Hub : Genes

Rab8a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Rab8a 0.2 0.11 2.7e-03 0.04 0.06 0.07 0.07 5.5e-03 2.2e-03 5.3e-04 7.2e-04
2 pVTA mRNA stability Rab8a 0.06 0.04 2.7e-03 0.04 0.03 0.03 0.03 5.0e-04 2.7e-03 1.9e-03 2.5e-03
3 PL gene expression Rab8a 0.09 0.05 1.1e-09 0.1 0.1 0.1 0.11 1.7e-10 3.8e-11 1.7e-11 1.3e-11
4 BLA gene expression Rab8a 0.13 0.09 1.2e-04 0.06 0.04 0.02 0.07 3.5e-04 2.6e-03 1.8e-02 1.8e-04
5 NAcc mRNA stability Rab8a 0.02 0.01 3.5e-04 0.01 0.02 0.02 0.02 2.7e-03 1.3e-04 4.4e-04 3.9e-04
6 Liver mRNA stability Rab8a 0.03 0.02 1.1e-03 0 0.01 0 0.01 8.5e-02 1.2e-02 1.1e-01 5.0e-02
7 Brain gene expression Rab8a 0.14 0.07 4.7e-07 0.07 0.05 0.09 0.08 3.9e-07 3.2e-05 1.7e-08 3.3e-08
8 NAcc gene expression Rab8a 0.04 0.02 1.3e-05 0.02 0.03 0.03 0.02 1.5e-04 4.2e-05 1.0e-04 1.2e-04
9 Liver gene expression Rab8a 0.01 0.01 9.1e-03 0 0.01 0 0 2.8e-01 3.4e-02 8.7e-02 1.1e-01
10 Adipose mRNA stability Rab8a 0.06 0.04 5.5e-05 0.01 0.04 0.04 0.03 4.2e-02 8.1e-05 5.6e-05 1.9e-04
11 IL gene expression Rab8a 0.14 0.11 9.2e-03 0.08 0.04 0.07 0.05 5.5e-03 3.5e-02 9.1e-03 2.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density2.34.07.3-2.61.5-2.4-2.5-0.4-0.4-2.7-2.4-1.3-0.8-2.7
Area under the delay curve0.70.82.21.2-0.61.21.50.30.31.11.00.7-0.10.5
BMI with tail0.82.89.0-3.02.5-1.9-2.30.50.7-1.4-1.2-0.21.2-0.9
BMI without tail1.13.310.7-2.93.3-1.2-1.71.61.8-0.8-0.50.82.20.0
Body weight2.611.431.8-5.64.6-4.0-4.70.91.2-3.5-3.1-0.81.4-2.6
Weight adjusted by age1.01.53.9-2.01.9-1.1-1.60.80.9-1.1-0.80.21.0-0.9
Bone surface2.13.86.6-2.10.7-2.4-2.3-1.1-1.0-2.5-2.4-1.7-1.3-2.6
Bone volume2.13.76.5-2.51.5-2.4-2.5-0.4-0.3-2.5-2.3-1.2-0.7-2.5
Breakpoint value in progressive ratio session0.91.12.5-0.3-0.8-0.8-0.6-1.6-1.5-0.8-1.1-1.5-1.3-0.4
Number of licking bursts0.20.30.70.8-0.40.80.80.10.00.60.50.3-0.00.7
Context. condit. distance diff. score0.20.20.7-0.60.5-0.4-0.50.10.0-0.8-0.6-0.2-0.2-0.7
Locomotion velocity, session 14.75.07.7-2.1-0.0-2.8-2.7-2.1-2.0-2.6-2.7-2.6-1.5-2.1
Locomotion distance, session 13.34.26.5-0.6-1.3-1.9-1.4-2.4-2.4-2.1-2.2-2.5-2.5-2.1
Locomotion velocity, session 21.51.84.6-2.11.5-1.6-1.90.00.1-1.6-1.4-0.60.3-1.1
Locomotion distance, session 21.82.64.8-0.2-1.5-1.4-1.0-2.2-2.2-1.4-1.6-2.1-1.8-1.1
Locomotion velocity, session 30.20.30.6-0.40.1-0.6-0.5-0.4-0.4-0.6-0.6-0.6-0.4-0.7
Locomotion distance, session 31.11.22.6-0.4-0.6-0.9-0.7-1.0-1.1-1.3-1.2-1.2-1.5-1.6
Stereotopy head waving bouts, day 30.30.30.5-0.2-0.5-0.5-0.4-0.7-0.7-0.4-0.6-0.7-0.7-0.3
Stereotopy head waving duration, day 30.10.20.2-0.3-0.2-0.5-0.4-0.4-0.4-0.4-0.5-0.5-0.4-0.2
Locomotion velocity, session 70.30.30.80.9-0.90.60.7-0.4-0.50.40.4-0.1-0.20.4
Locomotion distance, session 70.50.61.41.2-0.91.11.1-0.1-0.20.80.80.30.20.9
Stereotopy head waving bouts, day 71.31.52.2-0.9-0.4-1.5-1.3-1.1-1.1-1.4-1.4-1.4-1.4-1.1
Stereotopy head waving duration, day 70.80.91.5-1.10.2-1.2-1.2-0.6-0.6-1.2-1.2-0.9-0.9-0.8
