Hub : Genes

Pycr1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Pycr1 0.05 0.04 1.3e-05 0.04 0.03 0.04 0.04 1.3e-06 2.0e-05 9.4e-07 2.6e-06
2 pVTA isoform ratio NM_001105857.3 0.18 0.12 1.2e-07 0.1 0.07 0.09 0.08 4.7e-08 1.1e-06 2.5e-07 2.8e-07
3 Brain isoform ratio NM_001105857.3 0.18 0.1 1.1e-11 0.12 0.13 0.13 0.12 3.1e-11 9.1e-12 8.2e-12 5.0e-11
4 PL isoform ratio NM_001105857.3 0.18 0.08 0.0e+00 0.18 0.18 0.18 0.19 7.1e-19 7.9e-20 1.5e-19 1.2e-20
5 NAcc isoform ratio XM_008768474.2 0.06 0.04 2.9e-06 0.04 0.04 0.03 0.03 2.5e-06 2.9e-06 6.8e-06 5.8e-06
6 IC isoform ratio NM_001105857.3 0.18 0.11 2.2e-04 0.08 0.09 0.05 0.06 3.6e-04 1.4e-04 4.5e-03 1.3e-03
7 BLA isoform ratio NM_001105857.3 0.13 0.08 4.7e-05 0.09 0.09 0.06 0.08 1.1e-05 2.4e-05 6.3e-04 3.7e-05
8 NAcc isoform ratio NM_001105857.3 0.27 0.12 0.0e+00 0.13 0.14 0.13 0.13 4.0e-19 2.9e-20 3.7e-19 4.2e-19
9 Brain isoform ratio XM_008768473.4 0.04 0.03 7.1e-03 0.02 0.01 0.02 0.01 4.8e-03 2.4e-02 8.7e-03 3.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.30.60.7-0.6-0.8-0.7-0.80.8-0.8-0.9-0.70.8
Area under the delay curve0.50.51.71.30.90.50.7-0.80.40.60.5-0.4
BMI with tail0.61.92.9-1.2-1.6-1.1-1.71.5-1.3-1.3-1.41.2
BMI without tail2.37.210.7-3.3-2.8-2.3-2.92.6-2.4-2.6-2.22.7
Body weight1.04.411.4-3.4-2.1-1.5-2.22.2-1.5-1.9-1.51.7
Weight adjusted by age0.61.02.3-1.5-1.3-0.6-1.30.9-0.6-0.8-0.80.6
Bone surface0.00.10.3-0.5-0.00.0-0.10.2-0.1-0.2-0.00.2
Bone volume0.10.20.4-0.7-0.4-0.3-0.40.5-0.4-0.5-0.40.5
Breakpoint value in progressive ratio session0.40.50.9-0.10.80.60.4-0.61.00.60.9-0.9
Number of licking bursts0.40.60.9-0.3-0.7-0.6-0.71.0-0.8-0.9-0.90.7
Context. condit. distance diff. score3.64.45.2-1.0-2.1-2.2-2.22.3-2.2-2.3-2.22.0
Locomotion velocity, session 14.14.45.21.71.91.92.3-2.32.12.32.1-2.1
Locomotion distance, session 10.30.32.51.6-0.1-0.3-0.0-0.0-0.40.0-0.40.1
Locomotion velocity, session 22.73.16.42.51.61.71.8-1.81.51.81.5-1.5
Locomotion distance, session 20.40.50.70.3-0.8-0.8-0.80.6-0.8-0.8-0.70.8
Locomotion velocity, session 32.12.43.51.91.41.61.5-1.51.41.51.2-1.8
Locomotion distance, session 31.51.65.12.31.11.11.2-1.20.91.20.7-1.3
Stereotopy head waving bouts, day 31.01.11.71.01.31.11.3-1.01.00.91.0-1.1
Stereotopy head waving duration, day 30.30.40.70.80.70.60.8-0.60.50.50.5-0.6
Locomotion velocity, session 70.20.21.21.10.10.30.2-0.10.10.0-0.1-0.4
Locomotion distance, session 70.70.83.01.7-0.8-0.8-0.60.6-0.9-0.7-1.10.4
Stereotopy head waving bouts, day 70.00.10.3-0.5-0.1-0.1-0.10.3-0.1-0.3-0.10.2
Stereotopy head waving duration, day 70.10.10.3-0.5-0.10.0-0.00.3-0.1-0.3-0.20.2
Locomotion velocity, session 80.81.01.30.3-1.0-1.1-1.01.0-1.2-1.1-1.01.1
