Hub : Genes

RT1-S2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression RT1-S2 0.42 0.06 0.0e+00 0.68 0.67 0.7 0.68 2.8e-102 8.9e-100 5.2e-107 4.6e-103
2 LHb intron excision ratio chr20_2626206_2626386 0.3 0.16 3.8e-05 0.07 0.14 0.11 0.15 9.0e-03 4.4e-04 1.2e-03 2.1e-04
3 IL gene expression RT1-S2 0.46 0.06 0.0e+00 0.4 0.46 0.46 0.5 1.1e-10 1.3e-12 2.3e-12 8.7e-14
4 LHb intron excision ratio chr20_2672840_2673017 0.35 0.17 6.1e-06 0.11 0.16 0.12 0.17 1.6e-03 1.1e-04 7.9e-04 9.0e-05
5 Eye gene expression RT1-S2 0.48 0.21 2.1e-04 0.04 0.14 0.1 0.07 9.0e-02 3.9e-03 1.1e-02 3.1e-02
6 LHb gene expression RT1-S2 0.76 0.15 0.0e+00 0.43 0.53 0.52 0.54 1.8e-11 5.7e-15 1.8e-14 5.6e-15
7 NAcc gene expression RT1-S2 0.56 0.07 0.0e+00 0.65 0.69 0.7 0.69 2.0e-99 4.7e-112 2.8e-112 1.1e-111
8 BLA gene expression RT1-S2 0.63 0.09 0.0e+00 0.54 0.58 0.58 0.6 3.7e-34 8.1e-38 4.2e-37 2.8e-39
9 Brain gene expression RT1-S2 0.44 0.06 0.0e+00 0.56 0.66 0.65 0.64 5.7e-62 2.4e-80 3.2e-79 4.6e-78
10 OFC gene expression RT1-S2 0.76 0.13 0.0e+00 0.31 0.38 0.38 0.38 4.9e-08 5.1e-10 6.2e-10 7.5e-10
11 LHb intron excision ratio chr20_2651275_2651455 0.23 0.14 5.4e-04 0.04 0.12 0.07 0.09 4.5e-02 1.1e-03 9.0e-03 4.5e-03
12 Adipose gene expression RT1-S2 0.59 0.17 0.0e+00 0.38 0.42 0.42 0.43 1.0e-44 1.1e-49 5.4e-51 8.2e-52
13 pVTA gene expression RT1-S2 0.51 0.11 0.0e+00 0.38 0.37 0.46 0.41 9.0e-18 3.7e-17 2.7e-22 2.3e-19

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.22.12.91.61.7-1.7-1.7-0.6-1.71.4-1.7-1.4-1.41.4-0.81.2
Area under the delay curve2.42.63.0-1.6-1.61.61.61.61.6-1.61.61.61.7-1.71.7-1.4
BMI with tail2.27.17.8-2.7-2.82.82.62.62.6-2.82.62.72.7-2.72.5-2.6
BMI without tail4.08.39.6-3.1-3.03.03.02.33.0-3.03.03.02.9-2.92.5-2.7
Body weight7.029.534.0-5.8-5.85.85.84.05.7-5.55.75.55.4-5.44.6-5.1
Weight adjusted by age3.13.55.0-2.0-1.91.91.71.31.6-2.02.22.12.0-2.01.7-1.9
Bone surface0.10.20.2-0.5-0.50.50.50.00.5-0.40.50.40.4-0.30.2-0.2
Bone volume0.10.10.2-0.3-0.30.30.30.50.3-0.40.30.30.4-0.40.5-0.3
Breakpoint value in progressive ratio session1.31.41.81.21.2-1.2-1.3-1.0-1.31.3-1.2-1.2-1.11.2-1.11.3
Number of licking bursts0.40.41.20.50.4-0.4-0.4-1.1-0.40.7-0.4-0.6-0.70.7-0.90.8
Context. condit. distance diff. score7.38.812.62.82.6-2.6-2.6-3.6-2.73.1-2.5-3.0-3.13.1-3.53.2
Locomotion velocity, session 10.20.30.60.40.4-0.4-0.4-0.8-0.40.5-0.3-0.5-0.50.5-0.70.6
Locomotion distance, session 10.30.30.70.70.8-0.8-0.80.2-0.70.5-0.8-0.5-0.40.40.10.2
Locomotion velocity, session 20.00.00.10.00.0-0.00.0-0.30.00.10.0-0.1-0.10.1-0.30.2
Locomotion distance, session 20.30.40.60.70.8-0.8-0.7-0.4-0.70.7-0.7-0.6-0.60.6-0.40.6
Locomotion velocity, session 30.10.10.5-0.1-0.10.10.10.70.1-0.30.10.30.3-0.30.6-0.4
Locomotion distance, session 31.61.82.11.51.4-1.4-1.4-1.0-1.41.4-1.5-1.4-1.31.3-1.11.3
Stereotopy head waving bouts, day 31.51.72.6-1.5-1.51.51.60.41.6-1.31.61.31.2-1.20.7-1.0
Stereotopy head waving duration, day 31.11.31.9-1.3-1.31.31.30.51.3-1.21.41.21.1-1.10.7-0.9
Locomotion velocity, session 75.05.45.92.42.4-2.4-2.4-2.0-2.42.4-2.4-2.4-2.42.4-2.22.2
Locomotion distance, session 74.45.66.52.52.5-2.5-2.5-1.7-2.52.4-2.5-2.4-2.32.3-2.02.2
Stereotopy head waving bouts, day 72.32.62.9-1.7-1.71.71.71.31.7-1.61.71.61.6-1.61.4-1.5
