Hub : Genes

Rab44

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative polyA	XM_006256153.3	0.03	0.03	7.6e-04	0.01	0.01	0.01	0.01	1.3e-02	1.0e-02	1.0e-02	1.0e-02
2	PL	gene expression	Rab44	0.07	0.05	2.5e-08	0.07	0.07	0.07	0.08	1.8e-08	1.2e-08	2.6e-08	9.2e-09
3	Adipose	alternative polyA	XM_039099145.1	0.03	0.03	7.6e-04	0.01	0.01	0.01	0.01	1.3e-02	9.8e-03	1.1e-02	1.1e-02
4	Adipose	gene expression	Rab44	0.1	0.09	5.5e-11	0.09	0.09	0.08	0.09	4.2e-10	4.2e-10	6.7e-09	6.9e-10
5	Brain	isoform ratio	XM_039099146.1	0.02	0.02	6.7e-03	0.01	0.01	0.01	0.01	1.8e-02	3.0e-02	5.8e-02	3.2e-02
6	OFC	gene expression	Rab44	0.35	0.29	1.6e-04	0.18	0.18	0.19	0.19	4.0e-05	3.6e-05	2.3e-05	3.4e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.6	0.9	1.8	-1.4	1.1	0.9	-0.9	-0.9	-0.5
Area under the delay curve	0.8	0.9	1.2	1.1	-1.1	-1.0	0.9	1.1	0.1
BMI with tail	1.9	6.2	10.1	3.2	-2.6	-2.5	2.4	2.4	1.6
BMI without tail	1.3	2.6	3.2	1.8	-1.7	-1.6	1.6	1.7	1.1
Body weight	6.4	26.7	31.2	5.6	-5.3	-5.2	5.2	5.2	4.5
Weight adjusted by age	1.3	1.5	4.0	2.0	-1.0	-1.1	1.1	0.9	0.8
Bone surface	0.0	0.0	0.1	0.0	0.2	-0.0	0.0	-0.1	0.3
Bone volume	0.0	0.0	0.2	-0.1	0.0	-0.1	0.2	0.1	0.4
Breakpoint value in progressive ratio session	0.2	0.3	0.3	-0.5	0.5	0.6	-0.5	-0.5	-0.4
Number of licking bursts	0.5	0.5	0.7	-0.8	0.8	0.8	-0.8	-0.6	-0.5
Context. condit. distance diff. score	0.4	0.5	1.1	-0.4	0.5	0.6	-0.7	-0.7	-1.0
Locomotion velocity, session 1	0.6	0.7	1.0	-1.0	0.8	0.8	-0.8	-0.8	-0.7
Locomotion distance, session 1	3.6	4.6	5.2	-2.1	2.2	2.1	-2.1	-2.3	-2.0
Locomotion velocity, session 2	0.3	0.3	0.4	-0.6	0.5	0.6	-0.5	-0.6	-0.5
Locomotion distance, session 2	0.9	1.2	1.4	-1.1	1.1	1.1	-1.1	-1.2	-1.1
Locomotion velocity, session 3	0.5	0.6	1.4	0.2	-0.7	-0.8	0.8	0.7	1.2
Locomotion distance, session 3	0.3	0.3	0.6	-0.8	0.4	0.5	-0.5	-0.5	-0.5
Stereotopy head waving bouts, day 3	1.9	2.3	2.7	1.4	-1.6	-1.5	1.5	1.6	1.4
Stereotopy head waving duration, day 3	0.1	0.1	0.4	0.6	-0.3	-0.4	0.3	0.3	0.2
Locomotion velocity, session 7	0.1	0.1	0.4	-0.7	0.1	0.1	-0.1	-0.1	0.1
Locomotion distance, session 7	0.9	1.1	2.1	-1.5	0.9	1.0	-1.0	-0.9	-0.9
Stereotopy head waving bouts, day 7	0.5	0.6	0.9	0.4	-0.7	-0.8	0.8	0.8	0.9
Stereotopy head waving duration, day 7	1.3	1.6	2.4	0.9	-1.2	-1.3	1.3	1.3	1.6
Locomotion velocity, session 8	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.1	-0.2	-0.4
Locomotion distance, session 8	0.9	1.4	1.6	-1.1	1.1	1.1	-1.2	-1.2	-1.2
Degree of sensitization distance	0.0	0.0	0.1	0.1	0.0	0.1	-0.1	-0.1	-0.2
Degree of sensitization stereotypy	0.1	0.1	0.2	-0.4	0.0	-0.1	0.1	0.2	0.5
