Hub : Genes

Rab40b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	IC	gene expression	Rab40b	0.2	0.1	5.5e-03	-0.01	0.01	-0	-0	7.4e-01	1.4e-01	4.9e-01	4.9e-01
2	Liver	gene expression	Rab40b	0.19	0.07	1.2e-13	0.12	0.11	0.12	0.12	1.9e-13	2.0e-12	3.2e-13	6.1e-13
3	OFC	gene expression	Rab40b	0.27	0.13	2.9e-03	0.01	0.04	0.02	0.03	1.8e-01	3.2e-02	9.2e-02	8.1e-02
4	Brain	mRNA stability	Rab40b	0.1	0.05	5.8e-07	0.04	0.07	0.07	0.06	1.2e-04	5.0e-07	9.9e-07	2.1e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.0	0.1	0.2	-0.1	-0.4	0.3	-0.2
Area under the delay curve	0.3	0.4	0.9	1.0	0.3	0.5	-0.4
BMI with tail	0.8	2.9	5.9	-2.4	1.6	-1.3	1.2
BMI without tail	0.2	0.5	1.3	-1.1	-0.8	0.2	-0.4
Body weight	1.2	5.3	13.2	-3.6	1.6	-1.9	1.4
Weight adjusted by age	1.1	1.7	4.5	-2.1	0.5	-1.1	1.0
Bone surface	0.2	0.3	0.7	-0.5	-0.8	0.2	-0.4
Bone volume	0.1	0.2	0.5	-0.3	-0.7	0.3	-0.4
Breakpoint value in progressive ratio session	1.4	1.6	2.6	-1.6	1.3	-1.3	0.8
Number of licking bursts	0.4	0.6	0.8	0.8	-0.9	0.8	-0.7
Context. condit. distance diff. score	2.6	3.1	4.7	1.2	-2.2	1.7	-1.8
Locomotion velocity, session 1	1.8	1.9	3.2	-0.5	1.8	-1.4	1.5
Locomotion distance, session 1	0.2	0.3	0.4	0.5	0.6	0.6	-0.5
Locomotion velocity, session 2	0.3	0.4	0.9	0.7	0.9	0.1	0.0
Locomotion distance, session 2	0.2	0.2	0.4	0.3	0.3	0.6	-0.5
Locomotion velocity, session 3	0.5	0.6	1.6	0.1	1.3	-0.5	0.8
Locomotion distance, session 3	0.4	0.4	1.3	0.7	1.1	0.1	0.1
Stereotopy head waving bouts, day 3	0.9	1.0	1.7	-0.9	1.3	-0.9	0.9
Stereotopy head waving duration, day 3	0.4	0.5	1.0	-0.7	1.0	-0.5	0.5
Locomotion velocity, session 7	0.7	0.7	0.9	0.9	-0.9	0.8	-0.8
Locomotion distance, session 7	2.8	3.6	6.1	2.5	-1.1	2.0	-1.8
Stereotopy head waving bouts, day 7	0.5	0.5	1.6	-1.3	0.5	-0.5	0.2
Stereotopy head waving duration, day 7	0.3	0.4	1.2	-1.1	0.3	-0.4	0.3
Locomotion velocity, session 8	0.2	0.2	0.4	0.4	-0.1	0.7	-0.3
Locomotion distance, session 8	2.6	3.7	5.1	1.3	-1.8	2.3	-2.2
Degree of sensitization distance	1.8	1.9	3.4	1.1	-1.8	1.2	-1.2
Degree of sensitization stereotypy	0.2	0.2	0.7	-0.9	0.1	-0.2	-0.0
Conditioned locomotion	0.7	0.8	2.1	-0.2	-1.5	0.6	-0.7
Cocaine response after cond. corrected	0.6	0.7	1.4	-0.2	1.2	-0.8	0.8
Cocaine response after cond. not corrected	0.3	0.4	1.1	0.2	1.1	-0.4	0.4
Cocaine response before conditioning	1.0	1.2	1.6	1.1	-0.8	1.2	-1.3
Saline control response	0.5	0.7	2.0	0.7	-1.4	0.5	-0.3
Bone: connectivity density	0.6	1.0	1.5	0.8	-1.2	1.1	-0.9
Bone: cortical apparent density	0.4	0.6	2.0	1.4	0.5	0.3	0.0
Bone: cortical area	8.3	12.7	24.6	-5.0	3.0	-3.0	2.9
