Hub : Genes

Ptges3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Ptges3 0.2 0.13 6.8e-04 0.12 0.12 0.14 0.14 9.1e-04 7.4e-04 2.9e-04 3.3e-04
2 pVTA mRNA stability Ptges3 0.09 0.07 1.7e-03 0.05 0.05 0.05 0.05 2.8e-03 2.2e-03 2.3e-03 2.8e-03
3 NAcc gene expression Ptges3 0.06 0.04 2.7e-07 0.04 0.04 0.04 0.04 2.3e-05 5.9e-06 8.7e-06 8.9e-06
4 Liver gene expression Ptges3 0.17 0.09 5.6e-17 0.12 0.14 0.13 0.13 5.7e-13 5.3e-15 1.1e-14 3.4e-14
5 RMTg gene expression Ptges3 0.39 0.2 1.2e-06 0.16 0.18 0.19 0.19 4.3e-05 1.7e-05 6.9e-06 7.0e-06
6 BLA gene expression Ptges3 0.1 0.08 8.3e-04 0.05 0.04 0.04 0.04 1.3e-03 3.2e-03 2.5e-03 3.3e-03
7 Adipose mRNA stability Ptges3 0.08 0.05 8.6e-08 0.06 0.04 0.05 0.05 1.6e-07 1.1e-05 5.0e-06 1.4e-06
8 PL mRNA stability Ptges3 0.05 0.04 6.7e-05 0.03 0.02 0 0.02 1.7e-04 2.3e-03 1.1e-01 1.3e-03
9 PL gene expression Ptges3 0.06 0.04 1.6e-05 0.02 0.03 0.04 0.03 2.2e-03 1.2e-04 8.2e-05 2.8e-04
10 pVTA gene expression Ptges3 0.12 0.09 4.5e-03 0.07 0.06 0.06 0.06 6.9e-04 1.7e-03 1.5e-03 9.1e-04
11 OFC gene expression Ptges3 0.32 0.16 3.1e-05 0.18 0.07 0.12 0.16 3.9e-05 8.8e-03 8.7e-04 1.5e-04
12 PL intron excision ratio chr7_503414_505463 0.03 0.02 1.4e-03 0.03 0.02 0.01 0.02 6.2e-04 2.2e-03 1.4e-02 1.9e-03
13 Adipose gene expression Ptges3 0.16 0.08 0.0e+00 0.1 0.14 0.14 0.14 4.9e-11 1.5e-15 2.4e-15 1.8e-15

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.40.65.20.1-0.3-0.2-0.2-0.1-0.9-0.8-0.8-0.2-0.2-0.60.62.3
Area under the delay curve0.00.00.1-0.0-0.1-0.0-0.0-0.1-0.2-0.00.10.1-0.1-0.10.10.4
BMI with tail8.126.431.7-5.35.35.3-5.3-5.3-5.2-5.1-5.1-5.6-5.3-5.25.2-2.9
BMI without tail1.32.73.5-1.71.91.9-1.8-1.8-1.5-1.6-1.6-1.5-1.5-1.61.6-1.5
Body weight1.14.85.7-2.32.42.4-2.4-2.3-2.1-2.3-2.3-2.1-2.2-2.12.1-1.4
Weight adjusted by age0.10.10.4-0.10.10.10.0-0.10.10.20.20.20.10.3-0.3-0.6
Bone surface0.71.312.10.5-0.9-0.70.00.4-0.8-0.9-0.90.0-0.3-0.50.53.5
Bone volume0.81.311.60.3-0.7-0.5-0.20.1-1.1-1.1-1.1-0.0-0.4-0.70.73.4
Breakpoint value in progressive ratio session2.22.53.61.6-1.5-1.51.61.51.81.71.71.91.51.5-1.50.5
Number of licking bursts3.23.84.8-2.02.22.2-2.0-2.1-1.6-1.7-1.7-2.1-2.0-1.81.8-2.1
Context. condit. distance diff. score0.20.20.3-0.50.50.5-0.5-0.5-0.5-0.5-0.5-0.5-0.3-0.30.3-0.4
Locomotion velocity, session 10.20.21.4-0.0-0.1-0.0-0.2-0.2-0.5-0.5-0.50.4-0.2-0.20.21.2
