Pym1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	RMTg	gene expression	Pym1	0.32	0.16	1.7e-05	0.12	0.15	0.15	0.13	3.8e-04	8.4e-05	1.0e-04	2.1e-04
2	Liver	mRNA stability	Pym1	0.06	0.04	4.4e-06	0.04	0.04	0.04	0.03	1.6e-05	4.3e-05	2.7e-05	1.2e-04
3	Adipose	isoform ratio	NM_001108986.1	0.16	0.09	5.6e-17	0.11	0.13	0.13	0.12	3.3e-12	2.7e-14	6.3e-14	1.3e-13
4	pVTA	isoform ratio	NM_001108986.1	0.06	0.04	3.3e-05	0.04	0.05	0.05	0.05	3.1e-04	3.5e-05	1.0e-04	1.4e-04
5	Adipose	isoform ratio	XM_063264012.1	0.13	0.08	3.3e-13	0.09	0.1	0.1	0.1	5.5e-10	2.6e-11	6.4e-11	1.2e-10
6	Brain	mRNA stability	Pym1	0.03	0.02	6.2e-03	0.01	0	0	0	3.0e-02	2.5e-01	1.0e-01	2.0e-01
7	Liver	isoform ratio	NM_001108986.1	0.14	0.09	1.2e-13	0.11	0.12	0.11	0.11	1.3e-12	1.3e-13	2.1e-12	2.1e-12
8	NAcc	isoform ratio	NM_001108986.1	0.03	0.02	3.5e-05	0.03	0.03	0.03	0.03	1.3e-05	3.1e-05	1.3e-05	3.3e-05
9	NAcc	mRNA stability	Pym1	0.03	0.03	4.5e-03	0.02	0.01	0.01	0.01	6.7e-04	4.6e-03	2.8e-03	3.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	2.3	4.3	6.4	-0.0	-0.8	2.1	2.1	-2.3	-2.5	2.4	-2.3	-2.3
Area under the delay curve	0.1	0.1	0.2	0.3	0.4	0.1	0.2	-0.2	-0.0	0.2	-0.4	-0.4
BMI with tail	2.7	9.4	32.4	5.7	5.4	-2.7	-2.7	2.1	1.1	-1.1	1.0	1.0
BMI without tail	0.5	2.5	7.8	2.8	2.7	-1.5	-1.4	1.2	0.7	-0.7	0.6	0.6
Body weight	0.7	3.0	7.5	2.6	2.7	-1.8	-1.7	1.5	1.1	-1.1	1.0	1.0
Weight adjusted by age	0.0	0.1	0.1	-0.2	-0.1	-0.2	-0.2	0.2	-0.1	-0.3	0.3	0.3
Bone surface	5.3	10.4	13.6	-0.8	-2.1	3.5	3.4	-3.6	-3.6	3.7	-3.6	-3.6
Bone volume	5.0	10.0	13.5	-0.5	-1.7	3.4	3.3	-3.5	-3.6	3.7	-3.6	-3.6
Breakpoint value in progressive ratio session	0.2	0.3	1.3	-1.2	-0.9	0.3	0.2	-0.1	0.6	-0.1	0.2	0.2
Number of licking bursts	0.9	2.6	5.2	2.1	2.3	-1.7	-1.7	1.6	1.0	-1.2	1.2	1.2
Context. condit. distance diff. score	0.1	0.1	0.4	0.6	0.6	-0.4	-0.3	0.3	0.0	-0.2	0.2	0.2
Locomotion velocity, session 1	1.4	1.6	2.5	0.3	-0.0	1.2	1.3	-1.3	-1.6	1.5	-1.6	-1.6
Locomotion distance, session 1	2.1	2.7	3.5	-0.5	-0.9	1.8	1.8	-1.8	-1.9	1.8	-1.9	-1.9
Locomotion velocity, session 2	3.7	4.4	5.3	-1.4	-1.9	2.3	2.3	-2.3	-2.1	2.1	-2.2	-2.2
Locomotion distance, session 2	3.6	5.1	6.4	-2.0	-2.2	2.5	2.5	-2.4	-2.2	2.1	-2.1	-2.1
Locomotion velocity, session 3	1.3	1.5	6.0	-2.4	-2.2	1.0	1.0	-0.7	-0.4	0.3	-0.4	-0.4
Locomotion distance, session 3	0.0	0.0	0.1	-0.2	-0.1	-0.1	-0.1	0.2	-0.0	-0.2	0.2	0.2
Stereotopy head waving bouts, day 3	2.6	3.1	8.3	-2.8	-2.9	1.7	1.7	-1.5	-0.9	1.0	-1.0	-1.0
Stereotopy head waving duration, day 3	1.9	2.3	6.8	-2.5	-2.6	1.5	1.4	-1.2	-0.7	0.8	-0.8	-0.8
Locomotion velocity, session 7	0.3	0.4	0.6	-0.3	-0.4	0.6	0.6	-0.6	-0.8	0.6	-0.7	-0.7
Locomotion distance, session 7	0.5	0.7	0.9	0.4	0.6	-0.9	-0.9	0.9	0.7	-0.9	0.9	0.9
Stereotopy head waving bouts, day 7	1.8	2.1	2.7	-1.0	-1.2	1.6	1.6	-1.6	-1.3	1.5	-1.5	-1.5
Stereotopy head waving duration, day 7	2.3	2.9	3.6	-1.0	-1.2	1.9	1.9	-1.9	-1.5	1.8	-1.9	-1.9
Locomotion velocity, session 8	3.3	4.0	5.0	-1.2	-1.5	2.2	2.2	-2.2	-2.1	2.1	-2.1	-2.1
Locomotion distance, session 8	0.4	0.6	0.9	-0.7	-0.7	0.8	0.9	-0.8	-0.9	0.7	-0.7	-0.7
Degree of sensitization distance	0.2	0.2	0.7	0.8	0.8	-0.3	-0.3	0.2	0.1	-0.0	-0.0	-0.0
