Hub : Genes

RGD1562683

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	RGD1562683	0.07	0.04	4.8e-07	0.07	0.07	0.06	0.07	7.5e-07	6.8e-07	6.0e-06	8.5e-07
2	PL	gene expression	RGD1562683	0.03	0.02	9.7e-03	0.01	0.01	0	0	4.1e-02	6.0e-02	1.9e-01	2.4e-01
3	Adipose	gene expression	RGD1562683	0.03	0.02	4.9e-04	0.03	0.02	0.02	0.02	3.0e-04	1.9e-03	1.6e-03	9.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.1	0.1	0.4	-0.6	0.2	-0.0
Area under the delay curve	0.7	0.8	1.8	-0.2	1.3	0.8
BMI with tail	0.4	1.3	2.8	-1.7	-0.6	0.9
BMI without tail	0.1	0.2	0.3	-0.5	0.5	-0.2
Body weight	0.0	0.1	0.2	-0.3	0.5	0.1
Weight adjusted by age	0.7	1.0	1.5	1.1	1.2	-0.6
Bone surface	4.5	8.2	9.7	-3.1	-2.4	3.0
Bone volume	2.3	4.1	5.6	-2.4	-1.6	2.1
Breakpoint value in progressive ratio session	0.3	0.3	0.6	-0.0	-0.8	0.6
Number of licking bursts	0.4	0.7	1.1	0.3	1.1	-0.9
Context. condit. distance diff. score	0.2	0.2	0.5	0.2	0.2	0.7
Locomotion velocity, session 1	0.1	0.1	0.2	-0.1	-0.4	0.1
Locomotion distance, session 1	1.0	1.2	2.1	-0.6	-1.1	1.4
Locomotion velocity, session 2	0.1	0.2	0.3	-0.0	-0.6	0.4
Locomotion distance, session 2	0.1	0.1	0.3	-0.0	0.3	0.6
Locomotion velocity, session 3	4.3	4.8	8.4	-1.8	-2.9	1.8
Locomotion distance, session 3	1.0	1.1	1.8	-1.4	-0.9	0.7
Stereotopy head waving bouts, day 3	1.3	1.5	3.3	-0.4	-1.8	-1.0
Stereotopy head waving duration, day 3	0.8	1.0	2.3	-0.4	-1.5	-0.7
Locomotion velocity, session 7	1.0	1.1	1.2	1.1	1.0	-1.1
Locomotion distance, session 7	1.0	1.3	2.6	0.9	1.6	-0.7
Stereotopy head waving bouts, day 7	2.1	2.4	6.1	-0.9	-2.5	0.6
Stereotopy head waving duration, day 7	2.0	2.4	5.5	-0.8	-2.3	1.0
Locomotion velocity, session 8	2.9	3.5	5.4	-1.7	-2.3	1.6
Locomotion distance, session 8	0.2	0.4	1.0	0.0	0.2	1.0
Degree of sensitization distance	1.7	1.8	2.4	1.6	1.5	-0.9
Degree of sensitization stereotypy	2.6	2.8	4.7	-1.2	-2.2	1.5
Conditioned locomotion	0.9	1.0	1.5	1.2	0.8	-0.9
Cocaine response after cond. corrected	0.1	0.2	0.3	0.6	-0.4	0.0
Cocaine response after cond. not corrected	0.1	0.2	0.5	0.7	-0.1	0.0
Cocaine response before conditioning	0.1	0.1	0.2	-0.1	0.3	0.4
Saline control response	1.5	2.0	2.6	-1.0	-1.6	1.6
Bone: connectivity density	0.9	1.5	2.5	-1.6	-0.7	1.2
Bone: cortical apparent density	0.0	0.0	0.0	0.1	0.2	-0.0
Bone: cortical area	0.3	0.4	0.9	-0.0	-1.0	0.5
Bone: cortical porosity	0.7	0.8	1.3	0.8	1.1	-0.6
Bone: cortical porosity	0.6	0.6	0.9	0.8	1.0	-0.5
Bone: cortical thickness	1.6	2.7	4.6	2.1	0.9	-1.6
Bone: cortical thickness	0.4	0.5	0.8	0.9	0.7	-0.5
Bone: cortical tissue density	0.0	0.0	0.0	0.0	0.2	-0.0
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	0.3	0.0	-0.2
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.6	0.8	0.1	-0.6
Condit. Reinf. active responses	0.0	0.0	0.1	0.2	0.1	0.3
