Hub : Genes

Ralbp1l4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg gene expression Ralbp1l4 0.22 0.14 6.0e-05 0.1 0.11 0.06 0.11 1.3e-03 7.7e-04 9.1e-03 7.4e-04
2 Brain gene expression Ralbp1l4 0.3 0.16 0.0e+00 0.29 0.29 0.29 0.29 1.9e-27 3.3e-27 1.5e-27 1.4e-27
3 Adipose gene expression Ralbp1l4 0.29 0.14 0.0e+00 0.26 0.27 0.27 0.27 4.8e-29 5.8e-30 8.8e-30 3.7e-30
4 Liver gene expression Ralbp1l4 0.12 0.08 1.4e-14 0.11 0.11 0.11 0.11 4.2e-12 4.6e-12 2.5e-12 4.9e-12
5 PL gene expression Ralbp1l4 0.1 0.11 3.4e-09 0.07 0.08 0.07 0.07 3.1e-08 1.0e-08 2.9e-08 3.3e-08
6 IL gene expression Ralbp1l4 0.18 0.11 3.5e-03 0 0.03 0.01 0.02 3.1e-01 5.3e-02 1.7e-01 8.9e-02
7 Eye gene expression Ralbp1l4 0.21 0.08 3.0e-03 0.19 0.16 0.14 0.19 7.2e-04 1.9e-03 4.3e-03 7.3e-04
8 pVTA gene expression Ralbp1l4 0.09 0.06 4.1e-08 0.09 0.1 0.1 0.09 1.7e-07 3.5e-08 4.2e-08 9.1e-08
9 pVTA intron excision ratio chr7_504353_505970 0.04 0.03 1.6e-03 0.01 0.03 0.02 0.02 5.0e-02 2.6e-03 4.7e-03 9.7e-03
10 NAcc gene expression Ralbp1l4 0.03 0.02 1.6e-04 0 0.01 0.01 0.01 8.2e-02 4.4e-03 6.0e-03 1.9e-02
11 NAcc intron excision ratio chr7_600260_601040 0.02 0.02 1.2e-03 0.01 0.02 0.01 0.02 1.4e-02 5.4e-04 5.4e-03 9.8e-04
12 OFC gene expression Ralbp1l4 0.1 0.05 8.2e-03 0.01 0.08 0.08 0.06 1.4e-01 6.3e-03 6.6e-03 1.6e-02
13 BLA gene expression Ralbp1l4 0.16 0.11 1.0e-04 0.08 0.08 0.06 0.07 7.7e-05 5.7e-05 3.5e-04 1.1e-04
14 IC gene expression Ralbp1l4 0.11 0.08 1.3e-04 0.07 0.08 0.1 0.07 4.7e-04 2.9e-04 4.0e-05 8.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.22.05.5-0.4-0.6-0.5-0.9-1.0-1.11.1-1.61.7-1.71.8-2.1-2.4-1.4
Area under the delay curve0.00.00.1-0.3-0.1-0.1-0.2-0.1-0.1-0.0-0.10.1-0.10.1-0.1-0.20.1
BMI with tail5.519.028.75.45.25.25.14.94.75.14.0-3.93.8-3.83.12.13.4
BMI without tail1.33.95.92.42.32.42.32.22.12.11.9-1.81.8-1.81.51.11.4
Body weight0.83.74.72.12.12.12.22.12.11.52.0-1.91.9-1.91.71.51.6
Weight adjusted by age0.00.00.1-0.2-0.1-0.2-0.0-0.00.0-0.30.1-0.10.1-0.10.20.30.1
Bone surface2.64.811.8-1.3-1.2-1.0-1.8-1.7-1.91.0-2.52.6-2.72.7-3.1-3.4-1.8
Bone volume2.64.612.1-1.1-1.1-0.9-1.6-1.6-1.81.2-2.42.5-2.62.7-3.1-3.5-1.8
Breakpoint value in progressive ratio session0.50.60.9-0.7-0.8-0.9-0.9-0.9-0.9-1.0-0.70.7-0.70.7-0.5-0.3-0.8
Number of licking bursts3.04.95.72.32.32.22.22.32.41.42.4-2.42.4-2.42.32.12.1
Context. condit. distance diff. score0.40.50.60.70.70.70.80.70.70.40.7-0.70.7-0.70.70.60.7
Locomotion velocity, session 10.60.61.7-0.4-0.4-0.3-0.3-0.5-0.60.7-0.90.9-1.01.0-1.1-1.3-0.8
Locomotion distance, session 11.31.63.5-0.9-0.8-0.8-1.1-1.1-1.20.1-1.51.5-1.51.6-1.7-1.9-0.9
Locomotion velocity, session 23.54.05.7-1.8-1.8-1.8-1.8-2.0-2.0-0.5-2.32.3-2.32.3-2.4-2.4-1.7
Locomotion distance, session 25.57.69.1-2.7-2.7-2.7-2.8-2.8-2.9-1.4-3.03.0-3.03.0-3.0-2.8-2.3
Locomotion velocity, session 32.52.95.0-2.1-2.2-2.2-1.9-1.9-1.8-2.1-1.51.5-1.41.4-1.1-0.6-1.3
Locomotion distance, session 30.10.10.2-0.3-0.4-0.4-0.3-0.3-0.3-0.4-0.20.2-0.20.2-0.10.0-0.2
Stereotopy head waving bouts, day 34.04.77.0-2.7-2.4-2.3-2.6-2.4-2.3-2.4-2.12.1-2.12.0-1.8-1.4-1.4
Stereotopy head waving duration, day 32.12.54.2-2.0-1.7-1.7-1.9-1.7-1.7-1.6-1.61.5-1.51.5-1.4-1.1-0.9
Locomotion velocity, session 70.10.10.2-0.2-0.1-0.1-0.3-0.2-0.2-0.1-0.30.3-0.30.3-0.3-0.40.4
Locomotion distance, session 70.60.81.30.60.70.60.80.80.90.11.0-1.01.0-1.01.11.10.9