Locomotion distance, session 85.37.89.3-0.9-2.9-2.9-3.02.9-3.0-2.9-3.02.8
Degree of sensitization distance2.02.12.5-1.1-1.5-1.5-1.61.5-1.4-1.6-1.31.4
Degree of sensitization stereotypy0.30.30.5-0.7-0.5-0.5-0.50.6-0.6-0.6-0.50.6
Conditioned locomotion4.45.17.0-2.6-2.1-2.2-2.42.3-2.1-2.3-1.92.3
Cocaine response after cond. corrected0.50.60.90.30.80.70.6-0.90.80.90.9-0.8
Cocaine response after cond. not corrected0.70.91.20.81.00.90.8-1.10.91.01.0-0.8
Cocaine response before conditioning0.10.10.90.9-0.1-0.10.00.2-0.3-0.2-0.40.3
Saline control response1.72.24.8-2.2-1.3-1.3-1.41.5-1.3-1.5-1.11.6
Bone: connectivity density0.50.81.2-0.2-0.8-0.8-0.81.0-1.0-1.1-0.91.0
Bone: cortical apparent density1.31.85.02.21.31.11.2-1.31.01.30.8-1.3
Bone: cortical area1.11.78.6-2.9-0.9-0.6-1.11.1-0.6-1.1-0.61.0
Bone: cortical porosity2.62.83.6-0.31.91.71.5-1.71.91.71.9-1.8
Bone: cortical porosity1.61.72.3-0.71.51.31.1-1.31.51.31.5-1.4
Bone: cortical thickness0.50.87.0-2.6-0.20.1-0.30.30.2-0.30.20.2
Bone: cortical thickness0.10.21.2-1.1-0.2-0.1-0.30.10.0-0.10.00.1
Bone: cortical tissue density1.52.15.62.41.41.21.4-1.41.11.40.9-1.4
Condit. Reinf. active minus inactive responses1.41.63.6-1.9-1.2-1.0-1.31.3-1.0-1.3-0.81.2
Condit. Reinf. active-inactive response ratio0.60.61.2-1.1-0.8-0.6-0.80.7-0.6-0.7-0.60.7
Condit. Reinf. active responses2.83.57.6-2.8-1.7-1.6-1.91.9-1.5-1.9-1.21.9
Condit. Reinf. inactive responses0.81.02.4-1.5-0.7-0.9-1.01.0-0.8-1.1-0.51.1
Incentive salience index mean1.41.73.0-1.7-1.3-1.0-1.31.3-1.1-1.4-1.01.3
Condit. Reinf. lever presses0.50.71.0-0.2-0.9-0.7-0.81.0-0.9-1.0-1.00.8
Condit. Reinf. active minus inactive responses0.50.61.2-1.1-0.6-0.8-0.70.8-0.7-0.9-0.41.0
Condit. Reinf. active-inactive response ratio0.30.42.6-1.6-0.2-0.1-0.30.3-0.1-0.40.20.5
Condit. Reinf. active responses0.40.50.8-0.6-0.5-0.9-0.70.7-0.8-0.9-0.50.9
Condit. Reinf. inactive responses0.10.10.60.8-0.1-0.5-0.20.2-0.4-0.2-0.40.2
Condit. Reinf. lever presses0.91.21.9-0.8-1.0-1.4-1.21.1-1.2-1.2-1.01.1
Condit. Reinf. lever reinforcers received0.70.91.4-0.7-0.7-1.2-1.10.9-1.1-1.1-0.81.1
Conditioned reinforcement - actives0.00.10.2-0.0-0.2-0.3-0.10.3-0.3-0.4-0.40.2
Conditioned reinforcement - inactives0.10.20.5-0.6-0.70.1-0.60.2-0.3-0.3-0.20.6
Conditioned locomotion0.10.10.2-0.4-0.3-0.4-0.20.2-0.4-0.4-0.40.4
Patch foraging indifference point 0 sec0.00.00.1-0.2-0.3-0.2-0.20.1-0.2-0.2-0.20.1
Patch foraging indifference point AUC0.10.20.4-0.4-0.2-0.6-0.40.5-0.5-0.6-0.20.3
Delay disc. indifference point, 0s delay0.00.00.10.1-0.2-0.1-0.20.1-0.2-0.1-0.3-0.0
Delay disc. indifference point, 16s delay0.40.40.70.9-0.5-0.8-0.40.2-0.9-0.5-0.90.5
Delay disc. indifference point, 2s delay0.60.61.21.00.81.10.7-0.90.60.80.7-0.6
