Rac3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	Rac3	0.07	0.04	6.9e-07	0.04	0.07	0.07	0.07	7.9e-05	3.8e-07	7.2e-07	7.6e-07
2	NAcc	mRNA stability	Rac3	0.02	0.02	3.9e-04	0.01	0.02	0.02	0.02	2.1e-02	2.7e-04	4.6e-04	8.4e-04
3	Adipose	gene expression	Rac3	0.06	0.04	6.8e-08	0.04	0.07	0.07	0.07	5.3e-05	3.5e-08	5.7e-08	4.1e-08
4	Liver	gene expression	Rac3	0.47	0.13	0.0e+00	0.5	0.5	0.51	0.5	4.0e-64	2.9e-64	2.2e-65	7.0e-64
5	Liver	mRNA stability	Rac3	0.03	0.02	1.5e-04	0.02	0.03	0.04	0.03	9.3e-04	6.7e-04	3.9e-05	3.6e-04
6	LHb	mRNA stability	Rac3	0.24	0.18	2.9e-03	0.1	0.04	0.06	0.07	2.2e-03	3.1e-02	1.9e-02	9.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.1	0.1	0.4	-0.4	-0.3	0.3	-0.1	-0.6	-0.4
Area under the delay curve	1.7	2.0	2.5	1.4	1.4	-1.4	-1.0	1.5	1.6
BMI with tail	0.2	0.7	1.6	-1.1	-0.7	0.6	0.2	-0.7	1.3
BMI without tail	1.5	4.6	8.3	-2.5	-2.3	2.3	0.9	-2.9	-1.4
Body weight	1.6	7.0	12.8	-3.6	-3.2	3.0	2.2	-2.3	-0.1
Weight adjusted by age	1.5	2.3	3.1	-1.8	-1.7	1.7	1.4	-1.5	-0.9
Bone surface	0.4	0.7	1.5	-0.5	-0.6	0.7	0.3	-1.1	-1.2
Bone volume	0.3	0.6	1.1	-0.6	-0.6	0.7	0.2	-1.0	-1.0
Breakpoint value in progressive ratio session	1.1	1.3	3.1	-1.2	-1.3	1.2	1.8	-0.0	0.2
Number of licking bursts	0.1	0.1	0.3	0.1	0.1	-0.0	-0.5	-0.5	-0.4
Context. condit. distance diff. score	0.4	0.5	1.2	0.0	0.1	0.1	-0.9	-1.1	-1.1
Locomotion velocity, session 1	0.9	1.0	1.8	0.9	0.8	-1.0	0.1	1.4	1.3
Locomotion distance, session 1	3.8	4.8	5.8	2.1	2.2	-2.3	-2.0	2.1	2.4
Locomotion velocity, session 2	3.6	4.2	5.5	2.2	2.1	-2.2	-1.3	2.4	2.0
Locomotion distance, session 2	1.0	1.3	2.4	0.9	1.1	-1.2	-1.1	1.0	1.6
Locomotion velocity, session 3	1.6	1.8	3.1	1.2	1.2	-1.3	-0.5	1.8	1.7
Locomotion distance, session 3	3.9	4.2	5.6	2.0	2.0	-2.1	-1.4	2.3	2.4
Stereotopy head waving bouts, day 3	0.5	0.5	1.2	0.5	0.5	-0.6	-0.1	1.0	1.1
Stereotopy head waving duration, day 3	0.5	0.6	1.1	0.6	0.6	-0.7	-0.4	1.0	1.0
Locomotion velocity, session 7	0.7	0.8	1.3	1.1	1.0	-1.0	-0.9	0.6	0.2
Locomotion distance, session 7	3.6	4.5	6.0	2.4	2.5	-2.4	-2.4	1.5	1.2
Stereotopy head waving bouts, day 7	0.2	0.2	0.4	-0.6	-0.5	0.5	0.3	-0.3	-0.1
Stereotopy head waving duration, day 7	0.2	0.2	0.4	-0.6	-0.6	0.5	0.3	-0.3	-0.2
Locomotion velocity, session 8	1.2	1.4	1.9	1.0	1.2	-1.2	-1.4	0.9	1.3
Locomotion distance, session 8	0.7	1.0	3.6	0.7	1.0	-0.9	-1.9	-0.2	0.3
Degree of sensitization distance	0.8	0.8	2.6	-0.4	-0.4	0.6	-0.1	-1.3	-1.6
Degree of sensitization stereotypy	0.2	0.2	0.4	-0.6	-0.5	0.5	0.2	-0.5	-0.2
Conditioned locomotion	2.6	3.0	5.0	-1.8	-1.7	1.8	0.6	-2.2	-1.9
Cocaine response after cond. corrected	0.2	0.2	0.7	-0.1	-0.2	0.1	0.5	0.7	0.9
