Ptprh

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr1_78301495_78305572	0.05	0.04	3.5e-06	0.04	0.05	0.02	0.04	3.1e-05	7.7e-06	1.1e-03	7.3e-05
2	Adipose	gene expression	Ptprh	0.03	0.03	4.4e-04	0	0.01	0.01	0.01	1.1e-01	1.5e-02	4.7e-02	6.2e-02
3	Eye	gene expression	Ptprh	0.55	0.2	1.9e-05	0.07	0.05	-0.02	0.07	2.8e-02	5.8e-02	9.2e-01	3.5e-02
4	Liver	intron excision ratio	chr1_78291059_78294314	0.02	0.02	9.3e-03	0	0	0.01	0	7.4e-02	2.1e-01	2.1e-02	1.7e-01
5	Liver	intron excision ratio	chr1_78294580_78297663	0.06	0.05	4.0e-05	0.03	0.04	0.02	0.03	3.2e-04	7.5e-05	6.1e-03	3.6e-04
6	Liver	gene expression	Ptprh	0.1	0.07	5.7e-07	0.05	0.06	0.05	0.05	5.7e-06	4.1e-07	1.8e-06	1.7e-06
7	Liver	mRNA stability	Ptprh	0.06	0.04	5.6e-04	0.02	0.02	0.02	0.02	4.3e-03	1.3e-03	2.8e-03	1.2e-03
8	Liver	intron excision ratio	chr1_78277081_78280336	0.2	0.11	3.8e-12	0.06	0.1	0.1	0.09	2.0e-07	5.5e-11	1.0e-10	4.3e-10
9	Liver	intron excision ratio	chr1_78287494_78290793	0.07	0.05	1.8e-05	0.04	0.03	0.03	0.03	7.1e-05	1.5e-04	1.2e-04	1.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.1	0.1	0.3	-0.3	0.4	-0.6	-0.3	-0.4	0.4	0.0	-0.3	-0.1
Area under the delay curve	0.3	0.3	0.6	0.6	-0.6	0.8	0.7	0.5	-0.5	0.7	0.1	0.3
BMI with tail	0.5	1.7	3.6	1.4	-1.4	1.5	1.9	1.4	-1.4	0.6	0.9	-0.2
BMI without tail	0.1	0.3	1.1	-0.4	0.2	-0.4	0.1	0.2	-0.2	-0.9	0.7	-1.0
Body weight	0.7	3.1	6.9	-2.3	2.0	-2.0	-0.8	-1.0	0.9	-2.6	0.6	-2.2
Weight adjusted by age	0.6	0.9	1.6	-1.0	1.1	-0.8	-0.8	-1.3	1.3	0.1	-1.1	0.4
Bone surface	2.0	3.7	6.1	-2.4	2.3	-2.5	-2.2	-1.7	1.6	-2.0	-0.3	-1.3
Bone volume	1.6	2.9	5.5	-2.1	2.0	-2.3	-1.8	-1.5	1.5	-1.6	-0.3	-1.2
Breakpoint value in progressive ratio session	0.3	0.3	0.6	0.7	-0.7	0.8	0.7	0.5	-0.5	0.2	0.2	0.3
Number of licking bursts	0.0	0.0	0.1	0.3	-0.3	0.3	0.2	0.2	-0.2	0.1	0.0	0.2
Context. condit. distance diff. score	0.2	0.2	0.5	0.3	-0.2	0.6	0.4	-0.1	0.2	0.5	-0.5	0.7
Locomotion velocity, session 1	2.9	3.1	7.9	0.1	0.5	0.2	-1.4	-1.6	1.7	2.3	-2.8	2.6
Locomotion distance, session 1	3.0	3.7	6.2	-1.7	2.0	-1.6	-2.5	-2.4	2.4	0.1	-2.3	1.1
Locomotion velocity, session 2	0.8	0.9	2.6	0.3	0.0	0.1	-0.3	-0.7	0.8	1.5	-1.5	1.6
Locomotion distance, session 2	1.9	2.6	4.9	-1.6	1.8	-1.7	-2.2	-1.9	1.9	-0.1	-1.6	0.5
Locomotion velocity, session 3	0.1	0.1	0.4	0.2	-0.1	-0.0	-0.0	-0.1	0.1	0.5	-0.4	0.6
Locomotion distance, session 3	0.5	0.6	1.1	-0.4	0.6	-0.5	-0.8	-0.9	0.9	0.4	-1.1	0.8
Stereotopy head waving bouts, day 3	0.1	0.2	0.2	0.4	-0.4	0.5	0.4	0.4	-0.4	-0.3	0.4	-0.2
Stereotopy head waving duration, day 3	0.2	0.2	0.5	0.4	-0.4	0.5	0.7	0.5	-0.5	-0.3	0.5	-0.4
Locomotion velocity, session 7	0.2	0.3	0.7	-0.2	0.3	-0.2	-0.3	-0.6	0.6	0.3	-0.8	0.7
Locomotion distance, session 7	0.4	0.5	1.3	-0.1	0.3	-0.0	-0.1	-0.7	0.7	0.9	-1.1	1.0
Stereotopy head waving bouts, day 7	0.2	0.3	1.2	-0.4	0.3	-0.3	-0.1	0.0	-0.1	-1.1	0.5	-0.7
Stereotopy head waving duration, day 7	0.2	0.2	1.0	-0.4	0.3	-0.4	0.2	0.0	-0.0	-1.0	0.5	-0.7
Locomotion velocity, session 8	0.6	0.7	2.0	0.1	0.2	0.1	-0.6	-0.8	0.8	0.9	-1.4	1.4
Locomotion distance, session 8	0.5	0.7	1.6	-0.4	0.6	-0.2	-0.7	-1.0	1.1	0.5	-1.3	1.0
Degree of sensitization distance	0.0	0.0	0.1	-0.0	0.1	0.1	0.3	-0.1	0.1	0.0	-0.1	0.1
