Hub : Genes

Rassf6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver intron excision ratio chr14_17726571_17726967 0.22 0.09 0.0e+00 0.23 0.24 0.24 0.24 1.4e-25 1.2e-26 1.1e-26 9.5e-27
2 Liver mRNA stability Rassf6 0.03 0.02 4.8e-03 0 0.01 0.01 0 1.3e-01 1.6e-02 9.1e-03 1.0e-01
3 IC gene expression Rassf6 0.3 0.14 2.8e-03 0.03 0.03 0.01 0.02 2.9e-02 1.6e-02 1.7e-01 5.3e-02
4 Liver intron excision ratio chr14_17717648_17726967 0.08 0.04 3.0e-11 0.06 0.09 0.09 0.08 5.3e-07 9.9e-10 3.3e-10 1.4e-09
5 NAcc gene expression Rassf6 0.04 0.02 1.5e-04 0.02 0.03 0.03 0.03 2.7e-04 9.2e-05 3.8e-05 5.1e-05
6 Liver intron excision ratio chr14_17717636_17726967 0.03 0.02 3.9e-04 0.02 0.02 0.01 0.02 2.3e-03 9.9e-04 1.3e-02 6.1e-03
7 Liver gene expression Rassf6 0.46 0.19 0.0e+00 0.15 0.16 0.16 0.16 8.7e-17 1.1e-17 2.8e-17 6.4e-18
8 LHb gene expression Rassf6 0.34 0.12 5.4e-07 0.24 0.25 0.22 0.26 1.6e-06 1.1e-06 5.5e-06 8.1e-07
9 RMTg alternative TSS XM_039091869.2 0.16 0.09 1.9e-03 0.14 0.08 0.12 0.14 1.7e-04 4.2e-03 4.4e-04 2.0e-04
10 Brain alternative TSS XM_008770036.3 0.03 0.02 7.5e-03 0.01 0.01 0 0 1.9e-02 4.0e-02 2.6e-01 3.0e-01
11 Brain gene expression Rassf6 0.08 0.04 1.8e-08 0.1 0.08 0.09 0.09 2.6e-09 5.4e-08 1.7e-08 1.8e-08
12 pVTA gene expression Rassf6 0.26 0.09 4.4e-16 0.2 0.21 0.2 0.19 8.9e-16 1.7e-16 7.1e-16 7.2e-15
13 RMTg alternative TSS XM_008770036.3 0.17 0.1 4.2e-03 0.07 0.07 0.11 0.11 5.1e-03 6.7e-03 9.2e-04 9.2e-04
14 RMTg gene expression Rassf6 0.15 0.09 3.9e-03 0.09 0.06 0.04 0.07 2.4e-03 9.8e-03 3.1e-02 6.4e-03
15 Liver intron excision ratio chr14_17717777_17726967 0.1 0.05 7.3e-10 0.06 0.06 0.05 0.05 7.7e-07 5.2e-07 2.2e-06 1.5e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.51.03.1-1.5-1.6-0.9-1.01.30.41.8-0.10.0-0.00.0-0.30.3-1.31.0
Area under the delay curve0.91.42.8-0.90.5-1.0-1.00.71.4-0.6-1.7-1.5-1.51.5-1.2-1.31.1-1.0
BMI with tail1.13.711.5-2.2-3.4-3.2-3.03.11.71.2-0.5-0.5-0.80.8-1.5-0.3-0.90.9
BMI without tail0.10.62.8-0.6-1.7-1.0-0.91.00.20.50.80.60.1-0.10.00.5-0.60.7
Body weight0.20.82.10.6-1.3-0.70.4-0.1-1.10.41.41.20.8-0.80.10.7-0.71.2
Weight adjusted by age0.10.31.3-0.5-0.1-0.11.1-0.1-0.60.80.30.40.2-0.20.41.2-0.50.7
Bone surface0.61.22.3-0.1-1.30.10.6-0.4-1.11.41.11.31.2-1.20.91.5-1.51.5
Bone volume0.40.83.2-1.1-1.20.1-0.20.6-0.31.80.30.50.5-0.50.40.7-1.51.2
Breakpoint value in progressive ratio session0.20.41.7-0.30.11.30.30.1-0.40.70.50.80.4-0.40.90.5-1.00.5
Number of licking bursts0.00.10.40.60.20.20.5-0.4-0.5-0.50.20.20.3-0.30.10.00.3-0.0
Context. condit. distance diff. score2.83.46.1-2.5-0.7-1.8-2.22.32.30.4-2.1-2.2-2.12.1-2.0-1.80.4-0.6
Locomotion velocity, session 10.80.92.9-1.7-0.7-0.0-1.51.51.01.1-0.9-0.8-0.70.7-0.5-0.7-0.70.2
Locomotion distance, session 12.02.66.4-2.4-0.6-0.9-2.22.51.90.8-1.7-1.7-1.71.7-1.4-1.5-0.1-0.4
Locomotion velocity, session 20.60.72.1-1.4-1.3-0.3-1.21.10.61.1-0.5-0.4-0.20.2-0.4-0.3-0.80.8
Locomotion distance, session 21.01.42.8-1.50.1-0.2-1.71.51.50.1-1.5-1.4-1.41.4-0.9-1.30.5-0.7
Locomotion velocity, session 31.41.63.7-1.9-0.2-1.0-1.21.81.50.7-1.5-1.5-1.51.5-1.4-1.30.0-0.4
Locomotion distance, session 32.12.47.4-2.7-1.0-0.9-2.12.61.81.1-1.4-1.5-1.41.4-1.2-1.1-0.50.0
Stereotopy head waving bouts, day 30.40.51.3-1.20.50.4-0.50.50.80.5-1.0-0.9-0.90.9-0.5-0.90.1-0.5
Stereotopy head waving duration, day 30.70.81.3-0.41.0-0.5-0.30.31.0-0.4-1.2-1.1-1.11.1-1.0-1.10.9-1.1
Locomotion velocity, session 71.01.01.8-0.80.8-0.5-1.01.11.3-0.3-1.4-1.3-1.21.2-1.1-1.10.7-1.1
