Hub : Genes

Pym1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg gene expression Pym1 0.29 0.15 4.3e-05 0.14 0.11 0.11 0.11 1.2e-04 6.7e-04 6.9e-04 7.9e-04
2 Eye alternative polyA XM_008765035.3 0.57 0.18 1.9e-04 0.02 0.12 0.05 0.13 1.8e-01 6.3e-03 6.8e-02 4.9e-03
3 Eye alternative polyA NM_001108986.1 0.52 0.19 6.7e-04 0 0.08 0.03 0.09 2.8e-01 2.5e-02 1.1e-01 1.7e-02
4 Adipose alternative polyA NM_001108986.1 0.2 0.11 0.0e+00 0.11 0.17 0.17 0.17 2.5e-12 1.9e-18 2.2e-18 1.7e-18
5 Liver mRNA stability Pym1 0.04 0.03 1.9e-04 0.01 0.02 0.02 0.01 3.2e-02 6.2e-03 2.9e-03 2.5e-02
6 Adipose alternative polyA XM_008765034.3 0.15 0.09 6.7e-16 0.1 0.12 0.12 0.12 1.7e-11 1.4e-13 2.0e-13 1.4e-13
7 Adipose alternative polyA NM_001108986.1 0.15 0.09 3.3e-16 0.1 0.13 0.12 0.13 1.5e-11 7.4e-14 1.3e-13 7.5e-14
8 Adipose alternative polyA XM_008765034.3 0.2 0.11 0.0e+00 0.11 0.17 0.16 0.17 5.1e-12 5.2e-18 6.3e-18 5.3e-18
9 Adipose isoform ratio XM_008765034.3 0.07 0.05 5.1e-08 0.05 0.05 0.06 0.04 1.6e-06 1.6e-06 7.8e-07 9.3e-06
10 Adipose isoform ratio NM_001108986.1 0.09 0.06 4.2e-10 0.08 0.08 0.07 0.07 9.2e-09 8.9e-09 3.8e-08 6.1e-08
11 NAcc isoform ratio NM_001108986.1 0.03 0.03 4.3e-03 0.01 0.02 0.02 0.01 1.9e-02 2.8e-03 1.8e-03 1.2e-02
12 Liver alternative polyA NM_001108986.1 0.16 0.09 0.0e+00 0.14 0.15 0.14 0.14 2.5e-15 4.7e-16 5.9e-15 2.1e-15
13 Liver alternative polyA XM_008765034.3 0.19 0.11 0.0e+00 0.16 0.18 0.16 0.16 1.3e-17 4.3e-19 9.7e-18 7.9e-18
14 Brain mRNA stability Pym1 0.03 0.02 7.4e-03 0.02 0.01 0.02 0.02 4.8e-03 1.6e-02 8.8e-03 8.6e-03
15 Liver isoform ratio NM_001108986.1 0.05 0.04 2.3e-05 0.04 0.04 0.04 0.04 1.3e-05 2.4e-05 5.4e-05 5.3e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density2.84.67.40.8-0.90.91.8-2.0-2.12.1-2.22.22.5-2.32.7-2.7-2.7-2.7
Area under the delay curve0.20.20.70.0-0.60.60.3-0.4-0.20.3-0.30.30.40.90.5-0.5-0.4-0.4
BMI with tail3.09.826.0-4.9-5.15.1-3.93.53.2-3.23.0-2.7-2.1-0.3-0.90.60.70.7
BMI without tail0.92.03.9-2.0-1.61.6-1.81.71.6-1.61.6-1.4-1.30.3-0.90.90.80.8
Body weight0.62.66.7-2.4-2.62.6-1.81.71.7-1.71.6-1.3-1.20.9-0.60.50.40.4
Weight adjusted by age0.30.30.5-0.40.3-0.3-0.50.50.6-0.60.6-0.6-0.70.3-0.70.70.70.7
Bone surface6.110.817.31.6-0.60.62.9-3.2-3.43.4-3.53.43.8-4.23.9-4.0-3.9-3.9
Bone volume6.010.315.41.4-0.90.92.8-3.1-3.23.2-3.33.33.7-3.93.9-3.9-3.9-3.9
Breakpoint value in progressive ratio session0.70.83.71.31.9-1.90.8-0.6-0.50.5-0.40.60.10.2-0.40.40.20.2
Number of licking bursts2.83.35.0-2.2-1.91.9-2.22.22.1-2.12.0-1.9-1.81.0-1.31.31.41.4
Context. condit. distance diff. score0.10.20.3-0.5-0.40.4-0.50.50.5-0.50.5-0.4-0.40.1-0.30.30.20.2
Locomotion velocity, session 11.01.12.00.3-0.90.90.8-1.0-0.90.9-1.01.11.10.31.4-1.4-1.4-1.4
Locomotion distance, session 11.72.23.41.0-0.20.21.5-1.6-1.61.6-1.61.71.7-0.81.8-1.8-1.8-1.8
Locomotion velocity, session 23.33.95.11.70.7-0.62.1-2.2-2.22.3-2.32.22.3-1.62.1-2.1-2.1-2.1
Locomotion distance, session 23.54.97.52.50.9-0.92.7-2.7-2.62.6-2.62.62.4-0.42.1-2.1-2.1-2.1
Locomotion velocity, session 31.72.05.72.42.3-2.31.8-1.6-1.41.4-1.31.20.90.70.3-0.2-0.2-0.2
Locomotion distance, session 30.10.10.40.20.2-0.20.00.00.1-0.10.1-0.1-0.20.6-0.30.30.20.2
Stereotopy head waving bouts, day 33.23.77.82.82.5-2.52.4-2.3-2.22.2-2.11.91.7-0.61.1-0.9-1.0-1.0
Stereotopy head waving duration, day 32.32.75.62.22.4-2.41.8-1.8-1.81.8-1.71.51.4-1.50.9-0.7-0.8-0.8
Locomotion velocity, session 70.30.30.40.40.2-0.20.5-0.6-0.60.6-0.60.60.6-0.50.6-0.6-0.6-0.6
