Hub : Genes

Ptprn2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC alternative polyA NM_031600.2 0.09 0.08 8.6e-04 0.09 0.06 0.1 0.09 1.2e-04 1.0e-03 7.6e-05 1.9e-04
2 IC alternative polyA NM_031600.2 0.09 0.09 2.7e-03 0.08 0.05 0.1 0.08 2.3e-04 3.3e-03 4.0e-05 3.3e-04
3 NAcc gene expression Ptprn2 0.06 0.04 1.5e-12 0.09 0.09 0.08 0.08 4.5e-13 7.7e-13 2.2e-12 1.4e-12
4 IC alternative polyA XM_039111861.2 0.07 0.08 6.7e-03 0.07 0.04 0.08 0.07 6.1e-04 7.4e-03 2.1e-04 9.7e-04
5 NAcc alternative polyA XM_039111861.2 0.02 0.03 7.1e-03 0.01 0.01 0.01 0.01 3.0e-03 5.1e-03 3.5e-03 2.6e-03
6 PL isoform ratio NM_031600.2 0.03 0.03 2.6e-03 0.02 0.02 0.02 0.02 2.7e-03 3.0e-03 4.0e-03 2.9e-03
7 PL isoform ratio XM_039111862.2 0.06 0.05 4.1e-07 0.06 0.06 0.06 0.06 2.6e-07 1.6e-07 2.5e-07 5.1e-07
8 pVTA isoform ratio XM_039111863.2 0.13 0.23 3.8e-04 0.05 0.05 0.05 0.05 7.5e-05 1.3e-04 7.4e-05 6.0e-05
9 NAcc alternative polyA NM_031600.2 0.03 0.03 3.3e-03 0.02 0.01 0.01 0.02 7.3e-04 2.0e-03 3.2e-03 8.6e-04
10 NAcc alternative polyA XM_039111861.2 0.02 0.03 6.9e-03 0.02 0.01 0.01 0.02 1.1e-03 4.4e-03 2.2e-03 1.3e-03
11 Liver gene expression Ptprn2 0.19 0.1 0.0e+00 0.2 0.21 0.22 0.21 9.4e-22 2.9e-23 1.4e-23 5.3e-23
12 PL alternative polyA XM_039111861.2 0.07 0.09 3.9e-05 0.04 0.04 0.04 0.04 4.4e-05 2.1e-05 4.2e-05 4.2e-05
13 PL alternative polyA XM_039111861.2 0.08 0.09 4.7e-05 0.04 0.04 0.04 0.04 5.7e-05 3.2e-05 5.7e-05 5.2e-05
14 NAcc isoform ratio XM_039111862.2 0.03 0.03 1.8e-05 0.03 0.03 0.03 0.03 1.4e-05 1.8e-05 1.4e-05 1.5e-05
15 PL alternative polyA NM_031600.2 0.09 0.12 6.2e-05 0.04 0.04 0.04 0.04 7.6e-05 4.6e-05 7.1e-05 7.3e-05
16 PL alternative polyA NM_031600.2 0.09 0.12 4.0e-05 0.04 0.04 0.04 0.04 4.8e-05 2.5e-05 3.9e-05 4.4e-05
17 IC alternative polyA XM_039111861.2 0.07 0.07 2.6e-03 0.07 0.05 0.04 0.07 4.5e-04 3.6e-03 9.9e-03 8.6e-04
18 NAcc alternative polyA NM_031600.2 0.03 0.04 3.8e-03 0.02 0.01 0.01 0.01 1.5e-03 2.6e-03 2.0e-03 1.8e-03
19 IL mRNA stability Ptprn2 0.2 0.17 5.8e-04 0.16 0.14 0.17 0.08 1.0e-04 3.8e-04 8.3e-05 5.2e-03
20 IL isoform ratio XM_039111862.2 0.19 0.16 9.0e-04 0.09 0.09 0.1 0.04 3.2e-03 3.7e-03 2.7e-03 4.7e-02
21 Brain gene expression Ptprn2 0.75 0.02 4.0e-05 0.04 0.01 0.05 0 2.3e-04 1.8e-02 2.9e-05 3.5e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density0.40.71.00.50.51.0-0.5-0.81.0-0.90.90.8-0.80.8-0.9-0.9-0.90.90.9-0.70.8-0.6-1.00.8
Area under the delay curve0.80.91.7-0.8-1.0-0.91.11.1-1.01.0-0.9-1.01.0-1.20.80.80.9-0.7-0.71.2-1.21.30.6-0.3
BMI with tail0.00.10.20.20.10.1-0.00.3-0.00.1-0.2-0.30.3-0.3-0.0-0.10.20.10.10.4-0.40.5-0.50.2
BMI without tail0.20.50.9-0.3-0.4-0.70.40.8-0.60.7-0.8-0.90.9-0.70.70.71.0-0.7-0.70.7-0.60.60.7-0.8
Body weight3.214.116.5-3.6-3.6-3.83.64.0-3.83.9-4.0-4.14.1-3.93.73.73.9-3.7-3.73.7-3.83.53.5-3.2
Weight adjusted by age1.21.92.3-1.2-1.2-1.51.21.4-1.51.5-1.4-1.41.4-1.31.51.51.5-1.5-1.51.3-1.41.31.2-1.4
Bone surface3.87.08.12.62.52.9-2.5-2.62.8-2.72.72.7-2.72.7-2.8-2.8-2.72.82.8-2.42.5-2.4-2.72.4
Bone volume2.64.75.72.12.02.4-2.0-2.22.3-2.22.22.2-2.22.2-2.3-2.3-2.32.32.3-2.02.1-2.0-2.11.9
Breakpoint value in progressive ratio session3.84.66.1-2.5-2.4-2.22.32.1-2.02.2-1.9-1.91.9-2.12.22.22.1-2.2-2.22.4-2.42.41.2-1.7
Number of licking bursts0.20.30.50.40.40.7-0.4-0.50.6-0.50.50.5-0.50.5-0.6-0.6-0.60.70.7-0.50.5-0.4-0.40.7
Context. condit. distance diff. score1.11.32.1-1.5-1.4-1.01.41.1-1.01.1-1.0-1.01.0-1.11.11.11.1-1.1-1.11.3-1.41.21.0-0.8
Locomotion velocity, session 10.00.00.1-0.1-0.1-0.10.10.1-0.10.2-0.2-0.10.1-0.10.20.20.2-0.2-0.20.1-0.20.2-0.0-0.2
Locomotion distance, session 10.60.81.21.11.00.9-1.0-0.80.8-0.90.70.8-0.80.9-0.9-0.9-0.90.90.9-1.00.9-0.9-0.70.8
Locomotion velocity, session 20.30.30.80.90.80.5-0.8-0.50.4-0.50.40.5-0.50.5-0.5-0.5-0.50.50.5-0.50.6-0.5-0.70.5
Locomotion distance, session 22.94.05.52.32.32.0-2.3-2.02.0-2.01.81.9-1.92.0-2.0-2.0-2.02.02.0-2.02.0-1.9-1.91.7
Locomotion velocity, session 30.10.10.50.40.30.4-0.3-0.30.3-0.40.40.4-0.40.4-0.4-0.4-0.40.40.4-0.20.1-0.2-0.70.5
Locomotion distance, session 30.00.00.1-0.1-0.10.10.1-0.10.0-0.10.10.1-0.10.1-0.1-0.1-0.10.10.1-0.0-0.00.0-0.30.4
Stereotopy head waving bouts, day 30.00.00.1-0.1-0.1-0.20.10.2-0.10.2-0.1-0.10.1-0.20.20.20.2-0.2-0.20.3-0.30.3-0.1-0.3