Degree of sensitization stereotypy	0.2	0.2	0.6	-0.1	0.0	-0.1	0.2	0.3	-0.3	-0.8	0.6	-0.6
Conditioned locomotion	0.2	0.3	0.8	-0.2	0.3	0.0	0.0	-0.6	0.6	0.3	-0.9	0.8
Cocaine response after cond. corrected	2.2	2.6	4.4	1.4	-1.7	1.1	2.0	2.1	-2.1	0.1	2.0	-1.0
Cocaine response after cond. not corrected	0.4	0.5	1.6	-0.2	-0.1	-0.5	0.2	0.6	-0.6	-0.7	1.1	-1.2
Cocaine response before conditioning	5.8	7.0	12.5	-3.1	3.1	-3.0	-3.5	-2.9	2.8	-1.7	-1.6	-0.3
Saline control response	0.7	0.9	2.6	-0.1	0.4	-0.0	-0.0	-1.1	1.1	0.9	-1.6	1.5
Bone: connectivity density	0.0	0.0	0.1	0.2	-0.2	0.1	0.3	0.2	-0.2	0.3	0.1	0.1
Bone: cortical apparent density	0.4	0.6	1.7	-0.2	0.4	-0.4	-0.3	-0.8	0.8	1.3	-1.1	0.9
Bone: cortical area	0.6	0.9	1.5	-1.2	1.2	-1.1	-1.0	-0.8	0.8	-1.2	-0.1	-0.7
Bone: cortical porosity	0.5	0.6	0.9	0.8	-0.9	0.6	0.8	1.0	-1.0	-0.3	0.7	-0.3
Bone: cortical porosity	0.5	0.5	1.0	0.4	-0.6	0.2	0.4	0.9	-0.9	-0.9	1.0	-0.8
Bone: cortical thickness	0.2	0.3	0.6	0.7	-0.6	0.7	0.4	0.2	-0.2	0.8	-0.4	0.8
Bone: cortical thickness	0.2	0.3	0.6	-0.3	0.5	-0.4	-0.4	-0.7	0.7	0.6	-0.8	0.5
Bone: cortical tissue density	0.4	0.5	1.6	-0.1	0.3	-0.4	-0.2	-0.7	0.7	1.3	-1.0	0.9
Condit. Reinf. active minus inactive responses	0.1	0.2	0.3	0.5	-0.5	0.3	0.3	0.5	-0.5	0.0	0.3	0.1
Condit. Reinf. active-inactive response ratio	1.3	1.4	2.0	1.4	-1.4	1.3	1.4	1.3	-1.3	0.6	0.8	0.2
Condit. Reinf. active responses	0.1	0.1	0.4	-0.3	0.3	-0.4	-0.6	-0.2	0.2	-0.6	-0.0	-0.1
Condit. Reinf. inactive responses	2.6	3.1	6.1	-2.0	2.1	-1.8	-2.5	-1.9	1.9	-1.3	-1.1	-0.3
Incentive salience index mean	0.1	0.1	0.2	-0.3	0.2	-0.4	-0.4	-0.2	0.2	-0.2	-0.1	-0.0
Condit. Reinf. lever presses	0.6	0.8	1.6	-1.1	1.1	-1.2	-1.2	-0.9	0.9	-0.3	-0.5	-0.2
Condit. Reinf. active minus inactive responses	2.7	3.5	5.6	-2.4	2.3	-2.2	-1.9	-2.0	1.9	-1.8	-0.8	-0.6
Condit. Reinf. active-inactive response ratio	3.7	4.3	7.1	-2.7	2.5	-2.7	-2.1	-1.7	1.7	-2.4	-0.2	-1.5
Condit. Reinf. active responses	2.5	3.5	5.1	-2.2	2.3	-1.9	-2.1	-2.2	2.2	-1.4	-1.4	0.2
Condit. Reinf. inactive responses	0.2	0.3	1.0	-0.1	0.3	0.1	-0.6	-0.6	0.6	-0.0	-0.8	1.0
Condit. Reinf. lever presses	0.7	1.0	4.2	-0.9	0.6	-0.6	-0.5	0.1	-0.1	-2.0	1.0	-1.4
Condit. Reinf. lever reinforcers received	3.2	4.4	6.5	-2.5	2.6	-2.2	-2.4	-2.4	2.4	-1.6	-1.5	0.1
Conditioned reinforcement - actives	0.1	0.2	1.0	-0.5	0.3	-0.6	0.2	0.0	-0.1	-0.2	0.6	-1.0
Conditioned reinforcement - inactives	1.5	2.3	3.7	-1.9	1.9	-1.9	-1.7	-1.6	1.6	-0.6	-0.8	-0.5
Conditioned locomotion	0.1	0.1	0.5	-0.3	0.2	-0.4	0.1	0.1	-0.1	-0.4	0.5	-0.7
Patch foraging indifference point 0 sec	0.4	0.7	1.7	0.7	-0.5	0.9	0.9	-0.1	0.1	1.3	-0.8	1.1
Patch foraging indifference point AUC	0.4	0.5	0.9	1.0	-1.0	0.8	0.6	0.8	-0.8	0.7	0.4	0.3
Delay disc. indifference point, 0s delay	0.6	0.7	2.0	-0.0	0.3	0.2	-0.1	-0.9	0.9	1.0	-1.4	1.1
Delay disc. indifference point, 16s delay	1.3	1.4	2.8	0.9	-1.2	0.7	1.0	1.6	-1.6	-0.4	1.7	-0.8
Delay disc. indifference point, 2s delay	0.5	0.6	2.1	0.7	-0.6	0.7	1.0	0.2	-0.2	1.5	-0.4	0.8
Delay disc. indifference point, 24s delay	0.7	0.8	1.4	0.9	-1.0	0.8	1.0	1.2	-1.2	0.0	1.0	-0.3