Locomotion distance, session 70.50.60.9-0.50.0-0.0-0.80.80.9-0.90.9-0.9-0.90.4-1.01.00.90.9
Stereotopy head waving bouts, day 71.61.82.71.40.4-0.41.6-1.6-1.51.5-1.51.61.5-0.11.4-1.3-1.4-1.4
Stereotopy head waving duration, day 71.82.23.21.40.1-0.11.7-1.8-1.71.7-1.71.71.70.21.6-1.6-1.7-1.7
Locomotion velocity, session 82.93.55.01.80.2-0.22.2-2.2-2.12.1-2.12.22.10.02.0-2.0-2.0-2.0
Locomotion distance, session 80.40.50.90.90.3-0.30.9-0.9-0.80.8-0.80.90.70.30.6-0.6-0.7-0.7
Degree of sensitization distance0.20.20.5-0.7-0.70.7-0.50.50.4-0.40.3-0.3-0.2-0.3-0.0-0.00.00.0
Degree of sensitization stereotypy0.50.51.00.2-0.80.90.6-0.6-0.50.5-0.60.70.70.60.9-0.9-1.0-1.0
Conditioned locomotion2.32.63.4-1.4-0.70.7-1.81.81.8-1.81.8-1.8-1.81.8-1.61.61.71.7
Cocaine response after cond. corrected3.03.34.9-1.9-1.21.2-2.22.22.1-2.12.1-2.0-1.91.1-1.71.61.71.7
Cocaine response after cond. not corrected3.33.75.3-2.1-1.11.0-2.32.32.2-2.22.2-2.1-2.11.0-1.81.81.81.8
Cocaine response before conditioning0.40.50.80.80.8-0.80.9-0.9-0.80.8-0.70.80.6-0.60.5-0.4-0.6-0.6
Saline control response0.40.50.7-0.7-0.80.8-0.80.80.8-0.80.8-0.7-0.70.7-0.50.50.50.5
Bone: connectivity density1.72.74.20.7-0.50.51.4-1.6-1.61.7-1.71.71.9-2.02.0-2.0-2.0-2.0
Bone: cortical apparent density0.60.81.8-1.3-1.21.2-1.21.10.9-0.90.9-0.8-0.6-0.6-0.30.30.30.3
Bone: cortical area1.01.55.0-0.5-1.41.50.2-0.5-0.70.7-0.80.81.1-2.21.5-1.6-1.5-1.5
Bone: cortical porosity0.50.52.00.30.1-0.10.5-0.6-0.70.7-0.70.70.8-1.40.8-0.8-0.8-0.8
Bone: cortical porosity0.80.93.6-0.0-0.40.40.5-0.6-0.80.8-0.80.81.0-1.91.1-1.1-1.1-1.1
Bone: cortical thickness0.40.72.5-1.2-1.61.6-0.60.50.3-0.20.2-0.10.2-1.40.6-0.7-0.6-0.6
Bone: cortical thickness0.70.81.4-1.2-0.80.9-1.11.11.1-1.11.0-1.0-0.90.4-0.70.60.70.7
Bone: cortical tissue density0.50.61.3-1.2-1.01.0-1.01.00.8-0.80.8-0.8-0.6-0.4-0.30.30.30.3
Condit. Reinf. active minus inactive responses1.01.22.41.61.6-1.51.2-1.2-1.21.2-1.21.00.9-0.70.6-0.5-0.4-0.4
Condit. Reinf. active-inactive response ratio0.20.20.80.20.9-0.9-0.00.10.0-0.00.0-0.2-0.2-0.6-0.40.40.50.5
Condit. Reinf. active responses2.53.04.92.21.7-1.62.0-2.0-2.12.1-2.01.81.8-1.11.4-1.3-1.3-1.3
Condit. Reinf. inactive responses2.22.63.61.80.8-0.81.9-1.9-1.91.9-1.91.81.8-0.41.6-1.5-1.5-1.5
Incentive salience index mean1.51.82.61.60.9-0.91.5-1.5-1.61.6-1.61.41.4-0.71.2-1.2-1.1-1.1
Condit. Reinf. lever presses2.12.94.21.3-0.40.41.7-1.8-1.81.8-1.91.92.0-0.42.0-2.0-2.0-2.0
Condit. Reinf. active minus inactive responses0.70.94.81.02.2-2.20.5-0.3-0.30.2-0.2-0.1-0.20.1-0.70.80.80.8
Condit. Reinf. active-inactive response ratio1.41.42.6-0.11.4-1.4-0.60.80.9-0.91.0-1.1-1.31.1-1.61.61.61.6
Condit. Reinf. active responses0.60.83.11.21.8-1.80.9-0.8-0.80.8-0.80.60.5-0.70.1-0.0-0.0-0.0
Condit. Reinf. inactive responses0.60.81.10.90.5-0.40.9-1.0-1.01.0-1.00.91.0-0.80.9-0.9-0.8-0.8
Condit. Reinf. lever presses0.81.15.51.62.3-2.40.9-0.7-0.70.6-0.60.30.10.4-0.40.50.60.6
Condit. Reinf. lever reinforcers received0.40.52.60.91.6-1.60.5-0.4-0.50.5-0.40.20.2-0.4-0.20.30.30.3
Conditioned reinforcement - actives0.90.96.40.20.4-0.50.5-0.6-0.80.8-0.80.60.9-2.50.9-0.8-0.8-0.8
Conditioned reinforcement - inactives1.61.82.9-1.60.0-0.1-1.71.71.5-1.51.5-1.5-1.4-1.5-1.31.31.21.2
Conditioned locomotion2.12.56.61.62.5-2.61.4-1.3-1.61.5-1.51.11.2-2.50.7-0.6-0.6-0.6
Patch foraging indifference point 0 sec1.21.95.9-2.4-2.32.3-1.61.31.2-1.21.1-0.9-0.6-1.30.0-0.2-0.2-0.2
Patch foraging indifference point AUC0.20.20.70.80.7-0.70.5-0.4-0.40.4-0.40.30.20.50.00.00.10.1
