Rac3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	mRNA stability	Rac3	0.06	0.04	1.1e-04	0.03	0.04	0.03	0.03	3.3e-04	4.7e-05	5.6e-04	1.3e-04
2	Brain	mRNA stability	Rac3	0.1	0.07	1.1e-08	0.06	0.09	0.09	0.09	3.7e-06	6.2e-09	7.2e-09	9.1e-09
3	Liver	mRNA stability	Rac3	0.03	0.02	2.7e-03	0.02	0.01	0	0.01	1.7e-03	1.4e-02	1.4e-01	1.6e-02
4	Liver	gene expression	Rac3	0.46	0.12	0.0e+00	0.51	0.51	0.51	0.51	2.1e-65	3.8e-65	1.4e-65	4.6e-65
5	NAcc	mRNA stability	Rac3	0.03	0.02	1.2e-03	0.03	0.02	0.02	0.03	5.9e-04	2.3e-03	3.1e-03	5.9e-04
6	Adipose	gene expression	Rac3	0.08	0.06	6.6e-07	0.06	0.06	0.05	0.06	3.2e-07	3.4e-07	1.4e-06	7.2e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.0	0.1	0.3	-0.1	-0.1	-0.1	0.2	-0.3	-0.5
Area under the delay curve	1.3	1.4	2.6	1.2	1.2	-1.1	1.0	-0.8	1.6
BMI with tail	0.5	1.6	6.4	-1.2	-1.2	0.3	-0.3	0.2	2.5
BMI without tail	1.1	2.2	5.7	-1.7	-2.0	0.5	-0.6	0.5	-2.4
Body weight	2.0	8.3	15.3	-3.9	-3.9	2.6	-2.6	2.3	0.8
Weight adjusted by age	2.1	2.4	3.3	-1.8	-1.8	1.6	-1.6	1.4	-1.0
Bone surface	0.3	0.4	1.7	-0.5	-0.4	0.6	-0.3	0.3	-1.3
Bone volume	0.2	0.3	1.3	-0.4	-0.4	0.4	-0.2	0.1	-1.2
Breakpoint value in progressive ratio session	1.4	1.5	2.0	-1.3	-1.1	1.4	-1.4	1.4	0.5
Number of licking bursts	0.1	0.1	0.3	0.2	0.1	-0.4	0.4	-0.5	-0.2
Context. condit. distance diff. score	0.5	0.6	1.3	0.4	0.4	-1.1	0.8	-0.9	-0.8
Locomotion velocity, session 1	0.3	0.3	1.3	0.6	0.6	-0.0	-0.1	0.1	1.1
Locomotion distance, session 1	3.5	4.5	4.9	2.2	2.1	-2.1	2.2	-2.2	1.9
Locomotion velocity, session 2	2.7	3.1	5.4	1.9	2.0	-1.4	1.5	-1.4	2.3
Locomotion distance, session 2	1.2	1.6	1.9	1.2	1.1	-1.3	1.3	-1.4	1.4
Locomotion velocity, session 3	0.7	0.9	2.9	0.8	0.9	-0.4	0.6	-0.5	1.7
Locomotion distance, session 3	2.4	2.6	5.6	1.6	1.6	-1.2	1.4	-1.3	2.4
Stereotopy head waving bouts, day 3	0.1	0.2	0.8	0.3	0.3	-0.0	0.1	-0.1	0.9
Stereotopy head waving duration, day 3	0.1	0.2	0.6	0.4	0.4	-0.2	0.3	-0.2	0.7
Locomotion velocity, session 7	0.7	0.8	1.0	1.0	1.0	-0.8	0.9	-0.9	0.6
Locomotion distance, session 7	4.1	5.2	6.1	2.5	2.4	-2.4	2.4	-2.3	1.4
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	-0.4	-0.4	0.2	-0.2	0.2	0.3
Stereotopy head waving duration, day 7	0.3	0.3	0.5	-0.7	-0.7	0.6	-0.5	0.5	0.0
Locomotion velocity, session 8	1.6	2.0	2.6	1.3	1.1	-1.6	1.4	-1.4	1.5
Locomotion distance, session 8	1.8	2.6	4.6	1.4	1.2	-2.1	1.9	-2.0	0.4
Degree of sensitization distance	0.4	0.4	2.1	0.0	-0.1	-0.4	0.1	-0.1	-1.4
Degree of sensitization stereotypy	0.2	0.2	0.4	-0.6	-0.6	0.3	-0.3	0.3	0.1
Conditioned locomotion	1.3	1.5	2.8	-1.4	-1.5	0.7	-0.8	0.7	-1.7
Cocaine response after cond. corrected	0.1	0.2	0.3	-0.3	-0.3	0.5	-0.4	0.4	0.5