Degree of sensitization stereotypy	0.6	0.6	1.0	0.3	0.1	0.8	0.8	-0.9	-0.8	1.0	-1.0	-1.0
Conditioned locomotion	2.2	2.6	3.1	1.1	1.6	-1.8	-1.7	1.7	1.5	-1.6	1.6	1.6
Cocaine response after cond. corrected	1.9	2.9	3.9	1.7	2.0	-1.9	-1.9	1.8	1.2	-1.5	1.6	1.6
Cocaine response after cond. not corrected	2.4	3.5	4.4	1.7	2.0	-2.1	-2.1	2.0	1.4	-1.8	1.8	1.8
Cocaine response before conditioning	0.2	0.3	0.9	-0.8	-0.9	0.5	0.5	-0.5	0.0	0.3	-0.3	-0.3
Saline control response	0.8	1.0	1.3	1.0	1.1	-1.1	-1.1	1.0	1.1	-0.9	0.9	0.9
Bone: connectivity density	1.4	2.2	3.9	-0.1	-0.7	1.5	1.5	-1.6	-2.0	1.7	-1.6	-1.6
Bone: cortical apparent density	0.2	0.4	1.6	1.3	1.1	-0.4	-0.5	0.3	0.1	-0.0	0.1	0.1
Bone: cortical area	1.1	1.7	2.7	0.8	0.1	1.2	1.1	-1.4	-1.6	1.7	-1.6	-1.6
Bone: cortical porosity	0.4	0.4	0.9	-0.0	-0.4	0.7	0.6	-0.7	-0.9	0.7	-0.7	-0.7
Bone: cortical porosity	0.9	1.0	1.7	0.2	-0.4	1.0	0.9	-1.0	-1.3	1.1	-1.2	-1.2
Bone: cortical thickness	0.4	0.7	2.1	1.5	0.9	0.4	0.3	-0.6	-0.8	0.9	-0.8	-0.8
Bone: cortical thickness	0.7	0.9	1.3	1.0	1.1	-1.0	-1.0	0.9	0.8	-0.7	0.9	0.9
Bone: cortical tissue density	0.2	0.2	1.1	1.1	0.9	-0.3	-0.4	0.2	0.1	-0.0	0.1	0.1
Condit. Reinf. active minus inactive responses	0.8	0.9	2.7	-1.6	-1.6	0.9	0.9	-0.7	-0.8	0.4	-0.4	-0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	-0.6	-0.5	-0.2	-0.3	0.3	0.3	-0.5	0.4	0.4
Condit. Reinf. active responses	2.1	2.7	4.8	-2.1	-2.2	1.7	1.7	-1.6	-1.6	1.3	-1.2	-1.2
Condit. Reinf. inactive responses	2.1	2.7	3.4	-1.5	-1.6	1.8	1.8	-1.7	-1.7	1.6	-1.5	-1.5
Incentive salience index mean	1.4	1.7	2.2	-1.4	-1.5	1.4	1.4	-1.3	-1.5	1.1	-1.1	-1.1
Condit. Reinf. lever presses	2.0	3.0	4.8	-0.6	-0.9	1.8	1.9	-1.9	-2.2	1.9	-1.9	-1.9
Condit. Reinf. active minus inactive responses	0.6	0.9	3.2	-1.8	-1.4	-0.1	-0.2	0.4	0.8	-0.8	0.7	0.7
Condit. Reinf. active-inactive response ratio	1.1	1.8	2.8	-0.7	-0.1	-1.2	-1.2	1.4	1.5	-1.7	1.6	1.6
Condit. Reinf. active responses	0.5	0.8	3.0	-1.7	-1.7	0.6	0.6	-0.4	-0.1	0.1	-0.1	-0.1
Condit. Reinf. inactive responses	0.6	0.9	1.3	-0.8	-1.2	1.0	1.0	-1.0	-0.8	0.8	-0.9	-0.9
Condit. Reinf. lever presses	0.7	1.0	4.0	-2.0	-1.8	0.2	0.2	0.0	1.0	-0.4	0.5	0.5
Condit. Reinf. lever reinforcers received	0.4	0.5	2.2	-1.5	-1.4	0.2	0.2	-0.0	0.3	-0.3	0.2	0.2
Conditioned reinforcement - actives	0.0	0.1	0.4	-0.2	-0.5	0.0	-0.1	0.0	-0.6	-0.1	0.0	0.0
Conditioned reinforcement - inactives	0.3	0.8	1.2	0.4	0.3	-1.0	-1.1	1.0	0.4	-1.0	1.0	1.0
Conditioned locomotion	1.4	2.1	6.7	-2.1	-2.6	1.4	1.2	-1.2	-1.1	0.8	-0.8	-0.8
Patch foraging indifference point 0 sec	0.4	1.2	6.1	2.5	1.9	-0.6	-0.6	0.3	-0.2	0.2	-0.2	-0.2
Patch foraging indifference point AUC	0.1	0.2	1.0	-1.0	-0.8	0.2	0.2	-0.1	-0.0	-0.1	0.1	0.1
Delay disc. indifference point, 0s delay	2.0	2.2	3.7	1.3	0.9	1.1	1.1	-1.3	-1.8	1.7	-1.9	-1.9
Delay disc. indifference point, 16s delay	0.1	0.2	0.5	-0.4	-0.3	0.4	0.4	-0.4	0.0	0.3	-0.7	-0.7
Delay disc. indifference point, 2s delay	0.2	0.3	0.6	0.6	0.6	0.5	0.6	-0.6	-0.2	0.8	-0.2	-0.2
Delay disc. indifference point, 24s delay	0.1	0.2	0.7	0.7	0.8	-0.2	-0.1	0.1	0.1	0.0	-0.3	-0.3
Delay disc. indifference point, 4s delay	1.0	1.1	1.5	-0.5	-0.7	1.2	1.2	-1.2	-1.0	1.2	-1.0	-1.0