Locomotion distance, session 10.30.33.00.6-0.6-0.60.30.40.0-0.1-0.10.2-0.1-0.10.11.7
Locomotion velocity, session 21.21.45.31.2-1.4-1.31.01.20.60.50.51.40.80.8-0.82.3
Locomotion distance, session 22.33.37.12.2-2.2-2.11.82.01.51.41.41.71.31.3-1.32.7
Locomotion velocity, session 35.56.48.02.7-2.5-2.52.62.62.72.52.52.82.62.6-2.61.3
Locomotion distance, session 30.10.10.30.5-0.3-0.30.30.40.60.40.40.40.40.4-0.4-0.0
Stereotopy head waving bouts, day 35.46.37.52.7-2.7-2.72.72.62.42.52.52.42.42.4-2.42.0
Stereotopy head waving duration, day 33.23.84.52.1-2.1-2.12.12.11.91.91.92.01.91.9-1.91.5
Locomotion velocity, session 70.10.10.40.2-0.3-0.30.20.30.00.10.10.0-0.1-0.10.10.6
Locomotion distance, session 70.10.20.8-0.40.40.4-0.2-0.3-0.1-0.1-0.1-0.5-0.4-0.40.4-0.9
Stereotopy head waving bouts, day 70.91.02.61.1-1.2-1.10.91.10.70.70.70.80.90.9-0.91.6
Stereotopy head waving duration, day 70.81.03.31.0-1.2-1.10.91.00.50.60.60.90.80.8-0.81.8
Locomotion velocity, session 81.41.75.41.5-1.6-1.51.21.40.90.80.81.40.90.9-0.92.3
Locomotion distance, session 80.30.50.80.9-0.8-0.80.70.80.70.60.60.60.50.5-0.50.9
Degree of sensitization distance0.80.81.2-0.90.80.8-0.8-0.9-0.9-0.8-0.8-1.1-1.0-1.01.0-0.4
Degree of sensitization stereotypy0.10.10.6-0.10.00.1-0.2-0.1-0.4-0.4-0.4-0.3-0.2-0.20.20.7
Conditioned locomotion0.81.03.3-1.11.21.1-0.9-1.0-0.6-0.5-0.5-1.0-0.7-0.80.8-1.8
Cocaine response after cond. corrected2.12.44.5-1.91.81.8-1.5-1.6-1.4-1.2-1.2-1.4-1.2-1.31.3-2.1
Cocaine response after cond. not corrected2.22.45.0-1.91.81.8-1.5-1.7-1.4-1.2-1.2-1.4-1.1-1.21.2-2.2
Cocaine response before conditioning0.50.61.00.9-0.9-0.80.80.80.70.70.70.60.71.0-1.00.8
Saline control response0.20.30.5-0.60.70.7-0.7-0.7-0.5-0.6-0.6-0.4-0.40.3-0.3-0.7
Bone: connectivity density0.20.33.00.1-0.3-0.2-0.1-0.0-0.6-0.6-0.6-0.0-0.1-0.40.41.7
Bone: cortical apparent density1.41.92.7-1.61.51.5-1.5-1.6-1.6-1.5-1.5-0.9-1.1-1.21.2-0.8
Bone: cortical area1.52.23.3-1.21.01.1-1.4-1.3-1.8-1.8-1.8-1.3-1.8-1.81.80.8
Bone: cortical porosity0.10.10.50.2-0.1-0.1-0.10.0-0.1-0.2-0.2-0.3-0.7-0.50.50.6
Bone: cortical porosity0.40.51.3-0.20.30.3-0.5-0.4-0.6-0.8-0.8-0.6-1.1-1.01.00.8
Bone: cortical thickness1.93.14.0-1.61.61.6-1.8-1.8-1.9-1.9-1.9-1.7-2.0-2.02.0-0.2
Bone: cortical thickness0.80.91.2-0.81.11.1-1.0-1.1-0.6-0.9-0.9-0.8-1.0-1.01.0-1.0