Delay disc. indifference point, 24s delay4.14.68.12.82.22.12.2-2.21.82.01.7-2.0
Delay disc. indifference point, 4s delay0.30.31.10.51.00.40.5-0.70.40.50.6-0.2
Delay disc. indifference point, 8s delay1.11.31.81.21.41.31.1-1.21.01.01.2-0.8
Indifference point function ln k0.10.21.21.10.20.20.3-0.40.10.4-0.1-0.3
Indifference point function log k0.10.21.21.10.20.20.3-0.40.10.4-0.1-0.3
Patch foraging total patch changes 0 sec0.10.10.2-0.4-0.5-0.4-0.40.2-0.3-0.4-0.30.3
Patch foraging total patch changes 12 sec0.10.10.3-0.30.40.10.3-0.30.30.20.5-0.3
Patch foraging total patch changes 18 sec0.50.81.7-0.2-1.0-1.3-0.90.8-1.0-0.9-0.90.6
Patch foraging total patch changes 24 sec0.40.61.1-1.0-1.1-0.8-0.80.6-0.7-0.7-0.70.7
Patch foraging total patch changes 6 sec0.10.10.5-0.70.30.10.1-0.10.2-0.00.3-0.1
Patch foraging time to switch 0 sec0.20.51.01.00.80.70.7-0.60.50.80.4-0.7
Patch foraging water rate 0 sec1.43.04.9-2.2-2.0-1.7-1.81.6-1.5-1.8-1.31.6
Patch foraging water rate 12 sec1.02.02.7-1.0-1.4-1.6-1.41.4-1.4-1.5-1.41.4
Patch foraging water rate 18 sec1.82.83.7-1.3-1.9-1.7-1.61.7-1.7-1.8-1.71.6
Patch foraging water rate 24 sec4.66.57.7-2.2-2.8-2.8-2.72.5-2.5-2.6-2.52.4
Patch foraging water rate 6 sec0.60.81.2-0.5-1.0-1.1-0.80.9-0.9-1.1-0.90.8
Seeking ratio, delayed vs. immediate footshock0.81.02.1-1.4-0.8-0.6-1.21.2-0.8-1.0-0.61.1
Distance traveled before self-admin0.10.10.3-0.5-0.30.2-0.20.10.3-0.30.2-0.3
Distance traveled after self-admin1.01.31.8-1.0-1.3-1.1-1.41.1-1.1-1.1-1.20.9
Extensor digitorum longus weight0.93.74.6-0.9-2.1-2.0-2.02.0-2.0-2.0-2.02.0
Bone: elastic displacement0.20.21.5-1.2-0.2-0.1-0.10.10.1-0.10.10.1
Bone: elastic work0.91.27.9-2.80.30.50.3-0.40.90.41.0-0.5
Bone: endosteal estimation0.41.01.3-0.2-1.0-1.1-1.01.0-1.1-1.0-1.11.0
Bone: endosteal perimeter0.10.21.1-1.0-0.3-0.2-0.40.5-0.2-0.4-0.30.5
Epididymis fat weight1.24.35.2-2.3-1.9-1.9-2.22.3-1.9-2.2-2.01.9
Delta time in closed arm before/after self-admin0.80.71.1-0.2-0.8-0.9-0.60.9-1.0-0.8-1.01.0
Delta time in open arm before/after self-admin0.10.10.30.4-0.30.0-0.00.10.0-0.0-0.3-0.5
Diff in mean of infusions in LGA sessions0.10.20.40.10.40.50.3-0.30.50.20.5-0.7
Delay discount exponential model param1.21.32.8-1.7-1.4-1.0-1.11.3-0.8-1.0-1.00.8
Extinction: sum of active levers before priming0.70.81.51.20.71.00.9-0.60.90.80.5-1.2
Active lever presses in extinction session 64.14.15.01.62.02.11.8-2.02.22.22.0-2.2
Bone: final force1.82.811.0-3.3-1.5-1.2-1.61.4-1.1-1.5-0.91.4
Bone: final moment1.62.612.2-3.5-1.4-1.1-1.41.3-0.9-1.3-0.71.2
Food consumed during 24 hour testing period0.20.20.4-0.7-0.3-0.3-0.70.5-0.4-0.5-0.40.4
Glucose14.923.526.54.05.04.75.1-5.14.95.04.8-5.1
Heart weight0.10.11.0-1.00.10.0-0.1-0.10.20.00.3-0.0