Locomotion velocity, session 82.93.56.8-1.5-0.0-2.0-2.0-1.5-1.5-2.5-2.2-1.9-1.5-2.6
Locomotion distance, session 81.72.53.7-0.7-0.8-1.6-1.3-1.7-1.7-1.8-1.9-1.9-1.7-1.6
Degree of sensitization distance1.61.73.91.2-0.31.51.40.60.71.71.51.11.22.0
Degree of sensitization stereotypy1.21.31.9-0.8-0.2-1.4-1.2-0.9-1.0-1.4-1.3-1.2-1.3-1.2
Conditioned locomotion0.20.20.6-0.70.8-0.2-0.50.40.3-0.7-0.50.0-0.0-0.2
Cocaine response after cond. corrected2.53.04.41.00.81.91.82.01.91.81.92.11.91.5
Cocaine response after cond. not corrected0.91.12.00.30.91.10.91.41.40.81.01.41.30.4
Cocaine response before conditioning2.42.94.2-1.5-0.2-2.0-1.9-1.6-1.5-1.9-1.9-1.8-1.4-2.0
Saline control response1.01.42.3-1.2-0.0-1.5-1.5-1.2-1.0-1.3-1.3-1.3-1.0-0.8
Bone: connectivity density1.52.33.7-1.80.7-1.9-1.9-0.8-0.7-1.9-1.9-1.3-1.0-1.9
Bone: cortical apparent density0.00.00.2-0.20.1-0.2-0.2-0.1-0.0-0.00.1-0.00.40.0
Bone: cortical area2.53.89.1-3.02.8-1.9-2.21.11.2-2.2-1.8-0.10.5-2.2
Bone: cortical porosity1.11.21.8-0.8-0.4-1.2-1.1-1.2-1.2-1.1-1.2-1.3-1.0-1.1
Bone: cortical porosity1.21.32.1-0.6-0.7-1.1-0.9-1.4-1.4-1.0-1.2-1.4-1.3-1.1
Bone: cortical thickness3.15.211.0-3.32.7-2.6-2.80.60.6-3.0-2.5-0.7-0.1-2.9
Bone: cortical thickness1.41.73.7-1.71.5-1.2-1.20.60.4-1.9-1.5-0.3-0.8-1.9
Bone: cortical tissue density0.00.00.2-0.0-0.1-0.2-0.2-0.1-0.10.00.1-0.00.40.1
Condit. Reinf. active minus inactive responses0.80.91.3-0.6-0.3-1.1-0.8-0.9-0.9-1.0-1.1-1.1-1.0-0.9
Condit. Reinf. active-inactive response ratio0.20.30.9-0.30.1-0.4-0.3-0.1-0.1-0.8-0.6-0.3-0.7-0.9
Condit. Reinf. active responses0.91.11.8-0.4-0.6-1.3-0.8-1.3-1.2-1.0-1.2-1.3-1.2-0.9
Condit. Reinf. inactive responses0.10.10.40.3-0.5-0.30.1-0.6-0.50.0-0.2-0.4-0.30.2
Incentive salience index mean3.03.76.1-1.6-0.3-2.5-2.1-1.8-1.7-2.2-2.3-2.2-1.6-2.0
Condit. Reinf. lever presses5.17.111.7-2.1-0.5-3.4-3.0-2.6-2.5-3.0-3.1-3.1-2.1-2.7
Condit. Reinf. active minus inactive responses0.70.91.5-1.00.1-1.2-1.2-0.7-0.6-1.2-1.0-0.9-0.5-1.1
Condit. Reinf. active-inactive response ratio0.70.82.1-1.51.2-1.0-1.20.40.4-1.1-0.8-0.10.5-1.0
Condit. Reinf. active responses0.40.60.9-0.5-0.4-0.8-0.8-1.0-0.9-0.7-0.7-0.9-0.7-0.5
Condit. Reinf. inactive responses0.70.92.01.3-1.40.80.9-0.8-0.71.20.8-0.2-0.51.1
Condit. Reinf. lever presses0.20.30.8-0.80.9-0.4-0.60.30.4-0.3-0.20.20.5-0.2
Condit. Reinf. lever reinforcers received0.00.00.2-0.40.1-0.3-0.4-0.2-0.1-0.0-0.1-0.20.00.2
Conditioned reinforcement - actives0.91.63.6-0.91.80.5-0.31.91.90.40.71.51.80.4
Conditioned reinforcement - inactives2.53.711.8-2.53.4-0.4-1.42.52.7-0.8-0.11.61.8-0.3
Conditioned locomotion2.22.96.4-0.31.91.30.52.52.51.11.42.22.11.1
Patch foraging indifference point 0 sec0.20.30.9-0.90.8-0.3-0.60.20.30.1-0.00.10.90.7
Patch foraging indifference point AUC0.00.10.2-0.40.3-0.1-0.3-0.00.10.20.20.10.50.2
Delay disc. indifference point, 0s delay0.80.92.41.5-1.40.91.3-0.5-0.50.90.80.0-0.70.6
Delay disc. indifference point, 16s delay2.62.95.72.1-0.82.32.40.80.82.12.11.50.51.9