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	-0.3	0.2	-0.2	-0.0	-0.0	0.0	-0.1	0.2	-0.3
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	0.3	-0.2	0.5	0.3	0.1	-0.1	0.5	-0.2	0.3
Indifference point function ln k	3.6	6.3	9.4	-2.9	3.1	-2.8	-2.8	-3.0	2.9	-1.5	-1.9	-0.2
Indifference point function log k	3.6	6.3	9.4	-2.9	3.1	-2.8	-2.8	-3.0	2.9	-1.5	-1.9	-0.2
Patch foraging total patch changes 0 sec	0.3	0.6	1.6	0.7	-0.5	0.9	0.9	-0.1	0.1	1.3	-0.8	1.0
Patch foraging total patch changes 12 sec	0.3	0.3	0.6	0.6	-0.7	0.6	0.8	0.7	-0.7	0.3	0.5	-0.0
Patch foraging total patch changes 18 sec	0.4	0.6	1.4	0.9	-0.8	1.2	1.0	0.6	-0.6	0.9	0.0	0.5
Patch foraging total patch changes 24 sec	0.2	0.3	1.1	0.0	-0.2	-0.1	0.3	0.6	-0.7	-0.7	1.0	-0.8
Patch foraging total patch changes 6 sec	0.7	1.0	1.7	1.2	-1.2	1.3	1.3	1.0	-1.0	0.9	0.4	0.3
Patch foraging time to switch 0 sec	3.4	6.9	13.4	2.0	-2.5	1.8	2.6	3.4	-3.5	-0.7	3.7	-2.0
Patch foraging water rate 0 sec	0.8	1.8	3.5	-1.0	1.2	-0.7	-1.4	-1.7	1.8	0.4	-1.9	1.1
Patch foraging water rate 12 sec	2.1	4.4	7.6	-1.9	2.2	-1.5	-2.3	-2.7	2.8	0.0	-2.6	1.4
Patch foraging water rate 18 sec	1.3	2.0	3.5	-1.2	1.5	-0.9	-1.6	-1.8	1.9	0.1	-1.8	1.1
Patch foraging water rate 24 sec	1.1	1.5	2.4	-1.1	1.3	-1.0	-1.4	-1.5	1.6	-0.1	-1.4	0.7
Patch foraging water rate 6 sec	4.0	5.8	9.2	-3.0	2.9	-2.9	-2.8	-2.4	2.3	-2.3	-0.8	-0.9
Seeking ratio, delayed vs. immediate footshock	0.8	1.0	2.9	-0.2	0.5	0.2	-0.5	-1.2	1.2	0.8	-1.7	1.3
Distance traveled before self-admin	3.3	4.3	8.9	-1.6	2.0	-1.1	-1.8	-2.8	2.8	0.6	-3.0	1.4
Distance traveled after self-admin	0.9	1.1	3.2	0.4	-0.1	0.9	-0.0	-0.8	0.9	1.1	-1.8	1.8
Extensor digitorum longus weight	0.2	0.8	2.3	-1.0	0.7	-0.8	-0.2	-0.1	0.1	-1.5	0.7	-1.3
Bone: elastic displacement	0.2	0.3	0.8	0.7	-0.5	0.6	0.1	0.1	-0.1	0.5	-0.5	0.9
Bone: elastic work	0.5	0.6	1.0	-0.8	0.9	-0.7	-0.9	-1.0	1.0	-0.1	-0.8	0.2
Bone: endosteal estimation	1.9	4.1	7.3	-2.7	2.4	-2.4	-1.9	-1.5	1.5	-2.5	0.2	-2.0
Bone: endosteal perimeter	1.2	2.6	4.6	-2.1	2.0	-1.8	-1.5	-1.4	1.3	-1.9	-0.1	-1.3
Epididymis fat weight	0.4	1.5	4.2	0.1	-0.5	0.2	0.6	1.3	-1.3	-1.5	2.1	-1.8
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	0.3	-0.3	0.0	-0.1	0.1	-0.1	0.6	-0.0	0.2
Delta time in open arm before/after self-admin	1.5	1.4	2.2	-1.4	1.5	-1.1	-1.3	-1.5	1.5	-0.9	-1.0	0.0
Diff in mean of infusions in LGA sessions	0.4	0.5	1.4	-0.2	0.4	0.0	-0.3	-0.8	0.9	0.8	-1.2	0.9
Delay discount exponential model param	0.2	0.2	0.4	-0.5	0.5	-0.7	-0.6	-0.4	0.4	-0.5	-0.1	-0.2
Extinction: sum of active levers before priming	0.1	0.1	0.4	0.2	-0.1	0.4	0.0	-0.2	0.2	0.3	-0.6	0.7
Active lever presses in extinction session 6	1.1	1.1	3.2	0.3	-0.6	0.1	0.7	1.3	-1.3	-1.0	1.8	-1.3
Bone: final force	1.5	2.3	4.1	-2.0	1.9	-2.0	-1.5	-1.5	1.5	-1.1	-0.4	-0.9
Bone: final moment	1.9	3.0	5.2	-2.3	2.2	-2.3	-1.8	-1.8	1.8	-1.1	-0.7	-0.9
Food consumed during 24 hour testing period	1.1	1.5	2.6	-1.6	1.6	-1.5	-1.3	-1.3	1.2	-1.0	-0.5	-0.7
Glucose	1.2	1.8	3.4	1.6	-1.4	1.8	1.4	0.7	-0.7	1.8	-0.5	1.4
Heart weight	1.0	1.5	2.9	-1.5	1.3	-1.5	-1.1	-0.6	0.5	-1.7	0.6	-1.5
Delay discount hyperbolic model param	0.3	0.3	0.6	-0.6	0.5	-0.8	-0.7	-0.4	0.4	-0.7	-0.1	-0.3
