Hub : Genes

Ptpn23

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Ptpn23	0.09	0.09	2.8e-03	0.03	0.04	0.03	0.02	2.6e-02	1.1e-02	2.5e-02	3.5e-02
2	BLA	gene expression	Ptpn23	0.11	0.11	4.4e-05	0.07	0.08	0.08	0.07	1.1e-04	5.4e-05	7.1e-05	8.1e-05
3	Brain	gene expression	Ptpn23	0.17	0.11	5.6e-17	0.18	0.18	0.18	0.18	1.7e-16	1.1e-16	1.3e-16	1.2e-16
4	PL	gene expression	Ptpn23	0.07	0.08	1.5e-05	0.04	0.04	0.04	0.04	9.4e-06	2.1e-05	1.1e-05	8.7e-06
5	NAcc	gene expression	Ptpn23	0.08	0.07	1.2e-08	0.07	0.07	0.07	0.07	1.0e-08	1.7e-08	7.3e-09	8.8e-09
6	Liver	gene expression	Ptpn23	0.07	0.06	1.8e-08	0.07	0.07	0.06	0.07	4.3e-08	7.0e-08	9.2e-08	6.4e-08
7	Adipose	gene expression	Ptpn23	0.57	0.22	1.3e-10	0.06	0.1	0.11	0.08	2.8e-07	2.2e-11	4.3e-12	5.3e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	0.0	0.0	0.0	0.2	0.2	0.2	0.1	-0.2	-0.1	-0.1
Area under the delay curve	1.9	2.1	2.3	-1.5	-1.5	-1.5	-1.5	1.4	1.3	1.2
BMI with tail	0.3	0.9	1.1	1.0	1.0	1.0	0.9	-0.9	-1.0	0.4
BMI without tail	1.3	2.8	3.7	1.9	1.9	1.9	1.8	-1.8	-1.4	-0.1
Body weight	5.8	24.3	28.4	5.3	5.3	5.3	5.3	-5.2	-4.6	-3.0
Weight adjusted by age	0.2	0.2	0.3	0.5	0.5	0.5	0.4	-0.4	0.1	-0.4
Bone surface	0.1	0.2	0.3	-0.3	-0.3	-0.3	-0.4	0.3	0.6	0.5
Bone volume	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.2	0.1	0.4	0.4
Breakpoint value in progressive ratio session	0.2	0.2	0.5	0.3	0.3	0.3	0.7	-0.5	-0.7	0.1
Number of licking bursts	0.2	0.2	0.5	-0.5	-0.5	-0.5	-0.3	0.3	0.2	0.7
Context. condit. distance diff. score	0.0	0.0	0.0	0.0	0.0	0.0	-0.0	0.0	0.2	0.0
Locomotion velocity, session 1	0.1	0.1	0.2	-0.3	-0.3	-0.3	-0.4	0.4	0.3	0.4
Locomotion distance, session 1	0.6	0.7	1.0	1.0	1.0	1.0	0.8	-0.8	-0.9	-0.3
Locomotion velocity, session 2	0.4	0.4	0.8	-0.6	-0.6	-0.6	-0.7	0.6	0.7	0.9
Locomotion distance, session 2	0.1	0.2	0.6	-0.2	-0.2	-0.2	-0.4	0.4	0.4	0.7
Locomotion velocity, session 3	0.0	0.0	0.1	0.3	0.3	0.3	0.1	-0.2	0.1	0.2
Locomotion distance, session 3	1.3	1.4	2.1	-1.1	-1.1	-1.1	-1.3	1.2	1.3	1.4
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	0.2	0.2	0.2	0.3	-0.2	-0.2	-0.2
Stereotopy head waving duration, day 3	0.3	0.3	0.4	0.5	0.5	0.5	0.6	-0.6	-0.5	-0.5
Locomotion velocity, session 7	0.2	0.2	0.3	0.5	0.5	0.5	0.4	-0.5	-0.1	0.3
Locomotion distance, session 7	0.9	1.2	2.4	-0.9	-0.9	-0.9	-1.0	0.9	1.2	1.5
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.2	0.2	0.2	-0.3
Stereotopy head waving duration, day 7	0.3	0.4	0.8	0.6	0.6	0.6	0.5	-0.5	-0.6	-0.9
Locomotion velocity, session 8	0.1	0.1	0.2	0.4	0.4	0.4	0.3	-0.3	-0.3	0.2
Locomotion distance, session 8	0.1	0.1	0.2	0.5	0.5	0.5	0.2	-0.3	-0.0	0.3
Degree of sensitization distance	1.3	1.3	1.6	1.2	1.2	1.2	1.3	-1.2	-1.2	-0.9
Degree of sensitization stereotypy	0.1	0.1	0.6	0.2	0.2	0.2	0.1	-0.2	-0.2	-0.8
Conditioned locomotion	2.7	3.2	3.6	-1.9	-1.9	-1.9	-1.9	1.9	1.9	1.1