Stereotopy head waving duration, day 30.00.00.00.10.1-0.0-0.1-0.10.10.00.10.1-0.10.00.10.1-0.0-0.1-0.10.1-0.10.1-0.2-0.1
Locomotion velocity, session 70.10.10.3-0.1-0.2-0.10.20.3-0.10.3-0.1-0.20.2-0.30.20.20.2-0.2-0.20.4-0.50.5-0.3-0.2
Locomotion distance, session 70.10.10.40.30.30.4-0.2-0.30.4-0.30.40.3-0.30.3-0.4-0.4-0.40.40.4-0.10.1-0.1-0.60.3
Stereotopy head waving bouts, day 71.11.22.4-1.6-1.5-1.01.51.1-1.01.0-1.0-1.01.0-1.10.90.91.0-0.9-0.91.2-1.21.40.5-0.3
Stereotopy head waving duration, day 70.30.30.8-0.9-0.9-0.50.80.6-0.60.5-0.6-0.50.5-0.60.50.50.5-0.5-0.50.6-0.60.70.3-0.1
Locomotion velocity, session 80.00.00.30.30.20.2-0.10.00.0-0.0-0.00.1-0.1-0.1-0.1-0.1-0.10.20.20.1-0.20.2-0.50.4
Locomotion distance, session 80.71.01.40.80.81.1-0.8-1.01.1-1.11.11.2-1.21.1-1.0-1.0-1.11.01.0-0.80.7-0.8-1.10.9
Degree of sensitization distance0.30.30.50.60.60.7-0.5-0.50.7-0.60.60.6-0.60.5-0.6-0.7-0.60.70.7-0.30.4-0.3-0.60.5
Degree of sensitization stereotypy0.20.30.6-0.8-0.8-0.40.80.5-0.50.4-0.5-0.40.4-0.50.40.40.4-0.4-0.40.5-0.50.60.3-0.0
Conditioned locomotion0.30.30.6-0.6-0.5-0.50.50.6-0.50.6-0.5-0.50.5-0.60.60.60.6-0.6-0.60.7-0.80.60.4-0.4
Cocaine response after cond. corrected0.40.40.70.30.40.8-0.4-0.70.9-0.70.80.8-0.80.7-0.7-0.7-0.70.70.7-0.50.4-0.5-0.70.7
Cocaine response after cond. not corrected0.81.01.40.70.71.1-0.7-1.01.2-1.11.11.1-1.11.0-1.1-1.1-1.11.11.1-0.90.8-0.8-1.11.1
Cocaine response before conditioning0.20.20.40.60.60.3-0.6-0.50.3-0.40.50.5-0.50.4-0.4-0.4-0.40.40.4-0.60.5-0.4-0.30.3
Saline control response0.20.20.5-0.3-0.4-0.50.40.5-0.40.6-0.5-0.50.5-0.50.50.50.5-0.5-0.50.4-0.50.40.7-0.3
Bone: connectivity density0.71.11.50.80.81.2-0.8-1.01.2-1.11.11.0-1.01.0-1.1-1.1-1.11.11.2-0.90.9-0.7-1.21.2
Bone: cortical apparent density2.73.74.5-2.1-2.1-1.92.12.0-1.91.9-1.8-1.91.9-1.91.91.91.9-1.9-1.92.1-2.12.01.5-1.3
Bone: cortical area1.52.33.01.71.71.7-1.6-1.51.6-1.51.51.5-1.51.5-1.6-1.6-1.61.61.6-1.41.4-1.6-1.31.2
Bone: cortical porosity0.10.10.4-0.0-0.1-0.40.10.4-0.30.4-0.5-0.40.4-0.50.40.40.4-0.4-0.40.3-0.20.10.7-0.6
Bone: cortical porosity0.20.20.6-0.3-0.3-0.50.30.5-0.40.5-0.5-0.50.5-0.60.50.50.5-0.5-0.50.4-0.40.30.7-0.6
Bone: cortical thickness0.00.10.20.30.20.3-0.1-0.10.2-0.20.20.2-0.20.2-0.2-0.2-0.20.30.30.1-0.10.0-0.40.4
Bone: cortical thickness0.50.60.70.60.70.9-0.6-0.80.8-0.80.90.9-0.90.8-0.8-0.8-0.80.80.8-0.80.7-0.7-0.60.7
Bone: cortical tissue density2.63.54.3-2.1-2.1-1.82.11.9-1.81.9-1.8-1.81.8-1.81.91.91.9-1.9-1.92.0-2.02.01.5-1.3
Condit. Reinf. active minus inactive responses0.10.10.2-0.3-0.3-0.20.40.3-0.20.2-0.2-0.30.3-0.40.20.20.2-0.2-0.20.4-0.40.50.2-0.1
Condit. Reinf. active-inactive response ratio0.10.10.2-0.5-0.5-0.10.40.3-0.20.2-0.2-0.30.3-0.30.10.10.2-0.1-0.10.3-0.30.50.20.2
Condit. Reinf. active responses0.00.00.10.10.1-0.1-0.00.1-0.10.1-0.0-0.10.1-0.20.20.20.1-0.2-0.20.1-0.10.10.2-0.3
Condit. Reinf. inactive responses0.10.10.40.60.60.1-0.6-0.20.1-0.10.20.2-0.20.20.00.0-0.1-0.1-0.1-0.30.3-0.4-0.1-0.5
Incentive salience index mean0.20.20.3-0.4-0.4-0.40.50.5-0.40.5-0.5-0.50.5-0.50.50.50.5-0.5-0.50.5-0.50.50.4-0.4
Condit. Reinf. lever presses0.30.40.7-0.4-0.4-0.60.50.7-0.60.6-0.7-0.80.8-0.60.60.60.7-0.6-0.60.5-0.40.40.6-0.8
Condit. Reinf. active minus inactive responses0.00.00.20.40.4-0.0-0.3-0.00.00.1-0.1-0.10.1-0.00.10.10.1-0.1-0.1-0.10.1-0.40.3-0.4
Condit. Reinf. active-inactive response ratio0.30.40.80.90.90.6-0.9-0.60.6-0.60.50.5-0.50.6-0.6-0.6-0.60.60.6-0.70.7-0.9-0.20.2
Condit. Reinf. active responses0.10.20.70.90.80.2-0.7-0.30.3-0.20.20.2-0.20.3-0.1-0.1-0.20.10.1-0.40.4-0.80.2-0.4
Condit. Reinf. inactive responses0.20.30.60.80.70.3-0.7-0.50.5-0.40.50.5-0.50.5-0.4-0.4-0.40.30.3-0.50.5-0.7-0.3-0.0
Condit. Reinf. lever presses2.63.67.32.72.51.9-2.4-1.71.9-1.81.71.7-1.71.7-1.9-1.9-1.81.91.9-1.71.7-2.0-1.61.2
Condit. Reinf. lever reinforcers received0.20.21.01.00.90.3-0.9-0.40.4-0.30.30.3-0.30.3-0.2-0.2-0.30.20.2-0.50.5-0.80.1-0.3
Conditioned reinforcement - actives0.20.41.0-0.9-0.9-0.61.00.5-0.50.6-0.3-0.50.5-0.40.70.70.6-0.7-0.80.8-0.40.40.2-0.8
Conditioned reinforcement - inactives1.42.13.3-1.6-1.6-1.41.61.3-1.31.4-1.2-1.31.3-1.21.61.61.5-1.6-1.61.2-1.10.91.7-1.8
Conditioned locomotion0.20.20.5-0.6-0.6-0.60.60.4-0.50.4-0.3-0.40.4-0.30.60.60.5-0.6-0.60.4-0.30.30.4-0.7
Patch foraging indifference point 0 sec2.03.84.7-1.7-1.8-2.11.81.9-1.92.0-1.8-1.91.9-1.92.12.12.0-2.1-2.11.8-1.71.52.1-2.2
