Hub : Genes

Rad1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Rad1 0.1 0.06 2.3e-05 0.04 0.05 0.04 0.04 4.8e-04 4.1e-05 2.8e-04 2.7e-04
2 Brain mRNA stability Rad1 0.12 0.05 3.5e-14 0.12 0.14 0.13 0.15 5.2e-11 4.7e-13 2.9e-12 1.4e-13
3 PL mRNA stability Rad1 0.07 0.03 9.9e-08 0.08 0.07 0.06 0.07 9.0e-09 1.7e-08 1.8e-07 2.1e-08
4 Brain gene expression Rad1 0.14 0.06 6.5e-15 0.15 0.15 0.15 0.15 1.2e-13 3.6e-14 1.0e-13 4.1e-14
5 IC gene expression Rad1 0.43 0.15 5.6e-17 0.36 0.09 0.29 0.07 5.1e-16 2.0e-04 1.0e-12 7.0e-04
6 NAcc mRNA stability Rad1 0.08 0.04 5.2e-13 0.05 0.08 0.08 0.07 1.4e-08 4.0e-12 8.0e-12 2.4e-11
7 NAcc gene expression Rad1 0.3 0.07 0.0e+00 0.43 0.42 0.43 0.44 2.5e-71 6.7e-70 1.1e-71 1.6e-72
8 BLA gene expression Rad1 0.28 0.11 2.6e-12 0.22 0.2 0.21 0.21 1.2e-11 6.5e-11 1.5e-11 1.5e-11
9 IL mRNA stability Rad1 0.19 0.1 9.8e-04 0.14 0.12 0.13 0.13 3.6e-04 7.2e-04 5.7e-04 5.2e-04
10 OFC gene expression Rad1 0.33 0.13 7.2e-05 0.16 0.13 0.11 0.13 1.2e-04 5.4e-04 1.5e-03 5.5e-04
11 IL gene expression Rad1 0.39 0.12 1.7e-08 0.2 0.33 0.28 0.29 1.3e-05 1.2e-08 1.5e-07 9.4e-08
12 Adipose gene expression Rad1 0.06 0.03 3.0e-08 0.04 0.05 0.05 0.05 5.8e-05 1.6e-06 2.6e-06 2.9e-06
13 PL gene expression Rad1 0.34 0.09 0.0e+00 0.38 0.39 0.38 0.38 1.1e-43 9.6e-45 1.4e-43 2.2e-44
14 Liver gene expression Rad1 0.23 0.09 0.0e+00 0.19 0.2 0.21 0.2 2.1e-20 3.2e-22 1.6e-22 5.4e-22
15 BLA mRNA stability Rad1 0.09 0.05 9.0e-04 0.04 0.05 0.04 0.05 1.9e-03 1.4e-03 2.8e-03 1.9e-03
16 Liver isoform ratio XM_006232059.5 0.03 0.03 6.1e-03 0 0 -0 -0 2.1e-01 3.1e-01 6.7e-01 7.1e-01
17 Adipose mRNA stability Rad1 0.09 0.05 1.0e-07 0.04 0.06 0.03 0.05 4.4e-05 3.9e-07 9.2e-05 7.3e-06
18 IC mRNA stability Rad1 0.09 0.05 2.0e-03 -0 0.01 0.01 0 3.8e-01 1.1e-01 7.5e-02 2.1e-01
19 Eye gene expression Rad1 0.41 0.16 2.4e-03 0.07 0.05 0.1 0.06 3.2e-02 6.1e-02 1.3e-02 3.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
Bone: apparent density0.61.14.3-1.0-0.7-0.2-0.6-0.20.60.0-0.1-0.0-0.0-1.11.3-0.30.91.5-1.12.02.1-1.7
Area under the delay curve0.10.10.4-0.20.3-0.2-0.1-0.20.2-0.3-0.5-0.6-0.6-0.20.2-0.10.30.0-0.0-0.10.20.5
BMI with tail6.321.727.6-4.7-4.7-5.2-4.8-5.0-4.9-5.1-5.2-5.3-5.3-3.9-4.8-4.7-4.7-5.2-3.2-5.0-3.4-1.8
BMI without tail5.516.922.5-4.5-4.7-4.3-4.3-4.2-4.6-4.5-4.3-4.4-4.4-3.4-4.2-4.2-4.0-4.0-4.0-3.7-2.8-2.8
Body weight5.524.030.3-5.1-5.2-5.5-5.1-5.3-5.4-5.2-5.2-5.3-5.3-4.1-5.0-5.1-4.9-5.1-4.1-4.9-3.7-2.5
Weight adjusted by age0.81.32.5-1.1-0.9-1.6-1.2-1.4-0.9-1.2-1.0-1.1-1.1-1.5-0.9-1.4-1.0-1.1-0.4-0.9-1.40.3
Bone surface0.40.83.4-1.4-0.7-1.1-1.1-1.10.1-0.8-1.0-0.9-0.9-1.80.4-1.10.10.3-0.50.50.6-0.3
Bone volume0.40.73.2-1.1-0.7-0.8-0.9-0.80.4-0.6-0.8-0.6-0.6-1.80.8-0.90.30.6-0.31.01.1-0.4
Breakpoint value in progressive ratio session0.10.20.5-0.5-0.5-0.4-0.5-0.4-0.1-0.5-0.5-0.5-0.5-0.7-0.1-0.5-0.3-0.0-0.20.20.1-0.5
Number of licking bursts1.11.94.5-0.6-0.7-1.3-1.4-1.3-0.8-1.4-1.2-1.4-1.4-2.1-1.5-1.4-1.7-1.50.2-1.3-2.10.9
Context. condit. distance diff. score0.60.73.3-0.2-0.20.40.30.50.10.50.50.50.50.90.90.51.01.2-1.11.21.4-1.8
Locomotion velocity, session 10.50.64.00.60.5-0.10.2-0.10.1-0.10.10.10.10.1-0.5-0.1-0.4-0.91.4-1.3-1.22.0
Locomotion distance, session 10.30.42.40.30.3-0.2-0.0-0.2-0.1-0.4-0.1-0.1-0.1-0.2-0.7-0.2-0.6-0.90.7-1.3-1.31.6
Locomotion velocity, session 20.00.00.2-0.10.2-0.1-0.0-0.10.20.0-0.1-0.1-0.1-0.10.2-0.00.1-0.20.3-0.20.50.2
Locomotion distance, session 20.30.42.10.30.4-0.3-0.1-0.30.3-0.3-0.2-0.2-0.2-0.6-0.4-0.3-0.5-0.71.3-0.9-0.81.5
Locomotion velocity, session 30.60.73.21.31.00.60.60.60.40.50.80.80.80.6-0.30.7-0.3-0.50.9-0.9-1.11.8
Locomotion distance, session 31.51.77.71.00.2-0.5-0.5-0.5-0.7-0.4-0.3-0.3-0.3-0.7-1.9-0.4-2.1-1.80.6-2.2-2.82.0
Stereotopy head waving bouts, day 30.50.61.80.00.40.80.60.80.60.60.70.70.70.61.00.71.11.1-0.51.31.1-0.5
Stereotopy head waving duration, day 30.81.02.7-0.20.40.90.80.90.70.60.80.80.81.01.40.91.71.4-0.41.51.6-0.7
Locomotion velocity, session 70.30.31.30.80.40.10.30.10.20.10.30.20.20.2-0.30.2-0.5-0.51.1-0.7-0.81.1