Cocaine response after cond. corrected	0.3	0.3	0.4	0.5	0.5	0.5	0.7	-0.6	-0.6	-0.6
Cocaine response after cond. not corrected	1.8	2.0	2.2	1.4	1.4	1.4	1.5	-1.4	-1.4	-1.3
Cocaine response before conditioning	0.9	1.1	1.4	1.2	1.2	1.2	1.0	-1.0	-0.9	-0.9
Saline control response	1.4	1.9	2.2	1.4	1.4	1.4	1.3	-1.3	-1.3	-1.5
Bone: connectivity density	0.1	0.2	0.3	-0.5	-0.5	-0.5	-0.6	0.5	0.5	-0.1
Bone: cortical apparent density	0.2	0.3	0.3	-0.5	-0.5	-0.5	-0.6	0.5	0.6	-0.0
Bone: cortical area	0.2	0.3	0.7	-0.5	-0.4	-0.5	-0.5	0.5	0.9	0.5
Bone: cortical porosity	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.1	0.0	-0.1	-0.4
Bone: cortical porosity	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.3	0.3	0.2	-0.2
Bone: cortical thickness	0.1	0.1	0.1	0.4	0.4	0.4	0.4	-0.3	0.0	-0.0
Bone: cortical thickness	0.0	0.0	0.0	0.1	0.1	0.1	0.1	-0.1	-0.0	0.2
Bone: cortical tissue density	0.2	0.3	0.3	-0.5	-0.5	-0.5	-0.6	0.6	0.6	-0.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.3	0.3	0.3	0.4	-0.4	-0.2	-0.5
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	0.5	0.5	0.5	0.6	-0.5	-0.5	-0.7
Condit. Reinf. active responses	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.0	0.0	0.3	-0.2
Condit. Reinf. inactive responses	0.6	0.7	1.0	-0.8	-0.8	-0.8	-0.8	0.8	1.0	0.6
Incentive salience index mean	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.3	0.3	0.4	0.2
Condit. Reinf. lever presses	1.7	2.2	2.4	-1.5	-1.5	-1.5	-1.6	1.5	1.5	1.4
Condit. Reinf. active minus inactive responses	1.9	2.3	2.7	1.6	1.6	1.6	1.6	-1.6	-1.7	-0.9
Condit. Reinf. active-inactive response ratio	1.6	1.6	2.1	1.3	1.3	1.3	1.4	-1.4	-1.4	-0.5
Condit. Reinf. active responses	1.7	2.4	2.5	1.6	1.6	1.6	1.5	-1.5	-1.6	-1.3
Condit. Reinf. inactive responses	0.0	0.1	0.2	-0.1	-0.1	-0.2	-0.2	0.2	0.2	-0.5
Condit. Reinf. lever presses	2.2	3.0	3.4	1.8	1.8	1.8	1.8	-1.8	-1.8	-1.0
Condit. Reinf. lever reinforcers received	1.8	2.6	2.8	1.7	1.7	1.6	1.6	-1.6	-1.6	-1.3
Conditioned reinforcement - actives	0.4	0.4	0.7	-0.7	-0.7	-0.7	-0.6	0.6	0.2	0.9
Conditioned reinforcement - inactives	1.0	1.2	1.5	-1.0	-1.0	-1.0	-1.0	1.0	1.2	1.2
Conditioned locomotion	0.3	0.4	0.6	-0.7	-0.7	-0.7	-0.7	0.7	0.1	0.5
Patch foraging indifference point 0 sec	0.8	1.4	1.7	1.3	1.3	1.3	1.0	-1.0	-0.9	-1.2
Patch foraging indifference point AUC	0.1	0.2	0.4	0.3	0.3	0.3	0.4	-0.4	-0.7	0.1
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.2	0.2	-0.3	0.1
Delay disc. indifference point, 16s delay	1.1	1.1	1.6	-1.0	-1.0	-1.0	-1.2	1.1	1.3	0.7
Delay disc. indifference point, 2s delay	0.3	0.3	0.4	-0.6	-0.6	-0.6	-0.6	0.5	0.6	0.4
Delay disc. indifference point, 24s delay	0.9	0.8	1.4	-0.9	-0.9	-0.9	-1.0	0.8	1.2	0.7
Delay disc. indifference point, 4s delay	2.0	2.1	2.4	-1.5	-1.5	-1.5	-1.5	1.4	1.3	1.2