Bone: cortical porosity	4.1	4.4	6.0	-2.4	1.9	-2.2	1.8
Bone: cortical porosity	3.4	3.7	5.3	-2.3	1.6	-2.0	1.7
Bone: cortical thickness	12.9	21.5	29.1	-5.4	4.6	-4.2	4.3
Bone: cortical thickness	5.3	6.2	7.5	-2.6	2.7	-2.3	2.4
Bone: cortical tissue density	0.5	0.7	2.6	1.6	0.4	0.4	-0.0
Condit. Reinf. active minus inactive responses	0.3	0.4	1.1	-1.0	-0.0	-0.5	0.5
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.4	-1.2	0.6	-0.7	0.8
Condit. Reinf. active responses	0.2	0.3	0.7	-0.8	-0.5	-0.2	0.1
Condit. Reinf. inactive responses	0.3	0.4	1.1	0.3	-1.0	0.4	-0.5
Incentive salience index mean	0.1	0.1	0.4	-0.6	-0.4	-0.0	-0.0
Condit. Reinf. lever presses	0.7	1.0	1.3	0.9	-0.9	1.0	-1.1
Condit. Reinf. active minus inactive responses	1.0	1.3	2.8	-1.7	0.9	-0.9	0.9
Condit. Reinf. active-inactive response ratio	2.7	3.1	5.6	-2.4	1.3	-1.6	1.6
Condit. Reinf. active responses	0.2	0.3	0.8	-0.9	0.4	-0.2	0.3
Condit. Reinf. inactive responses	0.2	0.3	0.4	0.7	-0.2	0.7	-0.5
Condit. Reinf. lever presses	0.2	0.3	0.4	0.4	-0.4	0.7	-0.6
Condit. Reinf. lever reinforcers received	0.1	0.1	0.5	-0.7	0.1	0.0	-0.0
Conditioned reinforcement - actives	0.4	0.6	1.2	1.1	-0.1	0.8	-0.8
Conditioned reinforcement - inactives	0.0	0.0	0.1	0.3	0.1	0.1	-0.2
Conditioned locomotion	0.4	0.5	0.8	0.5	0.0	0.9	-0.9
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.4	-0.7	0.2	-0.1
Patch foraging indifference point AUC	0.2	0.3	0.5	0.7	-0.7	0.5	-0.5
Delay disc. indifference point, 0s delay	0.3	0.3	0.6	-0.4	0.8	-0.3	0.5
Delay disc. indifference point, 16s delay	2.0	2.2	3.0	1.7	-0.7	1.7	-1.6
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	-0.1	0.4	-0.1	0.1
Delay disc. indifference point, 24s delay	0.4	0.5	1.5	0.4	1.2	-0.3	0.4
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	0.5	0.6	-0.1	0.5
Delay disc. indifference point, 8s delay	0.3	0.4	0.6	0.1	0.8	-0.6	0.7
Indifference point function ln k	0.0	0.1	0.2	0.0	0.5	0.0	0.2
Indifference point function log k	0.0	0.1	0.2	0.0	0.5	0.0	0.2
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	0.4	-0.6	0.3	-0.1
Patch foraging total patch changes 12 sec	0.1	0.1	0.3	0.4	-0.5	-0.0	-0.1
Patch foraging total patch changes 18 sec	0.4	0.7	0.8	0.8	-0.9	0.9	-0.7
Patch foraging total patch changes 24 sec	0.0	0.0	0.1	-0.1	-0.3	-0.1	0.2
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	-0.0	-0.2	-0.2	0.2
Patch foraging time to switch 0 sec	0.1	0.1	0.2	0.3	-0.2	0.3	-0.5
Patch foraging water rate 0 sec	0.0	0.1	0.1	0.3	-0.4	0.1	0.0
Patch foraging water rate 12 sec	0.0	0.1	0.3	-0.0	0.6	-0.0	0.3
Patch foraging water rate 18 sec	0.0	0.1	0.1	-0.2	0.1	0.3	-0.2