Delay disc. indifference point, 8s delay	0.2	0.4	0.7	0.5	0.8	-0.8	-0.7	0.8	0.4	-0.7	0.3	0.3
Indifference point function ln k	0.0	0.0	0.1	0.3	0.1	-0.2	-0.3	0.2	0.3	-0.2	0.1	0.1
Indifference point function log k	0.0	0.0	0.1	0.3	0.1	-0.2	-0.3	0.2	0.3	-0.2	0.1	0.1
Patch foraging total patch changes 0 sec	0.4	1.0	5.3	2.3	1.8	-0.6	-0.6	0.3	-0.1	0.2	-0.1	-0.1
Patch foraging total patch changes 12 sec	0.9	1.2	2.8	1.7	1.6	-1.2	-1.2	1.0	0.7	-0.7	0.7	0.7
Patch foraging total patch changes 18 sec	0.0	0.0	0.0	0.2	0.2	0.1	0.1	-0.1	-0.1	0.2	-0.2	-0.2
Patch foraging total patch changes 24 sec	0.1	0.2	0.7	0.8	0.7	0.1	0.2	-0.3	0.1	0.4	-0.4	-0.4
Patch foraging total patch changes 6 sec	0.3	0.5	2.7	1.7	1.2	-0.3	-0.4	0.1	-0.4	0.2	-0.2	-0.2
Patch foraging time to switch 0 sec	0.2	0.6	1.1	0.6	0.2	0.6	0.6	-0.7	-1.1	0.9	-1.0	-1.0
Patch foraging water rate 0 sec	0.4	1.6	2.0	0.9	1.2	-1.4	-1.4	1.4	1.3	-1.3	1.3	1.3
Patch foraging water rate 12 sec	0.5	1.9	2.4	1.1	1.3	-1.5	-1.5	1.5	1.5	-1.4	1.4	1.4
Patch foraging water rate 18 sec	2.2	4.8	8.4	0.2	0.9	-2.3	-2.3	2.4	2.9	-2.5	2.5	2.5
Patch foraging water rate 24 sec	5.8	8.3	9.8	1.6	2.4	-3.1	-3.1	3.1	3.0	-3.0	3.1	3.1
Patch foraging water rate 6 sec	1.5	2.3	3.9	-0.7	-0.2	-1.3	-1.4	1.5	2.0	-1.8	1.8	1.8
Seeking ratio, delayed vs. immediate footshock	0.9	1.3	3.2	-1.5	-1.8	1.3	1.2	-1.1	0.2	0.9	-0.8	-0.8
Distance traveled before self-admin	0.2	0.5	2.0	-1.4	-1.2	0.7	0.7	-0.5	0.0	0.3	-0.2	-0.2
Distance traveled after self-admin	0.0	0.0	0.0	-0.0	0.1	-0.0	0.0	-0.0	0.2	0.0	-0.0	-0.0
Extensor digitorum longus weight	2.8	11.2	24.4	4.9	4.9	-3.4	-3.4	3.0	2.1	-2.2	2.2	2.2
Bone: elastic displacement	0.0	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	-0.0	0.1	-0.1	-0.1
Bone: elastic work	0.2	0.3	1.1	1.0	0.6	0.2	0.2	-0.4	-0.4	0.6	-0.5	-0.5
Bone: endosteal estimation	0.2	0.4	0.7	0.9	0.4	0.4	0.4	-0.5	-0.8	0.8	-0.7	-0.7
Bone: endosteal perimeter	0.8	1.9	2.3	-1.0	-1.4	1.5	1.5	-1.5	-1.4	1.4	-1.3	-1.3
Epididymis fat weight	0.2	1.0	1.5	-0.3	0.3	-1.0	-1.0	1.1	1.2	-1.2	1.1	1.1
Delta time in closed arm before/after self-admin	5.1	4.8	7.8	1.2	1.5	-2.3	-2.4	2.3	2.8	-2.3	2.2	2.2
Delta time in open arm before/after self-admin	0.4	0.4	1.9	1.1	1.4	-0.5	-0.5	0.4	-0.1	-0.2	0.2	0.2
Diff in mean of infusions in LGA sessions	0.4	0.6	2.8	-1.7	-1.5	0.5	0.5	-0.3	-0.1	0.0	-0.0	-0.0
Delay discount exponential model param	0.0	0.0	0.1	-0.2	-0.3	-0.1	-0.2	0.1	-0.0	-0.2	0.3	0.3
Extinction: sum of active levers before priming	0.4	0.6	1.7	-1.3	-0.9	-0.3	-0.3	0.5	0.7	-0.8	0.8	0.8
Active lever presses in extinction session 6	0.3	0.3	0.6	-0.5	-0.5	0.5	0.5	-0.5	-0.8	0.4	-0.4	-0.4
Bone: final force	1.0	1.7	3.9	2.0	1.2	0.7	0.6	-1.0	-1.5	1.5	-1.3	-1.3
Bone: final moment	1.0	1.6	3.9	2.0	1.2	0.7	0.6	-1.0	-1.4	1.4	-1.3	-1.3
Food consumed during 24 hour testing period	0.1	0.1	0.5	0.7	0.7	-0.3	-0.3	0.2	0.2	-0.0	0.1	0.1
Glucose	0.6	1.0	3.5	1.7	1.9	-0.9	-0.8	0.7	0.4	-0.4	0.4	0.4
Heart weight	0.2	0.3	0.5	-0.6	-0.3	-0.4	-0.4	0.5	0.7	-0.7	0.7	0.7
Delay discount hyperbolic model param	0.1	0.1	0.3	-0.5	-0.5	-0.2	-0.3	0.3	0.1	-0.4	0.4	0.4
Intermittent access intake day 1-15 change	0.1	0.5	1.2	-0.9	-0.8	-0.4	-0.5	0.6	1.1	-0.8	0.7	0.7