Cocaine response after cond. not corrected	0.1	0.2	0.7	0.3	0.3	-0.0	0.1	-0.1	0.8
Cocaine response before conditioning	1.3	1.6	1.8	1.3	1.3	-1.2	1.4	-1.4	1.0
Saline control response	1.6	2.1	3.0	-1.7	-1.7	1.3	-1.3	1.2	-1.4
Bone: connectivity density	0.4	0.6	0.8	0.7	0.7	-0.9	0.9	-0.9	-0.7
Bone: cortical apparent density	1.1	1.5	2.3	1.4	1.5	-0.9	1.1	-1.0	1.3
Bone: cortical area	5.4	8.1	13.5	-3.6	-3.7	2.7	-2.4	2.2	2.0
Bone: cortical porosity	3.7	4.0	5.8	-2.1	-2.0	2.4	-2.3	2.2	-0.1
Bone: cortical porosity	3.3	3.6	5.0	-2.0	-1.9	2.2	-2.1	2.0	-0.5
Bone: cortical thickness	6.9	11.3	16.4	-4.0	-4.0	3.2	-2.9	2.6	3.2
Bone: cortical thickness	2.9	3.3	5.6	-2.0	-2.1	1.5	-1.4	1.3	2.4
Bone: cortical tissue density	1.3	1.7	2.8	1.6	1.7	-1.0	1.1	-1.1	1.1
Condit. Reinf. active minus inactive responses	1.2	1.3	2.1	-1.3	-1.4	0.8	-1.0	0.9	-1.1
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.0	-1.0	-1.0	0.6	-0.6	0.6	-0.2
Condit. Reinf. active responses	2.0	2.4	3.6	-1.7	-1.9	1.1	-1.4	1.2	-1.8
Condit. Reinf. inactive responses	0.7	0.8	2.4	-0.8	-0.9	0.5	-0.7	0.6	-1.5
Incentive salience index mean	0.7	0.8	1.5	-1.0	-1.1	0.6	-0.7	0.6	-1.2
Condit. Reinf. lever presses	0.3	0.4	0.6	0.5	0.5	-0.6	0.7	-0.8	-0.4
Condit. Reinf. active minus inactive responses	0.4	0.5	1.1	-0.9	-1.1	0.3	-0.7	0.7	0.3
Condit. Reinf. active-inactive response ratio	2.2	2.3	3.6	-1.7	-1.9	1.3	-1.6	1.6	-0.5
Condit. Reinf. active responses	0.1	0.1	0.2	-0.3	-0.4	-0.2	-0.2	0.2	0.5
Condit. Reinf. inactive responses	0.7	0.8	1.2	0.9	0.9	-1.0	0.8	-0.7	1.1
Condit. Reinf. lever presses	0.0	0.0	0.1	0.1	-0.1	-0.4	0.2	-0.2	-0.1
Condit. Reinf. lever reinforcers received	0.0	0.1	0.2	-0.1	-0.3	-0.4	-0.0	0.1	0.4
Conditioned reinforcement - actives	0.3	0.3	0.6	0.5	0.5	-0.8	0.7	-0.8	-0.1
Conditioned reinforcement - inactives	1.1	1.3	1.7	-1.2	-1.3	1.1	-1.2	1.1	-0.6
Conditioned locomotion	0.0	0.1	0.2	0.1	0.1	-0.2	0.2	-0.2	-0.4
Patch foraging indifference point 0 sec	0.1	0.1	0.2	-0.3	-0.3	0.5	-0.2	0.3	-0.2
Patch foraging indifference point AUC	0.2	0.2	1.0	0.2	0.1	-0.1	0.0	-0.0	-1.0
Delay disc. indifference point, 0s delay	0.2	0.3	1.4	0.1	0.1	-0.3	0.2	-0.2	1.2
Delay disc. indifference point, 16s delay	3.5	3.5	4.4	1.9	1.9	-2.1	2.0	-2.0	1.2
Delay disc. indifference point, 2s delay	0.2	0.2	0.6	0.4	0.4	-0.3	0.2	-0.1	0.7
Delay disc. indifference point, 24s delay	2.2	2.1	4.2	1.6	1.7	-1.1	1.0	-0.9	2.1
Delay disc. indifference point, 4s delay	0.4	0.4	1.7	0.5	0.4	-0.3	0.4	-0.4	1.3
Delay disc. indifference point, 8s delay	0.5	0.5	2.6	0.3	0.4	-0.2	0.0	0.2	1.6
Indifference point function ln k	1.3	1.8	6.2	0.9	1.0	-0.8	1.1	-1.0	2.5