Stereotopy head waving bouts, day 71.41.52.0-1.1-1.1-1.1-1.3-1.3-1.3-0.4-1.41.4-1.41.4-1.4-1.4-1.0
Stereotopy head waving duration, day 72.02.43.3-1.3-1.4-1.4-1.4-1.5-1.6-0.5-1.81.8-1.81.8-1.8-1.8-1.3
Locomotion velocity, session 83.03.64.8-1.7-1.7-1.8-1.7-1.9-2.0-0.6-2.12.1-2.22.1-2.2-2.2-1.6
Locomotion distance, session 80.60.91.2-0.9-1.0-1.1-0.9-1.0-1.0-0.7-1.01.0-1.01.0-1.0-0.9-0.7
Degree of sensitization distance0.70.71.00.90.91.01.00.90.90.90.8-0.80.8-0.80.70.50.7
Degree of sensitization stereotypy0.20.20.60.20.10.0-0.1-0.1-0.20.7-0.40.4-0.50.5-0.6-0.7-0.3
Conditioned locomotion1.82.12.81.31.31.21.51.41.50.61.6-1.61.6-1.61.71.61.3
Cocaine response after cond. corrected4.35.25.92.32.42.32.42.42.41.62.4-2.42.4-2.42.32.11.9
Cocaine response after cond. not corrected4.14.85.72.32.22.22.42.32.31.52.3-2.32.3-2.32.22.01.8
Cocaine response before conditioning1.01.21.4-1.0-1.2-1.1-1.0-1.2-1.2-0.9-1.11.2-1.11.1-1.1-1.0-1.0
Saline control response0.30.30.40.60.60.50.60.60.60.30.6-0.60.6-0.60.60.60.5
Bone: connectivity density0.71.13.1-0.3-0.4-0.3-0.7-0.7-0.81.1-1.11.2-1.31.3-1.5-1.8-1.2
Bone: cortical apparent density0.60.82.61.11.11.11.21.00.91.60.7-0.70.6-0.60.50.2-0.0
Bone: cortical area0.30.42.10.70.70.60.30.30.21.4-0.30.3-0.40.4-0.8-1.10.3
Bone: cortical porosity0.20.20.60.1-0.2-0.3-0.3-0.4-0.40.3-0.60.6-0.60.6-0.7-0.8-0.1
Bone: cortical porosity0.30.41.20.3-0.0-0.1-0.2-0.3-0.40.8-0.60.7-0.70.7-0.9-1.1-0.3
Bone: cortical thickness0.40.63.81.20.90.90.90.70.52.00.2-0.10.0-0.0-0.3-0.6-0.2
Bone: cortical thickness0.50.61.11.00.70.61.10.80.80.80.8-0.80.8-0.80.80.70.4
Bone: cortical tissue density0.40.62.00.80.90.91.00.80.71.40.5-0.50.5-0.50.30.1-0.2
Condit. Reinf. active minus inactive responses1.01.11.7-1.0-1.2-1.3-1.1-1.2-1.2-1.0-1.11.1-1.11.0-0.9-0.7-0.8
Condit. Reinf. active-inactive response ratio0.10.10.20.30.30.20.20.30.30.00.3-0.30.3-0.30.40.40.4
Condit. Reinf. active responses3.03.75.0-1.8-2.1-2.2-1.9-2.1-2.1-1.4-2.12.0-2.02.0-1.9-1.6-1.6
Condit. Reinf. inactive responses3.44.25.3-2.1-2.3-2.3-2.0-2.2-2.2-1.5-2.22.1-2.12.1-2.0-1.7-1.7
Incentive salience index mean1.51.92.3-1.1-1.3-1.4-1.3-1.4-1.5-0.7-1.51.5-1.51.5-1.5-1.4-1.0
Condit. Reinf. lever presses1.72.44.3-1.1-1.2-1.3-1.2-1.4-1.5-0.1-1.81.8-1.91.9-2.0-2.1-1.1
Condit. Reinf. active minus inactive responses0.60.73.2-1.3-1.0-1.1-1.2-0.8-0.7-1.8-0.30.2-0.20.20.20.6-0.4
Condit. Reinf. active-inactive response ratio0.50.62.2-0.2-0.0-0.0-0.10.30.4-1.00.8-0.80.9-0.91.21.50.5
Condit. Reinf. active responses0.71.02.0-1.3-1.2-1.3-1.3-1.1-1.0-1.4-0.70.7-0.70.6-0.4-0.1-0.9
Condit. Reinf. inactive responses0.50.70.9-0.7-0.8-1.0-0.8-0.9-0.9-0.6-0.90.9-0.90.9-0.8-0.7-0.8
Condit. Reinf. lever presses1.11.54.7-1.7-1.5-1.5-1.6-1.3-1.2-2.2-0.80.7-0.70.6-0.30.2-0.9
Condit. Reinf. lever reinforcers received0.40.61.8-1.0-0.9-1.1-1.0-0.8-0.7-1.3-0.40.4-0.30.3-0.10.3-0.6
Conditioned reinforcement - actives0.00.10.60.80.40.10.30.20.20.40.2-0.10.1-0.10.10.1-0.2
Conditioned reinforcement - inactives0.71.01.11.01.00.91.11.01.00.61.1-1.11.1-1.11.00.90.9
Conditioned locomotion1.62.02.5-1.2-1.5-1.6-1.5-1.6-1.6-1.1-1.51.5-1.51.5-1.3-1.1-1.5
Patch foraging indifference point 0 sec1.73.16.92.32.32.22.12.01.92.61.4-1.31.3-1.20.80.31.2
Patch foraging indifference point AUC0.10.10.8-0.4-0.4-0.4-0.5-0.3-0.3-0.9-0.10.1-0.10.10.10.20.2
Delay disc. indifference point, 0s delay0.40.42.40.40.50.50.30.20.11.6-0.30.4-0.50.5-0.8-1.2-0.1