Bone: cortical tissue density1.01.32.0-1.41.21.3-1.3-1.3-1.4-1.3-1.3-0.6-0.8-1.01.0-0.7
Condit. Reinf. active minus inactive responses1.82.12.91.7-1.5-1.51.51.61.61.41.41.31.41.4-1.41.0
Condit. Reinf. active-inactive response ratio0.20.30.50.6-0.4-0.40.50.50.70.60.60.30.50.5-0.5-0.2
Condit. Reinf. active responses2.53.14.32.1-2.0-1.91.81.91.71.51.51.61.51.6-1.61.9
Condit. Reinf. inactive responses1.31.53.41.5-1.5-1.51.21.31.01.01.01.11.01.0-1.01.8
Incentive salience index mean1.21.52.21.5-1.4-1.31.21.31.20.90.91.21.01.0-1.01.5
Condit. Reinf. lever presses0.40.64.00.8-0.9-0.80.50.70.20.00.00.70.30.3-0.32.0
Condit. Reinf. active minus inactive responses1.82.33.31.4-1.4-1.41.61.51.71.81.81.51.51.5-1.5-0.0
Condit. Reinf. active-inactive response ratio0.80.81.50.5-0.5-0.60.90.71.01.21.20.91.01.0-1.0-1.1
Condit. Reinf. active responses1.01.51.91.3-1.3-1.31.41.31.31.41.41.11.21.0-1.00.6
Condit. Reinf. inactive responses0.20.30.90.7-0.7-0.60.50.50.40.30.30.30.40.1-0.10.9
Condit. Reinf. lever presses2.73.74.82.0-1.8-1.92.01.92.22.22.21.92.11.9-1.90.3
Condit. Reinf. lever reinforcers received0.81.11.71.1-1.1-1.11.21.11.21.31.31.01.00.8-0.80.2
Conditioned reinforcement - actives0.10.10.4-0.1-0.0-0.0-0.1-0.1-0.4-0.3-0.3-0.1-0.2-0.20.20.6
Conditioned reinforcement - inactives1.11.32.4-1.41.41.4-1.3-1.3-1.0-1.0-1.0-0.9-0.6-0.60.6-1.6
Conditioned locomotion1.72.12.71.6-1.6-1.61.61.61.51.51.51.21.31.3-1.31.2
Patch foraging indifference point 0 sec4.16.78.1-2.62.62.6-2.7-2.7-2.8-2.8-2.8-2.8-2.8-2.52.5-1.0
Patch foraging indifference point AUC0.70.81.40.8-0.8-0.90.90.90.90.90.90.70.91.2-1.20.3
Delay disc. indifference point, 0s delay1.61.72.9-0.90.80.9-1.2-1.1-1.4-1.5-1.4-1.4-1.7-1.71.70.9
Delay disc. indifference point, 16s delay0.30.30.50.5-0.6-0.60.60.50.50.60.70.50.40.5-0.50.4
Delay disc. indifference point, 2s delay0.20.20.4-0.30.30.3-0.5-0.4-0.6-0.5-0.5-0.3-0.5-0.40.40.5
Delay disc. indifference point, 24s delay0.30.20.6-0.40.40.4-0.4-0.4-0.5-0.3-0.3-0.7-0.8-0.60.6-0.1
Delay disc. indifference point, 4s delay0.30.31.50.6-0.8-0.70.60.60.20.40.50.40.30.3-0.31.2
Delay disc. indifference point, 8s delay0.10.10.4-0.30.30.3-0.1-0.3-0.20.10.20.1-0.1-0.00.0-0.7
Indifference point function ln k0.20.30.5-0.50.60.6-0.6-0.5-0.5-0.6-0.6-0.5-0.4-0.70.7-0.3
Indifference point function log k0.20.30.5-0.50.60.6-0.6-0.5-0.5-0.6-0.6-0.5-0.4-0.70.7-0.3