Patch foraging indifference point AUC0.60.91.6-1.2-1.1-1.01.10.8-1.00.8-0.8-0.70.7-0.61.01.00.9-1.1-1.10.9-0.80.60.9-1.3
Delay disc. indifference point, 0s delay0.50.60.8-0.6-0.6-0.70.60.8-0.70.8-0.8-0.90.9-0.90.70.70.9-0.7-0.70.7-0.80.70.8-0.9
Delay disc. indifference point, 16s delay0.10.10.6-0.3-0.4-0.10.50.3-0.20.3-0.1-0.10.1-0.40.10.10.2-0.1-0.10.6-0.60.8-0.40.1
Delay disc. indifference point, 2s delay0.60.71.01.00.91.0-0.8-0.60.9-0.80.80.6-0.60.6-1.0-1.0-0.81.01.0-0.70.6-0.5-0.71.0
Delay disc. indifference point, 24s delay0.20.30.50.70.70.5-0.7-0.60.4-0.50.50.6-0.60.4-0.4-0.4-0.50.40.4-0.60.7-0.6-0.30.1
Delay disc. indifference point, 4s delay1.61.72.2-1.2-1.3-1.31.41.4-1.51.3-1.2-1.41.4-1.41.21.11.3-1.1-1.11.4-1.51.41.1-0.7
Delay disc. indifference point, 8s delay1.51.83.0-1.2-1.4-1.31.51.6-1.31.4-1.4-1.51.5-1.51.11.11.3-1.0-1.01.6-1.71.70.7-0.4
Indifference point function ln k1.73.04.2-1.3-1.3-1.71.31.9-1.81.9-1.9-1.91.9-2.01.71.71.8-1.7-1.71.6-1.81.71.8-1.5
Indifference point function log k1.73.04.2-1.3-1.3-1.71.31.9-1.81.9-1.9-1.91.9-2.01.71.71.8-1.7-1.71.6-1.81.71.8-1.5
Patch foraging total patch changes 0 sec2.85.36.0-2.0-2.2-2.52.22.3-2.32.4-2.2-2.32.3-2.32.42.42.4-2.4-2.42.2-2.21.92.4-2.4
Patch foraging total patch changes 12 sec1.41.83.0-1.7-1.6-1.51.61.1-1.11.4-1.0-1.01.0-1.11.51.51.3-1.5-1.51.4-1.21.20.8-1.4
Patch foraging total patch changes 18 sec0.10.10.3-0.1-0.2-0.40.30.3-0.30.4-0.2-0.20.2-0.30.30.30.3-0.3-0.30.5-0.50.30.0-0.3
Patch foraging total patch changes 24 sec0.20.30.50.60.50.4-0.4-0.60.5-0.50.60.6-0.60.6-0.5-0.5-0.50.50.5-0.40.6-0.7-0.30.2
Patch foraging total patch changes 6 sec1.11.72.2-1.4-1.4-1.51.51.1-1.41.3-1.1-1.11.1-1.11.41.41.3-1.4-1.41.4-1.20.91.3-1.3
Patch foraging time to switch 0 sec3.26.67.32.62.52.6-2.6-2.62.6-2.62.52.5-2.52.5-2.7-2.7-2.62.72.7-2.72.6-2.3-2.42.6
Patch foraging water rate 0 sec5.411.312.3-3.3-3.3-3.43.33.4-3.33.4-3.4-3.33.3-3.43.43.43.4-3.4-3.43.5-3.43.23.2-3.3
Patch foraging water rate 12 sec4.49.210.3-2.9-3.0-3.23.03.1-3.13.1-3.0-3.03.0-3.23.03.03.0-3.0-3.03.2-3.23.02.7-2.6
Patch foraging water rate 18 sec4.57.07.9-2.6-2.7-2.62.62.7-2.62.7-2.6-2.62.6-2.72.72.72.7-2.7-2.72.8-2.82.72.2-2.1
Patch foraging water rate 24 sec2.94.15.9-2.1-2.1-2.02.22.1-2.02.1-1.9-1.91.9-2.12.02.02.0-2.0-2.02.4-2.42.41.4-1.3
Patch foraging water rate 6 sec3.04.46.7-2.0-2.1-2.02.12.3-1.92.2-2.1-2.02.0-2.32.02.02.0-1.9-1.92.6-2.62.51.5-1.4
Seeking ratio, delayed vs. immediate footshock0.10.10.10.20.30.1-0.4-0.20.0-0.30.20.2-0.20.3-0.3-0.3-0.30.30.3-0.30.2-0.2-0.20.3
Distance traveled before self-admin0.20.31.7-0.0-0.20.70.3-0.10.6-0.40.30.3-0.30.1-0.7-0.7-0.40.80.80.3-0.30.4-0.91.3
Distance traveled after self-admin0.10.10.6-0.5-0.50.20.6-0.00.2-0.00.30.3-0.3-0.0-0.2-0.2-0.30.20.20.5-0.50.5-0.80.5
Extensor digitorum longus weight1.76.88.0-2.4-2.4-2.62.42.7-2.72.6-2.8-2.82.8-2.62.62.62.7-2.6-2.62.5-2.42.42.7-2.6
Bone: elastic displacement1.21.41.61.01.01.2-1.0-1.21.2-1.21.21.2-1.21.2-1.2-1.2-1.21.21.2-1.11.2-1.0-1.01.2
Bone: elastic work1.72.23.51.31.21.6-1.2-1.41.6-1.61.51.5-1.51.4-1.7-1.7-1.61.71.7-1.11.2-1.1-1.61.9
Bone: endosteal estimation2.96.48.12.62.62.6-2.7-2.72.6-2.62.62.6-2.62.6-2.5-2.5-2.52.42.4-2.72.9-2.8-1.81.6
Bone: endosteal perimeter1.94.05.22.12.12.0-2.1-2.12.0-2.02.02.0-2.02.1-1.9-1.9-2.01.91.9-2.12.2-2.3-1.51.1
Epididymis fat weight0.20.73.41.00.60.9-0.5-0.40.8-0.70.50.4-0.40.4-1.0-1.1-0.41.11.1-0.30.2-0.1-1.21.9
Delta time in closed arm before/after self-admin0.10.10.50.30.20.2-0.2-0.10.1-0.10.20.2-0.20.1-0.3-0.3-0.50.30.30.1-0.00.2-0.70.6
Delta time in open arm before/after self-admin0.20.20.60.30.30.6-0.3-0.10.6-0.4-0.00.0-0.00.2-0.5-0.5-0.40.60.6-0.30.2-0.2-0.20.8
Diff in mean of infusions in LGA sessions1.21.52.2-1.2-1.2-1.21.11.4-1.11.3-1.5-1.41.4-1.41.11.11.3-1.0-1.01.3-1.31.50.8-0.5
Delay discount exponential model param0.91.11.80.91.11.0-1.2-1.21.1-1.11.01.1-1.11.3-0.9-0.8-1.00.80.8-1.21.3-1.3-0.70.4
Extinction: sum of active levers before priming0.20.20.6-0.6-0.7-0.20.70.3-0.10.2-0.1-0.10.1-0.30.10.10.1-0.0-0.00.7-0.60.8-0.60.8
Active lever presses in extinction session 62.62.54.0-2.0-1.9-1.71.81.5-1.61.6-1.6-1.41.4-1.51.61.61.4-1.6-1.61.8-1.71.80.6-1.1
Bone: final force0.81.21.61.11.11.3-1.1-1.11.2-1.21.21.1-1.11.1-1.2-1.2-1.21.21.2-1.01.1-1.1-0.80.8