Locomotion distance, session 70.10.10.70.60.20.10.20.20.40.00.20.10.1-0.30.10.0-0.20.10.80.1-0.20.8
Stereotopy head waving bouts, day 70.10.10.50.50.20.0-0.1-0.10.00.00.30.10.1-0.5-0.4-0.1-0.5-0.30.3-0.3-0.70.6
Stereotopy head waving duration, day 70.30.30.90.90.60.70.60.50.50.70.90.80.80.40.20.60.20.30.50.30.00.3
Locomotion velocity, session 80.10.10.60.40.40.10.20.20.20.20.30.20.20.0-0.20.1-0.3-0.30.7-0.4-0.60.8
Locomotion distance, session 80.00.00.10.00.10.00.10.10.20.10.30.30.30.10.30.10.20.3-0.10.10.2-0.3
Degree of sensitization distance1.01.15.1-0.4-0.10.50.40.50.80.40.30.30.30.41.70.41.61.6-0.11.82.3-1.3
Degree of sensitization stereotypy0.60.71.6-0.4-0.8-0.8-1.0-0.9-0.8-0.7-0.5-0.6-0.6-1.1-1.1-0.9-1.2-0.9-0.7-0.7-1.0-0.4
Conditioned locomotion0.20.21.0-0.4-0.3-0.1-0.1-0.1-0.00.10.10.10.10.00.4-0.10.30.5-0.80.60.8-1.0
Cocaine response after cond. corrected1.82.24.6-1.6-1.6-1.8-1.7-1.8-1.1-1.7-1.8-1.7-1.7-2.1-1.1-1.8-1.3-1.0-0.8-0.6-0.8-0.6
Cocaine response after cond. not corrected4.85.79.7-2.6-2.4-2.8-2.7-2.8-2.0-2.7-2.9-2.7-2.7-3.1-2.0-2.8-2.2-1.9-1.5-1.4-1.7-0.9
Cocaine response before conditioning1.21.42.1-1.2-1.0-1.2-1.2-1.2-1.4-1.1-1.4-1.2-1.2-0.9-1.3-1.1-1.0-1.2-1.1-1.2-1.4-0.4
Saline control response0.50.72.30.0-0.3-0.7-0.8-0.7-0.3-0.8-0.6-0.6-0.6-1.5-1.0-0.8-1.1-0.90.3-0.8-1.40.6
Bone: connectivity density0.61.04.1-0.10.20.40.20.41.10.70.50.50.5-0.31.60.31.31.7-0.12.02.0-0.9
Bone: cortical apparent density0.40.51.10.70.60.90.80.90.50.70.80.70.71.00.60.90.70.60.10.50.50.0
Bone: cortical area0.20.22.0-0.6-0.7-0.0-0.3-0.0-0.5-0.1-0.10.10.10.3-0.1-0.10.10.1-1.10.10.4-1.4
Bone: cortical porosity0.10.10.2-0.4-0.3-0.2-0.1-0.3-0.4-0.2-0.2-0.2-0.20.1-0.5-0.1-0.3-0.4-0.2-0.3-0.3-0.3
Bone: cortical porosity0.30.30.6-0.7-0.5-0.5-0.4-0.6-0.7-0.5-0.5-0.5-0.5-0.1-0.8-0.4-0.5-0.7-0.3-0.6-0.6-0.2
Bone: cortical thickness0.30.53.1-0.7-0.80.1-0.10.1-1.0-0.10.00.10.11.1-0.40.10.0-0.2-1.5-0.20.2-1.8
Bone: cortical thickness0.10.10.2-0.3-0.1-0.10.1-0.0-0.1-0.3-0.4-0.3-0.30.40.0-0.10.1-0.20.4-0.40.20.3
Bone: cortical tissue density0.30.40.90.60.60.90.70.90.50.60.80.70.70.90.60.90.60.60.10.50.40.1
Condit. Reinf. active minus inactive responses1.61.82.61.41.31.51.31.51.61.31.41.51.50.91.41.31.31.41.31.41.00.7
Condit. Reinf. active-inactive response ratio0.30.31.00.60.60.60.60.60.50.40.50.60.60.60.30.50.40.21.00.1-0.10.8
Condit. Reinf. active responses3.64.56.22.32.22.32.12.32.52.12.32.32.31.42.32.12.12.21.82.01.81.0
Condit. Reinf. inactive responses2.22.74.92.21.81.81.61.71.91.81.91.81.81.11.61.61.51.61.41.41.30.8
Incentive salience index mean2.93.64.81.71.82.01.92.02.11.92.02.02.01.52.21.82.12.11.52.01.80.7
Condit. Reinf. lever presses3.75.27.92.02.32.32.32.32.42.42.42.42.42.12.72.32.82.51.62.22.40.6
Condit. Reinf. active minus inactive responses0.10.10.70.30.5-0.2-0.0-0.20.10.1-0.1-0.1-0.1-0.3-0.2-0.1-0.2-0.30.5-0.4-0.80.8
Condit. Reinf. active-inactive response ratio0.20.20.60.20.1-0.4-0.2-0.4-0.3-0.1-0.3-0.3-0.3-0.3-0.7-0.2-0.7-0.60.2-0.8-0.80.5
Condit. Reinf. active responses0.10.20.6-0.10.3-0.4-0.3-0.40.1-0.1-0.4-0.3-0.3-0.8-0.1-0.3-0.1-0.30.2-0.3-0.70.8
Condit. Reinf. inactive responses0.00.00.2-0.00.1-0.0-0.1-0.00.20.10.00.10.1-0.30.3-0.10.50.3-0.30.40.20.0
Condit. Reinf. lever presses0.10.20.80.00.1-0.4-0.4-0.4-0.3-0.2-0.4-0.3-0.3-0.5-0.6-0.3-0.5-0.60.2-0.6-0.90.6
Condit. Reinf. lever reinforcers received0.30.41.2-0.10.1-0.7-0.5-0.7-0.2-0.3-0.6-0.5-0.5-0.9-0.5-0.5-0.5-0.60.1-0.7-1.10.9
Conditioned reinforcement - actives0.10.20.80.70.30.40.40.4-0.20.40.20.30.30.9-0.30.4-0.1-0.3-0.0-0.6-0.30.3
Conditioned reinforcement - inactives0.20.31.30.70.20.30.30.3-0.70.40.20.40.41.2-0.70.4-0.3-0.7-0.1-1.1-0.50.0
Conditioned locomotion0.70.92.71.61.21.01.11.00.40.90.80.90.91.3-0.11.0-0.0-0.11.1-0.4-0.61.5
Patch foraging indifference point 0 sec0.20.40.6-0.6-0.7-0.4-0.7-0.5-0.4-0.8-0.8-0.8-0.8-0.8-0.5-0.6-0.7-0.6-0.5-0.50.1-0.3
Patch foraging indifference point AUC0.20.30.8-0.4-0.5-0.9-0.7-0.9-0.4-0.5-0.7-0.7-0.7-0.8-0.5-0.7-0.5-0.50.1-0.4-0.4-0.2
Delay disc. indifference point, 0s delay0.60.73.21.21.30.50.80.51.00.70.50.40.40.30.60.50.50.41.80.2-0.01.6