Stereotopy head waving duration, day 73.03.64.2-2.0-2.12.02.01.42.0-1.92.01.91.9-1.91.6-1.8
Locomotion velocity, session 80.50.63.20.1-0.0-0.00.1-1.80.00.60.2-0.5-0.60.6-1.41.0
Locomotion distance, session 83.95.87.82.32.1-2.2-2.1-2.8-2.22.5-2.1-2.4-2.52.5-2.72.6
Degree of sensitization distance0.50.50.90.60.6-0.6-0.5-1.0-0.50.7-0.5-0.7-0.70.7-1.00.8
Degree of sensitization stereotypy1.51.61.9-1.3-1.41.41.31.11.3-1.31.31.31.3-1.31.2-1.3
Conditioned locomotion0.60.71.0-0.9-1.01.01.00.41.0-0.81.00.80.8-0.80.6-0.6
Cocaine response after cond. corrected0.50.50.70.80.8-0.8-0.8-0.5-0.80.7-0.8-0.8-0.70.7-0.50.7
Cocaine response after cond. not corrected0.10.10.2-0.4-0.40.40.4-0.30.4-0.20.40.20.2-0.2-0.0-0.0
Cocaine response before conditioning4.55.57.5-2.7-2.72.72.71.12.6-2.32.72.32.2-2.21.4-1.9
Saline control response1.41.93.4-1.3-1.11.11.11.81.1-1.41.11.41.4-1.41.8-1.5
Bone: connectivity density2.94.65.22.32.3-2.3-2.2-1.7-2.22.2-2.3-2.2-2.12.1-1.82.1
Bone: cortical apparent density0.71.02.7-0.7-0.50.60.61.70.6-1.00.50.91.0-1.01.5-1.3
Bone: cortical area2.63.94.3-2.1-2.02.02.01.62.0-2.02.02.02.0-2.01.8-1.9
Bone: cortical porosity0.70.71.0-0.8-0.70.70.71.00.7-0.90.70.90.9-0.91.0-1.0
Bone: cortical porosity0.70.70.9-1.0-0.90.90.90.50.9-0.90.90.90.8-0.80.6-0.8
Bone: cortical thickness4.26.911.4-2.4-2.12.22.23.42.2-2.72.12.62.8-2.83.3-2.9
Bone: cortical thickness1.01.23.5-0.7-0.60.60.61.90.7-1.10.61.01.1-1.11.7-1.4
Bone: cortical tissue density0.60.82.2-0.6-0.50.50.51.50.5-0.90.50.80.9-0.91.4-1.2
Condit. Reinf. active minus inactive responses1.01.11.41.11.2-1.2-1.1-0.9-1.01.1-1.0-1.0-1.01.0-1.01.0
Condit. Reinf. active-inactive response ratio0.00.00.20.00.2-0.1-0.00.40.0-0.1-0.00.10.2-0.10.4-0.2
Condit. Reinf. active responses1.41.72.01.41.4-1.4-1.4-1.0-1.41.4-1.4-1.3-1.31.3-1.11.2
Condit. Reinf. inactive responses2.02.33.11.71.6-1.6-1.7-0.9-1.71.5-1.8-1.6-1.51.5-1.11.3
Incentive salience index mean1.92.33.41.41.4-1.4-1.3-1.9-1.31.6-1.3-1.5-1.61.6-1.81.6
Condit. Reinf. lever presses3.24.36.91.91.7-1.7-1.8-2.6-1.82.2-1.7-2.1-2.22.2-2.52.2
Condit. Reinf. active minus inactive responses1.41.72.1-1.4-1.51.41.40.91.4-1.31.51.31.3-1.31.1-1.2
Condit. Reinf. active-inactive response ratio2.82.93.8-1.9-2.01.91.91.01.9-1.72.01.71.6-1.61.2-1.4
Condit. Reinf. active responses0.00.00.0-0.0-0.00.00.0-0.10.00.00.0-0.0-0.00.0-0.00.0
Condit. Reinf. inactive responses1.82.22.51.61.6-1.6-1.6-1.1-1.61.5-1.6-1.5-1.51.5-1.21.4
Condit. Reinf. lever presses0.40.60.70.80.8-0.8-0.8-0.6-0.80.7-0.8-0.8-0.80.8-0.60.7
Condit. Reinf. lever reinforcers received0.00.00.10.20.1-0.1-0.2-0.3-0.20.2-0.1-0.2-0.20.2-0.30.3
Conditioned reinforcement - actives0.40.40.6-0.6-0.30.30.60.70.7-0.60.60.60.7-0.60.8-0.6
Conditioned reinforcement - inactives1.41.62.6-1.2-1.01.11.21.51.3-1.31.11.21.3-1.31.6-1.2
Conditioned locomotion0.00.00.0-0.00.2-0.1-0.1-0.1-0.10.00.20.00.1-0.1-0.20.1
Patch foraging indifference point 0 sec0.60.92.5-0.7-0.40.40.51.60.6-1.00.60.81.0-0.91.5-1.2
Patch foraging indifference point AUC2.73.13.9-1.9-2.02.01.81.31.8-1.81.81.81.7-1.71.4-1.7
Delay disc. indifference point, 0s delay0.40.40.7-0.7-0.60.60.80.30.8-0.60.70.60.6-0.60.4-0.5