Cocaine response after cond. not corrected	0.6	0.7	1.7	0.5	0.4	-0.5	-0.0	1.3	1.3
Cocaine response before conditioning	1.3	1.5	1.9	1.3	1.4	-1.3	-1.4	1.1	0.8
Saline control response	2.1	2.8	4.2	-1.7	-1.6	1.8	0.8	-2.1	-1.8
Bone: connectivity density	0.2	0.2	0.6	0.4	0.4	-0.3	-0.8	-0.3	-0.5
Bone: cortical apparent density	2.2	2.9	3.8	1.9	1.9	-1.9	-1.3	1.8	1.4
Bone: cortical area	3.8	5.8	11.0	-3.3	-2.9	2.6	2.3	-1.6	1.1
Bone: cortical porosity	1.6	1.7	4.0	-1.4	-1.5	1.4	2.0	-0.3	-0.0
Bone: cortical porosity	2.1	2.2	4.2	-1.7	-1.7	1.6	2.0	-0.8	-0.4
Bone: cortical thickness	4.1	6.7	12.1	-3.5	-3.0	2.5	2.7	-1.0	2.2
Bone: cortical thickness	1.3	1.6	2.9	-1.6	-1.3	1.0	1.2	-0.0	1.7
Bone: cortical tissue density	2.2	3.1	4.2	2.0	1.9	-2.0	-1.3	1.8	1.3
Condit. Reinf. active minus inactive responses	1.8	2.0	2.8	-1.7	-1.6	1.5	1.0	-1.6	-0.9
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.2	-1.1	-0.9	0.9	0.6	-0.6	0.1
Condit. Reinf. active responses	3.4	4.3	6.2	-2.3	-2.1	2.2	1.3	-2.5	-1.7
Condit. Reinf. inactive responses	1.4	1.7	3.0	-1.1	-1.1	1.2	0.6	-1.7	-1.7
Incentive salience index mean	1.3	1.6	2.4	-1.4	-1.3	1.3	0.8	-1.6	-1.0
Condit. Reinf. lever presses	0.1	0.1	0.3	0.2	0.3	-0.2	-0.5	-0.3	-0.3
Condit. Reinf. active minus inactive responses	0.3	0.3	0.7	-0.9	-0.6	0.5	0.4	-0.4	0.6
Condit. Reinf. active-inactive response ratio	1.8	2.0	3.4	-1.9	-1.7	1.6	1.5	-1.0	-0.2
Condit. Reinf. active responses	0.1	0.1	0.6	-0.2	-0.0	-0.0	-0.1	-0.0	0.7
Condit. Reinf. inactive responses	0.9	1.1	1.4	1.1	1.2	-1.2	-1.0	0.9	1.0
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.3	-0.4	-0.0
Condit. Reinf. lever reinforcers received	0.1	0.1	0.4	-0.2	0.0	-0.1	-0.3	-0.1	0.6
Conditioned reinforcement - actives	0.2	0.3	0.6	0.5	0.6	-0.5	-0.5	0.1	0.8
Conditioned reinforcement - inactives	0.2	0.2	0.4	-0.6	-0.6	0.6	0.4	-0.4	-0.3
Conditioned locomotion	0.1	0.1	0.2	0.2	0.2	-0.2	-0.4	-0.4	-0.0
Patch foraging indifference point 0 sec	0.1	0.2	0.4	-0.3	-0.4	0.4	0.2	-0.7	-0.6
Patch foraging indifference point AUC	0.1	0.1	0.4	-0.1	-0.1	0.1	-0.1	-0.5	-0.7
Delay disc. indifference point, 0s delay	0.2	0.2	1.1	0.1	0.2	-0.3	-0.1	0.5	1.1
Delay disc. indifference point, 16s delay	2.4	2.6	3.6	1.7	1.8	-1.7	-1.9	1.2	1.2
Delay disc. indifference point, 2s delay	0.3	0.3	0.6	0.6	0.5	-0.6	-0.2	0.7	0.7
Delay disc. indifference point, 24s delay	3.4	3.8	5.2	2.1	2.0	-2.1	-1.0	2.3	1.9
Delay disc. indifference point, 4s delay	0.5	0.5	1.3	0.4	0.4	-0.5	-0.2	1.0	1.2
Delay disc. indifference point, 8s delay	0.7	0.8	2.1	0.6	0.6	-0.7	-0.1	1.2	1.5
Indifference point function ln k	1.1	1.9	3.0	1.2	1.3	-1.3	-1.1	1.5	1.7
