Ptpra

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Ptpra	0.08	0.06	5.7e-07	0.05	0.06	0.06	0.06	2.1e-06	5.5e-07	7.9e-07	5.5e-07
2	Brain	gene expression	Ptpra	0.12	0.09	3.7e-08	0.07	0.08	0.08	0.08	7.8e-07	8.3e-08	3.9e-08	5.5e-08
3	NAcc	gene expression	Ptpra	0.07	0.05	2.5e-10	0.08	0.08	0.08	0.08	1.1e-09	3.1e-09	3.9e-09	1.0e-09
4	Adipose	intron excision ratio	chr3_117705569_117714664	0.02	0.02	8.3e-03	0.01	0	-0	0	7.1e-02	3.0e-01	5.1e-01	3.6e-01
5	pVTA	gene expression	Ptpra	0.08	0.06	2.5e-04	0.09	0.09	0.1	0.03	9.2e-05	9.8e-05	6.9e-05	1.8e-02
6	PL	mRNA stability	Ptpra	0.02	0.02	3.0e-03	0.02	0.01	0.02	0.02	9.8e-04	8.5e-03	1.4e-03	3.6e-03
7	Liver	gene expression	Ptpra	0.03	0.02	9.3e-04	0.01	0.01	0	0	1.6e-02	5.1e-02	2.2e-01	1.7e-01
8	IL	gene expression	Ptpra	0.2	0.16	9.8e-03	0.01	0.08	0.08	0.06	1.4e-01	5.1e-03	6.7e-03	1.6e-02
9	BLA	gene expression	Ptpra	0.14	0.1	2.8e-04	0.04	0.02	0.06	0.05	5.7e-03	2.3e-02	5.5e-04	9.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.4	0.7	1.8	-1.3	1.3	-0.8	-0.8	0.7	0.7	0.5	0.1	-0.3
Area under the delay curve	0.3	0.3	1.0	0.9	-1.0	0.4	0.4	-0.6	-0.4	-0.4	-0.0	0.2
BMI with tail	1.2	3.8	5.5	-1.8	1.9	-2.0	-2.3	2.0	2.3	1.8	-1.7	1.8
BMI without tail	3.8	7.9	10.7	-2.6	2.8	-2.9	-3.1	2.9	3.3	2.6	-2.5	2.5
Body weight	5.7	24.0	27.2	-4.9	4.9	-5.2	-5.2	5.2	5.1	5.0	-4.3	4.1
Weight adjusted by age	3.2	3.6	5.5	-2.4	2.1	-2.2	-2.0	2.1	1.2	2.3	-1.3	1.2
Bone surface	0.6	1.1	2.4	-1.5	1.6	-1.1	-1.1	1.0	0.9	0.9	-0.3	0.2
Bone volume	0.6	1.0	2.2	-1.5	1.5	-1.0	-1.0	1.0	0.9	0.9	-0.3	0.2
Breakpoint value in progressive ratio session	3.1	3.4	4.9	-1.5	1.5	-1.9	-1.9	1.9	2.2	1.8	-1.9	1.8
Number of licking bursts	0.3	0.3	0.8	0.9	-0.9	0.5	0.6	-0.3	-0.6	-0.5	-0.3	0.3
Context. condit. distance diff. score	0.2	0.2	0.5	-0.7	0.6	-0.2	-0.3	0.2	-0.0	0.3	0.7	-0.7
Locomotion velocity, session 1	0.3	0.3	0.5	-0.7	0.6	-0.6	-0.6	0.6	0.3	0.6	-0.3	0.1
Locomotion distance, session 1	0.5	0.6	1.6	-1.3	1.2	-0.6	-0.7	0.4	0.4	0.5	0.7	-0.9
Locomotion velocity, session 2	0.1	0.1	0.3	0.1	-0.2	0.2	0.2	-0.4	-0.4	-0.4	0.5	-0.5
Locomotion distance, session 2	1.3	1.8	3.6	-1.9	1.9	-1.4	-1.3	1.1	1.5	1.3	-0.1	-0.1
Locomotion velocity, session 3	1.3	1.5	2.4	-1.1	1.2	-1.4	-1.5	1.2	1.1	1.2	-1.1	1.2
Locomotion distance, session 3	6.5	7.1	9.4	-2.6	2.7	-2.9	-3.1	2.7	2.8	2.6	-2.3	2.3
Stereotopy head waving bouts, day 3	1.5	1.7	3.6	0.5	-0.8	1.2	1.5	-1.2	-1.4	-1.0	1.7	-1.9
Stereotopy head waving duration, day 3	0.9	1.1	1.7	0.6	-0.8	1.0	1.3	-1.0	-1.1	-0.8	1.1	-1.3
Locomotion velocity, session 7	0.8	0.9	1.4	-1.2	1.0	-1.0	-1.0	0.9	1.0	1.2	-0.6	0.5
Locomotion distance, session 7	0.6	0.8	1.5	-1.2	1.1	-1.0	-1.0	0.7	1.1	0.9	0.0	-0.0
Stereotopy head waving bouts, day 7	0.4	0.5	0.8	-0.6	0.6	-0.7	-0.5	0.8	0.7	0.8	-0.9	0.8
Stereotopy head waving duration, day 7	0.1	0.2	0.5	-0.2	0.2	-0.3	-0.2	0.5	0.3	0.4	-0.7	0.6
Locomotion velocity, session 8	0.5	0.6	1.6	-1.3	1.2	-0.7	-0.6	0.6	0.4	0.6	0.5	-0.6
Locomotion distance, session 8	2.2	3.2	7.3	-2.7	2.6	-1.8	-1.9	1.5	1.6	1.7	0.2	-0.4
Degree of sensitization distance	2.3	2.3	3.2	1.1	-1.3	1.5	1.6	-1.6	-1.4	-1.3	1.8	-1.8