Intermittent access intake escalation	0.1	0.6	1.3	-0.9	-0.7	-0.5	-0.5	0.6	1.1	-0.9	0.7	0.7
Intermittent access intake escalation 2	0.2	0.3	1.0	-1.0	-0.8	-0.1	-0.1	0.2	0.8	-0.5	0.4	0.4
Intermitt. access day 1 inactive lever presses	0.1	1.5	2.6	-0.6	-0.0	-1.2	-1.2	1.4	1.1	-1.6	1.5	1.5
Intermitt. access day 15 inactive lever presses	0.0	0.2	1.1	-1.1	-0.7	0.1	0.1	0.1	-0.1	-0.3	0.1	0.1
Intermitt. access escalation Index	0.3	0.9	1.6	0.1	-0.2	0.9	0.9	-1.0	-0.7	1.1	-1.3	-1.3
Intermittent access day 1 total infusions	0.0	0.1	0.2	0.4	0.2	-0.4	-0.4	0.3	0.0	-0.3	0.1	0.1
Intermittent access day 15 total infusions	0.0	0.0	0.2	-0.2	-0.5	0.1	-0.0	-0.0	0.0	-0.0	-0.2	-0.2
Intermittent access terminal intake (last 3 days)	0.2	0.4	0.7	-0.4	-0.8	0.6	0.6	-0.6	-0.6	0.6	-0.7	-0.7
Intermittent access total infusions	0.0	0.1	0.2	0.1	-0.2	0.1	0.0	-0.1	-0.5	0.2	-0.3	-0.3
Intermittent access day 1 locomotion	0.2	0.5	0.7	0.2	0.3	-0.8	-0.8	0.8	0.4	-0.8	0.7	0.7
Intermittent access day 15 total locomotion	0.1	0.4	0.6	-0.7	-0.8	-0.4	-0.5	0.5	0.4	-0.7	0.7	0.7
Intermittent access total locomotion	0.1	0.1	0.2	-0.4	-0.5	-0.2	-0.3	0.3	0.2	-0.4	0.4	0.4
Intermittent access standard deviation	0.2	1.0	2.9	-1.3	-1.7	0.9	0.8	-0.8	-0.8	0.6	-0.7	-0.7
Left kidney weight	0.0	0.1	0.2	0.1	0.4	-0.4	-0.4	0.4	0.4	-0.4	0.4	0.4
Right kidney weight	0.0	0.2	0.5	-0.7	-0.4	-0.2	-0.2	0.3	0.5	-0.5	0.4	0.4
Cocaine induced anxiety	0.9	2.4	3.3	-1.5	-1.8	1.8	1.8	-1.7	-0.7	1.5	-1.5	-1.5
Post-drug Anxiety	2.6	3.0	4.3	-1.0	-1.5	2.1	2.0	-2.1	-0.4	2.0	-1.8	-1.8
Baseline Anxiety	0.0	0.0	0.2	0.1	0.1	-0.0	-0.0	0.0	0.4	0.0	0.0	0.0
Tail length	0.6	3.3	14.8	-3.8	-3.4	1.2	1.2	-0.8	-0.0	0.0	0.0	0.0
Length with tail	0.3	1.4	6.5	-2.5	-2.0	0.2	0.2	0.1	0.6	-0.6	0.7	0.7
Length without tail	0.1	0.8	1.2	0.9	1.1	-1.0	-1.0	0.9	0.8	-0.8	0.7	0.7
Times rat made contact with spout	1.0	1.1	2.2	1.3	1.5	-1.2	-1.2	1.1	0.5	-0.9	0.7	0.7
Lifetime Intake	0.1	0.1	0.3	0.6	0.1	0.0	-0.1	-0.1	-0.5	0.2	-0.3	-0.3
Liver weight, left	0.2	0.3	1.1	0.9	1.0	-0.6	-0.5	0.5	0.3	-0.3	0.3	0.3
Liver weight, right	0.1	0.1	0.2	-0.2	0.1	-0.4	-0.3	0.4	0.5	-0.5	0.4	0.4
Locomotor activity	2.0	3.1	5.6	-2.3	-2.4	1.9	1.9	-1.7	-1.1	1.3	-1.3	-1.3
Locomotor testing distance	0.7	1.8	3.2	-1.7	-1.8	1.5	1.5	-1.3	-0.7	1.1	-1.1	-1.1
Locomotor testing rearing	0.0	0.1	0.2	-0.0	0.1	-0.3	-0.3	0.4	0.5	-0.4	0.3	0.3
Locomotion in novel chamber	0.0	0.0	0.0	0.2	-0.1	-0.0	-0.1	0.0	0.2	0.0	-0.1	-0.1
Locomotion in novel chamber post-restriction	0.5	1.6	6.4	-2.5	-2.2	1.1	1.1	-0.8	0.6	0.3	-0.2	-0.2
Fecal boli incidents, locomotor time 1	0.6	1.5	2.0	1.1	1.4	-1.3	-1.2	1.2	1.2	-1.1	1.3	1.3
Change in fecal boli incidents, locomotor task	2.0	2.1	2.5	-0.9	-1.2	1.6	1.6	-1.6	-1.5	1.5	-1.6	-1.6
Time >=10cm from walls, locomotor time 1	0.8	1.0	2.1	0.6	0.2	0.8	0.8	-1.0	-1.5	1.2	-1.2	-1.2
Bouts of movement, locomotor time 1	0.1	0.2	0.9	-0.9	-0.8	0.1	0.1	-0.0	-0.3	-0.2	-0.1	-0.1
Total resting periods, locomotor time 1	0.4	0.4	1.8	-1.3	-1.2	0.5	0.5	-0.3	-0.3	0.0	-0.2	-0.2
Rest time, locomotor task time 1	0.4	0.6	0.8	-0.8	-0.9	0.9	0.9	-0.8	-0.7	0.7	-0.7	-0.7