Indifference point function log k	1.1	1.9	3.0	1.2	1.3	-1.3	-1.1	1.5	1.7
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	-0.3	-0.3	0.4	0.1	-0.6	-0.4
Patch foraging total patch changes 12 sec	0.5	0.7	1.4	-0.5	-0.6	0.6	0.6	-1.2	-1.1
Patch foraging total patch changes 18 sec	0.1	0.2	0.4	0.3	0.4	-0.4	-0.7	-0.4	-0.3
Patch foraging total patch changes 24 sec	0.4	0.7	1.0	-0.9	-0.9	0.9	0.5	-1.0	-0.7
Patch foraging total patch changes 6 sec	0.5	0.8	1.1	-0.9	-0.9	0.9	0.8	-1.1	-0.8
Patch foraging time to switch 0 sec	0.2	0.4	0.8	0.9	0.8	-0.8	-0.5	0.4	0.1
Patch foraging water rate 0 sec	0.9	1.9	3.1	-1.7	-1.6	1.6	1.0	-1.4	-0.7
Patch foraging water rate 12 sec	0.1	0.2	0.9	-0.3	-0.0	-0.0	-0.4	0.1	0.9
Patch foraging water rate 18 sec	0.1	0.1	0.2	-0.5	-0.2	0.2	-0.5	-0.3	0.5
Patch foraging water rate 24 sec	0.4	0.6	1.3	-1.2	-0.8	0.8	-0.2	-1.1	-0.1
Patch foraging water rate 6 sec	0.4	0.5	2.7	-0.2	0.1	-0.3	-0.2	0.5	1.7
Seeking ratio, delayed vs. immediate footshock	0.9	1.1	1.6	-1.2	-1.2	1.2	0.8	-1.2	-0.8
Distance traveled before self-admin	1.1	1.4	2.2	-1.3	-1.4	1.3	1.5	-0.8	-0.3
Distance traveled after self-admin	1.1	1.3	3.5	-0.6	-0.7	0.9	0.2	-1.6	-1.9
Extensor digitorum longus weight	0.1	0.3	1.1	0.1	0.3	-0.3	-1.0	-0.5	0.1
Bone: elastic displacement	1.2	1.3	2.1	-1.5	-1.4	1.3	1.1	-1.0	-0.3
Bone: elastic work	7.3	9.5	14.7	-3.8	-3.7	3.4	3.4	-2.2	-0.5
Bone: endosteal estimation	0.2	0.4	0.8	0.5	0.5	-0.3	-0.9	-0.4	-0.9
Bone: endosteal perimeter	0.8	1.6	2.6	-1.1	-1.2	1.3	0.9	-1.5	-1.6
Epididymis fat weight	0.5	1.8	2.9	-1.7	-1.5	1.6	0.5	-1.6	-0.7
Delta time in closed arm before/after self-admin	0.5	0.5	1.3	0.7	0.7	-0.7	-1.1	0.6	0.1
Delta time in open arm before/after self-admin	0.0	0.0	0.1	0.2	0.2	-0.2	-0.1	-0.1	-0.3
Diff in mean of infusions in LGA sessions	0.3	0.4	0.8	-0.4	-0.6	0.7	0.9	-0.2	-0.7
Delay discount exponential model param	2.1	2.4	3.4	-1.5	-1.5	1.5	1.0	-1.8	-1.8
Extinction: sum of active levers before priming	0.5	0.6	1.1	0.6	0.6	-0.7	-0.2	1.0	1.0
Active lever presses in extinction session 6	1.6	1.6	5.5	-0.1	-0.1	-0.1	1.2	1.6	2.3
Bone: final force	3.8	6.1	11.7	-3.4	-3.0	2.7	2.2	-1.9	0.7
Bone: final moment	4.8	7.6	14.1	-3.8	-3.3	3.0	2.6	-2.1	0.4
Food consumed during 24 hour testing period	0.4	0.6	1.1	-0.6	-0.7	0.8	0.3	-1.0	-1.0
Glucose	3.6	5.6	15.4	1.6	1.3	-1.6	1.0	3.9	3.3
Heart weight	0.8	1.2	2.1	-1.5	-1.3	1.1	1.3	-0.7	0.3
Delay discount hyperbolic model param	1.8	2.0	3.0	-1.4	-1.4	1.4	0.8	-1.7	-1.6
Intermittent access intake day 1-15 change	1.3	2.6	5.4	-1.1	-1.4	1.4	1.5	-2.3	-1.7
Intermittent access intake escalation	1.1	2.3	4.9	-1.1	-1.3	1.3	1.3	-2.2	-1.5