Locomotion distance, session 70.40.50.9-0.60.8-0.2-0.60.90.9-0.3-0.9-0.9-0.70.7-0.6-0.60.4-0.8
Stereotopy head waving bouts, day 70.50.62.6-1.5-1.10.8-0.40.70.11.6-0.00.1-0.10.10.40.1-1.20.8
Stereotopy head waving duration, day 70.10.10.7-0.9-0.20.5-0.30.30.20.8-0.2-0.1-0.20.20.2-0.2-0.40.1
Locomotion velocity, session 83.74.59.1-2.3-0.9-2.6-3.02.82.80.2-2.3-2.3-2.22.2-2.3-1.80.6-0.9
Locomotion distance, session 83.55.19.9-3.1-1.1-2.1-3.03.02.80.6-2.5-2.6-2.42.4-2.3-2.00.3-0.6
Degree of sensitization distance1.21.25.32.31.20.41.3-1.7-1.0-1.40.80.80.9-0.90.60.60.8-0.5
Degree of sensitization stereotypy0.20.20.8-0.8-0.60.6-0.20.3-0.10.90.10.20.1-0.10.30.1-0.70.5
Conditioned locomotion0.50.62.30.81.5-0.40.5-0.30.2-1.5-0.1-0.3-0.20.2-0.3-0.31.2-1.2
Cocaine response after cond. corrected0.10.10.50.60.50.70.50.0-0.4-0.10.10.20.2-0.20.40.20.2-0.3
Cocaine response after cond. not corrected0.20.30.50.4-0.70.30.30.3-0.60.60.50.70.7-0.70.50.7-0.60.5
Cocaine response before conditioning1.11.35.7-0.3-2.4-1.0-0.10.2-0.71.20.91.01.0-1.00.31.2-1.51.7
Saline control response0.20.31.3-1.1-0.40.6-0.30.50.30.8-0.1-0.1-0.00.00.30.1-0.80.4
Bone: connectivity density0.50.83.2-1.1-1.5-1.8-1.11.10.60.9-0.4-0.3-0.30.3-0.80.1-0.70.6
Bone: cortical apparent density0.50.73.1-1.8-0.00.5-1.01.10.91.0-0.9-0.7-0.80.8-0.3-0.8-0.50.0
Bone: cortical area0.40.72.8-0.8-1.3-0.0-0.10.7-0.31.70.30.50.4-0.40.40.8-1.31.1
Bone: cortical porosity0.30.31.00.60.6-0.30.00.10.4-1.0-0.3-0.3-0.50.5-0.4-0.40.9-1.0
Bone: cortical porosity0.20.20.91.00.3-0.30.5-0.2-0.2-0.80.30.20.1-0.1-0.10.10.6-0.5
Bone: cortical thickness0.91.64.8-2.0-2.1-0.7-1.31.80.52.2-0.10.1-0.00.00.10.6-1.71.3
Bone: cortical thickness0.70.91.6-0.2-0.91.10.4-0.0-0.81.21.01.01.0-1.01.21.1-1.31.0
Bone: cortical tissue density0.40.72.9-1.7-0.10.5-1.01.00.91.0-0.8-0.7-0.80.8-0.3-0.8-0.50.1
Condit. Reinf. active minus inactive responses0.20.21.00.00.21.00.7-0.7-0.50.30.30.30.2-0.20.50.0-0.40.4
Condit. Reinf. active-inactive response ratio0.50.53.00.30.81.70.9-0.9-0.60.30.50.50.4-0.41.00.2-0.30.2
Condit. Reinf. active responses0.10.10.4-0.70.00.70.1-0.00.00.6-0.1-0.1-0.20.20.1-0.3-0.50.4
Condit. Reinf. inactive responses0.20.20.7-0.8-0.8-0.5-0.50.70.20.6-0.1-0.2-0.10.1-0.3-0.0-0.50.5
Incentive salience index mean0.10.10.2-0.40.10.1-0.10.00.30.2-0.3-0.3-0.40.4-0.2-0.5-0.1-0.0
Condit. Reinf. lever presses0.00.10.2-0.5-0.2-0.4-0.20.20.30.2-0.1-0.2-0.20.2-0.3-0.1-0.20.0
Condit. Reinf. active minus inactive responses0.40.72.6-1.6-1.20.4-0.80.90.31.6-0.2-0.2-0.20.20.1-0.1-1.10.9
Condit. Reinf. active-inactive response ratio1.01.62.30.7-0.71.01.3-1.1-1.50.91.51.41.5-1.51.41.4-1.21.4
Condit. Reinf. active responses0.71.03.9-2.0-0.60.3-1.21.40.81.4-0.9-0.8-0.90.9-0.4-0.8-0.70.4
Condit. Reinf. inactive responses0.91.32.8-1.70.1-0.3-1.51.51.40.3-1.3-1.3-1.41.4-1.0-1.20.3-0.6
Condit. Reinf. lever presses0.20.30.80.40.3-0.90.2-0.20.1-0.8-0.4-0.5-0.50.5-0.8-0.50.9-0.5
Condit. Reinf. lever reinforcers received0.81.14.1-2.0-0.70.1-1.31.40.91.3-1.0-0.9-1.01.0-0.6-0.9-0.60.3
Conditioned reinforcement - actives0.10.31.0-0.90.40.5-0.31.00.50.5-0.6-0.5-0.50.5-0.2-0.90.1-0.2
Conditioned reinforcement - inactives0.10.21.40.60.2-0.20.80.1-0.7-0.21.20.70.1-0.1-0.0-0.20.00.2
Conditioned locomotion0.50.73.40.71.80.90.4-0.1-0.1-1.0-0.0-0.2-0.60.6-0.3-1.30.9-1.1
Patch foraging indifference point 0 sec0.30.81.6-0.8-0.6-1.3-1.10.81.00.2-0.9-0.7-1.11.1-1.2-1.10.1-0.1
Patch foraging indifference point AUC0.20.61.40.60.9-1.20.20.30.3-1.1-0.4-0.7-0.40.4-1.0-0.41.2-1.1