Intermittent access intake day 1-15 change	0.3	0.5	1.1	-1.1	1.0	-0.9	-0.5	-0.7	0.7	-0.7	-0.2	-0.5
Intermittent access intake escalation	0.4	0.9	1.8	-1.3	1.2	-1.1	-0.7	-0.8	0.7	-1.1	0.0	-0.9
Intermittent access intake escalation 2	0.3	0.4	0.8	-0.4	0.6	-0.1	-0.4	-0.8	0.8	0.2	-0.9	0.6
Intermitt. access day 1 inactive lever presses	0.4	1.4	2.5	-1.4	1.3	-1.6	-1.2	-0.7	0.6	-1.5	0.4	-1.2
Intermitt. access day 15 inactive lever presses	1.2	2.5	5.3	-1.9	1.6	-2.3	-1.6	-0.8	0.8	-2.1	0.5	-1.7
Intermitt. access escalation Index	0.4	0.6	2.2	0.7	-0.7	1.0	1.5	0.6	-0.6	0.6	0.2	0.2
Intermittent access day 1 total infusions	0.2	0.4	0.9	-0.8	0.6	-0.8	-0.2	-0.2	0.2	-0.6	0.4	-0.9
Intermittent access day 15 total infusions	0.5	0.8	1.7	-1.2	1.0	-1.0	-0.3	-0.4	0.3	-1.1	0.6	-1.3
Intermittent access terminal intake (last 3 days)	0.4	0.6	1.2	-1.1	0.9	-0.9	-0.4	-0.5	0.4	-0.8	0.3	-1.0
Intermittent access total infusions	0.8	0.9	1.8	-1.4	1.2	-1.3	-0.6	-0.6	0.6	-0.9	0.3	-1.2
Intermittent access day 1 locomotion	0.6	0.8	1.6	-1.3	1.1	-1.2	-0.6	-0.7	0.7	-0.7	0.1	-1.0
Intermittent access day 15 total locomotion	0.8	1.5	2.7	-1.5	1.6	-1.0	-0.8	-1.6	1.6	-0.0	-1.2	-0.0
Intermittent access total locomotion	1.8	2.1	4.3	-2.1	2.0	-1.7	-1.0	-1.6	1.5	-1.0	-0.5	-1.1
Intermittent access standard deviation	0.1	0.3	0.9	0.5	-0.4	0.9	0.9	0.2	-0.2	0.7	-0.1	0.4
Left kidney weight	3.5	16.2	27.1	-5.2	4.9	-4.8	-4.3	-3.6	3.5	-4.4	-0.6	-2.8
Right kidney weight	3.6	16.3	26.3	-5.1	4.7	-4.9	-4.5	-3.1	3.0	-4.9	0.1	-3.4
Cocaine induced anxiety	0.6	0.9	1.4	-1.1	1.1	-1.1	-1.1	-0.9	0.8	-1.2	-0.3	-0.5
Post-drug Anxiety	0.6	0.6	2.3	-0.7	0.5	-0.8	-0.8	-0.1	0.0	-1.5	0.6	-0.9
Baseline Anxiety	0.5	0.6	0.9	0.9	-0.9	0.9	0.8	0.9	-0.9	0.5	0.6	0.2
Tail length	2.2	8.5	13.9	-3.7	3.5	-3.7	-3.1	-2.6	2.5	-3.2	-0.5	-1.8
Length with tail	1.9	8.3	14.5	-3.8	3.4	-3.6	-2.4	-2.1	2.0	-3.8	0.4	-2.7
Length without tail	1.1	3.5	9.3	-2.2	1.7	-1.9	-0.8	-0.4	0.2	-3.1	1.5	-2.8
Times rat made contact with spout	0.2	0.2	0.5	0.3	-0.4	0.3	0.7	0.5	-0.6	-0.3	0.6	-0.4
Lifetime Intake	0.5	0.6	1.2	-1.1	1.0	-1.1	-0.4	-0.5	0.4	-0.6	0.3	-1.0
Liver weight, left	0.7	1.2	1.9	-1.4	1.3	-1.3	-1.1	-0.8	0.8	-1.3	0.0	-1.0
Liver weight, right	0.0	0.0	0.1	-0.1	0.0	0.1	0.0	0.1	-0.1	-0.3	0.2	-0.3
Locomotor activity	0.1	0.2	0.4	0.4	-0.4	0.5	0.4	0.6	-0.6	-0.1	0.6	-0.4
Locomotor testing distance	0.3	0.5	1.2	-0.1	-0.1	-0.0	0.2	0.6	-0.7	-0.9	1.1	-1.1
Locomotor testing rearing	0.3	0.5	1.3	-0.9	0.7	-0.5	-0.4	-0.2	0.2	-1.1	0.5	-1.2
Locomotion in novel chamber	1.0	1.3	2.7	1.3	-1.2	1.6	1.6	0.8	-0.8	1.3	-0.0	0.5
Locomotion in novel chamber post-restriction	0.5	0.9	2.2	0.9	-1.0	1.0	1.5	1.0	-1.0	0.8	0.6	-0.0
Fecal boli incidents, locomotor time 1	0.2	0.3	0.5	-0.7	0.7	-0.4	-0.6	-0.7	0.7	-0.1	-0.4	-0.0
Change in fecal boli incidents, locomotor task	2.1	2.0	3.3	1.8	-1.6	1.7	1.7	1.1	-1.1	1.8	0.0	1.1
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.2	-0.2	-0.0	0.2	0.4	-0.4	-0.0	0.4	-0.2
Bouts of movement, locomotor time 1	1.5	1.7	4.3	-0.7	1.0	-0.2	-1.0	-1.7	1.7	0.8	-2.1	1.3
Total resting periods, locomotor time 1	0.6	0.7	2.0	-0.1	0.4	0.3	-0.5	-0.9	1.0	0.9	-1.4	1.1
Rest time, locomotor task time 1	0.8	0.9	1.7	-1.3	1.2	-1.1	-1.1	-0.9	0.9	-0.8	-0.2	-0.6