Patch foraging water rate 24 sec	0.1	0.1	0.2	-0.4	-0.1	0.4	-0.3
Patch foraging water rate 6 sec	0.3	0.4	1.3	-0.3	1.2	-0.3	0.5
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.1	-0.2	-0.3	-0.2	0.3
Distance traveled before self-admin	0.5	0.7	0.8	-0.9	0.7	-0.8	0.9
Distance traveled after self-admin	2.2	2.7	3.7	1.5	-1.9	1.5	-1.6
Extensor digitorum longus weight	0.2	0.7	1.1	0.0	-0.8	0.9	-1.0
Bone: elastic displacement	0.9	1.1	1.3	-1.1	0.8	-1.0	1.1
Bone: elastic work	9.8	12.8	17.7	-4.2	2.8	-3.6	3.6
Bone: endosteal estimation	0.9	2.0	3.4	0.1	-1.7	1.4	-1.8
Bone: endosteal perimeter	0.3	0.6	1.4	-1.2	-1.0	-0.1	-0.2
Epididymis fat weight	0.1	0.4	0.8	-0.4	-0.9	0.4	-0.7
Delta time in closed arm before/after self-admin	1.5	1.4	1.9	1.4	-1.0	1.2	-1.1
Delta time in open arm before/after self-admin	0.1	0.1	0.3	0.5	-0.1	0.1	0.0
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	-0.2	-0.5	-0.1	-0.3
Delay discount exponential model param	0.3	0.3	0.9	-1.0	-0.5	-0.3	0.1
Extinction: sum of active levers before priming	1.7	1.9	2.9	-1.1	1.7	-1.3	1.3
Active lever presses in extinction session 6	5.8	5.8	8.7	-2.2	2.9	-2.3	2.1
Bone: final force	5.9	9.4	19.3	-4.4	2.6	-2.5	2.3
Bone: final moment	7.0	11.3	22.9	-4.8	2.7	-2.8	2.6
Food consumed during 24 hour testing period	0.2	0.3	0.8	0.4	-0.9	0.3	-0.3
Glucose	7.3	11.5	19.9	-2.1	4.5	-3.3	3.3
Heart weight	2.4	3.8	5.8	-2.4	1.9	-1.8	1.6
Delay discount hyperbolic model param	0.2	0.3	0.8	-0.9	-0.6	-0.2	0.0
Intermittent access intake day 1-15 change	0.2	0.5	1.2	0.8	-1.1	0.2	-0.3
Intermittent access intake escalation	0.2	0.5	1.1	0.8	-1.1	0.2	-0.1
Intermittent access intake escalation 2	0.2	0.2	0.4	-0.2	-0.3	-0.6	0.5
Intermitt. access day 1 inactive lever presses	0.4	1.4	1.9	0.9	-1.4	1.1	-1.2
Intermitt. access day 15 inactive lever presses	0.5	0.9	1.2	0.6	-1.1	1.1	-1.0
Intermitt. access escalation Index	1.1	1.6	2.3	1.4	-1.5	1.1	-0.9
Intermittent access day 1 total infusions	0.1	0.2	0.6	-0.3	0.8	-0.1	-0.0
Intermittent access day 15 total infusions	0.1	0.1	0.2	0.4	-0.4	0.2	-0.2
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.4	-0.5	0.2	-0.3
Intermittent access total infusions	0.1	0.1	0.2	0.5	-0.2	0.3	-0.3
Intermittent access day 1 locomotion	0.1	0.2	0.4	0.5	0.6	0.3	-0.2
Intermittent access day 15 total locomotion	0.0	0.0	0.0	-0.2	0.2	-0.1	0.1
Intermittent access total locomotion	0.0	0.0	0.1	0.3	0.2	0.1	-0.1
Intermittent access standard deviation	0.4	0.8	1.2	-0.3	1.1	-1.0	0.9
Left kidney weight	0.9	4.4	7.8	-2.8	2.1	-1.8	1.5
Right kidney weight	1.0	4.7	6.8	-2.6	2.4	-1.8	1.7
Cocaine induced anxiety	5.6	7.9	8.8	-2.5	3.0	-2.9	2.9