Delay disc. indifference point, 16s delay2.02.14.4-1.2-1.21.31.02.10.9-1.51.11.41.5-1.52.0-1.5
Delay disc. indifference point, 2s delay2.22.44.4-1.6-1.51.51.91.02.1-1.51.61.61.5-1.51.3-1.2
Delay disc. indifference point, 24s delay0.70.71.1-0.7-0.80.80.71.00.7-0.90.70.80.8-0.80.9-0.8
Delay disc. indifference point, 4s delay3.03.25.2-1.9-1.91.92.21.12.3-1.81.91.81.8-1.71.4-1.4
Delay disc. indifference point, 8s delay0.40.40.7-0.6-0.60.60.50.70.5-0.70.70.70.7-0.70.8-0.5
Indifference point function ln k0.60.81.30.80.8-0.8-0.8-1.1-0.71.0-0.8-0.9-0.90.9-1.11.1
Indifference point function log k0.60.81.30.80.8-0.8-0.8-1.1-0.71.0-0.8-0.9-0.90.9-1.11.1
Patch foraging total patch changes 0 sec0.81.33.6-0.9-0.60.60.71.90.8-1.20.81.11.2-1.21.8-1.5
Patch foraging total patch changes 12 sec1.21.53.4-1.0-0.90.90.81.80.9-1.30.81.11.2-1.21.7-1.5
Patch foraging total patch changes 18 sec0.40.63.0-0.3-0.10.20.11.70.1-0.70.10.50.7-0.71.4-0.8
Patch foraging total patch changes 24 sec0.40.51.10.81.0-0.9-0.91.1-0.80.2-0.8-0.4-0.20.20.8-0.2
Patch foraging total patch changes 6 sec0.91.34.1-0.9-0.50.60.62.00.6-1.20.51.01.1-1.11.8-1.5
Patch foraging time to switch 0 sec0.20.40.70.70.9-0.8-0.80.3-0.70.5-0.8-0.5-0.40.40.20.1
Patch foraging water rate 0 sec0.50.80.9-1.0-0.90.90.90.90.9-1.00.90.90.9-1.00.7-0.8
Patch foraging water rate 12 sec0.10.10.20.20.4-0.4-0.40.4-0.40.1-0.3-0.1-0.10.10.10.1
Patch foraging water rate 18 sec0.20.30.5-0.6-0.50.50.60.40.6-0.60.70.60.6-0.60.4-0.6
Patch foraging water rate 24 sec1.82.63.0-1.7-1.61.61.61.51.6-1.71.61.71.7-1.71.4-1.4
Patch foraging water rate 6 sec0.00.10.4-0.00.0-0.0-0.00.6-0.0-0.20.00.20.2-0.20.30.1
Seeking ratio, delayed vs. immediate footshock0.50.50.9-0.8-0.70.70.90.60.9-0.70.80.80.8-0.80.6-0.5
Distance traveled before self-admin0.10.10.40.10.00.0-0.1-0.6-0.10.3-0.1-0.2-0.20.2-0.60.5
Distance traveled after self-admin0.20.20.6-0.5-0.80.80.4-0.20.2-0.30.60.40.3-0.3-0.0-0.3
Extensor digitorum longus weight0.00.10.3-0.3-0.30.30.4-0.60.4-0.10.40.10.0-0.0-0.4-0.0
Bone: elastic displacement0.20.20.7-0.3-0.20.20.20.80.3-0.40.20.40.5-0.50.7-0.5
Bone: elastic work2.32.93.2-1.7-1.61.61.61.71.7-1.81.61.71.8-1.81.8-1.7
Bone: endosteal estimation1.53.35.8-2.2-2.42.42.4-0.52.3-1.62.41.71.4-1.40.2-1.0
Bone: endosteal perimeter0.30.63.7-0.3-0.50.50.5-1.90.40.30.5-0.2-0.40.4-1.50.8
Epididymis fat weight3.07.022.0-1.9-1.61.71.54.71.5-2.61.52.52.7-2.74.0-3.1
Delta time in closed arm before/after self-admin0.20.20.3-0.4-0.40.40.50.40.6-0.50.50.40.4-0.40.4-0.5
Delta time in open arm before/after self-admin0.00.00.1-0.2-0.10.20.00.20.0-0.20.00.10.1-0.10.3-0.3
Diff in mean of infusions in LGA sessions3.84.25.32.22.3-2.3-2.2-1.3-2.12.1-2.3-2.1-2.02.0-1.62.0
Delay discount exponential model param2.42.52.81.51.5-1.5-1.6-1.6-1.71.6-1.6-1.6-1.61.6-1.71.3
Extinction: sum of active levers before priming0.60.61.00.80.9-0.9-1.0-0.3-1.00.7-0.9-0.8-0.70.7-0.40.4
Active lever presses in extinction session 60.10.10.70.10.1-0.0-0.70.4-0.90.0-0.1-0.0-0.00.00.1-0.1
Bone: final force7.411.913.0-3.5-3.33.33.33.53.3-3.63.33.53.6-3.63.6-3.5
Bone: final moment6.710.911.7-3.3-3.23.23.23.23.2-3.43.23.43.4-3.43.4-3.3
Food consumed during 24 hour testing period0.60.71.1-1.0-1.11.01.1-0.01.0-0.71.10.80.7-0.70.2-0.5