Delay disc. indifference point, 0s delay1.61.74.6-0.4-2.12.20.4-0.8-0.70.7-0.80.81.2-0.01.7-1.8-1.6-1.6
Delay disc. indifference point, 16s delay0.20.20.50.60.4-0.40.5-0.7-0.40.4-0.40.20.40.40.3-0.3-0.2-0.2
Delay disc. indifference point, 2s delay0.40.51.1-0.1-1.11.10.3-0.2-0.30.3-0.40.80.50.90.7-0.8-0.8-0.8
Delay disc. indifference point, 24s delay0.20.21.1-0.4-0.90.9-0.20.00.3-0.20.2-0.2-0.11.10.1-0.1-0.1-0.1
Delay disc. indifference point, 4s delay1.01.11.50.9-0.00.01.2-1.2-1.21.2-1.21.21.20.11.2-1.2-1.1-1.1
Delay disc. indifference point, 8s delay0.50.51.2-0.6-0.40.4-0.60.40.7-0.70.7-0.9-0.71.1-0.70.70.70.7
Indifference point function ln k0.10.11.0-0.5-0.00.0-0.40.40.3-0.30.3-0.3-0.2-1.0-0.20.10.10.1
Indifference point function log k0.10.11.0-0.5-0.00.0-0.40.40.3-0.30.3-0.3-0.2-1.0-0.20.10.10.1
Patch foraging total patch changes 0 sec1.11.85.7-2.4-2.22.1-1.61.41.2-1.21.1-1.0-0.7-1.3-0.10.0-0.1-0.1
Patch foraging total patch changes 12 sec1.41.83.2-1.8-1.31.3-1.71.71.5-1.51.5-1.5-1.30.2-1.00.91.01.0
Patch foraging total patch changes 18 sec0.00.00.1-0.3-0.20.2-0.10.10.1-0.10.1-0.1-0.10.1-0.00.00.00.0
Patch foraging total patch changes 24 sec0.20.21.0-0.7-1.01.0-0.30.20.3-0.30.2-0.1-0.00.20.2-0.3-0.3-0.3
Patch foraging total patch changes 6 sec0.71.03.2-1.8-1.61.6-1.31.21.0-0.90.9-0.8-0.6-0.9-0.10.10.10.1
Patch foraging time to switch 0 sec0.30.41.4-0.3-1.21.20.2-0.2-0.30.3-0.40.40.60.00.8-0.8-0.7-0.7
Patch foraging water rate 0 sec0.91.42.0-1.2-0.20.2-1.41.41.4-1.41.4-1.3-1.4-0.0-1.31.31.11.1
Patch foraging water rate 12 sec1.21.82.6-1.5-0.40.4-1.61.61.6-1.61.6-1.5-1.60.2-1.41.41.21.2
Patch foraging water rate 18 sec2.53.45.8-0.91.0-1.0-1.61.81.9-1.92.0-1.9-2.21.1-2.42.42.22.2
Patch foraging water rate 24 sec4.96.89.6-2.1-0.30.3-2.82.93.0-3.03.0-2.9-3.11.7-3.03.02.82.8
Patch foraging water rate 6 sec1.01.52.9-0.01.7-1.7-0.70.80.9-0.91.0-1.0-1.3-0.1-1.71.71.41.4
Seeking ratio, delayed vs. immediate footshock1.51.72.41.41.3-1.31.4-1.4-1.41.4-1.41.41.3-1.51.0-0.9-1.0-1.0
Distance traveled before self-admin0.50.61.11.10.8-0.81.0-0.9-0.80.8-0.80.90.60.20.4-0.4-0.5-0.5
Distance traveled after self-admin0.20.30.40.50.4-0.50.6-0.5-0.60.6-0.60.70.5-0.40.4-0.4-0.4-0.4
Extensor digitorum longus weight3.513.627.0-5.2-4.44.4-4.64.54.2-4.14.0-3.8-3.31.2-2.32.12.22.2
Bone: elastic displacement0.10.10.40.10.1-0.10.2-0.2-0.30.3-0.30.20.3-0.60.3-0.3-0.3-0.3
Bone: elastic work0.30.41.6-0.6-1.21.3-0.1-0.0-0.00.1-0.10.20.4-0.50.6-0.7-0.7-0.7
Bone: endosteal estimation0.30.73.6-0.8-1.21.2-0.30.1-0.10.1-0.20.20.4-1.90.8-0.8-0.8-0.8
Bone: endosteal perimeter0.91.93.50.80.4-0.31.3-1.4-1.51.5-1.51.41.5-1.91.5-1.4-1.5-1.5
Epididymis fat weight0.10.10.70.30.5-0.50.10.00.2-0.20.2-0.1-0.30.8-0.40.50.40.4
Delta time in closed arm before/after self-admin4.14.05.7-1.70.2-0.2-2.22.42.2-2.22.3-2.1-2.30.6-2.42.32.32.3
Delta time in open arm before/after self-admin0.60.63.1-0.8-1.81.8-0.50.30.5-0.50.4-0.3-0.10.80.2-0.3-0.3-0.3
Diff in mean of infusions in LGA sessions0.80.93.61.41.9-1.91.0-0.9-0.90.8-0.80.60.5-0.30.10.0-0.0-0.0
Delay discount exponential model param0.20.21.0-0.00.5-0.5-0.30.40.2-0.20.2-0.3-0.3-1.0-0.40.40.40.4
Extinction: sum of active levers before priming1.11.13.91.22.0-2.00.4-0.2-0.10.00.0-0.1-0.51.6-1.01.11.11.1
Active lever presses in extinction session 60.80.71.61.20.7-0.71.2-1.3-1.00.9-0.90.80.80.70.5-0.5-0.5-0.5
Bone: final force0.91.56.4-1.5-2.52.5-0.50.30.2-0.20.10.10.4-1.11.1-1.2-1.2-1.2
Bone: final moment0.91.46.1-1.5-2.52.5-0.50.30.2-0.10.10.10.5-1.21.1-1.2-1.2-1.2