Distance moved, locomotor task time 1	0.7	1.0	1.9	1.4	-1.3	1.3	1.2	0.9	-0.9	0.8	0.1	0.7
Vertical activity count, locomotor time 1	1.0	2.3	4.2	1.8	-1.5	2.0	1.4	0.5	-0.4	2.1	-1.0	1.9
Time >=10cm from walls, locomotor time 2	0.5	0.7	1.2	1.0	-1.1	0.6	0.9	1.0	-1.0	0.5	0.7	0.1
Bouts of movement, locomotor time 2	0.0	0.0	0.0	-0.1	0.1	-0.0	-0.1	-0.1	0.1	-0.1	0.0	-0.1
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.2	0.2	-0.0	-0.2	-0.2	0.2	0.1	-0.2	0.1
Rest time, locomotor task time 2	0.2	0.3	0.7	-0.2	0.3	0.1	-0.2	-0.6	0.6	0.6	-0.9	0.6
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.5	-0.4	0.4	0.3	0.3	-0.3	0.1	0.1	0.2
Vertical activity count, locomotor time 2	0.1	0.2	0.5	0.4	-0.3	0.7	0.3	0.1	-0.1	0.6	-0.3	0.5
Light reinforcement 1	0.5	1.3	3.6	0.2	0.2	0.2	0.1	-1.0	1.0	1.6	-1.8	1.9
Light reinforcement 2	1.0	1.6	3.4	1.4	-1.2	1.5	1.4	0.6	-0.5	1.9	-0.6	1.5
Bone: marrow area	1.9	4.2	7.3	-2.7	2.4	-2.4	-1.9	-1.5	1.4	-2.5	0.3	-2.0
Bone: maximum diameter	0.8	1.4	3.6	-1.5	1.3	-1.2	-1.0	-0.6	0.5	-1.9	0.6	-1.4
Bone: maximum force	2.0	3.6	6.4	-2.5	2.3	-2.4	-1.8	-1.6	1.6	-1.9	-0.1	-1.5
Bone: maximum moment	2.4	4.2	7.3	-2.7	2.6	-2.6	-2.0	-1.9	1.8	-1.9	-0.4	-1.4
Mean time between licks in bursts	0.3	0.6	2.0	0.9	-0.6	0.7	0.3	0.0	0.0	1.4	-0.8	1.1
Mean num. licks in bursts	0.1	0.2	0.5	-0.4	0.2	-0.3	0.1	0.1	-0.1	-0.6	0.5	-0.7
Cd content in liver	1.6	1.8	2.8	-1.7	1.7	-1.6	-1.6	-1.5	1.4	-0.9	-0.7	-0.2
Co content in liver	1.5	1.8	3.3	-1.0	1.2	-1.3	-0.9	-1.7	1.7	0.9	-1.8	0.9
Cu content in liver	0.6	0.7	1.6	-1.1	1.0	-1.3	-0.6	-0.7	0.7	-0.7	-0.1	-0.6
Fe content in liver	0.2	0.2	0.5	-0.6	0.6	-0.7	-0.4	-0.4	0.4	-0.4	-0.1	-0.3
K content in liver	0.0	0.0	0.0	0.0	-0.0	-0.2	0.1	0.0	-0.1	-0.1	0.0	0.1
Mg content in liver	0.4	0.4	0.9	0.3	-0.5	0.2	0.7	0.8	-0.8	-0.4	0.9	-0.7
Mn content in liver	0.3	0.3	0.7	0.2	-0.3	-0.0	0.3	0.6	-0.6	-0.8	0.8	-0.7
Na content in liver	2.0	2.2	3.7	1.9	-1.8	1.7	1.8	1.4	-1.4	1.2	0.4	0.8
Rb content in liver	1.8	2.1	4.2	-1.7	1.5	-1.9	-1.5	-0.9	0.8	-2.0	0.3	-1.4
Se content in liver	2.1	2.5	3.8	1.6	-1.8	1.9	1.8	1.9	-1.9	0.2	1.5	-0.3
Sr content in liver	4.3	3.7	8.3	2.3	-1.9	2.4	2.0	0.7	-0.6	2.9	-1.1	2.2
Zn content in liver	1.0	1.1	2.3	0.8	-1.0	0.6	1.0	1.4	-1.4	-0.2	1.5	-0.9
Bone: minimum diameter	2.4	4.3	7.0	-2.6	2.5	-2.4	-2.4	-1.9	1.9	-2.2	-0.5	-1.4
Time in familiar zone, hab. session 1	3.1	3.0	5.4	-2.0	2.2	-1.7	-1.2	-2.3	2.3	0.0	-1.8	0.5
Time in novel zone, hab. session 1	1.8	1.8	3.3	1.8	-1.8	1.5	1.0	1.6	-1.6	0.6	0.8	0.3
Total zone transitions, hab. session 1	2.3	3.1	6.3	-0.9	1.3	-1.0	-2.3	-2.0	2.1	1.2	-2.5	1.8
Total locomotion distance, hab. session 1	1.3	1.8	4.0	-0.4	0.8	-0.4	-1.6	-1.5	1.5	1.2	-2.0	1.6
Locomotion velocity, hab. session 1	0.9	1.3	2.7	-0.4	0.7	-0.4	-1.6	-1.2	1.3	1.0	-1.7	1.3
Time in familiar zone, hab. session 2	2.0	2.1	4.1	-1.9	1.6	-1.7	-1.0	-0.7	0.6	-2.0	0.7	-1.8
Time in novel zone, hab. session 2	1.2	1.2	2.3	1.5	-1.4	1.3	0.9	0.8	-0.7	1.3	-0.2	1.1
Total zone transitions, hab. session 2	2.4	3.1	6.6	-1.7	1.9	-1.5	-2.6	-2.1	2.1	-0.4	-1.7	0.6
Total locomotion distance, hab. session 2	0.6	0.7	1.8	-0.1	0.4	0.0	-1.0	-0.9	0.9	0.9	-1.3	1.2