Degree of sensitization stereotypy	2.5	2.8	4.2	-1.2	1.3	-1.6	-1.5	1.8	1.7	1.6	-2.0	2.0
Conditioned locomotion	3.8	4.5	7.2	-2.7	2.7	-2.2	-2.2	2.1	2.0	2.2	-1.2	1.0
Cocaine response after cond. corrected	0.2	0.2	0.6	0.1	-0.2	0.3	0.3	-0.5	-0.5	-0.4	0.7	-0.8
Cocaine response after cond. not corrected	0.2	0.3	0.5	0.3	-0.4	0.4	0.4	-0.6	-0.6	-0.4	0.6	-0.7
Cocaine response before conditioning	0.1	0.2	0.5	0.6	-0.7	0.4	0.5	-0.4	-0.1	-0.2	0.0	-0.1
Saline control response	6.8	8.9	10.7	-3.2	3.3	-3.1	-3.2	3.2	3.1	3.0	-2.4	2.2
Bone: connectivity density	0.2	0.3	1.0	-1.0	1.0	-0.4	-0.4	0.4	0.5	0.2	0.3	-0.5
Bone: cortical apparent density	0.9	1.1	2.6	-0.3	0.4	-1.0	-0.9	0.9	1.0	1.1	-1.5	1.6
Bone: cortical area	3.2	4.9	6.0	-2.3	2.3	-2.3	-2.4	2.3	2.3	2.2	-1.8	1.7
Bone: cortical porosity	0.5	0.5	2.2	0.4	-0.2	-0.4	-0.7	0.4	0.3	0.4	-1.2	1.5
Bone: cortical porosity	0.9	1.0	3.3	-0.0	0.3	-0.8	-1.1	0.8	0.8	0.8	-1.5	1.8
Bone: cortical thickness	1.5	2.5	3.2	-1.4	1.5	-1.7	-1.8	1.6	1.6	1.6	-1.4	1.5
Bone: cortical thickness	0.3	0.3	0.5	-0.5	0.5	-0.5	-0.6	0.6	0.5	0.5	-0.7	0.7
Bone: cortical tissue density	0.7	0.9	2.2	-0.2	0.3	-0.9	-0.8	0.8	0.9	1.0	-1.4	1.5
Condit. Reinf. active minus inactive responses	0.8	0.9	1.4	-0.6	0.7	-1.0	-1.1	0.9	1.1	0.9	-1.1	1.2
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.1	-0.9	0.9	-0.9	-0.9	0.9	1.1	0.8	-0.7	0.7
Condit. Reinf. active responses	0.6	0.8	1.3	-0.5	0.6	-0.9	-1.0	0.8	0.9	0.8	-1.0	1.1
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.0	0.0	-0.1	-0.1	0.0	0.0	0.1	0.0	-0.0
Incentive salience index mean	0.5	0.6	1.1	-0.5	0.7	-0.8	-1.1	0.7	0.8	0.7	-0.8	0.9
Condit. Reinf. lever presses	0.1	0.2	0.6	-0.1	0.3	-0.4	-0.8	0.3	0.4	0.2	-0.4	0.6
Condit. Reinf. active minus inactive responses	2.1	2.7	4.3	-2.1	1.8	-1.6	-1.3	1.8	2.0	1.8	-1.0	0.6
Condit. Reinf. active-inactive response ratio	2.1	2.2	3.2	-1.8	1.6	-1.5	-1.3	1.6	1.8	1.6	-1.0	0.7
Condit. Reinf. active responses	3.4	4.7	7.5	-2.7	2.5	-2.2	-1.8	2.3	2.6	2.4	-1.4	0.9
Condit. Reinf. inactive responses	0.6	0.8	1.8	-1.3	1.2	-0.9	-0.6	0.9	0.9	1.0	-0.3	0.1
Condit. Reinf. lever presses	1.4	1.9	2.5	-1.3	1.2	-1.4	-1.0	1.5	1.6	1.5	-1.4	1.2
Condit. Reinf. lever reinforcers received	2.6	3.7	6.2	-2.5	2.2	-2.0	-1.5	2.1	2.3	2.1	-1.1	0.7
Conditioned reinforcement - actives	0.0	0.0	0.0	-0.1	0.2	-0.0	0.0	0.1	-0.0	0.1	-0.0	0.0
Conditioned reinforcement - inactives	0.5	0.6	1.8	-1.3	1.2	-0.5	-0.3	0.5	0.8	0.7	0.4	-0.6
Conditioned locomotion	0.1	0.1	0.2	0.2	-0.0	0.4	0.3	-0.3	0.0	-0.4	0.3	-0.3
Patch foraging indifference point 0 sec	0.2	0.4	1.2	-1.1	1.0	-0.3	0.0	0.2	0.2	0.3	0.6	-0.9
Patch foraging indifference point AUC	0.6	0.6	0.9	-0.7	0.8	-0.8	-0.9	0.7	1.0	0.7	-0.8	0.8
Delay disc. indifference point, 0s delay	2.6	2.9	5.4	2.1	-2.3	1.7	1.7	-1.7	-1.4	-1.9	1.0	-1.0
Delay disc. indifference point, 16s delay	0.6	0.6	1.3	1.1	-1.2	0.7	0.6	-0.9	-0.7	-0.7	0.3	-0.1
Delay disc. indifference point, 2s delay	0.0	0.0	0.2	0.2	-0.4	0.2	0.1	-0.1	-0.2	-0.2	-0.0	0.1
Delay disc. indifference point, 24s delay	2.4	2.4	3.6	1.8	-1.9	1.5	1.4	-1.7	-1.8	-1.5	1.0	-0.9
Delay disc. indifference point, 4s delay	0.2	0.2	0.7	0.3	-0.3	-0.2	-0.2	0.1	0.5	0.1	-0.7	0.9
