bias1.21.43.11.11.11.7-1.70.81.81.0-1.5-1.20.31.3-1.1-0.9-0.90.4
Pavlov. Cond. lever latency3.24.37.02.52.62.1-1.61.71.72.3-1.5-2.32.20.5-0.9-2.6-2.62.5
Pavlov. Cond. magazine entry latency1.41.74.1-1.1-1.1-1.61.5-1.4-2.0-0.82.00.7-0.8-1.81.20.70.7-0.6
Pavlov. Cond. change in total contacts2.23.55.3-2.1-2.1-2.31.7-2.0-2.3-1.82.11.7-1.7-1.71.51.71.7-1.3
Pavlov. Cond. index score2.33.14.5-2.0-2.0-2.11.6-1.8-2.1-1.62.01.6-1.6-1.41.31.81.7-1.6
Pavlov. Cond. latency score2.12.84.0-2.0-2.0-1.91.5-1.6-2.0-1.61.81.6-1.4-1.21.01.81.8-1.7
Pavlov. Cond. lever contacts3.64.97.3-2.7-2.7-2.31.9-2.0-2.0-2.41.82.4-2.3-0.81.22.72.6-2.4
Pavlov. Cond. magazine entry number1.72.14.31.61.61.8-1.51.52.11.1-1.9-1.01.11.8-1.2-1.0-1.00.8
Pavlov. Cond. intertrial magazine entries1.32.04.7-1.5-1.5-0.60.60.30.3-1.8-0.92.0-0.71.7-0.52.12.2-1.9
Pavlov. Cond. lever-magazine prob. diff.2.43.24.6-2.1-2.1-2.11.7-1.7-2.1-1.72.01.7-1.5-1.41.21.81.7-1.5
Pavlov. Cond. response bias2.73.65.0-2.1-2.1-2.21.7-2.1-2.2-1.72.21.7-2.0-1.61.51.81.8-1.6
Time in closed arm before self-admin1.31.74.32.11.91.1-1.00.60.71.4-0.3-1.71.0-0.2-0.2-1.7-1.71.5
Time in closed arm after self-admin0.70.82.60.80.80.6-0.70.50.50.9-0.2-1.01.6-0.1-0.5-1.1-1.11.4
Time in open arm before self-admin0.20.20.5-0.2-0.2-0.1-0.00.40.2-0.5-0.40.70.10.6-0.20.50.5-0.6
Time in open arm after self-admin1.21.33.0-1.3-1.2-1.11.5-0.9-0.8-1.30.71.3-1.7-0.30.81.11.1-1.0
Bone: periosteal estimation0.51.02.90.30.31.0-1.50.91.20.2-1.6-0.10.31.7-1.40.50.6-1.2
Bone: periosteal perimeter3.56.012.02.32.33.1-3.12.53.42.1-3.5-2.01.53.0-2.8-1.3-1.20.2
Bone: post-yield work0.50.81.2-1.1-1.1-1.10.6-1.1-0.9-1.00.81.1-0.8-0.81.00.60.6-0.1
Progressive ratio test 1 active lever presses0.40.51.2-0.7-0.7-0.80.5-1.1-0.8-0.50.80.6-0.8-0.80.90.40.4-0.2
Progressive ratio test 1 breakpoint0.40.51.2-0.7-0.7-0.80.5-1.1-0.8-0.50.70.7-0.8-0.80.90.50.4-0.2
Progressive ratio test 1 inactive lever presses0.60.95.1-0.8-0.8-0.4-0.1-1.1-0.5-0.50.30.5-1.1-0.00.01.31.3-2.2
Progressive ratio test 2 active lever presses0.50.51.6-0.1-0.1-0.50.7-1.2-0.8-0.10.90.3-1.2-1.01.30.10.1-0.1
Progressive ratio test 2 breakpoint0.40.51.4-0.0-0.0-0.40.6-1.1-0.8-0.00.90.1-1.1-1.01.20.00.0-0.1
Progressive ratio test 2 inactive lever presses0.10.10.40.40.50.4-0.2-0.30.10.7-0.3-0.4-0.5-0.1-0.0-0.2-0.2-0.2
Incentive Sensitization - Responses0.10.20.50.70.70.40.3-0.00.10.70.1-0.70.0-0.30.1-0.5-0.60.2
Incentive Sensitization - Breakpoint0.20.20.60.70.70.50.2-0.00.10.70.1-0.80.0-0.30.0-0.6-0.60.2
Sum of active levers in priming session hrs 5-60.40.40.8-0.4-0.5-0.70.2-0.9-0.9-0.60.80.4-0.6-0.80.80.40.4-0.5
Progressive ratio0.30.51.70.20.1-0.5-0.1-0.9-0.70.01.10.1-0.4-1.31.2-0.6-0.61.0
Food seeking constrained by brief footshock0.60.71.31.10.90.9-0.80.70.51.1-0.3-1.11.10.0-0.5-1.0-1.00.7