Distance moved, locomotor task time 1	0.4	1.1	2.0	0.8	0.3	0.8	0.8	-1.0	-1.4	1.2	-1.2	-1.2
Vertical activity count, locomotor time 1	0.1	0.4	1.4	1.2	1.0	-0.6	-0.7	0.5	0.1	-0.3	0.1	0.1
Time >=10cm from walls, locomotor time 2	0.3	1.0	1.3	1.1	1.1	-1.0	-1.0	0.9	1.0	-0.8	0.9	0.9
Bouts of movement, locomotor time 2	0.5	1.5	3.3	-0.5	-0.8	1.1	1.1	-1.1	-1.8	1.1	-1.5	-1.5
Total resting periods, locomotor time 2	0.5	2.0	4.2	-0.5	-0.8	1.3	1.3	-1.3	-2.0	1.3	-1.7	-1.7
Rest time, locomotor task time 2	0.4	0.8	1.0	-0.3	-0.5	1.0	1.0	-1.0	-1.0	1.0	-0.9	-0.9
Distance moved, locomotor task time 2	0.3	0.5	0.8	0.2	0.3	-0.8	-0.8	0.8	0.5	-0.9	0.7	0.7
Vertical activity count, locomotor time 2	0.8	2.0	2.8	1.2	1.5	-1.7	-1.7	1.6	1.1	-1.5	1.1	1.1
Light reinforcement 1	0.6	2.8	7.9	-2.8	-2.8	1.6	1.6	-1.3	-0.9	0.8	-0.7	-0.7
Light reinforcement 2	0.2	0.6	1.9	-1.3	-1.4	0.7	0.6	-0.5	-0.4	0.3	-0.2	-0.2
Bone: marrow area	0.1	0.4	0.6	0.8	0.3	0.4	0.4	-0.5	-0.7	0.7	-0.7	-0.7
Bone: maximum diameter	1.4	2.9	3.5	-1.1	-1.6	1.9	1.8	-1.8	-1.6	1.8	-1.7	-1.7
Bone: maximum force	0.7	1.4	4.4	2.1	1.4	0.4	0.4	-0.7	-1.1	1.2	-1.1	-1.1
Bone: maximum moment	0.7	1.3	4.4	2.1	1.4	0.4	0.3	-0.7	-1.1	1.2	-1.1	-1.1
Mean time between licks in bursts	0.1	0.3	1.5	-1.2	-1.2	0.3	0.2	-0.1	0.3	-0.1	0.1	0.1
Mean num. licks in bursts	0.2	0.5	0.9	-0.9	-1.0	0.7	0.7	-0.6	-0.5	0.4	-0.6	-0.6
Cd content in liver	0.2	0.2	0.7	-0.7	-0.8	0.4	0.4	-0.3	-0.1	0.2	-0.2	-0.2
Co content in liver	0.7	0.8	3.5	-1.9	-1.7	0.2	0.2	0.0	0.4	-0.4	0.4	0.4
Cu content in liver	0.9	1.0	2.0	0.4	-0.1	1.0	0.9	-1.1	-1.4	1.2	-1.2	-1.2
Fe content in liver	0.2	0.2	0.3	0.5	0.5	-0.6	-0.6	0.5	0.1	-0.5	0.5	0.5
K content in liver	1.3	1.2	1.9	-1.0	-1.4	1.2	1.2	-1.2	-1.0	1.0	-1.0	-1.0
Mg content in liver	0.9	1.0	1.9	-1.2	-1.4	1.1	1.1	-1.0	-0.8	0.8	-0.8	-0.8
Mn content in liver	5.3	6.0	7.5	-1.5	-2.1	2.7	2.7	-2.6	-2.7	2.5	-2.5	-2.5
Na content in liver	0.4	0.4	0.8	0.3	0.1	0.6	0.6	-0.7	-0.9	0.8	-0.7	-0.7
Rb content in liver	1.2	1.4	2.2	0.2	-0.4	1.2	1.1	-1.3	-1.2	1.4	-1.5	-1.5
Se content in liver	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1	-0.0	-0.4	0.0	-0.0	-0.0
Sr content in liver	0.4	0.3	0.5	-0.4	-0.4	-0.4	-0.5	0.5	0.7	-0.7	0.7	0.7
Zn content in liver	1.6	1.8	3.0	-1.7	-1.2	-0.8	-0.8	1.1	1.4	-1.6	1.6	1.6
Bone: minimum diameter	0.5	1.1	1.6	0.3	-0.2	1.0	1.0	-1.1	-1.2	1.3	-1.2	-1.2
Time in familiar zone, hab. session 1	0.9	1.0	4.8	-2.2	-1.8	0.4	0.4	-0.1	0.3	-0.3	0.4	0.4
Time in novel zone, hab. session 1	1.1	1.2	3.1	1.8	1.2	0.5	0.4	-0.7	-1.2	1.2	-1.2	-1.2
Total zone transitions, hab. session 1	1.7	2.4	3.0	-0.8	-1.0	1.7	1.7	-1.7	-1.7	1.7	-1.6	-1.6
Total locomotion distance, hab. session 1	4.3	6.1	7.4	-1.7	-2.2	2.7	2.7	-2.7	-2.7	2.5	-2.4	-2.4
Locomotion velocity, hab. session 1	3.2	4.5	5.5	-1.8	-2.1	2.4	2.4	-2.3	-2.2	2.1	-2.0	-2.0
Time in familiar zone, hab. session 2	1.2	1.4	5.5	-2.3	-1.9	0.0	-0.0	0.3	0.9	-0.8	0.9	0.9
Time in novel zone, hab. session 2	1.4	1.6	5.6	2.4	1.9	0.2	0.2	-0.5	-1.1	1.0	-1.1	-1.1
Total zone transitions, hab. session 2	2.0	2.6	4.3	0.6	0.1	1.5	1.5	-1.7	-2.1	1.9	-1.9	-1.9
Total locomotion distance, hab. session 2	1.4	1.8	2.6	-0.7	-0.8	1.4	1.5	-1.5	-1.6	1.4	-1.4	-1.4