Delay disc. indifference point, 16s delay0.30.41.1-0.9-0.4-0.5-0.6-0.5-0.2-0.7-0.9-1.0-1.0-0.60.2-0.50.10.1-1.00.10.4-0.4
Delay disc. indifference point, 2s delay0.40.51.0-0.8-0.6-0.7-0.7-0.7-0.6-0.8-0.8-1.0-1.0-0.7-0.5-0.6-0.4-0.6-0.9-0.60.1-0.4
Delay disc. indifference point, 24s delay0.10.10.3-0.6-0.1-0.4-0.2-0.3-0.2-0.3-0.6-0.6-0.6-0.20.0-0.30.10.1-0.60.10.20.0
Delay disc. indifference point, 4s delay0.20.20.60.20.70.30.50.20.50.30.30.10.10.40.50.40.80.30.40.10.50.5
Delay disc. indifference point, 8s delay0.20.21.10.10.4-0.3-0.0-0.30.0-0.2-0.4-0.6-0.6-0.1-0.2-0.2-0.0-0.40.5-0.6-0.41.1
Indifference point function ln k1.32.33.11.01.21.71.71.71.31.51.71.61.61.81.71.61.71.70.61.51.80.0
Indifference point function log k1.32.33.11.01.21.71.71.71.31.51.71.61.61.81.71.61.71.70.61.51.80.0
Patch foraging total patch changes 0 sec0.40.81.2-1.0-1.0-0.7-1.0-0.8-0.8-1.1-1.1-1.1-1.1-0.9-0.8-0.9-0.9-0.9-0.8-0.8-0.1-0.5
Patch foraging total patch changes 12 sec2.02.63.5-1.3-1.6-1.6-1.8-1.7-1.7-1.6-1.8-1.9-1.9-1.5-1.7-1.6-1.8-1.7-1.2-1.5-1.2-1.1
Patch foraging total patch changes 18 sec2.03.14.8-1.1-1.6-1.9-1.8-2.0-1.8-1.7-1.9-1.9-1.9-1.7-2.1-1.8-2.1-2.2-0.6-2.0-1.5-0.3
Patch foraging total patch changes 24 sec7.112.115.6-3.1-3.2-3.8-3.7-3.8-3.5-3.7-3.9-3.9-3.9-3.6-3.8-3.7-3.8-3.7-1.9-3.3-3.3-1.0
Patch foraging total patch changes 6 sec2.23.35.0-2.1-2.0-2.0-2.1-2.0-1.6-2.0-2.2-2.2-2.2-2.1-1.3-1.9-1.6-1.4-1.8-1.0-0.4-1.4
Patch foraging time to switch 0 sec0.20.41.2-0.2-0.5-0.6-0.8-0.5-0.4-0.6-0.6-0.6-0.6-1.1-0.7-0.6-0.9-0.5-0.7-0.4-0.8-0.1
Patch foraging water rate 0 sec0.20.31.4-0.7-0.40.30.30.2-0.40.10.30.40.41.10.20.40.70.3-0.90.20.8-1.2
Patch foraging water rate 12 sec0.81.83.2-1.5-1.3-1.4-1.2-1.4-1.8-1.3-1.2-1.1-1.1-0.7-1.7-1.3-1.3-1.5-1.0-1.4-1.5-0.8
Patch foraging water rate 18 sec0.81.24.4-0.9-0.5-0.9-0.7-0.9-1.3-0.9-0.9-0.8-0.8-0.4-1.6-0.8-1.2-1.6-0.5-1.8-2.10.3
Patch foraging water rate 24 sec1.01.43.10.61.01.31.51.20.81.21.31.31.31.81.21.31.51.10.61.01.0-0.3
Patch foraging water rate 6 sec0.30.41.6-1.0-0.8-0.4-0.3-0.4-1.1-0.4-0.6-0.5-0.50.5-0.6-0.4-0.1-0.4-0.8-0.4-0.1-1.3
Seeking ratio, delayed vs. immediate footshock0.60.81.61.00.91.01.11.00.70.91.21.01.01.30.61.10.60.50.80.30.70.4
Distance traveled before self-admin0.50.71.8-0.4-0.8-0.5-0.5-0.5-1.1-0.7-0.4-0.5-0.5-0.0-1.3-0.5-1.2-1.3-0.5-1.3-1.3-0.0
Distance traveled after self-admin0.40.51.90.0-0.1-0.4-0.2-0.3-0.5-0.5-0.3-0.3-0.3-0.1-0.9-0.3-0.8-1.10.3-1.4-1.31.0
Extensor digitorum longus weight0.31.21.9-1.0-1.1-1.1-1.1-1.0-1.3-1.1-0.8-0.9-0.9-0.9-1.4-0.9-1.2-1.2-1.3-1.2-1.0-0.7
Bone: elastic displacement0.40.42.20.0-0.50.2-0.00.2-1.00.20.30.20.21.0-0.70.2-0.6-0.5-1.3-0.7-0.3-1.5
Bone: elastic work1.82.45.2-1.7-2.1-1.4-1.7-1.4-2.0-1.3-1.4-1.4-1.4-0.9-1.4-1.5-1.5-1.2-2.3-1.0-0.5-2.3
Bone: endosteal estimation1.73.89.0-2.2-2.2-2.2-2.5-2.2-1.4-2.3-2.3-2.0-2.0-3.0-1.1-2.4-1.6-1.1-1.5-0.7-0.6-1.3
Bone: endosteal perimeter0.10.31.2-0.4-0.6-0.6-0.7-0.5-0.2-0.6-0.5-0.4-0.4-1.1-0.3-0.7-0.5-0.2-0.1-0.1-0.2-0.1
Epididymis fat weight0.72.44.4-1.5-2.1-1.4-1.5-1.4-2.0-1.8-1.5-1.5-1.5-0.6-1.7-1.5-1.6-1.7-1.5-1.6-0.5-1.7
Delta time in closed arm before/after self-admin0.10.10.50.70.10.30.10.40.30.30.40.40.4-0.5-0.20.1-0.40.40.40.6-0.3-0.2
Delta time in open arm before/after self-admin0.40.41.1-0.5-0.6-0.4-0.4-0.4-1.0-0.5-0.5-0.5-0.50.3-0.8-0.3-0.8-0.9-1.1-1.0-0.5-0.5
Diff in mean of infusions in LGA sessions0.10.21.5-0.4-0.4-0.1-0.2-0.1-0.4-0.1-0.2-0.2-0.20.1-0.20.0-0.10.1-0.90.20.4-1.2
Delay discount exponential model param0.10.10.50.4-0.10.30.20.3-0.00.40.60.70.70.3-0.10.2-0.20.10.20.2-0.1-0.4
Extinction: sum of active levers before priming0.10.10.40.40.30.30.40.30.10.40.60.60.60.5-0.00.30.10.10.20.0-0.40.3
Active lever presses in extinction session 61.41.43.2-0.6-0.6-1.4-1.2-1.2-0.6-1.3-1.3-1.3-1.3-1.8-1.1-1.3-1.3-1.2-0.0-1.1-1.40.9
Bone: final force1.21.83.2-1.8-1.7-1.5-1.6-1.5-1.3-1.4-1.7-1.4-1.4-1.5-1.0-1.5-1.0-0.8-1.6-0.6-0.3-1.2
Bone: final moment2.13.45.6-2.4-2.3-1.9-2.1-1.9-2.0-1.8-2.1-1.9-1.9-1.8-1.4-1.9-1.4-1.2-2.3-0.9-0.5-1.9