Seeking ratio, punishment vs. effort0.30.41.10.00.00.50.01.00.50.2-0.9-0.40.90.9-1.10.20.2-0.7
Retroperitoneal fat weight0.73.017.3-0.8-0.8-0.4-0.1-1.1-0.4-1.3-0.31.4-2.01.1-0.12.92.9-4.2
Reaction time number correct3.56.78.9-2.7-2.8-2.82.4-2.3-2.8-2.82.62.7-2.4-1.41.93.03.0-2.8
Reaction time mean minus median0.41.11.91.21.31.1-1.00.80.91.1-0.7-1.30.90.2-0.5-1.4-1.41.1
Reaction time mean minus median AUC0.41.12.00.91.01.3-1.41.11.30.9-1.2-1.01.01.0-1.1-0.8-0.70.2
Reaction time num false alarms0.10.10.7-0.1-0.2-0.30.9-0.3-0.3-0.20.60.1-0.2-0.40.3-0.0-0.00.4
Reaction time num false alarms AUC0.20.31.4-0.4-0.5-0.61.2-0.3-0.5-0.50.60.5-0.3-0.40.50.20.20.3
Reaction time trials correct on left3.56.78.9-2.7-2.8-2.82.4-2.3-2.8-2.82.62.7-2.4-1.41.93.03.0-2.8
Reaction time trials on left3.56.69.0-2.7-2.7-2.82.4-2.3-2.8-2.82.62.7-2.4-1.31.83.03.0-2.8
Reaction time mean0.00.10.30.30.30.2-0.5-0.1-0.10.1-0.1-0.2-0.2-0.10.3-0.0-0.0-0.4
Reaction time mean AUC0.10.10.30.30.30.1-0.5-0.3-0.30.10.2-0.2-0.4-0.40.5-0.0-0.0-0.5
Median of all reaction times0.10.10.50.10.1-0.0-0.3-0.2-0.3-0.10.10.0-0.4-0.20.40.30.3-0.7
Reaction time omissions0.81.22.51.21.21.3-1.61.31.20.9-1.2-0.91.01.2-1.1-0.4-0.3-0.5
Reaction time false alarm rate0.71.03.01.00.90.9-0.10.91.01.0-0.7-0.91.00.4-0.5-1.3-1.31.7
Reaction time premature initiation rate1.11.65.2-0.1-0.2-1.21.0-1.8-1.6-0.31.70.3-0.7-2.32.2-0.5-0.61.1
Reaction time premature initiations2.95.29.7-1.7-1.7-2.82.3-2.9-3.1-1.93.01.8-2.1-2.83.11.31.2-0.7
Std. dev. reaction times0.10.20.40.50.60.2-0.40.2-0.10.40.1-0.60.5-0.40.2-0.6-0.60.3
Reaction time trials completed3.56.69.0-2.7-2.7-2.82.4-2.3-2.8-2.82.62.7-2.4-1.31.83.03.0-2.8
Reaction time trials AUC3.87.39.5-2.8-2.8-2.92.5-2.5-2.9-2.92.82.8-2.6-1.52.03.13.0-2.8
Run reversals in cocaine runway, females0.20.20.9-0.2-0.1-0.40.9-0.0-0.70.40.9-0.30.5-0.7-0.30.00.0-0.2
Run reversals in cocaine runway, males0.70.71.81.21.20.9-1.4-0.10.71.1-0.3-1.1-0.10.0-0.0-1.0-1.00.9
Latency to leave start box in cocaine runway0.40.41.30.30.3-0.40.5-0.5-0.70.31.1-0.5-0.0-1.10.6-0.6-0.60.9
Latency to leave start box in cocaine runway, F0.40.51.8-0.2-0.1-0.80.7-0.9-1.0-0.21.30.1-0.6-1.00.80.30.2-0.1
Latency to leave start box in cocaine runway, M0.40.41.90.50.5-0.00.3-0.2-0.10.50.5-0.50.4-0.70.3-0.9-0.91.4
Std. dev. time between licks in bursts1.82.54.0-1.6-1.5-1.61.5-1.3-1.5-1.80.81.8-1.7-0.51.22.02.0-2.0
Total sessions with >9 infusions0.20.20.50.30.3-0.0-0.0-0.1-0.30.70.3-0.30.7-0.70.1-0.6-0.60.7
Short access day 1 total inactive lever presses0.40.51.30.50.60.8-0.61.10.90.3-1.1-0.30.61.2-1.1-0.00.0-0.4
Short access day 10 total inactive lever presses0.51.26.8-0.5-0.50.4-0.50.20.6-0.5-1.00.4-0.71.5-1.41.51.5-2.6
Short access day 1 total infusions0.20.30.70.20.3-0.20.80.0-0.50.70.7-0.30.9-0.8-0.0-0.5-0.50.5