Delay discount hyperbolic model param1.21.42.7-1.6-1.4-1.1-1.11.3-0.9-1.1-1.00.8
Intermittent access intake day 1-15 change0.20.41.8-1.30.20.10.3-0.40.60.30.8-0.4
Intermittent access intake escalation0.20.31.8-1.30.20.00.2-0.20.50.20.7-0.3
Intermittent access intake escalation 20.50.62.0-1.40.30.30.3-0.41.00.51.0-0.7
Intermitt. access day 1 inactive lever presses0.93.26.3-2.5-1.8-1.8-1.91.5-1.6-1.6-1.21.9
Intermitt. access day 15 inactive lever presses1.02.03.8-1.4-2.0-1.2-1.51.1-1.4-1.2-1.31.3
Intermitt. access escalation Index0.81.11.4-1.0-1.2-1.0-1.11.0-1.1-1.0-1.11.0
Intermittent access day 1 total infusions0.10.10.3-0.5-0.3-0.4-0.20.3-0.2-0.3-0.30.3
Intermittent access day 15 total infusions0.30.42.2-1.5-0.5-0.5-0.40.3-0.2-0.5-0.10.4
Intermittent access terminal intake (last 3 days)0.20.31.9-1.4-0.5-0.4-0.40.3-0.1-0.4-0.00.3
Intermittent access total infusions0.20.20.9-0.9-0.4-0.3-0.30.3-0.2-0.4-0.20.4
Intermittent access day 1 locomotion0.10.10.1-0.2-0.3-0.2-0.20.2-0.2-0.3-0.30.4
Intermittent access day 15 total locomotion0.10.21.4-1.2-0.1-0.2-0.10.10.0-0.40.20.4
Intermittent access total locomotion0.10.10.7-0.8-0.3-0.3-0.10.1-0.1-0.4-0.00.4
Intermittent access standard deviation1.02.03.10.11.51.11.4-1.51.81.51.7-1.6
Left kidney weight0.10.61.00.11.01.00.8-0.60.80.60.9-0.5
Right kidney weight0.10.30.70.20.70.80.6-0.40.60.40.5-0.4
Cocaine induced anxiety1.31.93.7-0.20.81.90.8-1.41.81.21.7-1.5
Post-drug Anxiety3.23.45.30.81.82.31.4-1.92.11.92.2-1.8
Baseline Anxiety0.70.82.01.31.40.60.9-0.80.50.90.8-0.5
Tail length1.34.915.0-3.9-2.2-1.6-2.12.1-1.6-2.1-1.32.1
Length with tail0.10.65.0-2.2-0.30.4-0.20.30.4-0.20.4-0.0
Length without tail0.82.63.90.21.51.91.6-1.52.01.61.7-1.9
Times rat made contact with spout0.70.81.4-0.71.01.10.6-0.91.00.91.2-0.8
Lifetime Intake0.00.10.3-0.6-0.2-0.1-0.10.1-0.0-0.2-0.00.1
Liver weight, left0.81.41.81.31.21.21.1-1.21.11.20.9-1.2
Liver weight, right1.22.13.5-1.9-1.6-0.9-1.61.4-1.3-1.4-1.31.6
Locomotor activity0.40.61.61.30.70.50.7-0.80.50.90.4-0.8
Locomotor testing distance0.20.42.91.70.2-0.00.3-0.4-0.00.5-0.3-0.6
Locomotor testing rearing0.10.20.60.8-0.5-0.4-0.20.1-0.4-0.1-0.60.0
Locomotion in novel chamber0.20.20.50.6-0.7-0.2-0.20.5-0.5-0.5-0.70.3
Locomotion in novel chamber post-restriction1.01.66.0-2.4-1.0-0.8-1.01.3-0.7-1.4-0.41.3
Fecal boli incidents, locomotor time 10.00.10.30.50.1-0.20.00.1-0.30.1-0.30.0
Change in fecal boli incidents, locomotor task4.14.14.61.62.12.02.1-2.12.12.02.1-2.0
Time >=10cm from walls, locomotor time 12.12.33.1-1.4-1.3-1.8-1.41.6-1.5-1.6-1.41.5
Bouts of movement, locomotor time 10.91.02.21.51.00.80.9-1.00.81.10.7-0.9
Total resting periods, locomotor time 11.61.73.01.71.31.21.3-1.41.21.41.1-1.2