Food consumed during 24 hour testing period0.30.40.8-0.6-0.4-0.7-0.5-0.7-0.7-0.3-0.6-0.7-0.7-0.3-0.9-0.5-0.7-0.8-0.0-0.8-0.50.1
Glucose2.33.75.4-2.2-2.2-2.1-2.2-2.1-1.8-2.2-2.0-2.2-2.2-2.3-1.7-2.2-1.8-1.4-1.9-1.0-1.1-1.2
Heart weight0.00.00.20.40.20.20.20.20.10.10.20.20.20.2-0.00.20.1-0.10.5-0.2-0.30.2
Delay discount hyperbolic model param0.10.10.60.5-0.00.40.30.40.00.40.60.70.70.4-0.10.3-0.20.10.30.2-0.2-0.3
Intermittent access intake day 1-15 change0.20.31.0-0.7-0.8-0.3-0.5-0.5-0.8-0.6-0.5-0.4-0.40.0-0.6-0.4-0.4-0.7-1.0-0.7-0.2-0.7
Intermittent access intake escalation0.10.21.0-0.6-0.6-0.1-0.3-0.2-0.6-0.4-0.3-0.2-0.20.2-0.3-0.2-0.1-0.3-1.0-0.40.2-0.9
Intermittent access intake escalation 20.70.82.5-1.2-1.1-0.7-0.9-0.8-1.0-0.8-0.8-0.8-0.8-0.5-0.6-0.7-0.5-0.5-1.6-0.4-0.1-1.4
Intermitt. access day 1 inactive lever presses0.10.42.10.30.5-0.3-0.1-0.3-0.1-0.2-0.4-0.4-0.4-0.3-0.6-0.2-0.5-0.80.7-1.0-1.11.4
Intermitt. access day 15 inactive lever presses0.30.51.8-0.0-0.1-0.6-0.4-0.6-0.8-0.5-0.5-0.5-0.5-0.3-1.1-0.5-0.8-1.1-0.0-1.2-1.30.8
Intermitt. access escalation Index0.81.23.6-0.8-1.1-1.1-1.3-1.1-0.6-1.4-1.0-1.1-1.1-1.9-0.9-1.4-1.3-0.80.1-0.5-1.20.4
Intermittent access day 1 total infusions0.60.91.61.01.20.91.00.90.81.21.01.11.11.30.91.21.00.70.20.20.90.7
Intermittent access day 15 total infusions0.10.21.5-0.5-0.1-0.0-0.0-0.0-0.30.10.00.20.20.60.30.20.50.0-1.2-0.30.7-0.5
Intermittent access terminal intake (last 3 days)0.81.04.5-1.6-1.1-1.0-0.9-1.0-1.2-0.9-0.9-0.8-0.8-0.2-0.4-0.7-0.2-0.7-2.1-0.90.2-1.1
Intermittent access total infusions0.10.10.7-0.4-0.1-0.1-0.0-0.1-0.20.0-0.10.10.10.40.10.10.3-0.1-0.8-0.40.3-0.0
Intermittent access day 1 locomotion1.01.23.51.61.51.01.21.01.01.11.11.21.21.10.61.10.60.31.3-0.10.11.9
Intermittent access day 15 total locomotion0.10.21.50.70.70.40.40.40.30.40.40.50.50.50.20.40.3-0.10.2-0.4-0.11.2
Intermittent access total locomotion0.10.10.9-0.10.0-0.3-0.2-0.3-0.2-0.2-0.2-0.1-0.10.0-0.3-0.1-0.2-0.6-0.2-0.9-0.40.8
Intermittent access standard deviation0.00.10.4-0.2-0.20.10.1-0.1-0.3-0.0-0.00.10.10.50.00.10.2-0.2-0.6-0.40.40.1
Left kidney weight3.717.023.8-4.9-4.8-4.6-4.6-4.5-4.4-4.6-4.3-4.4-4.4-3.9-3.6-4.3-3.7-3.5-4.5-3.1-2.6-3.1
Right kidney weight3.817.526.1-5.1-4.9-4.6-4.7-4.5-4.3-4.6-4.5-4.6-4.6-4.0-3.4-4.4-3.5-3.3-4.7-2.8-2.2-3.4
Cocaine induced anxiety0.91.23.0-1.2-1.2-0.8-1.0-0.9-1.5-1.0-1.1-1.1-1.1-0.3-1.2-0.8-1.0-1.1-1.7-1.2-0.4-1.2
Post-drug Anxiety0.80.81.7-0.8-0.9-0.6-0.7-0.7-1.3-0.8-1.0-1.1-1.1-0.0-1.1-0.7-0.9-1.1-1.0-1.3-0.5-0.7
Baseline Anxiety0.60.71.61.30.90.90.90.90.71.00.90.90.90.90.50.80.50.51.20.50.10.6
Tail length0.72.710.4-2.2-2.3-1.3-1.7-1.3-1.7-1.5-1.2-1.2-1.2-1.3-0.9-1.4-1.0-0.4-3.20.0-0.2-3.0
Length with tail1.35.57.5-2.7-2.6-2.7-2.7-2.6-2.3-2.5-2.3-2.4-2.4-2.5-2.0-2.6-2.1-1.9-2.5-1.7-1.7-1.5
Length without tail1.23.75.8-1.5-1.3-2.3-1.9-2.2-1.6-2.0-2.1-2.1-2.1-2.0-2.0-2.1-2.0-2.3-0.3-2.4-2.30.8
Times rat made contact with spout2.42.85.2-1.5-1.6-1.7-1.5-1.7-2.2-1.5-1.6-1.6-1.6-1.0-2.3-1.5-1.9-1.9-1.5-1.7-1.9-0.8
Lifetime Intake0.10.20.5-0.00.20.20.30.20.30.30.30.50.50.60.60.40.70.3-0.50.00.70.1
Liver weight, left1.72.85.3-2.1-2.1-1.7-2.0-1.7-1.6-1.8-1.7-1.7-1.7-1.9-1.1-1.7-1.3-1.0-2.3-0.7-0.7-1.8
Liver weight, right1.22.24.1-1.6-1.0-1.8-1.6-1.7-0.9-1.6-1.9-1.7-1.7-2.0-1.2-1.5-1.4-1.5-0.7-1.3-1.20.6
Locomotor activity0.20.31.1-0.4-0.6-0.2-0.6-0.3-0.1-0.4-0.4-0.4-0.4-0.80.1-0.4-0.20.3-0.90.40.9-1.1
Locomotor testing distance0.10.10.40.2-0.3-0.2-0.3-0.1-0.5-0.2-0.2-0.2-0.2-0.1-0.6-0.2-0.6-0.4-0.3-0.5-0.2-0.4
Locomotor testing rearing0.10.10.5-0.0-0.5-0.1-0.5-0.0-0.3-0.3-0.1-0.2-0.2-0.5-0.3-0.2-0.4-0.1-0.6-0.0-0.1-0.7
Locomotion in novel chamber0.71.03.80.60.61.11.21.20.31.11.21.21.22.00.61.21.00.60.10.30.7-0.1
Locomotion in novel chamber post-restriction0.10.21.10.20.50.10.30.10.30.20.30.30.30.30.20.20.2-0.20.7-0.4-0.21.1
Fecal boli incidents, locomotor time 14.97.19.02.92.72.93.02.92.63.02.92.92.92.92.52.72.52.42.52.12.01.7
Change in fecal boli incidents, locomotor task0.20.20.6-0.4-0.2-0.5-0.4-0.4-0.5-0.3-0.00.10.1-0.4-0.6-0.3-0.6-0.5-0.6-0.6-0.8-0.1