Indifference point function log k	1.3	1.8	6.2	0.9	1.0	-0.8	1.1	-1.0	2.5
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	-0.2	-0.2	0.3	-0.1	0.2	-0.0
Patch foraging total patch changes 12 sec	0.2	0.2	0.5	-0.2	-0.3	0.6	-0.5	0.4	-0.7
Patch foraging total patch changes 18 sec	0.3	0.4	0.6	0.7	0.6	-0.6	0.8	-0.6	-0.3
Patch foraging total patch changes 24 sec	0.3	0.3	0.5	-0.6	-0.6	0.5	-0.4	0.4	-0.7
Patch foraging total patch changes 6 sec	0.5	0.8	1.1	-0.8	-0.8	1.1	-0.8	0.8	-1.0
Patch foraging time to switch 0 sec	0.2	0.3	0.6	0.7	0.8	-0.4	0.5	-0.6	0.1
Patch foraging water rate 0 sec	0.7	1.1	2.1	-1.4	-1.5	0.7	-0.9	1.0	-0.7
Patch foraging water rate 12 sec	0.2	0.4	1.6	-0.1	-0.1	-0.7	0.4	-0.3	1.3
Patch foraging water rate 18 sec	0.2	0.2	0.5	-0.1	-0.2	-0.5	0.5	-0.6	0.7
Patch foraging water rate 24 sec	0.1	0.2	0.5	-0.6	-0.7	-0.5	0.1	-0.1	0.0
Patch foraging water rate 6 sec	0.5	0.8	4.2	-0.1	-0.1	-0.5	0.4	-0.4	2.0
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	1.3	-1.1	-1.2	0.7	-0.8	0.8	-0.6
Distance traveled before self-admin	2.5	2.7	3.6	-1.8	-1.6	1.9	-1.8	1.7	-0.7
Distance traveled after self-admin	1.0	1.1	6.7	-0.1	-0.1	0.1	-0.1	-0.1	-2.6
Extensor digitorum longus weight	0.2	0.8	1.5	0.7	0.6	-1.1	1.2	-1.2	0.2
Bone: elastic displacement	1.5	1.7	2.5	-1.6	-1.6	1.5	-1.2	1.2	-0.1
Bone: elastic work	9.5	12.3	17.3	-4.2	-4.2	3.9	-3.5	3.4	-0.0
Bone: endosteal estimation	0.3	0.6	0.8	0.7	0.7	-0.9	0.8	-0.8	-0.8
Bone: endosteal perimeter	0.5	1.0	2.2	-1.0	-0.9	1.0	-0.8	0.7	-1.5
Epididymis fat weight	0.2	0.4	1.0	-1.0	-0.9	0.3	-0.4	0.4	-0.2
Delta time in closed arm before/after self-admin	0.4	0.4	0.5	0.6	0.5	-0.7	0.7	-0.6	0.4
Delta time in open arm before/after self-admin	0.0	0.0	0.1	0.0	0.2	-0.2	0.2	-0.2	-0.2
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	0.2	0.5	-0.1	0.1	-0.0	0.3
Delay discount exponential model param	1.4	1.5	3.2	-1.3	-1.2	1.0	-0.9	0.8	-1.8
Extinction: sum of active levers before priming	0.6	0.6	2.3	0.5	0.8	-0.3	0.3	-0.4	1.5
Active lever presses in extinction session 6	1.0	1.0	3.9	-0.5	-0.3	0.8	-0.7	0.6	2.0
Bone: final force	4.7	7.5	12.7	-3.4	-3.6	2.5	-2.3	2.2	2.0
Bone: final moment	5.6	9.0	15.1	-3.8	-3.9	2.9	-2.7	2.5	1.7
Food consumed during 24 hour testing period	0.3	0.4	1.6	-0.4	-0.4	0.3	-0.4	0.2	-1.3
Glucose	0.8	1.1	3.0	-0.1	0.1	0.9	-1.1	1.3	1.7
Heart weight	0.5	0.7	1.2	-1.1	-1.1	0.6	-0.8	0.8	0.7
Delay discount hyperbolic model param	1.4	1.5	3.1	-1.3	-1.2	1.0	-0.9	0.8	-1.7
Intermittent access intake day 1-15 change	1.4	1.3	3.2	-0.9	-0.9	1.1	-1.0	1.0	-1.8
Intermittent access intake escalation	1.0	0.9	3.3	-0.6	-0.7	0.8	-0.7	0.7	-1.8