Rest time, locomotor task time 11.41.72.01.11.31.41.3-1.41.31.41.4-1.2
Distance moved, locomotor task time 10.50.81.2-0.9-0.8-1.1-0.90.8-0.8-0.9-0.90.7
Vertical activity count, locomotor time 11.02.42.9-1.3-1.6-1.7-1.61.6-1.5-1.6-1.71.3
Time >=10cm from walls, locomotor time 20.00.00.2-0.40.3-0.00.10.2-0.0-0.20.10.2
Bouts of movement, locomotor time 20.10.21.01.00.20.50.4-0.40.20.40.2-0.2
Total resting periods, locomotor time 20.00.10.30.6-0.20.1-0.00.1-0.3-0.1-0.20.2
Rest time, locomotor task time 20.00.10.20.10.40.20.3-0.20.20.20.20.0
Distance moved, locomotor task time 20.00.00.2-0.1-0.2-0.4-0.30.1-0.2-0.1-0.30.1
Vertical activity count, locomotor time 20.50.71.3-0.3-0.9-1.1-0.90.9-0.9-0.8-1.00.7
Light reinforcement 12.04.86.3-1.6-2.3-2.2-2.12.5-2.2-2.5-2.41.7
Light reinforcement 21.93.03.9-1.8-1.9-1.4-1.72.0-1.6-1.9-1.81.4
Bone: marrow area0.41.01.3-0.1-1.0-1.1-1.01.0-1.1-1.0-1.11.0
Bone: maximum diameter0.30.52.2-1.5-0.5-0.2-0.50.7-0.3-0.7-0.40.7
Bone: maximum force2.03.612.0-3.5-1.6-1.5-1.91.7-1.3-1.7-1.11.7
Bone: maximum moment1.73.112.9-3.6-1.4-1.3-1.71.5-1.1-1.5-0.81.5
Mean time between licks in bursts0.20.52.01.40.60.40.6-0.60.40.60.3-0.6
Mean num. licks in bursts0.60.91.5-0.30.90.90.7-1.11.01.11.2-0.9
Cd content in liver0.80.91.30.2-0.8-1.1-1.10.9-1.1-0.9-1.01.0
Co content in liver0.00.00.00.00.20.20.0-0.10.10.10.0-0.1
Cu content in liver0.50.60.7-0.80.80.80.5-0.80.80.70.9-0.6
Fe content in liver0.10.10.50.7-0.2-0.4-0.30.2-0.3-0.2-0.60.1
K content in liver3.53.33.9-1.3-1.9-1.6-1.82.0-1.9-2.0-1.92.0
Mg content in liver4.54.65.6-0.9-2.2-2.1-2.12.3-2.3-2.4-2.32.4
Mn content in liver0.10.10.1-0.3-0.1-0.1-0.10.3-0.2-0.3-0.20.3
Na content in liver0.50.50.90.1-1.0-0.5-0.60.8-0.7-0.7-1.00.6
Rb content in liver3.43.94.9-1.9-1.9-2.0-2.02.0-1.9-2.1-1.72.2
Se content in liver0.40.50.7-0.6-0.8-0.7-0.80.7-0.7-0.7-0.70.7
Sr content in liver2.32.02.30.61.51.51.4-1.51.51.51.5-1.5
Zn content in liver1.11.22.6-1.6-1.1-0.8-1.11.0-0.9-1.1-0.71.3
Bone: minimum diameter0.51.05.2-2.3-0.5-0.3-0.90.8-0.4-0.8-0.50.8
Time in familiar zone, hab. session 10.30.30.6-0.00.70.40.6-0.60.60.60.7-0.5
Time in novel zone, hab. session 10.20.20.5-0.0-0.7-0.4-0.40.5-0.4-0.5-0.60.4
Total zone transitions, hab. session 10.10.10.30.4-0.4-0.5-0.30.3-0.4-0.2-0.40.1
Total locomotion distance, hab. session 10.70.91.3-0.4-1.1-1.1-1.11.0-1.0-0.9-1.10.9
Locomotion velocity, hab. session 10.71.11.5-0.3-1.2-1.1-1.21.0-1.1-0.9-1.20.9
Time in familiar zone, hab. session 20.10.10.30.5-0.2-0.2-0.20.0-0.2-0.1-0.20.1
Time in novel zone, hab. session 20.00.00.0-0.00.20.10.20.00.10.10.1-0.0
Total zone transitions, hab. session 21.92.53.2-0.3-1.6-1.8-1.71.6-1.8-1.5-1.71.7
Total locomotion distance, hab. session 23.54.65.4-1.1-2.3-2.2-2.32.2-2.3-2.1-2.22.3