Patch foraging total patch changes 0 sec3.96.37.6-2.62.52.6-2.6-2.6-2.6-2.6-2.6-2.7-2.8-2.42.4-1.1
Patch foraging total patch changes 12 sec1.82.33.0-1.61.71.7-1.6-1.6-1.3-1.4-1.4-1.7-1.5-1.31.3-1.6
Patch foraging total patch changes 18 sec0.00.00.2-0.30.20.2-0.2-0.2-0.3-0.1-0.1-0.2-0.5-0.20.2-0.1
Patch foraging total patch changes 24 sec0.50.60.8-0.70.70.8-0.8-0.8-0.9-0.9-0.9-0.8-0.7-0.60.6-0.1
Patch foraging total patch changes 6 sec2.23.34.0-1.81.91.9-1.9-1.9-1.8-1.9-1.9-2.0-2.0-1.71.7-0.9
Patch foraging time to switch 0 sec0.20.30.6-0.50.40.4-0.5-0.5-0.7-0.7-0.7-0.3-0.8-0.80.80.4
Patch foraging water rate 0 sec0.40.71.8-1.01.11.0-0.9-0.9-0.6-0.7-0.7-0.8-0.5-0.50.5-1.3
Patch foraging water rate 12 sec0.81.22.4-1.31.31.3-1.1-1.2-0.9-0.8-0.8-1.1-0.7-0.90.9-1.5
Patch foraging water rate 18 sec0.40.53.50.00.30.20.10.00.80.50.50.10.80.6-0.6-1.9
Patch foraging water rate 24 sec1.11.58.6-1.31.61.5-1.1-1.3-0.4-0.5-0.5-0.6-0.5-0.40.4-2.9
Patch foraging water rate 6 sec0.40.61.20.6-0.4-0.40.70.71.10.90.90.51.00.8-0.8-1.0
Seeking ratio, delayed vs. immediate footshock0.91.02.01.1-1.3-1.21.11.20.80.80.81.20.50.5-0.51.4
Distance traveled before self-admin0.80.91.21.1-1.0-1.11.01.01.01.01.00.50.80.8-0.80.8
Distance traveled after self-admin0.10.10.30.4-0.5-0.50.40.30.30.30.40.40.30.2-0.20.5
Extensor digitorum longus weight5.019.524.6-4.95.04.9-4.7-4.8-4.3-4.3-4.3-3.8-4.1-4.14.1-3.9
Bone: elastic displacement0.00.00.1-0.2-0.0-0.0-0.0-0.0-0.3-0.1-0.1-0.3-0.1-0.10.10.2
Bone: elastic work0.91.22.0-1.00.80.9-1.0-0.9-1.3-1.1-1.1-1.1-1.4-1.31.30.2
Bone: endosteal estimation0.91.93.0-1.41.11.2-1.4-1.2-1.7-1.6-1.6-1.6-1.5-1.41.40.1
Bone: endosteal perimeter0.10.32.00.5-0.6-0.60.40.5-0.00.10.1-0.0-0.4-0.20.21.4
Epididymis fat weight0.10.20.40.5-0.3-0.40.50.50.60.60.6-0.00.0-0.10.1-0.2
Delta time in closed arm before/after self-admin0.90.95.6-1.01.21.2-0.8-0.9-0.3-0.3-0.3-0.6-0.3-0.10.1-2.4
Delta time in open arm before/after self-admin1.11.11.9-0.90.91.0-1.1-0.9-1.0-1.2-1.2-1.4-1.0-1.11.1-0.2
Diff in mean of infusions in LGA sessions2.02.22.71.6-1.5-1.51.61.51.61.61.61.41.31.5-1.50.7
Delay discount exponential model param0.00.00.1-0.00.10.1-0.00.00.2-0.1-0.2-0.10.0-0.00.0-0.3
Extinction: sum of active levers before priming3.53.55.21.9-1.6-1.71.91.92.32.22.21.42.02.0-2.0-0.1
Active lever presses in extinction session 61.21.11.71.3-1.2-1.21.21.11.21.11.10.40.90.9-0.90.9