Food consumed during 24 hour testing period0.20.20.6-0.8-0.80.8-0.50.50.4-0.30.3-0.3-0.2-0.00.0-0.00.10.1
Glucose0.81.22.9-1.7-1.71.7-1.31.21.3-1.21.2-1.0-0.90.2-0.40.40.30.3
Heart weight0.20.20.7-0.20.3-0.3-0.50.50.4-0.40.4-0.5-0.5-0.9-0.50.50.50.5
Delay discount hyperbolic model param0.20.21.00.10.7-0.7-0.20.30.2-0.20.2-0.3-0.3-1.0-0.40.50.40.4
Intermittent access intake day 1-15 change0.50.52.90.31.4-1.40.00.0-0.10.1-0.0-0.1-0.1-1.7-0.40.40.20.2
Intermittent access intake escalation1.31.22.2-0.31.5-1.5-0.80.90.9-0.90.9-1.0-1.2-0.8-1.41.41.21.2
Intermittent access intake escalation 20.90.93.00.11.7-1.7-0.30.40.5-0.50.6-0.6-0.8-0.4-1.21.21.01.0
Intermitt. access day 1 inactive lever presses1.11.22.0-0.51.3-1.3-0.91.00.9-0.91.0-1.1-1.2-0.5-1.41.41.31.3
Intermitt. access day 15 inactive lever presses0.60.63.00.41.7-1.7-0.00.20.2-0.20.3-0.3-0.6-0.3-0.91.00.80.8
Intermitt. access escalation Index1.91.65.70.60.1-0.21.0-1.1-1.31.3-1.31.21.4-2.41.5-1.5-1.3-1.3
Intermittent access day 1 total infusions0.10.10.5-0.5-0.70.7-0.30.20.0-0.0-0.0-0.10.2-0.70.4-0.4-0.2-0.2
Intermittent access day 15 total infusions0.30.31.8-0.60.3-0.3-0.60.60.5-0.50.5-0.5-0.4-1.3-0.40.40.40.4
Intermittent access terminal intake (last 3 days)0.30.33.8-0.30.0-0.0-0.0-0.1-0.20.2-0.20.20.3-2.00.4-0.4-0.4-0.4
Intermittent access total infusions0.20.21.1-0.7-0.30.3-0.60.50.4-0.40.4-0.4-0.2-1.1-0.10.10.10.1
Intermittent access day 1 locomotion0.00.00.0-0.1-0.0-0.0-0.10.10.1-0.10.1-0.2-0.10.1-0.10.10.20.2
Intermittent access day 15 total locomotion0.50.52.50.31.5-1.50.1-0.1-0.20.2-0.10.0-0.0-1.6-0.30.30.20.2
Intermittent access total locomotion0.20.20.50.50.7-0.70.4-0.4-0.50.4-0.40.30.3-0.60.2-0.2-0.2-0.2
Intermittent access standard deviation0.40.41.80.01.2-1.2-0.20.20.1-0.10.2-0.3-0.3-1.4-0.50.50.40.4
Left kidney weight0.51.52.60.4-0.90.80.9-1.0-1.11.1-1.11.21.4-1.11.6-1.6-1.6-1.6
Right kidney weight0.41.22.01.10.8-0.81.1-1.1-1.31.2-1.21.01.2-1.41.0-1.0-0.9-0.9
Cocaine induced anxiety2.02.33.51.80.7-0.71.9-1.9-1.81.8-1.81.71.7-0.21.5-1.4-1.4-1.4
Post-drug Anxiety2.42.73.91.2-0.30.31.7-1.8-1.81.8-1.81.81.9-0.72.0-2.0-1.9-1.9
Baseline Anxiety0.10.20.3-0.20.1-0.1-0.40.40.5-0.50.5-0.4-0.50.2-0.50.50.40.4
Tail length1.44.216.03.34.0-4.02.3-2.0-1.61.6-1.41.30.71.2-0.30.50.40.4
Length with tail0.72.55.82.42.2-2.22.1-2.0-1.61.6-1.61.51.10.80.6-0.4-0.5-0.6
Length without tail0.30.61.2-0.0-0.90.80.5-0.6-0.60.6-0.70.70.9-0.41.1-1.1-1.0-1.0
Times rat made contact with spout1.01.22.0-1.4-0.90.9-1.31.31.3-1.31.3-1.2-1.20.4-0.90.90.90.9
Lifetime Intake0.40.43.6-0.9-0.80.7-0.60.40.3-0.20.2-0.20.0-1.90.3-0.3-0.3-0.3
Liver weight, left1.01.63.4-1.9-1.21.1-1.71.61.4-1.41.4-1.4-1.2-0.4-0.80.80.90.9
Liver weight, right0.30.51.7-1.3-1.01.0-0.80.70.6-0.60.6-0.6-0.3-0.6-0.0-0.0-0.0-0.0
Locomotor activity2.33.66.22.31.8-1.82.5-2.4-2.22.2-2.22.11.9-0.11.4-1.3-1.3-1.3
Locomotor testing distance0.91.52.41.41.3-1.31.6-1.5-1.51.5-1.41.31.2-0.30.9-0.9-0.9-0.9
Locomotor testing rearing0.10.20.6-0.20.1-0.0-0.30.30.4-0.40.4-0.4-0.40.8-0.50.50.50.5
Locomotion in novel chamber0.10.10.6-0.6-0.20.2-0.50.60.3-0.30.3-0.1-0.2-0.8-0.10.10.10.1
Locomotion in novel chamber post-restriction1.41.74.52.12.1-2.11.6-1.4-1.21.2-1.21.20.80.50.2-0.2-0.3-0.3
Fecal boli incidents, locomotor time 11.51.72.7-1.0-0.70.7-1.31.41.5-1.51.5-1.2-1.41.6-1.31.31.21.2
Change in fecal boli incidents, locomotor task2.01.92.51.10.2-0.31.4-1.5-1.51.5-1.51.41.6-1.21.5-1.5-1.5-1.5
Time >=10cm from walls, locomotor time 10.60.61.2-0.3-1.11.10.1-0.4-0.40.4-0.50.50.7-0.71.0-1.0-1.0-1.0
