Hub : Genes

Rasgrp4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Rasgrp4	0.05	0.04	1.1e-08	0.07	0.07	0.06	0.07	4.3e-08	1.3e-08	5.4e-07	3.4e-08
2	PL	intron excision ratio	chr1_84447086_84449273	0.01	0.01	9.2e-03	0	0.01	0.01	0.01	8.7e-02	7.8e-03	3.3e-02	4.8e-02
3	Brain	gene expression	Rasgrp4	0.08	0.05	2.9e-09	0.09	0.1	0.09	0.09	8.1e-09	3.6e-09	8.8e-09	9.6e-09
4	IL	gene expression	Rasgrp4	0.19	0.14	5.0e-04	0.14	0.11	0.14	0.14	2.9e-04	1.6e-03	3.8e-04	2.9e-04
5	PL	alternative TSS	XM_039084022.1	0.03	0.03	4.5e-04	0.03	0.03	0.02	0.03	7.4e-04	5.2e-04	1.4e-03	6.9e-04
6	IL	alternative TSS	XM_039084022.1	0.12	0.09	3.6e-03	0.07	0.05	0.05	0.07	1.1e-02	2.3e-02	2.3e-02	1.1e-02
7	PL	gene expression	Rasgrp4	0.14	0.09	2.6e-13	0.11	0.13	0.12	0.11	1.9e-12	8.0e-14	4.8e-13	3.5e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	0.1	0.1	0.1	-0.3	-0.3	-0.4	-0.2	0.4	-0.2	-0.3
Area under the delay curve	0.1	0.1	0.2	0.4	0.4	0.4	0.3	-0.1	0.4	-0.3
BMI with tail	0.1	0.5	0.7	-0.8	-0.8	-0.8	-0.4	0.6	-0.7	-0.4
BMI without tail	0.2	0.4	0.6	0.5	0.5	0.6	0.8	-0.6	0.7	0.6
Body weight	2.9	12.1	13.5	3.4	3.4	3.4	3.7	-3.4	3.6	3.4
Weight adjusted by age	0.2	0.2	0.2	-0.5	-0.5	-0.5	-0.5	0.4	-0.4	-0.3
Bone surface	0.2	0.4	0.6	0.6	0.6	0.6	0.6	-0.6	0.7	0.6
Bone volume	0.2	0.4	0.5	0.6	0.6	0.6	0.7	-0.6	0.7	0.6
Breakpoint value in progressive ratio session	1.7	1.9	2.8	1.7	1.7	1.6	1.1	-1.4	1.1	1.0
Number of licking bursts	2.4	2.9	3.4	-1.7	-1.7	-1.7	-1.8	1.6	-1.8	-1.5
Context. condit. distance diff. score	0.1	0.1	0.1	-0.3	-0.2	-0.3	-0.3	0.3	-0.3	-0.3
Locomotion velocity, session 1	2.5	2.7	3.0	-1.6	-1.5	-1.6	-1.7	1.7	-1.7	-1.7
Locomotion distance, session 1	0.8	1.1	1.1	1.1	1.0	1.1	1.0	-1.0	1.0	1.0
Locomotion velocity, session 2	0.3	0.4	0.5	-0.7	-0.7	-0.7	-0.4	0.7	-0.5	-0.6
Locomotion distance, session 2	0.5	0.7	1.0	-1.0	-1.0	-1.0	-0.7	0.8	-0.8	-0.6
Locomotion velocity, session 3	0.2	0.3	0.3	-0.6	-0.6	-0.5	-0.5	0.4	-0.6	-0.3
Locomotion distance, session 3	6.0	6.6	7.2	2.5	2.5	2.5	2.6	-2.6	2.6	2.7
Stereotopy head waving bouts, day 3	0.7	0.8	1.0	-1.0	-0.9	-0.9	-1.0	0.8	-1.0	-0.4
Stereotopy head waving duration, day 3	2.8	3.4	3.8	-1.9	-1.9	-1.9	-2.0	1.8	-1.9	-1.6
Locomotion velocity, session 7	0.0	0.0	0.0	0.0	0.0	0.0	0.1	-0.0	0.1	0.0
Locomotion distance, session 7	0.1	0.1	0.2	0.3	0.3	0.3	0.4	-0.3	0.3	0.3
Stereotopy head waving bouts, day 7	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.3	0.2	-0.2	0.0
Stereotopy head waving duration, day 7	1.0	1.2	1.5	-1.2	-1.2	-1.2	-1.1	1.1	-1.1	-0.9
Locomotion velocity, session 8	3.4	4.1	4.6	-2.1	-2.1	-2.1	-1.9	2.0	-2.1	-1.8
Locomotion distance, session 8	0.3	0.5	0.6	-0.8	-0.8	-0.7	-0.6	0.7	-0.7	-0.6
Degree of sensitization distance	3.4	3.4	4.1	-1.8	-1.8	-1.8	-1.8	1.9	-1.8	-2.0
