Hub : Genes

RT1-O1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression RT1-O1 0.21 0.15 1.4e-03 0.13 0.12 0.1 0.14 4.7e-04 1.1e-03 1.9e-03 3.7e-04
2 Adipose gene expression RT1-O1 0.38 0.12 0.0e+00 0.41 0.41 0.39 0.41 1.1e-48 7.0e-49 1.9e-46 1.7e-49
3 LHb gene expression RT1-O1 0.23 0.14 1.8e-04 0.25 0.16 0.16 0.17 1.4e-06 1.6e-04 1.4e-04 8.2e-05
4 Brain gene expression RT1-O1 0.68 0.11 0.0e+00 0.44 0.52 0.51 0.52 1.5e-44 6.7e-56 2.5e-55 1.6e-55
5 BLA gene expression RT1-O1 0.43 0.12 0.0e+00 0.34 0.42 0.41 0.42 2.1e-18 6.8e-24 1.4e-23 8.9e-24
6 PL gene expression RT1-O1 0.36 0.12 0.0e+00 0.41 0.44 0.44 0.45 1.0e-48 1.1e-52 2.7e-52 5.0e-54
7 IL gene expression RT1-O1 0.29 0.16 4.5e-05 0.09 0.15 0.09 0.13 4.1e-03 1.8e-04 3.7e-03 6.4e-04
8 IC gene expression RT1-O1 0.21 0.11 5.9e-07 0.05 0.1 0.05 0.05 3.1e-03 6.8e-05 4.7e-03 2.7e-03
9 pVTA gene expression RT1-O1 0.32 0.14 0.0e+00 0.28 0.24 0.31 0.27 2.0e-22 2.5e-19 1.7e-25 4.5e-22
10 OFC intron excision ratio chr20_2696283_2746348 0.15 0.11 7.4e-03 0.03 -0 -0.01 -0.01 7.1e-02 3.7e-01 5.0e-01 8.4e-01
11 NAcc gene expression RT1-O1 0.21 0.08 0.0e+00 0.25 0.28 0.28 0.28 4.6e-37 1.0e-41 3.0e-42 3.2e-42

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.91.53.2-0.9-0.8-0.9-1.3-1.4-1.3-1.1-1.2-1.11.8-1.2
Area under the delay curve2.12.43.61.81.41.31.51.61.91.51.51.4-1.61.6
BMI with tail1.65.68.22.92.52.32.22.22.32.52.42.6-1.72.2
BMI without tail3.711.413.13.53.63.43.43.33.53.53.53.6-2.63.2
Body weight6.126.832.04.74.64.45.55.75.55.35.35.3-5.35.2
Weight adjusted by age2.03.15.11.21.50.81.92.02.01.71.71.6-2.32.1
Bone surface0.00.10.2-0.00.10.00.40.30.20.20.20.40.10.2
Bone volume0.10.10.20.30.40.40.40.30.20.40.40.50.20.3
Breakpoint value in progressive ratio session0.40.51.2-0.9-0.50.4-0.7-0.7-0.6-0.7-0.7-0.70.3-1.1
Number of licking bursts0.40.61.0-1.0-0.9-0.9-0.7-0.6-0.8-0.8-0.8-0.80.4-0.7
Context. condit. distance diff. score8.410.214.3-3.8-3.5-3.3-3.0-3.0-3.2-3.3-3.3-3.12.8-2.7
Locomotion velocity, session 10.50.50.8-0.9-0.9-0.9-0.6-0.6-0.7-0.7-0.7-0.70.4-0.4
Locomotion distance, session 10.10.10.2-0.1-0.0-0.1-0.4-0.5-0.3-0.3-0.3-0.40.4-0.2
Locomotion velocity, session 20.00.10.1-0.3-0.3-0.3-0.2-0.1-0.1-0.2-0.2-0.3-0.30.2
Locomotion distance, session 20.20.30.5-0.5-0.5-0.5-0.6-0.6-0.5-0.5-0.5-0.70.1-0.3
Locomotion velocity, session 30.10.10.40.40.60.50.30.20.30.40.40.40.00.3
Locomotion distance, session 31.21.32.1-1.2-1.0-0.9-1.2-1.3-1.2-1.2-1.2-1.11.5-1.0
Stereotopy head waving bouts, day 31.01.22.90.50.70.71.21.31.21.01.01.0-1.71.2
Stereotopy head waving duration, day 30.91.02.40.70.70.61.11.21.10.91.00.9-1.51.1
Locomotion velocity, session 75.15.66.0-2.3-2.3-2.3-2.4-2.5-2.4-2.4-2.4-2.42.4-2.1
Locomotion distance, session 73.74.76.4-1.9-2.0-2.0-2.3-2.4-2.3-2.1-2.2-2.12.5-2.0
Stereotopy head waving bouts, day 73.03.44.71.51.71.61.91.91.91.81.81.8-2.21.9
Stereotopy head waving duration, day 72.93.55.01.51.71.62.02.02.01.81.91.8-2.21.9