Glucose1.42.28.40.80.5-0.6-0.6-2.9-0.71.4-0.6-1.3-1.51.5-2.51.6
Heart weight0.10.10.3-0.4-0.40.40.40.20.4-0.40.50.40.4-0.40.2-0.3
Delay discount hyperbolic model param2.42.53.21.61.6-1.6-1.7-1.5-1.81.6-1.6-1.6-1.61.6-1.61.3
Intermittent access intake day 1-15 change0.80.81.1-1.0-1.00.91.00.81.1-0.90.90.90.9-0.90.7-0.5
Intermittent access intake escalation0.30.30.5-0.6-0.70.60.70.10.7-0.50.60.40.5-0.50.1-0.1
Intermittent access intake escalation 20.20.21.3-0.2-0.40.40.2-1.20.00.20.2-0.2-0.20.2-1.00.6
Intermitt. access day 1 inactive lever presses0.10.10.3-0.4-0.50.50.2-0.20.1-0.30.40.20.2-0.2-0.1-0.0
Intermitt. access day 15 inactive lever presses2.62.93.8-1.9-1.91.91.31.51.1-1.91.81.81.7-1.81.7-1.7
Intermitt. access escalation Index3.63.24.02.01.9-1.9-1.7-1.6-1.61.8-1.9-1.9-1.81.9-1.71.6
Intermittent access day 1 total infusions0.50.61.20.81.1-1.1-0.8-0.3-0.60.8-0.9-0.8-0.60.7-0.20.6
Intermittent access day 15 total infusions0.10.10.30.30.5-0.5-0.10.00.00.3-0.3-0.2-0.10.20.00.4
Intermittent access terminal intake (last 3 days)0.10.10.2-0.2-0.00.00.20.40.2-0.20.10.20.3-0.30.4-0.1
Intermittent access total infusions0.00.00.10.20.4-0.4-0.10.2-0.00.1-0.1-0.10.00.00.20.2
Intermittent access day 1 locomotion0.30.30.60.60.8-0.7-0.2-0.70.00.6-0.5-0.6-0.50.6-0.40.5
Intermittent access day 15 total locomotion0.60.61.2-0.9-0.80.80.90.20.9-0.71.10.90.8-0.80.4-0.4
Intermittent access total locomotion0.30.40.7-0.7-0.70.60.80.10.8-0.60.80.60.6-0.60.3-0.3
Intermittent access standard deviation3.03.23.7-1.9-1.81.81.61.91.5-1.91.81.81.9-1.91.7-1.6
Left kidney weight4.412.413.9-3.7-3.63.63.62.83.7-3.63.73.63.6-3.53.2-3.4
Right kidney weight3.59.911.9-3.4-3.43.43.52.03.4-3.23.43.23.1-3.12.3-3.0
Cocaine induced anxiety3.13.65.31.81.7-1.7-1.7-2.3-1.81.9-1.7-1.9-2.02.0-2.21.8
Post-drug Anxiety1.21.32.11.00.9-0.9-1.2-1.4-1.41.1-1.0-1.1-1.21.2-1.41.0
Baseline Anxiety0.10.10.6-0.3-0.30.30.10.80.0-0.40.10.30.3-0.30.6-0.5
Tail length4.112.417.7-4.1-4.24.14.21.24.1-3.44.23.53.3-3.31.9-2.7
Length with tail4.215.420.4-4.4-4.54.54.51.94.4-3.94.54.03.8-3.82.6-3.3
Length without tail3.47.39.3-2.9-3.03.03.01.62.9-2.73.02.72.6-2.62.2-2.5
Times rat made contact with spout1.01.11.91.21.4-1.3-1.30.0-1.31.0-1.4-1.0-0.90.9-0.20.7
Lifetime Intake0.00.00.10.10.4-0.4-0.10.2-0.00.1-0.1-0.00.0-0.00.20.1
Liver weight, left0.30.50.9-0.9-0.90.90.9-0.30.9-0.60.90.60.5-0.50.2-0.7
Liver weight, right2.64.36.7-2.4-2.62.52.60.22.5-1.92.52.01.8-1.80.8-1.5
Locomotor activity0.71.12.1-1.2-1.41.31.5-0.51.4-0.91.40.90.8-0.8-0.1-0.6
Locomotor testing distance0.10.10.2-0.4-0.40.40.5-0.40.5-0.20.40.20.2-0.2-0.2-0.2
Locomotor testing rearing0.30.50.9-0.8-0.90.90.9-0.20.9-0.60.80.60.6-0.50.1-0.5
Locomotion in novel chamber0.91.12.0-0.9-0.91.01.30.81.4-1.01.11.01.0-1.01.0-0.9
Locomotion in novel chamber post-restriction0.81.01.1-1.0-1.01.01.01.01.0-0.91.01.01.0-1.01.0-0.9
Fecal boli incidents, locomotor time 11.01.11.81.11.0-1.0-1.3-0.8-1.31.1-1.2-1.0-1.01.0-0.90.9
Change in fecal boli incidents, locomotor task0.70.61.0-0.9-0.90.90.90.50.9-0.81.00.80.8-0.80.5-0.6
Time >=10cm from walls, locomotor time 10.30.30.7-0.8-0.80.80.5-0.30.3-0.50.60.50.4-0.40.0-0.2
Bouts of movement, locomotor time 11.41.52.21.21.0-1.0-1.1-1.5-1.21.3-1.1-1.2-1.31.3-1.41.2