Intermittent access intake escalation 2	3.5	4.0	5.4	-1.7	-2.0	2.0	2.3	-2.3	-1.6
Intermitt. access day 1 inactive lever presses	0.7	2.5	4.9	-1.6	-1.5	1.6	0.5	-2.2	-1.5
Intermitt. access day 15 inactive lever presses	0.3	0.6	1.5	-0.6	-0.5	0.6	-0.3	-1.1	-1.2
Intermitt. access escalation Index	0.3	0.4	1.0	-0.3	-0.3	0.4	-0.2	-1.0	-1.0
Intermittent access day 1 total infusions	0.0	0.1	0.3	-0.2	-0.1	0.1	0.1	-0.1	0.5
Intermittent access day 15 total infusions	0.7	1.0	2.8	-0.8	-0.9	0.9	0.7	-1.7	-0.8
Intermittent access terminal intake (last 3 days)	1.2	1.6	3.0	-1.0	-1.1	1.2	1.1	-1.7	-1.2
Intermittent access total infusions	0.2	0.3	0.8	-0.5	-0.5	0.5	0.4	-0.9	-0.3
Intermittent access day 1 locomotion	0.2	0.2	1.0	0.1	0.2	-0.3	-0.3	0.4	1.0
Intermittent access day 15 total locomotion	0.4	0.8	1.7	-0.8	-0.8	0.8	0.7	-1.3	-0.3
Intermittent access total locomotion	0.2	0.2	0.5	-0.5	-0.4	0.4	0.3	-0.7	0.2
Intermittent access standard deviation	0.1	0.3	1.0	-0.0	-0.2	0.1	1.0	-0.3	0.7
Left kidney weight	0.1	0.5	2.0	-0.6	-0.4	0.2	0.7	0.2	1.4
Right kidney weight	0.1	0.7	3.5	-0.4	-0.1	-0.1	0.3	0.4	1.9
Cocaine induced anxiety	2.0	2.9	6.3	-1.8	-1.8	1.6	2.5	0.3	1.4
Post-drug Anxiety	1.4	1.5	3.2	-0.8	-0.9	0.6	1.8	1.0	1.8
Baseline Anxiety	0.9	1.1	1.9	1.4	1.3	-1.2	-1.0	0.6	0.0
Tail length	3.0	11.6	14.0	-3.6	-3.6	3.7	2.4	-3.6	-3.3
Length with tail	1.6	6.8	10.3	-3.2	-3.1	3.0	2.9	-1.7	-0.7
Length without tail	0.8	2.5	5.1	-1.5	-1.4	1.1	2.3	0.8	1.9
Times rat made contact with spout	3.5	4.1	8.2	-1.4	-1.7	1.8	1.7	-2.2	-2.9
Lifetime Intake	0.0	0.1	0.3	-0.1	-0.1	0.1	0.1	-0.5	0.1
Liver weight, left	0.9	1.6	3.7	0.8	0.8	-0.9	-0.4	1.9	1.9
Liver weight, right	1.1	1.8	3.0	-1.7	-1.6	1.6	0.6	-1.4	-0.8
Locomotor activity	0.5	0.8	1.1	1.0	1.0	-1.0	-0.7	0.9	0.6
Locomotor testing distance	1.6	2.9	3.4	1.8	1.8	-1.8	-1.6	1.7	1.3
Locomotor testing rearing	0.4	0.9	1.4	1.2	1.1	-1.0	-1.2	0.4	-0.3
Locomotion in novel chamber	0.5	0.6	0.8	0.8	0.9	-0.8	-0.9	0.6	0.7
Locomotion in novel chamber post-restriction	3.2	5.2	6.7	-2.2	-2.3	2.4	1.6	-2.6	-2.4
Fecal boli incidents, locomotor time 1	0.4	0.6	0.9	0.9	0.9	-0.9	-1.0	0.4	-0.1
Change in fecal boli incidents, locomotor task	0.4	0.4	0.9	0.6	0.4	-0.4	0.7	0.9	0.7
Time >=10cm from walls, locomotor time 1	0.7	0.8	2.6	-0.3	-0.3	0.4	-0.5	-1.6	-1.2
Bouts of movement, locomotor time 1	1.2	1.4	2.3	1.2	1.2	-1.2	-0.8	1.5	0.9
Total resting periods, locomotor time 1	1.3	1.5	2.6	1.3	1.2	-1.3	-0.7	1.6	1.0
Rest time, locomotor task time 1	0.1	0.1	0.5	0.3	0.2	-0.2	0.3	0.7	0.3
Distance moved, locomotor task time 1	0.1	0.2	0.3	-0.5	-0.4	0.5	0.2	-0.6	-0.1