Locomotion velocity, session 80.80.92.4-1.5-1.4-1.4-0.6-0.3-0.6-1.0-0.9-0.9-0.5-0.1
Locomotion distance, session 84.46.48.9-3.0-2.8-2.7-2.4-2.4-2.5-2.6-2.6-2.52.0-2.0
Degree of sensitization distance0.60.71.2-0.8-1.1-1.1-0.8-0.7-0.8-0.8-0.8-0.80.5-0.6
Degree of sensitization stereotypy1.41.51.91.01.21.11.31.31.31.21.21.2-1.41.3
Conditioned locomotion0.50.61.70.80.60.50.80.90.80.70.70.6-1.30.6
Cocaine response after cond. corrected0.50.60.7-0.7-0.6-0.6-0.8-0.8-0.8-0.7-0.8-0.70.8-0.8
Cocaine response after cond. not corrected0.00.00.1-0.2-0.2-0.10.10.20.0-0.00.00.0-0.3-0.1
Cocaine response before conditioning3.54.26.41.71.61.62.32.42.22.02.12.1-2.51.9
Saline control response2.33.14.92.22.01.91.71.61.61.91.81.9-1.01.4
Bone: connectivity density2.43.85.1-1.8-1.7-1.7-2.0-2.1-2.1-1.9-1.9-1.92.3-1.9
Bone: cortical apparent density0.60.81.41.21.11.00.60.60.80.90.90.7-0.70.8
Bone: cortical area1.72.63.31.41.41.41.71.71.71.61.61.7-1.61.8
Bone: cortical porosity0.70.80.90.80.80.80.90.90.90.90.90.9-0.70.9
Bone: cortical porosity0.40.40.60.60.40.40.80.80.70.70.70.7-0.70.7
Bone: cortical thickness4.37.18.83.02.92.82.52.42.72.82.72.7-2.02.7
Bone: cortical thickness1.51.73.71.91.61.51.11.01.21.41.41.2-0.61.1
Bone: cortical tissue density0.40.61.01.01.00.90.50.50.70.80.70.6-0.60.7
Condit. Reinf. active minus inactive responses0.80.91.3-0.8-1.0-0.9-1.0-1.0-1.0-1.0-1.0-1.00.7-1.1
Condit. Reinf. active-inactive response ratio0.10.10.30.50.30.30.10.10.20.20.20.2-0.2-0.1
Condit. Reinf. active responses1.31.61.8-1.2-1.2-1.2-1.3-1.3-1.3-1.3-1.3-1.31.2-1.3
Condit. Reinf. inactive responses1.72.13.5-1.3-1.1-1.2-1.5-1.6-1.6-1.4-1.4-1.41.9-1.3
Incentive salience index mean2.12.63.4-1.7-1.8-1.8-1.6-1.5-1.6-1.7-1.7-1.61.1-1.6
Condit. Reinf. lever presses4.05.67.6-2.8-2.7-2.7-2.3-2.2-2.3-2.5-2.4-2.41.8-2.0
Condit. Reinf. active minus inactive responses0.91.21.71.10.80.61.11.21.21.11.10.9-1.31.3
Condit. Reinf. active-inactive response ratio1.82.14.01.31.01.01.51.71.61.41.41.3-2.01.6
Condit. Reinf. active responses0.00.10.3-0.1-0.4-0.5-0.2-0.1-0.1-0.2-0.2-0.30.10.0
Condit. Reinf. inactive responses1.62.13.1-1.3-1.3-1.4-1.5-1.5-1.6-1.4-1.4-1.41.8-1.4
Condit. Reinf. lever presses0.81.11.3-1.1-1.1-1.2-1.1-1.1-1.0-1.1-1.1-1.10.9-0.7
Condit. Reinf. lever reinforcers received0.10.20.4-0.4-0.5-0.6-0.4-0.3-0.3-0.4-0.4-0.50.2-0.1
Conditioned reinforcement - actives1.22.13.21.81.71.71.41.31.11.41.41.6-1.11.0
Conditioned reinforcement - inactives1.52.23.21.61.81.21.51.41.41.51.51.4-1.41.7
Conditioned locomotion0.20.30.40.60.40.50.50.50.30.50.50.5-0.70.6
Patch foraging indifference point 0 sec0.50.92.10.81.41.40.90.70.81.01.00.9-0.10.5
Patch foraging indifference point AUC1.11.62.81.41.00.81.41.31.31.31.31.4-1.01.7
Delay disc. indifference point, 0s delay0.40.50.90.60.40.70.70.80.90.60.60.5-0.90.8
Delay disc. indifference point, 16s delay2.83.14.82.22.01.81.61.51.91.81.81.8-1.11.6
Delay disc. indifference point, 2s delay1.82.03.01.31.21.31.41.51.61.31.31.1-1.71.6