Delay disc. indifference point, 8s delay	0.4	0.4	1.1	1.0	-1.0	0.4	0.5	-0.6	-0.4	-0.4	-0.3	0.5
Indifference point function ln k	0.1	0.1	0.3	-0.6	0.4	-0.3	-0.4	0.2	-0.0	0.3	0.2	-0.3
Indifference point function log k	0.1	0.1	0.3	-0.6	0.4	-0.3	-0.4	0.2	-0.0	0.3	0.2	-0.3
Patch foraging total patch changes 0 sec	0.3	0.4	1.4	-1.2	1.1	-0.3	-0.1	0.3	0.2	0.3	0.7	-0.9
Patch foraging total patch changes 12 sec	0.4	0.5	1.2	-0.9	1.1	-0.7	-0.8	0.6	0.6	0.4	-0.4	0.5
Patch foraging total patch changes 18 sec	0.8	1.0	1.8	0.4	-0.5	1.0	1.0	-1.0	-0.9	-0.9	1.3	-1.3
Patch foraging total patch changes 24 sec	1.7	2.1	3.7	0.7	-0.8	1.5	1.5	-1.5	-1.4	-1.6	1.8	-1.9
Patch foraging total patch changes 6 sec	0.7	1.0	2.6	-1.5	1.6	-0.7	-0.6	0.8	1.1	0.8	0.3	-0.4
Patch foraging time to switch 0 sec	1.8	2.7	5.9	2.4	-2.0	1.7	1.6	-1.7	-1.7	-1.7	0.6	-0.2
Patch foraging water rate 0 sec	3.6	5.7	12.1	-3.5	3.1	-2.4	-2.2	2.6	2.4	2.4	-0.9	0.4
Patch foraging water rate 12 sec	0.1	0.2	0.6	-0.8	0.4	-0.2	0.0	0.1	-0.3	0.3	0.5	-0.7
Patch foraging water rate 18 sec	0.3	0.4	0.7	-0.8	0.8	-0.6	-0.6	0.7	0.4	0.6	-0.4	0.3
Patch foraging water rate 24 sec	0.4	0.6	1.0	-0.6	0.6	-0.9	-0.7	0.9	0.5	0.8	-1.0	0.9
Patch foraging water rate 6 sec	1.6	2.4	3.2	-1.8	1.5	-1.7	-1.5	1.8	1.3	1.7	-1.4	1.1
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.8	0.6	-0.6	0.4	0.5	-0.4	-0.9	-0.3	0.3	-0.4
Distance traveled before self-admin	4.8	5.1	7.6	-2.8	2.8	-2.4	-2.3	2.5	2.4	2.2	-1.3	1.1
Distance traveled after self-admin	3.0	3.4	5.0	-2.1	2.2	-1.9	-1.8	2.0	2.1	1.9	-1.1	1.0
Extensor digitorum longus weight	0.0	0.2	0.4	-0.4	0.3	-0.5	-0.4	0.6	0.4	0.6	-0.4	0.3
Bone: elastic displacement	0.2	0.2	0.6	0.6	-0.5	-0.0	-0.1	-0.0	0.3	0.0	-0.7	0.8
Bone: elastic work	0.1	0.2	0.6	0.2	-0.1	-0.2	-0.2	0.2	0.4	0.1	-0.7	0.8
Bone: endosteal estimation	0.4	1.0	1.4	-1.2	1.2	-1.0	-1.1	1.1	0.9	1.0	-0.6	0.5
Bone: endosteal perimeter	2.0	4.2	5.7	-2.4	2.4	-2.1	-2.2	2.2	2.1	2.1	-1.4	1.2
Epididymis fat weight	1.3	3.0	3.8	-1.8	1.9	-1.8	-2.0	1.8	1.5	1.7	-1.4	1.4
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	0.6	-0.6	0.5	0.5	-0.5	0.0	-0.5	0.3	-0.2
Delta time in open arm before/after self-admin	1.0	1.0	2.9	-1.7	1.6	-0.8	-0.7	0.9	0.0	0.8	0.5	-0.7
Diff in mean of infusions in LGA sessions	0.1	0.1	0.1	0.4	-0.3	0.1	0.0	-0.3	0.3	-0.1	-0.2	0.3
Delay discount exponential model param	0.2	0.3	0.8	-0.8	0.9	-0.4	-0.3	0.5	0.3	0.4	0.1	-0.3
Extinction: sum of active levers before priming	0.7	0.7	1.8	-0.8	0.6	-0.8	-0.7	0.9	1.3	0.8	-0.9	0.8
Active lever presses in extinction session 6	0.1	0.1	0.3	0.2	-0.2	0.3	0.3	-0.2	0.0	-0.6	0.5	-0.5
Bone: final force	3.5	5.6	6.6	-2.4	2.5	-2.5	-2.6	2.5	2.4	2.3	-2.1	2.0
Bone: final moment	2.7	4.3	5.3	-2.1	2.2	-2.2	-2.3	2.2	2.1	2.0	-1.8	1.7
Food consumed during 24 hour testing period	0.8	1.0	1.5	0.7	-0.6	1.1	1.2	-1.0	-1.0	-1.1	1.1	-1.1
Glucose	0.4	0.6	1.3	-1.0	1.1	-0.6	-0.7	0.7	1.1	0.5	-0.1	-0.0
Heart weight	3.0	4.2	7.7	-2.8	2.7	-2.2	-2.3	2.1	1.8	2.1	-0.8	0.7
Delay discount hyperbolic model param	0.2	0.2	0.7	-0.7	0.8	-0.3	-0.3	0.5	0.3	0.4	0.1	-0.3
Intermittent access intake day 1-15 change	0.4	0.4	0.8	-0.9	0.9	-0.6	-0.7	0.7	0.6	0.5	-0.2	0.1