Bouts of movement, locomotor time 10.20.20.70.70.8-0.80.3-0.5-0.30.3-0.30.00.1-0.2-0.10.10.20.2
Total resting periods, locomotor time 10.40.51.31.11.1-1.10.8-0.8-0.70.7-0.60.50.40.00.1-0.1-0.1-0.1
Rest time, locomotor task time 10.40.40.91.00.4-0.40.8-0.9-0.80.7-0.70.70.70.20.5-0.5-0.5-0.5
Distance moved, locomotor task time 10.60.61.8-0.5-1.01.00.1-0.2-0.40.4-0.50.50.7-1.31.0-1.1-1.0-1.0
Vertical activity count, locomotor time 10.70.72.0-1.4-0.70.7-1.11.00.9-0.90.8-1.0-0.7-1.1-0.50.40.40.4
Time >=10cm from walls, locomotor time 20.90.91.7-1.3-0.80.8-1.31.31.1-1.11.1-1.0-1.00.1-0.80.70.70.7
Bouts of movement, locomotor time 21.11.22.00.80.1-0.21.1-1.4-1.21.2-1.21.01.3-1.01.2-1.2-1.2-1.2
Total resting periods, locomotor time 21.31.42.30.90.1-0.11.2-1.5-1.31.3-1.31.11.4-1.11.4-1.4-1.3-1.3
Rest time, locomotor task time 20.60.60.90.7-0.20.20.8-0.9-0.80.8-0.90.90.9-0.21.0-1.0-1.0-1.0
Distance moved, locomotor task time 20.60.61.0-0.60.2-0.2-0.80.80.8-0.90.9-1.0-0.90.1-1.01.01.01.0
Vertical activity count, locomotor time 22.22.43.6-1.8-0.70.7-1.81.71.8-1.81.8-1.9-1.70.3-1.51.51.51.5
Light reinforcement 11.83.38.02.62.8-2.82.2-2.1-1.91.8-1.71.71.3-0.90.7-0.5-0.8-0.8
Light reinforcement 20.50.61.81.11.3-1.30.9-0.9-0.80.7-0.70.70.5-0.50.2-0.1-0.3-0.3
Bone: marrow area0.30.63.3-0.7-1.11.2-0.20.1-0.10.1-0.20.20.4-1.80.7-0.8-0.8-0.8
Bone: maximum diameter1.62.95.71.20.4-0.31.6-1.7-1.81.8-1.91.71.9-2.41.9-1.8-1.8-1.8
Bone: maximum force0.91.56.8-1.7-2.62.6-0.80.50.4-0.40.3-0.10.2-1.10.9-1.0-1.0-1.0
Bone: maximum moment0.91.56.6-1.7-2.62.6-0.70.50.4-0.40.3-0.10.3-1.20.9-1.0-1.0-1.0
Mean time between licks in bursts0.30.42.20.81.5-1.50.3-0.2-0.30.3-0.3-0.0-0.0-0.4-0.40.40.60.6
Mean num. licks in bursts0.50.71.11.01.0-1.01.0-1.0-0.90.9-0.90.90.7-0.40.5-0.5-0.6-0.6
Cd content in liver0.10.20.6-0.3-0.80.8-0.60.50.2-0.20.1-0.3-0.0-0.30.1-0.20.10.1
Co content in liver0.40.42.20.91.5-1.50.3-0.2-0.20.2-0.2-0.1-0.1-0.1-0.50.50.70.7
Cu content in liver0.81.04.8-0.7-1.01.0-0.0-0.2-0.40.4-0.50.50.8-2.21.1-1.2-1.3-1.3
Fe content in liver0.60.71.0-1.0-0.40.4-1.01.01.0-1.01.0-0.9-0.90.3-0.80.80.70.7
K content in liver1.31.31.61.00.6-0.61.1-1.2-1.31.3-1.31.21.3-1.21.1-1.1-1.1-1.1
Mg content in liver1.51.62.11.0-0.10.11.3-1.4-1.41.4-1.41.41.5-1.01.4-1.4-1.4-1.4
Mn content in liver4.55.17.71.5-0.10.12.3-2.4-2.42.4-2.42.52.6-1.92.6-2.6-2.8-2.8
Na content in liver0.30.30.60.1-0.50.50.5-0.5-0.40.4-0.40.60.50.60.7-0.7-0.8-0.8
Rb content in liver1.01.26.6-0.5-0.80.80.2-0.4-0.70.7-0.80.61.1-2.61.3-1.4-1.3-1.3
Se content in liver0.10.10.10.30.1-0.10.3-0.3-0.30.3-0.30.30.30.00.3-0.3-0.2-0.2
Sr content in liver1.11.01.8-0.21.0-1.0-0.50.70.8-0.80.9-1.0-1.10.7-1.31.31.31.3
Zn content in liver1.51.73.50.71.9-1.9-0.30.50.6-0.60.7-0.9-1.21.4-1.61.71.81.8
Bone: minimum diameter0.61.14.7-0.2-0.80.80.4-0.5-0.70.7-0.80.81.0-2.21.2-1.2-1.2-1.2
Time in familiar zone, hab. session 11.51.45.51.92.3-2.31.3-1.1-0.90.9-0.80.70.30.9-0.30.40.30.3
Time in novel zone, hab. session 11.31.35.1-1.3-2.22.3-0.50.30.1-0.0-0.10.20.5-1.31.1-1.2-1.2-1.2
Total zone transitions, hab. session 11.52.02.81.30.0-0.01.6-1.7-1.61.6-1.61.71.7-0.21.6-1.6-1.6-1.6
Total locomotion distance, hab. session 14.05.77.72.20.7-0.72.7-2.8-2.82.8-2.82.72.7-1.22.6-2.5-2.5-2.5
Locomotion velocity, hab. session 13.14.46.12.21.0-1.02.4-2.5-2.42.4-2.42.42.3-0.92.1-2.1-2.1-2.1
Time in familiar zone, hab. session 21.51.57.21.82.7-2.71.0-0.7-0.60.6-0.50.3-0.00.6-0.70.80.80.8
Time in novel zone, hab. session 21.71.77.5-1.8-2.72.7-0.90.60.5-0.40.3-0.10.2-1.00.9-1.1-1.0-1.0