Delay disc. indifference point, 0s delay0.20.30.8-0.9-0.3-0.2-0.60.70.60.3-0.6-0.6-0.50.5-0.4-0.70.00.0
Delay disc. indifference point, 16s delay0.60.92.1-0.5-0.4-1.4-1.10.41.1-0.7-1.1-1.1-1.11.1-1.0-0.90.9-0.6
Delay disc. indifference point, 2s delay0.80.92.0-0.21.4-0.3-0.30.30.9-1.0-1.2-1.0-1.01.0-0.9-1.01.0-1.3
Delay disc. indifference point, 24s delay1.01.63.4-0.01.2-1.1-0.10.11.0-1.2-1.6-1.6-1.41.4-1.5-1.61.8-1.5
Delay disc. indifference point, 4s delay2.82.95.2-1.80.7-0.9-1.81.92.1-0.4-2.3-2.1-2.12.1-1.7-2.10.9-1.4
Delay disc. indifference point, 8s delay0.20.31.0-0.90.2-0.3-0.50.60.70.2-1.0-0.7-0.60.6-0.3-0.40.2-0.3
Indifference point function ln k0.20.73.2-0.4-1.80.6-0.6-0.0-0.41.00.50.70.5-0.50.90.6-1.11.2
Indifference point function log k0.20.73.2-0.4-1.80.6-0.6-0.0-0.41.00.50.70.5-0.50.90.6-1.11.2
Patch foraging total patch changes 0 sec0.30.81.4-0.7-0.4-1.2-1.00.91.1-0.0-0.9-0.8-1.11.1-1.2-1.10.3-0.3
Patch foraging total patch changes 12 sec1.21.62.5-0.60.6-1.4-1.31.21.5-0.9-1.6-1.4-1.41.4-1.5-1.31.1-1.3
Patch foraging total patch changes 18 sec0.00.10.2-0.0-0.00.30.10.0-0.30.50.10.30.2-0.20.10.1-0.50.3
Patch foraging total patch changes 24 sec0.82.84.8-1.30.7-1.3-2.02.21.9-0.5-1.6-1.8-2.02.0-2.0-2.11.1-1.4
Patch foraging total patch changes 6 sec1.52.54.4-0.50.7-2.0-1.41.21.8-1.0-1.7-1.7-1.81.8-2.1-1.91.4-1.6
Patch foraging time to switch 0 sec0.20.82.1-0.4-0.70.90.3-0.7-0.51.40.40.80.9-0.91.11.0-1.41.1
Patch foraging water rate 0 sec0.20.62.61.00.8-0.60.20.10.1-1.60.0-0.3-0.50.5-0.7-0.61.3-1.0
Patch foraging water rate 12 sec0.31.12.1-0.31.0-0.4-0.70.71.1-1.0-0.7-1.1-1.41.4-1.1-1.21.1-1.4
Patch foraging water rate 18 sec0.10.30.9-0.30.0-0.1-0.90.50.5-0.4-0.2-0.5-0.70.7-0.6-0.80.4-0.4
Patch foraging water rate 24 sec0.20.31.70.20.51.30.6-0.3-0.7-0.20.70.50.3-0.30.60.1-0.40.2
Patch foraging water rate 6 sec0.81.22.50.41.3-0.1-0.50.30.8-1.4-0.9-1.1-1.31.3-1.0-1.41.6-1.6
Seeking ratio, delayed vs. immediate footshock0.40.61.4-0.00.90.1-0.60.60.8-0.8-0.5-0.9-0.90.9-0.6-1.01.1-1.2
Distance traveled before self-admin0.40.93.31.21.80.30.6-0.90.0-1.8-0.5-0.3-0.50.5-0.1-0.31.3-1.2
Distance traveled after self-admin0.91.65.4-0.22.31.5-0.30.30.7-1.3-1.1-1.2-1.21.2-0.3-1.41.4-1.7
Extensor digitorum longus weight2.18.336.3-3.1-6.0-2.2-2.42.40.24.41.11.21.3-1.30.72.3-3.93.8
Bone: elastic displacement0.81.02.9-0.8-1.7-0.0-0.50.3-0.31.70.60.80.8-0.80.71.1-1.61.4
Bone: elastic work1.41.85.0-0.9-2.10.3-0.50.4-0.62.21.01.21.2-1.21.11.5-2.11.9
Bone: endosteal estimation0.51.34.11.41.12.01.5-1.4-1.4-0.20.90.91.0-1.01.20.70.00.1
Bone: endosteal perimeter0.51.23.31.30.41.01.8-1.5-1.50.11.01.11.2-1.20.91.1-0.30.5
Epididymis fat weight0.20.82.30.50.8-0.7-0.60.10.6-1.4-0.9-0.7-1.01.0-0.7-0.91.5-1.3
Delta time in closed arm before/after self-admin0.20.20.6-0.1-0.1-0.6-0.40.20.50.0-0.8-0.7-0.10.1-0.4-0.30.2-0.2
Delta time in open arm before/after self-admin0.70.83.21.51.1-0.70.3-1.10.1-1.8-0.1-0.4-0.10.1-0.20.11.5-0.9
Diff in mean of infusions in LGA sessions1.52.75.10.6-0.22.31.4-1.2-1.81.31.72.01.7-1.72.21.7-1.81.6
Delay discount exponential model param1.21.63.20.8-0.81.10.9-0.7-1.50.81.81.61.6-1.61.41.4-1.21.2
Extinction: sum of active levers before priming0.20.41.50.51.20.5-0.20.40.2-0.9-0.10.0-0.40.4-0.4-1.00.4-1.0
Active lever presses in extinction session 60.60.61.71.31.30.90.8-0.9-0.6-1.00.70.3-0.20.20.3-0.20.6-0.5
Bone: final force0.30.50.80.70.20.90.8-0.6-0.90.20.70.70.7-0.70.80.9-0.30.3
Bone: final moment0.30.51.20.70.41.10.9-0.7-0.90.00.70.70.7-0.70.90.8-0.20.2