Bone: final force3.25.16.6-2.11.92.0-2.3-2.2-2.6-2.5-2.5-2.3-2.5-2.62.60.0
Bone: final moment3.04.96.5-2.01.92.0-2.2-2.1-2.5-2.5-2.5-2.3-2.5-2.62.60.1
Food consumed during 24 hour testing period0.60.71.3-0.70.80.8-0.8-0.8-0.7-0.7-0.7-1.1-0.9-1.11.1-0.4
Glucose1.82.63.1-1.71.81.8-1.8-1.7-1.6-1.7-1.7-1.7-1.5-1.61.6-1.0
Heart weight0.00.10.3-0.40.30.3-0.2-0.1-0.2-0.1-0.1-0.00.0-0.10.1-0.5
Delay discount hyperbolic model param0.00.00.10.2-0.1-0.10.20.20.40.10.00.10.20.2-0.2-0.3
Intermittent access intake day 1-15 change0.20.20.70.4-0.3-0.30.40.40.50.40.40.30.80.8-0.8-0.1
Intermittent access intake escalation0.40.41.10.10.1-0.00.20.20.60.50.50.11.11.0-1.0-1.1
Intermittent access intake escalation 20.90.82.10.6-0.5-0.50.70.61.01.01.00.61.41.3-1.3-0.6
Intermitt. access day 1 inactive lever presses0.20.21.2-0.00.20.10.10.10.50.50.50.10.30.3-0.3-1.1
Intermitt. access day 15 inactive lever presses0.91.01.50.9-0.7-0.80.90.91.21.21.21.21.11.2-1.2-0.3
Intermitt. access escalation Index0.20.21.60.2-0.3-0.2-0.00.1-0.3-0.4-0.40.3-0.4-0.40.41.3
Intermittent access day 1 total infusions0.60.71.7-0.70.60.6-0.7-0.7-0.8-0.8-0.8-0.5-1.3-1.31.3-0.0
Intermittent access day 15 total infusions0.20.20.3-0.50.60.6-0.5-0.5-0.4-0.4-0.4-0.4-0.5-0.50.5-0.6
Intermittent access terminal intake (last 3 days)0.40.40.7-0.50.50.5-0.6-0.6-0.7-0.8-0.8-0.4-0.7-0.80.80.2
Intermittent access total infusions0.60.61.0-0.80.80.8-0.8-0.8-0.8-0.8-0.8-0.6-1.0-1.01.0-0.4
Intermittent access day 1 locomotion0.00.00.0-0.00.00.0-0.00.00.00.00.00.1-0.1-0.10.1-0.2
Intermittent access day 15 total locomotion0.50.51.20.5-0.5-0.50.50.50.60.50.51.01.11.1-1.10.1
Intermittent access total locomotion0.20.30.50.5-0.5-0.50.50.50.40.40.40.70.60.6-0.60.4
Intermittent access standard deviation0.10.10.50.2-0.1-0.10.20.30.40.30.30.10.70.6-0.6-0.3
Left kidney weight0.10.31.5-0.40.10.2-0.5-0.3-0.9-0.8-0.8-0.2-0.20.0-0.01.2
Right kidney weight0.30.71.40.7-0.8-0.80.70.90.50.50.40.91.01.2-1.21.1
Cocaine induced anxiety1.41.63.21.5-1.6-1.51.31.41.11.11.11.30.90.9-0.91.8
Post-drug Anxiety0.40.53.60.7-0.8-0.80.50.60.10.10.10.4-0.1-0.20.21.9
Baseline Anxiety0.00.00.2-0.10.20.1-0.1-0.1-0.0-0.0-0.0-0.10.10.2-0.2-0.4
Tail length5.316.219.54.1-3.9-4.04.14.14.44.14.14.44.44.2-4.21.5
Length with tail1.97.09.22.8-2.7-2.72.72.82.72.52.53.02.72.7-2.71.7