Condit. Reinf. inactive responses	0.1	0.1	0.1	-0.2	-0.3	0.4
Incentive salience index mean	0.1	0.2	0.3	0.5	0.5	-0.2
Condit. Reinf. lever presses	0.3	0.4	0.6	0.8	0.7	-0.2
Condit. Reinf. active minus inactive responses	1.0	1.3	3.0	-0.7	-0.6	1.7
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.0	-0.4	0.4	1.0
Condit. Reinf. active responses	1.6	2.2	3.0	-0.9	-1.7	1.7
Condit. Reinf. inactive responses	1.5	1.9	4.2	-0.7	-2.0	1.0
Condit. Reinf. lever presses	0.9	1.3	1.8	-0.8	-1.4	1.2
Condit. Reinf. lever reinforcers received	1.8	2.5	3.3	-1.1	-1.8	1.8
Conditioned reinforcement - actives	1.1	1.9	3.2	1.2	1.8	-1.0
Conditioned reinforcement - inactives	2.9	4.3	7.9	2.8	0.9	-2.0
Conditioned locomotion	0.3	0.3	0.9	0.9	0.1	-0.3
Patch foraging indifference point 0 sec	1.0	1.9	3.5	1.9	0.3	-1.4
Patch foraging indifference point AUC	0.9	1.4	1.9	-0.7	-1.4	1.3
Delay disc. indifference point, 0s delay	0.6	0.6	0.8	-0.5	0.9	0.9
Delay disc. indifference point, 16s delay	0.1	0.1	0.4	-0.2	0.6	-0.0
Delay disc. indifference point, 2s delay	0.4	0.4	0.7	-0.7	0.8	0.4
Delay disc. indifference point, 24s delay	0.8	0.9	1.7	1.0	1.3	-0.3
Delay disc. indifference point, 4s delay	0.8	0.9	1.4	-0.6	0.9	1.2
Delay disc. indifference point, 8s delay	0.7	0.8	2.0	0.4	1.4	0.4
Indifference point function ln k	1.0	1.7	2.4	1.5	1.5	-0.8
Indifference point function log k	1.0	1.7	2.4	1.5	1.5	-0.8
Patch foraging total patch changes 0 sec	0.7	1.3	2.6	1.6	0.1	-1.2
Patch foraging total patch changes 12 sec	0.7	0.9	2.5	-0.1	-1.6	0.5
Patch foraging total patch changes 18 sec	0.4	0.6	1.4	-0.0	-1.2	0.6
Patch foraging total patch changes 24 sec	0.4	0.7	1.5	-0.2	-0.8	1.2
Patch foraging total patch changes 6 sec	0.7	1.1	3.1	0.4	-1.8	-0.3
Patch foraging time to switch 0 sec	0.1	0.2	0.5	-0.7	0.3	0.0
Patch foraging water rate 0 sec	0.7	1.4	3.3	-0.8	-1.8	0.5
Patch foraging water rate 12 sec	0.7	1.5	2.3	1.5	0.9	-1.1
Patch foraging water rate 18 sec	0.1	0.2	0.5	-0.7	-0.3	0.1
Patch foraging water rate 24 sec	0.2	0.3	0.5	0.6	0.7	0.2
Patch foraging water rate 6 sec	0.0	0.0	0.1	0.3	0.1	0.3
Seeking ratio, delayed vs. immediate footshock	0.8	1.0	1.7	0.0	1.1	-1.3
Distance traveled before self-admin	0.2	0.3	0.8	0.0	-0.9	0.2
Distance traveled after self-admin	0.4	0.5	0.7	-0.9	0.7	0.4
Extensor digitorum longus weight	3.9	15.3	20.3	-4.5	-3.8	3.4
Bone: elastic displacement	0.5	0.6	1.1	0.6	0.6	-1.0
Bone: elastic work	0.1	0.1	0.3	0.2	-0.2	-0.5
Bone: endosteal estimation	3.7	8.1	10.2	-3.2	-2.1	3.1
Bone: endosteal perimeter	2.3	4.8	6.3	-2.0	-2.0	2.5
Epididymis fat weight	0.6	2.0	4.3	-1.0	-0.9	2.1
Delta time in closed arm before/after self-admin	0.7	0.6	1.2	-0.8	1.1	0.2
Delta time in open arm before/after self-admin	0.4	0.4	0.7	-0.7	-0.8	0.3
Diff in mean of infusions in LGA sessions	1.6	2.0	3.9	-0.3	-2.0	1.4