Bone: final moment0.71.11.41.11.11.2-1.1-1.01.1-1.11.11.0-1.01.0-1.1-1.1-1.11.11.1-1.01.0-1.1-0.70.7
Food consumed during 24 hour testing period2.73.74.5-2.1-2.1-1.82.02.0-1.82.0-2.0-2.02.0-2.01.91.91.9-1.8-1.82.0-1.81.81.9-1.6
Glucose0.20.30.5-0.7-0.7-0.50.60.5-0.50.6-0.5-0.50.5-0.60.60.60.5-0.6-0.60.4-0.50.50.5-0.6
Heart weight0.00.00.10.30.20.3-0.20.00.3-0.10.2-0.00.0-0.0-0.2-0.3-0.30.30.30.0-0.00.0-0.30.3
Delay discount hyperbolic model param0.80.81.50.80.90.9-1.0-1.11.0-0.90.91.0-1.01.2-0.7-0.7-0.90.70.7-1.11.2-1.2-0.60.2
Intermittent access intake day 1-15 change0.10.30.40.60.50.7-0.5-0.50.6-0.60.50.6-0.60.5-0.6-0.6-0.50.60.6-0.60.5-0.5-0.40.1
Intermittent access intake escalation0.30.50.90.90.80.8-0.8-0.70.8-0.70.60.7-0.70.7-0.7-0.7-0.50.70.7-0.90.8-1.0-0.2-0.1
Intermittent access intake escalation 20.10.10.30.20.10.5-0.1-0.20.4-0.40.10.2-0.20.2-0.5-0.5-0.20.50.5-0.20.2-0.2-0.20.3
Intermitt. access day 1 inactive lever presses0.10.20.50.70.70.3-0.6-0.40.4-0.40.50.4-0.40.4-0.3-0.3-0.30.30.3-0.50.5-0.7-0.1-0.3
Intermitt. access day 15 inactive lever presses0.71.52.4-1.1-1.2-1.01.21.5-1.11.3-1.4-1.51.5-1.41.11.11.2-1.0-1.01.3-1.31.21.1-1.1
Intermitt. access escalation Index0.10.21.20.30.3-0.4-0.30.2-0.40.3-0.2-0.30.3-0.20.40.40.3-0.5-0.5-0.20.0-0.20.8-1.1
Intermittent access day 1 total infusions0.00.00.1-0.1-0.1-0.30.10.3-0.20.2-0.1-0.30.3-0.20.30.30.1-0.3-0.30.1-0.10.10.30.1
Intermittent access day 15 total infusions0.10.20.80.1-0.0-0.5-0.00.4-0.40.4-0.3-0.50.5-0.30.50.50.4-0.5-0.5-0.1-0.0-0.10.9-0.9
Intermittent access terminal intake (last 3 days)0.10.20.4-0.1-0.2-0.50.30.5-0.40.5-0.3-0.60.6-0.40.40.40.4-0.4-0.40.2-0.30.20.6-0.4
Intermittent access total infusions0.30.30.5-0.6-0.6-0.70.60.6-0.60.6-0.4-0.60.6-0.50.60.60.5-0.6-0.60.4-0.40.40.6-0.3
Intermittent access day 1 locomotion0.70.92.11.41.40.6-1.4-0.90.7-0.80.90.8-0.80.9-0.5-0.5-0.70.50.5-1.31.2-1.40.2-0.2
Intermittent access day 15 total locomotion0.40.71.10.90.90.9-0.8-0.80.9-0.90.90.8-0.80.9-0.8-0.8-0.90.80.8-1.00.9-0.9-0.50.5
Intermittent access total locomotion0.30.40.80.60.70.5-0.7-0.70.6-0.60.70.6-0.60.7-0.5-0.5-0.60.40.4-0.90.8-0.9-0.00.1
Intermittent access standard deviation1.22.64.1-1.9-2.0-1.42.01.8-1.41.6-1.5-1.71.7-1.71.41.41.5-1.4-1.42.0-1.92.00.7-0.7
Left kidney weight1.25.46.9-2.4-2.3-2.32.32.5-2.52.4-2.6-2.62.6-2.42.32.32.0-2.3-2.32.2-2.22.12.2-1.7
Right kidney weight1.56.78.4-2.5-2.5-2.52.42.8-2.62.6-2.8-2.92.9-2.72.62.62.6-2.6-2.62.3-2.42.12.8-2.4
Cocaine induced anxiety0.20.30.8-0.4-0.4-0.60.40.4-0.50.6-0.4-0.30.3-0.40.70.70.6-0.7-0.80.3-0.40.30.7-0.9
Post-drug Anxiety0.00.00.0-0.2-0.1-0.00.1-0.00.1-0.00.00.0-0.00.00.10.10.1-0.1-0.1-0.20.1-0.10.20.1
Baseline Anxiety0.70.81.30.70.81.1-0.8-0.81.0-1.00.70.7-0.70.8-1.1-1.1-0.81.11.1-1.01.0-0.8-0.81.2
Tail length2.610.213.3-3.4-3.3-3.33.33.1-3.23.2-3.2-3.23.2-3.13.33.33.3-3.3-3.32.8-2.82.53.7-2.9
Length with tail5.724.828.8-5.4-5.3-5.15.35.1-5.15.1-5.2-5.15.1-5.05.05.04.8-5.0-5.04.7-4.74.55.1-4.1
Length without tail3.812.214.4-3.8-3.8-3.53.83.7-3.63.6-3.7-3.73.7-3.63.43.43.2-3.3-3.33.5-3.53.43.2-2.6
Times rat made contact with spout1.51.82.9-1.1-1.2-1.11.31.5-1.31.5-1.4-1.41.4-1.71.21.21.3-1.1-1.11.7-1.61.70.7-0.9
Lifetime Intake0.10.20.2-0.4-0.5-0.50.50.4-0.40.5-0.2-0.50.5-0.40.40.40.3-0.4-0.40.3-0.40.40.40.0
Liver weight, left1.72.75.4-1.2-1.2-1.81.11.5-1.71.7-1.6-1.61.6-1.51.91.91.9-1.9-1.91.2-1.20.82.3-2.2
Liver weight, right4.17.18.6-2.7-2.5-2.92.52.6-2.72.7-2.8-2.72.7-2.62.82.82.9-2.9-2.92.2-2.32.12.9-2.9
Locomotor activity0.30.51.20.20.40.9-0.3-0.71.1-0.70.90.8-0.80.7-0.7-0.7-0.70.70.7-0.50.4-0.3-1.00.8
Locomotor testing distance0.40.71.60.60.61.0-0.5-0.61.0-0.70.80.8-0.80.7-0.9-0.9-0.80.90.9-0.40.3-0.2-1.21.3
Locomotor testing rearing1.02.13.11.31.21.7-1.1-1.41.7-1.41.61.5-1.51.4-1.6-1.6-1.51.61.6-1.11.1-1.0-1.81.7
Locomotion in novel chamber0.40.50.8-0.5-0.6-0.70.50.9-0.70.8-0.9-0.90.9-0.90.60.60.5-0.5-0.50.7-0.70.90.40.2
Locomotion in novel chamber post-restriction2.64.36.12.12.22.0-2.2-2.32.1-2.22.32.3-2.32.4-1.9-1.9-2.01.81.8-2.22.2-2.5-1.30.8
Fecal boli incidents, locomotor time 10.10.21.0-0.3-0.2-0.40.20.3-0.50.4-0.2-0.30.3-0.20.60.60.4-0.6-0.60.0-0.2-0.00.7-1.0
Change in fecal boli incidents, locomotor task0.60.61.3-0.7-0.8-0.80.80.9-0.80.8-1.0-0.90.9-1.00.50.50.6-0.4-0.41.2-1.01.10.40.2