Food consumed during 24 hour testing period0.10.10.6-0.2-0.5-0.8-0.50.50.3-0.0-0.2-0.2-0.20.2-0.4-0.1-0.0-0.0
Glucose0.20.31.4-0.21.01.20.2-0.30.2-0.4-0.5-0.5-0.40.40.1-0.70.6-0.7
Heart weight0.50.91.91.2-1.4-1.10.4-0.8-0.8-0.31.31.30.8-0.80.41.1-0.30.9
Delay discount hyperbolic model param1.51.93.70.9-0.91.31.0-0.8-1.60.91.91.71.7-1.71.51.6-1.31.4
Intermittent access intake day 1-15 change0.00.10.5-0.4-0.00.7-0.10.1-0.10.20.70.0-0.20.20.3-0.3-0.10.5
Intermittent access intake escalation0.00.10.5-0.5-0.10.7-0.20.1-0.10.30.70.1-0.10.10.4-0.2-0.20.5
Intermittent access intake escalation 20.20.41.60.11.30.7-0.30.10.2-0.70.2-0.3-0.50.5-0.2-1.00.7-0.6
Intermitt. access day 1 inactive lever presses0.22.35.8-2.1-1.6-2.0-2.02.41.60.5-1.0-1.2-1.31.3-1.7-1.30.1-0.0
Intermitt. access day 15 inactive lever presses0.10.82.11.20.2-0.11.3-0.8-1.2-0.71.51.30.8-0.80.40.6-0.20.4
Intermitt. access escalation Index0.82.44.91.2-0.22.21.1-1.6-1.70.51.41.82.0-2.02.21.8-1.21.0
Intermittent access day 1 total infusions0.10.21.41.20.3-0.10.3-0.5-0.4-0.70.30.20.3-0.3-0.1-0.10.6-0.4
Intermittent access day 15 total infusions0.10.30.70.30.80.3-0.20.10.1-0.70.1-0.4-0.50.5-0.3-0.80.8-0.6
Intermittent access terminal intake (last 3 days)0.50.92.51.01.50.1-0.2-0.10.3-1.6-0.0-0.6-0.70.7-0.7-1.31.6-1.3
Intermittent access total infusions0.40.51.71.10.90.0-0.0-0.4-0.0-1.30.3-0.3-0.30.3-0.4-0.81.2-0.9
Intermittent access day 1 locomotion0.00.10.40.60.10.20.3-0.3-0.4-0.10.30.30.2-0.2-0.0-0.10.1-0.0
Intermittent access day 15 total locomotion0.72.85.1-0.30.8-1.7-0.91.11.5-1.8-1.5-1.7-2.32.3-2.1-2.12.1-1.8
Intermittent access total locomotion0.50.62.01.41.10.20.4-0.7-0.3-1.40.4-0.1-0.20.2-0.2-0.61.1-0.8
Intermittent access standard deviation0.20.92.3-0.4-0.1-0.9-0.80.50.9-0.6-0.3-1.0-1.51.5-1.1-1.21.0-0.7
Left kidney weight0.11.12.41.1-1.2-0.81.1-0.9-1.3-0.21.51.31.1-1.10.41.2-0.41.0
Right kidney weight0.42.77.12.7-0.0-0.52.6-2.2-2.3-1.12.11.81.5-1.50.61.40.20.6
Cocaine induced anxiety1.95.39.01.10.12.82.4-2.0-2.71.22.52.72.8-2.83.02.6-1.91.9
Post-drug Anxiety2.42.85.40.4-0.42.11.4-1.3-1.71.31.41.82.0-2.02.32.2-1.61.6
Baseline Anxiety1.22.14.9-1.4-0.1-1.1-1.71.41.9-0.2-2.2-1.9-1.61.6-1.4-1.40.9-1.1
Tail length0.74.012.12.93.52.82.8-2.8-1.9-1.91.20.90.7-0.71.30.21.5-1.3
Length with tail1.67.017.63.93.13.04.2-4.1-3.3-1.52.32.02.0-2.01.91.20.8-0.1
Length without tail0.21.22.81.40.50.81.6-1.4-1.7-0.01.11.01.2-1.20.70.8-0.20.7
Times rat made contact with spout0.80.93.81.80.8-1.40.5-0.6-0.1-1.90.40.10.1-0.1-0.50.11.3-1.0
Lifetime Intake0.30.41.41.20.90.20.2-0.5-0.2-1.10.4-0.1-0.00.0-0.3-0.60.9-0.8
Liver weight, left0.91.54.00.91.4-0.4-0.70.40.9-2.0-0.9-1.0-1.21.2-1.1-1.41.8-1.9
Liver weight, right1.73.06.5-0.12.20.3-1.41.11.7-1.7-2.0-1.9-1.91.9-1.2-2.01.9-2.6
Locomotor activity0.40.61.80.10.1-1.3-0.60.60.7-0.8-0.7-0.8-0.80.8-1.1-0.71.0-0.7
Locomotor testing distance0.51.22.7-0.9-0.2-1.6-1.31.31.2-0.5-0.8-1.1-1.31.3-1.4-0.90.9-0.6
Locomotor testing rearing0.31.12.8-1.6-0.7-1.3-1.21.71.10.1-0.6-0.9-1.11.1-1.3-1.00.2-0.1
Locomotion in novel chamber0.71.02.3-0.50.7-0.5-0.60.51.0-0.5-1.2-1.5-1.41.4-1.0-1.01.1-0.9
Locomotion in novel chamber post-restriction0.31.04.50.7-0.2-2.1-0.2-0.20.4-1.3-0.4-0.7-0.90.9-1.5-1.01.2-0.6
Fecal boli incidents, locomotor time 10.10.31.30.50.50.61.1-0.5-0.6-0.40.40.40.3-0.30.70.9-0.20.0
Change in fecal boli incidents, locomotor task1.31.33.60.60.21.91.2-1.4-1.21.01.11.21.2-1.21.50.9-1.00.8
Time >=10cm from walls, locomotor time 11.01.22.10.4-0.11.21.3-1.0-1.40.81.21.31.2-1.21.31.2-1.21.1