Time >=10cm from walls, locomotor time 10.40.41.01.00.80.50.60.40.30.60.60.70.70.7-0.20.5-0.0-0.30.8-0.5-0.71.0
Bouts of movement, locomotor time 14.65.310.32.42.22.72.22.62.82.21.61.51.51.32.92.12.53.01.93.22.60.4
Total resting periods, locomotor time 13.53.87.32.11.92.41.82.32.41.81.41.31.31.12.41.92.02.61.62.72.20.4
Rest time, locomotor task time 12.73.44.72.11.92.22.02.11.92.01.71.71.71.81.91.91.81.91.71.81.60.9
Distance moved, locomotor task time 10.50.81.2-1.1-0.9-1.0-0.9-0.8-0.9-1.0-0.7-0.7-0.7-0.8-1.0-0.8-0.9-1.1-1.0-1.1-1.1-0.3
Vertical activity count, locomotor time 10.92.22.9-1.7-1.5-1.4-1.4-1.4-1.6-1.7-1.6-1.7-1.7-1.1-1.5-1.4-1.4-1.5-1.3-1.5-1.4-0.8
Time >=10cm from walls, locomotor time 20.50.71.50.60.50.90.70.90.60.91.11.21.20.80.70.90.70.8-0.30.80.9-0.6
Bouts of movement, locomotor time 21.32.14.11.61.61.51.41.62.01.11.11.01.00.71.91.41.61.71.41.81.50.8
Total resting periods, locomotor time 21.32.24.71.71.71.61.41.62.21.01.11.01.00.51.91.31.51.81.71.81.31.1
Rest time, locomotor task time 21.92.46.41.81.71.71.61.52.01.31.21.21.20.71.61.21.41.52.51.50.81.8
Distance moved, locomotor task time 21.11.35.2-1.5-1.6-1.0-1.2-0.9-1.3-1.0-0.8-0.8-0.8-0.7-0.9-0.8-0.9-0.7-2.3-0.5-0.1-2.0
Vertical activity count, locomotor time 20.60.84.2-1.0-1.1-0.4-0.7-0.3-1.2-0.6-0.5-0.6-0.60.2-0.8-0.4-0.6-0.5-2.1-0.40.1-1.8
Light reinforcement 10.20.41.3-0.4-0.3-0.7-0.6-0.7-0.5-0.8-0.7-0.6-0.6-0.6-0.7-0.6-0.6-0.9-0.3-1.1-1.00.4
Light reinforcement 20.20.31.30.3-0.3-0.0-0.2-0.0-0.7-0.3-0.2-0.2-0.20.2-0.9-0.3-0.7-0.8-0.2-0.9-1.1-0.1
Bone: marrow area1.63.58.6-2.2-2.2-2.2-2.4-2.1-1.3-2.2-2.2-2.0-2.0-2.9-1.0-2.3-1.5-1.0-1.6-0.6-0.5-1.4
Bone: maximum diameter0.30.52.0-1.0-1.0-0.5-0.9-0.5-0.4-0.6-0.6-0.3-0.3-0.9-0.0-0.6-0.20.1-1.20.30.4-1.4
Bone: maximum force1.52.74.7-2.2-2.0-1.9-1.9-1.9-1.3-1.8-2.0-1.8-1.8-2.1-0.8-2.0-1.1-0.9-1.5-0.6-0.1-1.2
Bone: maximum moment2.54.37.5-2.7-2.6-2.4-2.4-2.3-1.9-2.2-2.5-2.2-2.2-2.3-1.3-2.4-1.5-1.3-2.2-0.9-0.3-2.0
Mean time between licks in bursts0.82.13.9-0.7-1.0-1.4-1.3-1.4-1.2-1.5-1.5-1.5-1.5-1.4-1.7-1.5-1.8-2.00.1-2.0-1.60.6
Mean num. licks in bursts0.40.62.8-0.1-0.30.50.60.5-0.60.70.40.60.61.70.10.70.60.4-1.10.41.2-1.7
Cd content in liver0.10.10.20.1-0.10.20.10.2-0.30.30.30.20.20.5-0.20.2-0.2-0.0-0.50.00.1-0.5
Co content in liver1.11.23.61.00.81.31.21.30.61.51.11.31.31.90.71.41.00.80.30.81.2-0.6
Cu content in liver2.32.84.52.11.81.91.81.91.81.81.81.91.91.41.41.91.31.31.71.21.11.1
Fe content in liver0.81.04.01.61.10.80.90.80.90.70.80.80.80.40.00.7-0.00.02.0-0.1-0.72.0
K content in liver0.10.10.7-0.30.00.10.10.10.10.1-0.00.00.00.30.40.30.40.2-0.50.20.8-0.5
Mg content in liver0.80.81.90.70.91.01.01.00.70.90.91.01.01.40.81.20.90.60.30.41.10.1
Mn content in liver0.00.10.30.00.20.20.10.20.20.20.10.20.2-0.00.20.30.20.2-0.50.20.3-0.3
Na content in liver0.80.92.10.10.30.90.80.90.21.00.91.01.01.40.71.11.00.8-1.10.81.2-1.3
Rb content in liver1.61.82.71.51.61.41.51.41.51.41.31.41.41.21.21.41.21.11.50.90.81.3
Se content in liver0.10.20.50.70.70.40.40.40.50.40.20.40.40.00.10.4-0.00.30.50.2-0.10.7
Sr content in liver2.21.92.8-1.3-1.7-1.5-1.4-1.5-1.6-1.5-1.4-1.5-1.5-1.2-1.4-1.6-1.4-1.4-0.8-1.1-1.2-0.6
Zn content in liver1.92.14.21.01.41.51.61.51.41.61.31.51.51.71.71.71.81.40.91.42.00.2
Bone: minimum diameter0.61.01.7-0.7-1.0-1.0-1.1-1.0-1.1-1.0-1.0-0.8-0.8-1.0-1.3-1.1-1.2-1.2-0.3-1.3-1.30.1
Time in familiar zone, hab. session 10.90.91.81.41.01.11.11.00.91.01.01.11.10.90.70.90.90.71.20.60.30.8
Time in novel zone, hab. session 10.40.40.9-1.0-0.8-0.7-0.8-0.7-0.5-0.6-0.5-0.5-0.5-0.9-0.3-0.7-0.6-0.0-0.80.40.2-0.9
Total zone transitions, hab. session 12.33.25.02.01.72.01.92.01.81.92.22.12.11.81.72.01.81.51.31.11.40.6
Total locomotion distance, hab. session 10.50.71.41.20.71.00.81.00.90.71.01.01.00.60.70.90.60.70.50.50.70.2
Locomotion velocity, hab. session 10.30.40.80.90.60.80.70.80.60.50.90.90.90.70.50.80.60.40.20.00.40.2
Time in familiar zone, hab. session 20.50.64.0-0.9-0.6-0.00.0-0.1-0.40.20.00.00.00.70.50.10.90.7-1.00.81.2-2.0
Time in novel zone, hab. session 20.50.52.40.60.1-0.2-0.4-0.20.1-0.5-0.3-0.3-0.3-1.1-0.8-0.4-1.2-0.70.6-0.7-1.21.5