Vertical activity count, locomotor time 1	0.1	0.3	0.8	-0.7	-0.5	0.6	-0.0	-0.9	-0.3
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.3	-0.2	-0.2	0.1	0.1	-0.6	0.4
Bouts of movement, locomotor time 2	0.9	1.4	2.0	1.1	1.2	-1.2	-1.1	1.4	1.1
Total resting periods, locomotor time 2	0.6	1.1	1.5	1.0	1.1	-1.1	-1.2	1.1	0.8
Rest time, locomotor task time 2	0.1	0.1	0.5	0.3	0.1	-0.0	-0.2	0.2	-0.7
Distance moved, locomotor task time 2	0.2	0.2	1.3	-0.1	0.1	-0.2	0.1	0.2	1.2
Vertical activity count, locomotor time 2	0.2	0.3	1.4	0.1	0.3	-0.4	-0.5	0.1	1.2
Light reinforcement 1	0.3	0.9	2.0	-0.7	-0.6	0.7	-0.4	-1.3	-1.4
Light reinforcement 2	0.9	1.3	1.9	-1.3	-1.2	1.3	0.4	-1.4	-1.1
Bone: marrow area	0.2	0.4	0.8	0.5	0.5	-0.4	-0.9	-0.4	-0.8
Bone: maximum diameter	0.8	1.5	2.8	-1.7	-1.5	1.4	1.2	-1.0	0.3
Bone: maximum force	3.4	6.1	11.8	-3.4	-3.0	2.7	2.1	-2.0	0.5
Bone: maximum moment	4.3	7.5	13.9	-3.7	-3.3	3.0	2.5	-2.2	0.3
Mean time between licks in bursts	0.9	2.2	2.6	1.6	1.6	-1.6	-1.3	1.5	1.3
Mean num. licks in bursts	0.8	1.2	1.8	-0.9	-1.1	1.1	1.3	-0.9	-1.3
Cd content in liver	0.6	0.7	1.5	0.9	1.0	-0.9	-1.2	0.2	0.0
Co content in liver	0.2	0.2	0.7	-0.0	-0.1	0.2	0.0	-0.6	-0.8
Cu content in liver	1.3	1.6	1.9	-1.3	-1.4	1.4	1.4	-1.1	-0.9
Fe content in liver	0.6	0.8	1.0	1.0	1.0	-0.9	-1.0	0.7	0.5
K content in liver	0.8	0.8	1.8	-0.4	-0.4	0.6	-0.6	-1.3	-1.4
Mg content in liver	0.9	0.9	1.9	0.4	0.5	-0.2	-1.4	-1.1	-1.3
Mn content in liver	0.0	0.0	0.2	-0.2	-0.1	0.1	-0.1	0.1	0.4
Na content in liver	0.2	0.2	0.5	0.5	0.5	-0.4	-0.7	0.0	-0.0
Rb content in liver	1.0	1.2	2.6	-1.0	-0.9	1.0	0.0	-1.6	-1.3
Se content in liver	0.4	0.5	1.7	-0.4	-0.4	0.5	0.1	-0.9	-1.3
Sr content in liver	0.2	0.2	0.8	-0.1	-0.3	0.2	0.9	0.5	0.2
Zn content in liver	1.7	1.9	3.7	-1.1	-1.1	1.2	0.4	-1.9	-1.9
Bone: minimum diameter	2.5	4.6	6.8	-2.6	-2.5	2.4	1.9	-2.1	-1.0
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.3	-0.2	0.2	0.5	0.1	0.2
Time in novel zone, hab. session 1	0.0	0.0	0.1	0.2	0.2	-0.1	-0.4	-0.0	-0.2
Total zone transitions, hab. session 1	0.5	0.7	1.5	0.7	0.8	-0.9	-0.7	0.9	1.2
Total locomotion distance, hab. session 1	0.1	0.1	0.3	0.0	0.2	-0.2	-0.5	0.1	0.6
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.0	0.2	-0.2	-0.5	0.1	0.5
Time in familiar zone, hab. session 2	0.2	0.3	0.4	0.6	0.6	-0.6	-0.6	0.1	0.0
Time in novel zone, hab. session 2	0.2	0.2	0.6	0.1	0.1	-0.2	-0.1	0.6	0.8
Total zone transitions, hab. session 2	0.8	1.0	2.3	0.8	1.1	-1.0	-1.5	0.4	0.8
Total locomotion distance, hab. session 2	0.2	0.3	1.2	0.1	0.3	-0.3	-1.1	-0.4	-0.0
Locomotion velocity, hab. session 2	0.1	0.2	0.7	-0.2	0.0	0.0	-0.9	-0.6	-0.1