Delay disc. indifference point, 8s delay	1.9	2.0	2.2	-1.5	-1.5	-1.5	-1.5	1.4	1.3	1.2
Indifference point function ln k	0.4	0.5	1.2	-0.5	-0.5	-0.6	-0.9	0.8	1.1	0.5
Indifference point function log k	0.4	0.5	1.2	-0.5	-0.5	-0.6	-0.9	0.8	1.1	0.5
Patch foraging total patch changes 0 sec	1.0	1.6	2.0	1.4	1.4	1.4	1.2	-1.2	-1.1	-1.3
Patch foraging total patch changes 12 sec	1.1	1.4	1.9	1.2	1.2	1.2	1.1	-1.2	-1.1	-1.4
Patch foraging total patch changes 18 sec	2.5	3.2	4.7	1.8	1.8	1.8	1.9	-1.8	-2.2	-1.2
Patch foraging total patch changes 24 sec	3.0	3.6	4.5	2.0	2.0	2.0	1.9	-1.9	-2.1	-1.4
Patch foraging total patch changes 6 sec	0.1	0.2	0.3	0.5	0.5	0.5	0.3	-0.4	-0.4	-0.5
Patch foraging time to switch 0 sec	0.1	0.2	0.3	-0.4	-0.4	-0.4	-0.4	0.4	0.5	0.2
Patch foraging water rate 0 sec	0.1	0.2	0.4	0.4	0.4	0.4	0.3	-0.3	-0.5	-0.6
Patch foraging water rate 12 sec	0.2	0.4	0.5	0.6	0.6	0.6	0.7	-0.6	-0.7	0.4
Patch foraging water rate 18 sec	0.1	0.1	0.6	0.1	0.1	0.1	-0.1	0.1	0.1	0.8
Patch foraging water rate 24 sec	0.8	1.1	1.4	1.0	1.0	1.0	1.1	-1.0	-1.2	-0.9
Patch foraging water rate 6 sec	0.2	0.3	0.4	0.7	0.7	0.6	0.5	-0.5	-0.5	-0.6
Seeking ratio, delayed vs. immediate footshock	2.2	2.6	3.5	-1.8	-1.8	-1.8	-1.4	1.5	0.7	1.9
Distance traveled before self-admin	0.0	0.0	0.1	0.0	0.0	0.0	-0.3	0.1	0.2	-0.0
Distance traveled after self-admin	0.4	0.4	0.8	-0.5	-0.5	-0.5	-0.8	0.7	0.9	0.5
Extensor digitorum longus weight	0.2	0.6	0.7	-0.8	-0.8	-0.8	-0.8	0.7	0.7	0.8
Bone: elastic displacement	0.1	0.1	0.1	0.2	0.2	0.2	0.2	-0.2	-0.3	-0.3
Bone: elastic work	0.4	0.5	0.6	0.8	0.8	0.8	0.7	-0.7	-0.5	-0.4
Bone: endosteal estimation	0.1	0.1	0.2	0.4	0.4	0.4	0.4	-0.4	-0.3	0.0
Bone: endosteal perimeter	1.2	2.6	3.5	-1.6	-1.6	-1.6	-1.7	1.6	1.9	1.2
Epididymis fat weight	0.4	0.9	1.6	0.8	0.8	0.8	1.1	-1.0	-1.3	-0.4
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.4	-0.4	-0.4	-0.2	0.2	0.1	0.4
Delta time in open arm before/after self-admin	0.2	0.2	0.3	0.5	0.5	0.5	0.1	-0.4	0.4	-0.3
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	-0.0	-0.2	0.1
Delay discount exponential model param	2.3	2.4	2.7	1.7	1.7	1.6	1.6	-1.5	-1.4	-1.3
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.1	0.1	0.1	0.2	-0.2	-0.3	0.4
Active lever presses in extinction session 6	0.3	0.3	0.4	0.5	0.5	0.5	0.3	-0.7	-0.1	-0.6
Bone: final force	0.7	1.1	1.4	1.2	1.2	1.2	1.1	-1.1	-0.8	-0.9
Bone: final moment	0.9	1.5	1.8	1.3	1.3	1.3	1.3	-1.2	-0.9	-1.0
Food consumed during 24 hour testing period	1.3	1.5	1.8	1.3	1.3	1.3	1.2	-1.2	-1.2	-1.1
Glucose	0.3	0.5	1.0	0.7	0.7	0.6	0.7	-0.7	-1.0	-0.4
Heart weight	2.5	3.5	3.8	1.9	1.9	1.9	1.9	-1.9	-1.6	-1.9
Delay discount hyperbolic model param	2.2	2.4	2.7	1.6	1.6	1.6	1.6	-1.5	-1.4	-1.3
Intermittent access intake day 1-15 change	0.8	0.8	2.1	-0.8	-0.8	-0.8	-0.8	0.8	1.4	0.7