Total resting periods, locomotor time 10.60.71.50.80.6-0.6-0.7-1.2-0.80.9-0.7-0.8-0.90.9-1.10.8
Rest time, locomotor task time 10.10.10.8-0.1-0.30.20.1-0.9-0.00.20.1-0.1-0.20.2-0.70.2
Distance moved, locomotor task time 10.70.81.4-0.8-0.70.70.71.20.7-1.00.80.90.9-0.91.0-1.0
Vertical activity count, locomotor time 10.30.40.8-0.5-0.40.40.50.90.5-0.70.50.50.6-0.70.7-0.7
Time >=10cm from walls, locomotor time 20.00.00.20.0-0.10.10.2-0.50.20.00.0-0.1-0.10.1-0.40.1
Bouts of movement, locomotor time 20.50.62.2-0.7-0.80.71.3-0.41.5-0.40.80.50.5-0.5-0.1-0.1
Total resting periods, locomotor time 20.30.41.4-0.4-0.60.51.0-0.81.2-0.10.70.20.2-0.1-0.50.2
Rest time, locomotor task time 20.60.73.60.3-0.0-0.0-0.1-1.9-0.20.8-0.2-0.7-0.80.8-1.61.0
Distance moved, locomotor task time 20.80.92.7-0.7-0.50.60.61.60.7-1.00.60.91.0-1.01.4-1.2
Vertical activity count, locomotor time 20.10.10.6-0.1-0.00.10.10.80.1-0.30.10.20.3-0.30.5-0.4
Light reinforcement 10.10.20.9-0.3-0.20.20.30.90.3-0.50.40.50.5-0.50.5-0.4
Light reinforcement 20.60.91.4-1.0-1.11.11.10.41.0-0.91.20.90.9-0.90.4-0.7
Bone: marrow area1.53.35.8-2.2-2.42.32.4-0.42.3-1.62.41.71.4-1.40.2-1.0
Bone: maximum diameter0.30.61.2-0.9-1.11.11.1-0.71.0-0.61.10.60.5-0.5-0.3-0.3
Bone: maximum force6.110.511.3-3.3-3.23.23.23.13.2-3.43.23.33.3-3.33.3-3.3
Bone: maximum moment5.69.610.3-3.2-3.13.13.12.83.1-3.23.13.23.2-3.23.0-3.1
Mean time between licks in bursts0.40.63.20.20.0-0.1-0.1-1.8-0.10.7-0.1-0.6-0.70.7-1.50.9
Mean num. licks in bursts0.10.21.10.20.3-0.3-0.31.0-0.2-0.2-0.30.10.2-0.20.7-0.3
Cd content in liver0.70.71.5-0.7-0.80.80.71.20.6-0.90.60.80.9-0.91.1-0.9
Co content in liver1.82.03.6-1.3-1.21.21.11.91.2-1.51.11.41.5-1.51.9-1.6
Cu content in liver2.93.55.12.12.2-2.2-2.2-0.6-2.21.8-2.2-1.8-1.71.7-1.01.5
Fe content in liver0.50.61.4-0.7-0.60.70.61.20.6-0.90.60.80.8-0.91.0-0.8
K content in liver0.10.10.20.40.3-0.4-0.4-0.3-0.40.4-0.4-0.4-0.40.4-0.30.3
Mg content in liver2.92.94.81.61.4-1.5-1.5-2.2-1.51.8-1.5-1.7-1.81.8-2.11.7
Mn content in liver2.02.26.61.10.9-1.0-0.8-2.6-0.91.5-0.8-1.4-1.51.5-2.31.7
Na content in liver0.10.10.3-0.2-0.10.10.20.50.2-0.30.20.30.3-0.30.5-0.4
Rb content in liver1.01.31.51.21.0-1.0-1.1-0.9-1.21.1-1.2-1.2-1.21.2-1.11.1
Se content in liver1.41.75.11.00.7-0.7-0.7-2.3-0.81.3-0.8-1.2-1.31.4-2.01.5
Sr content in liver0.40.40.7-0.7-0.60.60.80.10.8-0.60.80.60.6-0.60.4-0.5
Zn content in liver0.00.00.10.10.3-0.2-0.1-0.3-0.00.1-0.1-0.1-0.10.1-0.20.1
Bone: minimum diameter0.40.81.5-1.0-1.21.21.2-0.81.1-0.61.20.70.5-0.5-0.3-0.2
Time in familiar zone, hab. session 12.82.64.01.92.0-2.0-2.0-0.4-1.91.6-2.0-1.6-1.51.4-0.71.2
Time in novel zone, hab. session 11.31.22.0-1.3-1.41.41.40.01.3-1.01.41.00.9-0.90.3-0.7
Total zone transitions, hab. session 10.60.91.11.01.0-1.0-1.0-0.7-1.01.0-1.0-1.0-0.90.9-0.70.8
Total locomotion distance, hab. session 10.50.71.01.01.0-1.0-0.9-0.5-0.90.9-1.0-0.9-0.80.8-0.60.7
Locomotion velocity, hab. session 10.20.30.50.60.7-0.7-0.6-0.0-0.60.5-0.6-0.5-0.40.4-0.20.3
Time in familiar zone, hab. session 20.20.20.40.50.7-0.6-0.6-0.0-0.60.4-0.6-0.4-0.40.4-0.10.2
Time in novel zone, hab. session 20.30.30.5-0.6-0.70.70.70.40.6-0.60.60.60.6-0.60.4-0.5
Total zone transitions, hab. session 20.00.00.20.10.1-0.1-0.10.4-0.1-0.0-0.10.10.1-0.10.4-0.2