Delay disc. indifference point, 16s delay0.30.30.7-0.9-0.6-0.6-0.7-0.6-0.6-0.6-0.50.5-0.50.5-0.5-0.4-0.3
Delay disc. indifference point, 2s delay0.10.10.5-0.10.00.2-0.0-0.0-0.10.6-0.30.3-0.40.4-0.5-0.7-0.3
Delay disc. indifference point, 24s delay0.10.10.10.20.30.30.20.30.30.30.2-0.20.2-0.20.20.10.2
Delay disc. indifference point, 4s delay1.01.01.4-1.0-0.9-0.9-1.0-1.0-1.0-0.3-1.11.1-1.11.1-1.2-1.2-1.0
Delay disc. indifference point, 8s delay0.30.40.90.30.50.50.40.60.6-0.10.7-0.70.7-0.70.80.81.0
Indifference point function ln k0.00.00.10.10.20.20.30.30.20.30.2-0.20.1-0.10.1-0.00.3
Indifference point function log k0.00.00.10.10.20.20.30.30.20.30.2-0.20.1-0.10.1-0.00.3
Patch foraging total patch changes 0 sec1.52.86.12.22.22.22.01.91.82.51.4-1.31.2-1.20.80.31.2
Patch foraging total patch changes 12 sec1.82.33.41.81.71.61.81.61.61.41.5-1.51.5-1.51.31.11.0
Patch foraging total patch changes 18 sec0.00.00.10.10.10.1-0.00.0-0.00.1-0.10.1-0.10.1-0.2-0.20.1
Patch foraging total patch changes 24 sec0.10.20.60.80.60.70.40.40.40.70.2-0.10.1-0.1-0.0-0.2-0.3
Patch foraging total patch changes 6 sec1.21.83.61.91.71.61.61.51.41.81.2-1.11.1-1.00.80.40.9
Patch foraging time to switch 0 sec0.10.20.80.1-0.00.10.1-0.1-0.20.8-0.40.4-0.40.4-0.6-0.7-0.9
Patch foraging water rate 0 sec0.71.62.11.21.21.01.21.21.30.51.3-1.31.3-1.31.31.31.4
Patch foraging water rate 12 sec0.91.82.21.41.41.31.51.41.40.91.4-1.41.4-1.41.31.21.3
Patch foraging water rate 18 sec1.32.14.91.00.90.71.01.11.2-0.71.7-1.71.7-1.82.02.21.3
Patch foraging water rate 24 sec4.25.98.52.12.11.82.32.32.40.32.7-2.72.7-2.72.92.92.7
Patch foraging water rate 6 sec0.30.51.60.10.1-0.10.20.30.4-1.00.7-0.70.8-0.81.01.30.8
Seeking ratio, delayed vs. immediate footshock1.61.92.2-1.5-1.5-1.2-1.4-1.5-1.5-0.9-1.51.5-1.41.5-1.4-1.2-1.5
Distance traveled before self-admin1.01.31.8-1.3-1.3-1.3-1.3-1.3-1.3-1.3-1.11.1-1.11.1-0.9-0.6-1.1
Distance traveled after self-admin0.00.00.0-0.2-0.1-0.1-0.1-0.1-0.1-0.2-0.10.1-0.10.1-0.0-0.00.1
Extensor digitorum longus weight4.417.322.54.74.74.74.74.64.54.04.1-4.14.0-3.93.52.83.5
Bone: elastic displacement0.10.10.3-0.2-0.4-0.3-0.3-0.4-0.4-0.1-0.40.4-0.40.4-0.4-0.4-0.5
Bone: elastic work0.10.20.90.60.40.40.40.20.20.9-0.10.1-0.10.1-0.3-0.5-0.1
Bone: endosteal estimation0.41.02.90.91.41.40.71.11.10.90.8-0.80.7-0.70.40.11.7
Bone: endosteal perimeter0.40.91.7-1.0-0.6-0.6-1.2-0.8-0.9-0.5-1.11.1-1.11.1-1.3-1.30.1
Epididymis fat weight0.10.41.20.50.30.20.20.30.4-0.70.6-0.70.7-0.70.91.10.4
Delta time in closed arm before/after self-admin4.64.35.81.71.92.01.92.02.10.52.3-2.32.3-2.32.42.42.0
Delta time in open arm before/after self-admin0.40.40.50.70.70.70.70.70.60.70.6-0.60.5-0.50.40.30.6
Diff in mean of infusions in LGA sessions0.91.12.5-1.1-1.2-1.3-1.3-1.2-1.1-1.6-0.90.9-0.80.8-0.6-0.3-1.0
Delay discount exponential model param0.00.00.20.40.20.20.30.20.20.20.2-0.20.2-0.20.20.20.1
Extinction: sum of active levers before priming0.40.42.3-0.5-0.7-0.9-0.7-0.6-0.5-1.5-0.20.2-0.10.10.20.5-0.3
Active lever presses in extinction session 60.30.30.5-0.1-0.4-0.6-0.5-0.5-0.6-0.2-0.60.6-0.60.6-0.6-0.5-0.7
Bone: final force0.91.44.91.71.61.61.31.31.12.20.6-0.60.5-0.50.0-0.50.9
Bone: final moment0.81.34.81.71.51.51.31.21.12.20.6-0.50.4-0.4-0.0-0.50.8
Food consumed during 24 hour testing period0.10.10.30.20.40.50.20.40.40.20.3-0.30.3-0.30.20.20.5
Glucose0.91.42.41.51.41.51.41.31.31.21.1-1.11.0-1.00.80.60.9