Time >=10cm from walls, locomotor time 18.69.214.8-2.9-2.7-3.32.52.8-3.23.0-3.3-3.03.0-2.93.33.33.2-3.4-3.42.2-2.21.93.8-3.5
Bouts of movement, locomotor time 10.50.61.2-0.7-0.7-0.90.70.7-0.80.8-0.8-0.80.8-0.70.90.90.9-0.9-0.90.7-0.60.60.7-1.1
Total resting periods, locomotor time 10.10.10.6-0.00.0-0.3-0.00.0-0.20.1-0.1-0.10.10.00.30.30.3-0.3-0.3-0.00.1-0.20.3-0.8
Rest time, locomotor task time 10.30.31.0-0.6-0.5-0.70.40.4-0.60.5-0.5-0.50.5-0.40.70.70.5-0.7-0.80.4-0.20.20.5-1.0
Distance moved, locomotor task time 11.52.24.91.51.41.4-1.3-1.31.4-1.41.41.4-1.41.3-1.6-1.7-1.71.71.7-1.21.2-1.0-1.62.2
Vertical activity count, locomotor time 10.61.62.61.41.31.1-1.2-1.21.0-1.21.31.2-1.21.2-1.3-1.3-1.31.31.3-1.21.1-1.0-1.21.6
Time >=10cm from walls, locomotor time 20.71.03.0-1.0-0.7-1.10.60.7-1.00.8-1.2-1.01.0-0.71.01.11.0-1.1-1.10.3-0.20.11.7-1.7
Bouts of movement, locomotor time 21.01.52.50.91.01.3-0.9-1.41.4-1.41.61.5-1.51.5-1.2-1.2-0.91.11.1-1.21.3-1.3-1.30.5
Total resting periods, locomotor time 20.40.71.40.50.60.8-0.6-1.00.9-1.01.21.1-1.11.1-0.7-0.7-0.60.70.7-0.80.9-0.9-0.80.1
Rest time, locomotor task time 21.72.23.0-1.5-1.5-1.71.51.5-1.51.6-1.5-1.51.5-1.61.51.51.4-1.5-1.51.7-1.51.70.9-0.9
Distance moved, locomotor task time 22.42.93.61.41.51.8-1.5-1.81.8-1.81.81.7-1.71.9-1.7-1.7-1.81.71.7-1.81.8-1.8-1.51.4
Vertical activity count, locomotor time 20.81.11.70.90.91.0-0.9-1.20.9-1.11.11.1-1.11.3-1.0-1.0-1.11.00.9-1.21.2-1.3-0.90.7
Light reinforcement 10.00.00.2-0.2-0.20.10.2-0.10.0-0.20.20.1-0.10.1-0.2-0.2-0.10.20.20.1-0.10.1-0.40.4
Light reinforcement 20.20.40.9-0.9-0.8-0.60.80.6-0.70.5-0.5-0.60.6-0.50.60.60.6-0.6-0.60.5-0.50.60.5-0.3
Bone: marrow area3.06.58.32.62.72.6-2.7-2.72.6-2.62.62.6-2.62.6-2.5-2.5-2.62.52.5-2.72.9-2.9-1.81.6
Bone: maximum diameter1.22.23.01.71.71.6-1.7-1.51.5-1.41.51.5-1.51.5-1.4-1.4-1.41.41.4-1.51.6-1.7-1.00.7
Bone: maximum force0.30.50.80.70.70.9-0.7-0.70.8-0.80.70.7-0.70.7-0.8-0.8-0.80.80.8-0.60.7-0.6-0.60.7
Bone: maximum moment0.20.40.50.60.60.7-0.6-0.60.7-0.60.60.6-0.60.6-0.7-0.7-0.70.70.7-0.50.6-0.6-0.40.5
Mean time between licks in bursts0.00.00.1-0.2-0.2-0.00.20.2-0.20.1-0.2-0.20.2-0.20.00.00.1-0.00.00.1-0.10.2-0.00.2
Mean num. licks in bursts0.71.01.3-0.7-0.8-1.10.81.1-1.11.0-1.0-1.01.0-1.11.11.11.0-1.1-1.11.1-1.11.00.8-1.1
Cd content in liver1.41.62.3-1.5-1.4-1.31.31.2-1.41.2-1.4-1.41.4-1.11.31.31.3-1.3-1.31.0-0.90.81.5-1.2
Co content in liver0.00.00.1-0.2-0.1-0.10.10.0-0.1-0.0-0.0-0.00.00.00.10.10.1-0.1-0.1-0.20.1-0.00.3-0.1
Cu content in liver0.60.81.30.80.90.8-0.9-1.00.8-0.90.90.9-0.90.9-0.8-0.8-0.80.80.8-1.11.1-1.1-0.40.5
Fe content in liver0.00.00.20.40.40.0-0.4-0.20.2-0.10.10.1-0.10.1-0.0-0.0-0.10.00.0-0.30.2-0.40.2-0.3
K content in liver0.30.30.50.60.60.6-0.6-0.60.5-0.60.50.5-0.50.5-0.6-0.6-0.60.60.6-0.70.7-0.6-0.40.6
Mg content in liver0.20.20.20.40.40.4-0.4-0.40.3-0.40.40.4-0.40.4-0.4-0.4-0.40.40.4-0.50.5-0.4-0.10.4
Mn content in liver0.60.71.70.30.41.0-0.4-0.80.9-0.90.80.8-0.80.8-1.0-1.0-0.91.01.0-0.50.6-0.5-1.01.3
Na content in liver1.01.11.61.31.11.1-1.1-0.91.1-1.01.01.0-1.00.9-1.1-1.1-1.11.11.1-0.80.8-0.8-1.11.1
Rb content in liver0.30.40.70.30.40.6-0.5-0.70.6-0.70.60.6-0.60.7-0.6-0.6-0.60.60.6-0.80.8-0.7-0.30.6
Se content in liver0.10.10.1-0.3-0.3-0.30.30.2-0.20.3-0.2-0.20.2-0.30.30.30.2-0.3-0.30.1-0.20.20.2-0.3
Sr content in liver0.60.51.20.90.90.7-0.9-0.70.7-0.70.70.7-0.70.8-0.6-0.6-0.60.60.6-0.70.8-1.1-0.30.0
Zn content in liver0.60.71.00.70.80.8-0.8-0.90.8-0.80.80.8-0.80.9-0.8-0.8-0.80.80.8-1.01.0-0.9-0.60.7
Bone: minimum diameter1.83.34.01.91.91.9-1.9-1.91.9-1.91.91.9-1.91.9-1.8-1.8-1.91.81.8-1.81.9-2.0-1.41.1
Time in familiar zone, hab. session 11.61.51.91.41.31.3-1.3-1.21.2-1.31.21.2-1.21.2-1.3-1.3-1.31.31.3-1.11.2-1.2-1.11.1
Time in novel zone, hab. session 10.00.00.10.10.10.1-0.1-0.20.2-0.10.20.3-0.30.2-0.1-0.1-0.10.10.0-0.10.1-0.1-0.30.1
Total zone transitions, hab. session 13.44.76.31.71.82.4-1.7-2.12.4-2.32.32.3-2.32.3-2.3-2.3-2.32.32.3-1.91.7-1.7-2.32.5
Total locomotion distance, hab. session 11.92.73.51.51.51.8-1.4-1.61.9-1.71.81.8-1.81.7-1.7-1.7-1.71.71.7-1.31.3-1.2-1.81.8
Locomotion velocity, hab. session 10.70.91.40.80.81.1-0.7-0.91.1-1.01.11.0-1.01.0-1.0-1.0-1.01.01.0-0.80.8-0.7-1.01.2
Time in familiar zone, hab. session 20.00.00.20.20.10.1-0.1-0.00.0-0.20.00.0-0.00.0-0.3-0.3-0.20.30.3-0.10.1-0.00.10.4