Delay disc. indifference point, 24s delay0.50.61.00.90.81.00.60.60.90.80.80.9-0.40.7
Delay disc. indifference point, 4s delay3.23.45.81.91.41.51.72.02.11.71.71.5-2.42.0
Delay disc. indifference point, 8s delay0.40.51.00.90.60.50.60.71.00.70.70.6-0.70.6
Indifference point function ln k0.40.61.1-1.0-1.0-0.8-0.8-0.7-0.7-0.8-0.8-0.70.2-0.8
Indifference point function log k0.40.61.1-1.0-1.0-0.8-0.8-0.7-0.7-0.8-0.8-0.70.2-0.8
Patch foraging total patch changes 0 sec0.71.42.81.11.71.71.20.91.01.31.21.2-0.20.7
Patch foraging total patch changes 12 sec1.21.52.51.61.51.31.21.11.21.41.31.3-0.30.9
Patch foraging total patch changes 18 sec0.40.71.51.01.21.00.60.40.50.80.80.90.70.7
Patch foraging total patch changes 24 sec0.10.21.20.40.60.6-0.2-0.4-0.20.10.10.01.1-0.4
Patch foraging total patch changes 6 sec0.91.42.81.51.71.41.10.91.11.31.21.1-0.10.9
Patch foraging time to switch 0 sec0.10.10.40.20.10.2-0.4-0.4-0.3-0.2-0.2-0.30.6-0.6
Patch foraging water rate 0 sec0.40.91.21.00.80.60.91.01.11.01.01.0-1.11.1
Patch foraging water rate 12 sec0.00.00.10.30.2-0.10.00.00.10.20.20.0-0.10.1
Patch foraging water rate 18 sec0.20.30.50.30.50.10.60.60.60.50.50.6-0.70.7
Patch foraging water rate 24 sec1.62.32.91.51.41.01.61.61.61.61.61.7-1.41.7
Patch foraging water rate 6 sec0.10.10.40.60.40.00.20.20.30.40.40.40.00.3
Seeking ratio, delayed vs. immediate footshock0.30.40.80.70.60.40.70.70.60.60.70.7-0.90.3
Distance traveled before self-admin0.10.10.4-0.5-0.2-0.10.20.20.2-0.1-0.00.1-0.70.4
Distance traveled after self-admin0.70.91.90.10.91.41.21.10.70.80.91.0-0.90.8
Extensor digitorum longus weight0.00.10.4-0.6-0.4-0.30.0-0.1-0.3-0.2-0.20.00.6-0.3
Bone: elastic displacement0.40.50.90.90.90.90.60.60.70.70.70.7-0.40.4
Bone: elastic work2.63.43.61.81.91.81.91.81.91.91.91.9-1.71.8
Bone: endosteal estimation0.51.13.20.00.00.01.31.51.10.70.81.0-1.81.1
Bone: endosteal perimeter0.51.12.9-1.7-1.6-1.6-0.5-0.4-0.9-1.0-1.0-0.80.2-0.7
Epididymis fat weight2.910.021.54.64.24.22.42.22.83.43.23.0-1.02.0
Delta time in closed arm before/after self-admin0.40.40.60.80.70.50.60.60.60.70.70.5-0.60.6
Delta time in open arm before/after self-admin0.30.30.80.40.30.70.40.60.80.40.50.6-0.90.6
Diff in mean of infusions in LGA sessions3.54.35.8-1.8-1.8-1.0-2.3-2.3-2.2-2.1-2.2-2.12.2-2.4
Delay discount exponential model param2.22.53.7-1.8-1.4-1.3-1.5-1.6-1.9-1.5-1.5-1.41.7-1.6
Extinction: sum of active levers before priming0.50.51.1-1.0-0.50.1-0.8-0.9-0.4-0.9-0.9-0.60.7-0.7
Active lever presses in extinction session 60.10.10.30.20.20.3-0.1-0.2-0.10.0-0.0-0.10.6-0.4
Bone: final force6.410.211.03.33.23.23.33.23.33.33.33.3-2.63.1
Bone: final moment5.68.99.93.03.02.93.13.03.13.13.13.1-2.42.9
Food consumed during 24 hour testing period0.30.41.30.30.20.10.70.80.60.50.50.6-1.10.9
Glucose2.23.46.6-2.5-2.6-2.5-1.5-1.3-1.6-1.9-1.9-1.90.4-1.2
Heart weight2.13.24.21.91.72.01.91.81.71.81.82.0-1.21.5