Total zone transitions, hab. session 21.31.73.30.0-1.31.30.8-1.0-1.01.0-1.11.21.4-0.81.8-1.8-1.8-1.8
Total locomotion distance, hab. session 21.21.62.11.10.0-0.01.4-1.4-1.41.4-1.41.51.4-0.21.4-1.4-1.4-1.4
Locomotion velocity, hab. session 21.72.33.21.3-0.00.01.7-1.7-1.71.7-1.71.81.8-0.31.8-1.8-1.8-1.8
Novel to familiar place preference ratio1.21.35.0-1.1-2.22.2-0.20.0-0.10.1-0.20.40.6-0.81.2-1.3-1.3-1.3
Novelty place preference1.01.03.3-0.8-1.81.8-0.1-0.1-0.20.3-0.30.50.7-0.91.2-1.2-1.3-1.3
Time in novel zone, NPP test1.01.03.9-1.1-2.02.0-0.30.1-0.00.0-0.10.30.5-1.01.0-1.1-1.2-1.2
Total zone transitions, NPP test0.40.51.4-0.1-1.21.20.3-0.4-0.30.4-0.40.60.60.30.9-0.9-0.9-0.9
Total locomotion distance, NPP test0.81.01.90.5-0.80.80.8-1.0-0.90.9-1.01.11.1-0.31.3-1.3-1.4-1.4
Locomotion velocity, NPP test0.81.11.80.7-0.50.51.1-1.1-1.11.1-1.11.21.2-0.11.3-1.3-1.3-1.3
Intraocular pressure0.81.14.10.20.9-0.9-0.30.40.8-0.80.9-0.7-1.12.0-1.41.41.31.3
Delta distance traveled before/after self-admin0.10.10.4-0.1-0.10.1-0.00.2-0.10.2-0.20.20.2-0.60.3-0.3-0.1-0.1
Delta ambulatory time before/after self-admin0.30.30.60.0-0.30.30.3-0.2-0.50.5-0.50.60.7-0.80.8-0.8-0.6-0.6
Parametrial fat weight0.00.10.20.10.4-0.4-0.10.10.2-0.20.2-0.2-0.3-0.1-0.40.40.40.3
Pavlov. Cond. lever latency0.91.21.8-0.80.2-0.3-1.01.11.2-1.21.2-1.2-1.30.6-1.31.41.31.3
Pavlov. Cond. magazine entry latency0.50.62.31.31.5-1.50.9-0.8-0.70.7-0.70.50.4-0.1-0.00.10.10.1
Pavlov. Cond. change in total contacts0.10.10.5-0.3-0.40.4-0.20.20.0-0.00.0-0.00.1-0.70.2-0.2-0.2-0.2
Pavlov. Cond. index score0.70.91.31.10.4-0.41.1-1.1-1.11.1-1.11.11.1-0.41.0-0.9-0.9-0.9
Pavlov. Cond. latency score1.21.52.11.20.3-0.31.4-1.4-1.41.4-1.41.41.4-0.71.3-1.3-1.3-1.3
Pavlov. Cond. lever contacts1.41.62.70.8-0.50.51.2-1.3-1.31.3-1.31.41.5-0.61.6-1.6-1.6-1.6
Pavlov. Cond. magazine entry number0.20.30.8-0.9-0.80.8-0.60.60.6-0.50.5-0.5-0.40.0-0.20.10.10.1
Pavlov. Cond. intertrial magazine entries0.40.50.9-0.10.6-0.7-0.50.60.6-0.60.6-0.7-0.80.4-0.90.91.01.0
Pavlov. Cond. lever-magazine prob. diff.0.81.01.41.20.6-0.61.2-1.2-1.21.2-1.21.11.1-0.50.9-0.9-0.9-0.9
Pavlov. Cond. response bias0.40.41.21.10.9-0.90.8-0.8-0.70.7-0.70.60.50.20.3-0.3-0.3-0.3
Pavlov. Cond. lever latency0.60.92.1-1.5-1.31.3-1.21.11.0-1.01.0-0.8-0.7-0.3-0.40.30.20.2
Pavlov. Cond. magazine entry latency1.21.32.81.71.6-1.61.4-1.3-1.31.3-1.31.11.0-0.40.6-0.5-0.5-0.5
Pavlov. Cond. change in total contacts0.30.41.50.81.2-1.20.6-0.6-0.60.6-0.50.40.4-0.10.1-0.00.00.0
Pavlov. Cond. index score0.81.03.01.51.7-1.71.2-1.1-1.11.1-1.00.80.7-0.20.3-0.2-0.2-0.2
Pavlov. Cond. latency score1.01.32.71.61.6-1.61.4-1.3-1.31.3-1.21.00.9-0.10.5-0.4-0.4-0.4
Pavlov. Cond. lever contacts0.40.62.21.21.5-1.50.8-0.7-0.70.6-0.60.40.30.4-0.00.10.20.2
Pavlov. Cond. magazine entry number1.11.32.6-1.6-1.61.6-1.41.31.3-1.31.3-1.1-1.00.6-0.60.50.50.5
Pavlov. Cond. intertrial magazine entries0.91.21.8-1.3-0.90.9-1.31.31.3-1.31.3-1.2-1.20.6-1.00.90.90.9
Pavlov. Cond. lever-magazine prob. diff.1.01.23.11.61.7-1.81.3-1.2-1.21.2-1.21.00.9-0.50.4-0.4-0.3-0.3
Pavlov. Cond. response bias0.70.93.61.51.9-1.91.0-0.9-0.80.8-0.80.60.40.0-0.10.10.20.2
Time in closed arm before self-admin0.80.91.60.3-1.01.00.7-0.6-0.80.8-0.81.21.0-0.41.3-1.3-1.3-1.3
Time in closed arm after self-admin0.20.21.4-0.6-0.20.1-0.40.80.3-0.30.30.2-0.2-1.2-0.10.1-0.0-0.0
Time in open arm before self-admin0.50.52.00.11.4-1.4-0.1-0.20.0-0.10.1-0.7-0.3-1.2-0.50.60.50.5
Time in open arm after self-admin0.90.92.4-1.2-1.11.0-1.10.61.1-1.11.1-1.5-0.90.6-0.70.60.70.7