Delay disc. indifference point, 2s delay0.60.71.50.4-1.2-0.20.3-1.2-1.2-0.3-0.4-0.9-1.2-0.5
Delay disc. indifference point, 24s delay0.80.91.40.50.21.11.10.90.91.21.11.10.91.1
Delay disc. indifference point, 4s delay0.40.41.3-0.3-0.2-0.4-0.2-0.6-0.6-0.6-0.6-0.7-0.8-1.1
Delay disc. indifference point, 8s delay1.72.03.91.7-0.61.82.00.80.81.91.81.30.51.4
Indifference point function ln k0.20.31.2-0.20.90.20.21.10.9-0.10.00.70.5-0.1
Indifference point function log k0.20.31.2-0.20.90.20.21.10.9-0.10.00.70.5-0.1
Patch foraging total patch changes 0 sec0.40.72.1-1.21.4-0.3-0.70.70.90.20.10.51.40.8
Patch foraging total patch changes 12 sec0.30.41.1-0.91.1-0.2-0.50.50.70.10.20.51.00.1
Patch foraging total patch changes 18 sec0.20.30.70.5-0.70.30.3-0.7-0.40.80.6-0.10.10.8
Patch foraging total patch changes 24 sec0.20.30.6-0.7-0.0-0.7-0.8-0.7-0.4-0.3-0.4-0.6-0.2-0.3
Patch foraging total patch changes 6 sec0.20.31.7-0.50.7-0.1-0.30.20.30.50.30.21.30.7
Patch foraging time to switch 0 sec0.40.82.70.9-1.60.10.5-1.2-1.2-0.0-0.1-0.8-1.2-0.4
Patch foraging water rate 0 sec0.51.03.2-1.61.8-0.8-1.20.80.9-0.6-0.40.31.2-0.0
Patch foraging water rate 12 sec0.30.61.6-1.01.3-0.4-0.71.00.9-0.5-0.30.50.5-0.1
Patch foraging water rate 18 sec0.71.02.0-1.00.2-1.1-1.2-0.7-0.8-1.4-1.4-1.1-0.8-0.9
Patch foraging water rate 24 sec1.31.93.3-1.80.8-1.8-1.7-0.5-0.5-1.8-1.7-1.1-1.2-1.3
Patch foraging water rate 6 sec0.60.82.4-0.91.60.1-0.31.51.4-0.6-0.11.00.5-0.3
Seeking ratio, delayed vs. immediate footshock0.20.20.5-0.10.40.50.40.50.50.40.40.50.70.2
Distance traveled before self-admin0.30.41.6-1.31.0-0.6-0.80.10.1-0.7-0.7-0.30.1-0.3
Distance traveled after self-admin1.31.73.3-1.80.7-1.8-1.7-0.7-0.5-1.6-1.5-1.1-0.4-1.3
Extensor digitorum longus weight0.62.46.1-2.52.0-1.8-2.20.40.6-1.7-1.4-0.30.8-1.3
Bone: elastic displacement1.01.22.0-1.00.0-1.4-1.2-1.0-0.9-1.3-1.2-1.2-0.6-1.4
Bone: elastic work0.91.22.9-1.61.7-1.0-1.10.70.8-1.1-0.70.10.8-1.2
Bone: endosteal estimation0.71.63.21.2-0.21.71.60.90.91.81.51.20.81.4
Bone: endosteal perimeter0.40.81.20.60.11.01.01.00.91.11.01.10.70.8
Epididymis fat weight0.10.41.4-1.20.9-0.8-0.9-0.10.10.0-0.4-0.20.50.4
Delta time in closed arm before/after self-admin0.70.61.71.2-0.70.80.9-0.1-0.00.90.90.40.11.3
Delta time in open arm before/after self-admin0.20.20.4-0.1-0.4-0.6-0.4-0.6-0.6-0.3-0.4-0.6-0.6-0.6
Diff in mean of infusions in LGA sessions0.30.31.5-1.11.20.1-0.40.40.6-0.1-0.20.20.60.1
Delay discount exponential model param0.40.41.3-0.90.4-0.9-1.2-0.3-0.3-0.7-0.7-0.50.1-0.2
Extinction: sum of active levers before priming2.22.55.3-0.3-1.3-1.5-0.7-2.3-2.1-1.2-1.4-2.0-2.2-0.9
Active lever presses in extinction session 60.10.10.40.3-0.20.10.2-0.0-0.10.10.20.00.20.7
Bone: final force2.33.711.7-2.83.4-1.3-1.82.02.1-1.4-0.90.91.5-1.2
Bone: final moment1.93.110.5-2.33.2-0.8-1.32.22.2-0.9-0.51.21.6-0.9
Food consumed during 24 hour testing period1.21.73.00.0-1.3-1.3-0.7-1.7-1.7-1.0-1.1-1.6-1.7-0.9
Glucose0.10.10.4-0.30.4-0.2-0.30.30.30.30.10.20.60.3