Bouts of movement, locomotor time 10.20.31.20.80.7-0.20.2-0.20.1-1.10.2-0.3-0.40.4-0.2-0.20.8-0.8
Total resting periods, locomotor time 10.40.41.60.91.30.50.4-0.50.0-1.10.2-0.2-0.30.30.1-0.10.9-1.0
Rest time, locomotor task time 10.50.92.61.41.41.61.1-1.1-0.6-0.70.60.40.7-0.71.00.40.5-0.5
Distance moved, locomotor task time 10.00.10.5-0.00.0-0.7-0.20.1-0.0-0.20.20.10.2-0.2-0.3-0.00.1-0.0
Vertical activity count, locomotor time 10.10.41.40.00.0-1.2-0.50.30.5-0.6-0.7-0.6-0.70.7-1.0-0.60.8-0.4
Time >=10cm from walls, locomotor time 20.31.01.7-0.0-0.21.21.1-0.4-1.01.11.01.10.9-0.91.31.0-1.31.1
Bouts of movement, locomotor time 20.41.42.3-0.50.8-1.0-0.60.61.3-1.1-1.4-1.5-1.51.5-1.4-1.31.3-1.2
Total resting periods, locomotor time 20.21.01.5-0.10.7-1.0-0.50.41.0-1.2-1.2-1.2-1.21.2-1.2-1.01.2-1.1
Rest time, locomotor task time 20.71.34.41.42.1-0.10.5-0.30.4-2.1-0.6-0.6-0.60.6-0.5-0.51.6-1.8
Distance moved, locomotor task time 20.60.92.0-0.7-1.40.2-0.40.1-0.51.31.00.91.0-1.00.70.6-1.31.4
Vertical activity count, locomotor time 20.20.41.5-0.9-1.00.5-0.50.2-0.11.20.10.20.2-0.20.30.0-0.80.9
Light reinforcement 10.21.15.40.2-0.1-2.3-0.40.20.7-1.0-0.8-0.7-1.11.1-1.8-0.91.1-0.8
Light reinforcement 20.81.76.10.30.6-2.5-0.30.71.1-1.3-1.0-1.1-1.51.5-2.0-1.11.4-1.5
Bone: marrow area0.51.23.61.31.01.91.4-1.3-1.4-0.20.90.91.0-1.01.20.70.00.1
Bone: maximum diameter0.71.42.40.6-0.90.71.1-0.8-1.41.11.31.41.4-1.41.21.5-1.21.3
Bone: maximum force0.10.30.60.60.10.50.8-0.5-0.70.20.50.60.5-0.50.50.7-0.20.1
Bone: maximum moment0.20.30.80.60.40.70.9-0.6-0.80.10.50.50.5-0.50.60.7-0.10.0
Mean time between licks in bursts0.10.82.11.30.71.11.1-1.5-1.0-0.80.90.70.7-0.70.80.50.4-0.1
Mean num. licks in bursts0.10.41.00.50.7-0.9-0.20.10.6-1.0-0.2-0.4-0.50.5-0.6-0.20.8-1.0
Cd content in liver3.23.55.70.7-1.71.21.0-0.9-1.91.42.32.32.3-2.32.32.4-2.02.2
Co content in liver0.30.41.1-0.2-0.50.40.7-0.3-0.90.50.60.70.7-0.70.50.6-0.81.1
Cu content in liver0.10.10.2-0.40.30.0-0.30.50.3-0.2-0.4-0.3-0.40.4-0.4-0.40.1-0.4
Fe content in liver0.80.91.60.1-0.60.91.2-0.8-1.20.81.21.10.9-0.90.90.8-1.31.2
K content in liver2.32.33.8-1.21.1-1.0-1.31.21.8-1.0-1.9-1.8-1.81.8-1.6-1.81.2-1.7
Mg content in liver0.50.62.2-0.11.5-0.20.00.00.5-1.0-0.9-0.7-0.60.6-0.6-0.60.8-1.2
Mn content in liver0.70.73.8-1.9-1.2-0.0-0.70.90.61.4-0.5-0.4-0.20.20.10.1-1.20.8
Na content in liver3.94.47.0-1.01.3-1.9-1.51.42.4-1.4-2.6-2.6-2.42.4-2.5-2.41.9-2.4
Rb content in liver0.91.02.80.30.31.70.9-1.0-1.10.61.01.11.1-1.11.41.0-0.80.8
Se content in liver1.11.32.4-0.40.5-1.4-0.40.01.2-0.9-1.3-1.4-1.41.4-1.5-1.41.1-1.1
Sr content in liver1.41.23.20.2-1.8-0.00.4-0.2-1.00.71.31.11.3-1.30.91.5-1.21.4
Zn content in liver0.30.30.6-0.7-0.1-0.3-0.80.70.7-0.2-0.5-0.4-0.70.7-0.4-0.70.1-0.4
Bone: minimum diameter0.91.75.02.02.21.62.1-1.6-1.4-1.10.50.50.6-0.60.60.30.9-0.8
Time in familiar zone, hab. session 11.41.62.6-1.5-0.5-1.5-1.41.41.6-0.1-1.5-1.4-1.31.3-1.4-1.10.5-0.9
Time in novel zone, hab. session 12.83.17.22.71.82.42.2-2.6-2.0-0.91.71.61.4-1.41.81.00.20.1
Total zone transitions, hab. session 12.94.16.4-1.80.5-1.5-2.32.12.5-0.6-2.4-2.4-2.52.5-2.3-2.51.2-1.5
Total locomotion distance, hab. session 14.05.78.0-0.81.6-2.1-1.91.92.7-2.1-2.6-2.7-2.72.7-2.8-2.82.5-2.7
Locomotion velocity, hab. session 14.15.88.5-1.40.9-2.5-2.22.52.8-1.6-2.7-2.8-2.72.7-2.9-2.72.1-2.3
Time in familiar zone, hab. session 20.50.61.90.71.2-1.00.7-0.50.1-1.4-0.1-0.3-0.20.2-0.6-0.21.1-1.1
Time in novel zone, hab. session 20.60.72.2-0.0-1.11.5-0.3-0.1-0.51.00.60.70.5-0.51.10.5-0.91.1