Intermittent access intake escalation	0.8	0.8	2.1	-0.7	-0.7	-0.7	-0.7	0.7	1.5	0.9
Intermittent access intake escalation 2	0.1	0.1	0.6	0.1	0.1	0.1	-0.0	-0.0	0.8	0.0
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.0	-0.0	-0.1	-0.2	0.2	0.1	0.0
Intermitt. access day 15 inactive lever presses	0.8	0.9	1.4	-0.9	-0.8	-0.8	-0.9	0.9	1.2	1.1
Intermitt. access escalation Index	0.0	0.0	0.1	0.0	0.0	0.0	-0.2	0.1	0.2	0.0
Intermittent access day 1 total infusions	0.1	0.1	0.2	-0.2	-0.2	-0.2	-0.2	0.2	0.1	0.5
Intermittent access day 15 total infusions	0.6	0.7	1.6	-0.7	-0.6	-0.7	-0.7	0.7	1.3	1.1
Intermittent access terminal intake (last 3 days)	0.4	0.4	1.0	-0.4	-0.4	-0.4	-0.6	0.5	1.0	0.8
Intermittent access total infusions	0.7	0.8	1.3	-0.8	-0.8	-0.8	-0.9	0.8	1.1	1.0
Intermittent access day 1 locomotion	0.2	0.2	0.6	-0.4	-0.4	-0.4	-0.4	0.4	0.2	0.8
Intermittent access day 15 total locomotion	0.7	0.7	1.0	-0.8	-0.8	-0.8	-0.9	0.8	1.0	0.9
Intermittent access total locomotion	1.2	1.3	1.7	-1.2	-1.2	-1.2	-1.3	1.2	1.1	0.9
Intermittent access standard deviation	0.1	0.1	0.2	0.4	0.4	0.4	0.4	-0.3	0.2	0.1
Left kidney weight	0.6	1.7	2.1	1.5	1.4	1.5	1.3	-1.4	-1.1	-1.0
Right kidney weight	0.1	0.4	0.6	0.7	0.7	0.7	0.5	-0.6	-0.2	-0.8
Cocaine induced anxiety	0.5	0.6	0.8	-0.8	-0.8	-0.8	-0.8	0.9	0.9	0.4
Post-drug Anxiety	0.2	0.2	0.2	-0.5	-0.5	-0.4	-0.4	0.5	0.5	0.1
Baseline Anxiety	0.2	0.2	0.8	-0.4	-0.4	-0.4	-0.3	0.3	0.5	0.9
Tail length	6.4	19.4	22.1	4.7	4.7	4.7	4.7	-4.6	-4.0	-3.2
Length with tail	8.9	32.8	36.7	6.1	6.1	6.1	6.0	-5.9	-5.1	-4.6
Length without tail	6.3	13.8	14.5	3.8	3.8	3.8	3.8	-3.7	-3.5	-3.6
Times rat made contact with spout	0.6	0.6	1.5	0.7	0.7	0.7	0.7	-0.7	-0.7	-1.2
Lifetime Intake	0.5	0.5	0.8	-0.7	-0.7	-0.7	-0.7	0.7	0.8	0.9
Liver weight, left	0.1	0.2	0.4	0.3	0.3	0.3	0.3	-0.4	-0.5	-0.6
Liver weight, right	1.3	2.2	2.3	1.5	1.5	1.5	1.5	-1.5	-1.5	-1.3
Locomotor activity	4.9	7.8	9.2	3.0	3.0	3.0	2.9	-2.8	-2.5	-2.1
Locomotor testing distance	4.6	7.6	9.1	3.0	3.0	3.0	2.9	-2.9	-2.6	-1.5
Locomotor testing rearing	0.2	0.3	0.3	0.5	0.5	0.5	0.6	-0.5	-0.5	0.5
Locomotion in novel chamber	0.1	0.2	0.3	-0.5	-0.5	-0.5	-0.4	0.5	-0.3	-0.0
Locomotion in novel chamber post-restriction	0.9	1.0	2.0	1.0	1.0	0.9	1.0	-0.9	-1.4	-0.9
Fecal boli incidents, locomotor time 1	0.4	0.4	0.9	0.6	0.7	0.6	0.7	-0.6	-0.9	-0.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.6	0.1	0.1	0.1	0.3	-0.2	-0.8	-0.1
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.2	0.2	0.3	0.2
Bouts of movement, locomotor time 1	0.0	0.1	0.2	0.1	0.1	0.1	0.3	-0.1	-0.5	0.1
Total resting periods, locomotor time 1	0.1	0.1	0.4	0.1	0.1	0.1	0.2	-0.1	-0.6	0.1
Rest time, locomotor task time 1	0.6	0.6	1.3	-0.8	-0.8	-0.8	-0.6	0.8	-0.3	1.2
Distance moved, locomotor task time 1	1.6	1.7	2.0	1.4	1.4	1.4	1.3	-1.4	-0.9	-1.4