Locomotion velocity, hab. session 2	0.7	0.9	2.2	-0.0	0.3	0.1	-1.0	-0.9	0.9	1.1	-1.5	1.4
Novel to familiar place preference ratio	0.1	0.1	0.3	-0.1	0.1	-0.0	0.4	0.1	-0.1	-0.5	0.3	-0.4
Novelty place preference	0.1	0.1	0.3	-0.4	0.3	-0.3	0.2	-0.1	0.1	-0.6	0.1	-0.4
Time in novel zone, NPP test	0.1	0.1	0.4	-0.4	0.3	-0.3	0.3	-0.1	0.1	-0.6	0.2	-0.5
Total zone transitions, NPP test	0.6	0.9	2.1	-0.6	0.8	-0.5	-1.5	-1.1	1.1	0.4	-1.2	0.7
Total locomotion distance, NPP test	0.3	0.4	1.4	-0.6	0.7	-0.5	-1.2	-0.6	0.6	-0.4	-0.4	-0.1
Locomotion velocity, NPP test	0.4	0.6	1.9	-0.7	0.8	-0.6	-1.4	-0.9	0.9	-0.2	-0.8	0.3
Intraocular pressure	0.1	0.1	0.3	0.2	-0.1	-0.1	0.2	-0.1	0.1	0.5	-0.4	0.6
Delta distance traveled before/after self-admin	1.7	1.8	2.8	1.6	-1.6	1.7	1.5	1.5	-1.4	0.6	0.7	0.4
Delta ambulatory time before/after self-admin	1.0	1.2	2.0	1.4	-1.4	1.4	1.2	1.1	-1.1	0.7	0.5	0.5
Parametrial fat weight	1.3	3.1	4.9	2.1	-2.1	2.2	2.2	1.9	-1.9	1.1	1.0	0.2
Pavlov. Cond. lever latency	0.1	0.1	0.5	0.3	-0.3	0.1	0.7	0.1	-0.0	0.5	-0.3	0.5
Pavlov. Cond. magazine entry latency	0.6	0.8	1.4	1.0	-1.1	1.0	0.7	1.2	-1.2	0.2	0.9	-0.3
Pavlov. Cond. change in total contacts	0.2	0.2	0.5	0.5	-0.5	0.7	0.3	0.3	-0.3	0.5	0.0	0.3
Pavlov. Cond. index score	0.2	0.2	0.6	0.6	-0.6	0.7	0.2	0.6	-0.6	0.4	0.3	0.0
Pavlov. Cond. latency score	0.2	0.2	0.5	0.5	-0.5	0.7	0.1	0.5	-0.5	0.2	0.4	-0.1
Pavlov. Cond. lever contacts	0.2	0.3	0.9	-0.3	0.2	-0.0	-0.6	0.2	-0.2	-0.8	0.7	-0.9
Pavlov. Cond. magazine entry number	0.2	0.3	0.5	-0.6	0.6	-0.6	-0.4	-0.7	0.7	-0.1	-0.6	0.3
Pavlov. Cond. intertrial magazine entries	1.0	1.2	3.4	0.1	0.3	0.1	-0.4	-1.1	1.1	1.2	-1.8	1.8
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.6	0.6	-0.6	0.8	0.3	0.6	-0.6	0.3	0.4	-0.0
Pavlov. Cond. response bias	0.2	0.3	0.8	0.1	-0.3	0.2	-0.0	0.6	-0.7	-0.5	0.9	-0.8
Pavlov. Cond. lever latency	0.2	0.3	0.5	-0.6	0.6	-0.7	-0.6	-0.5	0.5	0.0	-0.2	-0.2
Pavlov. Cond. magazine entry latency	0.7	0.8	1.2	1.0	-1.1	1.0	1.0	1.1	-1.1	0.1	0.8	-0.2
Pavlov. Cond. change in total contacts	0.1	0.2	0.4	-0.4	0.5	-0.4	0.2	-0.6	0.6	-0.4	-0.6	0.2
Pavlov. Cond. index score	0.1	0.1	0.1	0.3	-0.3	0.2	0.4	0.4	-0.4	-0.4	0.3	-0.3
Pavlov. Cond. latency score	0.3	0.4	0.6	0.7	-0.8	0.6	0.8	0.7	-0.7	-0.1	0.5	-0.2
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.3	-0.3	0.4	0.5	0.3	-0.3	-0.3	0.2	-0.0
Pavlov. Cond. magazine entry number	0.3	0.4	0.7	-0.8	0.8	-0.7	-0.9	-0.7	0.7	-0.3	-0.4	0.1
Pavlov. Cond. intertrial magazine entries	2.2	3.3	5.5	-2.2	2.2	-2.2	-2.3	-1.9	1.8	-1.5	-0.8	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.4	-0.4	0.3	0.4	0.4	-0.3	-0.1	0.2	-0.1
Pavlov. Cond. response bias	0.1	0.1	0.6	-0.3	0.3	-0.4	-0.3	-0.2	0.2	-0.8	0.1	-0.3
Time in closed arm before self-admin	0.5	0.6	1.1	-1.0	1.0	-1.0	-0.7	-0.8	0.7	-0.9	-0.2	-0.4
Time in closed arm after self-admin	0.2	0.2	0.4	-0.2	0.0	-0.5	-0.2	0.3	-0.3	-0.5	0.6	-0.6
Time in open arm before self-admin	1.6	1.7	2.7	1.6	-1.6	1.5	1.4	1.3	-1.3	1.4	0.5	0.5
Time in open arm after self-admin	0.2	0.2	0.4	0.4	-0.2	0.6	0.3	-0.1	0.2	0.6	-0.6	0.7
Bone: periosteal estimation	1.5	3.1	5.5	-2.3	2.2	-2.1	-1.7	-1.5	1.4	-2.1	-0.0	-1.5