Total zone transitions, hab. session 20.20.20.7-0.3-0.5-0.4-0.80.50.60.0-0.5-0.4-0.40.4-0.3-0.40.1-0.0
Total locomotion distance, hab. session 20.50.71.10.00.4-0.9-0.60.50.9-1.0-0.8-0.9-0.90.9-0.9-0.91.1-0.9
Locomotion velocity, hab. session 21.11.42.0-0.40.4-1.3-1.11.01.4-1.0-1.4-1.4-1.31.3-1.4-1.31.3-1.3
Novel to familiar place preference ratio0.30.30.7-0.20.2-0.7-0.20.40.5-0.5-0.7-0.7-0.60.6-0.8-0.60.6-0.6
Novelty place preference0.30.40.80.10.4-0.8-0.00.30.4-0.9-0.7-0.7-0.60.6-0.9-0.60.9-0.8
Time in novel zone, NPP test0.40.51.00.00.6-0.6-0.10.30.5-1.0-0.8-0.8-0.70.7-0.9-0.81.0-0.9
Total zone transitions, NPP test0.71.03.1-1.8-1.7-0.1-1.21.50.61.4-0.3-0.3-0.20.2-0.0-0.1-1.11.0
Total locomotion distance, NPP test0.81.22.3-1.0-0.4-1.5-1.01.51.3-0.3-1.1-1.2-1.21.2-1.4-1.10.6-0.6
Locomotion velocity, NPP test0.81.13.0-1.3-1.0-1.5-1.11.71.20.2-1.0-1.0-1.01.0-1.2-0.90.1-0.1
Intraocular pressure0.81.36.72.60.60.11.0-1.8-1.1-1.61.20.70.8-0.80.40.41.0-0.2
Delta distance traveled before/after self-admin0.70.73.0-1.70.41.3-0.81.10.70.8-0.7-0.8-0.70.7-0.1-0.8-0.2-0.3
Delta ambulatory time before/after self-admin0.50.83.7-1.80.01.9-0.81.10.51.4-0.5-0.4-0.20.20.5-0.5-0.70.2
Parametrial fat weight0.10.31.11.00.2-0.40.9-0.6-0.6-0.90.60.3-0.40.4-0.3-0.10.5-0.0
Pavlov. Cond. lever latency0.81.01.80.6-0.20.71.3-1.0-1.20.61.11.21.2-1.21.01.2-0.90.9
Pavlov. Cond. magazine entry latency0.60.81.8-0.4-0.2-1.2-1.30.81.1-0.3-1.0-1.0-0.90.9-1.0-0.90.8-0.7
Pavlov. Cond. change in total contacts0.30.40.8-0.9-0.10.2-0.90.70.70.4-0.7-0.7-0.70.7-0.3-0.60.1-0.3
Pavlov. Cond. index score1.31.73.8-1.10.0-0.8-1.91.51.7-0.2-1.5-1.5-1.51.5-1.2-1.40.8-1.0
Pavlov. Cond. latency score0.91.22.7-0.90.0-0.7-1.61.31.4-0.2-1.2-1.2-1.31.3-1.0-1.20.7-0.9
Pavlov. Cond. lever contacts0.70.92.6-1.1-0.2-0.4-1.61.31.20.1-1.1-1.0-1.11.1-0.8-1.00.4-0.5
Pavlov. Cond. magazine entry number0.70.92.20.90.20.61.5-0.9-1.2-0.21.11.01.1-1.10.91.0-0.50.6
Pavlov. Cond. intertrial magazine entries0.81.02.1-1.10.3-0.3-1.11.41.20.2-1.2-1.2-1.21.2-0.9-1.10.3-0.6
Pavlov. Cond. lever-magazine prob. diff.1.41.84.0-1.1-0.0-1.0-2.01.51.7-0.2-1.6-1.5-1.51.5-1.3-1.40.9-1.0
Pavlov. Cond. response bias1.11.32.6-0.90.1-0.7-1.61.11.4-0.1-1.4-1.4-1.41.4-1.2-1.40.8-1.0
Pavlov. Cond. lever latency0.50.73.8-1.2-0.31.9-0.40.40.11.40.00.20.2-0.20.90.0-1.10.5
Pavlov. Cond. magazine entry latency0.71.12.91.70.3-0.11.5-1.6-1.2-0.91.21.01.0-1.00.60.90.30.3
Pavlov. Cond. change in total contacts0.30.63.40.70.2-1.8-0.20.00.4-1.2-0.3-0.5-0.50.5-1.0-0.41.1-0.7
Pavlov. Cond. index score0.60.93.41.80.4-1.01.2-1.4-1.0-1.30.90.70.7-0.70.00.70.8-0.1
Pavlov. Cond. latency score0.60.92.81.70.2-0.81.2-1.3-1.0-1.01.00.90.9-0.90.31.00.40.2
Pavlov. Cond. lever contacts0.60.83.21.50.6-1.80.6-0.6-0.2-1.7-0.0-0.2-0.20.2-0.9-0.11.3-0.7
Pavlov. Cond. magazine entry number0.71.02.0-1.4-0.10.1-1.31.41.20.5-1.2-1.1-1.11.1-0.7-1.1-0.0-0.5
Pavlov. Cond. intertrial magazine entries0.00.10.3-0.5-0.10.2-0.30.60.20.2-0.3-0.3-0.40.4-0.2-0.5-0.20.1
Pavlov. Cond. lever-magazine prob. diff.0.71.03.81.90.4-1.21.2-1.4-1.0-1.50.90.70.7-0.7-0.00.70.9-0.1
Pavlov. Cond. response bias0.50.72.41.50.7-1.40.7-0.9-0.3-1.60.1-0.0-0.00.0-0.7-0.11.3-0.6
Time in closed arm before self-admin0.61.02.80.3-1.6-0.10.7-0.2-1.10.51.71.30.9-0.90.60.9-0.91.5
Time in closed arm after self-admin0.60.72.9-1.2-1.7-1.1-0.71.10.41.0-0.5-0.5-0.00.0-0.6-0.1-0.60.9
Time in open arm before self-admin0.50.74.3-0.91.42.10.5-0.1-0.11.0-0.6-0.10.2-0.20.7-0.1-0.7-0.2
Time in open arm after self-admin1.82.08.31.72.90.00.6-1.20.3-2.4-0.9-0.8-0.70.7-0.4-0.72.0-2.0