Heart weight1.52.35.1-1.60.6-1.9-1.7-0.4-0.4-2.1-1.8-1.1-1.1-2.3
Delay discount hyperbolic model param0.20.20.7-0.60.5-0.6-0.90.00.0-0.4-0.4-0.20.40.1
Intermittent access intake day 1-15 change0.40.81.8-0.90.3-1.2-1.4-0.3-0.3-1.0-1.0-0.7-0.4-1.2
Intermittent access intake escalation0.30.71.5-0.70.2-1.0-1.2-0.4-0.4-1.0-1.0-0.7-0.5-1.2
Intermittent access intake escalation 20.30.41.0-0.70.4-0.7-1.00.00.0-0.6-0.6-0.3-0.1-1.0
Intermitt. access day 1 inactive lever presses0.20.71.7-1.11.3-0.7-1.20.70.9-0.4-0.20.40.9-0.1
Intermitt. access day 15 inactive lever presses0.20.40.8-0.50.9-0.4-0.70.80.8-0.2-0.00.50.9-0.2
Intermitt. access escalation Index0.20.20.70.8-0.70.30.8-0.3-0.20.30.40.0-0.40.0
Intermittent access day 1 total infusions2.64.16.70.41.62.21.52.62.41.82.02.52.42.0
Intermittent access day 15 total infusions0.60.92.2-0.41.30.50.01.51.30.40.51.11.30.4
Intermittent access terminal intake (last 3 days)0.50.71.7-0.00.90.70.31.31.10.50.71.11.10.5
Intermittent access total infusions2.22.65.6-0.31.91.10.52.42.21.01.32.02.21.1
Intermittent access day 1 locomotion1.92.54.2-0.31.81.40.82.12.01.31.31.92.01.5
Intermittent access day 15 total locomotion0.10.20.60.30.10.80.60.30.20.60.40.30.30.6
Intermittent access total locomotion1.01.12.5-0.41.60.80.31.61.50.60.71.31.30.7
Intermittent access standard deviation0.30.61.4-0.61.1-0.0-0.51.21.2-0.20.10.80.8-0.1
Left kidney weight0.52.56.4-2.51.4-2.3-2.4-0.7-0.2-1.4-1.6-1.00.6-1.3
Right kidney weight0.73.09.3-3.02.2-2.3-2.7-0.10.4-1.1-1.4-0.61.5-0.8
Cocaine induced anxiety0.30.42.0-0.80.7-0.6-0.80.40.60.10.20.31.40.4
Post-drug Anxiety0.30.31.3-0.50.6-0.3-0.60.40.60.30.20.41.10.3
Baseline Anxiety0.10.20.60.5-0.50.40.5-0.2-0.30.0-0.1-0.2-0.8-0.5
Tail length0.52.05.8-2.42.1-1.7-2.00.40.7-1.3-1.2-0.20.9-0.5
Length with tail1.46.014.5-3.82.6-3.2-3.6-0.20.1-2.7-2.6-1.20.4-2.2
Length without tail0.82.54.5-2.11.2-2.1-2.1-0.5-0.4-1.8-1.8-1.1-0.6-2.0
Times rat made contact with spout0.10.10.40.3-0.6-0.30.0-0.5-0.6-0.2-0.1-0.4-0.5-0.2
Lifetime Intake2.73.27.4-0.92.50.90.12.72.60.61.12.22.50.9
Liver weight, left1.22.02.7-0.9-0.4-1.5-1.2-1.5-1.4-1.5-1.6-1.7-1.5-1.6
Liver weight, right0.71.23.3-1.81.5-1.3-1.60.30.6-0.7-0.6-0.01.3-0.5
Locomotor activity2.03.15.4-0.9-1.1-2.0-1.8-2.2-2.3-1.6-1.9-2.3-1.7-1.1
Locomotor testing distance0.61.22.2-0.5-0.8-1.1-1.1-1.4-1.5-0.9-1.1-1.5-1.1-0.3
Locomotor testing rearing1.93.87.7-0.4-1.9-1.7-1.4-2.8-2.8-1.3-1.7-2.6-2.4-0.9
Locomotion in novel chamber0.20.30.8-0.90.6-0.5-0.5-0.2-0.2-0.3-0.7-0.5-0.1-0.5
Locomotion in novel chamber post-restriction2.64.27.0-0.6-1.5-1.6-1.1-2.6-2.6-1.8-2.1-2.6-2.6-2.0
Fecal boli incidents, locomotor time 11.92.85.42.1-1.42.22.30.10.02.21.90.90.32.3
Change in fecal boli incidents, locomotor task0.10.10.20.2-0.10.30.20.10.10.40.30.20.20.3
Time >=10cm from walls, locomotor time 11.21.32.91.3-0.91.51.4-0.1-0.01.61.30.50.21.7
Bouts of movement, locomotor time 10.20.20.60.7-0.8-0.00.1-0.7-0.80.10.0-0.5-0.1-0.1
Total resting periods, locomotor time 10.30.41.21.0-1.10.30.5-0.8-0.80.40.2-0.4-0.10.3