Conditioned locomotion	2.8	3.3	3.9	1.5	-1.9	-1.8	1.9	1.8	2.0
Cocaine response after cond. corrected	0.8	0.8	2.8	1.7	-0.8	-0.8	0.8	0.6	0.2
Cocaine response after cond. not corrected	0.7	0.8	2.3	1.5	-0.9	-0.8	0.8	0.7	0.1
Cocaine response before conditioning	0.1	0.1	0.2	-0.5	-0.2	-0.0	0.1	0.4	0.1
Saline control response	0.6	0.8	1.2	0.8	-1.1	-0.9	0.9	1.0	0.6
Bone: connectivity density	0.5	0.7	1.2	-1.1	1.1	0.8	-0.8	-0.8	-0.1
Bone: cortical apparent density	0.0	0.1	0.2	-0.4	0.0	-0.0	0.1	-0.1	0.4
Bone: cortical area	0.3	0.5	1.3	1.1	-0.7	-0.6	0.6	0.6	-0.1
Bone: cortical porosity	0.0	0.0	0.1	0.3	-0.0	-0.0	0.0	0.0	-0.1
Bone: cortical porosity	0.0	0.0	0.1	0.2	0.0	0.0	-0.1	-0.0	-0.2
Bone: cortical thickness	0.1	0.2	0.7	-0.1	0.2	0.4	-0.4	-0.2	-0.8
Bone: cortical thickness	0.0	0.0	0.1	0.0	-0.3	-0.1	0.1	0.3	-0.0
Bone: cortical tissue density	0.0	0.1	0.2	-0.3	-0.1	-0.1	0.2	-0.0	0.5
Condit. Reinf. active minus inactive responses	0.9	1.0	1.2	-1.1	1.1	1.0	-0.9	-1.0	-0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.2	0.4	0.3	-0.3	-0.3	-0.3
Condit. Reinf. active responses	0.2	0.3	0.7	-0.8	0.5	0.4	-0.4	-0.4	-0.1
Condit. Reinf. inactive responses	0.2	0.3	1.0	-1.0	0.4	0.4	-0.4	-0.3	0.1
Incentive salience index mean	0.3	0.4	0.5	-0.7	0.7	0.6	-0.6	-0.6	-0.3
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.1	0.3	0.2	-0.2	-0.2	-0.1
Condit. Reinf. active minus inactive responses	0.6	0.8	1.1	-0.9	1.1	0.9	-0.9	-0.8	-0.6
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.6	-0.3	0.8	0.5	-0.5	-0.4	-0.2
Condit. Reinf. active responses	0.6	0.8	1.1	-1.1	1.0	0.9	-0.9	-0.7	-0.8
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.2	-0.3	-0.2	0.2	0.3	0.1
Condit. Reinf. lever presses	3.9	5.2	6.4	-2.3	2.1	2.3	-2.3	-2.1	-2.5
Condit. Reinf. lever reinforcers received	1.3	1.9	2.2	-1.5	1.4	1.4	-1.4	-1.2	-1.3
Conditioned reinforcement - actives	0.6	0.6	0.8	0.9	-0.8	-0.8	0.8	0.8	0.7
Conditioned reinforcement - inactives	0.1	0.1	0.3	-0.6	0.2	0.4	-0.3	-0.2	-0.3
Conditioned locomotion	0.6	0.7	0.9	0.9	-0.9	-0.9	0.8	0.9	0.7
Patch foraging indifference point 0 sec	0.3	0.5	0.6	0.6	-0.8	-0.7	0.7	0.8	0.6
Patch foraging indifference point AUC	0.0	0.0	0.2	-0.4	0.1	0.1	-0.1	-0.2	-0.1
Delay disc. indifference point, 0s delay	0.3	0.3	1.7	1.3	-0.2	-0.3	0.2	0.2	-0.4
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	-0.0	-0.5	-0.4	0.4	0.5	0.0
Delay disc. indifference point, 2s delay	0.2	0.2	0.8	0.1	0.3	0.3	-0.4	-0.2	-0.9
Delay disc. indifference point, 24s delay	2.3	2.2	2.7	1.5	-1.6	-1.6	1.5	1.6	0.9
Delay disc. indifference point, 4s delay	1.1	1.2	1.7	1.3	-1.2	-1.1	1.1	1.2	0.4
Delay disc. indifference point, 8s delay	1.7	1.8	2.5	1.3	-1.6	-1.4	1.3	1.6	0.7