Bone: periosteal estimation0.40.91.60.4-0.11.31.0-0.6-1.20.90.91.01.0-1.01.11.1-0.90.8
Bone: periosteal perimeter0.10.10.40.0-0.3-0.10.4-0.0-0.50.60.20.40.4-0.40.10.6-0.50.4
Bone: post-yield work0.91.65.32.31.90.32.0-1.9-1.0-1.70.60.50.5-0.50.30.41.3-1.0
Progressive ratio test 1 active lever presses0.81.54.92.22.10.11.0-1.1-0.4-2.00.2-0.3-0.40.4-0.5-0.71.7-1.5
Progressive ratio test 1 breakpoint0.81.44.42.12.10.20.9-1.1-0.4-2.00.1-0.3-0.40.4-0.5-0.81.7-1.5
Progressive ratio test 1 inactive lever presses0.10.31.20.2-0.0-1.1-0.20.40.2-0.70.30.1-0.60.6-0.8-0.60.5-0.5
Progressive ratio test 2 active lever presses0.71.04.81.52.20.30.7-0.5-0.2-1.50.3-0.3-0.50.5-0.4-0.81.4-1.4
Progressive ratio test 2 breakpoint0.81.04.51.42.10.20.7-0.5-0.1-1.40.2-0.3-0.50.5-0.5-0.81.4-1.4
Progressive ratio test 2 inactive lever presses0.20.62.11.01.4-0.20.7-0.2-0.1-1.50.5-0.0-0.50.5-0.5-0.71.1-1.0
Incentive Sensitization - Responses0.10.31.20.91.10.60.7-0.5-0.6-0.50.80.40.2-0.20.30.10.4-0.2
Incentive Sensitization - Breakpoint0.10.31.01.01.00.50.7-0.6-0.7-0.50.80.50.3-0.30.30.10.4-0.2
Sum of active levers in priming session hrs 5-60.30.31.4-0.01.2-0.10.10.40.5-0.6-0.3-0.4-0.70.7-0.4-0.60.4-0.9
Progressive ratio0.00.10.6-0.4-0.50.1-0.30.8-0.00.50.1-0.20.4-0.40.00.1-0.30.4
Food seeking constrained by brief footshock0.40.61.6-0.3-1.30.3-0.50.6-0.41.01.00.70.6-0.60.30.3-1.11.1
Seeking ratio, punishment vs. effort0.00.10.30.40.60.30.1-0.50.0-0.40.20.2-0.30.30.1-0.10.2-0.4
Retroperitoneal fat weight0.10.61.51.10.21.00.9-1.2-1.1-0.11.00.80.4-0.40.80.5-0.20.5
Reaction time number correct0.20.71.61.10.00.81.0-1.3-1.00.00.70.80.9-0.90.90.7-0.40.6
Reaction time mean minus median0.11.02.91.70.30.71.4-1.2-1.3-0.31.11.31.0-1.00.80.60.00.1
Reaction time mean minus median AUC0.21.55.72.40.50.71.3-1.5-1.4-0.81.31.61.3-1.31.00.80.3-0.1
Reaction time num false alarms1.11.83.1-1.30.7-0.8-1.61.21.8-0.7-1.6-1.4-1.61.6-1.3-1.61.2-1.4
Reaction time num false alarms AUC0.81.93.3-1.30.5-0.9-1.71.11.8-0.7-1.7-1.5-1.61.6-1.4-1.71.2-1.3
Reaction time trials correct on left0.20.71.61.10.00.81.0-1.3-1.00.00.70.80.9-0.90.90.7-0.40.6
Reaction time trials on left0.20.81.71.1-0.10.91.0-1.3-1.10.10.80.90.9-0.91.00.8-0.50.7
Reaction time mean0.81.82.71.2-0.11.61.6-1.5-1.60.51.51.61.5-1.51.61.3-0.70.8
Reaction time mean AUC0.51.32.41.20.11.61.5-1.5-1.40.21.21.31.1-1.11.40.9-0.40.5
Median of all reaction times1.11.72.70.9-0.21.61.5-1.5-1.50.71.41.41.4-1.41.61.3-0.81.0
Reaction time omissions1.42.34.10.1-1.41.60.7-0.6-1.51.71.61.81.6-1.61.81.5-2.01.9
Reaction time false alarm rate2.02.74.3-1.50.7-1.4-1.91.42.1-0.9-1.8-1.8-1.91.9-1.7-1.91.5-1.6
Reaction time premature initiation rate0.40.61.7-0.40.6-0.5-0.40.10.9-0.3-0.6-0.8-1.31.3-0.8-1.00.5-0.8
Reaction time premature initiations0.10.20.70.30.5-0.10.0-0.50.3-0.3-0.2-0.3-0.80.8-0.4-0.60.3-0.4
Std. dev. reaction times0.31.01.91.20.01.41.1-1.0-1.20.21.21.31.0-1.01.10.7-0.40.4
Reaction time trials completed0.20.81.71.1-0.10.91.0-1.3-1.10.10.80.90.9-0.91.00.8-0.50.7
Reaction time trials AUC0.31.12.01.3-0.11.21.1-1.4-1.30.20.91.11.1-1.11.20.9-0.60.8
Run reversals in cocaine runway, females0.20.31.5-1.2-0.20.1-0.81.00.50.4-0.1-0.3-0.30.3-0.4-0.4-0.10.0
Run reversals in cocaine runway, males1.41.63.00.9-1.30.50.9-1.0-1.30.71.71.61.6-1.61.31.3-1.01.3
Latency to leave start box in cocaine runway0.40.51.80.9-0.2-1.30.3-0.7-0.0-1.1-0.5-0.5-0.40.4-0.9-0.60.9-0.3
Latency to leave start box in cocaine runway, F0.91.23.30.30.1-1.8-0.30.10.7-1.4-1.2-1.1-1.01.0-1.7-1.31.3-1.0