Locomotion velocity, hab. session 23.64.95.6-1.4-2.3-2.3-2.42.3-2.3-2.1-2.22.4
Novel to familiar place preference ratio0.40.42.4-1.50.50.40.1-0.30.50.40.7-0.3
Novelty place preference0.40.52.2-1.50.60.50.1-0.40.60.50.8-0.4
Time in novel zone, NPP test0.30.31.9-1.40.40.3-0.0-0.20.40.30.6-0.2
Total zone transitions, NPP test2.33.44.40.0-2.0-2.0-1.91.8-2.1-1.7-2.11.9
Total locomotion distance, NPP test4.25.77.0-0.7-2.6-2.5-2.52.5-2.6-2.4-2.72.4
Locomotion velocity, NPP test3.24.55.3-0.8-2.3-2.3-2.22.2-2.3-2.1-2.32.1
Intraocular pressure0.81.22.5-1.6-0.7-1.2-1.10.9-1.0-0.9-0.61.3
Delta distance traveled before/after self-admin0.30.30.80.1-0.6-0.8-0.60.4-0.7-0.1-0.90.4
Delta ambulatory time before/after self-admin0.20.20.50.5-0.3-0.7-0.30.2-0.70.0-0.70.4
Parametrial fat weight0.71.51.9-1.3-1.2-1.0-1.41.4-1.2-1.4-1.11.2
Pavlov. Cond. lever latency1.11.32.10.5-1.1-1.4-1.31.0-1.4-1.0-1.31.2
Pavlov. Cond. magazine entry latency0.60.81.9-1.40.50.80.7-0.71.00.61.1-0.8
Pavlov. Cond. change in total contacts1.71.92.3-0.01.51.51.4-1.41.51.41.5-1.4
Pavlov. Cond. index score0.40.52.9-1.70.10.60.3-0.10.60.10.6-0.3
Pavlov. Cond. latency score0.50.71.8-1.40.40.90.7-0.50.90.50.9-0.7
Pavlov. Cond. lever contacts0.20.30.5-0.60.40.70.6-0.30.60.30.6-0.5
Pavlov. Cond. magazine entry number1.51.93.01.2-1.2-1.4-1.31.3-1.6-1.2-1.71.4
Pavlov. Cond. intertrial magazine entries1.61.92.5-0.9-1.3-1.5-1.51.4-1.4-1.4-1.31.6
Pavlov. Cond. lever-magazine prob. diff.0.40.42.8-1.70.10.50.3-0.10.50.10.6-0.3
Pavlov. Cond. response bias1.11.32.0-1.11.01.21.2-1.01.31.01.4-1.2
Pavlov. Cond. lever latency2.33.13.81.41.92.01.9-1.81.81.81.7-1.6
Pavlov. Cond. magazine entry latency0.40.51.21.1-0.5-0.8-0.70.4-0.8-0.4-0.90.4
Pavlov. Cond. change in total contacts0.50.91.50.1-0.9-1.2-1.10.9-1.0-0.8-1.10.6
Pavlov. Cond. index score0.60.81.4-0.0-0.9-1.2-1.10.8-1.0-0.8-1.00.6
Pavlov. Cond. latency score0.81.11.7-0.1-1.0-1.3-1.21.0-1.2-0.9-1.20.8
Pavlov. Cond. lever contacts2.02.83.7-1.2-1.7-1.9-1.81.7-1.7-1.7-1.61.5
Pavlov. Cond. magazine entry number0.40.50.8-0.90.50.80.7-0.50.80.40.9-0.3
Pavlov. Cond. intertrial magazine entries1.01.53.3-1.8-1.1-1.1-1.11.2-1.0-1.3-0.71.4
Pavlov. Cond. lever-magazine prob. diff.0.40.61.10.3-0.7-1.0-0.90.6-0.9-0.6-0.90.5
Pavlov. Cond. response bias0.91.32.0-0.4-1.1-1.4-1.31.1-1.2-1.1-1.20.9
Time in closed arm before self-admin1.11.41.70.61.31.31.2-1.21.31.01.3-1.2
Time in closed arm after self-admin1.71.82.30.91.51.31.5-1.41.41.31.5-1.1
Time in open arm before self-admin1.01.11.5-0.5-1.0-1.1-0.81.1-1.2-1.0-1.21.2
Time in open arm after self-admin0.50.51.0-0.1-0.8-0.9-0.80.7-0.8-0.6-1.00.5
Bone: periosteal estimation0.71.43.7-1.9-1.1-0.9-1.11.1-0.9-1.1-0.91.1