Heart weight0.10.10.4-0.2-0.2-0.1-0.2-0.00.0-0.70.2-0.20.2-0.20.30.50.1
Delay discount hyperbolic model param0.00.00.10.20.0-0.00.10.00.1-0.20.2-0.20.2-0.20.30.30.1
Intermittent access intake day 1-15 change0.10.10.90.1-0.2-0.2-0.2-0.2-0.1-1.00.1-0.10.2-0.20.30.50.0
Intermittent access intake escalation0.10.10.90.1-0.1-0.2-0.2-0.1-0.1-1.00.2-0.20.2-0.20.40.60.2
Intermittent access intake escalation 20.20.20.9-0.4-0.5-0.6-0.5-0.5-0.4-1.0-0.20.2-0.20.2-0.00.2-0.2
Intermitt. access day 1 inactive lever presses0.20.82.30.20.2-0.00.20.30.5-1.30.8-0.90.9-1.01.21.51.4
Intermitt. access day 15 inactive lever presses0.30.61.7-1.0-0.9-1.1-0.9-0.8-0.8-1.3-0.50.5-0.50.4-0.30.0-0.6
Intermitt. access escalation Index0.20.30.9-0.5-0.4-0.3-0.3-0.4-0.40.5-0.60.7-0.70.7-0.8-0.9-0.7
Intermittent access day 1 total infusions0.20.30.50.40.50.40.70.70.70.50.6-0.60.6-0.60.60.50.4
Intermittent access day 15 total infusions0.00.00.00.10.1-0.00.20.10.10.20.1-0.10.1-0.10.0-0.0-0.2
Intermittent access terminal intake (last 3 days)0.10.20.4-0.2-0.3-0.4-0.3-0.3-0.40.2-0.50.5-0.50.5-0.6-0.6-0.6
Intermittent access total infusions0.10.10.30.40.30.20.40.30.30.60.2-0.10.1-0.10.0-0.1-0.0
Intermittent access day 1 locomotion0.50.61.20.50.60.40.70.70.7-0.10.9-0.90.9-0.91.01.01.1
Intermittent access day 15 total locomotion0.00.10.2-0.1-0.1-0.20.10.00.1-0.50.2-0.20.2-0.20.30.40.3
Intermittent access total locomotion0.00.00.10.0-0.1-0.20.0-0.00.0-0.40.1-0.10.1-0.10.20.30.1
Intermittent access standard deviation0.40.81.4-1.0-1.0-1.2-0.9-0.9-0.9-0.6-0.90.9-0.90.9-0.9-0.8-0.9
Left kidney weight0.00.10.3-0.3-0.1-0.10.0-0.00.0-0.60.2-0.20.2-0.20.30.40.1
Right kidney weight0.10.31.9-0.7-0.7-0.8-0.5-0.5-0.5-1.4-0.10.1-0.10.00.20.5-0.0
Cocaine induced anxiety2.33.34.6-1.3-1.6-1.5-1.8-1.9-1.9-0.8-2.02.0-2.02.0-2.0-1.9-2.2
Post-drug Anxiety3.13.36.5-1.0-1.3-1.1-1.6-1.7-1.8-0.0-2.02.1-2.12.1-2.2-2.3-2.5
Baseline Anxiety0.00.00.0-0.00.10.20.10.10.10.20.0-0.00.0-0.0-0.0-0.1-0.1
Tail length2.28.718.6-3.7-3.7-3.7-3.5-3.4-3.2-4.3-2.52.4-2.32.2-1.6-0.7-2.0
Length with tail0.83.411.0-2.5-2.3-2.4-2.2-2.0-1.9-3.3-1.31.2-1.11.0-0.50.1-0.9
Length without tail0.31.11.40.91.00.91.11.11.10.51.1-1.11.1-1.11.11.01.2
Times rat made contact with spout1.61.82.31.41.51.41.21.41.40.81.4-1.41.4-1.41.31.21.5
Lifetime Intake0.30.41.60.90.80.70.80.70.61.30.4-0.40.3-0.30.1-0.10.0
Liver weight, left0.20.30.60.70.70.60.50.60.60.30.6-0.50.5-0.50.50.40.8
Liver weight, right0.10.10.9-0.3-0.1-0.2-0.2-0.10.0-1.00.2-0.30.3-0.30.50.60.3
Locomotor activity4.67.18.5-2.7-2.8-2.9-2.9-2.9-2.9-2.3-2.82.7-2.72.7-2.5-2.1-2.4
Locomotor testing distance1.93.43.9-1.8-1.8-1.9-2.0-2.0-2.0-1.5-1.91.9-1.91.9-1.8-1.5-1.7
Locomotor testing rearing0.00.10.3-0.00.1-0.0-0.10.00.1-0.60.2-0.20.2-0.20.30.40.3
Locomotion in novel chamber0.10.10.30.50.40.30.30.30.30.30.3-0.20.3-0.20.20.10.2
Locomotion in novel chamber post-restriction2.23.65.7-2.2-2.1-2.2-2.4-2.1-2.0-2.4-1.71.7-1.61.6-1.3-0.8-1.8
Fecal boli incidents, locomotor time 11.01.41.71.11.21.21.11.21.30.51.3-1.31.3-1.31.31.21.2
Change in fecal boli incidents, locomotor task1.91.82.5-1.3-1.3-1.2-1.1-1.3-1.4-0.2-1.51.5-1.51.5-1.6-1.6-1.4
Time >=10cm from walls, locomotor time 10.20.20.90.00.20.20.10.0-0.10.9-0.40.4-0.40.4-0.7-0.90.1
Bouts of movement, locomotor time 10.40.41.2-1.0-0.8-1.0-0.8-0.7-0.6-1.1-0.40.4-0.40.4-0.2-0.00.2