Total locomotion distance, hab. session 21.11.41.81.31.3-1.3-1.3-0.7-1.31.2-1.3-1.2-1.11.1-0.81.0
Locomotion velocity, hab. session 21.21.62.01.41.4-1.4-1.4-0.8-1.41.3-1.4-1.3-1.21.2-0.91.1
Novel to familiar place preference ratio0.00.00.2-0.00.0-0.00.00.40.0-0.10.00.10.2-0.20.3-0.2
Novelty place preference0.10.10.2-0.3-0.20.20.30.50.3-0.30.30.30.4-0.40.4-0.4
Time in novel zone, NPP test0.20.20.3-0.4-0.40.40.40.50.4-0.50.40.50.5-0.50.5-0.5
Total zone transitions, NPP test1.21.82.01.41.4-1.4-1.4-1.0-1.41.4-1.4-1.4-1.31.3-1.11.2
Total locomotion distance, NPP test1.11.52.01.41.4-1.4-1.4-0.6-1.31.2-1.4-1.3-1.21.2-0.91.0
Locomotion velocity, NPP test1.92.73.51.91.9-1.9-1.8-0.9-1.81.7-1.9-1.7-1.61.6-1.21.4
Intraocular pressure1.01.41.71.31.1-1.1-1.3-0.9-1.31.2-1.2-1.2-1.21.2-1.01.2
Delta distance traveled before/after self-admin1.31.41.7-1.3-1.31.31.11.01.0-1.31.31.21.2-1.21.1-1.3
Delta ambulatory time before/after self-admin0.40.50.7-0.7-0.90.80.80.30.7-0.70.80.60.6-0.60.3-0.8
Parametrial fat weight2.54.85.3-2.2-2.12.12.12.12.2-2.32.12.32.3-2.32.2-2.2
Pavlov. Cond. lever latency1.21.54.6-0.9-0.70.70.72.10.8-1.20.71.21.3-1.31.8-1.3
Pavlov. Cond. magazine entry latency1.51.95.01.10.9-0.9-0.9-2.2-1.01.4-0.9-1.4-1.51.5-2.01.6
Pavlov. Cond. change in total contacts0.30.30.6-0.7-0.80.80.8-0.50.7-0.40.80.40.3-0.3-0.2-0.2
Pavlov. Cond. index score1.72.16.11.10.8-0.9-0.9-2.5-1.01.5-0.9-1.4-1.61.6-2.21.7
Pavlov. Cond. latency score1.11.44.80.80.5-0.6-0.6-2.2-0.71.1-0.5-1.1-1.21.2-1.91.3
Pavlov. Cond. lever contacts0.60.63.00.40.2-0.2-0.2-1.7-0.30.7-0.2-0.7-0.80.8-1.40.8
Pavlov. Cond. magazine entry number2.22.75.0-1.5-1.31.31.32.21.4-1.71.31.71.7-1.82.1-1.8
Pavlov. Cond. intertrial magazine entries0.30.30.60.70.8-0.7-0.80.6-0.70.4-0.8-0.4-0.30.30.30.1
Pavlov. Cond. lever-magazine prob. diff.1.92.46.31.20.9-1.0-1.0-2.5-1.11.6-1.0-1.5-1.61.7-2.21.7
Pavlov. Cond. response bias2.12.66.21.31.1-1.1-1.1-2.5-1.21.7-1.1-1.6-1.71.7-2.31.8
Pavlov. Cond. lever latency0.20.30.4-0.6-0.60.60.70.30.7-0.50.60.50.5-0.50.3-0.4
Pavlov. Cond. magazine entry latency0.60.60.9-0.9-0.90.90.90.40.9-0.80.90.80.7-0.80.5-0.7
Pavlov. Cond. change in total contacts0.20.30.6-0.5-0.50.50.40.80.4-0.60.50.60.6-0.60.8-0.6
Pavlov. Cond. index score0.00.00.0-0.1-0.10.10.10.10.1-0.10.10.10.1-0.10.1-0.1
Pavlov. Cond. latency score0.10.10.1-0.3-0.30.30.30.30.3-0.40.30.30.3-0.30.3-0.3
Pavlov. Cond. lever contacts0.10.10.20.30.4-0.4-0.40.3-0.40.1-0.4-0.2-0.20.20.20.0
Pavlov. Cond. magazine entry number0.40.50.50.70.7-0.7-0.7-0.6-0.70.7-0.7-0.7-0.70.7-0.60.6
Pavlov. Cond. intertrial magazine entries1.82.34.11.41.2-1.2-1.2-2.0-1.21.6-1.2-1.5-1.61.6-2.01.8
Pavlov. Cond. lever-magazine prob. diff.0.00.00.0-0.1-0.10.10.10.10.1-0.10.10.10.1-0.10.1-0.1
Pavlov. Cond. response bias0.00.10.10.30.3-0.3-0.3-0.0-0.30.2-0.3-0.2-0.20.2-0.10.1
Time in closed arm before self-admin0.00.00.10.10.1-0.0-0.30.0-0.30.2-0.1-0.0-0.10.1-0.00.2
Time in closed arm after self-admin1.01.01.5-0.9-1.01.00.81.20.7-1.00.81.01.0-1.01.2-1.1
Time in open arm before self-admin0.30.40.90.40.6-0.6-0.4-1.0-0.30.5-0.3-0.7-0.60.6-0.90.3
Time in open arm after self-admin0.80.91.50.91.0-1.0-1.0-1.2-0.90.9-0.8-1.1-1.01.0-1.00.7