Bone: periosteal perimeter0.40.74.2-2.00.50.60.4-0.30.80.30.8-0.3
Bone: post-yield work0.20.30.4-0.1-0.4-0.6-0.50.6-0.5-0.6-0.50.5
Progressive ratio test 1 active lever presses0.30.31.0-1.0-0.6-0.6-0.50.5-0.4-0.5-0.40.5
Progressive ratio test 1 breakpoint0.30.41.2-1.1-0.5-0.6-0.50.5-0.4-0.5-0.40.5
Progressive ratio test 1 inactive lever presses3.14.46.6-2.6-2.3-2.2-2.12.0-1.8-2.0-1.82.0
Progressive ratio test 2 active lever presses0.30.31.0-1.0-0.2-0.7-0.40.4-0.4-0.5-0.20.7
Progressive ratio test 2 breakpoint0.30.31.1-1.0-0.2-0.7-0.40.4-0.4-0.5-0.20.6
Progressive ratio test 2 inactive lever presses0.10.10.9-0.9-0.1-0.2-0.1-0.10.1-0.00.30.2
Incentive Sensitization - Responses0.20.30.7-0.8-0.1-0.8-0.50.3-0.4-0.3-0.10.7
Incentive Sensitization - Breakpoint0.10.20.5-0.7-0.1-0.7-0.40.2-0.3-0.2-0.00.6
Sum of active levers in priming session hrs 5-60.60.51.0-0.20.90.40.2-0.70.90.91.0-0.7
Progressive ratio0.30.51.21.10.60.60.8-0.70.50.70.6-0.6
Food seeking constrained by brief footshock1.21.52.50.91.21.61.1-1.11.21.21.2-1.4
Seeking ratio, punishment vs. effort0.10.20.3-0.4-0.3-0.2-0.60.4-0.4-0.3-0.40.3
Retroperitoneal fat weight2.510.615.1-3.9-3.3-2.8-3.53.4-2.9-3.4-3.03.1
Reaction time number correct5.210.014.2-1.1-3.6-3.8-3.13.1-3.4-3.0-3.62.9
Reaction time mean minus median0.41.01.40.70.91.11.1-0.91.10.90.9-1.2
Reaction time mean minus median AUC0.00.10.20.20.00.40.4-0.20.40.20.2-0.5
Reaction time num false alarms0.10.20.40.50.70.30.3-0.40.30.50.3-0.3
Reaction time num false alarms AUC0.10.20.70.80.50.30.3-0.40.20.40.1-0.2
Reaction time trials correct on left5.210.014.2-1.1-3.6-3.8-3.13.1-3.4-3.0-3.62.9
Reaction time trials on left5.510.314.6-1.1-3.6-3.8-3.13.2-3.5-3.0-3.73.0
Reaction time mean0.20.40.6-0.5-0.7-0.5-0.70.8-0.5-0.7-0.70.3
Reaction time mean AUC0.60.91.3-0.5-1.0-0.9-1.01.1-0.9-1.1-1.10.6
Median of all reaction times0.70.91.3-0.7-1.0-0.9-1.11.1-0.9-1.1-1.00.7
Reaction time omissions0.30.40.7-0.2-0.8-0.6-0.60.7-0.6-0.6-0.90.4
Reaction time false alarm rate2.63.65.31.32.32.11.8-1.91.91.91.9-1.7
Reaction time premature initiation rate0.81.11.81.21.30.80.8-1.30.71.20.9-0.7
Reaction time premature initiations0.50.91.90.4-0.8-1.4-1.00.6-1.3-0.5-1.11.0
Std. dev. reaction times0.10.10.50.70.10.20.3-0.10.20.2-0.0-0.5
Reaction time trials completed5.510.314.6-1.1-3.6-3.8-3.13.2-3.5-3.0-3.73.0
Reaction time trials AUC5.510.414.6-1.1-3.7-3.8-3.13.2-3.5-3.1-3.73.0
Run reversals in cocaine runway, females0.20.20.60.3-0.2-0.8-0.40.2-0.7-0.1-0.70.5
Run reversals in cocaine runway, males0.30.30.6-0.70.30.70.3-0.20.70.20.8-0.3
Latency to leave start box in cocaine runway0.00.00.10.20.0-0.20.00.0-0.3-0.1-0.20.2
Latency to leave start box in cocaine runway, F1.11.22.0-0.1-0.9-1.3-1.01.1-1.4-1.1-1.41.2