Vertical activity count, locomotor time 1	0.9	0.9	1.3	1.0	1.0	1.0	0.9	-0.9	-0.8	-1.1
Time >=10cm from walls, locomotor time 2	1.5	1.6	1.8	1.3	1.3	1.3	1.4	-1.3	-1.3	-0.8
Bouts of movement, locomotor time 2	0.1	0.1	0.5	0.0	0.0	0.0	0.1	-0.1	0.2	0.7
Total resting periods, locomotor time 2	0.2	0.2	1.0	-0.3	-0.3	-0.3	-0.2	0.2	0.4	1.0
Rest time, locomotor task time 2	0.1	0.1	0.5	-0.2	-0.2	-0.2	-0.1	0.3	-0.4	0.7
Distance moved, locomotor task time 2	1.1	1.3	2.3	1.2	1.1	1.1	1.0	-1.2	-0.4	-1.5
Vertical activity count, locomotor time 2	0.1	0.1	0.2	0.3	0.3	0.3	0.2	-0.3	0.1	-0.5
Light reinforcement 1	0.6	1.1	1.4	1.1	1.2	1.2	1.2	-1.2	-1.0	-0.4
Light reinforcement 2	0.1	0.2	0.4	-0.3	-0.3	-0.3	-0.4	0.4	0.6	0.4
Bone: marrow area	0.1	0.1	0.2	0.4	0.4	0.4	0.4	-0.4	-0.3	-0.0
Bone: maximum diameter	0.5	0.9	1.3	-0.9	-0.9	-0.9	-1.0	1.0	1.1	0.6
Bone: maximum force	0.6	1.0	1.2	1.1	1.1	1.1	1.1	-1.1	-0.7	-0.9
Bone: maximum moment	0.7	1.2	1.4	1.2	1.2	1.2	1.2	-1.1	-0.7	-0.9
Mean time between licks in bursts	1.1	1.6	1.8	-1.3	-1.3	-1.3	-1.3	1.2	1.1	1.3
Mean num. licks in bursts	0.7	0.9	2.3	0.9	0.9	0.9	0.7	-0.7	-0.6	-1.5
Cd content in liver	2.6	2.9	3.2	1.6	1.6	1.6	1.8	-1.7	-1.8	-1.8
Co content in liver	0.1	0.1	0.6	0.0	0.0	0.0	-0.1	0.0	0.8	0.3
Cu content in liver	4.2	5.1	7.1	2.2	2.2	2.2	2.3	-2.3	-2.7	-1.8
Fe content in liver	2.2	2.7	4.0	1.4	1.4	1.4	1.7	-1.6	-1.9	-2.0
K content in liver	0.7	0.7	1.1	0.9	0.9	0.9	0.9	-0.8	-1.1	-0.5
Mg content in liver	0.0	0.0	0.3	-0.0	-0.0	-0.0	-0.1	0.0	-0.0	0.5
Mn content in liver	0.4	0.5	0.7	0.8	0.8	0.8	0.6	-0.7	-0.4	-0.3
Na content in liver	0.5	0.5	1.1	0.6	0.6	0.6	0.7	-0.7	-0.7	-1.0
Rb content in liver	1.3	1.6	2.3	1.1	1.1	1.1	1.4	-1.3	-1.2	-1.5
Se content in liver	0.1	0.1	0.2	0.2	0.2	0.2	0.3	-0.2	-0.4	-0.3
Sr content in liver	0.0	0.0	0.3	0.0	0.0	0.0	-0.1	0.1	0.1	0.5
Zn content in liver	4.3	4.8	6.7	2.2	2.2	2.2	2.2	-2.1	-2.6	-1.7
Bone: minimum diameter	0.5	0.9	1.5	-0.8	-0.8	-0.8	-0.9	0.9	1.2	1.0
Time in familiar zone, hab. session 1	1.4	1.3	1.4	-1.2	-1.2	-1.2	-1.1	1.1	1.2	1.1
Time in novel zone, hab. session 1	0.7	0.7	1.3	0.8	0.8	0.8	0.7	-0.7	-0.6	-1.1
Total zone transitions, hab. session 1	0.3	0.5	0.8	0.9	0.9	0.9	0.6	-0.6	-0.5	-0.1
Total locomotion distance, hab. session 1	0.2	0.3	0.3	0.6	0.6	0.6	0.5	-0.6	-0.6	-0.2
Locomotion velocity, hab. session 1	0.2	0.3	0.4	0.6	0.6	0.6	0.5	-0.6	-0.6	-0.2
Time in familiar zone, hab. session 2	0.6	0.6	0.9	-0.8	-0.8	-0.8	-0.7	0.7	0.7	1.0
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.2	0.2	0.2	0.1	-0.1	-0.1	-0.4
Total zone transitions, hab. session 2	0.0	0.1	0.3	0.2	0.2	0.2	-0.0	0.0	0.1	0.5
Total locomotion distance, hab. session 2	0.2	0.3	0.5	0.6	0.6	0.6	0.5	-0.6	-0.7	-0.1
Locomotion velocity, hab. session 2	0.1	0.2	0.3	0.5	0.5	0.5	0.4	-0.5	-0.6	-0.1
Novel to familiar place preference ratio	0.8	0.8	1.0	0.9	0.9	0.9	0.8	-0.9	-1.0	-0.7