Locomotion velocity, hab. session 2	2.0	2.7	3.9	-0.7	-1.0	1.8	1.8	-1.8	-2.0	1.8	-1.7	-1.7
Novel to familiar place preference ratio	1.0	1.3	2.8	1.7	1.2	0.6	0.6	-0.9	-1.2	1.3	-1.2	-1.2
Novelty place preference	0.8	1.1	1.7	1.3	0.8	0.7	0.7	-0.9	-1.2	1.2	-1.2	-1.2
Time in novel zone, NPP test	0.8	1.0	2.4	1.5	1.1	0.5	0.5	-0.7	-1.1	1.1	-1.0	-1.0
Total zone transitions, NPP test	0.5	0.8	1.4	0.7	0.5	0.7	0.7	-0.8	-1.2	1.0	-1.0	-1.0
Total locomotion distance, NPP test	0.9	1.3	2.5	0.1	-0.1	1.1	1.2	-1.2	-1.6	1.4	-1.3	-1.3
Locomotion velocity, NPP test	0.9	1.3	2.4	-0.2	-0.4	1.2	1.2	-1.3	-1.5	1.3	-1.3	-1.3
Intraocular pressure	1.1	1.8	3.4	-0.3	0.4	-1.3	-1.2	1.4	1.8	-1.6	1.6	1.6
Delta distance traveled before/after self-admin	0.3	0.3	0.8	0.9	0.8	-0.5	-0.5	0.4	0.4	-0.3	0.2	0.2
Delta ambulatory time before/after self-admin	0.1	0.2	0.8	0.9	0.7	-0.0	0.0	-0.1	-0.2	0.3	-0.4	-0.4
Parametrial fat weight	0.1	0.2	0.9	1.0	0.7	-0.1	-0.1	-0.0	-0.3	0.3	-0.2	-0.2
Pavlov. Cond. lever latency	1.5	1.9	2.7	0.3	0.6	-1.5	-1.5	1.5	1.7	-1.6	1.6	1.6
Pavlov. Cond. magazine entry latency	0.4	0.6	2.1	-1.5	-1.3	0.6	0.6	-0.5	-0.4	0.2	-0.2	-0.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.4	0.3	-0.0	-0.0	-0.0	-0.3	0.1	-0.0	-0.0
Pavlov. Cond. index score	0.7	0.9	1.1	-0.8	-0.8	1.0	1.1	-1.0	-1.0	0.9	-0.8	-0.8
Pavlov. Cond. latency score	1.2	1.6	2.0	-0.9	-1.0	1.4	1.4	-1.4	-1.4	1.3	-1.2	-1.2
Pavlov. Cond. lever contacts	1.3	1.5	2.5	-0.1	-0.3	1.3	1.3	-1.3	-1.6	1.4	-1.4	-1.4
Pavlov. Cond. magazine entry number	0.1	0.2	0.9	0.9	0.7	-0.3	-0.3	0.2	0.1	0.0	-0.0	-0.0
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.1	-0.1	0.1	-0.8	-0.8	0.9	1.1	-1.0	0.9	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.0	-0.9	-0.9	1.0	1.0	-0.9	-1.0	0.8	-0.8	-0.8
Pavlov. Cond. response bias	0.1	0.2	0.7	-0.8	-0.6	0.4	0.4	-0.3	-0.3	0.2	-0.1	-0.1
Pavlov. Cond. lever latency	0.5	0.7	2.5	1.6	1.5	-0.7	-0.7	0.5	-0.5	-0.2	0.2	0.2
Pavlov. Cond. magazine entry latency	0.7	1.0	3.3	-1.8	-1.7	0.9	0.9	-0.7	-0.2	0.4	-0.3	-0.3
Pavlov. Cond. change in total contacts	0.1	0.3	1.3	-1.1	-1.1	0.2	0.2	-0.1	0.4	-0.1	0.1	0.1
Pavlov. Cond. index score	0.5	0.8	3.1	-1.8	-1.6	0.6	0.6	-0.4	0.4	0.1	-0.1	-0.1
Pavlov. Cond. latency score	0.6	1.0	3.4	-1.8	-1.7	0.9	0.9	-0.7	0.1	0.3	-0.3	-0.3
Pavlov. Cond. lever contacts	0.4	0.6	2.3	-1.5	-1.4	0.4	0.4	-0.2	0.8	-0.1	0.1	0.1
Pavlov. Cond. magazine entry number	0.9	1.1	3.5	1.9	1.8	-1.0	-1.0	0.8	0.1	-0.5	0.4	0.4
Pavlov. Cond. intertrial magazine entries	0.4	1.0	1.6	1.2	1.3	-1.1	-1.1	1.0	0.9	-0.8	0.6	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.0	3.6	-1.9	-1.8	0.9	0.8	-0.7	0.2	0.3	-0.3	-0.3
Pavlov. Cond. response bias	0.6	0.9	3.6	-1.9	-1.7	0.4	0.4	-0.2	0.9	-0.2	0.2	0.2
Time in closed arm before self-admin	0.4	0.7	1.2	0.2	-0.2	0.9	0.9	-1.0	-0.8	1.1	-1.1	-1.1
Time in closed arm after self-admin	0.4	0.5	2.3	0.5	0.2	-0.5	-0.6	0.5	1.5	-0.4	0.4	0.4
Time in open arm before self-admin	0.1	0.1	0.3	-0.2	-0.4	-0.1	-0.1	0.1	-0.5	-0.2	0.1	0.1
Time in open arm after self-admin	1.0	1.1	3.2	1.5	1.8	-1.1	-1.0	0.9	-0.4	-0.7	0.7	0.7
Bone: periosteal estimation	0.8	1.8	2.9	1.0	0.2	1.2	1.1	-1.4	-1.6	1.7	-1.6	-1.6