Total zone transitions, hab. session 20.10.10.5-0.3-0.4-0.2-0.4-0.2-0.4-0.4-0.2-0.2-0.2-0.2-0.4-0.2-0.3-0.4-0.7-0.5-0.3-0.1
Total locomotion distance, hab. session 20.81.01.3-0.9-1.0-1.0-1.1-1.0-1.1-1.2-1.1-1.1-1.1-0.9-1.1-1.0-1.0-1.1-1.0-1.2-0.8-0.2
Locomotion velocity, hab. session 20.70.91.3-0.9-1.0-1.0-1.0-1.0-1.0-1.1-1.0-1.0-1.0-0.8-0.9-0.9-0.8-0.9-1.1-1.0-0.6-0.4
Novel to familiar place preference ratio0.60.72.5-1.2-0.6-0.9-0.9-0.80.0-0.8-1.0-0.9-0.9-1.60.4-1.0-0.10.3-0.60.60.6-0.5
Novelty place preference0.80.82.5-1.4-0.9-1.0-1.1-0.9-0.2-0.8-1.0-1.0-1.0-1.60.3-1.1-0.10.3-1.00.60.7-1.0
Time in novel zone, NPP test0.70.82.1-1.3-0.9-0.9-1.0-0.8-0.2-0.8-1.0-0.9-0.9-1.40.4-1.0-0.10.4-1.00.70.7-1.0
Total zone transitions, NPP test0.30.41.5-0.6-0.6-0.4-0.4-0.4-1.0-0.6-0.3-0.3-0.30.4-0.9-0.3-0.4-0.9-0.9-1.2-0.8-0.4
Total locomotion distance, NPP test0.20.20.9-0.2-0.2-0.2-0.2-0.2-0.6-0.5-0.6-0.5-0.50.2-0.6-0.1-0.2-0.7-0.5-0.9-0.60.1
Locomotion velocity, NPP test0.20.20.8-0.4-0.2-0.3-0.3-0.3-0.6-0.6-0.7-0.6-0.60.1-0.5-0.2-0.2-0.7-0.7-0.9-0.5-0.1
Intraocular pressure0.50.72.4-0.7-1.1-0.9-1.1-0.8-0.5-0.9-0.9-0.8-0.8-1.5-0.5-1.0-0.9-0.1-0.80.2-0.1-1.3
Delta distance traveled before/after self-admin0.10.10.80.10.4-0.00.20.00.1-0.00.00.00.00.1-0.10.00.0-0.30.3-0.5-0.50.9
Delta ambulatory time before/after self-admin0.10.10.5-0.50.0-0.4-0.2-0.4-0.2-0.4-0.4-0.3-0.3-0.2-0.2-0.3-0.1-0.5-0.0-0.7-0.40.5
Parametrial fat weight1.53.68.2-0.8-1.1-2.0-1.9-2.0-0.9-2.0-1.8-2.0-2.0-2.9-1.9-2.1-2.3-2.10.9-2.1-2.31.7
Pavlov. Cond. lever latency1.41.84.1-0.7-1.2-1.2-1.1-1.2-1.6-1.3-1.2-1.1-1.1-0.9-2.0-1.2-2.0-1.7-0.5-1.6-1.9-0.1
Pavlov. Cond. magazine entry latency0.40.51.6-0.20.20.40.20.40.40.50.40.40.40.31.10.41.21.1-0.51.21.3-0.9
Pavlov. Cond. change in total contacts0.10.10.5-0.3-0.1-0.2-0.3-0.30.3-0.2-0.1-0.1-0.1-0.70.7-0.30.50.5-0.20.60.6-0.1
Pavlov. Cond. index score0.91.23.40.00.60.80.70.80.90.90.80.80.80.71.70.81.81.6-0.31.61.9-0.8
Pavlov. Cond. latency score1.01.33.80.20.80.90.80.91.11.00.90.90.90.71.80.91.81.7-0.11.61.9-0.6
Pavlov. Cond. lever contacts1.21.53.40.71.21.11.11.11.31.31.21.11.11.01.71.11.81.50.51.41.60.1
Pavlov. Cond. magazine entry number0.70.82.40.3-0.1-0.6-0.4-0.6-0.4-0.7-0.5-0.5-0.5-0.7-1.3-0.5-1.5-1.40.8-1.4-1.61.4
Pavlov. Cond. intertrial magazine entries0.10.20.70.5-0.10.00.00.1-0.40.00.00.10.10.2-0.80.1-0.8-0.60.2-0.6-0.6-0.0
Pavlov. Cond. lever-magazine prob. diff.0.81.03.0-0.10.50.60.50.60.80.80.70.60.60.51.60.61.61.5-0.41.51.7-0.9
Pavlov. Cond. response bias0.70.82.6-0.10.50.60.50.60.70.80.60.60.60.61.40.61.61.4-0.31.41.5-0.8
Pavlov. Cond. lever latency0.50.72.0-1.3-1.1-0.8-1.0-0.8-0.6-0.8-0.7-0.8-0.8-1.0-0.1-1.0-0.4-0.0-1.40.20.2-1.4
Pavlov. Cond. magazine entry latency0.50.61.31.10.81.00.91.00.60.90.91.01.01.00.41.00.40.50.60.40.20.4
Pavlov. Cond. change in total contacts0.60.92.81.61.30.81.00.80.50.90.70.80.81.0-0.20.9-0.1-0.31.7-0.6-0.81.6
Pavlov. Cond. index score0.50.72.01.41.10.80.90.80.60.80.80.80.80.8-0.00.90.1-0.01.3-0.2-0.51.4
Pavlov. Cond. latency score0.81.02.41.51.31.01.11.00.81.01.01.01.01.10.21.10.30.21.5-0.0-0.31.5
Pavlov. Cond. lever contacts0.70.92.31.51.30.91.10.90.60.90.80.90.91.20.01.10.3-0.01.5-0.4-0.41.5
Pavlov. Cond. magazine entry number1.01.22.4-1.5-1.2-1.3-1.2-1.3-1.0-1.2-1.3-1.3-1.3-1.3-0.7-1.3-0.7-0.7-1.1-0.5-0.3-0.9
Pavlov. Cond. intertrial magazine entries0.50.81.4-0.9-0.8-0.9-1.0-0.9-1.0-1.0-0.9-1.1-1.1-0.9-0.8-1.0-0.6-0.7-1.2-0.7-0.9-0.5
Pavlov. Cond. lever-magazine prob. diff.0.70.92.41.51.20.91.00.90.70.90.80.90.90.90.11.00.20.11.5-0.2-0.51.6
Pavlov. Cond. response bias0.40.61.51.21.00.70.90.70.50.80.60.80.81.0-0.00.90.2-0.01.1-0.3-0.41.1
Time in closed arm before self-admin0.10.21.2-0.20.5-0.20.1-0.30.1-0.1-0.2-0.2-0.20.20.1-0.10.5-0.40.7-0.7-0.31.1
Time in closed arm after self-admin0.10.10.80.30.60.00.10.00.40.20.20.20.2-0.40.10.00.20.10.70.0-0.50.9
Time in open arm before self-admin0.30.31.8-0.6-0.8-0.3-0.5-0.3-0.6-0.5-0.5-0.5-0.5-0.3-0.4-0.4-0.5-0.0-0.90.30.2-1.3