Delay discount exponential model param	0.7	0.7	1.7	0.2	-1.3	-0.7
Extinction: sum of active levers before priming	0.4	0.4	0.7	0.3	-0.9	0.6
Active lever presses in extinction session 6	1.4	1.4	1.6	1.3	-1.1	-1.2
Bone: final force	0.5	0.7	1.2	-0.5	-1.1	0.8
Bone: final moment	0.5	0.8	1.3	-0.5	-1.1	0.9
Food consumed during 24 hour testing period	0.5	0.7	1.0	1.0	0.4	-0.9
Glucose	5.2	8.2	9.9	-2.7	-3.1	2.7
Heart weight	0.1	0.1	0.4	-0.1	0.7	-0.0
Delay discount hyperbolic model param	0.7	0.8	1.7	0.3	-1.3	-0.8
Intermittent access intake day 1-15 change	0.6	1.2	2.1	1.5	0.1	-1.2
Intermittent access intake escalation	0.5	0.9	1.8	1.3	0.2	-1.0
Intermittent access intake escalation 2	0.3	0.4	0.8	0.9	-0.6	-0.2
Intermitt. access day 1 inactive lever presses	0.8	3.2	5.0	2.2	1.6	-1.4
Intermitt. access day 15 inactive lever presses	0.6	1.2	3.4	1.8	-0.5	-0.3
Intermitt. access escalation Index	0.4	0.5	0.8	0.8	0.9	-0.4
Intermittent access day 1 total infusions	0.9	1.5	2.0	1.4	1.1	-1.2
Intermittent access day 15 total infusions	2.3	3.4	6.4	2.5	0.8	-1.8
Intermittent access terminal intake (last 3 days)	2.0	2.7	5.6	2.4	1.0	-1.2
Intermittent access total infusions	2.2	2.6	4.4	2.1	1.1	-1.6
Intermittent access day 1 locomotion	2.1	2.7	3.9	1.8	2.0	-1.1
Intermittent access day 15 total locomotion	0.7	1.2	3.2	1.8	-0.4	-0.5
Intermittent access total locomotion	2.6	3.1	7.1	2.7	0.9	-1.1
Intermittent access standard deviation	0.3	0.6	0.9	0.8	-1.0	-0.6
Left kidney weight	2.2	10.4	16.4	3.0	4.1	-2.5
Right kidney weight	2.1	9.7	10.4	3.1	3.2	-3.0
Cocaine induced anxiety	0.2	0.2	0.4	0.6	-0.2	-0.5
Post-drug Anxiety	0.5	0.5	0.9	-0.0	-0.7	1.0
Baseline Anxiety	0.3	0.4	0.5	-0.5	0.7	0.6
Tail length	1.3	4.9	7.0	2.6	1.6	-2.2
Length with tail	0.3	1.4	1.9	1.4	1.3	-0.8
Length without tail	0.1	0.2	0.4	-0.1	-0.4	0.7
Times rat made contact with spout	8.1	9.3	13.4	3.7	2.4	-2.9
Lifetime Intake	1.6	2.0	2.3	1.5	1.2	-1.5
Liver weight, left	6.0	9.9	10.4	3.1	3.2	-3.1
Liver weight, right	2.7	4.7	5.9	1.7	2.3	-2.4
Locomotor activity	2.0	3.1	4.9	1.9	2.2	-0.9
Locomotor testing distance	0.7	1.3	1.5	1.2	1.2	-1.0
Locomotor testing rearing	0.3	0.7	1.6	0.6	1.3	-0.2
Locomotion in novel chamber	0.1	0.1	0.3	0.5	-0.1	-0.2
Locomotion in novel chamber post-restriction	0.1	0.2	0.6	-0.7	-0.2	0.1
Fecal boli incidents, locomotor time 1	0.3	0.5	1.4	0.1	1.2	0.2
Change in fecal boli incidents, locomotor task	1.8	1.8	2.9	1.7	1.3	-0.8
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.2	1.1	0.2	-0.1
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.1	-0.5	0.1
Total resting periods, locomotor time 1	0.1	0.1	0.2	0.1	-0.4	0.2
Rest time, locomotor task time 1	1.2	1.5	3.6	-0.9	0.3	1.9
Distance moved, locomotor task time 1	0.8	1.2	3.2	0.6	0.1	-1.8
Vertical activity count, locomotor time 1	0.2	0.6	1.1	-0.0	-0.8	-1.0