Intermittent access intake escalation	0.1	0.1	0.3	-0.5	0.4	-0.2	-0.2	0.4	0.4	0.2	-0.0	-0.0
Intermittent access intake escalation 2	0.2	0.2	0.3	0.3	-0.3	0.5	0.4	-0.4	-0.3	-0.5	0.6	-0.5
Intermitt. access day 1 inactive lever presses	0.4	0.4	1.2	-0.1	-0.1	0.5	0.8	-0.5	-0.1	-0.3	1.0	-1.1
Intermitt. access day 15 inactive lever presses	0.3	0.3	1.1	-0.5	0.5	0.2	0.2	-0.2	0.7	-0.2	0.9	-1.1
Intermitt. access escalation Index	0.1	0.1	0.1	0.3	-0.4	0.1	-0.1	-0.1	-0.1	-0.2	-0.3	0.3
Intermittent access day 1 total infusions	0.1	0.1	0.3	0.6	-0.3	0.2	0.0	-0.3	-0.0	-0.4	-0.0	0.1
Intermittent access day 15 total infusions	0.0	0.0	0.1	-0.2	0.3	-0.0	-0.1	0.0	0.3	-0.0	0.2	-0.3
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.3	-0.3	0.3	0.1	-0.1	-0.1	0.3	-0.1	0.5	-0.6
Intermittent access total infusions	0.1	0.1	0.2	-0.0	0.1	0.2	-0.0	-0.2	0.1	-0.3	0.5	-0.5
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.2	-0.3	0.4	0.5	-0.4	-0.1	-0.3	0.4	-0.4
Intermittent access day 15 total locomotion	0.4	0.4	1.4	-0.4	0.5	0.3	0.3	-0.3	-0.0	-0.2	1.1	-1.2
Intermittent access total locomotion	0.1	0.2	0.5	0.0	0.1	0.4	0.3	-0.3	-0.2	-0.4	0.7	-0.7
Intermittent access standard deviation	0.1	0.1	0.6	-0.1	0.1	-0.2	-0.2	0.3	0.7	0.2	-0.4	0.4
Left kidney weight	0.9	2.6	4.1	-2.0	2.0	-1.7	-1.8	1.5	1.7	1.5	-0.7	0.7
Right kidney weight	0.9	2.6	4.4	-2.1	2.0	-1.6	-1.6	1.6	2.1	1.6	-0.6	0.5
Cocaine induced anxiety	5.3	6.1	8.3	1.9	-2.0	2.7	2.7	-2.6	-1.9	-2.6	2.7	-2.9
Post-drug Anxiety	1.6	1.8	2.7	1.0	-1.2	1.4	1.6	-1.3	-0.8	-1.3	1.4	-1.7
Baseline Anxiety	0.6	0.6	0.9	-0.6	0.6	-0.9	-0.8	0.9	0.4	1.0	-0.9	1.0
Tail length	4.8	14.6	16.8	-3.5	3.7	-4.0	-4.0	4.1	4.0	3.8	-3.7	3.6
Length with tail	4.4	16.0	18.8	-4.2	4.2	-4.3	-4.2	4.3	3.8	4.3	-3.3	3.1
Length without tail	1.2	2.6	3.5	-1.9	1.8	-1.8	-1.6	1.8	1.3	1.8	-1.2	1.0
Times rat made contact with spout	0.1	0.1	0.4	-0.3	0.3	0.2	0.4	-0.0	-0.3	-0.2	0.5	-0.6
Lifetime Intake	0.1	0.1	0.4	-0.4	0.5	-0.3	-0.5	0.3	0.6	0.1	-0.1	-0.0
Liver weight, left	0.2	0.4	1.6	-0.3	0.2	0.4	0.3	-0.2	0.1	-0.4	1.1	-1.3
Liver weight, right	0.1	0.1	0.4	0.2	-0.1	-0.2	-0.4	0.2	0.5	0.1	-0.5	0.6
Locomotor activity	0.1	0.2	0.3	-0.4	0.3	-0.5	-0.4	0.3	0.4	0.5	-0.6	0.5
Locomotor testing distance	0.1	0.2	0.4	0.2	-0.3	0.4	0.6	-0.4	-0.3	-0.3	0.4	-0.5
Locomotor testing rearing	0.2	0.3	0.9	-1.0	0.9	-0.5	-0.2	0.5	0.6	0.7	0.0	-0.2
Locomotion in novel chamber	0.1	0.1	0.3	0.5	-0.6	0.3	0.4	-0.3	-0.4	-0.3	0.1	-0.2
Locomotion in novel chamber post-restriction	0.9	1.1	1.5	-1.2	1.0	-1.1	-0.9	1.0	1.1	1.2	-0.9	0.8
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	-0.2	0.1	-0.3	-0.3	0.3	0.3	0.4	-0.4	0.4
Change in fecal boli incidents, locomotor task	0.1	0.1	0.4	0.2	-0.2	0.2	0.3	-0.3	-0.6	-0.2	0.4	-0.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	-0.1	0.2	-0.2	-0.3	0.3	0.5	0.3	-0.4	0.5
Bouts of movement, locomotor time 1	2.0	2.2	3.8	1.9	-1.8	1.6	1.4	-1.6	-1.2	-1.8	0.8	-0.7
Total resting periods, locomotor time 1	1.6	1.7	3.2	1.8	-1.7	1.3	1.3	-1.4	-1.1	-1.5	0.6	-0.4
Rest time, locomotor task time 1	0.2	0.3	0.6	0.7	-0.7	0.4	0.5	-0.5	-0.5	-0.5	0.1	0.0
Distance moved, locomotor task time 1	0.1	0.1	0.2	-0.4	0.5	-0.1	-0.1	0.2	0.4	0.2	0.2	-0.2