Delay discount hyperbolic model param2.32.63.9-1.8-1.4-1.4-1.5-1.6-2.0-1.6-1.6-1.41.7-1.7
Intermittent access intake day 1-15 change0.10.10.7-0.2-0.4-0.8-0.2-0.2-0.4-0.2-0.2-0.30.3-0.2
Intermittent access intake escalation0.00.00.10.30.1-0.30.20.20.10.30.20.1-0.10.2
Intermittent access intake escalation 20.20.31.8-0.5-0.7-1.3-0.10.0-0.3-0.2-0.2-0.40.00.4
Intermitt. access day 1 inactive lever presses0.10.21.1-0.40.1-0.40.40.50.10.20.3-0.1-0.81.0
Intermitt. access day 15 inactive lever presses0.61.32.50.91.00.51.31.31.01.21.21.1-0.91.6
Intermitt. access escalation Index2.83.95.2-1.7-2.0-1.7-2.2-2.1-1.8-2.1-2.1-1.91.7-2.3
Intermittent access day 1 total infusions0.20.42.30.30.51.5-0.2-0.20.1-0.1-0.10.30.3-1.0
Intermittent access day 15 total infusions0.20.31.10.80.71.10.30.20.40.40.40.5-0.3-0.5
Intermittent access terminal intake (last 3 days)0.60.71.91.11.11.40.70.60.80.80.80.8-0.60.3
Intermittent access total infusions0.40.51.80.90.91.40.50.40.80.60.60.8-0.4-0.1
Intermittent access day 1 locomotion0.20.21.40.20.10.9-0.3-0.3-0.0-0.2-0.20.1-0.1-1.2
Intermittent access day 15 total locomotion1.01.72.91.71.31.11.31.41.11.31.31.2-1.60.9
Intermittent access total locomotion1.31.52.21.51.21.41.11.21.21.21.21.2-1.50.6
Intermittent access standard deviation1.73.64.32.02.11.72.01.91.82.02.01.9-1.61.8
Left kidney weight4.721.924.34.74.34.44.94.94.94.84.84.9-4.54.2
Right kidney weight5.022.926.14.84.54.25.05.15.04.94.94.8-4.94.5
Cocaine induced anxiety0.81.11.9-1.4-1.2-1.4-1.0-0.9-0.8-1.1-1.1-1.10.5-0.8
Post-drug Anxiety0.80.91.6-1.2-1.1-1.3-1.0-0.9-0.6-0.9-0.9-0.90.8-0.5
Baseline Anxiety0.20.21.1-0.1-0.2-0.1-0.5-0.6-0.4-0.3-0.4-0.31.0-0.3
Tail length2.811.117.32.12.62.43.84.03.73.23.33.2-4.23.5
Length with tail3.917.127.22.83.12.94.85.04.54.04.24.0-5.24.2
Length without tail4.012.819.83.02.82.64.04.23.83.53.63.4-4.43.5
Times rat made contact with spout0.60.62.1-0.3-0.2-0.2-0.8-1.0-0.9-0.6-0.7-0.51.4-1.0
Lifetime Intake0.81.02.51.01.21.60.80.71.10.80.81.0-0.70.3
Liver weight, left0.10.21.5-0.4-0.4-0.40.30.50.2-0.1-0.00.0-1.2-0.1
Liver weight, right0.91.64.50.60.50.81.51.71.41.11.21.1-2.11.1
Locomotor activity0.20.31.0-0.2-0.6-1.00.60.70.30.20.30.2-0.70.9
Locomotor testing distance0.10.21.4-0.6-0.7-1.20.00.0-0.2-0.2-0.2-0.20.20.3
Locomotor testing rearing0.10.10.40.0-0.2-0.20.40.50.40.20.30.3-0.60.5
Locomotion in novel chamber0.81.01.51.20.90.91.11.01.21.01.01.1-0.60.7
Locomotion in novel chamber post-restriction0.91.42.11.41.30.51.21.21.31.31.20.9-1.21.3
Fecal boli incidents, locomotor time 10.50.81.6-1.0-0.40.1-0.8-1.0-0.9-0.9-0.9-0.21.3-1.3
Change in fecal boli incidents, locomotor task0.60.61.10.60.60.70.81.00.70.90.90.4-1.10.8
Time >=10cm from walls, locomotor time 10.20.20.70.10.30.50.60.60.30.40.40.2-0.90.6
Bouts of movement, locomotor time 11.11.32.7-0.8-1.6-1.4-1.2-1.1-0.8-1.2-1.2-0.90.9-1.0
Total resting periods, locomotor time 10.50.61.4-0.6-1.2-0.9-0.8-0.7-0.5-0.8-0.8-0.60.5-0.8