Time in novel zone, hab. session 20.10.10.30.30.30.4-0.3-0.50.4-0.40.50.5-0.50.5-0.3-0.3-0.30.20.2-0.40.4-0.4-0.50.1
Total zone transitions, hab. session 20.40.50.70.80.80.8-0.8-0.70.8-0.70.60.7-0.70.7-0.6-0.6-0.60.60.6-0.80.7-0.8-0.50.4
Total locomotion distance, hab. session 20.10.10.40.60.60.3-0.6-0.40.4-0.30.30.3-0.30.3-0.2-0.2-0.30.20.2-0.50.5-0.6-0.10.0
Locomotion velocity, hab. session 20.00.00.10.30.3-0.0-0.3-0.00.00.0-0.0-0.00.00.00.10.10.1-0.1-0.1-0.20.1-0.30.3-0.3
Novel to familiar place preference ratio0.91.01.51.01.01.0-0.9-1.11.0-1.11.11.1-1.11.0-1.0-1.0-1.11.01.0-0.90.9-0.9-1.20.8
Novelty place preference1.11.21.51.11.11.0-1.0-1.11.1-1.11.11.2-1.21.1-1.1-1.1-1.11.11.1-1.01.0-0.9-1.20.9
Time in novel zone, NPP test0.60.71.00.80.80.8-0.8-0.90.8-0.90.90.9-0.90.9-0.8-0.8-0.90.80.8-0.70.8-0.7-1.00.6
Total zone transitions, NPP test0.00.10.1-0.3-0.3-0.10.30.3-0.10.2-0.3-0.30.3-0.20.10.10.2-0.1-0.10.3-0.40.30.10.2
Total locomotion distance, NPP test0.20.30.4-0.5-0.4-0.50.40.5-0.50.5-0.6-0.50.5-0.50.60.60.6-0.6-0.60.4-0.50.40.5-0.4
Locomotion velocity, NPP test0.00.00.1-0.1-0.1-0.20.10.2-0.20.2-0.3-0.20.2-0.20.30.30.2-0.3-0.30.2-0.30.20.2-0.1
Intraocular pressure1.62.32.91.31.31.6-1.3-1.51.5-1.61.51.5-1.51.5-1.6-1.6-1.61.61.6-1.31.4-1.3-1.71.7
Delta distance traveled before/after self-admin0.10.10.30.20.30.3-0.3-0.40.3-0.30.40.4-0.40.4-0.2-0.2-0.50.20.2-0.30.4-0.3-0.6-0.0
Delta ambulatory time before/after self-admin0.00.00.10.00.10.0-0.1-0.10.0-0.00.20.1-0.10.10.00.0-0.2-0.1-0.1-0.10.1-0.1-0.2-0.3
Parametrial fat weight0.10.10.40.00.10.3-0.1-0.40.4-0.40.50.5-0.50.5-0.3-0.3-0.10.30.3-0.30.2-0.3-0.30.6
Pavlov. Cond. lever latency0.60.81.11.01.00.8-1.1-1.00.9-0.90.91.0-1.00.9-0.8-0.8-0.90.80.8-1.00.9-1.0-0.40.8
Pavlov. Cond. magazine entry latency0.10.10.2-0.4-0.4-0.10.40.4-0.20.3-0.3-0.40.4-0.40.20.10.3-0.1-0.10.3-0.30.50.10.0
Pavlov. Cond. change in total contacts0.10.10.3-0.4-0.4-0.20.50.4-0.40.3-0.3-0.40.4-0.40.20.20.3-0.2-0.20.4-0.30.5-0.1-0.2
Pavlov. Cond. index score0.10.10.2-0.4-0.4-0.20.40.4-0.30.3-0.3-0.50.5-0.40.20.20.3-0.2-0.20.3-0.20.4-0.0-0.2
Pavlov. Cond. latency score0.20.30.5-0.6-0.6-0.40.60.6-0.50.5-0.6-0.70.7-0.60.40.40.5-0.4-0.40.5-0.40.60.2-0.5
Pavlov. Cond. lever contacts0.00.00.1-0.2-0.2-0.00.20.2-0.10.1-0.1-0.30.3-0.20.00.00.1-0.0-0.00.1-0.00.2-0.3-0.2
Pavlov. Cond. magazine entry number0.10.20.40.60.60.3-0.6-0.50.4-0.40.40.5-0.50.5-0.3-0.3-0.40.30.3-0.40.4-0.6-0.10.2
Pavlov. Cond. intertrial magazine entries1.61.92.4-1.3-1.3-1.51.31.3-1.51.4-1.4-1.31.3-1.31.51.51.4-1.5-1.51.2-1.21.11.3-1.5
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.2-0.20.10.20.2-0.10.0-0.1-0.30.3-0.1-0.1-0.10.00.10.10.1-0.00.3-0.30.1
Pavlov. Cond. response bias0.20.20.5-0.6-0.6-0.30.70.6-0.40.4-0.4-0.60.6-0.50.30.30.4-0.3-0.30.6-0.50.7-0.1-0.2
Pavlov. Cond. lever latency2.02.74.8-2.2-2.0-1.72.01.5-1.61.6-1.5-1.51.5-1.51.61.61.6-1.7-1.71.6-1.61.81.3-1.0
Pavlov. Cond. magazine entry latency0.70.81.01.00.91.0-0.9-0.91.0-0.91.01.0-1.00.8-0.9-0.9-0.90.90.9-0.80.8-0.9-0.90.6
Pavlov. Cond. change in total contacts3.25.28.02.82.72.4-2.6-2.22.3-2.22.12.1-2.12.1-2.3-2.3-2.22.32.3-2.32.3-2.5-1.61.5
Pavlov. Cond. index score3.14.26.32.52.42.1-2.4-2.02.1-2.01.91.9-1.91.9-2.1-2.1-2.02.12.1-2.12.1-2.2-1.61.4
Pavlov. Cond. latency score1.92.54.22.01.91.7-1.9-1.51.6-1.51.51.5-1.51.4-1.6-1.6-1.51.61.6-1.51.5-1.7-1.21.0
Pavlov. Cond. lever contacts2.63.65.72.42.22.0-2.2-1.81.8-1.81.71.7-1.71.7-1.9-1.9-1.92.02.0-1.91.9-2.0-1.61.4
Pavlov. Cond. magazine entry number1.21.52.2-1.5-1.4-1.31.41.2-1.31.1-1.2-1.21.2-1.11.21.21.2-1.2-1.21.2-1.21.31.0-0.6
Pavlov. Cond. intertrial magazine entries0.60.91.7-0.6-0.6-1.20.50.9-0.91.0-0.9-0.90.9-0.81.11.11.0-1.1-1.10.7-0.70.51.1-1.3
Pavlov. Cond. lever-magazine prob. diff.3.85.07.32.72.62.3-2.5-2.22.3-2.22.12.1-2.12.1-2.2-2.2-2.22.32.3-2.32.3-2.4-1.81.5
Pavlov. Cond. response bias2.43.34.82.22.11.9-2.0-1.81.8-1.71.71.7-1.71.7-1.8-1.8-1.81.81.8-1.81.8-1.9-1.51.3
Time in closed arm before self-admin0.60.71.31.01.00.8-1.1-0.90.8-0.90.80.8-0.80.9-0.7-0.7-0.70.70.7-1.00.9-1.0-0.50.2
Time in closed arm after self-admin0.40.41.10.90.80.7-0.9-0.50.6-0.50.60.6-0.60.5-0.7-0.7-0.80.70.7-0.40.4-0.3-1.00.4
Time in open arm before self-admin2.12.32.7-1.5-1.5-1.51.51.6-1.41.6-1.5-1.51.5-1.71.51.51.5-1.5-1.51.6-1.61.71.3-1.6