Rest time, locomotor task time 10.70.81.70.70.21.31.11.00.90.90.91.10.80.6
Distance moved, locomotor task time 10.00.00.1-0.1-0.2-0.3-0.4-0.3-0.20.10.1-0.20.20.2
Vertical activity count, locomotor time 10.51.32.6-1.50.5-1.6-1.6-0.7-0.6-1.4-1.3-1.0-0.6-1.0
Time >=10cm from walls, locomotor time 20.81.22.81.0-0.11.71.31.00.81.21.21.20.41.2
Bouts of movement, locomotor time 20.71.22.30.1-1.0-1.0-0.7-1.2-1.3-1.0-1.0-1.3-1.5-1.1
Total resting periods, locomotor time 20.61.12.10.3-1.2-0.9-0.6-1.2-1.3-0.9-0.9-1.2-1.5-0.9
Rest time, locomotor task time 20.10.10.4-0.30.3-0.1-0.0-0.00.0-0.5-0.5-0.2-0.5-0.7
Distance moved, locomotor task time 21.01.22.40.9-0.10.90.60.90.91.51.51.21.61.2
Vertical activity count, locomotor time 20.10.20.4-0.50.5-0.5-0.60.40.3-0.4-0.10.20.3-0.1
Light reinforcement 10.10.31.30.6-0.20.60.60.20.30.60.80.50.21.1
Light reinforcement 21.82.74.01.10.42.01.61.61.61.72.01.91.71.8
Bone: marrow area0.71.52.91.2-0.31.61.50.80.81.71.41.10.81.3
Bone: maximum diameter0.81.43.9-1.62.0-0.7-0.91.31.3-1.1-0.70.50.6-1.4
Bone: maximum force2.13.79.2-3.02.9-2.0-2.31.21.2-2.0-1.60.10.8-1.9
Bone: maximum moment1.42.56.9-2.42.6-1.4-1.71.31.4-1.4-1.10.40.9-1.5
Mean time between licks in bursts0.51.24.0-1.42.0-0.4-0.81.21.3-0.10.10.81.50.6
Mean num. licks in bursts0.20.40.9-0.60.1-0.9-0.8-0.4-0.3-0.8-0.6-0.5-0.4-0.9
Cd content in liver1.31.43.4-0.41.60.70.51.91.80.50.71.51.40.5
Co content in liver0.20.30.8-0.60.3-0.6-0.5-0.2-0.1-0.7-0.7-0.4-0.4-0.9
Cu content in liver3.84.58.2-0.5-1.5-1.9-1.4-2.5-2.6-2.0-2.2-2.6-2.9-2.2
Fe content in liver0.10.10.30.6-0.50.20.4-0.2-0.20.10.2-0.0-0.40.0
K content in liver0.40.41.21.1-0.90.70.8-0.3-0.30.60.50.1-0.50.4
Mg content in liver0.00.00.00.0-0.1-0.0-0.1-0.1-0.1-0.1-0.1-0.1-0.2-0.1
Mn content in liver0.20.30.5-0.3-0.1-0.5-0.4-0.4-0.4-0.7-0.6-0.5-0.7-0.7
Na content in liver1.01.02.70.2-1.2-0.7-0.5-1.6-1.5-0.4-0.7-1.3-1.2-0.5
Rb content in liver2.22.64.50.71.01.81.42.12.01.41.72.11.61.4
Se content in liver0.50.61.40.1-0.8-0.6-0.3-1.1-1.2-0.4-0.6-1.0-1.0-0.5
Sr content in liver0.00.00.1-0.30.3-0.1-0.2-0.00.00.2-0.1-0.00.3-0.0
Zn content in liver0.30.40.6-0.5-0.2-0.7-0.7-0.7-0.6-0.5-0.7-0.7-0.4-0.5
Bone: minimum diameter0.51.02.8-1.61.7-0.7-1.00.91.0-0.5-0.50.41.0-0.7
Time in familiar zone, hab. session 10.10.10.2-0.40.4-0.3-0.30.00.0-0.4-0.3-0.1-0.1-0.3
Time in novel zone, hab. session 10.00.00.00.0-0.00.10.20.10.1-0.00.10.10.0-0.0
Total zone transitions, hab. session 10.81.11.6-0.2-0.8-0.8-0.6-1.2-1.3-1.2-1.1-1.3-1.2-1.0
Total locomotion distance, hab. session 12.02.85.70.5-2.2-1.0-0.4-2.3-2.4-1.2-1.3-2.1-2.2-1.2
Locomotion velocity, hab. session 11.82.65.20.6-2.1-0.9-0.4-2.2-2.3-1.0-1.2-2.0-2.1-1.1
Time in familiar zone, hab. session 20.40.41.1-0.91.0-0.3-0.60.40.4-0.9-0.60.10.3-0.5
Time in novel zone, hab. session 20.70.71.61.1-0.70.91.00.20.11.31.10.60.21.0
Total zone transitions, hab. session 20.10.20.50.3-0.5-0.00.1-0.5-0.6-0.3-0.3-0.5-0.7-0.1