Indifference point function ln k	0.1	0.1	0.2	-0.1	0.5	0.4	-0.3	-0.4	-0.3
Indifference point function log k	0.1	0.1	0.2	-0.1	0.5	0.4	-0.3	-0.4	-0.3
Patch foraging total patch changes 0 sec	0.2	0.4	0.5	0.6	-0.7	-0.6	0.6	0.7	0.5
Patch foraging total patch changes 12 sec	0.0	0.0	0.1	-0.0	-0.1	0.1	-0.1	0.0	-0.4
Patch foraging total patch changes 18 sec	0.5	0.7	1.3	0.4	-1.1	-0.9	0.9	0.9	0.6
Patch foraging total patch changes 24 sec	0.4	0.5	0.9	-0.6	0.6	0.7	-0.7	-0.6	-0.9
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	0.1	-0.2	-0.2	0.2	0.2	0.1
Patch foraging time to switch 0 sec	1.1	1.6	2.7	1.6	-1.2	-1.3	1.3	1.3	0.9
Patch foraging water rate 0 sec	0.2	0.3	0.5	-0.4	0.6	0.6	-0.6	-0.7	-0.5
Patch foraging water rate 12 sec	0.2	0.2	0.3	-0.5	0.5	0.5	-0.5	-0.5	-0.5
Patch foraging water rate 18 sec	0.5	0.7	1.3	-1.1	0.9	0.8	-0.8	-0.8	-0.6
Patch foraging water rate 24 sec	0.4	0.5	0.9	-0.7	0.6	0.7	-0.7	-0.6	-1.0
Patch foraging water rate 6 sec	0.2	0.2	0.6	-0.4	0.4	0.5	-0.5	-0.4	-0.8
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.8	-0.9	-0.1	-0.0	0.1	0.1	0.3
Distance traveled before self-admin	0.9	1.0	1.3	1.2	-1.0	-0.9	1.0	1.0	1.0
Distance traveled after self-admin	0.2	0.2	0.5	0.3	-0.3	-0.3	0.3	0.4	0.7
Extensor digitorum longus weight	0.2	0.7	0.8	-0.8	0.8	0.9	-0.9	-0.9	-0.8
Bone: elastic displacement	0.0	0.0	0.1	-0.2	0.2	0.2	-0.2	-0.2	-0.1
Bone: elastic work	0.0	0.0	0.1	0.3	-0.2	-0.1	0.1	0.2	-0.3
Bone: endosteal estimation	3.3	7.1	8.2	2.9	-2.7	-2.7	2.7	2.6	2.3
Bone: endosteal perimeter	1.8	3.7	5.9	2.4	-1.8	-2.0	1.9	1.7	1.6
Epididymis fat weight	1.5	3.5	5.7	2.4	-1.9	-1.9	1.8	1.9	1.3
Delta time in closed arm before/after self-admin	1.9	1.8	3.7	1.9	-1.2	-1.3	1.2	1.2	1.0
Delta time in open arm before/after self-admin	0.9	0.8	1.0	-1.0	0.9	0.9	-0.9	-0.9	-0.9
Diff in mean of infusions in LGA sessions	0.9	1.0	1.2	-0.9	1.1	1.0	-1.0	-1.1	-0.9
Delay discount exponential model param	0.6	0.7	1.0	-0.8	1.0	0.9	-0.8	-1.0	-0.1
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.2	0.4	0.4	-0.4	-0.4	-0.4
Active lever presses in extinction session 6	0.0	0.0	0.1	0.3	-0.0	-0.1	0.1	-0.0	-0.3
Bone: final force	4.2	6.8	8.1	2.8	-2.7	-2.7	2.6	2.6	2.2
Bone: final moment	3.4	5.6	6.9	2.6	-2.5	-2.4	2.4	2.4	1.7
Food consumed during 24 hour testing period	0.5	0.6	1.0	1.0	-0.7	-0.7	0.7	0.8	0.5
Glucose	0.1	0.2	0.6	0.8	-0.0	-0.0	-0.0	0.0	-0.6
Heart weight	2.2	3.1	3.7	-1.3	1.9	1.9	-1.9	-1.9	-1.7
Delay discount hyperbolic model param	0.4	0.4	0.6	-0.7	0.8	0.7	-0.6	-0.8	0.1
Intermittent access intake day 1-15 change	1.0	1.0	2.2	0.0	-1.0	-0.9	1.0	1.0	1.5