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.6	-0.8	-0.5	0.4
Bouts of movement, locomotor time 2	1.8	2.9	5.9	-1.1	-1.2	2.4
Total resting periods, locomotor time 2	0.9	1.5	4.0	-0.4	-0.6	2.0
Rest time, locomotor task time 2	0.3	0.4	0.6	0.8	0.4	0.6
Distance moved, locomotor task time 2	0.4	0.5	0.9	-0.9	-0.4	-0.7
Vertical activity count, locomotor time 2	0.6	0.9	2.1	-1.5	-0.6	0.2
Light reinforcement 1	0.2	0.6	1.0	-0.8	0.4	1.0
Light reinforcement 2	3.7	5.7	7.7	-2.6	-1.7	2.8
Bone: marrow area	4.0	8.8	10.8	-3.3	-2.2	3.3
Bone: maximum diameter	1.3	2.5	3.0	-1.2	-1.7	1.7
Bone: maximum force	0.4	0.7	1.5	-0.7	-1.2	0.6
Bone: maximum moment	0.4	0.7	1.2	-0.6	-1.1	0.7
Mean time between licks in bursts	1.2	2.9	3.6	1.7	1.5	-1.9
Mean num. licks in bursts	0.7	1.0	2.5	1.6	-0.0	-0.7
Cd content in liver	0.6	0.7	1.4	-1.2	-0.8	0.3
Co content in liver	0.3	0.4	0.7	-0.5	0.5	0.8
Cu content in liver	0.3	0.3	0.5	0.6	0.4	-0.7
Fe content in liver	0.4	0.5	0.9	0.5	-1.0	-0.6
K content in liver	0.2	0.2	0.5	-0.7	-0.1	0.3
Mg content in liver	0.3	0.3	0.7	-0.8	-0.2	0.5
Mn content in liver	0.6	0.6	1.3	-0.8	-0.2	1.1
Na content in liver	4.1	4.4	4.7	-1.9	-2.2	2.2
Rb content in liver	0.6	0.7	1.2	0.6	1.1	-0.8
Se content in liver	0.7	0.8	1.7	0.9	0.2	-1.3
Sr content in liver	1.3	1.1	1.7	1.0	1.3	-0.8
Zn content in liver	0.0	0.0	0.1	0.1	0.0	-0.3
Bone: minimum diameter	4.3	7.8	8.9	-2.9	-3.0	2.5
Time in familiar zone, hab. session 1	0.1	0.1	0.3	-0.1	0.1	0.6
Time in novel zone, hab. session 1	0.3	0.3	0.6	-0.8	-0.6	-0.3
Total zone transitions, hab. session 1	0.7	1.0	1.5	1.2	1.2	-0.4
Total locomotion distance, hab. session 1	1.0	1.4	1.7	1.3	1.3	-0.9
Locomotion velocity, hab. session 1	1.1	1.5	1.9	1.3	1.4	-0.9
Time in familiar zone, hab. session 2	1.2	1.3	3.0	-0.9	-0.2	1.7
Time in novel zone, hab. session 2	0.9	0.9	2.2	0.6	0.2	-1.5
Total zone transitions, hab. session 2	0.5	0.7	1.2	0.7	1.1	0.6
Total locomotion distance, hab. session 2	1.5	2.0	4.1	1.3	2.0	-0.4
Locomotion velocity, hab. session 2	1.4	1.8	3.8	1.2	2.0	-0.3
Novel to familiar place preference ratio	0.2	0.2	0.6	-0.2	0.1	-0.8
Novelty place preference	0.2	0.2	0.4	-0.6	0.0	-0.5
Time in novel zone, NPP test	0.2	0.2	0.6	-0.7	-0.1	-0.3
Total zone transitions, NPP test	0.2	0.2	0.6	0.3	0.1	0.8
Total locomotion distance, NPP test	0.2	0.2	0.5	0.4	0.7	-0.2
Locomotion velocity, NPP test	0.3	0.4	0.7	0.6	0.8	-0.3
Intraocular pressure	0.1	0.1	0.2	-0.5	0.1	-0.4
Delta distance traveled before/after self-admin	1.4	1.5	3.5	-0.8	1.9	0.5
Delta ambulatory time before/after self-admin	1.3	1.6	3.6	-0.9	1.9	0.5
Parametrial fat weight	3.2	7.5	15.1	-3.9	-1.3	2.4
Pavlov. Cond. lever latency	0.0	0.0	0.1	-0.3	0.0	-0.1
Pavlov. Cond. magazine entry latency	0.5	0.7	0.7	0.8	0.8	-0.8
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.4	0.5	-0.2
Pavlov. Cond. index score	0.1	0.1	0.2	0.4	0.3	-0.4