Post-drug Anxiety	5.4	5.8	7.5	-1.8	2.7	-2.5	2.5
Baseline Anxiety	0.6	0.7	1.0	1.0	-0.7	0.8	-0.8
Tail length	0.3	1.0	3.1	-0.5	-1.8	0.4	-0.8
Length with tail	0.7	2.9	5.6	-2.4	1.1	-1.7	1.3
Length without tail	3.6	11.7	13.7	-3.6	3.7	-3.3	3.1
Times rat made contact with spout	0.3	0.3	1.1	0.1	-1.0	-0.3	0.2
Lifetime Intake	0.1	0.2	0.5	0.7	-0.1	0.3	-0.3
Liver weight, left	0.2	0.4	1.4	-0.0	1.2	-0.2	-0.0
Liver weight, right	0.2	0.4	0.7	-0.8	-0.6	0.3	-0.6
Locomotor activity	0.1	0.1	0.2	0.4	0.2	0.3	-0.5
Locomotor testing distance	0.3	0.5	0.8	0.7	-0.2	0.8	-0.9
Locomotor testing rearing	1.2	2.4	3.5	1.9	-1.3	1.5	-1.4
Locomotion in novel chamber	0.0	0.0	0.0	-0.2	-0.2	0.2	-0.2
Locomotion in novel chamber post-restriction	0.5	0.8	3.0	-0.5	-1.7	0.0	-0.3
Fecal boli incidents, locomotor time 1	0.4	0.5	1.0	0.4	-0.5	0.8	-1.0
Change in fecal boli incidents, locomotor task	0.5	0.5	0.8	0.4	0.6	-0.9	0.8
Time >=10cm from walls, locomotor time 1	1.9	2.0	3.9	1.1	-2.0	1.4	-1.1
Bouts of movement, locomotor time 1	0.3	0.3	0.9	-0.1	1.0	-0.3	0.4
Total resting periods, locomotor time 1	0.3	0.3	1.0	0.0	1.0	-0.4	0.4
Rest time, locomotor task time 1	0.1	0.1	0.3	-0.2	0.6	-0.4	0.2
Distance moved, locomotor task time 1	0.2	0.3	0.7	0.8	-0.4	0.4	-0.3
Vertical activity count, locomotor time 1	0.1	0.3	0.4	0.4	-0.6	0.6	-0.5
Time >=10cm from walls, locomotor time 2	0.4	0.6	0.8	-0.9	0.8	-0.6	0.8
Bouts of movement, locomotor time 2	0.1	0.2	0.4	0.6	0.3	0.3	-0.4
Total resting periods, locomotor time 2	0.3	0.5	0.7	0.7	-0.2	0.7	-0.8
Rest time, locomotor task time 2	0.6	0.8	1.6	0.4	-1.3	0.6	-1.0
Distance moved, locomotor task time 2	0.5	0.6	1.8	0.0	1.3	-0.4	0.7
Vertical activity count, locomotor time 2	0.2	0.3	1.0	-0.3	1.0	0.1	-0.0
Light reinforcement 1	0.6	1.4	3.0	0.8	-1.7	1.0	-1.0
Light reinforcement 2	0.2	0.3	0.8	-0.3	-0.9	0.2	-0.3
Bone: marrow area	0.9	1.9	3.2	0.1	-1.6	1.3	-1.8
Bone: maximum diameter	1.8	3.4	8.5	-2.9	1.2	-1.4	1.3
Bone: maximum force	5.2	9.2	20.8	-4.6	2.4	-2.4	2.1
Bone: maximum moment	6.3	11.1	24.3	-4.9	2.5	-2.7	2.5
Mean time between licks in bursts	0.2	0.5	1.4	1.2	0.2	0.5	-0.4
Mean num. licks in bursts	0.2	0.3	0.5	-0.6	0.0	-0.7	0.6
Cd content in liver	1.7	1.9	2.4	1.4	-1.1	1.5	-1.6
Co content in liver	0.1	0.2	0.4	0.2	-0.7	0.3	-0.3
Cu content in liver	0.4	0.4	0.8	-0.5	0.1	-0.8	0.9
Fe content in liver	0.7	0.9	1.4	0.8	-0.6	1.0	-1.2
K content in liver	4.0	3.8	5.1	2.0	-2.3	1.9	-1.7
Mg content in liver	7.1	7.3	8.4	2.9	-2.7	2.7	-2.5
Mn content in liver	0.1	0.1	0.2	0.4	0.5	0.0	0.2
Na content in liver	1.2	1.3	1.9	1.4	-1.0	1.1	-1.0
Rb content in liver	0.5	0.6	1.2	0.3	-1.1	0.9	-0.7