Intermittent access intake escalation	1.6	1.5	3.1	0.3	-1.2	-1.2	1.3	1.2	1.7
Intermittent access intake escalation 2	0.3	0.3	0.8	-0.9	0.1	0.1	-0.0	-0.1	0.8
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.3	0.5	0.2	0.2	-0.2	-0.2	-0.2
Intermitt. access day 15 inactive lever presses	1.5	1.6	2.7	0.6	-1.3	-1.2	1.3	1.3	1.7
Intermitt. access escalation Index	0.5	0.4	0.5	-0.6	0.7	0.6	-0.6	-0.7	-0.6
Intermittent access day 1 total infusions	0.3	0.3	0.5	-0.7	0.5	0.6	-0.6	-0.5	-0.6
Intermittent access day 15 total infusions	0.1	0.2	0.4	-0.2	-0.4	-0.3	0.4	0.4	0.6
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.6	0.3	-0.5	-0.5	0.5	0.5	0.8
Intermittent access total infusions	0.0	0.0	0.2	-0.4	0.1	0.2	-0.1	-0.1	0.0
Intermittent access day 1 locomotion	0.2	0.2	0.3	0.4	-0.5	-0.4	0.4	0.5	0.4
Intermittent access day 15 total locomotion	5.3	5.7	7.6	1.5	-2.5	-2.4	2.4	2.5	2.8
Intermittent access total locomotion	2.0	2.3	3.1	0.7	-1.7	-1.5	1.5	1.7	1.7
Intermittent access standard deviation	1.0	1.1	1.4	1.0	-1.0	-1.0	1.0	1.0	1.2
Left kidney weight	3.1	8.8	9.6	3.1	-2.9	-3.0	3.0	2.8	3.1
Right kidney weight	4.0	11.3	11.5	3.3	-3.4	-3.4	3.4	3.4	3.3
Cocaine induced anxiety	0.1	0.1	0.5	-0.7	0.1	0.2	-0.1	-0.1	0.2
Post-drug Anxiety	0.3	0.3	0.6	-0.8	0.5	0.5	-0.5	-0.5	-0.1
Baseline Anxiety	0.3	0.3	0.6	0.2	0.6	0.5	-0.6	-0.6	-0.8
Tail length	1.3	3.8	4.7	1.5	-2.0	-1.9	2.0	2.1	2.2
Length with tail	2.5	9.3	10.9	2.7	-3.0	-3.1	3.1	3.1	3.3
Length without tail	1.8	4.0	4.4	2.1	-2.0	-2.0	2.0	1.9	2.0
Times rat made contact with spout	2.9	3.3	5.0	-2.2	1.8	1.8	-1.8	-1.8	-1.4
Lifetime Intake	0.1	0.1	0.1	0.1	-0.3	-0.2	0.2	0.3	0.3
Liver weight, left	5.3	8.5	10.4	2.1	-3.2	-3.0	3.0	3.0	3.0
Liver weight, right	2.6	4.3	5.1	1.6	-2.3	-2.1	2.1	2.1	2.1
Locomotor activity	0.1	0.2	0.3	0.0	-0.6	-0.4	0.4	0.5	0.3
Locomotor testing distance	0.0	0.0	0.2	0.1	-0.2	-0.0	-0.0	0.1	-0.4
Locomotor testing rearing	1.0	1.5	2.1	1.2	-1.4	-1.2	1.2	1.3	0.8
Locomotion in novel chamber	0.6	0.8	2.2	-0.4	0.7	0.8	-0.9	-0.7	-1.5
Locomotion in novel chamber post-restriction	1.7	2.1	2.4	1.4	-1.5	-1.5	1.5	1.5	1.2
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	-0.0	-0.1	-0.0	0.0	0.1	-0.2
Change in fecal boli incidents, locomotor task	0.7	0.6	3.3	1.8	-0.3	-0.3	0.3	0.3	-0.3
Time >=10cm from walls, locomotor time 1	1.6	1.7	2.8	1.7	-1.1	-1.3	1.3	1.1	1.2
Bouts of movement, locomotor time 1	0.2	0.2	0.3	-0.6	0.5	0.5	-0.5	-0.5	-0.5
Total resting periods, locomotor time 1	0.0	0.0	0.2	-0.4	0.1	0.2	-0.2	-0.1	-0.2
Rest time, locomotor task time 1	0.2	0.2	0.6	0.8	-0.3	-0.4	0.4	0.3	0.3
Distance moved, locomotor task time 1	0.1	0.1	0.4	0.0	-0.3	-0.4	0.4	0.3	0.6