Pavlov. Cond. latency score	0.2	0.2	0.2	0.5	0.5	-0.4
Pavlov. Cond. lever contacts	0.0	0.1	0.1	0.3	-0.3	0.0
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	-0.3	-0.5	0.5
Pavlov. Cond. intertrial magazine entries	3.3	3.9	8.8	-1.2	-3.0	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.1	0.3	0.2	-0.3
Pavlov. Cond. response bias	0.2	0.2	0.3	0.6	0.2	-0.5
Pavlov. Cond. lever latency	1.1	1.5	2.3	1.0	1.2	-1.5
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.4	-0.1	0.4
Pavlov. Cond. change in total contacts	0.7	1.2	1.9	-1.0	-0.8	1.4
Pavlov. Cond. index score	0.3	0.4	0.6	-0.0	-0.8	0.7
Pavlov. Cond. latency score	0.1	0.2	0.4	0.2	-0.3	0.6
Pavlov. Cond. lever contacts	1.3	1.8	2.4	-1.1	-1.3	1.6
Pavlov. Cond. magazine entry number	0.1	0.2	0.5	0.1	0.0	-0.7
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.9	-0.5	-1.0	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.5	0.1	-0.6	0.7
Pavlov. Cond. response bias	1.1	1.5	2.0	-1.0	-1.3	1.4
Time in closed arm before self-admin	0.5	0.6	1.4	-0.6	-0.3	1.2
Time in closed arm after self-admin	2.3	2.5	3.3	-1.8	1.6	1.2
Time in open arm before self-admin	0.1	0.1	0.2	0.1	0.4	-0.2
Time in open arm after self-admin	1.0	1.1	3.1	-0.2	-1.8	0.3
Bone: periosteal estimation	1.8	3.8	4.1	-1.9	-2.0	2.0
Bone: periosteal perimeter	0.9	1.6	2.4	-0.9	-1.5	1.3
Bone: post-yield work	0.7	1.0	2.2	-0.7	-1.5	0.6
Progressive ratio test 1 active lever presses	2.8	3.5	3.9	1.8	2.0	-1.8
Progressive ratio test 1 breakpoint	2.6	3.2	3.7	1.7	1.9	-1.7
Progressive ratio test 1 inactive lever presses	2.9	4.2	5.6	2.4	1.4	-2.3
Progressive ratio test 2 active lever presses	3.8	4.4	7.0	2.7	1.1	-2.3
Progressive ratio test 2 breakpoint	3.6	4.1	6.6	2.6	1.0	-2.2
Progressive ratio test 2 inactive lever presses	2.5	4.0	10.3	3.2	0.4	-1.3
Incentive Sensitization - Responses	1.3	1.8	3.8	1.9	-0.2	-1.3
Incentive Sensitization - Breakpoint	1.5	1.9	4.2	2.0	-0.2	-1.2
Sum of active levers in priming session hrs 5-6	0.5	0.4	0.8	0.6	-0.9	-0.3
Progressive ratio	0.2	0.2	0.5	-0.4	-0.7	0.1
Food seeking constrained by brief footshock	1.1	1.3	2.2	1.0	0.8	-1.5
Seeking ratio, punishment vs. effort	0.6	0.8	1.0	0.9	0.8	-1.0
Retroperitoneal fat weight	1.8	7.6	12.7	-3.6	-1.6	2.8
Reaction time number correct	0.0	0.1	0.2	0.0	-0.5	0.1
Reaction time mean minus median	0.2	0.5	1.5	1.2	0.4	-0.0
Reaction time mean minus median AUC	0.2	0.4	0.9	0.9	-0.4	0.4
Reaction time num false alarms	2.4	3.3	5.2	1.7	1.4	-2.3
Reaction time num false alarms AUC	2.1	3.3	4.1	1.5	1.8	-2.0
Reaction time trials correct on left	0.0	0.1	0.2	0.0	-0.5	0.1
Reaction time trials on left	0.1	0.1	0.3	-0.0	-0.5	0.2
Reaction time mean	0.0	0.0	0.0	-0.1	-0.0	-0.2
Reaction time mean AUC	0.0	0.0	0.0	0.2	-0.2	-0.2
Median of all reaction times	0.1	0.1	0.4	-0.6	-0.1	-0.1