Bone: periosteal perimeter	1.1	2.2	3.0	-0.3	-0.9	1.6	1.6	-1.7	-1.7	1.7	-1.6	-1.6
Bone: post-yield work	0.1	0.1	0.7	0.8	0.6	-0.2	-0.2	0.1	0.1	0.1	-0.1	-0.1
Progressive ratio test 1 active lever presses	0.1	0.1	0.4	0.6	0.4	-0.4	-0.4	0.4	-0.0	-0.3	0.1	0.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.4	0.6	0.4	-0.4	-0.5	0.4	-0.0	-0.3	0.1	0.1
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.7	-0.7	-0.9	0.2	0.1	-0.1	-0.2	0.0	-0.1	-0.1
Progressive ratio test 2 active lever presses	0.1	0.1	0.4	-0.3	-0.5	0.2	0.1	-0.1	-0.6	0.1	-0.1	-0.1
Progressive ratio test 2 breakpoint	0.1	0.1	0.5	-0.5	-0.6	0.2	0.2	-0.2	-0.7	0.1	-0.2	-0.2
Progressive ratio test 2 inactive lever presses	0.1	0.3	1.0	0.1	-0.3	0.5	0.4	-0.5	-1.0	0.6	-0.7	-0.7
Incentive Sensitization - Responses	0.0	0.1	0.5	-0.7	-0.5	0.2	0.2	-0.1	-0.5	-0.1	-0.0	-0.0
Incentive Sensitization - Breakpoint	0.1	0.2	0.7	-0.8	-0.7	0.4	0.4	-0.3	-0.7	0.1	-0.2	-0.2
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.5	-0.3	-0.2	-0.1	-0.1	0.1	0.7	-0.2	0.2	0.2
Progressive ratio	0.3	0.9	1.7	1.3	1.2	-1.1	-1.1	1.0	-0.2	-0.8	0.7	0.7
Food seeking constrained by brief footshock	0.3	0.4	2.0	-1.4	-0.8	0.4	0.5	-0.3	0.1	0.0	-0.0	-0.0
Seeking ratio, punishment vs. effort	0.4	0.9	3.4	-1.8	-1.4	0.9	1.0	-0.7	0.7	0.4	-0.4	-0.4
Retroperitoneal fat weight	1.5	6.8	11.2	3.2	3.3	-2.8	-2.8	2.6	2.0	-2.1	2.1	2.1
Reaction time number correct	0.6	2.0	2.9	1.3	1.7	-1.5	-1.5	1.5	1.3	-1.3	1.3	1.3
Reaction time mean minus median	0.1	0.7	1.8	-1.4	-1.3	0.8	0.8	-0.7	0.1	0.5	-0.5	-0.5
Reaction time mean minus median AUC	0.5	3.2	4.3	-1.5	-1.7	2.0	2.1	-2.0	-1.3	1.8	-1.8	-1.8
Reaction time num false alarms	0.2	0.4	1.0	1.0	0.9	-0.7	-0.7	0.6	-0.0	-0.4	0.3	0.3
Reaction time num false alarms AUC	0.3	0.7	1.1	1.0	1.0	-0.9	-0.9	0.8	0.4	-0.7	0.6	0.6
Reaction time trials correct on left	0.6	2.0	2.9	1.3	1.7	-1.5	-1.5	1.5	1.3	-1.3	1.3	1.3
Reaction time trials on left	0.5	1.8	2.7	1.2	1.7	-1.4	-1.4	1.4	1.2	-1.2	1.2	1.2
Reaction time mean	0.9	1.9	2.6	-1.3	-1.4	1.6	1.6	-1.5	-0.7	1.3	-1.4	-1.4
Reaction time mean AUC	0.6	1.4	2.0	-0.9	-1.1	1.4	1.4	-1.3	-0.6	1.2	-1.3	-1.3
Median of all reaction times	1.0	1.5	2.1	-1.0	-1.1	1.4	1.5	-1.4	-0.8	1.3	-1.3	-1.3
Reaction time omissions	0.4	0.6	0.9	-0.2	-0.6	0.9	0.8	-0.9	-0.3	0.9	-0.9	-0.9
Reaction time false alarm rate	0.0	0.1	0.2	0.4	0.2	0.1	0.1	-0.1	-0.4	0.2	-0.3	-0.3
Reaction time premature initiation rate	0.4	0.6	1.5	-1.2	-0.8	-0.4	-0.4	0.6	0.7	-0.9	0.9	0.9
Reaction time premature initiations	0.6	1.8	2.8	-0.6	0.1	-1.3	-1.3	1.5	1.5	-1.7	1.6	1.6
Std. dev. reaction times	0.3	1.2	1.7	-1.1	-1.3	1.2	1.2	-1.1	-0.6	1.0	-1.0	-1.0
Reaction time trials completed	0.5	1.8	2.7	1.2	1.7	-1.4	-1.4	1.4	1.2	-1.2	1.2	1.2
Reaction time trials AUC	0.7	2.4	3.4	1.4	1.9	-1.7	-1.7	1.6	1.4	-1.5	1.4	1.4
Run reversals in cocaine runway, females	2.1	2.4	3.4	-1.8	-1.8	1.6	1.6	-1.5	-1.8	1.2	-1.2	-1.2
Run reversals in cocaine runway, males	1.5	1.7	3.5	-1.7	-1.9	1.5	1.4	-1.3	-0.3	1.1	-0.8	-0.8
Latency to leave start box in cocaine runway	1.2	1.6	2.5	0.2	-0.4	1.3	1.3	-1.4	-1.2	1.5	-1.6	-1.6
Latency to leave start box in cocaine runway, F	2.2	2.7	4.2	0.2	-0.4	1.7	1.8	-1.9	-1.5	2.0	-2.0	-2.0