Degree of sensitization stereotypy	0.0	0.0	0.0	-0.2	-0.2	-0.1	-0.1	0.0	-0.1	0.2
Conditioned locomotion	0.3	0.3	1.0	0.4	0.4	0.4	0.4	-0.7	0.5	1.0
Cocaine response after cond. corrected	0.4	0.4	0.6	0.6	0.6	0.6	0.7	-0.7	0.6	0.8
Cocaine response after cond. not corrected	0.6	0.7	1.1	0.6	0.7	0.7	1.0	-0.9	0.8	1.1
Cocaine response before conditioning	1.5	1.8	2.6	1.1	1.1	1.2	1.5	-1.4	1.2	1.6
Saline control response	0.4	0.5	0.6	0.7	0.7	0.7	0.7	-0.8	0.7	0.7
Bone: connectivity density	0.5	0.8	1.0	-0.9	-0.9	-0.9	-0.8	0.9	-0.7	-1.0
Bone: cortical apparent density	2.3	3.0	3.2	-1.8	-1.8	-1.8	-1.7	1.7	-1.8	-1.6
Bone: cortical area	2.2	3.3	3.5	1.8	1.8	1.8	1.7	-1.8	1.8	1.9
Bone: cortical porosity	0.8	0.9	1.3	-1.2	-1.1	-1.1	-0.7	0.9	-0.9	-0.5
Bone: cortical porosity	0.9	1.0	1.5	-1.2	-1.2	-1.2	-0.8	0.9	-1.0	-0.6
Bone: cortical thickness	0.9	1.4	1.8	1.2	1.2	1.2	1.1	-1.3	1.1	1.3
Bone: cortical thickness	0.1	0.1	0.3	-0.5	-0.5	-0.5	-0.1	0.3	-0.4	0.0
Bone: cortical tissue density	2.7	3.5	3.8	-1.9	-2.0	-1.9	-1.8	1.9	-1.9	-1.7
Condit. Reinf. active minus inactive responses	0.3	0.3	0.5	-0.6	-0.5	-0.5	-0.6	0.5	-0.7	-0.5
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.6	-0.5	-0.4	-0.4	-0.8	0.4	-0.6	-0.4
Condit. Reinf. active responses	1.1	1.4	1.7	-1.3	-1.3	-1.3	-1.0	1.2	-1.2	-1.0
Condit. Reinf. inactive responses	0.7	0.8	1.2	-1.0	-1.1	-1.0	-0.5	0.9	-0.8	-0.8
Incentive salience index mean	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.0	0.1	-0.2	-0.0
Condit. Reinf. lever presses	0.1	0.2	0.4	0.3	0.3	0.3	0.7	-0.4	0.4	0.4
Condit. Reinf. active minus inactive responses	4.2	5.2	5.5	2.3	2.3	2.3	2.2	-2.3	2.2	2.3
Condit. Reinf. active-inactive response ratio	2.6	2.7	3.9	1.5	1.5	1.6	1.6	-1.8	1.5	2.0
Condit. Reinf. active responses	4.9	6.8	7.2	2.7	2.7	2.7	2.6	-2.6	2.5	2.6
Condit. Reinf. inactive responses	1.7	2.1	2.5	1.6	1.6	1.5	1.5	-1.3	1.5	1.1
Condit. Reinf. lever presses	7.5	10.2	11.5	3.4	3.4	3.3	3.3	-3.1	3.0	2.8
Condit. Reinf. lever reinforcers received	5.8	8.2	8.4	2.9	2.9	2.9	2.8	-2.9	2.8	2.8
Conditioned reinforcement - actives	0.3	0.3	0.5	0.4	0.4	0.4	0.5	-0.5	0.7	0.6
Conditioned reinforcement - inactives	2.1	2.4	2.5	1.6	1.6	1.6	1.5	-1.6	1.5	1.6
Conditioned locomotion	1.2	1.4	2.0	-1.4	-1.4	-1.3	-1.1	1.2	-0.9	-0.9
Patch foraging indifference point 0 sec	0.3	0.4	0.8	0.6	0.6	0.6	0.9	-0.6	0.6	0.7
Patch foraging indifference point AUC	0.4	0.4	0.6	-0.7	-0.8	-0.7	-0.7	0.6	-0.5	-0.5
Delay disc. indifference point, 0s delay	0.7	0.7	1.3	0.9	0.9	0.8	1.2	-0.7	1.0	0.5
Delay disc. indifference point, 16s delay	1.6	1.6	2.0	1.4	1.4	1.3	1.4	-1.1	1.4	0.7
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	0.4	0.4	0.3	-0.1	0.1	0.1	-0.5
Delay disc. indifference point, 24s delay	1.5	1.5	1.8	1.3	1.3	1.3	1.3	-1.1	1.3	0.9
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.3	0.3	0.3	0.4	-0.2	0.3	0.1