Novelty place preference	0.8	0.8	0.9	0.9	0.9	0.9	0.8	-0.9	-1.0	-0.8
Time in novel zone, NPP test	1.0	1.1	1.2	1.1	1.1	1.1	1.0	-1.0	-1.1	-0.9
Total zone transitions, NPP test	1.5	2.2	3.0	1.7	1.7	1.7	1.4	-1.5	-1.4	-0.7
Total locomotion distance, NPP test	0.8	1.2	1.4	1.1	1.1	1.1	1.1	-1.1	-1.2	-0.7
Locomotion velocity, NPP test	0.9	1.2	1.5	1.2	1.2	1.2	1.1	-1.1	-1.2	-0.7
Intraocular pressure	1.3	1.8	2.3	1.2	1.2	1.2	1.4	-1.4	-1.5	-1.2
Delta distance traveled before/after self-admin	0.3	0.3	0.6	-0.4	-0.4	-0.4	-0.5	0.5	0.8	0.4
Delta ambulatory time before/after self-admin	0.2	0.2	0.3	0.5	0.5	0.5	0.4	-0.4	-0.0	0.0
Parametrial fat weight	1.1	2.1	2.4	1.5	1.5	1.5	1.4	-1.5	-1.4	-1.1
Pavlov. Cond. lever latency	5.5	7.0	7.4	2.7	2.7	2.7	2.7	-2.6	-2.4	-2.7
Pavlov. Cond. magazine entry latency	6.9	8.8	9.3	-3.0	-3.0	-3.0	-3.0	3.0	3.0	2.7
Pavlov. Cond. change in total contacts	1.6	1.7	2.1	-1.4	-1.4	-1.4	-1.3	1.3	1.1	1.1
Pavlov. Cond. index score	6.7	8.5	9.0	-3.0	-3.0	-3.0	-3.0	3.0	2.7	2.8
Pavlov. Cond. latency score	6.7	8.5	8.8	-3.0	-3.0	-3.0	-3.0	2.9	2.7	2.8
Pavlov. Cond. lever contacts	3.2	3.7	4.0	-2.0	-2.0	-2.0	-2.0	2.0	1.7	1.9
Pavlov. Cond. magazine entry number	7.6	9.5	10.2	3.2	3.2	3.2	3.2	-3.1	-3.0	-2.7
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.5	0.7	0.7	0.7	0.7	-0.7	-0.5	-0.4
Pavlov. Cond. lever-magazine prob. diff.	6.0	7.4	7.9	-2.8	-2.8	-2.8	-2.8	2.8	2.5	2.6
Pavlov. Cond. response bias	7.3	8.8	9.4	-3.0	-3.1	-3.1	-3.0	3.0	2.8	2.7
Pavlov. Cond. lever latency	0.3	0.4	0.5	-0.7	-0.7	-0.7	-0.7	0.7	0.7	0.1
Pavlov. Cond. magazine entry latency	0.2	0.3	1.0	-0.4	-0.4	-0.4	-0.4	0.4	0.4	1.0
Pavlov. Cond. change in total contacts	2.0	2.8	3.3	1.8	1.8	1.8	1.8	-1.8	-1.8	-0.8
Pavlov. Cond. index score	0.1	0.1	0.2	0.3	0.3	0.2	0.2	-0.2	-0.3	0.4
Pavlov. Cond. latency score	0.0	0.1	0.2	0.2	0.2	0.2	0.2	-0.2	-0.2	0.5
Pavlov. Cond. lever contacts	0.8	1.1	1.4	1.1	1.1	1.1	1.1	-1.1	-1.2	-0.4
Pavlov. Cond. magazine entry number	0.5	0.6	1.1	0.7	0.7	0.7	0.7	-0.7	-0.7	-1.1
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.7	-0.7	-0.7	-0.7	-0.7	0.7	0.8	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	0.2	0.2	0.2	0.2	-0.2	-0.2	0.5
Pavlov. Cond. response bias	0.1	0.1	0.3	0.2	0.2	0.2	0.2	-0.2	-0.3	0.5
Time in closed arm before self-admin	1.4	1.6	1.8	1.4	1.4	1.4	1.2	-1.3	-1.0	-1.2
Time in closed arm after self-admin	0.0	0.0	0.1	0.1	0.1	0.1	0.3	-0.2	-0.2	-0.1
Time in open arm before self-admin	0.9	1.0	1.3	-1.1	-1.1	-1.1	-1.0	1.0	0.8	0.9
Time in open arm after self-admin	0.4	0.4	1.5	-0.4	-0.4	-0.4	-0.8	0.5	1.2	0.3
Bone: periosteal estimation	0.0	0.0	0.1	0.1	0.1	0.1	0.1	-0.1	0.3	0.2
Bone: periosteal perimeter	1.3	2.2	3.2	-1.4	-1.4	-1.5	-1.5	1.5	1.8	1.1
Bone: post-yield work	0.0	0.0	0.0	0.2	0.2	0.2	0.1	-0.1	0.0	0.1