Vertical activity count, locomotor time 1	0.3	0.3	1.1	-0.8	1.1	-0.4	-0.6	0.3	0.4	0.4	0.3	-0.2
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	0.2	0.1	-0.0	-0.1	-0.0	0.1	-0.2	-0.1	0.1
Bouts of movement, locomotor time 2	0.6	0.7	1.7	1.3	-1.0	0.8	0.7	-0.7	-0.6	-1.1	-0.1	0.3
Total resting periods, locomotor time 2	0.7	0.7	1.9	1.4	-1.2	0.8	0.7	-0.6	-0.5	-1.0	-0.2	0.4
Rest time, locomotor task time 2	0.5	0.6	1.3	1.1	-1.1	0.7	1.1	-0.5	-0.5	-0.4	-0.3	0.3
Distance moved, locomotor task time 2	0.3	0.3	1.0	-0.6	0.7	0.1	-0.3	-0.1	-0.0	-0.3	1.0	-1.0
Vertical activity count, locomotor time 2	0.6	0.6	1.7	-1.2	1.3	-0.4	-0.6	0.3	0.6	0.1	0.9	-0.9
Light reinforcement 1	1.0	1.8	2.7	-1.1	1.0	-1.4	-1.1	1.3	1.5	1.7	-1.4	1.4
Light reinforcement 2	0.7	0.9	1.6	-0.8	0.8	-1.1	-0.8	1.0	1.1	1.3	-0.9	0.9
Bone: marrow area	0.4	0.9	1.4	-1.2	1.2	-1.0	-1.0	1.0	0.9	0.9	-0.5	0.4
Bone: maximum diameter	4.2	7.6	10.0	-3.1	3.2	-2.8	-3.0	3.0	2.8	2.8	-2.1	1.9
Bone: maximum force	0.6	1.0	1.4	-1.2	1.2	-1.1	-1.1	1.1	1.0	1.0	-0.8	0.8
Bone: maximum moment	0.2	0.4	0.6	-0.8	0.8	-0.7	-0.7	0.7	0.6	0.6	-0.4	0.4
Mean time between licks in bursts	0.0	0.0	0.2	0.1	-0.0	-0.0	-0.4	0.1	-0.1	-0.1	-0.1	0.2
Mean num. licks in bursts	0.4	0.4	1.2	-1.1	1.1	-0.4	-0.3	0.3	0.4	0.3	0.6	-0.7
Cd content in liver	0.1	0.1	0.2	0.4	-0.2	0.2	0.1	-0.4	-0.0	-0.2	0.3	-0.1
Co content in liver	0.7	0.8	1.1	-1.1	0.9	-1.0	-0.9	1.0	1.0	1.0	-0.6	0.5
Cu content in liver	1.8	2.2	3.1	-1.8	1.7	-1.6	-1.4	1.6	1.3	1.6	-1.1	0.9
Fe content in liver	0.0	0.1	0.2	-0.3	0.3	0.0	0.1	0.0	-0.0	-0.1	0.4	-0.4
K content in liver	0.2	0.2	0.3	-0.6	0.5	-0.5	-0.5	0.5	0.3	0.4	-0.3	0.3
Mg content in liver	1.5	1.5	2.3	-1.5	1.4	-1.3	-1.3	1.3	1.2	1.2	-0.8	0.7
Mn content in liver	1.8	2.1	2.5	-1.4	1.5	-1.6	-1.6	1.4	1.5	1.6	-1.3	1.2
Na content in liver	0.1	0.1	0.2	0.2	-0.2	0.2	0.1	-0.2	-0.4	-0.4	0.3	-0.2
Rb content in liver	3.5	4.4	8.7	-2.9	2.8	-2.1	-2.2	2.2	1.9	2.1	-0.7	0.4
Se content in liver	0.7	0.8	1.4	-1.2	1.1	-1.0	-0.8	1.0	0.8	1.0	-0.5	0.4
Sr content in liver	0.6	0.6	1.2	-0.5	0.6	-0.7	-0.9	0.7	1.1	0.7	-0.7	0.8
Zn content in liver	0.2	0.3	0.4	-0.7	0.6	-0.5	-0.6	0.5	0.5	0.4	-0.1	0.2
Bone: minimum diameter	1.5	2.8	3.7	-1.9	1.9	-1.7	-1.9	1.8	1.6	1.7	-1.2	1.1
Time in familiar zone, hab. session 1	1.3	1.3	1.4	1.0	-1.2	1.1	1.2	-1.2	-1.2	-1.0	1.2	-1.1
Time in novel zone, hab. session 1	0.4	0.4	0.8	-0.8	0.9	-0.7	-0.7	0.6	0.6	0.6	-0.4	0.3
Total zone transitions, hab. session 1	0.2	0.2	0.5	-0.7	0.7	-0.5	-0.7	0.1	0.5	0.4	0.3	-0.2
Total locomotion distance, hab. session 1	0.2	0.2	0.6	-0.6	0.5	-0.2	-0.2	-0.1	0.2	0.2	0.8	-0.8
Locomotion velocity, hab. session 1	0.2	0.2	0.5	-0.7	0.6	-0.4	-0.4	0.0	0.4	0.3	0.5	-0.6
Time in familiar zone, hab. session 2	1.6	1.7	2.2	1.2	-1.2	1.4	1.3	-1.3	-1.2	-1.5	1.3	-1.3
Time in novel zone, hab. session 2	1.6	1.6	2.1	-1.2	1.2	-1.4	-1.3	1.4	1.1	1.5	-1.3	1.2
Total zone transitions, hab. session 2	2.4	3.1	4.7	-1.7	1.8	-1.9	-2.2	1.7	1.8	1.8	-1.3	1.3
Total locomotion distance, hab. session 2	0.7	1.0	2.1	-1.5	1.3	-1.0	-1.1	0.7	0.9	1.0	0.2	-0.3
Locomotion velocity, hab. session 2	0.4	0.6	1.4	-1.2	1.1	-0.6	-0.8	0.4	0.6	0.6	0.5	-0.7