Se content in liver	0.8	1.0	1.5	1.2	-1.1	0.8	-0.7
Sr content in liver	1.6	1.4	2.0	-0.7	1.2	-1.3	1.4
Zn content in liver	1.0	1.1	2.6	0.4	-1.6	0.8	-1.0
Bone: minimum diameter	1.7	3.1	7.8	-2.8	0.6	-1.5	1.4
Time in familiar zone, hab. session 1	0.6	0.6	0.8	-0.5	0.9	-0.8	0.8
Time in novel zone, hab. session 1	0.3	0.3	0.4	0.7	-0.5	0.5	-0.3
Total zone transitions, hab. session 1	0.1	0.2	0.6	0.2	0.8	0.1	-0.0
Total locomotion distance, hab. session 1	0.1	0.1	0.1	-0.2	0.4	0.3	-0.3
Locomotion velocity, hab. session 1	0.1	0.1	0.2	-0.2	0.2	0.4	-0.5
Time in familiar zone, hab. session 2	0.2	0.3	0.5	0.7	-0.3	0.4	-0.5
Time in novel zone, hab. session 2	0.2	0.2	0.4	-0.4	0.6	-0.3	0.4
Total zone transitions, hab. session 2	0.8	1.0	1.6	0.8	-0.7	1.3	-1.2
Total locomotion distance, hab. session 2	0.9	1.2	1.8	0.6	-1.0	1.3	-1.3
Locomotion velocity, hab. session 2	0.7	1.0	1.4	0.4	-1.0	1.2	-1.2
Novel to familiar place preference ratio	2.8	3.0	4.0	-2.0	1.2	-1.9	1.8
Novelty place preference	3.1	3.4	4.4	-2.1	1.2	-1.9	1.9
Time in novel zone, NPP test	2.4	2.6	3.4	-1.8	1.1	-1.7	1.7
Total zone transitions, NPP test	2.1	3.0	4.2	1.5	-1.3	2.1	-2.0
Total locomotion distance, NPP test	2.4	3.3	4.6	1.4	-1.4	2.1	-2.1
Locomotion velocity, NPP test	1.5	2.1	3.0	1.0	-1.2	1.7	-1.7
Intraocular pressure	0.5	0.7	1.4	-0.3	-1.2	0.7	-0.9
Delta distance traveled before/after self-admin	2.7	2.9	3.6	1.9	-1.8	1.5	-1.6
Delta ambulatory time before/after self-admin	3.9	4.8	6.2	2.5	-2.2	2.0	-2.0
Parametrial fat weight	0.3	0.6	0.9	0.6	-0.9	0.7	-1.0
Pavlov. Cond. lever latency	1.6	2.0	2.9	1.2	-1.1	1.7	-1.6
Pavlov. Cond. magazine entry latency	2.0	2.6	3.5	-1.6	1.1	-1.9	1.8
Pavlov. Cond. change in total contacts	1.9	2.0	2.4	-1.0	1.5	-1.6	1.5
Pavlov. Cond. index score	1.5	1.9	2.5	-1.5	0.7	-1.6	1.5
Pavlov. Cond. latency score	1.6	2.0	2.8	-1.5	0.7	-1.7	1.6
Pavlov. Cond. lever contacts	0.4	0.5	0.8	-0.7	0.5	-0.9	0.8
Pavlov. Cond. magazine entry number	3.4	4.3	5.6	2.0	-1.6	2.4	-2.3
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.1	0.6	-1.1	1.0	-1.1
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.0	2.6	-1.5	0.8	-1.6	1.6
Pavlov. Cond. response bias	2.6	3.2	4.2	-1.7	1.4	-2.0	1.9
Pavlov. Cond. lever latency	0.7	1.0	1.8	-0.2	1.3	-1.0	1.1
Pavlov. Cond. magazine entry latency	2.4	2.9	3.9	1.9	-0.8	1.9	-2.0
Pavlov. Cond. change in total contacts	0.4	0.7	1.0	0.4	-0.8	1.0	-1.0
Pavlov. Cond. index score	0.8	1.1	1.9	0.8	-0.7	1.2	-1.4
Pavlov. Cond. latency score	1.1	1.5	2.3	0.9	-0.9	1.4	-1.5
Pavlov. Cond. lever contacts	0.8	1.1	1.9	0.3	-1.4	1.1	-1.2
Pavlov. Cond. magazine entry number	2.0	2.5	3.4	-1.9	0.8	-1.7	1.8