Latency to leave start box in cocaine runway, M0.60.50.90.20.70.70.7-0.80.80.81.0-0.6
Std. dev. time between licks in bursts4.86.58.0-1.3-2.6-2.8-2.62.7-2.7-2.6-2.82.5
Total sessions with >9 infusions0.10.10.20.3-0.10.20.5-0.30.30.40.0-0.4
Short access day 1 total inactive lever presses0.30.40.7-0.1-0.5-0.5-0.60.6-0.8-0.7-0.80.8
Short access day 10 total inactive lever presses1.02.54.1-1.9-1.6-1.2-1.81.4-1.4-1.4-1.02.0
Short access day 1 total infusions0.40.51.41.20.40.50.8-0.60.40.70.2-0.8
Short access day 10 total infusions0.20.21.6-1.3-0.4-0.2-0.30.30.0-0.30.10.4
Short access total infusions0.00.00.1-0.0-0.20.10.1-0.10.20.1-0.0-0.3
Short access day 1 locomotion0.40.50.80.30.60.60.9-0.60.80.70.6-0.9
Short access day 10 total locomotion0.81.62.20.51.11.31.4-1.21.51.31.4-1.3
Short access total locomotion0.70.81.3-0.10.80.81.1-0.81.10.91.0-1.0
One hour access (0.3 mA shock)0.50.61.4-1.2-0.6-0.9-0.60.7-0.7-0.8-0.60.7
Compulsive drug intake1.82.12.8-1.0-1.7-1.5-1.51.4-1.5-1.6-1.51.2
One hour access (shock baseline)0.00.10.3-0.60.0-0.2-0.00.2-0.2-0.1-0.10.3
Social response proportion0.10.10.20.5-0.3-0.3-0.1-0.1-0.30.1-0.30.1
Social responses0.10.20.50.6-0.5-0.1-0.10.3-0.4-0.3-0.7-0.1
Social time0.10.10.20.2-0.2-0.4-0.10.2-0.4-0.1-0.50.3
Soleus weight0.61.85.1-2.3-1.4-0.9-1.31.2-0.9-1.2-0.81.2
Bone: stiffness0.50.81.3-1.1-0.7-0.8-1.01.0-0.8-0.9-0.70.9
Tibialis anterior weight0.20.60.9-0.4-0.9-0.7-0.70.8-0.8-0.8-0.80.9
Time to tail flick, vehicle, before self-admin0.10.10.20.50.40.50.5-0.20.20.20.2-0.2
Time to tail flick, vehicle, after self-admin0.60.72.41.50.70.90.9-0.90.40.80.4-0.7
Time to tail flick, test, before self-admin0.50.51.00.30.50.90.5-1.00.60.80.9-0.1
Time to tail flick, test, after self-admin2.12.13.11.51.31.81.4-1.61.41.61.4-1.2
Delta time to tail flick, vehicle, before/after SA0.30.30.6-0.0-0.8-0.5-0.50.3-0.7-0.4-0.70.5
Delta time to tail flick, test, before/after SA1.11.11.41.11.11.01.1-0.91.11.00.9-1.2
Tibia length1.33.628.0-5.3-0.8-0.6-1.10.9-0.1-0.90.10.8
Ambulatory time before self-admin0.30.41.5-1.2-0.8-0.2-0.70.7-0.1-0.8-0.20.2
Ambulatory time after self-admin0.60.71.1-0.7-1.0-0.9-1.00.8-0.8-0.8-0.90.6
Bone: tissue strength2.12.13.1-1.8-1.3-1.3-1.51.5-1.3-1.5-1.31.5
Total heroin consumption0.81.02.20.80.81.20.7-0.91.11.00.7-1.5
Bone: trabecular number0.00.00.0-0.10.00.20.1-0.00.1-0.00.2-0.0
Bone: trabecular spacing4.15.46.7-0.8-2.5-2.5-2.52.4-2.5-2.3-2.62.4
Bone: trabecular thickness1.62.02.9-0.51.51.51.4-1.41.61.41.7-1.4
Bone: trabecular tissue density0.20.31.31.10.50.40.4-0.30.20.30.2-0.5
Water consumed over 24 hours1.01.42.00.61.31.41.2-1.21.21.21.2-1.2
Number of responses in last shaping day0.00.00.1-0.2-0.3-0.10.0-0.10.00.1-0.2-0.2