Novel to familiar place preference ratio	0.2	0.3	0.7	0.1	-0.2	0.5	0.5	-0.3	-0.3	-0.5	0.7	-0.8
Novelty place preference	0.5	0.5	1.0	0.3	-0.4	0.7	0.7	-0.5	-0.5	-0.7	0.9	-1.0
Time in novel zone, NPP test	0.3	0.3	0.6	0.2	-0.2	0.5	0.5	-0.3	-0.3	-0.6	0.7	-0.8
Total zone transitions, NPP test	0.1	0.2	0.6	-0.2	0.3	-0.6	-0.8	0.2	0.4	0.4	-0.4	0.4
Total locomotion distance, NPP test	0.3	0.4	1.0	-1.0	0.9	-0.5	-0.7	0.3	0.4	0.5	0.5	-0.7
Locomotion velocity, NPP test	0.2	0.2	0.8	-0.6	0.5	-0.2	-0.3	-0.1	0.0	0.2	0.8	-0.9
Intraocular pressure	0.0	0.0	0.2	0.0	-0.2	-0.1	0.1	0.2	0.1	0.2	-0.4	0.3
Delta distance traveled before/after self-admin	0.2	0.2	0.4	-0.3	0.4	-0.5	-0.4	0.4	0.5	0.7	-0.6	0.6
Delta ambulatory time before/after self-admin	0.4	0.4	1.2	1.1	-0.9	0.7	0.6	-0.8	-0.4	-0.6	0.2	-0.0
Parametrial fat weight	0.1	0.2	0.5	0.4	-0.4	0.4	-0.1	-0.4	-0.7	-0.5	0.3	-0.1
Pavlov. Cond. lever latency	0.3	0.3	0.9	-0.2	0.1	-0.5	0.0	0.6	0.4	0.8	-0.9	0.8
Pavlov. Cond. magazine entry latency	0.0	0.1	0.2	-0.3	0.3	-0.3	-0.3	0.2	0.4	0.3	-0.1	0.0
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.3	0.2	-0.2	-0.4	0.1	0.1	0.1	0.1	0.0
Pavlov. Cond. index score	0.0	0.0	0.1	-0.0	0.1	-0.0	-0.3	-0.1	0.1	-0.2	0.2	-0.1
Pavlov. Cond. latency score	0.1	0.1	0.3	0.1	-0.1	0.2	-0.1	-0.4	-0.2	-0.4	0.5	-0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.4	-0.3	0.4	-0.2	-0.6	0.1	0.3	-0.0	0.2	-0.0
Pavlov. Cond. magazine entry number	0.6	0.8	1.3	0.5	-0.5	0.9	0.9	-0.8	-1.0	-0.9	1.1	-1.2
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	-0.6	0.5	-0.3	-0.2	0.4	0.3	0.3	0.1	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.0	-0.0	0.0	-0.2	-0.1	0.1	-0.2	0.2	-0.1
Pavlov. Cond. response bias	0.4	0.5	0.8	-0.6	0.7	-0.7	-0.9	0.6	0.9	0.6	-0.6	0.6
Pavlov. Cond. lever latency	4.0	5.4	6.5	2.1	-2.1	2.5	2.1	-2.5	-2.6	-2.5	2.4	-2.2
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	-0.6	0.7	-0.3	-0.2	0.3	0.2	0.2	0.1	-0.2
Pavlov. Cond. change in total contacts	3.8	5.2	6.1	-2.1	2.1	-2.4	-2.1	2.5	2.3	2.5	-2.3	2.2
Pavlov. Cond. index score	3.3	4.2	4.8	-2.0	2.1	-2.2	-2.0	2.2	2.1	2.1	-1.9	1.8
Pavlov. Cond. latency score	2.5	3.1	3.6	-1.8	1.9	-1.9	-1.7	1.9	1.9	1.8	-1.6	1.5
Pavlov. Cond. lever contacts	3.8	5.2	6.4	-2.2	2.2	-2.4	-2.0	2.5	2.5	2.4	-2.2	2.0
Pavlov. Cond. magazine entry number	0.6	0.7	0.9	0.9	-0.9	0.9	0.7	-0.9	-0.9	-0.9	0.8	-0.7
Pavlov. Cond. intertrial magazine entries	1.0	1.3	1.7	1.0	-1.2	1.1	0.9	-1.3	-1.2	-1.2	1.2	-1.1
Pavlov. Cond. lever-magazine prob. diff.	2.9	3.7	4.3	-1.9	2.0	-2.0	-1.8	2.1	2.0	2.0	-1.7	1.6
Pavlov. Cond. response bias	4.0	5.4	6.5	-2.4	2.4	-2.5	-2.1	2.6	2.5	2.5	-2.1	1.8
Time in closed arm before self-admin	0.2	0.3	0.6	0.6	-0.5	0.5	0.3	-0.5	-0.8	-0.6	0.4	-0.3
Time in closed arm after self-admin	0.5	0.5	1.2	1.1	-1.0	0.7	0.5	-0.8	-0.5	-0.8	0.3	0.0
Time in open arm before self-admin	0.2	0.2	0.6	0.7	-0.8	0.5	0.4	-0.5	0.4	-0.5	-0.0	0.1
Time in open arm after self-admin	0.3	0.3	0.9	-0.9	0.8	-0.3	-0.1	0.4	-0.1	0.3	0.5	-0.8
Bone: periosteal estimation	2.2	4.5	5.5	-2.3	2.3	-2.2	-2.3	2.3	2.1	2.1	-1.7	1.6
Bone: periosteal perimeter	3.1	5.2	7.3	-2.7	2.7	-2.3	-2.5	2.4	2.3	2.2	-1.5	1.3