Vertical activity count, locomotor time 1	0.5	0.6	0.8	0.5	-0.7	-0.8	0.8	0.7	0.9
Time >=10cm from walls, locomotor time 2	6.4	6.8	12.9	3.6	-2.4	-2.5	2.5	2.4	2.0
Bouts of movement, locomotor time 2	0.1	0.1	0.2	-0.4	-0.3	-0.3	0.4	0.3	0.4
Total resting periods, locomotor time 2	0.1	0.1	0.4	-0.6	0.2	0.2	-0.2	-0.2	-0.2
Rest time, locomotor task time 2	0.0	0.0	0.2	0.4	-0.1	-0.0	-0.0	0.1	-0.3
Distance moved, locomotor task time 2	2.5	2.8	4.4	1.4	-1.6	-1.7	1.7	1.6	2.1
Vertical activity count, locomotor time 2	1.6	1.7	3.8	1.1	-1.1	-1.3	1.3	1.1	1.9
Light reinforcement 1	2.1	3.8	4.3	2.0	-2.0	-2.0	1.9	2.1	1.7
Light reinforcement 2	2.4	3.2	3.5	1.8	-1.8	-1.9	1.8	1.7	1.7
Bone: marrow area	3.4	7.3	8.4	2.9	-2.8	-2.8	2.7	2.6	2.4
Bone: maximum diameter	0.4	0.7	1.8	1.4	-0.8	-0.8	0.8	0.8	0.4
Bone: maximum force	1.5	2.7	3.3	1.8	-1.6	-1.7	1.7	1.6	1.3
Bone: maximum moment	1.1	1.9	2.5	1.6	-1.5	-1.4	1.4	1.4	0.9
Mean time between licks in bursts	0.5	0.8	1.2	-0.9	1.1	0.9	-0.8	-1.0	-0.5
Mean num. licks in bursts	0.2	0.3	0.5	-0.7	0.5	0.5	-0.5	-0.6	-0.4
Cd content in liver	1.1	1.2	1.8	0.7	-1.0	-1.1	1.1	1.2	1.3
Co content in liver	2.3	2.7	3.2	1.8	-1.5	-1.7	1.7	1.6	1.7
Cu content in liver	3.4	4.2	5.0	-2.0	2.1	2.1	-2.0	-2.2	-1.8
Fe content in liver	4.3	5.1	6.8	1.9	-2.1	-2.3	2.4	2.2	2.6
K content in liver	1.2	1.2	1.9	-0.8	1.4	1.1	-1.1	-1.4	-0.7
Mg content in liver	2.6	2.6	3.4	-1.1	1.8	1.7	-1.7	-1.8	-1.6
Mn content in liver	0.1	0.1	0.4	-0.0	0.4	0.3	-0.3	-0.6	-0.1
Na content in liver	0.2	0.2	0.5	-0.4	0.5	0.2	-0.1	-0.2	0.7
Rb content in liver	0.2	0.2	0.4	0.6	-0.5	-0.4	0.4	0.5	0.1
Se content in liver	2.7	3.3	4.5	-1.6	2.1	1.9	-1.9	-2.0	-1.4
Sr content in liver	0.0	0.0	0.0	-0.0	0.1	0.2	-0.2	-0.1	-0.2
Zn content in liver	1.1	1.2	3.7	1.9	-1.2	-0.8	0.7	0.9	-0.5
Bone: minimum diameter	1.3	2.4	5.2	2.3	-1.5	-1.5	1.4	1.4	0.7
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.1	-0.0	-0.4
Time in novel zone, hab. session 1	0.3	0.3	0.4	0.7	-0.4	-0.6	0.6	0.5	0.7
Total zone transitions, hab. session 1	2.5	3.5	4.3	-2.1	1.9	1.9	-1.9	-1.9	-1.5
Total locomotion distance, hab. session 1	1.8	2.6	2.8	-1.7	1.6	1.6	-1.6	-1.7	-1.4
Locomotion velocity, hab. session 1	1.7	2.4	2.6	-1.5	1.5	1.6	-1.6	-1.6	-1.4
Time in familiar zone, hab. session 2	1.4	1.5	2.0	-1.2	1.1	1.2	-1.2	-1.2	-1.4
Time in novel zone, hab. session 2	1.5	1.5	2.0	1.1	-1.1	-1.3	1.3	1.2	1.4
Total zone transitions, hab. session 2	0.4	0.5	0.7	-0.7	0.8	0.7	-0.7	-0.8	-0.6
Total locomotion distance, hab. session 2	2.5	3.3	3.6	-1.8	1.8	1.8	-1.8	-1.9	-1.7
Locomotion velocity, hab. session 2	2.9	3.9	4.3	-2.0	2.0	2.0	-2.0	-2.1	-1.9