Reaction time omissions	0.1	0.1	0.3	0.1	0.2	0.5
Reaction time false alarm rate	2.3	3.2	4.0	1.4	1.9	-2.0
Reaction time premature initiation rate	1.3	1.8	3.5	-1.3	-0.4	1.9
Reaction time premature initiations	0.8	1.5	3.0	-1.0	-0.7	1.7
Std. dev. reaction times	0.3	0.5	1.2	1.1	0.5	-0.4
Reaction time trials completed	0.1	0.1	0.3	-0.0	-0.5	0.2
Reaction time trials AUC	0.1	0.3	0.6	-0.3	-0.7	0.3
Run reversals in cocaine runway, females	0.7	0.7	1.6	1.3	0.7	-0.2
Run reversals in cocaine runway, males	0.2	0.2	0.3	0.3	-0.1	0.6
Latency to leave start box in cocaine runway	0.2	0.3	0.4	-0.2	0.6	0.6
Latency to leave start box in cocaine runway, F	0.3	0.3	0.9	-0.1	1.0	0.1
Latency to leave start box in cocaine runway, M	0.4	0.4	1.0	-0.1	-0.3	1.0
Std. dev. time between licks in bursts	0.5	0.6	1.4	1.2	-0.1	-0.7
Total sessions with >9 infusions	0.7	0.9	1.5	0.6	0.8	-1.2
Short access day 1 total inactive lever presses	1.4	1.8	3.0	1.7	0.2	-1.6
Short access day 10 total inactive lever presses	0.1	0.2	0.6	0.1	-0.7	-0.3
Short access day 1 total infusions	1.1	1.4	3.2	0.5	0.9	-1.8
Short access day 10 total infusions	0.6	0.7	1.2	0.1	1.0	-1.1
Short access total infusions	0.7	0.9	1.5	0.4	1.0	-1.2
Short access day 1 locomotion	1.7	2.1	3.3	1.2	1.2	-1.8
Short access day 10 total locomotion	0.2	0.3	0.9	-0.0	0.3	1.0
Short access total locomotion	0.2	0.2	0.4	0.5	0.6	0.1
One hour access (0.3 mA shock)	1.9	2.2	4.8	2.2	0.4	-1.3
Compulsive drug intake	0.7	0.8	1.2	-1.0	-0.5	1.1
One hour access (shock baseline)	2.4	3.6	6.7	2.6	0.3	-2.0
Social response proportion	0.8	0.9	1.8	1.0	1.3	-0.3
Social responses	0.7	0.9	2.4	0.6	1.5	-0.2
Social time	0.1	0.1	0.2	-0.2	-0.1	0.5
Soleus weight	1.2	3.7	5.8	-1.8	-1.4	2.4
Bone: stiffness	0.0	0.1	0.2	0.0	-0.5	-0.1
Tibialis anterior weight	7.1	24.2	32.6	-5.7	-4.7	4.2
Time to tail flick, vehicle, before self-admin	2.4	2.4	5.7	1.3	0.2	-2.4
Time to tail flick, vehicle, after self-admin	0.6	0.8	1.3	-0.9	-0.5	1.2
Time to tail flick, test, before self-admin	1.8	1.8	4.6	0.8	2.1	-0.5
Time to tail flick, test, after self-admin	0.9	0.9	2.5	0.4	1.6	0.1
Delta time to tail flick, vehicle, before/after SA	2.2	2.1	4.7	-1.1	-0.6	2.2
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	-0.1	-0.3	0.1
Tibia length	0.1	0.1	0.2	0.3	0.3	-0.5
Ambulatory time before self-admin	0.6	0.8	2.3	-0.3	-1.5	0.3
Ambulatory time after self-admin	0.5	0.6	1.4	-1.2	-0.0	0.6
Bone: tissue strength	0.5	0.5	0.8	0.7	0.9	-0.6
Total heroin consumption	0.6	0.6	1.5	1.2	0.7	0.1
Bone: trabecular number	0.1	0.2	0.3	-0.6	0.1	0.4
Bone: trabecular spacing	3.0	4.0	5.3	2.3	2.1	-1.5
Bone: trabecular thickness	0.9	1.1	1.8	-1.3	-1.0	0.7
Bone: trabecular tissue density	1.0	1.5	2.6	1.1	1.6	-0.8
Water consumed over 24 hours	0.3	0.4	0.8	0.9	0.6	-0.5
Number of responses in last shaping day	2.2	2.4	3.9	1.4	2.0	-1.2