Total locomotion distance, hab. session 21.51.94.40.0-1.2-1.1-0.7-1.6-1.7-1.3-1.4-1.7-2.1-1.2
Locomotion velocity, hab. session 21.62.24.50.0-1.3-1.2-0.8-1.8-1.9-1.4-1.5-1.8-2.1-1.3
Novel to familiar place preference ratio1.31.42.21.0-0.11.51.40.90.91.51.51.21.21.4
Novelty place preference1.71.82.91.3-0.31.71.60.90.81.71.61.31.11.5
Time in novel zone, NPP test1.61.83.11.4-0.51.81.70.70.61.71.61.10.91.6
Total zone transitions, NPP test1.01.43.10.4-1.4-0.6-0.2-1.7-1.8-0.7-0.9-1.5-1.6-0.6
Total locomotion distance, NPP test2.73.77.5-0.1-1.7-1.5-1.0-2.4-2.5-1.8-1.9-2.4-2.7-1.7
Locomotion velocity, NPP test2.02.96.00.1-1.6-1.3-0.8-2.2-2.2-1.4-1.6-2.1-2.4-1.3
Intraocular pressure0.71.02.30.11.11.00.91.51.40.50.71.30.80.8
Delta distance traveled before/after self-admin0.60.71.6-1.00.4-1.3-1.1-0.6-0.4-0.9-0.8-0.7-0.1-1.1
Delta ambulatory time before/after self-admin0.20.30.7-0.4-0.1-0.8-0.6-0.6-0.5-0.5-0.4-0.5-0.2-0.7
Parametrial fat weight2.86.512.2-0.32.61.81.03.43.51.92.23.23.42.4
Pavlov. Cond. lever latency4.15.28.91.90.43.02.72.32.12.52.72.61.82.1
Pavlov. Cond. magazine entry latency0.10.10.3-0.50.5-0.3-0.40.20.3-0.0-0.10.10.40.1
Pavlov. Cond. change in total contacts1.31.43.0-1.60.7-1.7-1.7-0.6-0.4-1.3-1.3-0.9-0.1-1.2
Pavlov. Cond. index score1.31.73.1-1.1-0.3-1.8-1.6-1.4-1.2-1.3-1.5-1.5-0.9-1.0
Pavlov. Cond. latency score2.32.95.0-1.3-0.4-2.2-2.0-1.9-1.6-1.7-1.9-2.0-1.3-1.4
Pavlov. Cond. lever contacts2.83.46.1-1.5-0.3-2.5-2.2-1.9-1.7-1.9-2.1-2.1-1.4-1.7
Pavlov. Cond. magazine entry number0.10.10.30.6-0.40.40.50.0-0.20.00.10.0-0.4-0.2
Pavlov. Cond. intertrial magazine entries1.41.73.7-0.2-0.9-1.1-0.7-1.4-1.5-1.3-1.4-1.5-1.9-1.3
Pavlov. Cond. lever-magazine prob. diff.1.01.22.4-1.0-0.1-1.5-1.5-1.2-1.0-1.1-1.2-1.2-0.7-0.8
Pavlov. Cond. response bias0.60.71.5-1.00.2-1.2-1.2-0.7-0.5-0.9-1.0-0.8-0.4-0.7
Pavlov. Cond. lever latency0.50.61.71.3-1.20.91.1-0.4-0.50.50.4-0.1-0.80.5
Pavlov. Cond. magazine entry latency0.30.41.0-1.00.9-0.6-0.80.40.4-0.1-0.10.21.00.1
Pavlov. Cond. change in total contacts0.60.92.7-1.61.4-1.0-1.30.40.6-0.5-0.40.11.1-0.4
Pavlov. Cond. index score0.60.81.9-1.41.4-0.8-1.10.70.8-0.3-0.20.31.2-0.2
Pavlov. Cond. latency score0.60.72.0-1.41.2-1.0-1.20.40.5-0.5-0.40.11.0-0.4
Pavlov. Cond. lever contacts0.40.61.8-1.31.1-1.0-1.10.30.4-0.6-0.5-0.10.7-0.5
Pavlov. Cond. magazine entry number1.01.23.01.6-1.70.81.2-1.0-1.00.40.2-0.5-1.70.2
Pavlov. Cond. intertrial magazine entries0.30.51.30.8-1.20.50.5-0.8-0.80.40.2-0.4-0.70.5
Pavlov. Cond. lever-magazine prob. diff.0.60.82.0-1.41.4-0.8-1.10.70.7-0.4-0.30.31.2-0.3
Pavlov. Cond. response bias0.50.61.7-1.31.2-0.8-1.10.60.6-0.3-0.20.21.1-0.2
Time in closed arm before self-admin2.43.09.8-2.83.1-0.8-1.61.81.9-0.9-0.60.91.7-0.8
Time in closed arm after self-admin2.22.35.4-0.62.20.80.22.22.30.61.01.91.80.9
Time in open arm before self-admin2.42.65.8-0.1-1.6-1.4-1.0-2.4-2.4-1.1-1.4-2.2-1.7-0.8
Time in open arm after self-admin5.05.58.2-1.4-0.8-2.8-2.3-2.5-2.5-2.6-2.7-2.9-2.1-2.4