Novel to familiar place preference ratio	0.4	0.4	1.1	1.0	-0.6	-0.6	0.5	0.6	0.3
Novelty place preference	0.4	0.4	0.8	0.9	-0.5	-0.5	0.5	0.6	0.3
Time in novel zone, NPP test	0.4	0.4	0.9	0.9	-0.6	-0.6	0.6	0.7	0.4
Total zone transitions, NPP test	1.7	2.4	2.8	-1.4	1.6	1.5	-1.6	-1.7	-1.6
Total locomotion distance, NPP test	1.4	1.9	2.4	-1.2	1.3	1.4	-1.4	-1.4	-1.5
Locomotion velocity, NPP test	2.1	3.0	3.5	-1.5	1.7	1.7	-1.8	-1.8	-1.9
Intraocular pressure	1.0	1.4	1.8	1.1	-1.3	-1.3	1.3	1.2	1.0
Delta distance traveled before/after self-admin	0.5	0.5	0.7	-0.8	0.8	0.8	-0.7	-0.7	-0.4
Delta ambulatory time before/after self-admin	0.6	0.7	1.3	-1.1	0.8	0.9	-0.8	-0.8	-0.4
Parametrial fat weight	2.1	4.0	4.8	1.2	-2.2	-2.0	2.1	2.2	2.2
Pavlov. Cond. lever latency	0.3	0.4	0.6	0.5	-0.8	-0.7	0.7	0.6	0.5
Pavlov. Cond. magazine entry latency	0.6	0.7	1.5	-0.6	0.8	0.8	-0.8	-0.9	-1.2
Pavlov. Cond. change in total contacts	0.5	0.5	0.6	0.7	-0.7	-0.8	0.8	0.7	0.7
Pavlov. Cond. index score	0.2	0.3	0.7	-0.1	0.5	0.5	-0.5	-0.5	-0.8
Pavlov. Cond. latency score	0.2	0.2	0.7	0.0	0.4	0.4	-0.4	-0.4	-0.8
Pavlov. Cond. lever contacts	0.3	0.3	0.4	-0.4	0.6	0.6	-0.6	-0.6	-0.6
Pavlov. Cond. magazine entry number	1.0	1.3	1.8	0.8	-1.2	-1.1	1.1	1.2	1.3
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	-0.4	0.1	0.1	0.0	0.0	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.6	-0.1	0.4	0.4	-0.4	-0.4	-0.8
Pavlov. Cond. response bias	1.0	1.3	1.4	-1.0	1.2	1.1	-1.1	-1.2	-1.2
Pavlov. Cond. lever latency	2.3	3.1	4.1	2.0	-1.5	-1.7	1.7	1.5	2.0
Pavlov. Cond. magazine entry latency	0.1	0.2	0.3	0.0	-0.5	-0.4	0.4	0.5	0.4
Pavlov. Cond. change in total contacts	1.4	1.9	2.7	-1.6	1.3	1.4	-1.4	-1.2	-1.5
Pavlov. Cond. index score	0.5	0.7	1.4	-1.2	0.7	0.8	-0.8	-0.7	-0.8
Pavlov. Cond. latency score	0.3	0.4	0.9	-0.9	0.5	0.6	-0.6	-0.5	-0.6
Pavlov. Cond. lever contacts	1.6	2.1	3.6	-1.9	1.1	1.4	-1.4	-1.2	-1.6
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.2	0.3	0.2	-0.2	-0.2	-0.1
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.1	-0.8	1.1	0.8	-0.8	-0.8	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.9	-1.0	0.4	0.5	-0.6	-0.4	-0.6
Pavlov. Cond. response bias	0.9	1.3	2.6	-1.6	0.8	1.0	-1.0	-0.8	-1.2
Time in closed arm before self-admin	0.3	0.4	0.6	-0.1	0.8	0.7	-0.7	-0.7	-0.6
Time in closed arm after self-admin	0.2	0.2	0.8	0.9	-0.1	-0.2	0.2	0.1	0.1
Time in open arm before self-admin	0.4	0.4	1.9	-1.4	0.4	0.5	-0.4	-0.3	-0.0
Time in open arm after self-admin	2.0	2.2	4.9	-2.2	1.3	1.4	-1.4	-1.3	-1.1
Bone: periosteal estimation	2.1	4.4	6.3	2.5	-2.1	-2.1	2.1	2.1	1.5
Bone: periosteal perimeter	0.8	1.4	2.9	1.7	-1.1	-1.2	1.1	1.1	0.6