Length without tail0.10.30.7-0.50.20.3-0.5-0.4-0.8-0.7-0.7-0.5-0.5-0.30.30.7
Times rat made contact with spout1.01.11.5-1.21.21.2-1.1-1.1-0.9-0.9-0.9-1.1-1.1-0.80.8-1.2
Lifetime Intake1.51.72.6-1.21.11.2-1.3-1.3-1.4-1.4-1.4-1.0-1.6-1.61.6-0.2
Liver weight, left1.72.73.4-1.71.81.8-1.7-1.7-1.4-1.5-1.5-1.8-1.6-1.71.7-1.5
Liver weight, right0.81.41.9-1.41.31.3-1.3-1.4-1.4-1.3-1.3-1.0-0.9-0.90.9-0.6
Locomotor activity3.96.39.22.8-2.6-2.62.42.62.42.12.13.02.32.6-2.62.3
Locomotor testing distance1.42.33.71.7-1.6-1.61.51.61.51.31.31.91.31.5-1.51.4
Locomotor testing rearing0.00.10.20.2-0.0-0.10.10.10.40.30.30.50.10.2-0.2-0.3
Locomotion in novel chamber0.40.50.7-0.70.70.7-0.7-0.7-0.7-0.6-0.6-0.7-0.8-0.70.7-0.4
Locomotion in novel chamber post-restriction3.34.05.02.2-2.1-2.12.12.12.22.12.11.61.91.9-1.91.1
Fecal boli incidents, locomotor time 10.50.61.9-0.90.90.9-0.7-0.8-0.6-0.4-0.4-0.8-0.4-0.40.4-1.4
Change in fecal boli incidents, locomotor task0.60.62.50.8-0.9-0.80.60.80.40.10.00.90.50.5-0.51.6
Time >=10cm from walls, locomotor time 10.80.81.4-0.80.60.7-0.8-0.8-1.1-1.0-0.9-1.2-1.0-1.01.00.5
Bouts of movement, locomotor time 10.50.51.00.6-0.7-0.70.80.70.70.91.00.70.60.6-0.60.2
Total resting periods, locomotor time 11.21.31.91.1-1.2-1.21.21.21.11.31.41.31.11.1-1.10.6
Rest time, locomotor task time 10.50.61.00.7-0.9-0.80.80.80.60.70.81.00.70.7-0.70.8
Distance moved, locomotor task time 11.01.12.0-0.70.80.8-1.0-0.9-1.1-1.3-1.4-1.1-1.2-1.11.10.5
Vertical activity count, locomotor time 11.31.41.8-1.11.31.3-1.3-1.3-1.0-1.3-1.3-1.2-1.1-1.11.1-0.9
Time >=10cm from walls, locomotor time 21.41.42.8-1.31.31.3-1.2-1.2-1.1-1.0-0.9-1.7-1.1-1.21.2-1.1
Bouts of movement, locomotor time 20.30.31.60.6-0.7-0.70.50.50.30.40.60.20.1-0.00.01.3
Total resting periods, locomotor time 20.30.31.90.6-0.7-0.60.40.50.20.30.40.30.1-0.00.01.4
Rest time, locomotor task time 20.10.10.90.3-0.4-0.40.20.3-0.00.00.00.50.0-0.00.00.9
Distance moved, locomotor task time 20.10.20.9-0.20.40.4-0.2-0.30.1-0.1-0.1-0.7-0.3-0.30.3-0.9
Vertical activity count, locomotor time 21.41.53.2-1.21.41.4-1.2-1.3-0.7-0.9-0.9-1.4-1.1-1.11.1-1.8
Light reinforcement 13.35.97.52.7-2.6-2.62.62.72.52.42.42.42.12.3-2.31.8
Light reinforcement 20.81.01.61.2-1.1-1.11.11.11.21.11.10.80.70.9-0.90.7
Bone: marrow area0.81.72.7-1.31.11.1-1.3-1.1-1.6-1.5-1.5-1.5-1.3-1.31.30.1