Total resting periods, locomotor time 11.01.12.1-1.4-1.3-1.4-1.3-1.1-1.1-1.5-0.90.8-0.80.8-0.6-0.3-0.3
Rest time, locomotor task time 10.80.91.2-1.0-1.0-1.1-1.1-1.0-1.1-0.8-1.01.0-1.01.0-0.9-0.8-0.6
Distance moved, locomotor task time 10.30.42.10.60.40.50.50.20.11.4-0.30.3-0.40.4-0.7-1.0-0.7
Vertical activity count, locomotor time 10.51.32.71.61.41.41.41.21.21.41.0-1.00.9-0.90.80.50.5
Time >=10cm from walls, locomotor time 21.01.52.11.01.21.31.31.31.30.91.3-1.31.3-1.21.21.01.4
Bouts of movement, locomotor time 20.61.01.4-1.1-0.9-1.1-1.0-1.0-1.0-0.3-1.11.1-1.11.1-1.2-1.2-0.4
Total resting periods, locomotor time 20.71.21.8-1.2-1.0-1.2-1.0-1.0-1.1-0.2-1.21.2-1.21.2-1.3-1.3-0.5
Rest time, locomotor task time 20.50.71.0-0.9-0.7-0.7-0.7-0.7-0.8-0.1-0.90.9-0.90.9-1.0-1.0-0.8
Distance moved, locomotor task time 20.30.30.70.60.40.30.50.50.5-0.00.6-0.60.7-0.70.80.80.4
Vertical activity count, locomotor time 21.72.42.81.61.51.41.61.61.60.81.7-1.71.7-1.71.71.61.2
Light reinforcement 13.27.910.3-3.1-3.1-3.2-2.9-3.1-3.0-2.4-2.82.8-2.82.7-2.5-2.0-2.6
Light reinforcement 21.72.63.7-1.9-1.9-1.9-1.6-1.8-1.8-1.4-1.61.6-1.61.6-1.4-1.2-1.4
Bone: marrow area0.41.02.80.91.41.40.71.11.10.80.8-0.80.7-0.70.50.21.7
Bone: maximum diameter0.71.42.7-0.9-0.7-0.7-1.4-1.0-1.1-0.5-1.31.4-1.41.4-1.6-1.60.1
Bone: maximum force1.01.85.31.91.81.81.41.51.32.30.8-0.80.7-0.60.2-0.31.1
Bone: maximum moment1.01.75.21.81.81.71.41.41.32.30.8-0.70.6-0.60.2-0.31.0
Mean time between licks in bursts0.10.31.1-0.8-0.7-0.7-0.7-0.6-0.5-1.0-0.40.3-0.30.3-0.10.1-0.3
Mean num. licks in bursts0.81.21.5-1.1-1.1-1.1-1.1-1.2-1.2-0.7-1.21.2-1.21.2-1.1-1.0-0.9
Cd content in liver0.10.10.2-0.2-0.3-0.2-0.4-0.3-0.3-0.0-0.40.4-0.40.4-0.4-0.3-0.5
Co content in liver1.82.13.6-1.8-1.8-1.9-1.7-1.7-1.6-1.8-1.31.2-1.21.1-0.8-0.4-1.3
Cu content in liver0.20.20.80.30.40.50.30.20.10.9-0.20.2-0.30.3-0.6-0.80.3
Fe content in liver0.60.80.90.90.90.90.80.90.90.40.9-0.90.9-0.90.90.80.9
K content in liver1.61.61.8-1.3-1.3-1.1-1.3-1.3-1.3-0.6-1.41.3-1.41.3-1.3-1.2-1.2
Mg content in liver1.31.31.8-1.3-1.2-1.2-1.3-1.2-1.2-1.0-1.21.1-1.11.1-1.0-0.8-1.0
Mn content in liver4.14.56.7-1.8-1.9-1.8-2.0-2.1-2.2-0.5-2.42.4-2.52.5-2.6-2.6-1.6
Na content in liver0.10.10.50.30.30.40.00.10.10.7-0.10.2-0.20.2-0.4-0.6-0.1
Rb content in liver0.10.20.7-0.10.20.4-0.10.0-0.10.6-0.30.3-0.40.4-0.6-0.8-0.0
Se content in liver0.00.00.10.20.10.20.10.20.20.10.1-0.10.1-0.10.10.10.3
Sr content in liver0.10.10.2-0.0-0.3-0.3-0.1-0.1-0.1-0.40.1-0.10.2-0.20.30.5-0.4
Zn content in liver0.80.85.2-1.1-1.0-1.0-1.0-0.7-0.6-2.3-0.0-0.10.1-0.20.61.1-0.0
Bone: minimum diameter0.10.21.00.20.40.4-0.10.10.00.7-0.30.4-0.40.4-0.7-1.00.5
Time in familiar zone, hab. session 12.12.06.6-1.9-1.7-1.7-1.8-1.5-1.4-2.6-1.01.0-0.90.9-0.5-0.0-0.6
Time in novel zone, hab. session 10.90.95.01.41.21.21.20.80.72.20.2-0.20.1-0.1-0.3-0.70.2
Total zone transitions, hab. session 11.41.93.1-1.0-1.1-1.2-1.3-1.4-1.4-0.3-1.61.6-1.71.7-1.7-1.8-0.9
Total locomotion distance, hab. session 14.05.67.6-2.1-2.1-2.2-2.4-2.4-2.5-1.0-2.72.7-2.72.7-2.8-2.7-1.7
Locomotion velocity, hab. session 13.65.16.4-2.1-2.2-2.2-2.3-2.3-2.4-1.1-2.52.5-2.52.5-2.5-2.4-1.6
Time in familiar zone, hab. session 22.82.97.7-2.2-2.3-2.3-1.8-1.9-1.8-2.8-1.21.2-1.11.1-0.6-0.0-1.4
Time in novel zone, hab. session 22.92.98.72.22.32.41.81.91.73.01.1-1.11.0-0.90.4-0.21.3
Total zone transitions, hab. session 20.91.24.2-0.0-0.2-0.2-0.1-0.5-0.71.4-1.21.2-1.31.3-1.7-2.0-0.9