Bone: periosteal estimation0.91.97.0-0.7-1.71.70.1-0.4-0.70.7-0.80.81.2-2.61.6-1.7-1.6-1.6
Bone: periosteal perimeter1.32.15.30.4-0.40.41.1-1.2-1.41.4-1.41.41.6-2.31.7-1.8-1.8-1.8
Bone: post-yield work0.10.20.6-0.8-0.70.7-0.50.50.4-0.40.4-0.4-0.2-0.4-0.10.00.00.0
Progressive ratio test 1 active lever presses0.60.61.7-1.3-0.90.9-1.11.00.8-0.80.8-0.8-0.6-1.0-0.30.30.30.3
Progressive ratio test 1 breakpoint0.60.61.7-1.3-1.01.0-1.00.90.7-0.70.7-0.7-0.5-1.1-0.20.10.20.2
Progressive ratio test 1 inactive lever presses0.60.67.5-0.10.8-0.90.0-0.1-0.30.3-0.30.10.3-2.70.2-0.2-0.3-0.3
Progressive ratio test 2 active lever presses0.20.32.3-0.8-0.40.3-0.50.40.3-0.30.3-0.3-0.1-1.50.0-0.1-0.1-0.1
Progressive ratio test 2 breakpoint0.40.43.9-0.2-0.10.10.1-0.3-0.40.4-0.40.40.5-2.00.6-0.7-0.6-0.6
Progressive ratio test 2 inactive lever presses0.40.45.2-0.3-0.10.1-0.1-0.1-0.20.2-0.20.20.3-2.30.4-0.5-0.5-0.5
Incentive Sensitization - Responses0.20.20.90.20.6-0.60.2-0.3-0.30.3-0.30.20.2-1.00.1-0.1-0.1-0.1
Incentive Sensitization - Breakpoint0.30.31.40.40.7-0.70.5-0.5-0.50.5-0.50.40.5-1.20.4-0.4-0.4-0.4
Sum of active levers in priming session hrs 5-60.10.10.40.50.6-0.60.3-0.1-0.20.2-0.20.50.00.2-0.10.10.10.1
Progressive ratio0.70.81.9-1.4-0.80.8-1.21.21.0-1.01.0-0.9-0.8-0.4-0.60.50.50.6
Food seeking constrained by brief footshock0.70.82.51.51.2-1.21.2-1.1-0.80.8-0.70.70.51.60.2-0.1-0.1-0.1
Seeking ratio, punishment vs. effort1.01.23.31.81.4-1.41.5-1.4-1.11.1-1.00.90.71.30.3-0.2-0.3-0.3
Retroperitoneal fat weight1.34.39.3-3.1-2.72.7-2.62.52.4-2.32.3-2.0-1.8-0.0-1.21.00.90.9
Reaction time number correct1.42.02.7-1.4-0.90.9-1.61.61.6-1.61.6-1.5-1.51.2-1.31.31.31.3
Reaction time mean minus median0.70.92.51.61.2-1.21.2-1.1-1.11.1-1.00.90.8-0.00.5-0.5-0.4-0.4
Reaction time mean minus median AUC2.63.34.62.10.6-0.62.1-2.1-2.12.1-2.12.02.1-0.81.9-1.8-1.7-1.7
Reaction time num false alarms0.40.61.1-1.1-0.80.8-0.90.90.9-0.90.8-0.8-0.70.3-0.50.50.50.5
Reaction time num false alarms AUC0.81.01.6-1.3-0.70.7-1.31.21.2-1.21.2-1.1-1.10.5-0.90.80.80.8
Reaction time trials correct on left1.42.02.7-1.4-0.90.9-1.61.61.6-1.61.6-1.5-1.51.2-1.31.31.31.3
Reaction time trials on left1.21.72.4-1.4-0.90.9-1.51.51.5-1.51.5-1.4-1.41.1-1.21.21.21.2
Reaction time mean1.42.03.11.80.7-0.71.7-1.7-1.71.7-1.71.61.6-0.31.3-1.3-1.2-1.2
Reaction time mean AUC1.01.42.01.30.3-0.31.3-1.4-1.41.4-1.41.31.4-0.51.3-1.2-1.1-1.1
Median of all reaction times1.01.31.91.30.4-0.31.4-1.4-1.41.4-1.41.31.3-0.31.2-1.2-1.1-1.1
Reaction time omissions0.10.20.50.20.00.00.3-0.3-0.40.4-0.50.40.5-0.70.5-0.5-0.5-0.5
Reaction time false alarm rate0.00.00.2-0.4-0.50.4-0.20.20.1-0.10.1-0.10.0-0.10.1-0.1-0.1-0.1
Reaction time premature initiation rate0.60.82.80.91.7-1.70.3-0.10.1-0.10.2-0.2-0.61.2-1.01.01.01.0
Reaction time premature initiations1.21.73.20.11.3-1.2-0.60.81.0-1.01.1-1.1-1.41.8-1.71.81.71.7
Std. dev. reaction times0.91.22.21.50.6-0.61.3-1.3-1.31.3-1.31.21.2-0.41.0-1.0-0.9-0.9
Reaction time trials completed1.21.72.4-1.4-0.90.9-1.51.51.5-1.51.5-1.4-1.41.1-1.21.21.21.2
Reaction time trials AUC1.62.33.2-1.5-0.90.9-1.71.71.8-1.81.8-1.6-1.71.3-1.51.41.41.4
Run reversals in cocaine runway, females1.41.32.31.51.0-1.01.5-1.5-1.41.4-1.41.21.2-0.30.9-0.9-0.7-0.8
Run reversals in cocaine runway, males1.91.83.21.81.5-1.51.7-1.7-1.51.5-1.51.41.2-0.50.9-0.8-0.9-0.9
Latency to leave start box in cocaine runway1.31.42.70.3-1.01.00.9-1.0-1.11.1-1.21.31.4-0.61.6-1.7-1.6-1.5
Latency to leave start box in cocaine runway, F2.52.85.20.5-1.31.31.3-1.5-1.51.6-1.61.81.9-0.52.2-2.3-2.2-2.1