Bone: periosteal estimation0.30.51.6-0.81.3-0.0-0.21.11.1-0.1-0.10.70.7-0.3
Bone: periosteal perimeter0.61.13.4-1.11.8-0.1-0.41.51.5-0.10.11.01.2-0.3
Bone: post-yield work0.20.30.90.8-1.00.30.5-0.5-0.60.10.1-0.3-0.7-0.1
Progressive ratio test 1 active lever presses0.60.82.7-1.11.60.1-0.21.11.10.10.10.71.30.2
Progressive ratio test 1 breakpoint0.60.72.5-1.11.60.1-0.21.11.0-0.00.10.71.20.2
Progressive ratio test 1 inactive lever presses0.81.12.4-1.61.6-1.1-1.40.81.0-0.9-0.50.40.9-0.6
Progressive ratio test 2 active lever presses1.31.62.90.11.31.30.81.71.61.01.21.61.60.9
Progressive ratio test 2 breakpoint1.21.42.60.11.21.30.81.61.50.91.11.51.40.8
Progressive ratio test 2 inactive lever presses0.61.03.1-0.81.80.4-0.11.51.40.10.41.11.30.3
Incentive Sensitization - Responses2.33.26.41.70.22.52.21.71.52.02.11.91.31.5
Incentive Sensitization - Breakpoint2.63.46.81.80.02.62.31.61.42.12.21.91.21.6
Sum of active levers in priming session hrs 5-61.61.53.61.1-1.9-0.30.2-1.6-1.8-0.4-0.5-1.3-1.9-0.4
Progressive ratio0.20.40.9-0.10.80.3-0.11.00.90.10.40.80.80.3
Food seeking constrained by brief footshock0.20.20.70.3-0.4-0.1-0.1-0.2-0.4-0.7-0.5-0.4-0.8-0.7
Seeking ratio, punishment vs. effort0.71.02.2-0.2-0.8-0.6-0.3-1.1-1.2-0.9-1.1-1.2-1.5-1.1
Retroperitoneal fat weight0.93.810.5-1.93.20.0-0.72.82.90.20.62.12.60.7
Reaction time number correct1.93.65.6-1.5-0.4-2.4-2.1-1.9-1.9-2.2-2.2-2.2-1.5-1.8
Reaction time mean minus median0.10.30.90.3-0.7-0.00.2-1.0-0.80.0-0.1-0.6-0.70.0
Reaction time mean minus median AUC0.20.51.60.5-0.90.10.4-1.0-1.0-0.0-0.2-0.7-1.3-0.1
Reaction time num false alarms0.40.51.61.0-1.30.30.6-0.7-0.70.70.5-0.3-0.60.7
Reaction time num false alarms AUC0.40.61.71.1-1.30.40.7-0.7-0.60.80.6-0.2-0.50.8
Reaction time trials correct on left1.93.65.6-1.5-0.4-2.4-2.1-1.9-1.9-2.2-2.2-2.2-1.5-1.8
Reaction time trials on left2.03.75.7-1.5-0.4-2.4-2.1-2.0-1.9-2.1-2.2-2.3-1.6-1.8
Reaction time mean1.62.54.51.10.31.71.61.21.42.12.01.71.62.1
Reaction time mean AUC1.82.85.61.5-0.41.91.90.81.02.42.21.51.22.3
Median of all reaction times3.14.47.11.40.42.22.01.81.92.72.62.32.12.6
Reaction time omissions0.30.51.40.3-1.0-0.00.2-1.2-1.00.3-0.0-0.7-0.80.9
Reaction time false alarm rate0.60.91.61.2-0.71.11.20.20.21.31.10.70.11.2
Reaction time premature initiation rate2.53.55.1-1.3-0.7-2.3-2.0-2.0-1.9-2.0-2.2-2.2-1.5-1.9
Reaction time premature initiations3.46.09.3-1.8-0.8-3.1-2.7-2.7-2.5-2.5-2.8-3.0-1.9-2.3
Std. dev. reaction times0.10.20.50.3-0.50.10.2-0.7-0.50.40.2-0.3-0.30.5
Reaction time trials completed2.03.75.7-1.5-0.4-2.4-2.1-2.0-1.9-2.1-2.2-2.3-1.6-1.8
Reaction time trials AUC1.63.15.1-1.5-0.3-2.3-2.0-1.7-1.6-2.0-2.0-2.0-1.3-1.7
Run reversals in cocaine runway, females1.41.44.8-2.02.2-0.8-1.20.91.0-1.1-0.90.30.3-0.9
Run reversals in cocaine runway, males1.51.53.90.9-2.0-0.6-0.2-2.0-1.90.2-0.3-1.4-1.20.2
Latency to leave start box in cocaine runway0.60.61.31.0-0.71.01.10.20.11.00.90.50.21.1
Latency to leave start box in cocaine runway, F0.00.10.10.1-0.30.30.3-0.1-0.20.10.1-0.1-0.10.3