Rest time, locomotor task time 10.10.10.5-0.2-0.2-0.20.10.20.0-0.0-0.0-0.3-0.70.3
Distance moved, locomotor task time 10.50.81.50.91.10.81.00.80.60.90.91.1-0.41.2
Vertical activity count, locomotor time 10.10.30.50.60.60.20.60.50.50.70.70.7-0.30.7
Time >=10cm from walls, locomotor time 20.00.00.20.0-0.30.0-0.10.0-0.1-0.2-0.1-0.2-0.4-0.2
Bouts of movement, locomotor time 20.20.31.40.3-0.5-0.80.20.40.30.10.1-0.1-1.20.8
Total resting periods, locomotor time 20.20.41.4-0.1-0.9-1.2-0.10.20.1-0.2-0.2-0.4-1.10.4
Rest time, locomotor task time 20.91.12.6-1.3-1.5-1.6-0.9-0.7-0.7-1.2-1.1-1.0-0.0-0.9
Distance moved, locomotor task time 21.31.62.31.51.51.41.21.11.11.41.31.1-0.71.2
Vertical activity count, locomotor time 20.10.10.20.30.50.00.20.30.30.40.4-0.1-0.10.3
Light reinforcement 10.10.20.50.20.70.70.40.40.30.50.50.3-0.10.2
Light reinforcement 20.40.62.10.30.50.50.81.00.90.70.80.5-1.40.6
Bone: marrow area0.51.13.20.10.10.01.31.51.10.80.91.0-1.81.1
Bone: maximum diameter0.10.10.4-0.6-0.5-0.40.40.40.1-0.10.00.2-0.40.2
Bone: maximum force4.78.39.13.02.82.73.02.93.03.03.03.0-2.52.8
Bone: maximum moment4.17.28.02.72.52.52.82.82.82.72.82.8-2.42.7
Mean time between licks in bursts0.41.02.5-1.6-1.5-1.4-0.7-0.5-0.8-1.0-1.0-1.00.0-0.6
Mean num. licks in bursts0.10.20.60.80.70.70.20.10.20.40.40.50.30.0
Cd content in liver0.10.10.20.40.20.2-0.3-0.10.1-0.0-0.1-0.4-0.4-0.2
Co content in liver1.21.42.41.51.41.21.00.91.21.21.21.0-0.81.1
Cu content in liver1.21.43.7-0.5-0.6-0.8-1.3-1.4-1.2-1.0-1.1-1.11.9-1.3
Fe content in liver0.91.11.91.41.21.00.90.91.01.11.11.1-0.60.6
K content in liver0.20.21.2-0.2-0.1-0.4-0.2-0.4-0.3-0.2-0.20.11.10.3
Mg content in liver1.51.52.5-1.4-1.3-1.3-1.1-1.2-1.3-1.2-1.2-1.01.6-0.9
Mn content in liver3.74.16.5-2.5-2.5-2.5-1.7-1.7-2.0-2.1-2.0-1.91.7-1.4
Na content in liver0.60.71.41.21.00.80.70.60.70.90.81.10.10.7
Rb content in liver1.21.43.9-0.8-1.1-1.1-1.2-1.2-1.2-1.1-1.1-0.92.0-1.2
Se content in liver0.91.12.9-1.2-1.4-1.7-0.9-0.7-0.9-1.1-1.0-1.00.2-0.7
Sr content in liver0.30.30.50.30.40.30.60.60.50.50.50.5-0.70.5
Zn content in liver0.10.10.2-0.4-0.4-0.3-0.3-0.3-0.3-0.3-0.3-0.20.4-0.2
Bone: minimum diameter0.10.20.6-0.7-0.6-0.60.40.50.2-0.10.00.1-0.80.5
Time in familiar zone, hab. session 11.61.52.4-0.7-0.8-0.7-1.5-1.5-1.3-1.2-1.2-1.41.5-1.3
Time in novel zone, hab. session 10.60.61.10.40.30.31.01.00.80.70.80.8-1.00.8
Total zone transitions, hab. session 10.60.81.1-1.0-0.8-0.8-0.9-1.0-0.9-0.9-0.9-0.91.1-0.8
Total locomotion distance, hab. session 10.30.50.6-0.7-0.5-0.5-0.7-0.8-0.7-0.7-0.7-0.70.7-0.7
Locomotion velocity, hab. session 10.10.10.2-0.3-0.1-0.1-0.3-0.4-0.3-0.3-0.3-0.30.4-0.3
Time in familiar zone, hab. session 20.10.10.2-0.10.00.0-0.3-0.4-0.3-0.2-0.2-0.30.4-0.4
Time in novel zone, hab. session 20.20.20.30.50.30.30.50.50.40.40.50.5-0.40.4
Total zone transitions, hab. session 20.00.00.10.40.20.20.00.00.20.10.1-0.0-0.30.1
Total locomotion distance, hab. session 20.70.91.3-0.7-0.8-0.8-1.1-1.1-0.9-0.9-1.0-1.10.9-1.1