Latency to leave start box in cocaine runway, M0.70.71.0-0.60.2-0.2-0.90.90.8-0.80.9-0.9-0.90.2-1.01.01.01.0
Std. dev. time between licks in bursts1.51.82.81.10.7-0.71.3-1.3-1.61.6-1.61.31.6-1.71.5-1.5-1.3-1.3
Total sessions with >9 infusions1.71.912.6-0.0-0.30.20.6-0.8-1.01.0-1.11.01.3-3.51.5-1.5-1.5-1.5
Short access day 1 total inactive lever presses0.20.22.4-0.10.4-0.40.0-0.1-0.10.1-0.10.10.1-1.50.1-0.1-0.2-0.2
Short access day 10 total inactive lever presses0.70.71.1-0.51.0-1.0-0.80.90.7-0.80.8-0.8-0.9-0.9-1.01.00.90.9
Short access day 1 total infusions1.71.913.9-0.5-0.70.70.3-0.5-0.80.8-0.80.81.1-3.71.4-1.5-1.5-1.5
Short access day 10 total infusions0.30.43.4-0.9-0.50.5-0.60.50.3-0.20.2-0.3-0.0-1.90.2-0.2-0.1-0.1
Short access total infusions1.11.29.0-0.9-1.21.2-0.2-0.0-0.20.2-0.30.40.7-3.01.0-1.1-1.1-1.1
Short access day 1 locomotion0.70.84.30.30.4-0.40.6-0.6-0.90.9-0.90.60.9-2.10.9-0.9-0.7-0.7
Short access day 10 total locomotion0.91.05.80.82.4-2.40.4-0.2-0.40.3-0.30.0-0.1-1.3-0.50.60.50.5
Short access total locomotion0.50.52.80.40.8-0.80.5-0.5-0.60.6-0.60.40.6-1.70.4-0.4-0.4-0.4
One hour access (0.3 mA shock)0.10.20.4-0.6-0.50.5-0.50.40.5-0.50.4-0.3-0.3-0.4-0.20.10.00.0
Compulsive drug intake0.10.10.6-0.3-0.70.7-0.20.10.3-0.30.2-0.1-0.10.5-0.0-0.0-0.1-0.1
One hour access (shock baseline)0.40.40.8-0.70.4-0.4-0.80.80.6-0.60.6-0.7-0.6-0.9-0.60.60.70.7
Social response proportion0.80.91.61.20.5-0.61.3-1.2-1.01.0-1.01.10.90.80.8-0.7-0.7-0.7
Social responses5.36.814.33.82.9-3.03.4-3.2-3.03.0-2.92.72.40.31.7-1.5-1.5-1.5
Social time0.71.01.8-1.4-1.21.2-1.21.21.1-1.11.1-1.0-0.90.5-0.60.50.60.6
Soleus weight2.88.221.7-4.3-4.64.7-3.53.23.0-2.92.8-2.5-2.00.7-0.90.70.80.8
Bone: stiffness1.32.18.6-2.3-2.92.9-1.41.21.0-1.00.9-0.7-0.3-1.10.4-0.6-0.5-0.5
Tibialis anterior weight0.51.95.3-2.1-2.32.3-1.61.51.3-1.31.2-1.2-0.80.6-0.30.20.40.4
Time to tail flick, vehicle, before self-admin3.94.07.91.81.1-1.12.1-1.5-2.22.2-2.22.82.1-2.51.9-1.8-2.0-2.0
Time to tail flick, vehicle, after self-admin0.50.50.90.10.7-0.7-0.30.20.5-0.50.6-0.8-0.80.9-0.91.01.01.0
Time to tail flick, test, before self-admin2.22.13.01.40.5-0.51.6-1.7-1.71.7-1.71.41.7-1.21.5-1.5-1.4-1.4
Time to tail flick, test, after self-admin1.01.11.80.7-0.10.11.0-0.9-1.11.1-1.11.41.2-1.01.2-1.2-1.2-1.2
Delta time to tail flick, vehicle, before/after SA3.83.78.5-1.4-1.01.0-1.81.52.1-2.12.1-2.5-2.12.9-1.91.92.02.0
Delta time to tail flick, test, before/after SA0.50.41.7-0.00.4-0.3-0.30.60.6-0.60.6-0.3-0.71.3-0.80.80.70.7
Tibia length0.30.82.81.51.7-1.71.0-0.9-0.70.7-0.70.60.30.8-0.10.20.20.2
Ambulatory time before self-admin0.10.10.30.40.5-0.50.5-0.6-0.40.3-0.30.30.20.00.1-0.1-0.2-0.2
Ambulatory time after self-admin0.10.10.20.20.2-0.20.3-0.2-0.30.3-0.30.50.3-0.30.3-0.3-0.3-0.3
Bone: tissue strength1.31.24.4-1.9-2.12.1-1.21.10.9-0.90.8-0.7-0.4-0.80.2-0.3-0.2-0.2
Total heroin consumption1.31.63.21.81.4-1.41.7-1.5-1.41.4-1.41.41.10.30.7-0.7-0.7-0.7
Bone: trabecular number2.13.34.41.60.2-0.22.0-2.1-2.12.1-2.12.02.1-1.12.0-2.0-1.9-1.9
Bone: trabecular spacing3.84.97.6-1.30.6-0.6-2.22.32.4-2.42.4-2.4-2.61.4-2.72.82.62.6
Bone: trabecular thickness6.57.813.11.1-1.31.32.3-2.5-2.72.8-2.82.83.2-2.93.6-3.6-3.5-3.5
Bone: trabecular tissue density3.75.29.7-3.1-2.52.5-2.92.82.6-2.62.6-2.4-2.20.1-1.51.41.41.4
Water consumed over 24 hours0.60.71.8-0.6-1.21.20.1-0.3-0.40.4-0.50.50.7-1.31.1-1.1-1.1-1.1
Number of responses in last shaping day0.91.04.80.81.7-1.70.7-0.7-0.80.8-0.70.50.6-2.20.3-0.2-0.2-0.2