Bone: post-yield work	0.2	0.3	0.4	0.6	-0.4	-0.5	0.5	0.5	0.6
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	0.2	-0.0	0.1	-0.1	-0.0	-0.4
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.3	0.1	0.2	-0.2	-0.1	-0.4
Progressive ratio test 1 inactive lever presses	0.9	1.0	1.2	0.9	-1.1	-1.0	1.0	1.1	1.0
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.1	-0.0	-0.0	0.0	0.0	0.2
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	-0.2	0.1	0.1	-0.1	-0.1	0.1
Progressive ratio test 2 inactive lever presses	0.2	0.3	0.9	-0.9	0.4	0.4	-0.3	-0.4	0.4
Incentive Sensitization - Responses	0.9	0.9	1.6	-1.3	0.9	0.9	-0.9	-1.0	-0.6
Incentive Sensitization - Breakpoint	0.5	0.5	1.3	-1.1	0.7	0.7	-0.6	-0.7	-0.3
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.4	-0.3	0.6	0.6	-0.6	-0.6	-0.4
Progressive ratio	3.2	3.7	5.5	0.9	-2.0	-2.0	2.0	1.9	2.3
Food seeking constrained by brief footshock	0.1	0.1	0.3	-0.2	0.3	0.3	-0.3	-0.4	-0.6
Seeking ratio, punishment vs. effort	2.3	2.8	4.7	-0.4	1.7	1.7	-1.7	-1.7	-2.2
Retroperitoneal fat weight	1.4	4.5	6.7	2.6	-2.2	-2.1	2.1	2.1	1.6
Reaction time number correct	0.6	0.8	1.2	0.3	-1.0	-1.0	1.0	1.1	1.0
Reaction time mean minus median	0.2	0.3	0.8	-0.4	-0.4	-0.5	0.5	0.4	0.9
Reaction time mean minus median AUC	0.1	0.2	0.3	-0.2	-0.4	-0.4	0.4	0.4	0.5
Reaction time num false alarms	0.1	0.1	0.3	-0.5	0.2	0.3	-0.3	-0.3	-0.1
Reaction time num false alarms AUC	0.5	0.7	0.9	-0.9	0.7	0.9	-0.9	-0.9	-0.6
Reaction time trials correct on left	0.6	0.8	1.2	0.3	-1.0	-1.0	1.0	1.1	1.0
Reaction time trials on left	0.6	0.8	1.1	0.3	-1.0	-0.9	1.0	1.1	0.9
Reaction time mean	0.2	0.2	0.3	0.5	-0.5	-0.5	0.5	0.4	0.4
Reaction time mean AUC	0.4	0.6	0.7	0.6	-0.8	-0.8	0.8	0.7	0.7
Median of all reaction times	0.2	0.3	0.7	0.8	-0.5	-0.6	0.5	0.4	0.3
Reaction time omissions	0.1	0.1	0.3	-0.5	-0.0	-0.1	0.2	0.1	0.5
Reaction time false alarm rate	1.2	1.6	2.1	-1.0	1.3	1.4	-1.4	-1.4	-1.2
Reaction time premature initiation rate	0.1	0.1	0.3	-0.2	0.5	0.4	-0.4	-0.5	-0.1
Reaction time premature initiations	0.1	0.1	0.4	0.2	-0.3	-0.3	0.3	0.3	0.6
Std. dev. reaction times	0.0	0.1	0.2	-0.3	-0.1	-0.2	0.2	0.1	0.4
Reaction time trials completed	0.6	0.8	1.1	0.3	-1.0	-0.9	1.0	1.1	0.9
Reaction time trials AUC	0.6	0.8	1.1	0.3	-1.0	-0.9	1.0	1.0	1.0
Run reversals in cocaine runway, females	0.2	0.1	0.3	-0.1	-0.5	-0.4	0.4	0.5	0.1
Run reversals in cocaine runway, males	0.7	0.7	1.8	-1.2	-0.5	-0.4	0.5	0.6	1.4
Latency to leave start box in cocaine runway	0.6	0.7	1.0	0.6	1.0	0.7	-0.8	-1.0	-0.9
Latency to leave start box in cocaine runway, F	0.7	0.8	1.1	0.6	1.0	0.7	-0.8	-1.0	-1.1