Time in open arm after self-admin0.70.81.9-0.4-0.9-0.5-0.7-0.5-1.2-0.7-0.7-0.7-0.7-0.1-1.3-0.6-1.4-1.1-1.2-1.1-0.9-0.7
Bone: periosteal estimation1.12.33.8-1.9-2.0-1.6-1.9-1.6-1.3-1.7-1.7-1.4-1.4-1.9-0.9-1.7-1.2-0.8-1.7-0.6-0.3-1.6
Bone: periosteal perimeter0.20.30.6-0.7-0.7-0.6-0.8-0.5-0.5-0.7-0.5-0.4-0.4-0.7-0.4-0.6-0.5-0.3-0.8-0.3-0.4-0.5
Bone: post-yield work0.20.31.4-0.10.30.10.30.10.80.1-0.00.10.1-0.01.10.20.90.60.80.61.20.5
Progressive ratio test 1 active lever presses0.50.61.10.91.00.80.80.71.00.70.70.90.90.50.90.80.80.70.80.40.51.1
Progressive ratio test 1 breakpoint0.50.61.10.80.90.70.70.71.00.70.70.80.80.40.90.70.80.60.80.40.51.1
Progressive ratio test 1 inactive lever presses0.00.10.80.10.30.00.1-0.00.10.1-0.10.00.00.10.10.10.2-0.20.2-0.4-0.10.9
Progressive ratio test 2 active lever presses0.20.21.20.50.10.50.50.5-0.10.60.50.60.61.10.10.60.30.1-0.3-0.10.5-0.2
Progressive ratio test 2 breakpoint0.10.10.80.4-0.00.30.40.3-0.20.40.40.50.50.90.00.40.1-0.0-0.3-0.30.3-0.2
Progressive ratio test 2 inactive lever presses0.10.10.50.60.10.30.20.2-0.30.50.30.40.40.7-0.10.4-0.1-0.1-0.5-0.20.3-0.2
Incentive Sensitization - Responses0.71.03.7-1.0-1.4-0.7-0.8-0.7-1.6-0.6-0.7-0.6-0.60.3-0.9-0.6-0.6-0.8-1.9-0.8-0.0-1.8
Incentive Sensitization - Breakpoint0.91.24.3-1.1-1.6-0.8-0.9-0.8-1.7-0.7-0.7-0.7-0.70.2-1.0-0.7-0.7-0.9-2.1-0.8-0.0-1.9
Sum of active levers in priming session hrs 5-60.10.10.2-0.10.0-0.3-0.1-0.20.0-0.2-0.2-0.2-0.2-0.4-0.3-0.2-0.4-0.20.2-0.1-0.30.3
Progressive ratio1.42.24.11.11.21.41.41.51.61.51.41.41.41.22.01.41.92.00.52.02.0-0.1
Food seeking constrained by brief footshock2.12.64.3-1.3-1.6-1.8-1.8-1.7-1.5-1.6-1.6-1.5-1.5-1.9-1.8-1.6-2.1-1.6-1.5-1.4-1.7-0.4
Seeking ratio, punishment vs. effort2.84.06.8-1.6-1.7-2.0-1.9-2.0-2.1-1.9-1.9-1.9-1.9-1.6-2.6-1.8-2.5-2.5-1.2-2.5-2.5-0.1
Retroperitoneal fat weight1.14.67.0-1.7-2.3-2.3-2.4-2.3-1.8-2.6-2.4-2.5-2.5-2.7-2.0-2.4-2.5-2.1-1.1-1.9-1.4-0.4
Reaction time number correct0.51.02.0-1.3-1.2-1.1-0.9-1.1-1.4-1.0-1.1-0.9-0.9-0.3-1.1-1.0-0.6-1.1-1.1-1.0-0.3-1.0
Reaction time mean minus median0.81.93.41.01.41.21.31.11.71.31.51.31.31.01.81.31.61.61.11.31.80.9
Reaction time mean minus median AUC0.41.01.70.81.10.81.10.71.30.91.10.90.90.81.31.01.21.01.20.71.11.2
Reaction time num false alarms0.20.31.0-0.5-0.8-0.7-0.9-0.7-0.2-0.8-0.5-0.6-0.6-1.0-0.1-0.7-0.6-0.3-0.3-0.20.1-0.4
Reaction time num false alarms AUC0.20.31.0-0.3-0.7-0.6-0.9-0.6-0.2-0.7-0.4-0.6-0.6-1.0-0.3-0.7-0.7-0.4-0.2-0.3-0.1-0.3
Reaction time trials correct on left0.51.02.0-1.3-1.2-1.1-0.9-1.1-1.4-1.0-1.1-0.9-0.9-0.3-1.1-1.0-0.6-1.1-1.1-1.0-0.3-1.0
Reaction time trials on left0.61.12.2-1.4-1.3-1.2-1.0-1.1-1.5-1.1-1.2-1.0-1.0-0.4-1.1-1.0-0.7-1.2-1.1-1.1-0.3-1.1
Reaction time mean0.91.44.81.31.50.91.20.81.50.91.00.80.80.81.01.00.90.72.10.30.52.2
Reaction time mean AUC1.11.85.61.51.71.11.51.01.71.11.21.01.01.11.21.21.10.82.30.40.72.4
Median of all reaction times0.81.25.61.41.50.81.10.71.30.80.80.70.70.70.60.90.50.32.2-0.1-0.12.4
Reaction time omissions0.10.20.7-0.7-0.1-0.6-0.4-0.50.3-0.5-0.4-0.4-0.4-0.80.5-0.40.10.20.20.10.70.3
Reaction time false alarm rate0.10.10.90.3-0.2-0.1-0.5-0.10.4-0.30.0-0.2-0.2-1.00.2-0.3-0.40.20.20.30.00.1
Reaction time premature initiation rate4.66.314.7-3.0-2.6-2.9-3.0-3.0-1.8-2.9-3.0-3.0-3.0-3.8-1.7-3.0-2.1-1.6-1.5-0.9-1.3-1.2
Reaction time premature initiations3.56.310.9-3.1-2.7-2.9-2.9-3.0-2.1-2.8-3.0-3.0-3.0-3.3-1.9-2.9-1.9-1.8-1.6-1.2-1.2-1.5
Std. dev. reaction times1.01.93.71.01.51.01.30.91.91.11.31.11.10.71.91.21.61.51.61.21.61.6
Reaction time trials completed0.61.12.2-1.4-1.3-1.2-1.0-1.1-1.5-1.1-1.2-1.0-1.0-0.4-1.1-1.0-0.7-1.2-1.1-1.1-0.3-1.1
Reaction time trials AUC0.81.62.8-1.6-1.4-1.4-1.2-1.4-1.7-1.2-1.4-1.2-1.2-0.5-1.3-1.2-0.9-1.4-1.2-1.3-0.5-1.1
Run reversals in cocaine runway, females1.51.52.9-1.4-1.3-1.3-1.5-1.4-0.9-1.6-1.3-1.3-1.3-1.7-0.8-1.4-1.2-0.9-1.1-0.8-0.7-0.3
Run reversals in cocaine runway, males1.71.72.2-1.5-1.4-1.5-1.4-1.4-1.4-1.3-1.5-1.4-1.4-1.3-1.3-1.4-1.2-1.1-1.3-0.9-1.0-0.8
Latency to leave start box in cocaine runway5.66.48.62.12.42.82.82.92.42.62.52.72.72.92.82.72.92.71.52.52.40.9