Delay disc. indifference point, 8s delay	0.7	0.7	1.5	-0.6	-0.6	-0.7	-0.9	0.9	-0.8	-1.2
Indifference point function ln k	0.4	0.6	0.7	0.8	0.8	0.8	0.8	-0.7	0.7	0.6
Indifference point function log k	0.4	0.6	0.7	0.8	0.8	0.8	0.8	-0.7	0.7	0.6
Patch foraging total patch changes 0 sec	0.4	0.6	0.9	0.7	0.7	0.7	1.0	-0.7	0.7	0.7
Patch foraging total patch changes 12 sec	0.3	0.4	0.9	0.5	0.5	0.5	0.9	-0.6	0.7	0.7
Patch foraging total patch changes 18 sec	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.2	0.3	-0.2	-0.2
Patch foraging total patch changes 24 sec	0.7	0.9	1.1	0.9	0.9	0.9	1.1	-0.9	1.0	0.8
Patch foraging total patch changes 6 sec	0.1	0.1	0.4	0.2	0.2	0.2	0.6	-0.3	0.4	0.4
Patch foraging time to switch 0 sec	1.0	1.6	2.0	-1.2	-1.2	-1.3	-1.1	1.4	-1.2	-1.4
Patch foraging water rate 0 sec	0.5	0.8	1.0	-0.9	-0.9	-0.9	-1.0	0.8	-0.9	-0.7
Patch foraging water rate 12 sec	0.8	1.2	1.4	1.2	1.2	1.2	0.9	-1.1	0.9	1.1
Patch foraging water rate 18 sec	0.6	0.9	1.3	-0.7	-0.7	-0.7	-1.1	0.9	-1.1	-1.1
Patch foraging water rate 24 sec	0.3	0.4	0.6	0.7	0.7	0.7	0.3	-0.7	0.3	0.8
Patch foraging water rate 6 sec	0.1	0.1	0.2	0.5	0.5	0.4	-0.1	-0.3	0.2	0.2
Seeking ratio, delayed vs. immediate footshock	1.3	1.5	1.8	1.3	1.3	1.3	1.2	-1.3	0.8	1.2
Distance traveled before self-admin	1.9	2.0	2.3	1.4	1.4	1.4	1.4	-1.5	1.2	1.5
Distance traveled after self-admin	5.6	6.3	6.8	2.6	2.6	2.6	2.3	-2.5	2.6	2.3
Extensor digitorum longus weight	0.2	0.8	0.9	-0.9	-0.9	-0.9	-0.7	0.9	-0.9	-0.9
Bone: elastic displacement	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.1	0.2	-0.2	-0.3
Bone: elastic work	2.3	2.9	3.1	1.7	1.7	1.7	1.8	-1.7	1.6	1.8
Bone: endosteal estimation	1.3	2.8	3.0	1.7	1.7	1.7	1.7	-1.6	1.7	1.5
Bone: endosteal perimeter	1.2	2.5	2.8	1.7	1.7	1.6	1.6	-1.5	1.7	1.3
Epididymis fat weight	0.0	0.0	0.0	-0.2	-0.2	-0.1	0.1	0.1	-0.0	-0.1
Delta time in closed arm before/after self-admin	0.8	0.7	1.2	0.8	0.8	0.8	1.1	-0.7	1.1	0.6
Delta time in open arm before/after self-admin	0.2	0.2	0.4	-0.3	-0.4	-0.3	-0.6	0.2	-0.6	0.0
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	0.4	0.4	0.4	0.1	-0.3	0.1	0.2
Delay discount exponential model param	0.1	0.1	0.2	-0.5	-0.5	-0.4	-0.3	0.1	-0.4	0.2
Extinction: sum of active levers before priming	1.4	1.4	1.6	1.2	1.2	1.2	1.2	-1.1	1.3	1.0
Active lever presses in extinction session 6	0.5	0.5	1.0	0.8	0.8	0.7	0.7	-0.6	1.0	0.3
Bone: final force	1.8	2.8	3.0	1.7	1.7	1.7	1.7	-1.7	1.7	1.7
Bone: final moment	2.6	4.2	4.6	2.0	2.0	2.0	2.0	-2.1	2.0	2.1
Food consumed during 24 hour testing period	0.3	0.4	0.5	0.7	0.7	0.7	0.6	-0.6	0.6	0.5
Glucose	0.3	0.4	0.5	-0.7	-0.7	-0.7	-0.4	0.7	-0.5	-0.7
Heart weight	0.7	0.9	1.3	0.9	0.9	0.9	0.9	-1.0	0.9	1.1
Delay discount hyperbolic model param	0.1	0.1	0.1	-0.4	-0.4	-0.3	-0.1	0.0	-0.2	0.3