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.2	0.2	0.1	-0.1	-0.1	0.0
Std. dev. time between licks in bursts	0.5	0.6	2.6	1.6	-0.4	-0.4	0.3	0.2	-0.5
Total sessions with >9 infusions	0.1	0.1	0.3	0.5	-0.2	-0.1	0.1	0.2	-0.3
Short access day 1 total inactive lever presses	0.1	0.1	0.1	-0.2	0.3	0.2	-0.2	-0.3	0.2
Short access day 10 total inactive lever presses	0.0	0.0	0.1	-0.0	-0.3	-0.1	0.1	0.3	0.3
Short access day 1 total infusions	0.8	0.9	1.0	-0.6	1.0	1.0	-1.0	-0.9	-1.0
Short access day 10 total infusions	0.0	0.0	0.0	-0.1	0.0	0.1	-0.1	-0.0	0.1
Short access total infusions	0.0	0.0	0.1	0.4	-0.1	-0.1	0.0	0.1	0.0
Short access day 1 locomotion	0.2	0.2	0.6	0.6	0.1	0.3	-0.3	-0.1	-0.8
Short access day 10 total locomotion	0.4	0.5	0.7	0.6	0.6	0.7	-0.7	-0.6	-0.9
Short access total locomotion	0.1	0.2	0.9	1.0	-0.1	-0.0	0.0	0.1	-0.1
One hour access (0.3 mA shock)	0.8	0.9	1.4	-1.2	1.0	1.0	-1.0	-1.0	-0.7
Compulsive drug intake	2.6	2.7	3.4	-0.7	1.8	1.7	-1.7	-1.8	-1.7
One hour access (shock baseline)	0.3	0.4	0.8	-0.5	-0.6	-0.5	0.6	0.6	0.9
Social response proportion	0.1	0.1	0.4	0.6	-0.0	-0.0	-0.0	-0.0	-0.5
Social responses	0.1	0.2	0.7	0.5	0.1	0.3	-0.3	-0.3	-0.8
Social time	0.1	0.2	0.3	-0.5	0.4	0.5	-0.4	-0.3	-0.4
Soleus weight	0.3	1.0	2.6	1.6	-0.9	-0.9	0.8	0.8	0.5
Bone: stiffness	1.2	1.9	2.1	1.5	-1.5	-1.4	1.4	1.4	1.1
Tibialis anterior weight	0.8	2.8	3.5	-1.3	1.7	1.8	-1.8	-1.7	-1.9
Time to tail flick, vehicle, before self-admin	2.1	2.2	2.9	0.5	-1.6	-1.5	1.6	1.6	1.7
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.3	0.1	0.4	0.4	-0.4	-0.4	-0.6
Time to tail flick, test, before self-admin	0.1	0.1	0.2	-0.4	0.3	0.3	-0.3	-0.3	-0.2
Time to tail flick, test, after self-admin	0.3	0.3	1.4	-1.2	-0.1	-0.0	0.1	0.1	0.4
Delta time to tail flick, vehicle, before/after SA	1.5	1.5	2.6	-0.4	1.3	1.2	-1.2	-1.3	-1.6
Delta time to tail flick, test, before/after SA	1.4	1.2	1.6	0.4	-1.3	-1.2	1.2	1.2	1.1
Tibia length	2.7	7.7	10.4	2.4	-2.6	-2.8	2.9	2.6	3.2
Ambulatory time before self-admin	0.5	0.5	0.6	0.8	-0.7	-0.6	0.7	0.7	0.7
Ambulatory time after self-admin	0.1	0.1	0.4	-0.6	0.3	0.4	-0.3	-0.2	0.2
Bone: tissue strength	0.0	0.0	0.0	-0.1	-0.0	0.0	-0.0	0.0	-0.1
Total heroin consumption	0.5	0.5	1.6	-1.2	0.6	0.7	-0.7	-0.6	0.1
Bone: trabecular number	1.1	1.6	2.7	-1.6	1.4	1.3	-1.2	-1.2	-0.8
Bone: trabecular spacing	1.9	2.5	3.2	1.7	-1.8	-1.6	1.6	1.5	1.2
Bone: trabecular thickness	0.3	0.4	0.6	0.1	-0.7	-0.6	0.7	0.7	0.8
Bone: trabecular tissue density	0.1	0.1	0.3	-0.2	-0.1	-0.2	0.3	0.2	0.6
Water consumed over 24 hours	1.3	1.5	1.8	-0.9	1.4	1.3	-1.3	-1.2	-1.3
Number of responses in last shaping day	0.9	0.9	1.2	0.7	1.0	1.0	-1.0	-1.0	-1.1