Time in open arm after self-admin0.50.50.9-0.8-0.8-0.60.90.8-0.50.6-0.8-0.80.8-0.70.70.70.7-0.7-0.70.6-0.70.60.9-0.4
Bone: periosteal estimation3.26.88.02.72.72.7-2.7-2.72.7-2.62.72.6-2.62.7-2.6-2.6-2.62.62.5-2.62.8-2.8-2.01.8
Bone: periosteal perimeter2.33.94.72.12.12.1-2.1-2.12.0-2.02.02.0-2.02.0-1.9-1.9-2.01.91.9-1.92.1-2.2-1.51.3
Bone: post-yield work0.60.91.1-1.0-1.0-1.00.91.0-1.01.0-1.0-1.01.0-1.01.01.01.0-0.9-0.90.9-0.91.10.7-0.7
Progressive ratio test 1 active lever presses0.00.00.1-0.3-0.3-0.30.20.1-0.10.10.1-0.10.10.00.20.2-0.2-0.2-0.20.1-0.10.1-0.20.1
Progressive ratio test 1 breakpoint0.00.00.1-0.3-0.2-0.20.20.0-0.10.10.1-0.00.00.10.20.2-0.2-0.2-0.20.1-0.10.1-0.20.1
Progressive ratio test 1 inactive lever presses0.00.10.30.20.30.2-0.3-0.10.2-0.10.1-0.00.00.2-0.0-0.0-0.1-0.0-0.0-0.30.5-0.60.3-0.5
Progressive ratio test 2 active lever presses0.50.61.5-1.2-1.1-0.81.10.6-0.70.7-0.5-0.70.7-0.50.80.80.7-0.8-0.80.6-0.40.40.6-0.8
Progressive ratio test 2 breakpoint0.60.71.4-1.2-1.1-0.81.00.6-0.80.8-0.6-0.80.8-0.50.90.90.8-0.9-0.90.6-0.40.40.7-1.0
Progressive ratio test 2 inactive lever presses0.00.10.2-0.4-0.4-0.10.40.3-0.10.2-0.1-0.30.3-0.20.20.20.1-0.2-0.20.1-0.20.10.2-0.2
Incentive Sensitization - Responses0.20.31.1-1.1-0.9-0.31.00.3-0.20.4-0.2-0.30.3-0.30.40.40.6-0.5-0.50.5-0.20.20.3-0.9
Incentive Sensitization - Breakpoint0.30.41.3-1.2-1.0-0.41.00.4-0.30.5-0.3-0.40.4-0.40.50.50.7-0.6-0.60.5-0.30.30.4-0.9
Sum of active levers in priming session hrs 5-61.11.02.4-1.1-1.2-0.81.41.1-0.71.0-1.0-0.90.9-1.20.70.70.9-0.7-0.71.5-1.41.60.10.1
Progressive ratio1.11.72.41.21.21.4-1.1-1.21.3-1.41.21.2-1.21.2-1.5-1.5-1.41.51.5-1.21.3-1.2-1.41.5
Food seeking constrained by brief footshock1.92.32.91.61.61.5-1.4-1.51.5-1.51.61.6-1.61.5-1.6-1.6-1.71.61.6-1.31.3-1.2-1.71.7
Seeking ratio, punishment vs. effort0.10.10.7-0.2-0.2-0.40.20.2-0.30.4-0.1-0.10.1-0.20.50.50.4-0.6-0.60.3-0.30.30.4-0.8
Retroperitoneal fat weight0.10.40.9-0.6-0.8-0.30.80.8-0.40.4-0.6-0.70.7-0.60.20.20.9-0.2-0.20.8-0.90.9-0.10.5
Reaction time number correct1.01.92.4-1.0-1.2-1.41.21.5-1.51.5-1.5-1.51.5-1.51.31.31.4-1.3-1.31.5-1.51.41.3-1.0
Reaction time mean minus median0.10.10.40.30.50.4-0.6-0.40.5-0.30.40.3-0.30.3-0.2-0.2-0.30.20.2-0.60.5-0.4-0.1-0.0
Reaction time mean minus median AUC0.30.81.31.01.11.0-1.1-0.91.0-0.80.90.8-0.80.9-0.8-0.8-0.80.80.8-1.11.0-1.0-0.60.6
Reaction time num false alarms0.00.10.20.10.10.30.0-0.30.4-0.30.40.3-0.30.2-0.2-0.2-0.20.20.2-0.20.2-0.2-0.2-0.2
Reaction time num false alarms AUC0.10.10.20.10.10.3-0.1-0.30.5-0.30.40.3-0.30.4-0.1-0.1-0.20.10.1-0.40.4-0.4-0.0-0.3
Reaction time trials correct on left1.01.92.4-1.0-1.2-1.41.21.5-1.51.5-1.5-1.51.5-1.51.31.31.4-1.3-1.31.5-1.51.41.3-1.0
Reaction time trials on left1.01.82.3-1.0-1.1-1.31.21.5-1.51.5-1.5-1.51.5-1.51.31.31.4-1.3-1.31.5-1.51.41.3-1.0
Reaction time mean0.61.01.81.21.31.1-1.3-1.11.0-0.91.21.1-1.11.0-0.8-0.8-0.90.80.8-1.31.1-1.1-0.50.3
Reaction time mean AUC0.30.51.00.91.00.7-1.0-0.70.7-0.60.80.7-0.70.7-0.5-0.5-0.60.40.4-0.90.8-0.8-0.20.1
Median of all reaction times0.60.81.51.21.20.9-1.2-1.00.9-0.91.00.9-0.90.9-0.7-0.7-0.80.70.7-1.11.0-1.0-0.40.2
Reaction time omissions0.00.00.1-0.3-0.1-0.10.1-0.0-0.00.0-0.1-0.10.10.00.20.20.2-0.2-0.2-0.20.2-0.10.4-0.2
Reaction time false alarm rate0.30.40.70.40.50.7-0.4-0.80.9-0.70.80.7-0.70.8-0.5-0.5-0.60.50.5-0.80.8-0.8-0.40.0
Reaction time premature initiation rate2.02.83.61.21.41.8-1.3-1.71.9-1.81.71.7-1.71.7-1.8-1.8-1.81.81.8-1.61.7-1.5-1.81.5
Reaction time premature initiations0.51.01.30.70.81.1-0.7-1.01.1-1.11.01.0-1.01.0-1.1-1.1-1.11.11.1-0.80.9-0.8-1.10.9
Std. dev. reaction times0.61.21.71.11.31.2-1.3-1.11.3-1.01.21.1-1.11.1-0.9-0.9-1.00.90.9-1.31.2-1.1-0.80.5
Reaction time trials completed1.01.82.3-1.0-1.1-1.31.21.5-1.51.5-1.5-1.51.5-1.51.31.31.4-1.3-1.31.5-1.51.41.3-1.0
Reaction time trials AUC0.81.52.0-0.9-1.0-1.21.11.4-1.41.3-1.3-1.41.4-1.41.21.21.2-1.1-1.11.4-1.41.31.2-0.9
Run reversals in cocaine runway, females0.00.00.1-0.1-0.20.20.20.20.10.1-0.2-0.20.2-0.2-0.1-0.10.20.10.10.2-0.20.3-0.10.2
Run reversals in cocaine runway, males0.20.20.90.40.30.1-0.5-0.40.4-0.30.40.4-0.40.4-0.4-0.4-0.70.40.4-0.10.2-0.1-1.00.5
Latency to leave start box in cocaine runway1.31.52.41.51.51.2-1.6-1.21.4-1.21.11.1-1.11.3-1.1-1.1-1.11.01.0-1.51.3-1.5-0.40.4