Progressive ratio test 1 active lever presses	0.0	0.0	0.2	-0.1	-0.1	-0.1	-0.1	0.1	0.0	0.5
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	-0.2	-0.2	-0.2	-0.2	0.2	0.1	0.5
Progressive ratio test 1 inactive lever presses	0.4	0.5	1.0	-0.7	-0.7	-0.7	-0.6	0.7	0.4	1.0
Progressive ratio test 2 active lever presses	1.0	1.1	1.2	-1.1	-1.1	-1.1	-1.1	1.0	1.1	1.1
Progressive ratio test 2 breakpoint	0.8	0.9	1.0	-1.0	-1.0	-1.0	-1.0	0.9	1.0	0.7
Progressive ratio test 2 inactive lever presses	2.4	2.8	3.5	-1.6	-1.6	-1.6	-1.7	1.7	1.9	1.5
Incentive Sensitization - Responses	1.6	1.7	1.8	-1.3	-1.3	-1.3	-1.3	1.3	1.2	1.1
Incentive Sensitization - Breakpoint	1.6	1.6	1.8	-1.3	-1.3	-1.3	-1.3	1.3	1.3	1.1
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.8	0.7	0.7	0.7	0.6	-0.7	-0.7	-0.9
Progressive ratio	3.6	4.1	5.3	2.0	2.0	2.0	2.0	-1.9	-2.3	-2.0
Food seeking constrained by brief footshock	0.8	1.0	1.9	-0.9	-1.0	-1.0	-1.1	1.0	1.4	0.3
Seeking ratio, punishment vs. effort	5.6	6.8	9.1	-2.6	-2.6	-2.6	-2.7	2.6	3.0	2.2
Retroperitoneal fat weight	0.6	1.8	2.2	1.5	1.5	1.5	1.4	-1.4	-1.0	-1.0
Reaction time number correct	0.4	0.6	1.1	-0.7	-0.7	-0.7	-0.8	0.8	1.0	0.8
Reaction time mean minus median	0.1	0.1	0.2	0.2	0.2	0.2	0.4	-0.4	-0.4	-0.1
Reaction time mean minus median AUC	0.3	0.4	1.0	0.5	0.5	0.5	0.8	-0.8	-1.0	-0.3
Reaction time num false alarms	0.4	0.6	1.4	-0.6	-0.6	-0.6	-0.6	0.5	1.2	0.8
Reaction time num false alarms AUC	0.1	0.2	0.9	-0.2	-0.2	-0.2	-0.3	0.3	0.9	0.2
Reaction time trials correct on left	0.4	0.6	1.1	-0.7	-0.7	-0.7	-0.8	0.8	1.0	0.8
Reaction time trials on left	0.5	0.7	1.1	-0.7	-0.7	-0.7	-0.8	0.8	1.1	0.8
Reaction time mean	0.0	0.0	0.1	0.1	0.1	0.1	0.2	-0.2	-0.3	-0.1
Reaction time mean AUC	0.0	0.0	0.0	-0.0	-0.0	-0.0	0.1	-0.2	-0.2	-0.1
Median of all reaction times	0.0	0.0	0.0	0.1	0.1	0.1	0.1	-0.1	-0.1	-0.1
Reaction time omissions	0.1	0.1	0.3	-0.5	-0.5	-0.5	-0.3	0.3	0.2	-0.0
Reaction time false alarm rate	0.0	0.0	0.3	-0.1	-0.1	-0.1	-0.1	0.1	0.5	-0.0
Reaction time premature initiation rate	2.1	2.8	3.2	1.7	1.7	1.7	1.8	-1.8	-1.6	-1.2
Reaction time premature initiations	0.9	1.2	1.5	1.2	1.2	1.2	1.2	-1.2	-0.8	-0.7
Std. dev. reaction times	0.1	0.2	0.3	0.3	0.3	0.3	0.5	-0.5	-0.5	-0.2
Reaction time trials completed	0.5	0.7	1.1	-0.7	-0.7	-0.7	-0.8	0.8	1.1	0.8
Reaction time trials AUC	0.6	0.9	1.3	-0.8	-0.8	-0.8	-0.9	0.9	1.1	1.0
Run reversals in cocaine runway, females	1.8	1.7	2.6	-1.3	-1.3	-1.3	-1.4	1.4	1.6	0.6
Run reversals in cocaine runway, males	0.6	0.6	0.7	0.8	0.8	0.8	0.8	-0.7	-0.6	-0.9
Latency to leave start box in cocaine runway	0.5	0.5	1.2	0.6	0.6	0.6	0.7	-0.6	-1.1	-0.7
Latency to leave start box in cocaine runway, F	1.2	1.3	1.5	1.2	1.2	1.2	1.2	-1.2	-1.0	-1.0
Latency to leave start box in cocaine runway, M	0.3	0.2	0.3	-0.6	-0.6	-0.5	-0.4	0.5	-0.4	0.4