Locomotion velocity, hab. session 20.81.11.5-0.8-0.9-0.9-1.2-1.2-1.0-1.0-1.1-1.20.9-1.1
Novel to familiar place preference ratio0.10.10.10.20.30.40.20.10.10.20.20.30.30.0
Novelty place preference0.10.10.20.40.50.50.40.30.30.40.40.50.00.2
Time in novel zone, NPP test0.20.20.30.50.50.50.50.40.40.50.50.6-0.20.4
Total zone transitions, NPP test1.01.51.8-1.2-1.2-1.2-1.3-1.3-1.2-1.2-1.2-1.31.1-1.1
Total locomotion distance, NPP test0.70.91.2-0.8-0.7-0.7-1.1-1.1-1.0-0.9-1.0-1.11.1-1.1
Locomotion velocity, NPP test1.31.82.4-1.2-1.1-1.0-1.5-1.5-1.4-1.3-1.4-1.41.5-1.4
Intraocular pressure0.60.81.3-0.8-0.9-0.5-1.1-1.1-1.0-1.0-1.0-0.90.9-0.7
Delta distance traveled before/after self-admin2.12.24.71.11.62.21.71.51.21.51.61.5-1.01.1
Delta ambulatory time before/after self-admin1.21.43.00.81.21.71.31.30.91.21.21.1-1.01.0
Parametrial fat weight1.12.53.31.81.71.61.71.61.51.61.71.8-1.11.3
Pavlov. Cond. lever latency1.51.93.61.91.81.91.11.01.21.41.41.3-0.60.8
Pavlov. Cond. magazine entry latency2.43.05.0-2.1-2.2-2.2-1.6-1.4-1.6-1.8-1.8-1.80.9-1.1
Pavlov. Cond. change in total contacts0.10.10.3-0.2-0.3-0.40.30.40.20.10.10.2-0.60.5
Pavlov. Cond. index score2.63.36.0-2.3-2.3-2.4-1.6-1.4-1.7-1.9-1.8-1.90.8-1.1
Pavlov. Cond. latency score1.92.44.6-2.0-2.0-2.2-1.3-1.1-1.4-1.6-1.5-1.50.6-0.9
Pavlov. Cond. lever contacts1.21.43.0-1.7-1.7-1.7-0.9-0.8-1.0-1.3-1.2-1.10.4-0.6
Pavlov. Cond. magazine entry number3.24.05.92.32.32.41.91.81.92.12.12.1-1.31.5
Pavlov. Cond. intertrial magazine entries0.10.10.60.50.40.3-0.3-0.4-0.20.0-0.0-0.00.8-0.5
Pavlov. Cond. lever-magazine prob. diff.3.03.76.4-2.4-2.4-2.5-1.7-1.5-1.8-2.0-2.0-2.01.0-1.2
Pavlov. Cond. response bias3.24.06.5-2.4-2.5-2.5-1.8-1.7-1.9-2.1-2.1-2.11.1-1.4
Pavlov. Cond. lever latency0.20.30.40.40.40.50.70.60.50.50.50.6-0.40.4
Pavlov. Cond. magazine entry latency0.20.30.40.20.40.30.60.60.50.50.50.5-0.60.6
Pavlov. Cond. change in total contacts0.20.30.40.70.50.40.50.50.50.50.50.5-0.40.6
Pavlov. Cond. index score0.00.00.1-0.1-0.1-0.2-0.00.00.0-0.0-0.0-0.1-0.30.2
Pavlov. Cond. latency score0.00.10.20.10.20.10.20.20.20.20.20.1-0.40.4
Pavlov. Cond. lever contacts0.10.10.2-0.2-0.3-0.4-0.4-0.4-0.3-0.3-0.3-0.40.2-0.1
Pavlov. Cond. magazine entry number0.20.30.6-0.4-0.5-0.4-0.6-0.6-0.6-0.5-0.5-0.50.8-0.6
Pavlov. Cond. intertrial magazine entries1.52.33.0-1.7-1.7-1.7-1.5-1.4-1.6-1.6-1.6-1.61.1-1.3
Pavlov. Cond. lever-magazine prob. diff.0.00.00.0-0.2-0.1-0.2-0.1-0.1-0.0-0.1-0.1-0.1-0.10.1
Pavlov. Cond. response bias0.20.20.4-0.5-0.5-0.7-0.5-0.4-0.4-0.5-0.5-0.50.2-0.2
Time in closed arm before self-admin0.10.20.50.1-0.3-0.7-0.3-0.4-0.4-0.3-0.3-0.20.6-0.4
Time in closed arm after self-admin1.01.02.81.71.20.50.90.90.91.11.10.9-0.50.9
Time in open arm before self-admin0.40.40.7-0.8-0.8-0.2-0.7-0.6-0.7-0.7-0.7-0.70.4-0.6
Time in open arm after self-admin0.30.31.0-1.0-0.80.2-0.6-0.4-0.2-0.7-0.6-0.5-0.1-0.3
Bone: periosteal estimation1.22.44.40.90.90.91.91.91.71.41.51.6-2.11.7