Intermittent access intake day 1-15 change	1.7	1.6	2.4	1.2	1.2	1.2	1.5	-1.1	1.5	1.0
Intermittent access intake escalation	1.2	1.2	1.6	1.1	1.1	1.1	1.3	-1.0	1.2	0.9
Intermittent access intake escalation 2	3.4	3.4	4.0	1.8	1.8	1.8	2.0	-1.8	1.9	1.8
Intermitt. access day 1 inactive lever presses	0.5	0.5	0.7	0.8	0.8	0.8	0.8	-0.6	0.7	0.3
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.4	0.6	0.6	0.6	0.5	-0.4	0.6	0.2
Intermitt. access escalation Index	0.1	0.1	0.1	0.3	0.3	0.3	0.0	-0.4	-0.0	0.3
Intermittent access day 1 total infusions	0.1	0.1	0.3	-0.4	-0.3	-0.3	-0.5	0.1	-0.5	0.2
Intermittent access day 15 total infusions	0.7	0.8	1.1	0.9	0.9	0.9	0.9	-1.0	0.8	1.1
Intermittent access terminal intake (last 3 days)	1.3	1.5	1.9	1.1	1.1	1.2	1.2	-1.3	1.2	1.4
Intermittent access total infusions	0.4	0.4	0.8	0.6	0.6	0.6	0.5	-0.7	0.6	0.9
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.3	-0.3	-0.2	-0.2	0.0	-0.2	0.2
Intermittent access day 15 total locomotion	0.0	0.0	0.0	-0.2	-0.2	-0.2	0.2	0.2	0.1	-0.1
Intermittent access total locomotion	0.4	0.4	0.7	-0.8	-0.8	-0.8	-0.5	0.7	-0.5	-0.5
Intermittent access standard deviation	5.2	5.5	6.4	2.5	2.5	2.5	2.2	-2.3	2.3	2.1
Left kidney weight	2.8	7.8	9.6	2.6	2.6	2.6	2.9	-2.9	2.8	3.1
Right kidney weight	4.3	12.1	12.7	3.5	3.4	3.5	3.6	-3.5	3.5	3.5
Cocaine induced anxiety	0.0	0.0	0.0	0.2	0.2	0.1	-0.0	0.0	0.1	-0.2
Post-drug Anxiety	0.3	0.3	0.8	-0.5	-0.5	-0.5	-0.5	0.7	-0.3	-0.9
Baseline Anxiety	0.2	0.2	0.3	-0.5	-0.5	-0.5	-0.4	0.3	-0.4	-0.1
Tail length	5.5	16.8	18.0	4.2	4.2	4.2	4.0	-4.0	4.2	3.7
Length with tail	8.2	30.0	31.9	5.6	5.6	5.6	5.5	-5.4	5.6	5.0
Length without tail	3.7	8.1	8.9	3.0	3.0	2.9	2.8	-2.9	2.8	2.7
Times rat made contact with spout	0.4	0.5	0.7	-0.8	-0.8	-0.8	-0.6	0.6	-0.7	-0.4
Lifetime Intake	0.0	0.0	0.1	-0.0	0.0	0.1	-0.0	-0.2	0.0	0.4
Liver weight, left	0.1	0.1	0.3	-0.5	-0.5	-0.5	0.2	0.3	-0.2	-0.0
Liver weight, right	0.0	0.0	0.1	0.0	0.0	0.0	0.3	-0.1	0.1	0.2
Locomotor activity	0.4	0.7	0.9	-0.9	-0.9	-0.9	-0.6	0.8	-0.8	-0.6
Locomotor testing distance	0.9	1.5	1.7	-1.3	-1.3	-1.3	-1.2	1.2	-1.3	-1.1
Locomotor testing rearing	1.4	2.2	2.6	-1.6	-1.6	-1.6	-1.3	1.4	-1.6	-1.2
Locomotion in novel chamber	0.3	0.4	0.6	-0.6	-0.6	-0.6	-0.5	0.7	-0.6	-0.8
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	0.4	0.4	0.3	-0.4	-0.1	-0.1	-0.1
Fecal boli incidents, locomotor time 1	3.0	3.3	4.3	-1.8	-1.8	-1.8	-1.7	1.9	-1.8	-2.1
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	0.4	0.4	0.4	0.3	-0.4	0.3	0.5
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	0.1	-0.1	-0.1
Bouts of movement, locomotor time 1	0.4	0.4	0.8	0.9	0.9	0.8	0.3	-0.5	0.6	0.1
Total resting periods, locomotor time 1	0.3	0.3	0.6	0.8	0.8	0.7	0.2	-0.4	0.4	-0.1
Rest time, locomotor task time 1	0.1	0.1	0.1	-0.2	-0.2	-0.2	-0.2	0.2	-0.2	-0.3