Novel to familiar place preference ratio	3.0	3.3	4.7	-2.2	-2.1	2.0	2.1	-1.2	-0.7
Novelty place preference	3.0	3.2	4.6	-2.1	-2.1	2.0	2.1	-1.2	-0.7
Time in novel zone, NPP test	2.4	2.5	3.7	-1.9	-1.9	1.8	1.8	-1.1	-0.6
Total zone transitions, NPP test	1.3	1.9	4.2	1.3	1.5	-1.4	-2.1	0.6	0.7
Total locomotion distance, NPP test	0.6	0.8	3.0	0.7	0.9	-0.8	-1.7	-0.1	0.3
Locomotion velocity, NPP test	0.3	0.4	1.6	0.3	0.5	-0.4	-1.3	-0.3	0.1
Intraocular pressure	0.8	1.1	1.8	-1.0	-0.9	1.0	0.4	-1.3	-1.3
Delta distance traveled before/after self-admin	0.6	0.6	1.1	0.8	0.7	-0.6	-1.0	-0.1	-0.9
Delta ambulatory time before/after self-admin	1.2	1.5	2.7	1.5	1.4	-1.2	-1.6	0.2	-0.8
Parametrial fat weight	0.3	0.8	1.5	-0.9	-0.8	0.9	0.2	-1.2	-1.0
Pavlov. Cond. lever latency	1.5	1.8	3.6	1.4	1.5	-1.5	-1.9	0.7	0.6
Pavlov. Cond. magazine entry latency	2.9	3.7	5.5	-2.2	-2.2	2.1	2.3	-1.3	-0.9
Pavlov. Cond. change in total contacts	0.8	0.8	2.0	-1.0	-1.0	0.9	1.4	-0.1	0.1
Pavlov. Cond. index score	3.4	4.3	5.6	-2.3	-2.4	2.3	2.3	-1.7	-1.2
Pavlov. Cond. latency score	3.0	3.8	5.2	-2.1	-2.2	2.2	2.3	-1.4	-1.1
Pavlov. Cond. lever contacts	0.9	1.1	1.7	-1.1	-1.2	1.1	1.3	-0.7	-0.5
Pavlov. Cond. magazine entry number	3.6	4.5	7.6	2.4	2.4	-2.3	-2.8	1.3	0.9
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.7	-0.2	-0.1	0.1	-0.5	-0.8	-0.7
Pavlov. Cond. lever-magazine prob. diff.	3.2	4.0	5.3	-2.3	-2.3	2.2	2.2	-1.6	-1.0
Pavlov. Cond. response bias	2.6	3.2	5.5	-2.0	-2.1	1.9	2.3	-1.0	-0.6
Pavlov. Cond. lever latency	0.5	0.7	1.6	0.6	0.5	-0.6	0.2	1.3	1.2
Pavlov. Cond. magazine entry latency	2.1	2.6	3.6	1.8	1.8	-1.8	-1.9	1.2	0.8
Pavlov. Cond. change in total contacts	0.2	0.4	0.8	0.7	0.7	-0.6	-0.9	0.2	0.0
Pavlov. Cond. index score	0.2	0.3	0.7	0.6	0.6	-0.5	-0.8	0.1	-0.0
Pavlov. Cond. latency score	0.3	0.4	1.0	0.6	0.7	-0.6	-1.0	0.1	-0.1
Pavlov. Cond. lever contacts	0.4	0.5	1.3	-0.4	-0.3	0.5	-0.3	-1.1	-1.1
Pavlov. Cond. magazine entry number	1.4	1.7	2.4	-1.5	-1.5	1.4	1.5	-1.1	-0.8
Pavlov. Cond. intertrial magazine entries	1.0	1.5	2.2	-1.5	-1.3	1.3	0.8	-1.4	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.9	0.8	0.8	-0.7	-1.0	0.4	0.1
Pavlov. Cond. response bias	0.1	0.1	0.4	0.3	0.3	-0.3	-0.6	-0.2	-0.2
Time in closed arm before self-admin	0.2	0.3	0.9	0.0	-0.0	-0.1	0.5	0.7	1.0
Time in closed arm after self-admin	0.5	0.5	1.6	0.5	0.4	-0.4	0.2	1.3	0.9
Time in open arm before self-admin	0.2	0.2	0.8	0.4	0.5	-0.4	-0.9	-0.3	-0.3
Time in open arm after self-admin	0.1	0.1	0.4	0.3	0.4	-0.4	-0.7	-0.2	0.1
Bone: periosteal estimation	0.9	1.8	3.4	-1.8	-1.6	1.5	1.0	-1.3	-0.0
Bone: periosteal perimeter	3.3	5.6	8.4	-2.9	-2.8	2.6	2.7	-1.7	-0.4