Std. dev. time between licks in bursts	4.5	5.3	6.5	-2.3	-2.3	-2.3	-2.2	2.3	2.2	2.6
Total sessions with >9 infusions	0.1	0.1	0.7	-0.3	-0.3	-0.3	0.0	0.0	-0.1	0.8
Short access day 1 total inactive lever presses	4.0	4.4	7.2	-2.1	-2.1	-2.1	-1.9	1.9	1.7	2.7
Short access day 10 total inactive lever presses	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.0	0.1	0.2	0.2
Short access day 1 total infusions	0.8	0.8	1.6	-1.0	-1.0	-1.0	-0.8	0.7	0.4	1.3
Short access day 10 total infusions	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.3	0.3	0.3	0.5
Short access total infusions	0.6	0.6	1.0	-0.8	-0.8	-0.8	-0.7	0.7	0.6	1.0
Short access day 1 locomotion	0.1	0.1	0.1	-0.2	-0.2	-0.3	-0.2	0.2	-0.2	0.3
Short access day 10 total locomotion	0.1	0.1	0.3	0.1	0.1	0.1	0.1	0.0	-0.6	-0.2
Short access total locomotion	0.0	0.0	0.2	-0.1	-0.1	-0.1	-0.1	0.2	-0.5	0.1
One hour access (0.3 mA shock)	0.3	0.4	0.7	-0.4	-0.4	-0.5	-0.6	0.4	0.8	0.8
Compulsive drug intake	0.0	0.0	0.0	-0.1	-0.1	-0.0	-0.1	0.0	0.0	0.2
One hour access (shock baseline)	0.2	0.2	0.6	-0.3	-0.3	-0.3	-0.5	0.4	0.8	0.6
Social response proportion	0.7	0.8	2.5	0.8	0.8	0.8	0.7	-0.7	-0.4	-1.6
Social responses	0.3	0.4	0.5	0.7	0.7	0.7	0.6	-0.7	-0.4	-0.7
Social time	0.5	0.7	1.9	-0.7	-0.7	-0.7	-0.9	0.9	1.4	0.3
Soleus weight	3.5	10.2	11.4	3.4	3.4	3.4	3.4	-3.3	-3.2	-2.2
Bone: stiffness	0.1	0.2	0.3	0.5	0.5	0.5	0.5	-0.5	-0.2	-0.6
Tibialis anterior weight	0.0	0.0	0.0	0.1	0.1	0.1	0.2	-0.2	-0.1	0.1
Time to tail flick, vehicle, before self-admin	2.5	2.5	3.7	1.4	1.4	1.4	1.8	-1.7	-1.9	-1.3
Time to tail flick, vehicle, after self-admin	0.6	0.7	1.4	0.8	0.8	0.8	0.4	-0.6	-0.8	-1.2
Time to tail flick, test, before self-admin	0.1	0.1	0.4	0.3	0.3	0.3	0.2	-0.3	-0.2	-0.7
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.4	-0.4	-0.4	-0.3	0.3	0.1	0.1
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.1	-0.7	-0.7	-0.7	-1.0	1.0	0.8	0.4
Delta time to tail flick, test, before/after SA	0.4	0.4	0.8	-0.6	-0.6	-0.6	-0.4	0.6	0.3	0.9
Tibia length	5.8	16.3	19.4	4.4	4.4	4.4	4.1	-4.1	-3.8	-2.8
Ambulatory time before self-admin	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.3	0.3	0.5	0.5
Ambulatory time after self-admin	0.1	0.1	0.4	-0.2	-0.1	-0.1	-0.4	0.3	0.7	0.3
Bone: tissue strength	2.7	2.6	3.1	1.7	1.7	1.7	1.8	-1.7	-1.4	-1.1
Total heroin consumption	1.0	1.1	1.5	1.2	1.2	1.2	1.2	-1.2	-0.8	-0.3
Bone: trabecular number	0.6	0.9	1.2	-1.0	-1.0	-0.9	-1.1	0.9	1.1	0.8
Bone: trabecular spacing	1.4	1.8	2.2	1.4	1.4	1.4	1.5	-1.4	-1.3	-1.0
Bone: trabecular thickness	0.0	0.0	0.0	0.2	0.2	0.2	0.1	-0.2	-0.2	-0.2
Bone: trabecular tissue density	0.2	0.3	0.4	0.6	0.6	0.6	0.5	-0.6	-0.4	-0.4
Water consumed over 24 hours	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.1	0.1	0.2	-0.2
Number of responses in last shaping day	1.0	1.1	1.8	-0.9	-0.9	-0.9	-0.9	0.9	1.2	1.3