Distance moved, locomotor task time 1	0.1	0.1	0.3	0.2	0.2	0.2	0.5	-0.3	0.4	0.6
Vertical activity count, locomotor time 1	1.2	1.2	1.5	1.0	1.0	1.1	1.1	-1.1	1.1	1.2
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	0.0	-0.0	0.0	0.3	-0.1	0.1	0.2
Bouts of movement, locomotor time 2	0.1	0.2	0.6	-0.2	-0.2	-0.3	0.0	0.5	-0.1	-0.8
Total resting periods, locomotor time 2	0.2	0.2	0.6	-0.3	-0.3	-0.3	-0.1	0.5	-0.2	-0.8
Rest time, locomotor task time 2	0.2	0.2	0.4	0.4	0.4	0.4	0.0	-0.5	0.2	0.7
Distance moved, locomotor task time 2	0.1	0.1	0.1	-0.3	-0.3	-0.3	0.2	0.2	-0.0	-0.1
Vertical activity count, locomotor time 2	0.2	0.2	0.5	0.5	0.5	0.4	0.7	-0.4	0.6	0.3
Light reinforcement 1	0.1	0.2	0.3	-0.5	-0.6	-0.6	-0.1	0.5	-0.3	-0.5
Light reinforcement 2	7.0	9.3	9.9	-3.0	-3.0	-3.0	-3.1	3.1	-3.0	-3.2
Bone: marrow area	1.3	2.9	3.1	1.8	1.8	1.7	1.8	-1.7	1.8	1.5
Bone: maximum diameter	1.5	2.8	3.1	1.6	1.6	1.6	1.8	-1.6	1.7	1.6
Bone: maximum force	3.0	5.1	5.2	2.3	2.3	2.3	2.2	-2.3	2.2	2.2
Bone: maximum moment	3.9	6.7	6.9	2.6	2.6	2.6	2.6	-2.6	2.5	2.6
Mean time between licks in bursts	0.1	0.2	0.3	0.4	0.4	0.4	0.6	-0.4	0.4	0.5
Mean num. licks in bursts	0.9	1.1	1.5	1.0	1.0	1.0	1.2	-1.0	1.1	1.0
Cd content in liver	0.4	0.4	0.7	-0.5	-0.5	-0.5	-0.8	0.6	-0.7	-0.7
Co content in liver	2.0	2.3	2.5	-1.5	-1.5	-1.5	-1.5	1.5	-1.6	-1.5
Cu content in liver	1.2	1.4	1.5	1.2	1.1	1.2	1.2	-1.2	1.1	1.2
Fe content in liver	0.3	0.3	0.6	-0.5	-0.5	-0.5	-0.5	0.7	-0.5	-0.8
K content in liver	0.6	0.6	0.9	0.7	0.6	0.7	0.9	-0.8	0.8	0.9
Mg content in liver	0.0	0.0	0.1	-0.0	-0.0	-0.0	0.2	-0.2	0.1	0.4
Mn content in liver	0.3	0.4	1.3	0.2	0.2	0.3	0.6	-0.7	0.4	1.1
Na content in liver	5.7	6.0	7.0	2.3	2.3	2.3	2.6	-2.4	2.5	2.5
Rb content in liver	0.0	0.0	0.1	0.1	0.1	0.0	0.3	-0.0	0.1	-0.0
Se content in liver	3.8	4.7	5.9	-2.4	-2.4	-2.3	-2.1	2.0	-2.1	-1.6
Sr content in liver	0.9	0.8	1.0	-0.9	-0.9	-0.9	-1.0	0.8	-0.9	-0.7
Zn content in liver	0.3	0.4	0.5	-0.6	-0.6	-0.6	-0.7	0.6	-0.6	-0.6
Bone: minimum diameter	5.7	10.7	11.0	3.3	3.3	3.3	3.2	-3.3	3.2	3.3
Time in familiar zone, hab. session 1	0.3	0.3	0.5	0.5	0.5	0.5	0.7	-0.5	0.6	0.5
Time in novel zone, hab. session 1	0.2	0.2	0.3	-0.4	-0.4	-0.4	-0.5	0.3	-0.5	-0.2
Total zone transitions, hab. session 1	0.5	0.8	1.3	0.8	0.7	0.8	1.1	-0.8	0.9	0.9
Total locomotion distance, hab. session 1	3.2	4.6	5.3	2.2	2.2	2.2	2.3	-2.1	2.2	1.9
Locomotion velocity, hab. session 1	1.4	2.0	2.4	1.5	1.4	1.4	1.5	-1.4	1.4	1.2
Time in familiar zone, hab. session 2	0.5	0.5	0.8	0.9	0.9	0.9	0.5	-0.6	0.7	0.4
Time in novel zone, hab. session 2	0.6	0.6	0.8	-0.9	-0.9	-0.9	-0.6	0.8	-0.8	-0.7
Total zone transitions, hab. session 2	0.1	0.1	0.3	-0.5	-0.5	-0.5	-0.1	0.2	-0.4	0.1
Total locomotion distance, hab. session 2	0.4	0.5	0.7	0.6	0.6	0.7	0.8	-0.7	0.6	0.8