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	0.1	0.1	-0.5	-0.5	0.5	0.6	-0.5	0.4	0.4
Std. dev. time between licks in bursts	1.1	2.0	2.5	-1.1	-1.5	1.6	1.6	-1.6	-1.1	1.4	-1.5	-1.5
Total sessions with >9 infusions	0.1	0.1	0.1	0.4	-0.3	0.2	0.0	-0.2	0.1	0.3	-0.4	-0.4
Short access day 1 total inactive lever presses	0.1	0.2	0.5	-0.7	-0.5	-0.3	-0.3	0.4	0.5	-0.6	0.5	0.5
Short access day 10 total inactive lever presses	0.3	1.8	2.9	-0.3	0.2	-1.4	-1.4	1.5	1.4	-1.7	1.6	1.6
Short access day 1 total infusions	0.0	0.1	0.1	0.4	-0.3	0.1	-0.1	-0.1	0.1	0.2	-0.3	-0.3
Short access day 10 total infusions	0.0	0.0	0.1	0.3	-0.0	-0.2	-0.2	0.1	-0.1	-0.1	-0.1	-0.1
Short access total infusions	0.1	0.1	0.4	0.7	0.0	0.1	-0.1	-0.1	-0.5	0.3	-0.4	-0.4
Short access day 1 locomotion	0.1	0.2	1.2	-0.9	-1.1	0.1	-0.0	0.1	0.3	-0.3	0.1	0.1
Short access day 10 total locomotion	0.3	1.3	2.8	-1.7	-1.4	-0.6	-0.8	0.9	0.9	-1.3	1.2	1.2
Short access total locomotion	0.2	0.3	0.9	-0.8	-0.9	-0.2	-0.3	0.3	0.5	-0.5	0.4	0.4
One hour access (0.3 mA shock)	0.2	0.3	0.4	0.3	0.4	-0.6	-0.6	0.6	0.1	-0.6	0.6	0.6
Compulsive drug intake	0.0	0.0	0.1	-0.1	-0.1	0.3	0.3	-0.2	0.0	0.2	-0.1	-0.1
One hour access (shock baseline)	0.0	0.1	0.1	-0.3	-0.3	-0.2	-0.2	0.2	-0.3	-0.3	0.1	0.1
Social response proportion	0.6	0.7	1.0	-1.0	-0.7	0.9	0.9	-0.8	-1.0	0.7	-0.7	-0.7
Social responses	4.3	5.6	12.9	-3.6	-3.4	2.4	2.5	-2.1	-1.5	1.5	-1.6	-1.6
Social time	0.7	1.1	2.7	1.4	1.7	-1.1	-1.0	0.9	0.6	-0.7	0.6	0.6
Soleus weight	2.0	5.8	20.8	4.6	4.3	-2.0	-2.0	1.5	1.0	-0.7	0.6	0.6
Bone: stiffness	0.8	1.4	6.0	2.4	1.9	-0.0	-0.1	-0.3	-1.0	0.8	-0.8	-0.8
Tibialis anterior weight	0.5	1.6	5.5	2.4	2.3	-1.1	-1.1	0.8	0.7	-0.4	0.4	0.4
Time to tail flick, vehicle, before self-admin	1.0	1.2	1.9	-1.2	-1.4	1.3	1.2	-1.2	0.5	1.0	-0.9	-0.9
Time to tail flick, vehicle, after self-admin	0.5	1.0	1.6	-0.4	0.1	-1.0	-1.0	1.1	0.8	-1.3	1.2	1.2
Time to tail flick, test, before self-admin	1.8	2.0	2.4	-0.9	-1.4	1.5	1.5	-1.5	-1.5	1.4	-1.4	-1.4
Time to tail flick, test, after self-admin	0.2	0.2	0.4	-0.1	-0.4	0.5	0.5	-0.6	-0.2	0.6	-0.6	-0.6
Delta time to tail flick, vehicle, before/after SA	2.4	2.5	3.5	1.3	1.8	-1.9	-1.8	1.8	0.6	-1.6	1.6	1.6
Delta time to tail flick, test, before/after SA	1.2	1.5	2.9	0.3	0.7	-1.2	-1.2	1.3	1.7	-1.3	1.3	1.3
Tibia length	0.2	0.5	2.5	-1.6	-1.2	0.3	0.3	-0.1	0.0	-0.2	0.2	0.2
Ambulatory time before self-admin	0.0	0.1	0.6	-0.8	-0.6	0.2	0.2	-0.2	0.2	0.0	0.1	0.1
Ambulatory time after self-admin	0.0	0.0	0.0	0.1	0.1	0.1	0.1	-0.1	0.2	0.1	-0.1	-0.1
Bone: tissue strength	1.0	1.1	5.5	2.4	1.8	-0.5	-0.5	0.2	-0.3	0.3	-0.3	-0.3
Total heroin consumption	1.1	1.3	2.9	-1.7	-1.6	1.2	1.2	-1.0	-0.6	0.8	-0.7	-0.7
Bone: trabecular number	1.3	2.5	3.1	-0.9	-1.3	1.8	1.8	-1.8	-1.6	1.7	-1.6	-1.6
Bone: trabecular spacing	3.3	4.8	6.4	0.6	1.2	-2.4	-2.4	2.5	2.4	-2.5	2.4	2.4
Bone: trabecular thickness	6.1	8.4	11.9	-0.0	-1.1	3.0	3.0	-3.2	-3.5	3.4	-3.3	-3.3
Bone: trabecular tissue density	1.9	3.3	7.7	2.8	2.7	-1.9	-1.9	1.6	1.2	-1.2	1.0	1.0
Water consumed over 24 hours	0.3	0.5	0.8	0.9	0.5	0.4	0.4	-0.6	-0.8	0.8	-0.9	-0.9
Number of responses in last shaping day	0.6	0.8	3.1	-1.7	-1.7	0.1	0.0	0.1	0.6	-0.5	0.3	0.3