Latency to leave start box in cocaine runway, F0.30.41.10.80.90.5-1.0-0.60.5-0.50.40.4-0.40.7-0.3-0.3-0.50.30.3-1.00.8-1.00.2-0.3
Latency to leave start box in cocaine runway, M2.32.13.31.61.51.5-1.3-1.41.8-1.51.51.6-1.61.4-1.5-1.5-1.41.51.5-1.31.1-1.2-1.31.3
Std. dev. time between licks in bursts0.10.10.4-0.5-0.5-0.00.60.3-0.20.1-0.1-0.10.1-0.2-0.0-0.00.10.00.00.4-0.50.6-0.30.6
Total sessions with >9 infusions0.10.10.50.30.20.3-0.3-0.20.2-0.30.40.2-0.20.3-0.4-0.4-0.40.40.4-0.20.2-0.2-0.50.7
Short access day 1 total inactive lever presses1.01.32.0-0.5-0.7-1.30.61.3-1.31.2-1.4-1.41.4-1.21.11.10.9-1.1-1.11.0-1.00.91.2-1.2
Short access day 10 total inactive lever presses0.30.81.2-0.4-0.6-0.80.71.0-0.70.9-1.0-1.11.1-1.00.80.81.0-0.8-0.80.8-0.90.81.0-0.9
Short access day 1 total infusions0.30.40.7-0.7-0.7-0.80.60.7-0.80.7-0.5-0.70.7-0.60.60.60.5-0.6-0.60.6-0.70.70.5-0.1
Short access day 10 total infusions0.00.00.20.20.10.0-0.1-0.10.0-0.00.20.0-0.00.1-0.1-0.1-0.20.10.1-0.10.1-0.1-0.10.4
Short access total infusions0.00.00.3-0.1-0.1-0.10.10.2-0.10.1-0.0-0.20.2-0.1-0.0-0.0-0.10.10.10.1-0.20.2-0.00.6
Short access day 1 locomotion0.10.10.50.60.60.3-0.7-0.30.2-0.20.30.1-0.10.3-0.2-0.2-0.20.20.2-0.60.4-0.50.3-0.2
Short access day 10 total locomotion0.10.20.50.70.70.3-0.7-0.40.3-0.50.30.4-0.40.4-0.4-0.4-0.30.40.4-0.70.4-0.50.10.2
Short access total locomotion0.10.10.30.40.40.1-0.4-0.10.0-0.20.10.0-0.00.1-0.1-0.1-0.10.10.1-0.50.2-0.40.50.0
One hour access (0.3 mA shock)0.60.70.9-0.7-0.8-0.80.90.9-0.70.8-0.7-0.90.9-0.80.80.80.9-0.8-0.80.8-0.80.70.9-0.9
Compulsive drug intake0.10.20.40.60.60.5-0.6-0.30.4-0.40.10.1-0.10.2-0.4-0.4-0.30.40.4-0.50.5-0.50.1-0.0
One hour access (shock baseline)1.42.22.7-1.5-1.6-1.51.61.5-1.41.5-1.2-1.41.4-1.41.51.51.5-1.5-1.51.5-1.61.51.3-1.1
Social response proportion0.10.10.60.70.70.1-0.8-0.30.1-0.20.30.3-0.30.2-0.0-0.0-0.10.0-0.0-0.50.4-0.6-0.0-0.4
Social responses2.12.73.91.91.71.7-1.7-1.61.7-1.61.71.7-1.71.5-1.7-1.7-1.71.71.7-1.21.3-1.2-2.01.4
Social time0.00.10.10.10.2-0.3-0.20.2-0.30.3-0.2-0.30.3-0.30.30.30.3-0.3-0.3-0.0-0.10.00.3-0.2
Soleus weight1.44.04.7-2.0-2.0-2.02.02.1-2.02.0-2.1-2.12.1-2.02.02.02.0-2.0-2.02.2-2.12.11.5-1.8
Bone: stiffness0.81.31.4-1.2-1.2-1.01.11.2-1.11.1-1.2-1.21.2-1.11.11.11.1-1.1-1.11.1-1.11.11.1-1.1
Tibialis anterior weight0.31.11.5-1.0-1.0-1.01.11.2-1.01.0-1.1-1.21.2-1.11.01.01.0-0.9-0.91.2-1.21.10.8-0.9
Time to tail flick, vehicle, before self-admin2.52.63.4-1.8-1.8-1.51.81.7-1.41.6-1.6-1.61.6-1.51.51.51.8-1.5-1.51.8-1.71.61.3-1.6
Time to tail flick, vehicle, after self-admin1.41.93.21.51.41.5-1.3-1.11.5-1.31.31.1-1.11.1-1.6-1.6-1.31.61.6-0.90.9-0.8-1.61.8
Time to tail flick, test, before self-admin1.01.12.21.11.10.9-1.2-1.10.8-1.11.11.0-1.01.2-0.8-0.8-0.90.80.8-1.31.4-1.5-0.40.4
Time to tail flick, test, after self-admin1.11.11.8-1.4-1.2-1.21.10.7-1.01.1-0.6-0.70.7-0.81.31.31.1-1.3-1.31.1-0.80.80.9-1.3
Delta time to tail flick, vehicle, before/after SA2.52.43.81.71.61.6-1.5-1.41.5-1.51.61.5-1.51.4-1.6-1.6-1.71.71.7-1.31.3-1.2-1.71.9
Delta time to tail flick, test, before/after SA1.91.93.0-1.7-1.7-1.31.71.3-1.21.4-1.1-1.11.1-1.41.41.41.3-1.3-1.31.7-1.71.70.8-0.9
Tibia length0.10.30.6-0.6-0.6-0.40.70.6-0.40.5-0.4-0.50.5-0.60.40.40.5-0.4-0.40.8-0.70.60.2-0.1
Ambulatory time before self-admin0.20.31.3-0.4-0.50.30.70.30.30.0-0.1-0.10.1-0.3-0.4-0.4-0.10.40.40.8-0.70.9-0.71.1
Ambulatory time after self-admin0.30.31.50.1-0.00.60.1-0.40.5-0.40.70.6-0.60.3-0.6-0.6-0.70.60.60.2-0.10.2-1.20.9
Bone: tissue strength3.33.34.4-2.1-2.1-1.82.01.9-1.81.8-1.9-1.91.9-1.91.71.71.8-1.7-1.71.9-1.91.91.8-1.1
Total heroin consumption0.70.81.4-0.9-1.0-0.91.01.0-0.71.0-0.9-0.90.9-1.00.80.81.0-0.8-0.81.2-1.11.10.7-0.5
Bone: trabecular number0.10.20.30.00.10.5-0.1-0.40.5-0.40.50.4-0.40.4-0.4-0.4-0.40.40.4-0.30.4-0.2-0.60.5
Bone: trabecular spacing0.00.00.10.20.10.1-0.1-0.10.1-0.20.10.1-0.10.2-0.2-0.2-0.20.20.2-0.0-0.0-0.1-0.10.4
Bone: trabecular thickness0.81.01.50.90.91.2-0.9-1.01.1-1.01.01.0-1.00.9-1.1-1.1-1.11.11.1-0.91.0-0.8-1.20.9
Bone: trabecular tissue density0.20.20.5-0.2-0.3-0.50.30.5-0.60.5-0.6-0.60.6-0.50.50.50.5-0.5-0.50.5-0.40.40.3-0.7
Water consumed over 24 hours1.62.12.7-1.1-1.2-1.41.21.5-1.41.6-1.6-1.61.6-1.61.51.51.5-1.4-1.41.4-1.41.41.4-1.3
Number of responses in last shaping day0.00.00.30.20.2-0.1-0.30.1-0.20.2-0.1-0.10.1-0.10.10.10.1-0.1-0.1-0.10.0-0.10.4-0.5