Locomotion velocity, hab. session 2	0.3	0.4	0.7	0.5	0.5	0.5	0.7	-0.7	0.5	0.8
Novel to familiar place preference ratio	1.2	1.2	1.4	1.1	1.0	1.1	1.1	-1.1	1.2	1.1
Novelty place preference	1.1	1.1	1.3	1.0	1.0	1.0	1.1	-1.1	1.1	1.1
Time in novel zone, NPP test	0.6	0.6	0.8	0.8	0.7	0.8	0.8	-0.8	0.9	0.8
Total zone transitions, NPP test	0.1	0.2	0.2	-0.4	-0.5	-0.4	-0.2	0.5	-0.4	-0.5
Total locomotion distance, NPP test	1.8	2.5	2.8	1.7	1.7	1.7	1.6	-1.5	1.6	1.3
Locomotion velocity, NPP test	2.3	3.2	3.6	1.9	1.9	1.9	1.8	-1.7	1.8	1.6
Intraocular pressure	0.0	0.1	0.2	-0.1	-0.1	-0.1	-0.4	0.2	-0.2	-0.4
Delta distance traveled before/after self-admin	0.7	0.8	1.2	1.0	1.0	1.0	0.7	-0.7	1.1	0.4
Delta ambulatory time before/after self-admin	1.2	1.4	1.7	1.3	1.3	1.2	1.0	-1.1	1.3	1.0
Parametrial fat weight	0.6	1.2	1.5	-1.2	-1.2	-1.2	-1.0	1.1	-1.1	-0.9
Pavlov. Cond. lever latency	0.1	0.2	0.4	-0.2	-0.2	-0.2	-0.7	0.4	-0.4	-0.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.3	0.4	-0.5	-0.4
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.0	-0.0	-0.0	0.1	-0.0	-0.0	0.0
Pavlov. Cond. index score	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.3	-0.0	-0.0	0.2
Pavlov. Cond. latency score	0.0	0.1	0.2	0.0	0.0	0.1	0.4	-0.2	0.2	0.3
Pavlov. Cond. lever contacts	0.8	0.9	1.7	0.8	0.8	0.8	1.3	-0.9	1.0	1.0
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	0.3	0.3	0.3	0.2	-0.2	0.4	0.2
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.3	-0.5	-0.5	-0.5	-0.5	0.4	-0.4	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.0	0.0	0.1	0.5	-0.2	0.1	0.4
Pavlov. Cond. response bias	0.1	0.1	0.3	0.2	0.2	0.2	0.5	-0.3	0.2	0.4
Pavlov. Cond. lever latency	3.5	4.7	5.4	-2.3	-2.3	-2.3	-2.1	2.1	-2.1	-1.9
Pavlov. Cond. magazine entry latency	2.0	2.3	2.6	1.6	1.6	1.6	1.5	-1.4	1.5	1.2
Pavlov. Cond. change in total contacts	6.7	9.2	10.6	3.3	3.3	3.2	2.9	-3.0	2.9	2.7
Pavlov. Cond. index score	3.2	4.2	4.9	2.2	2.2	2.2	2.1	-1.9	2.0	1.6
Pavlov. Cond. latency score	3.1	3.8	4.5	2.1	2.1	2.1	2.0	-1.9	1.9	1.6
Pavlov. Cond. lever contacts	3.3	4.5	5.3	2.3	2.3	2.3	2.1	-2.1	2.0	1.8
Pavlov. Cond. magazine entry number	1.3	1.6	2.1	-1.5	-1.5	-1.4	-1.3	1.2	-1.3	-0.8
Pavlov. Cond. intertrial magazine entries	1.0	1.3	1.6	-1.3	-1.3	-1.2	-1.2	1.1	-1.2	-0.8
Pavlov. Cond. lever-magazine prob. diff.	3.7	4.7	5.3	2.3	2.3	2.3	2.2	-2.1	2.1	1.8
Pavlov. Cond. response bias	3.8	5.1	5.9	2.4	2.4	2.4	2.2	-2.2	2.2	1.9
Time in closed arm before self-admin	0.2	0.2	0.6	-0.3	-0.3	-0.3	-0.6	0.2	-0.8	-0.1
Time in closed arm after self-admin	0.2	0.2	0.4	0.5	0.6	0.5	0.6	-0.4	0.3	0.2
Time in open arm before self-admin	1.4	1.6	2.0	1.2	1.2	1.2	1.3	-1.2	1.4	1.1
Time in open arm after self-admin	0.8	0.9	1.6	0.8	0.8	0.8	0.8	-1.0	0.9	1.3
Bone: periosteal estimation	2.2	4.5	4.6	2.2	2.1	2.1	2.1	-2.1	2.1	2.1
Bone: periosteal perimeter	1.9	3.2	3.5	1.9	1.9	1.8	1.8	-1.8	1.8	1.6