Bone: periosteal perimeter	1.3	2.2	3.7	-1.9	1.8	-1.7	-1.5	-1.4	1.3	-1.6	-0.3	-0.9
Bone: post-yield work	2.2	3.2	6.5	-2.2	1.9	-2.2	-1.5	-1.0	0.9	-2.5	0.7	-2.1
Progressive ratio test 1 active lever presses	0.7	0.8	1.5	-1.0	1.1	-0.8	-0.8	-1.2	1.2	0.2	-1.0	0.2
Progressive ratio test 1 breakpoint	0.7	0.8	1.4	-1.0	1.1	-0.8	-0.8	-1.2	1.2	0.2	-1.0	0.2
Progressive ratio test 1 inactive lever presses	1.8	2.6	4.6	-2.0	2.0	-2.1	-1.9	-1.7	1.7	-0.9	-0.7	-0.6
Progressive ratio test 2 active lever presses	0.4	0.5	1.4	-0.8	0.6	-0.8	-0.2	-0.0	-0.0	-0.9	0.7	-1.2
Progressive ratio test 2 breakpoint	0.5	0.6	1.6	-0.9	0.6	-0.9	-0.2	-0.1	-0.0	-1.0	0.8	-1.3
Progressive ratio test 2 inactive lever presses	1.8	2.9	4.9	-2.2	2.1	-2.2	-1.7	-1.6	1.6	-1.4	-0.4	-1.1
Incentive Sensitization - Responses	1.1	1.5	3.8	-1.4	1.0	-1.4	-0.6	-0.2	0.1	-1.9	1.1	-1.8
Incentive Sensitization - Breakpoint	0.9	1.2	3.2	-1.1	0.8	-1.1	-0.3	0.1	-0.2	-1.8	1.2	-1.7
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	0.1	0.1	0.3	0.2	-0.4	0.4	0.2	-0.7	0.7
Progressive ratio	0.2	0.3	0.8	-0.0	0.2	0.0	-0.9	-0.5	0.5	0.2	-0.8	0.8
Food seeking constrained by brief footshock	4.9	6.0	17.3	-0.4	1.1	0.2	-1.5	-2.7	2.9	2.4	-4.2	3.4
Seeking ratio, punishment vs. effort	0.6	0.9	1.7	-0.9	1.0	-0.6	-0.6	-1.3	1.3	0.3	-1.3	0.5
Retroperitoneal fat weight	3.6	15.5	22.6	4.4	-4.7	4.4	4.8	4.7	-4.6	1.7	3.2	-0.3
Reaction time number correct	0.1	0.1	0.3	0.4	-0.3	0.6	0.2	0.1	-0.0	0.4	-0.3	0.6
Reaction time mean minus median	0.0	0.0	0.1	-0.0	0.0	0.0	0.1	-0.0	0.0	0.1	-0.0	-0.3
Reaction time mean minus median AUC	0.0	0.1	0.2	0.1	-0.1	0.1	0.3	0.3	-0.3	-0.1	0.4	-0.5
Reaction time num false alarms	0.0	0.0	0.3	-0.0	0.0	-0.2	0.6	-0.1	0.1	0.2	-0.1	-0.1
Reaction time num false alarms AUC	0.2	0.4	1.1	0.4	-0.2	0.2	0.8	-0.2	0.2	1.0	-0.8	0.7
Reaction time trials correct on left	0.1	0.1	0.3	0.4	-0.3	0.6	0.2	0.1	-0.0	0.4	-0.3	0.6
Reaction time trials on left	0.1	0.1	0.4	0.4	-0.3	0.6	0.2	0.0	0.0	0.5	-0.3	0.6
Reaction time mean	0.4	0.7	1.5	-0.9	0.8	-1.2	-0.6	-0.3	0.3	-1.0	0.4	-1.2
Reaction time mean AUC	0.3	0.4	1.6	-0.5	0.3	-0.8	-0.0	0.1	-0.2	-0.8	0.8	-1.3
Median of all reaction times	0.5	0.7	1.7	-0.9	0.7	-1.3	-0.6	-0.2	0.2	-1.1	0.6	-1.2
Reaction time omissions	0.2	0.3	1.0	0.1	0.1	0.1	0.1	-0.5	0.5	1.0	-1.0	0.8
Reaction time false alarm rate	0.1	0.2	0.6	0.1	-0.0	-0.1	0.6	-0.3	0.3	0.7	-0.6	0.4
Reaction time premature initiation rate	0.1	0.1	0.4	-0.1	0.0	-0.1	0.3	0.2	-0.2	-0.3	0.5	-0.7
Reaction time premature initiations	0.1	0.1	0.3	0.2	-0.3	0.3	0.5	0.4	-0.4	-0.2	0.5	-0.5
Std. dev. reaction times	0.2	0.4	1.2	-0.8	0.6	-0.8	-0.4	-0.2	0.2	-0.8	0.4	-1.1
Reaction time trials completed	0.1	0.1	0.4	0.4	-0.3	0.6	0.2	0.0	0.0	0.5	-0.3	0.6
Reaction time trials AUC	0.0	0.1	0.3	0.4	-0.3	0.6	0.3	0.2	-0.1	0.2	-0.1	0.3
Run reversals in cocaine runway, females	0.4	0.4	0.9	-0.5	0.3	-0.8	-0.2	0.1	-0.2	-0.9	0.7	-0.9
Run reversals in cocaine runway, males	0.1	0.1	0.4	-0.1	0.0	-0.2	0.7	0.1	-0.1	0.1	0.2	-0.4
Latency to leave start box in cocaine runway	0.3	0.4	0.8	-0.8	0.8	-0.9	-0.7	-0.6	0.6	-0.5	-0.2	-0.2
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.3	0.2	-0.3	-0.2	-0.2	0.2	-0.1	-0.1	-0.0