Total locomotion distance, hab. session 21.82.33.3-1.3-1.4-1.5-1.3-1.5-1.6-0.5-1.71.7-1.81.8-1.8-1.8-1.1
Locomotion velocity, hab. session 22.43.24.8-1.5-1.6-1.6-1.5-1.7-1.8-0.5-2.02.1-2.12.1-2.2-2.2-1.3
Novel to familiar place preference ratio0.90.94.11.41.31.31.10.90.82.00.3-0.30.2-0.2-0.2-0.70.6
Novelty place preference0.60.62.71.11.01.00.80.70.61.60.2-0.10.0-0.0-0.3-0.70.5
Time in novel zone, NPP test0.80.93.61.41.31.21.10.90.81.90.4-0.30.3-0.2-0.1-0.50.7
Total zone transitions, NPP test0.20.31.20.1-0.0-0.1-0.0-0.2-0.30.8-0.60.6-0.70.7-0.9-1.1-0.5
Total locomotion distance, NPP test0.70.92.2-0.6-0.6-0.6-0.6-0.8-0.80.3-1.11.1-1.21.2-1.3-1.5-0.8
Locomotion velocity, NPP test0.91.32.3-0.9-0.9-0.9-0.9-1.0-1.1-0.0-1.31.3-1.31.3-1.4-1.5-0.9
Intraocular pressure0.20.31.2-0.3-0.2-0.2-0.00.10.2-1.10.5-0.50.6-0.60.91.10.3
Delta distance traveled before/after self-admin0.60.60.80.70.80.90.90.80.80.70.8-0.80.8-0.80.70.60.8
Delta ambulatory time before/after self-admin0.20.30.80.50.60.70.60.60.50.90.4-0.40.3-0.30.20.00.5
Parametrial fat weight0.20.51.10.80.80.90.90.80.71.10.6-0.50.5-0.50.30.10.5
Pavlov. Cond. lever latency1.11.33.10.60.80.80.80.91.0-0.51.3-1.41.4-1.41.61.81.0
Pavlov. Cond. magazine entry latency1.21.52.3-1.4-1.5-1.5-1.3-1.4-1.3-1.3-1.21.1-1.11.1-0.9-0.7-0.9
Pavlov. Cond. change in total contacts0.10.10.30.50.30.30.50.30.30.60.2-0.20.2-0.20.10.00.1
Pavlov. Cond. index score1.11.41.7-1.0-1.2-1.2-1.0-1.2-1.2-0.4-1.31.3-1.31.3-1.3-1.3-1.0
Pavlov. Cond. latency score1.41.82.5-1.1-1.2-1.2-1.2-1.3-1.4-0.3-1.51.5-1.51.5-1.6-1.6-1.1
Pavlov. Cond. lever contacts0.91.02.6-0.4-0.6-0.6-0.5-0.8-0.90.6-1.21.2-1.31.3-1.4-1.6-0.8
Pavlov. Cond. magazine entry number0.40.50.80.80.90.90.70.80.80.90.6-0.60.6-0.60.40.20.4
Pavlov. Cond. intertrial magazine entries0.30.31.00.20.10.10.20.30.4-0.60.6-0.70.7-0.70.91.00.4
Pavlov. Cond. lever-magazine prob. diff.1.01.21.5-0.9-1.2-1.2-1.0-1.2-1.2-0.4-1.21.2-1.21.2-1.2-1.1-1.0
Pavlov. Cond. response bias0.40.50.7-0.7-0.9-0.9-0.7-0.8-0.8-0.7-0.70.7-0.60.6-0.5-0.4-0.5
Pavlov. Cond. lever latency1.21.73.01.71.51.51.61.41.41.71.1-1.11.0-1.00.70.41.1
Pavlov. Cond. magazine entry latency1.92.33.8-2.0-1.8-1.8-1.8-1.7-1.6-1.9-1.41.3-1.31.2-1.0-0.6-1.0
Pavlov. Cond. change in total contacts0.40.61.4-1.0-1.0-1.0-1.0-0.9-0.9-1.2-0.60.6-0.60.5-0.3-0.1-0.5
Pavlov. Cond. index score1.31.83.5-1.8-1.7-1.6-1.7-1.5-1.4-1.9-1.11.1-1.01.0-0.7-0.3-0.9
Pavlov. Cond. latency score1.72.33.9-2.0-1.8-1.8-1.8-1.7-1.6-1.9-1.41.3-1.21.2-1.0-0.6-1.1
Pavlov. Cond. lever contacts0.91.23.1-1.6-1.3-1.3-1.4-1.2-1.1-1.8-0.80.8-0.70.7-0.4-0.0-0.7
Pavlov. Cond. magazine entry number1.92.43.81.91.91.91.81.71.71.91.4-1.41.3-1.31.00.61.1
Pavlov. Cond. intertrial magazine entries1.31.92.31.51.51.51.51.51.51.11.5-1.41.4-1.41.31.11.1
Pavlov. Cond. lever-magazine prob. diff.1.62.13.6-1.9-1.8-1.7-1.7-1.6-1.5-1.9-1.31.2-1.21.1-0.9-0.5-1.0
Pavlov. Cond. response bias1.31.84.6-1.9-1.7-1.6-1.7-1.5-1.4-2.1-1.00.9-0.90.8-0.5-0.0-0.9
Time in closed arm before self-admin0.30.41.1-0.4-0.4-0.2-0.3-0.4-0.50.5-0.70.7-0.80.8-0.9-1.1-0.7
Time in closed arm after self-admin0.40.50.80.40.70.90.90.80.80.80.7-0.70.7-0.70.60.40.5
Time in open arm before self-admin0.00.10.20.40.30.10.20.20.20.10.2-0.20.2-0.20.20.20.2
Time in open arm after self-admin1.51.72.21.51.51.21.41.41.41.11.3-1.31.3-1.31.11.01.2