Bone: periosteal estimation2.55.17.2-2.6-2.72.62.70.82.6-2.22.72.22.1-2.11.2-1.8
Bone: periosteal perimeter0.91.52.4-1.4-1.61.51.6-0.01.5-1.11.61.11.0-1.00.3-0.8
Bone: post-yield work0.20.21.30.0-0.10.00.1-1.20.00.30.1-0.3-0.40.4-0.90.6
Progressive ratio test 1 active lever presses0.20.20.60.50.8-0.8-0.2-0.20.10.4-0.5-0.4-0.30.40.00.4
Progressive ratio test 1 breakpoint0.20.20.60.50.7-0.7-0.2-0.1-0.00.4-0.5-0.4-0.30.40.10.3
Progressive ratio test 1 inactive lever presses0.10.10.40.00.1-0.1-0.20.6-0.2-0.1-0.20.00.1-0.10.50.0
Progressive ratio test 2 active lever presses0.80.81.51.01.2-1.2-0.9-0.4-0.81.0-0.9-0.8-0.70.8-0.41.2
Progressive ratio test 2 breakpoint1.21.42.31.31.5-1.5-1.2-0.5-1.11.2-1.2-1.1-1.01.0-0.61.5
Progressive ratio test 2 inactive lever presses0.20.30.5-0.6-0.40.40.40.40.4-0.50.60.60.6-0.60.7-0.3
Incentive Sensitization - Responses0.80.81.80.90.9-0.9-1.0-0.5-1.00.9-0.9-0.8-0.80.8-0.61.3
Incentive Sensitization - Breakpoint1.01.02.11.01.0-1.0-1.1-0.6-1.11.0-1.0-0.9-0.90.9-0.81.5
Sum of active levers in priming session hrs 5-60.50.50.80.80.8-0.8-0.9-0.4-0.90.7-0.7-0.7-0.70.7-0.60.6
Progressive ratio5.66.48.5-2.6-2.42.42.82.32.9-2.62.52.52.6-2.62.5-2.2
Food seeking constrained by brief footshock0.00.00.10.20.2-0.2-0.2-0.1-0.10.1-0.2-0.2-0.20.2-0.2-0.1
Seeking ratio, punishment vs. effort5.06.17.72.52.4-2.4-2.7-2.2-2.82.5-2.5-2.5-2.52.5-2.42.1
Retroperitoneal fat weight0.51.52.0-1.2-1.11.11.21.21.3-1.31.21.21.3-1.31.4-1.4
Reaction time number correct0.20.21.4-0.3-0.10.10.11.20.1-0.50.10.40.5-0.50.8-0.5
Reaction time mean minus median0.60.84.70.20.1-0.10.0-2.2-0.00.70.0-0.6-0.80.8-1.60.9
Reaction time mean minus median AUC0.70.93.80.50.3-0.4-0.3-2.0-0.30.8-0.2-0.8-0.90.9-1.61.1
Reaction time num false alarms0.40.61.0-0.8-1.00.90.90.40.8-0.71.00.80.7-0.70.4-0.6
Reaction time num false alarms AUC0.71.01.4-1.0-1.21.21.10.61.0-1.01.21.00.9-1.00.7-0.9
Reaction time trials correct on left0.20.21.4-0.3-0.10.10.11.20.1-0.50.10.40.5-0.50.8-0.5
Reaction time trials on left0.20.21.3-0.3-0.10.20.11.10.2-0.50.10.40.5-0.50.7-0.5
Reaction time mean1.01.35.40.70.5-0.5-0.5-2.3-0.51.1-0.4-1.0-1.21.2-1.91.2
Reaction time mean AUC1.01.35.40.70.5-0.5-0.4-2.3-0.51.1-0.4-1.0-1.21.2-1.91.2
Median of all reaction times0.71.03.50.70.5-0.5-0.5-1.9-0.51.0-0.5-0.9-1.01.0-1.61.0
Reaction time omissions0.60.83.60.40.3-0.4-0.3-1.9-0.30.8-0.2-0.8-0.90.9-1.51.1
Reaction time false alarm rate0.30.40.9-0.7-0.90.90.9-0.20.8-0.50.90.60.5-0.50.1-0.5
Reaction time premature initiation rate1.52.02.2-1.4-1.31.31.41.41.4-1.51.41.51.5-1.51.4-1.3
Reaction time premature initiations2.02.84.1-1.6-1.41.41.52.01.5-1.71.51.81.8-1.81.9-1.6
Std. dev. reaction times0.50.74.50.1-0.10.00.1-2.10.10.60.2-0.5-0.70.7-1.60.8
Reaction time trials completed0.20.21.3-0.3-0.10.20.11.10.2-0.50.10.40.5-0.50.7-0.5
Reaction time trials AUC0.10.21.2-0.2-0.10.10.11.10.1-0.40.10.30.4-0.50.7-0.4
Run reversals in cocaine runway, females0.20.20.9-0.2-0.10.1-0.30.9-0.4-0.40.20.40.4-0.40.8-0.7
Run reversals in cocaine runway, males0.40.40.9-0.6-0.60.60.8-0.70.9-0.51.00.40.4-0.3-0.3-0.4
Latency to leave start box in cocaine runway0.00.00.1-0.3-0.10.10.10.20.1-0.30.20.20.2-0.20.2-0.4
Latency to leave start box in cocaine runway, F0.30.30.50.50.6-0.6-0.7-0.6-0.70.5-0.6-0.6-0.60.6-0.50.3