Bone: periosteal perimeter0.20.30.9-0.00.00.00.70.80.60.40.50.6-0.90.7
Bone: post-yield work0.71.12.4-1.4-1.5-1.5-0.8-0.6-0.9-1.1-1.0-0.90.4-0.8
Progressive ratio test 1 active lever presses0.40.52.20.71.01.50.30.30.50.40.40.8-0.3-0.6
Progressive ratio test 1 breakpoint0.40.52.30.71.01.50.30.30.60.50.50.9-0.4-0.5
Progressive ratio test 1 inactive lever presses0.30.41.01.01.01.00.40.30.20.60.50.60.30.5
Progressive ratio test 2 active lever presses0.10.10.40.40.20.3-0.3-0.30.0-0.1-0.10.00.1-0.7
Progressive ratio test 2 breakpoint0.10.10.40.50.30.4-0.2-0.20.1-0.1-0.10.10.1-0.6
Progressive ratio test 2 inactive lever presses0.30.50.90.80.90.90.80.70.60.70.70.8-0.60.4
Incentive Sensitization - Responses0.40.50.8-0.4-0.5-0.9-0.8-0.8-0.7-0.8-0.8-0.90.5-0.7
Incentive Sensitization - Breakpoint0.40.50.9-0.4-0.5-0.9-0.8-0.8-0.7-0.8-0.8-0.90.6-0.7
Sum of active levers in priming session hrs 5-60.50.51.1-0.8-0.60.1-0.8-0.7-0.6-0.7-0.7-0.70.2-1.0
Progressive ratio5.58.610.53.13.03.23.03.02.83.03.02.9-2.82.5
Food seeking constrained by brief footshock0.10.10.30.1-0.10.0-0.2-0.3-0.2-0.2-0.20.10.5-0.3
Seeking ratio, punishment vs. effort4.87.07.7-2.6-2.7-2.7-2.8-2.8-2.6-2.7-2.7-2.52.7-2.3
Retroperitoneal fat weight0.52.03.01.71.41.41.51.51.41.51.51.5-1.21.1
Reaction time number correct0.30.51.41.21.00.70.50.50.60.80.70.8-0.10.7
Reaction time mean minus median0.51.33.6-1.4-1.7-1.9-0.8-0.5-0.7-1.1-1.1-1.1-0.5-0.6
Reaction time mean minus median AUC0.51.34.1-1.2-1.7-2.0-1.0-0.6-0.8-1.2-1.1-1.2-0.4-0.7
Reaction time num false alarms0.30.41.40.20.40.30.60.70.60.50.60.5-0.91.2
Reaction time num false alarms AUC0.40.71.70.40.70.60.90.90.80.70.80.7-1.01.3
Reaction time trials correct on left0.30.51.41.21.00.70.50.50.60.80.70.8-0.10.7
Reaction time trials on left0.30.51.41.21.00.60.50.50.60.80.70.8-0.20.7
Reaction time mean1.42.24.6-2.0-2.0-2.2-1.1-0.9-1.3-1.5-1.5-1.50.2-0.9
Reaction time mean AUC1.42.24.6-1.9-2.0-2.2-1.2-0.9-1.3-1.5-1.5-1.50.1-1.0
Median of all reaction times1.11.63.1-1.7-1.7-1.8-0.9-0.8-1.1-1.3-1.2-1.30.4-0.8
Reaction time omissions0.71.02.3-1.5-1.5-1.1-0.8-0.5-0.7-1.1-1.0-1.1-0.4-0.6
Reaction time false alarm rate0.10.20.6-0.4-0.00.10.40.50.30.20.20.1-0.80.7
Reaction time premature initiation rate1.62.32.81.31.51.61.61.51.51.61.61.7-1.01.5
Reaction time premature initiations2.03.64.52.02.12.01.91.81.92.02.02.1-1.21.8
Std. dev. reaction times0.61.02.5-1.4-1.6-1.6-0.6-0.3-0.6-1.0-1.0-1.0-0.7-0.4
Reaction time trials completed0.30.51.41.21.00.60.50.50.60.80.70.8-0.20.7
Reaction time trials AUC0.20.41.21.10.90.60.40.40.50.70.70.8-0.10.6
Run reversals in cocaine runway, females0.20.21.00.30.81.00.40.10.40.30.30.40.3-0.1
Run reversals in cocaine runway, males0.60.62.6-0.20.2-0.20.70.91.00.40.50.5-1.60.8
Latency to leave start box in cocaine runway0.30.31.1-0.2-0.6-1.0-0.4-0.4-0.7-0.4-0.4-0.50.5-0.3
Latency to leave start box in cocaine runway, F0.80.92.6-0.8-1.1-1.6-0.9-0.9-1.0-0.9-0.9-0.81.0-0.6