Bone: post-yield work	0.6	0.9	1.4	0.8	-0.9	1.0	1.2	-0.8	-1.0	-1.0	0.8	-0.8
Progressive ratio test 1 active lever presses	2.5	2.6	3.7	-1.5	1.7	-1.7	-1.9	1.6	1.7	1.5	-1.4	1.4
Progressive ratio test 1 breakpoint	3.2	3.3	4.6	-1.7	1.9	-1.9	-2.1	1.8	2.0	1.7	-1.6	1.6
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.7	-0.8	0.7	-0.5	-0.3	0.4	0.8	0.5	0.1	-0.3
Progressive ratio test 2 active lever presses	0.2	0.3	0.8	-0.7	0.9	-0.4	-0.7	0.3	0.5	0.2	0.2	-0.1
Progressive ratio test 2 breakpoint	0.2	0.2	0.6	-0.6	0.8	-0.4	-0.7	0.3	0.4	0.1	0.1	0.0
Progressive ratio test 2 inactive lever presses	0.4	0.4	0.9	-1.0	0.9	-0.3	-0.2	0.2	0.9	0.3	0.6	-0.8
Incentive Sensitization - Responses	0.2	0.2	0.5	-0.4	0.7	-0.4	-0.7	0.3	0.4	0.2	-0.2	0.4
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	-0.3	0.5	-0.2	-0.5	0.1	0.2	-0.1	0.1	0.1
Sum of active levers in priming session hrs 5-6	1.0	1.0	1.8	-1.3	1.1	-1.1	-0.9	1.2	1.0	1.1	-0.6	0.4
Progressive ratio	2.5	2.9	4.3	2.1	-2.0	1.8	1.9	-1.7	-1.7	-1.7	1.1	-1.0
Food seeking constrained by brief footshock	0.5	0.6	1.6	-1.3	1.0	-0.5	-0.6	0.3	0.8	0.5	0.6	-0.7
Seeking ratio, punishment vs. effort	2.6	3.2	6.1	-2.5	2.3	-1.8	-2.0	1.6	1.9	1.7	-0.7	0.6
Retroperitoneal fat weight	0.0	0.1	0.2	0.2	-0.2	0.1	-0.4	-0.2	-0.4	-0.3	0.2	0.0
Reaction time number correct	0.2	0.3	1.2	-1.1	0.8	-0.5	-0.3	0.5	0.3	0.6	-0.0	-0.3
Reaction time mean minus median	0.7	0.9	1.4	0.9	-0.9	1.0	1.2	-0.9	-1.0	-0.9	0.9	-0.9
Reaction time mean minus median AUC	0.5	0.7	1.1	0.6	-0.7	0.8	1.0	-0.8	-0.9	-0.6	0.9	-0.9
Reaction time num false alarms	1.8	2.5	3.9	-2.0	2.0	-1.7	-1.8	1.6	1.6	1.5	-0.8	0.7
Reaction time num false alarms AUC	2.0	2.7	3.6	-1.8	1.9	-1.8	-1.9	1.6	1.6	1.6	-1.1	1.1
Reaction time trials correct on left	0.2	0.3	1.2	-1.1	0.8	-0.5	-0.3	0.5	0.3	0.6	-0.0	-0.3
Reaction time trials on left	0.3	0.4	1.4	-1.2	0.8	-0.6	-0.4	0.6	0.4	0.7	-0.1	-0.3
Reaction time mean	0.0	0.0	0.1	0.3	-0.2	0.1	0.2	-0.0	-0.0	0.1	-0.2	0.3
Reaction time mean AUC	0.0	0.0	0.1	0.3	-0.2	0.2	0.3	-0.1	-0.0	0.0	-0.1	0.1
Median of all reaction times	0.0	0.1	0.2	0.0	0.1	-0.2	-0.1	0.3	0.1	0.3	-0.4	0.4
Reaction time omissions	0.4	0.6	1.0	-1.0	0.9	-0.7	-0.5	0.8	1.0	1.0	-0.2	0.1
Reaction time false alarm rate	1.0	1.4	2.2	-1.1	1.3	-1.3	-1.5	1.2	1.3	1.1	-0.9	1.0
Reaction time premature initiation rate	0.2	0.3	0.6	0.7	-0.8	0.4	0.6	-0.5	-0.8	-0.4	-0.1	0.1
Reaction time premature initiations	0.1	0.1	0.5	0.2	-0.4	0.3	0.5	-0.4	-0.7	-0.1	0.1	-0.2
Std. dev. reaction times	0.1	0.2	0.5	-0.0	0.1	-0.4	-0.2	0.4	0.3	0.5	-0.7	0.7
Reaction time trials completed	0.3	0.4	1.4	-1.2	0.8	-0.6	-0.4	0.6	0.4	0.7	-0.1	-0.3
Reaction time trials AUC	0.3	0.4	1.4	-1.2	0.9	-0.6	-0.4	0.7	0.4	0.7	-0.2	-0.2
Run reversals in cocaine runway, females	0.2	0.2	0.6	-0.5	0.3	0.2	0.2	-0.0	0.0	-0.1	0.6	-0.8
Run reversals in cocaine runway, males	1.1	1.0	2.2	-1.3	1.1	-1.0	-0.9	0.9	1.5	1.1	-0.4	0.2
Latency to leave start box in cocaine runway	0.4	0.5	0.9	0.9	-0.8	0.8	0.5	-0.8	-0.5	-0.9	0.6	-0.3
Latency to leave start box in cocaine runway, F	1.1	1.2	1.9	1.3	-1.2	1.2	1.0	-1.2	-0.6	-1.4	0.9	-0.7