Latency to leave start box in cocaine runway, M0.90.82.11.2-0.70.41.0-1.5-1.20.10.90.90.9-0.90.91.0-0.40.9
Std. dev. time between licks in bursts0.10.20.90.30.6-0.00.00.00.2-0.7-0.3-0.4-0.30.3-0.3-0.50.9-0.7
Total sessions with >9 infusions0.20.31.40.91.20.80.8-0.3-0.4-0.40.30.00.1-0.10.1-0.20.5-0.6
Short access day 1 total inactive lever presses0.30.71.40.31.1-0.5-0.20.20.6-1.0-0.8-0.7-0.90.9-0.8-1.01.2-1.1
Short access day 10 total inactive lever presses0.21.14.4-1.7-2.1-1.2-1.21.40.61.00.30.2-0.30.3-0.40.2-0.91.0
Short access day 1 total infusions0.91.73.3-0.11.2-1.4-0.51.01.1-1.2-1.4-1.3-1.31.3-1.8-1.71.5-1.7
Short access day 10 total infusions0.81.32.8-0.21.2-0.6-0.60.91.0-1.2-0.8-1.1-1.11.1-1.4-1.61.4-1.7
Short access total infusions0.10.10.30.50.60.40.1-0.1-0.2-0.40.20.10.1-0.1-0.1-0.30.3-0.6
Short access day 1 locomotion0.71.24.00.22.00.6-0.00.50.7-1.1-0.9-1.1-1.11.1-0.8-1.51.3-1.6
Short access day 10 total locomotion0.10.51.3-0.30.70.0-0.20.50.7-0.4-1.0-1.1-1.01.0-0.7-0.80.7-0.9
Short access total locomotion0.30.41.80.21.31.00.10.20.2-0.4-0.3-0.6-0.60.6-0.3-0.80.6-0.9
One hour access (0.3 mA shock)0.70.93.01.41.70.70.9-0.9-0.4-1.60.2-0.2-0.30.3-0.1-0.71.3-1.0
Compulsive drug intake0.81.25.4-1.7-2.3-0.7-1.01.20.31.6-0.20.10.3-0.3-0.00.6-1.31.3
One hour access (shock baseline)0.82.18.41.52.90.30.7-0.60.2-2.3-0.3-0.9-1.11.1-0.8-1.52.1-2.0
Social response proportion0.30.41.21.10.81.00.7-0.7-0.4-0.60.10.40.5-0.50.60.40.1-0.4
Social responses0.30.51.3-0.3-0.1-0.3-0.90.30.7-0.2-1.1-0.9-0.80.8-0.8-1.00.4-0.4
Social time0.10.20.70.8-0.00.7-0.1-0.5-0.4-0.40.20.50.4-0.40.50.2-0.10.0
Soleus weight1.85.214.6-3.8-2.6-1.6-3.73.62.52.3-1.9-1.7-1.51.5-1.2-0.9-1.40.6
Bone: stiffness0.81.52.7-0.21.1-0.6-0.40.81.1-0.9-1.5-1.5-1.51.5-1.4-1.51.4-1.7
Tibialis anterior weight0.82.88.4-2.3-2.9-2.7-2.52.51.51.5-0.7-0.8-0.60.6-1.1-0.0-1.01.0
Time to tail flick, vehicle, before self-admin0.40.62.51.60.6-0.60.7-1.2-0.5-1.20.20.00.3-0.3-0.2-0.11.1-0.3
Time to tail flick, vehicle, after self-admin0.40.81.9-1.4-0.6-0.8-1.11.40.80.6-1.3-0.9-0.40.4-1.0-0.90.1-0.1
Time to tail flick, test, before self-admin0.50.61.40.0-0.60.60.7-0.3-0.70.71.20.70.8-0.80.80.8-0.81.1
Time to tail flick, test, after self-admin0.40.41.30.90.91.20.7-1.0-0.7-0.00.2-0.00.6-0.60.3-0.20.2-0.0
Delta time to tail flick, vehicle, before/after SA0.60.62.1-1.4-0.9-0.2-1.21.50.70.9-0.5-0.5-0.20.2-0.5-0.5-0.50.2
Delta time to tail flick, test, before/after SA0.30.41.30.31.10.1-0.1-0.00.3-0.3-1.1-0.8-0.30.3-0.6-0.80.7-0.9
Tibia length1.33.711.50.80.73.42.2-1.7-2.21.11.82.02.1-2.12.61.8-1.31.2
Ambulatory time before self-admin0.30.92.90.81.4-0.30.0-0.40.5-1.7-0.8-0.8-0.90.9-0.6-0.71.5-1.3
Ambulatory time after self-admin0.81.32.4-0.61.61.1-0.80.51.0-0.9-1.2-1.3-1.31.3-0.5-1.41.2-1.4
Bone: tissue strength0.40.40.90.10.5-0.9-0.00.10.4-0.8-0.6-0.6-0.60.6-0.9-0.80.7-0.7
Total heroin consumption0.70.86.80.21.42.60.8-0.6-0.6-0.10.20.30.3-0.31.20.0-0.3-0.0
Bone: trabecular number0.50.92.5-1.6-1.1-1.1-1.21.40.91.1-0.8-0.7-0.70.7-0.8-0.4-0.60.3
Bone: trabecular spacing0.20.30.8-0.10.90.6-0.40.50.5-0.7-0.4-0.5-0.50.50.0-0.40.5-0.8
Bone: trabecular thickness0.60.93.3-1.1-1.8-1.5-0.71.00.21.4-0.2-0.1-0.10.1-0.80.0-0.91.1
Bone: trabecular tissue density0.20.31.3-1.1-0.80.3-0.40.80.20.8-0.2-0.2-0.30.3-0.1-0.3-0.70.5
Water consumed over 24 hours0.20.41.71.30.0-1.10.5-0.5-0.2-1.20.30.10.1-0.1-0.40.10.8-0.4
Number of responses in last shaping day2.83.75.6-0.70.8-2.3-1.51.42.1-1.5-2.1-2.4-2.22.2-2.3-2.02.2-1.9