Latency to leave start box in cocaine runway, M2.32.13.92.0-0.81.61.80.70.71.91.81.30.81.7
Std. dev. time between licks in bursts0.81.03.5-1.61.9-0.6-1.01.01.1-0.6-0.40.51.1-0.1
Total sessions with >9 infusions2.22.78.1-2.02.9-0.1-0.82.22.2-0.30.11.52.10.2
Short access day 1 total inactive lever presses2.43.18.0-1.02.50.80.02.82.80.40.92.32.00.4
Short access day 10 total inactive lever presses0.10.10.50.2-0.5-0.5-0.5-0.7-0.4-0.0-0.0-0.4-0.20.2
Short access day 1 total infusions2.53.411.7-2.63.4-0.3-1.12.42.4-1.0-0.41.41.6-0.5
Short access day 10 total infusions1.51.95.3-1.12.30.50.02.32.1-0.20.41.61.50.4
Short access total infusions2.22.87.2-1.32.70.6-0.02.62.50.10.71.92.10.7
Short access day 1 locomotion3.44.212.7-2.43.6-0.0-1.02.83.0-0.40.22.02.30.5
Short access day 10 total locomotion1.63.06.0-2.41.5-2.1-2.4-0.2-0.2-2.1-2.1-1.1-0.4-2.0
Short access total locomotion1.31.65.2-2.02.3-0.6-1.21.41.4-0.8-0.50.71.1-0.4
One hour access (0.3 mA shock)1.82.14.10.41.21.91.52.01.81.21.41.81.20.8
Compulsive drug intake1.01.22.91.7-1.41.21.6-0.2-0.21.41.10.4-0.21.0
One hour access (shock baseline)1.42.15.8-1.22.40.5-0.22.32.20.00.51.71.70.3
Social response proportion1.61.84.3-1.40.7-1.7-1.9-0.2-0.2-2.1-1.6-0.8-0.7-1.7
Social responses2.22.84.8-1.1-0.3-1.9-1.8-1.3-1.4-2.2-2.0-1.7-1.8-1.8
Social time0.30.51.9-0.0-0.6-0.6-0.5-0.7-0.8-0.5-0.7-0.7-1.4-0.2
Soleus weight0.72.13.70.11.41.10.81.81.91.21.41.81.91.3
Bone: stiffness1.93.07.8-2.82.8-1.6-2.01.31.3-1.8-1.30.30.9-1.4
Tibialis anterior weight0.62.14.4-1.50.0-2.1-2.0-1.4-1.3-1.5-1.5-1.6-0.6-1.2
Time to tail flick, vehicle, before self-admin1.21.22.10.60.81.41.01.41.20.91.11.31.11.0
Time to tail flick, vehicle, after self-admin0.91.13.0-1.11.70.1-0.51.41.40.30.30.91.70.6
Time to tail flick, test, before self-admin0.40.40.9-0.71.0-0.2-0.60.90.7-0.3-0.20.40.8-0.5
Time to tail flick, test, after self-admin2.22.33.71.8-0.61.61.71.21.01.81.91.51.41.6
Delta time to tail flick, vehicle, before/after SA0.40.40.9-1.00.4-0.8-0.9-0.2-0.1-0.5-0.7-0.40.1-0.4
Delta time to tail flick, test, before/after SA0.80.81.61.2-0.81.11.30.30.21.11.20.70.21.1
Tibia length1.02.75.7-2.42.0-1.9-2.00.30.4-2.0-1.8-0.5-0.1-2.2
Ambulatory time before self-admin0.60.93.2-1.81.6-0.8-1.00.30.5-0.9-0.8-0.10.4-0.3
Ambulatory time after self-admin1.92.25.3-2.31.2-2.0-2.0-0.7-0.5-1.8-1.7-1.2-0.3-1.2
Bone: tissue strength0.10.10.5-0.00.10.1-0.00.10.20.40.40.20.70.4
Total heroin consumption0.30.41.00.4-1.0-0.2-0.1-1.0-0.90.1-0.2-0.7-0.60.4
Bone: trabecular number2.23.67.7-2.81.6-2.4-2.6-0.5-0.3-2.4-2.2-1.3-0.4-2.1
Bone: trabecular spacing0.81.01.91.3-0.61.31.30.40.41.41.20.80.41.2
Bone: trabecular thickness2.93.67.1-2.51.4-2.3-2.4-0.4-0.4-2.7-2.3-1.3-0.8-2.4
Bone: trabecular tissue density0.20.20.60.3-0.7-0.3-0.1-0.8-0.8-0.2-0.2-0.6-0.3-0.5
Water consumed over 24 hours1.11.52.3-0.7-0.4-1.5-1.2-1.2-1.2-1.4-1.4-1.4-1.3-1.3
Number of responses in last shaping day0.30.31.0-1.01.0-0.1-0.30.50.4-0.7-0.40.1-0.1-0.6