Latency to leave start box in cocaine runway, M	1.0	0.9	1.6	-1.3	1.2	-1.3	-1.0	-0.9	0.8	-1.0	-0.2	-0.6
Std. dev. time between licks in bursts	1.1	1.5	4.2	0.3	0.1	0.1	-0.5	-1.1	1.1	1.6	-2.1	2.0
Total sessions with >9 infusions	0.6	0.8	1.4	-1.1	1.2	-1.0	-0.4	-1.1	1.1	-0.2	-0.7	-0.3
Short access day 1 total inactive lever presses	0.5	0.7	1.7	-0.9	0.7	-1.0	-0.3	-0.1	0.0	-1.2	0.8	-1.3
Short access day 10 total inactive lever presses	0.1	0.1	0.3	-0.5	0.4	-0.4	-0.3	-0.3	0.3	-0.4	0.1	-0.3
Short access day 1 total infusions	0.0	0.0	0.2	-0.1	0.1	-0.1	0.2	-0.1	0.1	0.4	-0.1	-0.0
Short access day 10 total infusions	0.0	0.0	0.3	0.1	-0.1	0.1	0.2	-0.0	0.0	0.6	-0.2	0.1
Short access total infusions	0.1	0.1	0.5	0.2	-0.2	0.2	0.6	0.2	-0.2	0.7	0.0	0.0
Short access day 1 locomotion	0.2	0.3	0.8	-0.7	0.5	-0.7	0.1	-0.2	0.1	-0.4	0.4	-0.9
Short access day 10 total locomotion	0.8	1.5	2.9	-1.1	1.3	-0.7	-0.8	-1.7	1.7	0.5	-1.7	0.7
Short access total locomotion	0.9	1.0	2.6	-0.6	0.9	-0.2	-0.2	-1.3	1.4	1.1	-1.6	0.8
One hour access (0.3 mA shock)	2.5	2.9	5.4	-2.3	2.1	-2.2	-1.4	-1.5	1.4	-1.8	-0.1	-1.5
Compulsive drug intake	1.3	1.6	2.6	-1.6	1.5	-1.4	-1.2	-1.2	1.1	-1.5	-0.3	-0.8
One hour access (shock baseline)	0.3	0.4	1.2	-0.5	0.3	-0.8	-0.2	0.2	-0.3	-0.6	0.9	-1.1
Social response proportion	0.8	0.9	2.0	-0.9	0.7	-1.2	-0.7	-0.0	-0.0	-1.4	0.9	-1.4
Social responses	2.0	2.6	5.4	-2.0	1.9	-2.3	-1.9	-1.3	1.3	-1.7	-0.1	-1.0
Social time	3.5	4.8	8.7	-2.3	2.5	-2.1	-3.0	-2.6	2.6	-0.8	-2.0	0.5
Soleus weight	0.0	0.1	0.2	-0.4	0.3	-0.0	0.3	-0.1	0.0	-0.5	0.3	-0.4
Bone: stiffness	1.7	2.8	5.0	-2.2	2.1	-2.1	-1.6	-1.5	1.4	-1.6	-0.2	-1.3
Tibialis anterior weight	0.9	3.1	5.9	1.6	-1.8	2.1	2.4	2.1	-2.1	0.0	1.8	-0.7
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.2	-0.7	0.9	-0.5	-0.7	-1.1	1.1	0.1	-1.1	0.5
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.9	-0.6	0.4	-0.6	-0.1	0.1	-0.1	-0.9	0.7	-0.9
Time to tail flick, test, before self-admin	1.1	1.1	2.8	0.1	0.2	0.7	0.3	-0.9	1.0	1.6	-1.7	1.5
Time to tail flick, test, after self-admin	0.2	0.2	0.5	0.5	-0.6	0.2	0.4	0.7	-0.7	-0.1	0.6	-0.1
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.5	0.3	-0.5	0.2	0.7	0.9	-1.0	-0.3	1.2	-0.9
Delta time to tail flick, test, before/after SA	0.6	0.6	1.7	-0.1	-0.1	-0.7	-0.4	0.6	-0.7	-1.3	1.2	-1.0
Tibia length	2.4	6.6	11.0	-3.3	3.0	-3.1	-2.6	-2.0	1.9	-3.2	0.1	-2.3
Ambulatory time before self-admin	2.1	3.1	5.8	-1.5	1.8	-1.1	-1.6	-2.4	2.4	0.2	-2.4	1.0
Ambulatory time after self-admin	1.1	1.3	4.1	-0.2	0.6	0.1	-0.7	-1.3	1.4	0.6	-2.0	1.5
Bone: tissue strength	0.9	0.9	2.0	-0.5	0.7	-0.1	-0.6	-1.1	1.2	0.9	-1.4	1.1
Total heroin consumption	0.0	0.1	0.2	0.1	-0.0	0.2	-0.0	-0.2	0.2	0.1	-0.4	0.4
Bone: trabecular number	0.1	0.2	0.6	0.4	-0.4	0.4	0.4	0.1	-0.1	0.7	-0.2	0.4
Bone: trabecular spacing	0.0	0.1	0.1	0.0	-0.1	0.1	0.2	0.2	-0.2	-0.3	0.4	-0.3
Bone: trabecular thickness	0.0	0.0	0.1	-0.1	0.0	-0.3	0.2	0.0	-0.0	0.0	0.1	-0.3
Bone: trabecular tissue density	0.8	1.2	2.1	1.1	-1.2	1.0	1.0	1.4	-1.5	-0.1	1.3	-0.6
Water consumed over 24 hours	0.7	1.0	1.7	-1.1	1.2	-1.0	-1.0	-1.3	1.3	-0.1	-1.0	0.1
Number of responses in last shaping day	0.1	0.1	0.4	0.0	-0.1	-0.3	0.2	0.4	-0.4	-0.0	0.6	-0.6