Bone: post-yield work	0.8	1.1	1.4	1.2	1.2	1.1	0.9	-1.0	1.0	0.8
Progressive ratio test 1 active lever presses	1.4	1.5	2.2	1.1	1.2	1.2	1.1	-1.3	0.9	1.5
Progressive ratio test 1 breakpoint	1.9	2.0	2.7	1.4	1.4	1.4	1.4	-1.5	1.1	1.7
Progressive ratio test 1 inactive lever presses	0.3	0.4	0.5	0.7	0.7	0.7	0.4	-0.6	0.6	0.4
Progressive ratio test 2 active lever presses	0.6	0.6	0.7	0.8	0.8	0.8	0.8	-0.8	0.8	0.8
Progressive ratio test 2 breakpoint	0.6	0.6	0.7	0.8	0.8	0.8	0.8	-0.8	0.8	0.8
Progressive ratio test 2 inactive lever presses	2.9	3.3	4.0	2.0	2.0	2.0	1.7	-1.8	1.7	1.5
Incentive Sensitization - Responses	0.0	0.0	0.0	0.1	0.1	0.1	0.2	0.0	0.2	-0.2
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.0	0.2	0.1	-0.4
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.1	0.1	0.1	0.1	-0.1	0.2	0.2
Progressive ratio	0.3	0.4	0.7	-0.6	-0.6	-0.6	-0.6	0.7	-0.3	-0.9
Food seeking constrained by brief footshock	3.1	3.8	4.3	2.1	2.1	2.1	1.8	-2.0	1.9	1.8
Seeking ratio, punishment vs. effort	1.8	2.2	2.7	1.5	1.6	1.6	1.3	-1.6	1.1	1.6
Retroperitoneal fat weight	1.1	3.5	4.5	-2.1	-2.1	-2.1	-1.5	1.8	-1.8	-1.5
Reaction time number correct	0.0	0.0	0.2	-0.1	-0.0	-0.0	0.1	-0.2	0.0	0.5
Reaction time mean minus median	0.2	0.2	0.3	0.5	0.5	0.5	0.5	-0.5	0.4	0.5
Reaction time mean minus median AUC	0.3	0.4	0.5	0.6	0.6	0.6	0.7	-0.6	0.5	0.7
Reaction time num false alarms	0.9	1.3	1.6	-1.2	-1.2	-1.2	-1.0	1.1	-1.0	-1.0
Reaction time num false alarms AUC	1.3	1.8	2.2	-1.5	-1.5	-1.4	-1.2	1.3	-1.3	-1.2
Reaction time trials correct on left	0.0	0.0	0.2	-0.1	-0.0	-0.0	0.1	-0.2	0.0	0.5
Reaction time trials on left	0.0	0.0	0.2	-0.1	-0.1	-0.0	0.1	-0.2	-0.0	0.5
Reaction time mean	0.1	0.1	0.1	-0.3	-0.3	-0.2	-0.3	0.2	-0.4	-0.3
Reaction time mean AUC	0.2	0.2	0.3	-0.5	-0.5	-0.5	-0.4	0.4	-0.6	-0.4
Median of all reaction times	0.2	0.3	0.3	-0.5	-0.5	-0.5	-0.5	0.5	-0.6	-0.5
Reaction time omissions	0.2	0.3	0.4	-0.6	-0.5	-0.5	-0.5	0.5	-0.6	-0.4
Reaction time false alarm rate	1.1	1.5	1.8	-1.2	-1.2	-1.2	-1.1	1.3	-1.1	-1.4
Reaction time premature initiation rate	0.0	0.0	0.0	0.2	0.2	0.1	-0.0	-0.0	0.1	-0.1
Reaction time premature initiations	0.0	0.0	0.0	0.1	0.1	0.1	-0.0	-0.1	-0.0	0.1
Std. dev. reaction times	0.1	0.1	0.1	0.3	0.3	0.3	0.2	-0.4	0.2	0.4
Reaction time trials completed	0.0	0.0	0.2	-0.1	-0.1	-0.0	0.1	-0.2	-0.0	0.5
Reaction time trials AUC	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.1	-0.1	-0.2	0.4
Run reversals in cocaine runway, females	0.3	0.3	0.4	-0.5	-0.5	-0.5	-0.5	0.6	-0.6	-0.7
Run reversals in cocaine runway, males	1.3	1.2	2.0	-1.1	-1.1	-1.1	-1.2	1.0	-1.4	-0.8
Latency to leave start box in cocaine runway	0.0	0.0	0.1	-0.2	-0.2	-0.3	-0.2	0.2	0.1	-0.2
Latency to leave start box in cocaine runway, F	0.4	0.5	0.6	-0.7	-0.7	-0.7	-0.8	0.7	-0.5	-0.6