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.7	-0.8	-0.1	-0.2	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.3	2.0	1.0	-0.7	1.3	-1.4
Pavlov. Cond. response bias	0.6	0.9	1.3	0.6	-0.9	1.0	-1.2
Time in closed arm before self-admin	1.2	1.5	2.1	-1.0	1.5	-1.2	1.3
Time in closed arm after self-admin	0.2	0.2	0.3	0.4	0.6	-0.4	0.4
Time in open arm before self-admin	0.4	0.5	0.8	0.1	-0.9	0.7	-0.7
Time in open arm after self-admin	0.1	0.1	0.1	-0.0	-0.1	0.4	-0.3
Bone: periosteal estimation	1.4	3.0	9.6	-3.1	0.8	-1.1	0.8
Bone: periosteal perimeter	5.3	9.1	17.5	-4.2	2.0	-2.9	2.6
Bone: post-yield work	0.1	0.1	0.3	-0.5	0.1	0.0	-0.1
Progressive ratio test 1 active lever presses	0.3	0.3	0.7	0.8	-0.5	0.5	-0.5
Progressive ratio test 1 breakpoint	0.3	0.3	0.6	0.8	-0.5	0.4	-0.5
Progressive ratio test 1 inactive lever presses	0.8	1.1	1.7	0.8	-1.3	1.0	-1.0
Progressive ratio test 2 active lever presses	0.2	0.3	0.4	0.4	-0.5	0.5	-0.6
Progressive ratio test 2 breakpoint	0.2	0.2	0.4	0.4	-0.4	0.5	-0.6
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.1	-0.3	0.4	-0.4	0.2
Incentive Sensitization - Responses	0.2	0.3	0.5	0.3	-0.6	0.6	-0.7
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	0.2	-0.5	0.5	-0.6
Sum of active levers in priming session hrs 5-6	1.3	1.2	1.6	-0.9	1.3	-1.2	0.9
Progressive ratio	0.2	0.3	0.5	-0.7	0.7	-0.0	-0.2
Food seeking constrained by brief footshock	0.2	0.2	0.3	0.0	0.3	-0.5	0.6
Seeking ratio, punishment vs. effort	0.1	0.2	0.4	0.7	-0.5	0.2	0.1
Retroperitoneal fat weight	0.4	1.7	3.6	-0.6	-1.9	1.0	-1.4
Reaction time number correct	2.5	4.8	6.3	1.9	-2.1	2.5	-2.3
Reaction time mean minus median	0.0	0.0	0.1	0.0	-0.2	-0.3	0.1
Reaction time mean minus median AUC	0.0	0.0	0.1	-0.1	-0.2	-0.1	0.0
Reaction time num false alarms	0.0	0.0	0.2	-0.4	-0.1	-0.1	-0.1
Reaction time num false alarms AUC	0.1	0.1	0.2	0.0	-0.3	0.3	-0.4
Reaction time trials correct on left	2.5	4.8	6.3	1.9	-2.1	2.5	-2.3
Reaction time trials on left	2.7	5.0	6.6	1.9	-2.1	2.6	-2.3
Reaction time mean	0.1	0.1	0.2	-0.4	-0.4	-0.1	-0.1
Reaction time mean AUC	0.1	0.2	0.5	-0.1	-0.7	0.4	-0.5
Median of all reaction times	0.0	0.1	0.2	-0.4	-0.3	0.0	-0.1
Reaction time omissions	0.3	0.5	1.0	0.5	-1.0	0.6	-0.6
Reaction time false alarm rate	0.5	0.7	1.0	-0.9	0.7	-1.0	0.8
Reaction time premature initiation rate	0.2	0.2	0.7	0.9	-0.1	0.3	-0.3
Reaction time premature initiations	1.5	2.7	3.1	1.8	-1.3	1.7	-1.7
Std. dev. reaction times	0.1	0.2	0.4	0.3	-0.6	0.3	-0.5
Reaction time trials completed	2.7	5.0	6.6	1.9	-2.1	2.6	-2.3
Reaction time trials AUC	2.5	4.7	6.2	1.8	-2.1	2.5	-2.2