Bone: periosteal estimation0.30.62.00.91.21.20.50.80.61.40.2-0.10.1-0.0-0.4-0.81.2
Bone: periosteal perimeter0.40.82.4-0.4-0.2-0.3-0.8-0.6-0.70.4-1.01.0-1.11.1-1.4-1.6-0.1
Bone: post-yield work0.71.01.61.01.21.10.91.11.10.61.0-1.01.0-0.90.80.71.3
Progressive ratio test 1 active lever presses0.40.51.01.00.80.70.90.80.80.80.7-0.70.7-0.70.60.50.4
Progressive ratio test 1 breakpoint0.50.61.11.00.90.70.90.80.80.70.7-0.70.7-0.70.60.50.4
Progressive ratio test 1 inactive lever presses0.10.10.3-0.2-0.4-0.6-0.2-0.3-0.3-0.3-0.30.3-0.30.3-0.2-0.2-0.6
Progressive ratio test 2 active lever presses0.00.00.10.1-0.1-0.4-0.1-0.2-0.2-0.1-0.20.2-0.20.2-0.2-0.10.0
Progressive ratio test 2 breakpoint0.10.10.3-0.1-0.2-0.5-0.2-0.3-0.3-0.2-0.30.3-0.30.3-0.3-0.2-0.0
Progressive ratio test 2 inactive lever presses0.10.10.50.50.1-0.10.1-0.1-0.10.7-0.30.3-0.30.3-0.5-0.6-0.6
Incentive Sensitization - Responses0.20.30.6-0.5-0.6-0.8-0.6-0.6-0.5-0.8-0.40.4-0.40.4-0.3-0.10.3
Incentive Sensitization - Breakpoint0.40.51.0-0.8-0.8-1.0-0.8-0.8-0.7-0.9-0.60.6-0.60.6-0.5-0.30.0
Sum of active levers in priming session hrs 5-60.00.00.2-0.0-0.1-0.1-0.3-0.2-0.2-0.4-0.10.1-0.00.10.00.1-0.3
Progressive ratio1.21.93.41.31.41.31.51.51.51.11.4-1.41.4-1.41.31.11.8
Food seeking constrained by brief footshock1.11.42.9-1.3-1.4-1.5-1.5-1.3-1.2-1.7-1.00.9-0.90.9-0.7-0.3-0.8
Seeking ratio, punishment vs. effort1.92.74.1-1.8-1.9-1.8-2.0-1.8-1.8-2.0-1.51.5-1.41.4-1.2-0.8-1.8
Retroperitoneal fat weight2.510.613.93.63.43.43.73.53.52.53.4-3.33.3-3.33.12.72.7
Reaction time number correct1.32.63.11.41.61.41.61.61.70.61.7-1.81.8-1.81.71.71.7
Reaction time mean minus median0.61.52.2-1.4-1.5-1.4-1.3-1.4-1.3-1.4-1.21.2-1.11.1-0.9-0.7-1.1
Reaction time mean minus median AUC1.43.44.0-1.9-1.9-1.8-1.8-1.9-1.9-0.9-2.02.0-2.02.0-1.9-1.8-1.8
Reaction time num false alarms0.30.40.60.60.70.70.80.70.70.70.7-0.60.6-0.60.60.40.8
Reaction time num false alarms AUC0.40.60.70.60.80.70.80.80.80.60.8-0.80.8-0.80.70.60.9
Reaction time trials correct on left1.32.63.11.41.61.41.61.61.70.61.7-1.81.8-1.81.71.71.7
Reaction time trials on left1.32.42.81.31.61.41.51.61.60.61.7-1.71.7-1.71.71.61.7
Reaction time mean1.42.22.6-1.5-1.5-1.4-1.5-1.5-1.6-0.9-1.61.6-1.61.6-1.6-1.5-1.1
Reaction time mean AUC0.71.11.7-1.0-1.0-0.8-1.1-1.0-1.1-0.4-1.21.2-1.21.2-1.3-1.3-0.7
Median of all reaction times1.01.51.9-1.2-1.1-1.0-1.2-1.2-1.2-0.6-1.41.4-1.41.4-1.4-1.4-0.8
Reaction time omissions0.10.20.6-0.2-0.2-0.1-0.2-0.3-0.40.3-0.50.5-0.50.6-0.6-0.7-0.4
Reaction time false alarm rate0.00.00.1-0.1-0.1-0.0-0.0-0.1-0.10.3-0.20.2-0.20.2-0.3-0.4-0.2
Reaction time premature initiation rate0.70.93.1-1.1-1.3-1.5-0.9-1.0-0.9-1.8-0.60.5-0.50.4-0.10.2-0.8
Reaction time premature initiations0.20.42.1-0.3-0.4-0.6-0.0-0.10.0-1.40.4-0.50.6-0.60.91.20.2
Std. dev. reaction times0.71.21.4-1.1-1.1-1.1-1.1-1.2-1.2-0.8-1.21.2-1.21.2-1.2-1.1-0.9
Reaction time trials completed1.32.42.81.31.61.41.51.61.60.61.7-1.71.7-1.71.71.61.7
Reaction time trials AUC1.52.93.61.51.71.51.71.71.80.61.9-1.91.9-1.91.91.81.8
Run reversals in cocaine runway, females2.92.93.8-1.9-1.9-2.0-1.8-1.8-1.8-1.3-1.81.7-1.71.7-1.6-1.4-1.0
Run reversals in cocaine runway, males2.72.73.8-1.6-1.6-1.6-1.8-1.7-1.7-0.9-1.71.7-1.71.7-1.6-1.4-1.9
Latency to leave start box in cocaine runway0.70.81.9-0.4-0.5-0.3-0.6-0.7-0.80.4-1.01.1-1.11.1-1.2-1.4-1.2
Latency to leave start box in cocaine runway, F1.11.33.2-0.6-0.5-0.3-0.7-0.7-0.80.9-1.21.3-1.31.3-1.6-1.8-1.5