Intermittent access intake escalation 2	3.5	3.5	4.0	-1.8	-1.7	2.0	-2.0	2.0	-1.6
Intermitt. access day 1 inactive lever presses	1.4	1.5	2.0	-1.3	-1.3	1.4	-1.3	1.3	-0.5
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.6	-0.5	-0.6	0.1	-0.2	0.2	-0.8
Intermitt. access escalation Index	0.5	0.5	2.1	0.1	-0.0	-0.6	0.4	-0.5	-1.5
Intermittent access day 1 total infusions	0.1	0.1	0.3	-0.5	-0.6	0.3	-0.3	0.3	-0.0
Intermittent access day 15 total infusions	0.4	0.5	1.6	-0.5	-0.6	0.4	-0.4	0.4	-1.2
Intermittent access terminal intake (last 3 days)	1.1	1.2	2.9	-1.0	-1.0	0.8	-0.9	0.9	-1.7
Intermittent access total infusions	0.2	0.2	0.5	-0.5	-0.6	0.3	-0.3	0.3	-0.7
Intermittent access day 1 locomotion	0.1	0.1	0.3	-0.2	-0.3	-0.1	0.1	-0.1	0.5
Intermittent access day 15 total locomotion	0.4	0.4	0.5	-0.7	-0.7	0.7	-0.7	0.6	-0.6
Intermittent access total locomotion	0.2	0.2	0.4	-0.6	-0.6	0.4	-0.4	0.4	0.1
Intermittent access standard deviation	0.8	0.8	1.2	-0.6	-0.4	1.1	-1.0	1.1	1.0
Left kidney weight	0.4	1.1	4.0	-0.9	-0.9	0.8	-0.6	0.4	2.0
Right kidney weight	0.3	0.9	5.3	-0.3	-0.3	-0.0	-0.0	-0.1	2.3
Cocaine induced anxiety	8.2	9.4	11.9	-3.4	-3.2	3.4	-3.4	3.4	-0.3
Post-drug Anxiety	2.0	2.2	2.9	-1.5	-1.4	1.7	-1.6	1.7	0.6
Baseline Anxiety	8.0	8.5	10.4	3.2	3.1	-3.1	3.0	-3.0	2.0
Tail length	2.5	7.5	20.6	-2.6	-2.9	1.8	-1.8	1.7	-4.5
Length with tail	1.7	6.4	9.7	-3.1	-3.1	2.6	-2.4	2.3	-0.9
Length without tail	1.8	3.9	15.1	-1.3	-1.0	1.5	-1.3	1.3	3.9
Times rat made contact with spout	3.4	4.0	9.7	-1.4	-1.4	1.9	-1.8	1.8	-3.1
Lifetime Intake	0.0	0.0	0.2	-0.2	-0.2	0.1	-0.1	0.1	-0.4
Liver weight, left	0.4	0.6	1.0	-0.7	-0.5	0.9	-0.9	1.0	0.7
Liver weight, right	1.1	1.8	3.0	-1.7	-1.7	1.4	-1.3	1.1	-0.1
Locomotor activity	0.4	0.6	1.0	0.8	0.9	-0.6	0.7	-0.7	1.0
Locomotor testing distance	1.1	1.8	2.1	1.4	1.5	-1.3	1.4	-1.4	1.2
Locomotor testing rearing	0.6	0.9	1.3	1.1	1.1	-1.0	1.0	-1.0	-0.4
Locomotion in novel chamber	0.4	0.5	1.0	0.7	0.8	-1.0	0.7	-0.5	0.5
Locomotion in novel chamber post-restriction	1.9	2.3	3.3	-1.5	-1.6	1.4	-1.3	1.4	-1.8
Fecal boli incidents, locomotor time 1	0.7	0.8	1.0	1.0	1.0	-0.9	0.9	-1.0	0.2
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	0.3	0.4	0.5	-0.3	0.3	0.6
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.7	0.2	0.1	-0.7	0.5	-0.2	-0.8
Bouts of movement, locomotor time 1	0.8	0.9	1.4	1.1	1.2	-0.8	0.9	-0.6	1.0
Total resting periods, locomotor time 1	0.7	0.8	1.3	1.1	1.1	-0.6	0.8	-0.5	1.0
Rest time, locomotor task time 1	0.0	0.1	0.2	0.0	0.0	0.4	-0.3	0.3	0.1
Distance moved, locomotor task time 1	0.0	0.0	0.2	-0.4	-0.3	0.0	-0.0	0.0	-0.0