Latency to leave start box in cocaine runway, M1.81.72.2-1.3-1.21.21.11.51.1-1.41.31.31.4-1.41.4-1.4
Std. dev. time between licks in bursts0.30.31.9-0.1-0.30.30.3-1.40.20.30.3-0.2-0.40.4-1.10.4
Total sessions with >9 infusions0.10.10.3-0.10.2-0.10.30.20.5-0.10.20.20.2-0.20.4-0.2
Short access day 1 total inactive lever presses0.10.10.6-0.2-0.30.30.4-0.80.40.00.3-0.0-0.00.1-0.40.2
Short access day 10 total inactive lever presses0.10.10.3-0.1-0.30.3-0.0-0.5-0.2-0.00.1-0.1-0.20.1-0.60.2
Short access day 1 total infusions0.40.40.80.80.9-0.9-0.5-0.5-0.30.7-0.6-0.7-0.60.6-0.50.5
Short access day 10 total infusions0.10.10.3-0.20.0-0.00.10.40.2-0.20.30.30.4-0.30.5-0.2
Short access total infusions0.10.10.2-0.20.1-0.10.10.30.2-0.20.20.20.3-0.30.4-0.4
Short access day 1 locomotion3.94.14.72.22.1-2.1-2.1-1.8-2.02.2-2.0-2.0-2.02.0-1.82.0
Short access day 10 total locomotion0.10.10.5-0.2-0.20.3-0.0-0.7-0.20.00.30.0-0.10.1-0.50.1
Short access total locomotion0.20.20.40.50.6-0.6-0.6-0.6-0.50.5-0.3-0.4-0.40.5-0.40.4
One hour access (0.3 mA shock)0.80.91.51.01.2-1.2-1.0-0.8-0.91.0-0.9-1.0-0.90.9-0.60.9
Compulsive drug intake4.04.04.42.12.1-2.1-2.1-1.8-2.02.1-2.0-2.0-2.02.0-1.91.8
One hour access (shock baseline)0.40.50.8-0.8-0.60.60.70.40.8-0.70.90.80.8-0.70.7-0.5
Social response proportion0.00.00.1-0.2-0.10.10.2-0.40.3-0.10.20.10.1-0.1-0.1-0.1
Social responses0.20.20.4-0.5-0.50.50.50.20.5-0.50.40.40.4-0.40.3-0.6
Social time0.20.32.1-0.1-0.20.20.4-1.50.40.20.4-0.2-0.30.3-0.90.4
Soleus weight0.20.72.8-0.7-0.90.91.0-1.70.9-0.10.90.20.0-0.0-1.10.3
Bone: stiffness1.52.43.0-1.5-1.41.41.41.71.4-1.61.41.61.6-1.61.7-1.7
Tibialis anterior weight0.10.21.1-0.10.00.0-0.01.0-0.0-0.3-0.00.30.3-0.40.8-0.5
Time to tail flick, vehicle, before self-admin0.20.20.40.40.2-0.10.1-0.70.20.4-0.4-0.4-0.40.4-0.50.5
Time to tail flick, vehicle, after self-admin1.11.22.40.90.8-0.8-0.9-1.5-1.01.1-0.8-1.0-1.11.1-1.41.5
Time to tail flick, test, before self-admin0.10.10.3-0.2-0.30.20.10.50.0-0.30.10.30.3-0.30.6-0.2
Time to tail flick, test, after self-admin1.11.12.11.00.8-0.8-0.6-1.5-0.61.2-0.9-1.1-1.11.1-1.41.3
Delta time to tail flick, vehicle, before/after SA0.90.91.30.91.0-1.0-1.1-0.8-1.11.0-0.7-0.8-0.90.9-0.91.1
Delta time to tail flick, test, before/after SA1.21.01.41.11.0-1.0-0.8-1.0-0.71.2-1.0-1.1-1.11.1-1.21.1
Tibia length2.16.09.2-2.8-3.03.02.90.72.9-2.42.92.42.3-2.21.2-1.9
Ambulatory time before self-admin0.00.00.1-0.2-0.20.30.2-0.10.2-0.00.10.00.0-0.0-0.20.2
Ambulatory time after self-admin0.10.10.4-0.4-0.60.60.2-0.30.1-0.20.50.30.2-0.2-0.2-0.2
Bone: tissue strength5.25.05.4-2.3-2.22.22.22.22.2-2.32.22.32.3-2.32.3-2.2
Total heroin consumption0.00.00.00.10.1-0.1-0.2-0.2-0.20.1-0.1-0.2-0.20.1-0.20.1
Bone: trabecular number1.32.02.91.61.7-1.7-1.7-0.5-1.71.4-1.7-1.4-1.31.3-0.71.2
Bone: trabecular spacing4.05.26.5-2.5-2.52.52.51.42.5-2.32.52.32.2-2.21.6-2.1
Bone: trabecular thickness1.11.31.71.31.3-1.3-1.3-0.5-1.31.1-1.3-1.1-1.11.1-0.71.0
Bone: trabecular tissue density2.23.13.3-1.8-1.81.81.81.61.7-1.81.81.81.8-1.81.7-1.7
Water consumed over 24 hours0.00.00.1-0.0-0.10.00.0-0.30.00.10.0-0.1-0.10.1-0.20.2
Number of responses in last shaping day0.20.20.6-0.4-0.30.30.70.20.8-0.30.50.40.4-0.40.4-0.1