Latency to leave start box in cocaine runway, F4.55.27.01.91.92.52.42.52.12.42.32.52.52.42.52.32.62.61.02.62.30.1
Latency to leave start box in cocaine runway, M1.00.91.80.61.01.11.11.10.81.00.91.01.01.21.11.01.30.90.50.71.00.8
Std. dev. time between licks in bursts1.72.45.7-0.6-0.6-1.4-1.1-1.4-1.0-1.5-1.5-1.5-1.5-1.2-1.7-1.4-1.9-2.10.7-2.4-2.21.7
Total sessions with >9 infusions0.10.21.40.30.40.20.30.10.60.20.20.30.30.10.50.20.30.10.6-0.20.11.2
Short access day 1 total inactive lever presses0.91.11.91.21.11.00.91.11.41.10.91.01.00.31.40.91.01.40.71.41.20.6
Short access day 10 total inactive lever presses0.10.10.90.40.50.10.10.10.50.20.10.10.1-0.5-0.00.1-0.0-0.00.80.1-0.31.0
Short access day 1 total infusions0.50.71.50.80.90.60.70.71.20.80.80.90.90.41.20.70.90.90.80.70.91.0
Short access day 10 total infusions0.20.30.70.40.60.40.50.40.80.50.50.60.60.20.70.50.60.50.50.20.50.9
Short access total infusions0.50.71.20.70.90.80.80.71.10.80.80.90.90.61.10.80.90.80.60.50.91.0
Short access day 1 locomotion2.02.57.92.32.11.41.71.41.71.51.41.51.51.10.81.40.70.52.60.1-0.42.8
Short access day 10 total locomotion0.40.84.70.20.2-0.5-0.3-0.50.1-0.6-0.5-0.5-0.5-0.8-0.8-0.4-1.0-1.31.0-1.6-1.42.2
Short access total locomotion0.70.97.41.01.00.30.50.20.60.20.20.30.30.1-0.20.3-0.2-0.61.7-1.0-1.22.7
One hour access (0.3 mA shock)0.10.11.00.00.10.20.40.3-0.30.10.10.20.21.0-0.10.40.3-0.3-0.2-0.60.00.1
Compulsive drug intake1.51.73.11.11.11.31.21.21.71.11.31.21.20.61.81.11.41.71.41.71.80.5
One hour access (shock baseline)0.20.31.1-0.6-0.5-0.5-0.3-0.4-0.9-0.4-0.5-0.4-0.40.4-0.7-0.3-0.3-0.8-0.8-1.0-0.6-0.3
Social response proportion3.33.85.01.71.72.12.02.02.02.02.02.12.11.82.21.92.12.21.42.12.20.4
Social responses0.70.91.60.80.90.91.00.91.20.90.90.90.90.71.20.81.11.01.10.91.20.8
Social time2.12.95.41.51.71.91.91.91.61.81.81.81.82.31.81.91.81.61.01.21.60.8
Soleus weight0.41.36.6-1.6-1.6-0.8-0.8-0.7-1.5-0.9-0.6-0.6-0.60.2-0.7-0.6-0.4-0.4-2.3-0.20.5-2.6
Bone: stiffness0.30.51.5-1.2-0.7-0.6-0.6-0.60.1-0.7-0.8-0.6-0.6-1.00.5-0.60.30.4-0.50.60.9-0.6
Tibialis anterior weight0.10.20.8-0.1-0.2-0.5-0.5-0.4-0.5-0.4-0.3-0.3-0.3-0.5-0.8-0.3-0.6-0.8-0.4-0.9-0.70.1
Time to tail flick, vehicle, before self-admin0.40.40.6-0.7-0.6-0.8-0.6-0.7-0.8-0.6-0.6-0.6-0.6-0.3-0.6-0.6-0.5-0.7-0.6-0.7-0.6-0.1
Time to tail flick, vehicle, after self-admin0.81.14.4-1.7-1.2-0.9-1.1-0.9-1.0-0.8-0.7-0.8-0.8-0.7-0.4-0.8-0.2-0.2-2.10.00.4-1.9
Time to tail flick, test, before self-admin0.20.20.6-0.30.30.40.30.50.40.40.50.50.50.50.70.50.70.6-0.60.40.6-0.3
Time to tail flick, test, after self-admin0.10.10.5-0.30.2-0.10.00.0-0.30.1-0.0-0.0-0.00.50.00.20.4-0.1-0.7-0.3-0.0-0.3
Delta time to tail flick, vehicle, before/after SA0.70.73.2-0.7-0.30.2-0.10.10.20.20.20.20.2-0.00.90.20.81.0-1.31.21.6-1.8
Delta time to tail flick, test, before/after SA1.11.12.1-0.6-0.8-1.1-1.0-1.2-1.3-0.9-1.2-1.2-1.2-0.7-1.4-1.0-1.2-1.3-0.7-1.2-1.1-0.3
Tibia length6.116.820.6-4.3-4.5-4.5-4.4-4.5-4.5-4.4-4.3-4.4-4.4-3.8-4.0-4.5-3.9-3.7-3.7-3.3-3.2-2.6
Ambulatory time before self-admin0.40.61.8-0.2-0.8-0.5-0.5-0.5-1.0-0.7-0.4-0.5-0.5-0.2-1.3-0.6-1.2-1.1-0.4-1.2-1.40.0
Ambulatory time after self-admin1.01.23.4-0.6-0.8-0.9-0.8-0.9-1.2-1.1-0.8-0.8-0.8-0.5-1.5-0.9-1.4-1.7-0.5-1.8-1.70.3
Bone: tissue strength2.52.64.8-1.8-1.9-1.6-1.8-1.7-1.8-1.5-1.6-1.5-1.5-1.5-1.4-1.6-1.5-1.2-2.2-0.9-0.8-1.9
Total heroin consumption0.20.20.5-0.7-0.3-0.6-0.5-0.6-0.2-0.6-0.7-0.7-0.7-0.7-0.1-0.6-0.2-0.2-0.1-0.2-0.20.0
Bone: trabecular number1.01.77.5-0.10.10.80.30.81.40.80.70.70.7-0.42.00.51.62.3-0.42.72.4-1.4
Bone: trabecular spacing0.71.04.90.60.0-0.10.3-0.0-1.2-0.2-0.0-0.1-0.11.4-1.60.2-1.2-1.80.3-2.2-1.40.8
Bone: trabecular thickness0.40.62.3-0.4-0.4-0.1-0.5-0.10.8-0.1-0.3-0.1-0.1-1.31.1-0.30.51.1-0.01.51.4-0.5
Bone: trabecular tissue density0.50.73.51.11.10.60.80.61.10.40.60.60.60.20.50.60.40.31.60.0-0.21.9
Water consumed over 24 hours0.10.20.7-0.3-0.3-0.3-0.1-0.3-0.7-0.1-0.4-0.4-0.40.0-0.8-0.3-0.6-0.60.0-0.4-0.6-0.1
Number of responses in last shaping day1.41.56.81.91.60.91.11.01.21.11.11.01.00.70.30.90.2-0.02.2-0.5-0.72.6