Vertical activity count, locomotor time 1	0.1	0.1	0.2	-0.4	-0.2	-0.4	0.2	-0.3	-0.2
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.0	-0.1	-0.3	0.1	0.2	0.4
Bouts of movement, locomotor time 2	1.1	1.2	1.4	1.2	1.2	-1.2	1.1	-0.6	1.1
Total resting periods, locomotor time 2	1.2	1.3	1.8	1.2	1.2	-1.3	1.3	-0.8	0.8
Rest time, locomotor task time 2	0.2	0.2	0.8	0.3	0.4	-0.2	0.2	-0.2	-0.9
Distance moved, locomotor task time 2	0.3	0.3	1.8	-0.2	-0.2	-0.1	0.1	0.0	1.3
Vertical activity count, locomotor time 2	0.6	0.7	2.2	0.2	0.2	-0.9	0.7	-0.7	1.5
Light reinforcement 1	0.2	0.4	1.8	-0.4	-0.3	-0.4	0.1	-0.2	-1.3
Light reinforcement 2	0.5	0.6	1.3	-1.1	-1.0	0.5	-0.5	0.5	-0.8
Bone: marrow area	0.3	0.6	0.8	0.7	0.7	-0.9	0.8	-0.8	-0.8
Bone: maximum diameter	0.9	1.7	3.0	-1.7	-1.7	1.3	-1.0	1.0	0.7
Bone: maximum force	4.2	7.3	12.9	-3.4	-3.6	2.3	-2.3	2.2	1.8
Bone: maximum moment	5.0	8.7	15.1	-3.7	-3.9	2.7	-2.7	2.5	1.5
Mean time between licks in bursts	1.4	2.0	2.5	1.6	1.5	-1.3	1.4	-1.4	1.1
Mean num. licks in bursts	1.4	1.6	2.7	-0.9	-0.9	1.3	-1.3	1.4	-1.6
Cd content in liver	1.7	1.9	3.0	1.4	1.3	-1.3	1.2	-1.2	1.7
Co content in liver	0.2	0.2	0.4	0.5	0.6	-0.2	0.5	-0.6	-0.1
Cu content in liver	1.0	1.2	1.8	-1.2	-1.1	1.4	-1.1	1.3	-0.0
Fe content in liver	0.9	1.1	1.7	1.3	1.3	-1.0	1.1	-1.0	0.2
K content in liver	0.6	0.5	2.7	-0.5	-0.6	0.1	-0.0	-0.0	-1.6
Mg content in liver	1.2	1.2	1.8	0.9	0.8	-1.4	1.2	-1.2	-1.0
Mn content in liver	0.2	0.2	0.4	-0.6	-0.6	0.4	-0.5	0.5	0.3
Na content in liver	0.0	0.0	0.3	-0.0	0.1	0.0	0.0	-0.0	-0.5
Rb content in liver	0.1	0.2	0.3	-0.4	-0.5	-0.4	-0.0	0.1	-0.6
Se content in liver	0.5	0.6	3.4	-0.2	-0.3	0.1	-0.2	0.2	-1.8
Sr content in liver	1.0	0.9	1.6	-0.7	-0.6	1.2	-1.2	1.3	-0.2
Zn content in liver	0.0	0.0	0.0	0.2	0.1	-0.1	0.1	-0.2	0.2
Bone: minimum diameter	2.2	4.2	6.8	-2.6	-2.6	2.3	-1.9	1.6	-0.4
Time in familiar zone, hab. session 1	0.2	0.2	0.3	-0.3	-0.4	0.3	-0.5	0.5	0.3
Time in novel zone, hab. session 1	0.1	0.1	0.1	0.2	0.3	-0.2	0.3	-0.3	-0.2
Total zone transitions, hab. session 1	0.4	0.6	0.7	0.8	0.7	-0.8	0.8	-0.8	0.9
Total locomotion distance, hab. session 1	0.1	0.2	0.4	0.2	0.2	-0.4	0.5	-0.6	0.4
Locomotion velocity, hab. session 1	0.1	0.2	0.4	0.2	0.2	-0.4	0.6	-0.7	0.2
Time in familiar zone, hab. session 2	0.3	0.3	0.5	0.7	0.7	-0.6	0.6	-0.6	0.1
Time in novel zone, hab. session 2	0.1	0.1	0.3	0.1	0.0	-0.2	0.1	-0.0	0.6
Total zone transitions, hab. session 2	1.5	2.0	3.0	1.4	1.2	-1.7	1.6	-1.7	0.5
Total locomotion distance, hab. session 2	0.6	0.8	1.6	0.6	0.5	-1.2	1.1	-1.3	-0.1
Locomotion velocity, hab. session 2	0.4	0.5	1.1	0.4	0.2	-0.9	0.9	-1.0	-0.1