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.4	0.4	-0.3	-0.3	0.3	0.2	0.1	-0.1	0.0
Std. dev. time between licks in bursts	0.4	0.5	1.1	-0.8	0.9	-0.8	-1.0	0.7	0.5	0.6	-0.4	0.4
Total sessions with >9 infusions	0.5	0.5	0.8	-0.4	0.6	-0.7	-0.9	0.7	0.8	0.5	-0.8	0.8
Short access day 1 total inactive lever presses	0.6	0.6	1.1	1.0	-1.0	0.8	0.9	-1.0	-0.6	-0.7	0.5	-0.4
Short access day 10 total inactive lever presses	3.8	4.2	7.4	1.1	-1.3	2.2	2.2	-2.1	-1.4	-2.2	2.7	-2.7
Short access day 1 total infusions	0.0	0.0	0.1	0.0	0.1	-0.1	-0.3	0.0	0.3	-0.1	-0.1	0.1
Short access day 10 total infusions	0.1	0.1	0.5	0.3	-0.0	-0.1	-0.3	0.1	0.7	-0.1	-0.3	0.3
Short access total infusions	0.3	0.3	0.6	-0.4	0.6	-0.6	-0.8	0.6	0.7	0.3	-0.5	0.4
Short access day 1 locomotion	1.1	1.2	2.8	0.4	-0.5	1.0	0.9	-1.0	-1.0	-1.1	1.6	-1.7
Short access day 10 total locomotion	0.0	0.0	0.1	-0.1	0.1	-0.0	0.1	0.2	0.1	0.1	-0.2	0.2
Short access total locomotion	0.1	0.1	0.2	-0.3	0.3	0.1	0.1	0.1	0.2	0.0	0.3	-0.4
One hour access (0.3 mA shock)	0.1	0.1	0.5	-0.1	0.2	0.2	0.2	-0.2	-0.3	-0.3	0.6	-0.7
Compulsive drug intake	3.7	3.7	5.0	2.2	-2.2	2.0	2.2	-2.0	-2.1	-1.9	1.4	-1.2
One hour access (shock baseline)	0.3	0.4	0.9	-0.9	1.0	-0.5	-0.6	0.7	0.6	0.4	-0.1	-0.0
Social response proportion	1.7	1.8	3.7	-1.9	1.8	-1.3	-1.0	1.5	1.4	1.5	-0.4	0.2
Social responses	4.8	6.2	7.2	-2.6	2.6	-2.6	-2.4	2.7	2.6	2.7	-2.0	1.9
Social time	0.5	0.6	0.9	-0.7	0.7	-0.9	-0.7	0.9	0.6	1.0	-0.7	0.7
Soleus weight	0.0	0.1	0.3	-0.5	0.4	-0.2	-0.1	0.3	0.1	0.3	0.3	-0.5
Bone: stiffness	1.7	2.7	3.2	-1.8	1.8	-1.7	-1.8	1.8	1.6	1.6	-1.3	1.2
Tibialis anterior weight	0.7	2.5	3.0	-1.6	1.5	-1.7	-1.6	1.7	1.7	1.7	-1.4	1.2
Time to tail flick, vehicle, before self-admin	2.3	2.4	3.9	1.1	-1.1	1.5	1.5	-1.5	-2.0	-1.5	1.7	-1.8
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	0.2	-0.3	-0.0	-0.0	0.1	-0.0	-0.2	-0.2	0.2
Time to tail flick, test, before self-admin	1.1	1.0	2.0	-0.7	0.7	-1.1	-1.0	1.0	0.5	1.1	-1.4	1.4
Time to tail flick, test, after self-admin	2.3	2.4	3.3	1.1	-1.3	1.6	1.6	-1.5	-1.6	-1.6	1.8	-1.8
Delta time to tail flick, vehicle, before/after SA	3.8	3.7	6.6	-1.7	1.6	-2.0	-2.0	2.0	2.6	1.8	-1.8	1.8
Delta time to tail flick, test, before/after SA	3.2	2.9	5.3	0.9	-1.1	1.7	1.9	-1.6	-1.6	-1.6	2.1	-2.3
Tibia length	4.3	12.3	14.3	-3.2	3.3	-3.7	-3.6	3.8	3.6	3.6	-3.5	3.3
Ambulatory time before self-admin	4.1	4.3	5.9	-2.3	2.4	-2.1	-2.2	2.3	2.1	2.0	-1.5	1.5
Ambulatory time after self-admin	3.8	4.2	5.7	-2.2	2.4	-2.1	-2.1	2.3	2.2	2.1	-1.4	1.4
Bone: tissue strength	0.1	0.1	0.2	-0.4	0.4	-0.4	-0.3	0.4	0.3	0.5	-0.3	0.2
Total heroin consumption	3.4	4.0	5.2	-2.0	2.0	-2.1	-2.0	1.9	2.3	2.2	-1.8	1.7
Bone: trabecular number	0.6	0.9	1.7	-1.3	1.2	-1.0	-1.0	1.0	0.9	0.8	-0.4	0.3
Bone: trabecular spacing	0.1	0.1	0.4	0.6	-0.6	0.3	0.5	-0.4	-0.1	-0.2	-0.1	0.2
Bone: trabecular thickness	0.3	0.4	0.9	-0.9	1.0	-0.7	-0.8	0.6	0.5	0.5	-0.2	0.2
Bone: trabecular tissue density	1.3	1.9	2.6	-1.6	1.6	-1.4	-1.6	1.3	1.3	1.5	-0.9	0.9
Water consumed over 24 hours	0.1	0.1	0.6	0.4	-0.3	0.4	0.8	-0.2	-0.4	-0.3	0.0	-0.1
Number of responses in last shaping day	0.2	0.2	0.3	0.4	-0.5	0.4	0.6	-0.5	-0.1	-0.1	0.4	-0.5