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.3	0.3	0.3	0.2	-0.2	0.3	0.2
Std. dev. time between licks in bursts	0.8	0.9	1.1	1.0	1.0	1.0	1.1	-0.9	1.1	0.8
Total sessions with >9 infusions	0.1	0.1	0.3	-0.6	-0.5	-0.4	-0.2	0.1	-0.1	0.3
Short access day 1 total inactive lever presses	0.5	0.5	0.7	0.9	0.9	0.8	0.7	-0.7	0.8	0.5
Short access day 10 total inactive lever presses	0.3	0.3	0.5	0.7	0.7	0.7	0.5	-0.4	0.6	0.1
Short access day 1 total infusions	0.2	0.2	0.6	0.4	0.4	0.4	0.4	-0.6	0.2	0.8
Short access day 10 total infusions	0.2	0.2	0.4	-0.5	-0.5	-0.5	-0.6	0.3	-0.5	-0.1
Short access total infusions	0.2	0.3	0.4	-0.7	-0.6	-0.6	-0.5	0.4	-0.5	-0.1
Short access day 1 locomotion	1.4	1.5	2.2	-1.5	-1.5	-1.4	-0.9	1.3	-0.9	-1.0
Short access day 10 total locomotion	0.4	0.5	0.9	0.5	0.5	0.5	0.9	-0.6	1.0	0.7
Short access total locomotion	0.2	0.2	0.5	-0.7	-0.7	-0.6	-0.1	0.4	-0.1	-0.1
One hour access (0.3 mA shock)	1.4	1.6	1.8	1.3	1.3	1.3	1.3	-1.2	1.3	1.1
Compulsive drug intake	0.3	0.3	0.4	0.7	0.7	0.6	0.4	-0.6	0.5	0.5
One hour access (shock baseline)	0.2	0.2	0.3	0.4	0.4	0.4	0.5	-0.4	0.5	0.4
Social response proportion	4.5	4.9	5.4	2.2	2.2	2.3	2.1	-2.3	2.0	2.3
Social responses	0.1	0.1	0.2	0.4	0.4	0.4	0.4	-0.3	0.3	0.2
Social time	0.5	0.7	1.1	1.1	1.1	1.0	0.6	-0.8	0.8	0.4
Soleus weight	0.8	2.3	3.0	-1.4	-1.4	-1.5	-1.4	1.6	-1.5	-1.7
Bone: stiffness	1.5	2.3	2.5	1.6	1.6	1.6	1.4	-1.5	1.5	1.5
Tibialis anterior weight	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.3	-0.0	0.0	0.1
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	-0.1	-0.1	-0.1	0.7	-0.2	0.6	0.6
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.4	0.6	0.6	0.6	0.2	-0.5	0.1	0.3
Time to tail flick, test, before self-admin	0.1	0.1	0.3	-0.1	-0.1	-0.1	0.5	-0.1	0.3	0.4
Time to tail flick, test, after self-admin	0.0	0.0	0.0	-0.2	-0.1	-0.1	0.2	-0.0	0.1	0.2
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	0.5	0.5	0.5	-0.0	-0.4	-0.1	0.1
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.3	0.1	-0.2	0.0
Tibia length	2.1	5.9	6.5	2.4	2.4	2.4	2.5	-2.4	2.4	2.4
Ambulatory time before self-admin	1.1	1.1	1.3	1.1	1.1	1.1	1.0	-1.1	0.9	1.1
Ambulatory time after self-admin	6.0	6.5	7.6	2.7	2.7	2.7	2.2	-2.6	2.5	2.3
Bone: tissue strength	4.5	4.3	4.6	2.1	2.1	2.2	1.9	-2.1	2.1	2.0
Total heroin consumption	1.6	1.8	2.0	1.4	1.4	1.4	1.2	-1.4	1.3	1.3
Bone: trabecular number	0.1	0.2	0.3	0.3	0.3	0.3	0.6	-0.3	0.5	0.3
Bone: trabecular spacing	1.7	2.3	2.4	1.5	1.5	1.5	1.4	-1.5	1.5	1.5
Bone: trabecular thickness	0.2	0.3	0.4	-0.6	-0.6	-0.6	-0.3	0.5	-0.5	-0.3
Bone: trabecular tissue density	2.6	3.7	3.9	-2.0	-2.0	-2.0	-1.9	1.9	-1.9	-1.8
Water consumed over 24 hours	0.7	0.9	1.3	0.8	0.8	0.8	1.0	-1.0	0.9	1.2
Number of responses in last shaping day	2.3	2.4	3.0	1.5	1.5	1.5	1.5	-1.6	1.4	1.7