Novel to familiar place preference ratio	4.0	4.1	5.4	-2.3	-2.3	2.1	-2.2	2.1	-0.5
Novelty place preference	4.0	4.1	5.4	-2.3	-2.3	2.1	-2.2	2.2	-0.4
Time in novel zone, NPP test	3.1	3.1	4.2	-2.0	-2.0	1.8	-1.9	1.9	-0.3
Total zone transitions, NPP test	2.6	3.6	5.0	1.9	1.7	-2.2	2.2	-2.2	0.6
Total locomotion distance, NPP test	1.6	2.2	3.5	1.3	1.2	-1.9	1.8	-1.9	0.2
Locomotion velocity, NPP test	0.8	1.1	2.0	0.9	0.7	-1.4	1.3	-1.4	0.1
Intraocular pressure	0.3	0.4	1.3	-0.4	-0.6	0.2	-0.4	0.4	-1.1
Delta distance traveled before/after self-admin	1.8	2.0	2.4	1.4	1.3	-1.5	1.5	-1.5	-1.2
Delta ambulatory time before/after self-admin	2.9	3.2	4.0	2.0	1.8	-1.9	1.9	-1.9	-1.0
Parametrial fat weight	1.1	2.2	2.8	-1.6	-1.6	1.4	-1.3	1.2	-1.7
Pavlov. Cond. lever latency	2.2	2.8	4.0	1.7	1.6	-2.0	1.8	-1.8	1.0
Pavlov. Cond. magazine entry latency	4.1	5.2	6.3	-2.4	-2.3	2.5	-2.4	2.3	-1.6
Pavlov. Cond. change in total contacts	1.5	1.6	2.7	-1.3	-1.2	1.7	-1.4	1.4	-0.3
Pavlov. Cond. index score	3.9	4.9	5.7	-2.4	-2.3	2.4	-2.3	2.2	-1.7
Pavlov. Cond. latency score	3.6	4.6	5.6	-2.2	-2.2	2.4	-2.2	2.1	-1.6
Pavlov. Cond. lever contacts	1.1	1.3	1.8	-1.2	-1.1	1.4	-1.2	1.1	-0.9
Pavlov. Cond. magazine entry number	4.9	6.1	7.6	2.5	2.4	-2.8	2.7	-2.7	1.6
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.3	0.2	0.1	-0.6	0.4	-0.4	-0.5
Pavlov. Cond. lever-magazine prob. diff.	4.1	5.0	6.0	-2.5	-2.4	2.5	-2.3	2.2	-1.5
Pavlov. Cond. response bias	3.9	4.7	6.2	-2.3	-2.2	2.5	-2.3	2.3	-1.2
Pavlov. Cond. lever latency	0.2	0.2	1.2	0.0	0.1	0.4	-0.2	0.2	1.1
Pavlov. Cond. magazine entry latency	2.7	3.1	3.9	2.0	1.9	-1.9	1.9	-1.9	0.4
Pavlov. Cond. change in total contacts	0.5	0.7	1.1	0.9	0.9	-1.1	1.0	-0.9	0.1
Pavlov. Cond. index score	0.6	0.8	1.0	0.9	0.9	-1.0	1.0	-1.0	-0.4
Pavlov. Cond. latency score	0.7	0.9	1.1	0.9	0.9	-1.1	1.0	-1.1	-0.5
Pavlov. Cond. lever contacts	0.3	0.4	2.2	-0.1	-0.2	-0.4	0.2	-0.2	-1.5
Pavlov. Cond. magazine entry number	2.2	2.7	3.3	-1.8	-1.8	1.7	-1.8	1.8	-0.4
Pavlov. Cond. intertrial magazine entries	0.9	1.2	2.0	-1.3	-1.4	0.7	-1.1	1.1	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.0	1.2	1.0	1.0	-1.1	1.1	-1.1	-0.4
Pavlov. Cond. response bias	0.3	0.4	0.7	0.5	0.4	-0.8	0.6	-0.6	-0.5
Time in closed arm before self-admin	0.4	0.5	0.7	-0.6	-0.5	0.8	-0.7	0.8	0.6
Time in closed arm after self-admin	0.5	0.5	1.1	-0.3	-0.2	0.8	-0.7	0.9	1.0
Time in open arm before self-admin	0.6	0.7	1.0	0.9	0.8	-1.0	0.9	-1.0	0.2
Time in open arm after self-admin	0.6	0.6	1.0	0.7	0.7	-1.0	0.9	-1.0	0.3
Bone: periosteal estimation	1.0	2.0	3.9	-1.9	-2.0	1.3	-1.1	1.0	0.6
Bone: periosteal perimeter	3.6	6.1	8.9	-3.0	-2.9	2.7	-2.4	2.3	0.1