Latency to leave start box in cocaine runway, M0.10.10.20.20.00.10.10.10.1-0.40.2-0.20.3-0.30.40.50.4
Std. dev. time between licks in bursts0.91.31.6-1.1-1.0-1.0-1.2-1.2-1.2-0.6-1.31.2-1.21.2-1.2-1.2-1.0
Total sessions with >9 infusions0.30.31.50.80.70.70.70.60.51.20.3-0.30.2-0.20.0-0.2-0.2
Short access day 1 total inactive lever presses0.10.10.7-0.7-0.4-0.5-0.3-0.2-0.2-0.80.0-0.00.1-0.10.20.4-0.1
Short access day 10 total inactive lever presses0.41.02.60.30.50.30.50.70.8-0.81.1-1.21.2-1.21.41.61.4
Short access day 1 total infusions0.30.31.40.70.70.70.70.60.61.20.4-0.30.3-0.30.1-0.1-0.0
Short access day 10 total infusions0.20.20.50.40.50.40.70.60.60.70.5-0.50.5-0.50.40.3-0.0
Short access total infusions0.40.52.20.80.80.80.90.80.71.50.4-0.40.3-0.30.1-0.20.0
Short access day 1 locomotion0.10.10.4-0.4-0.3-0.4-0.2-0.2-0.2-0.6-0.00.0-0.0-0.00.10.2-0.1
Short access day 10 total locomotion0.20.52.6-0.5-0.5-0.8-0.4-0.3-0.1-1.60.2-0.30.4-0.40.71.10.5
Short access total locomotion0.00.00.2-0.1-0.1-0.3-0.0-0.1-0.0-0.50.1-0.10.1-0.20.30.4-0.1
One hour access (0.3 mA shock)0.30.40.80.90.70.50.60.60.60.40.6-0.60.6-0.60.50.50.5
Compulsive drug intake0.10.10.2-0.5-0.4-0.1-0.4-0.3-0.3-0.1-0.30.3-0.30.4-0.4-0.4-0.1
One hour access (shock baseline)0.00.10.20.50.2-0.10.20.10.1-0.00.2-0.20.2-0.20.30.3-0.1
Social response proportion1.11.22.0-1.4-1.2-1.3-1.2-1.2-1.2-0.9-1.11.1-1.11.1-0.9-0.7-1.0
Social responses8.410.914.6-3.8-3.6-3.7-3.8-3.6-3.6-3.3-3.33.2-3.13.1-2.7-2.2-2.6
Social time1.11.52.01.31.41.31.41.31.31.21.2-1.21.2-1.21.10.90.9
Soleus weight3.39.619.74.03.73.83.83.43.34.42.7-2.62.5-2.51.91.11.6
Bone: stiffness2.43.97.42.52.62.52.22.22.12.71.6-1.61.5-1.51.00.41.8
Tibialis anterior weight0.93.15.62.12.22.42.02.01.92.31.6-1.51.5-1.41.10.71.2
Time to tail flick, vehicle, before self-admin1.92.03.4-1.5-1.4-1.2-1.3-1.4-1.4-0.6-1.51.5-1.51.5-1.4-1.4-1.9
Time to tail flick, vehicle, after self-admin0.30.41.3-0.1-0.0-0.30.10.20.3-1.00.6-0.60.7-0.70.91.10.5
Time to tail flick, test, before self-admin1.71.82.3-1.3-1.3-1.2-1.2-1.3-1.4-0.4-1.51.5-1.51.5-1.5-1.5-1.1
Time to tail flick, test, after self-admin0.10.10.3-0.3-0.2-0.1-0.2-0.2-0.20.2-0.40.4-0.40.4-0.5-0.6-0.4
Delta time to tail flick, vehicle, before/after SA3.02.83.81.51.51.31.51.71.70.41.9-1.91.9-1.91.91.92.0
Delta time to tail flick, test, before/after SA0.70.71.60.50.60.60.60.70.8-0.41.0-1.01.0-1.01.11.20.7
Tibia length0.51.55.4-1.6-1.4-1.5-1.5-1.3-1.2-2.3-0.90.8-0.70.7-0.4-0.0-0.2
Ambulatory time before self-admin0.20.30.6-0.5-0.6-0.7-0.7-0.6-0.6-0.7-0.50.5-0.50.5-0.4-0.3-0.8
Ambulatory time after self-admin0.00.00.00.0-0.00.0-0.1-0.1-0.1-0.0-0.10.1-0.10.1-0.1-0.1-0.1
Bone: tissue strength3.03.06.32.32.22.31.91.91.82.51.4-1.31.2-1.20.80.31.3
Total heroin consumption2.12.53.1-1.6-1.7-1.7-1.8-1.7-1.7-1.4-1.61.6-1.51.5-1.4-1.1-1.7
Bone: trabecular number1.52.43.8-1.1-1.2-1.1-1.5-1.4-1.50.0-1.71.8-1.81.8-1.9-2.0-1.7
Bone: trabecular spacing1.82.35.00.91.00.81.51.31.4-0.41.8-1.81.8-1.92.12.21.4
Bone: trabecular thickness2.73.49.0-0.7-0.9-0.8-1.3-1.4-1.51.1-2.12.2-2.32.3-2.7-3.0-1.7
Bone: trabecular tissue density5.07.49.52.93.03.13.13.03.02.42.8-2.72.7-2.62.31.92.4
Water consumed over 24 hours0.10.20.90.40.50.50.20.30.21.0-0.10.1-0.10.1-0.4-0.60.2
Number of responses in last shaping day0.50.52.5-0.4-0.8-0.9-0.9-0.8-0.8-1.6-0.40.4-0.40.4-0.10.2-0.3