Run reversals in cocaine runway, females	0.5	0.5	0.7	0.6	-0.4	0.8	-0.8
Run reversals in cocaine runway, males	0.5	0.5	0.8	-0.9	0.1	-0.9	0.7
Latency to leave start box in cocaine runway	0.7	0.8	1.5	0.7	-0.5	1.0	-1.2
Latency to leave start box in cocaine runway, F	2.2	2.5	3.9	1.1	-1.2	1.8	-2.0
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.1	0.5	-0.5	0.3
Std. dev. time between licks in bursts	2.3	3.1	4.1	1.5	-1.6	2.0	-1.8
Total sessions with >9 infusions	0.1	0.1	0.2	0.4	0.1	0.2	-0.2
Short access day 1 total inactive lever presses	0.2	0.3	0.5	0.3	0.3	0.6	-0.7
Short access day 10 total inactive lever presses	0.1	0.2	0.4	-0.1	-0.6	0.4	-0.4
Short access day 1 total infusions	0.2	0.2	0.5	0.7	0.7	0.1	0.1
Short access day 10 total infusions	0.1	0.2	0.3	0.4	-0.5	0.1	-0.3
Short access total infusions	0.2	0.2	0.7	0.9	0.0	0.2	-0.1
Short access day 1 locomotion	0.7	0.9	1.7	-0.4	1.3	-0.9	1.0
Short access day 10 total locomotion	0.5	1.0	1.8	-0.2	1.3	-1.0	1.0
Short access total locomotion	0.7	0.8	1.3	-0.2	1.1	-1.0	1.0
One hour access (0.3 mA shock)	0.3	0.3	0.5	0.6	-0.3	0.6	-0.7
Compulsive drug intake	0.6	0.7	0.9	0.6	-0.8	0.9	-0.9
One hour access (shock baseline)	0.2	0.3	0.4	0.6	-0.5	0.5	-0.6
Social response proportion	0.1	0.1	0.1	0.4	-0.2	0.4	-0.3
Social responses	0.0	0.0	0.1	0.4	-0.1	0.2	0.0
Social time	0.2	0.2	0.5	-0.5	0.7	-0.2	0.3
Soleus weight	0.1	0.2	0.5	-0.5	-0.7	-0.3	0.3
Bone: stiffness	2.1	3.3	6.7	-2.6	2.1	-1.2	1.0
Tibialis anterior weight	0.1	0.3	0.5	0.3	-0.7	0.5	-0.6
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.5	-0.2	0.4	-0.2
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.5	0.3	0.7	0.2	-0.2
Time to tail flick, test, before self-admin	0.7	0.7	1.8	1.4	-0.5	0.7	-0.6
Time to tail flick, test, after self-admin	0.3	0.3	0.8	0.9	0.6	-0.1	0.2
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.7	0.6	-0.4	0.6	-0.8
Delta time to tail flick, test, before/after SA	2.0	2.1	2.8	-1.3	1.7	-1.4	1.3
Tibia length	8.8	24.2	47.7	-6.9	3.2	-4.5	4.3
Ambulatory time before self-admin	0.9	1.3	1.6	-1.3	0.8	-1.1	1.2
Ambulatory time after self-admin	0.6	0.7	1.3	0.7	-1.1	0.7	-0.8
Bone: tissue strength	0.7	0.7	2.6	-1.6	0.4	-0.3	0.2
Total heroin consumption	3.2	3.7	5.1	-2.3	2.1	-1.7	1.5
Bone: trabecular number	0.0	0.0	0.1	0.2	-0.2	-0.0	0.1
Bone: trabecular spacing	2.2	2.9	4.1	1.1	-1.5	2.0	-2.0
Bone: trabecular thickness	2.2	2.8	3.7	-1.7	1.0	-1.9	1.9
Bone: trabecular tissue density	0.1	0.2	0.3	0.5	0.2	0.5	-0.5
Water consumed over 24 hours	0.2	0.3	0.5	-0.2	0.1	-0.7	0.7
Number of responses in last shaping day	0.3	0.3	1.1	0.2	1.0	-0.3	0.4