Bone: post-yield work	0.3	0.4	0.6	0.5	0.4	-0.8	0.6	-0.6	0.6
Progressive ratio test 1 active lever presses	0.6	0.6	1.7	-0.8	-0.7	0.5	-0.5	0.5	-1.3
Progressive ratio test 1 breakpoint	0.9	0.9	2.5	-0.9	-0.9	0.6	-0.6	0.7	-1.6
Progressive ratio test 1 inactive lever presses	0.9	1.0	1.7	-1.3	-1.3	0.8	-0.8	0.8	-0.8
Progressive ratio test 2 active lever presses	0.3	0.4	0.9	-0.5	-0.6	0.4	-0.5	0.5	-0.9
Progressive ratio test 2 breakpoint	0.2	0.3	1.0	-0.3	-0.5	0.2	-0.3	0.2	-1.0
Progressive ratio test 2 inactive lever presses	0.4	0.5	0.7	-0.8	-0.8	0.7	-0.8	0.7	-0.3
Incentive Sensitization - Responses	0.3	0.3	1.3	-0.3	-0.5	0.4	-0.4	0.3	-1.2
Incentive Sensitization - Breakpoint	0.3	0.3	1.2	-0.3	-0.4	0.4	-0.4	0.4	-1.1
Sum of active levers in priming session hrs 5-6	1.8	1.8	2.3	-1.4	-1.3	1.5	-1.5	1.5	-0.3
Progressive ratio	0.3	0.3	0.4	0.7	0.6	-0.5	0.5	-0.5	0.7
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.1	0.0	0.4	-0.4	0.5	-0.3
Seeking ratio, punishment vs. effort	0.1	0.1	0.4	-0.3	-0.3	0.2	-0.2	0.3	-0.6
Retroperitoneal fat weight	2.4	7.8	10.7	-3.3	-3.1	2.4	-2.4	2.2	-3.2
Reaction time number correct	2.6	3.7	6.8	1.6	1.5	-2.6	2.3	-2.3	-0.1
Reaction time mean minus median	0.2	0.3	0.5	-0.3	-0.0	0.6	-0.5	0.6	-0.7
Reaction time mean minus median AUC	0.0	0.1	0.1	-0.2	-0.0	0.2	-0.2	0.3	-0.4
Reaction time num false alarms	0.1	0.2	0.3	0.5	0.5	-0.4	0.4	-0.4	-0.2
Reaction time num false alarms AUC	0.5	0.7	1.1	1.0	1.0	-0.9	0.9	-0.9	0.0
Reaction time trials correct on left	2.6	3.7	6.8	1.6	1.5	-2.6	2.3	-2.3	-0.1
Reaction time trials on left	2.7	3.9	7.0	1.6	1.5	-2.7	2.4	-2.4	-0.1
Reaction time mean	0.2	0.2	0.9	-0.4	-0.3	0.2	-0.3	0.4	-0.9
Reaction time mean AUC	0.1	0.1	0.7	-0.1	-0.0	-0.2	0.2	-0.1	-0.8
Median of all reaction times	0.1	0.1	0.3	-0.3	-0.3	-0.0	-0.1	0.1	-0.5
Reaction time omissions	0.2	0.3	1.2	0.2	0.3	-0.3	0.4	-0.4	-1.1
Reaction time false alarm rate	0.1	0.1	0.3	0.1	0.1	0.5	-0.4	0.3	-0.1
Reaction time premature initiation rate	0.6	0.8	1.5	1.2	1.1	-0.8	0.8	-0.8	0.1
Reaction time premature initiations	2.2	3.1	4.4	1.9	1.7	-2.1	1.9	-1.9	0.0
Std. dev. reaction times	0.2	0.3	0.6	0.6	0.7	-0.5	0.5	-0.3	-0.7
Reaction time trials completed	2.7	3.9	7.0	1.6	1.5	-2.7	2.4	-2.4	-0.1
Reaction time trials AUC	2.6	3.7	6.7	1.6	1.5	-2.6	2.3	-2.3	-0.1
Run reversals in cocaine runway, females	1.2	1.1	1.7	1.1	1.1	-1.3	1.1	-1.0	-0.4
Run reversals in cocaine runway, males	2.9	2.8	3.5	-1.6	-1.6	1.8	-1.9	1.8	-1.1
Latency to leave start box in cocaine runway	0.5	0.6	1.0	0.8	0.7	-0.7	1.0	-0.9	0.0
Latency to leave start box in cocaine runway, F	1.6	1.7	2.7	1.3	1.2	-1.4	1.6	-1.6	-0.2