Bone: post-yield work	0.1	0.1	0.2	0.2	0.3	-0.4	-0.4	0.1	0.4
Progressive ratio test 1 active lever presses	0.3	0.3	1.0	-0.5	-0.5	0.5	0.3	-1.0	-0.4
Progressive ratio test 1 breakpoint	0.4	0.5	1.2	-0.6	-0.6	0.6	0.4	-1.1	-0.6
Progressive ratio test 1 inactive lever presses	1.6	2.4	4.9	-1.6	-1.4	1.5	0.4	-2.2	-1.5
Progressive ratio test 2 active lever presses	0.3	0.3	0.9	-0.5	-0.5	0.5	0.2	-0.9	-0.4
Progressive ratio test 2 breakpoint	0.3	0.3	0.9	-0.5	-0.5	0.5	0.3	-1.0	-0.4
Progressive ratio test 2 inactive lever presses	0.3	0.4	0.6	-0.7	-0.7	0.6	0.7	-0.7	0.1
Incentive Sensitization - Responses	0.2	0.3	0.8	-0.5	-0.5	0.6	0.2	-0.9	-0.7
Incentive Sensitization - Breakpoint	0.2	0.3	0.7	-0.5	-0.5	0.5	0.2	-0.8	-0.6
Sum of active levers in priming session hrs 5-6	1.2	1.2	2.7	-1.2	-1.2	1.2	1.7	-0.2	-0.0
Progressive ratio	0.7	1.0	1.3	1.0	1.0	-1.1	-0.7	1.1	1.1
Food seeking constrained by brief footshock	0.1	0.1	0.4	0.1	-0.1	0.1	0.6	0.2	-0.2
Seeking ratio, punishment vs. effort	0.1	0.2	0.4	-0.3	-0.3	0.4	0.0	-0.7	-0.6
Retroperitoneal fat weight	1.8	7.9	11.8	-3.1	-2.9	3.1	1.3	-3.4	-2.6
Reaction time number correct	0.7	1.4	5.1	0.9	1.1	-1.0	-2.3	-0.2	-0.0
Reaction time mean minus median	0.1	0.2	0.7	0.2	-0.0	0.1	0.4	-0.1	-0.8
Reaction time mean minus median AUC	0.0	0.1	0.3	0.0	-0.0	0.1	0.2	-0.2	-0.6
Reaction time num false alarms	0.1	0.1	0.2	0.5	0.4	-0.4	-0.3	0.0	-0.2
Reaction time num false alarms AUC	0.3	0.5	0.8	0.9	0.8	-0.8	-0.8	0.4	-0.0
Reaction time trials correct on left	0.7	1.4	5.1	0.9	1.1	-1.0	-2.3	-0.2	-0.0
Reaction time trials on left	0.8	1.4	5.3	0.9	1.2	-1.0	-2.3	-0.3	-0.0
Reaction time mean	0.3	0.4	1.0	-0.4	-0.4	0.5	0.2	-1.0	-1.0
Reaction time mean AUC	0.2	0.3	0.8	-0.1	-0.1	0.2	-0.2	-0.9	-0.9
Median of all reaction times	0.2	0.3	0.9	-0.4	-0.4	0.4	0.0	-1.0	-0.7
Reaction time omissions	0.1	0.2	0.7	-0.0	-0.0	0.1	-0.2	-0.7	-0.8
Reaction time false alarm rate	0.1	0.1	0.2	0.4	0.2	-0.2	0.5	0.4	-0.1
Reaction time premature initiation rate	0.8	1.1	1.6	1.3	1.2	-1.2	-0.8	1.1	0.4
Reaction time premature initiations	1.1	1.9	3.6	1.5	1.6	-1.5	-1.9	0.8	0.3
Std. dev. reaction times	0.2	0.3	0.5	0.7	0.6	-0.5	-0.4	-0.0	-0.6
Reaction time trials completed	0.8	1.4	5.3	0.9	1.2	-1.0	-2.3	-0.3	-0.0
Reaction time trials AUC	0.7	1.4	5.2	0.8	1.1	-1.0	-2.3	-0.3	-0.0
Run reversals in cocaine runway, females	0.8	0.8	1.7	1.0	1.0	-1.0	-1.3	0.3	0.1
Run reversals in cocaine runway, males	2.3	2.3	3.3	-1.5	-1.7	1.7	1.8	-1.0	-1.2
Latency to leave start box in cocaine runway	0.4	0.5	0.9	0.8	0.8	-0.8	-1.0	0.3	0.2
Latency to leave start box in cocaine runway, F	1.1	1.2	3.5	1.1	1.2	-1.1	-1.9	-0.0	-0.0