Latency to leave start box in cocaine runway, M0.70.71.51.20.70.60.90.90.50.90.90.7-0.70.7
Std. dev. time between licks in bursts0.40.51.3-1.2-1.1-1.0-0.4-0.2-0.4-0.7-0.6-0.7-0.2-0.3
Total sessions with >9 infusions0.70.81.50.91.21.20.80.81.00.80.81.0-0.80.4
Short access day 1 total inactive lever presses1.92.45.41.21.21.11.61.71.61.41.41.4-1.92.3
Short access day 10 total inactive lever presses0.20.41.1-1.0-0.5-0.7-0.4-0.5-0.9-0.6-0.5-0.60.80.2
Short access day 1 total infusions0.10.10.30.20.40.50.10.10.60.10.10.2-0.30.1
Short access day 10 total infusions0.50.71.41.01.21.20.80.60.80.70.70.8-0.40.6
Short access total infusions1.01.22.71.11.41.71.00.91.21.01.01.2-0.80.6
Short access day 1 locomotion1.01.21.7-0.8-0.9-1.0-1.2-1.3-1.2-1.2-1.2-1.21.0-1.2
Short access day 10 total locomotion0.10.20.60.40.0-0.40.40.50.30.30.30.1-0.80.6
Short access total locomotion0.00.00.00.10.10.10.00.00.10.00.00.1-0.2-0.1
One hour access (0.3 mA shock)1.21.43.3-1.1-0.7-0.3-1.2-1.3-1.3-1.2-1.2-1.01.3-1.8
Compulsive drug intake4.65.57.7-2.8-2.3-1.6-2.3-2.4-2.5-2.4-2.4-2.22.0-2.6
One hour access (shock baseline)0.50.81.41.21.11.10.80.81.00.80.80.9-0.70.4
Social response proportion0.00.00.3-0.2-0.1-0.00.20.30.10.00.0-0.1-0.50.2
Social responses0.20.30.40.70.50.40.50.60.50.50.50.4-0.60.6
Social time0.40.51.4-1.2-1.1-1.1-0.3-0.2-0.4-0.7-0.6-0.6-0.4-0.1
Soleus weight0.10.31.5-1.2-0.9-0.80.20.2-0.3-0.4-0.3-0.1-0.2-0.1
Bone: stiffness1.01.62.31.51.31.21.21.21.31.31.31.3-1.01.3
Tibialis anterior weight0.20.61.21.11.00.90.70.40.50.80.80.90.50.4
Time to tail flick, vehicle, before self-admin1.61.73.1-1.0-1.4-1.8-1.1-1.2-1.3-1.2-1.2-1.11.3-1.5
Time to tail flick, vehicle, after self-admin0.81.01.6-1.1-1.3-0.9-1.0-1.0-0.8-1.1-1.1-1.00.8-0.8
Time to tail flick, test, before self-admin0.10.10.2-0.2-0.2-0.3-0.2-0.2-0.3-0.2-0.2-0.20.5-0.4
Time to tail flick, test, after self-admin0.70.71.4-0.8-1.0-1.2-0.8-0.7-0.8-0.8-0.8-1.10.3-0.5
Delta time to tail flick, vehicle, before/after SA0.00.00.3-0.10.10.5-0.2-0.10.1-0.1-0.1-0.10.00.2
Delta time to tail flick, test, before/after SA0.30.30.6-0.2-0.5-0.7-0.7-0.6-0.6-0.5-0.5-0.80.3-0.2
Tibia length1.33.66.41.31.21.02.12.32.11.71.81.8-2.52.3
Ambulatory time before self-admin0.10.20.5-0.20.10.10.30.40.50.20.20.3-0.70.7
Ambulatory time after self-admin1.21.43.70.21.11.91.41.31.01.11.11.3-1.20.9
Bone: tissue strength4.74.86.21.92.12.32.42.22.22.32.32.5-1.52.2
Total heroin consumption0.10.10.4-0.4-0.10.60.0-0.0-0.2-0.1-0.10.1-0.2-0.4
Bone: trabecular number0.81.33.0-0.7-0.7-0.7-1.2-1.3-1.3-1.0-1.1-1.11.7-1.2
Bone: trabecular spacing2.93.85.21.61.61.62.12.22.11.92.02.1-2.31.9
Bone: trabecular thickness0.80.91.3-0.8-0.8-0.8-1.1-1.1-1.0-1.0-1.0-1.11.0-0.9
Bone: trabecular tissue density1.72.63.81.71.51.31.51.61.71.61.61.4-1.91.7
Water consumed over 24 hours0.00.00.0-0.1-0.1-0.20.0-0.0-0.1-0.1-0.10.10.2-0.0
Number of responses in last shaping day0.50.60.90.50.70.70.80.80.90.70.70.9-0.90.7