Latency to leave start box in cocaine runway, M	0.2	0.2	0.3	-0.4	-0.4	0.6	-0.4	0.6	-0.1
Std. dev. time between licks in bursts	1.0	1.1	2.2	0.7	0.6	-1.5	1.4	-1.4	0.2
Total sessions with >9 infusions	0.4	0.5	0.7	0.6	0.6	-0.7	0.7	-0.7	0.8
Short access day 1 total inactive lever presses	0.8	0.9	1.4	0.8	0.7	-1.2	1.1	-1.2	0.2
Short access day 10 total inactive lever presses	2.9	3.2	4.8	-2.0	-2.2	1.9	-1.8	1.8	-0.7
Short access day 1 total infusions	1.2	1.2	1.7	1.1	1.3	-1.0	1.0	-1.0	1.3
Short access day 10 total infusions	0.6	0.7	0.8	-0.9	-0.8	0.9	-0.8	0.8	-0.8
Short access total infusions	0.0	0.0	0.0	0.0	0.0	-0.0	0.0	0.0	-0.1
Short access day 1 locomotion	0.3	0.3	1.6	0.2	0.3	0.0	0.0	-0.0	1.3
Short access day 10 total locomotion	0.4	0.4	0.9	-0.4	-0.4	0.7	-0.7	0.7	0.9
Short access total locomotion	0.2	0.3	1.5	0.1	0.2	0.1	-0.1	0.1	1.2
One hour access (0.3 mA shock)	0.7	0.8	2.3	-0.8	-1.0	0.5	-0.6	0.5	-1.5
Compulsive drug intake	0.1	0.1	0.2	-0.5	-0.5	0.2	-0.2	0.2	-0.1
One hour access (shock baseline)	0.1	0.2	0.8	0.1	0.0	-0.3	0.2	-0.3	-0.9
Social response proportion	1.0	1.1	2.9	0.8	0.7	-0.9	0.9	-0.9	1.7
Social responses	0.8	1.1	3.8	0.5	0.6	-0.6	0.9	-1.0	2.0
Social time	0.6	0.8	2.6	0.4	0.4	-0.6	0.8	-0.9	1.6
Soleus weight	0.6	1.8	2.7	-1.5	-1.6	1.1	-1.1	1.0	-1.6
Bone: stiffness	1.2	1.9	7.2	-1.2	-1.3	0.5	-0.6	0.5	2.7
Tibialis anterior weight	0.1	0.3	0.6	0.5	0.4	-0.5	0.6	-0.6	-0.8
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.9	-0.0	-0.0	-0.1	-0.0	-0.1	-1.0
Time to tail flick, vehicle, after self-admin	2.2	2.3	2.9	1.5	1.5	-1.4	1.5	-1.5	1.7
Time to tail flick, test, before self-admin	0.2	0.2	0.3	-0.3	-0.5	0.6	-0.5	0.6	-0.3
Time to tail flick, test, after self-admin	0.3	0.3	0.9	0.5	0.5	-0.3	0.4	-0.4	0.9
Delta time to tail flick, vehicle, before/after SA	1.0	1.0	1.4	1.0	0.9	-1.1	1.1	-1.2	0.6
Delta time to tail flick, test, before/after SA	0.5	0.4	2.5	0.2	0.3	-0.1	0.1	-0.1	1.6
Tibia length	9.0	25.4	39.3	-6.2	-6.3	5.1	-5.0	4.9	-0.1
Ambulatory time before self-admin	3.5	3.6	5.0	-2.2	-2.0	2.1	-2.0	2.0	-0.6
Ambulatory time after self-admin	0.5	0.6	3.4	-0.2	-0.2	0.2	-0.2	0.0	-1.8
Bone: tissue strength	0.3	0.3	0.6	-0.7	-0.8	0.2	-0.0	-0.0	0.7
Total heroin consumption	1.2	1.5	2.7	-1.1	-0.9	1.1	-1.2	1.2	1.7
Bone: trabecular number	0.1	0.1	0.8	0.1	0.1	-0.2	0.1	-0.1	-0.9
Bone: trabecular spacing	0.9	1.2	2.0	0.8	0.7	-1.4	1.4	-1.4	0.4
Bone: trabecular thickness	2.0	2.4	3.3	-1.6	-1.5	1.8	-1.7	1.7	-0.6
Bone: trabecular tissue density	0.6	0.9	1.8	0.9	1.0	-0.8	0.8	-0.6	1.4
Water consumed over 24 hours	0.2	0.3	0.5	-0.3	-0.2	0.7	-0.6	0.5	-0.6
Number of responses in last shaping day	0.3	0.3	0.6	-0.7	-0.7	0.2	-0.3	0.3	0.8