Latency to leave start box in cocaine runway, M	0.1	0.1	0.4	-0.2	-0.3	0.2	0.6	0.4	0.3
Std. dev. time between licks in bursts	0.4	0.5	2.3	0.3	0.5	-0.4	-1.5	-0.6	-0.1
Total sessions with >9 infusions	0.3	0.4	0.7	0.7	0.7	-0.7	-0.5	0.3	0.9
Short access day 1 total inactive lever presses	0.3	0.4	0.9	0.4	0.6	-0.6	-0.9	0.4	1.0
Short access day 10 total inactive lever presses	1.0	2.3	3.7	-1.9	-1.8	1.8	0.8	-1.4	-1.2
Short access day 1 total infusions	1.5	2.1	2.5	1.5	1.5	-1.6	-1.2	1.3	1.5
Short access day 10 total infusions	1.4	1.8	3.2	-1.2	-1.3	1.3	1.1	-1.8	-1.1
Short access total infusions	0.0	0.0	0.1	0.2	0.2	-0.2	-0.1	-0.1	0.3
Short access day 1 locomotion	0.3	0.4	2.0	0.3	0.3	-0.4	0.1	0.4	1.4
Short access day 10 total locomotion	0.1	0.2	0.9	-0.2	-0.3	0.2	1.0	0.1	0.6
Short access total locomotion	0.2	0.3	0.8	-0.2	-0.3	0.1	0.8	-0.2	0.9
One hour access (0.3 mA shock)	0.3	0.4	1.5	-0.4	-0.4	0.4	-0.0	-1.2	-0.7
Compulsive drug intake	0.2	0.2	0.3	-0.4	-0.3	0.4	-0.4	-0.6	-0.5
One hour access (shock baseline)	0.1	0.2	0.7	-0.0	-0.0	0.1	-0.1	-0.8	-0.5
Social response proportion	0.5	0.6	0.8	0.7	0.8	-0.8	-0.8	0.5	0.9
Social responses	0.5	0.7	1.4	0.6	0.7	-0.8	-0.8	0.6	1.2
Social time	0.4	0.5	1.4	0.4	0.6	-0.6	-0.6	0.6	1.2
Soleus weight	1.2	3.5	4.8	-2.0	-1.9	2.0	1.2	-2.2	-1.9
Bone: stiffness	0.6	0.9	3.7	-1.0	-0.6	0.4	0.4	0.2	1.9
Tibialis anterior weight	0.0	0.1	0.2	0.1	0.2	-0.1	-0.5	-0.4	-0.4
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.3	0.5	0.5	-0.5	-0.4	0.1	-0.4
Time to tail flick, vehicle, after self-admin	2.5	3.2	4.7	1.7	1.8	-1.8	-1.5	2.2	1.8
Time to tail flick, test, before self-admin	0.0	0.0	0.0	0.2	0.1	-0.1	-0.0	0.2	0.1
Time to tail flick, test, after self-admin	0.7	0.8	1.8	0.7	0.6	-0.7	-0.0	1.4	1.1
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.5	0.5	0.5	-0.5	-0.7	0.5	0.3
Delta time to tail flick, test, before/after SA	0.6	0.6	1.8	0.3	0.3	-0.5	0.3	1.1	1.3
Tibia length	8.1	22.2	35.8	-6.0	-5.6	5.3	4.8	-3.7	-1.1
Ambulatory time before self-admin	1.9	2.9	4.1	-2.0	-2.0	1.9	1.9	-1.4	-0.5
Ambulatory time after self-admin	0.6	0.7	1.6	-0.5	-0.6	0.7	0.2	-1.2	-1.3
Bone: tissue strength	0.8	0.8	1.7	-1.3	-1.0	1.0	0.3	-1.1	0.1
Total heroin consumption	0.6	0.7	1.7	-0.4	-0.4	0.3	1.0	0.9	1.3
Bone: trabecular number	0.0	0.1	0.2	-0.2	-0.2	0.2	0.2	-0.3	-0.4
Bone: trabecular spacing	0.4	0.5	2.2	0.4	0.6	-0.5	-1.5	-0.1	0.0
Bone: trabecular thickness	1.6	2.0	3.5	-1.4	-1.6	1.5	1.9	-1.0	-1.0
Bone: trabecular tissue density	0.8	1.2	1.6	1.2	1.2	-1.2	-1.0	1.0	0.9
Water consumed over 24 hours	0.1	0.2	0.4	-0.1	-0.3	0.3	0.7	-0.2	-0.6
Number of responses in last shaping day	0.5	0.5	2.5	0.2	0.3	-0.5	-0.2	0.3	1.6