Short access day 10 total infusions0.20.20.7-0.6-0.6-0.20.2-0.7-0.1-0.30.20.4-0.80.00.10.50.5-0.6
Short access total infusions0.10.20.7-0.1-0.1-0.40.2-0.7-0.70.30.70.00.1-0.90.4-0.1-0.10.0
Short access day 1 locomotion0.40.51.50.80.90.4-0.10.40.31.2-0.1-0.61.0-0.2-0.3-0.9-0.91.1
Short access day 10 total locomotion0.10.30.90.60.50.50.00.50.60.2-0.4-0.30.20.4-0.1-0.6-0.61.0
Short access total locomotion0.91.11.81.31.41.0-0.90.70.81.3-0.6-1.11.10.2-0.3-1.3-1.31.3
One hour access (0.3 mA shock)0.70.82.4-0.6-0.5-0.90.4-1.6-1.3-0.21.10.3-1.1-1.51.40.30.2-0.3
Compulsive drug intake0.30.40.8-0.8-0.7-0.5-0.0-0.4-0.4-0.7-0.20.7-0.50.00.20.90.9-0.9
One hour access (shock baseline)0.10.10.5-0.00.0-0.20.2-0.7-0.3-0.00.6-0.0-0.5-0.60.6-0.2-0.20.4
Social response proportion0.10.10.50.40.3-0.1-0.4-0.2-0.40.30.1-0.2-0.1-0.60.7-0.1-0.2-0.2
Social responses0.10.10.40.50.50.3-0.6-0.1-0.10.60.0-0.60.1-0.20.1-0.1-0.2-0.4
Social time0.20.31.10.50.4-0.1-0.4-0.6-0.60.40.3-0.5-0.4-1.10.9-0.4-0.5-0.1
Soleus weight0.41.03.11.21.10.7-1.8-1.40.30.8-0.1-0.8-1.5-0.71.2-0.8-0.90.2
Bone: stiffness1.52.43.91.92.01.8-1.91.31.42.0-1.3-1.91.70.9-1.4-1.2-1.20.2
Tibialis anterior weight0.20.62.00.50.6-0.1-0.2-1.0-0.60.51.0-0.6-0.4-1.41.1-0.8-0.90.6
Time to tail flick, vehicle, before self-admin0.20.21.10.30.40.2-0.30.00.2-0.1-0.1-0.2-0.3-0.20.4-0.6-0.61.1
Time to tail flick, vehicle, after self-admin1.31.83.61.51.61.3-0.51.10.91.6-0.7-1.81.2-0.0-0.6-1.9-1.91.5
Time to tail flick, test, before self-admin0.50.51.5-0.7-0.8-0.71.20.1-0.1-1.00.11.2-0.60.30.50.60.60.1
Time to tail flick, test, after self-admin1.61.74.01.21.11.3-1.12.01.40.7-1.6-0.81.91.4-1.6-0.7-0.60.6
Delta time to tail flick, vehicle, before/after SA0.10.10.8-0.2-0.30.00.6-0.0-0.10.2-0.0-0.1-0.10.1-0.20.30.3-0.9
Delta time to tail flick, test, before/after SA2.82.96.61.91.81.8-1.81.91.31.8-1.4-2.02.60.8-1.8-1.5-1.50.9
Tibia length10.529.046.15.45.46.8-6.85.76.55.2-6.8-5.14.66.2-6.4-2.3-2.1-1.2
Ambulatory time before self-admin0.81.22.01.01.01.4-1.20.81.21.2-1.3-1.30.41.2-1.4-0.0-0.0-1.3
Ambulatory time after self-admin1.41.62.7-1.3-1.3-1.21.0-1.4-1.2-1.10.91.1-1.6-0.61.01.51.5-1.7
Bone: tissue strength0.80.83.4-0.5-0.5-0.50.1-1.7-0.8-0.31.00.3-1.9-0.80.90.60.6-1.2
Total heroin consumption0.30.41.20.30.30.5-0.51.10.7-0.5-1.0-0.00.31.0-0.50.20.2-0.8
Bone: trabecular number0.30.51.3-1.1-1.1-0.80.9-0.1-0.2-1.10.21.2-0.40.20.10.70.70.3
Bone: trabecular spacing0.40.54.80.40.40.0-0.6-0.1-0.70.40.4-0.40.2-0.3-0.10.70.7-2.2
Bone: trabecular thickness0.50.72.5-1.0-1.0-0.60.7-0.90.1-1.10.21.1-1.60.00.70.30.30.9
Bone: trabecular tissue density0.40.61.50.90.90.7-0.61.20.70.7-0.8-0.71.20.5-0.6-0.7-0.70.8
Water consumed over 24 hours0.10.10.3-0.4-0.4-0.20.6-0.20.1-0.30.10.3-0.50.1-0.00.00.00.4
Number of responses in last shaping day1.01.02.51.31.31.1-1.00.70.81.6-0.7-1.11.10.3-0.7-1.1-1.10.7