Bone: maximum diameter0.20.43.30.6-0.8-0.70.40.6-0.0-0.0-0.00.5-0.10.1-0.11.8
Bone: maximum force3.45.97.6-2.32.12.2-2.4-2.3-2.7-2.7-2.7-2.5-2.7-2.82.8-0.2
Bone: maximum moment3.45.87.5-2.32.12.2-2.4-2.3-2.7-2.6-2.6-2.5-2.7-2.72.7-0.1
Mean time between licks in bursts0.60.81.31.0-0.9-0.91.01.01.21.11.10.70.90.5-0.5-0.1
Mean num. licks in bursts0.81.01.21.0-1.1-1.11.01.10.80.90.91.11.01.0-1.01.0
Cd content in liver0.50.61.3-0.60.80.7-0.7-0.6-0.6-0.6-0.6-1.1-0.9-0.90.9-0.5
Co content in liver1.41.62.61.2-1.1-1.11.21.21.41.31.31.61.51.5-1.50.0
Cu content in liver1.62.03.1-1.11.11.1-1.4-1.3-1.5-1.6-1.6-1.2-1.8-1.71.70.6
Fe content in liver0.50.61.0-0.90.90.9-0.8-0.8-0.6-0.6-0.6-0.9-0.7-0.70.7-1.0
K content in liver0.40.41.50.7-0.8-0.80.60.70.40.50.50.30.30.3-0.31.2
Mg content in liver0.30.31.90.6-0.7-0.70.50.60.10.30.30.10.10.1-0.11.4
Mn content in liver0.60.76.30.6-0.9-0.80.40.6-0.2-0.1-0.1-0.2-0.3-0.30.32.5
Na content in liver0.10.10.3-0.20.10.1-0.2-0.3-0.4-0.3-0.3-0.4-0.5-0.50.50.5
Rb content in liver1.01.21.9-0.90.80.8-1.1-1.0-1.3-1.3-1.3-1.1-1.4-1.41.40.6
Se content in liver0.00.00.10.1-0.3-0.30.20.20.00.20.20.20.00.0-0.00.3
Sr content in liver0.40.30.90.2-0.2-0.20.40.30.60.50.50.50.80.8-0.8-1.0
Zn content in liver2.62.84.01.4-1.2-1.31.61.42.01.91.91.72.02.0-2.0-0.8
Bone: minimum diameter0.40.81.4-0.70.50.6-0.8-0.7-1.2-1.1-1.1-0.8-1.1-1.11.10.8
Time in familiar zone, hab. session 15.14.86.52.4-2.2-2.32.42.32.62.52.51.82.02.0-2.00.7
Time in novel zone, hab. session 13.93.85.3-1.91.71.8-2.1-2.0-2.3-2.3-2.3-1.8-2.0-2.02.00.1
Total zone transitions, hab. session 10.40.62.91.0-1.0-0.90.70.80.50.40.40.60.30.3-0.31.7
Total locomotion distance, hab. session 11.52.27.71.8-1.8-1.71.31.61.10.90.91.30.91.0-1.02.8
Locomotion velocity, hab. session 11.72.46.01.9-1.9-1.81.51.71.31.11.11.51.11.2-1.22.4
Time in familiar zone, hab. session 24.95.16.62.2-2.1-2.22.42.32.52.62.62.32.32.3-2.30.4
Time in novel zone, hab. session 25.85.87.5-2.32.22.3-2.5-2.4-2.7-2.7-2.7-2.4-2.5-2.52.5-0.2
Total zone transitions, hab. session 20.60.81.6-0.40.40.5-0.8-0.7-1.0-1.2-1.2-0.5-1.1-1.11.11.3
Total locomotion distance, hab. session 20.40.52.40.8-0.9-0.80.60.70.40.30.31.00.40.4-0.41.5
Locomotion velocity, hab. session 20.50.73.50.9-1.0-0.90.60.70.40.30.31.00.40.4-0.41.9
Novel to familiar place preference ratio2.93.04.4-1.31.51.6-1.8-1.7-1.7-2.1-2.1-1.7-2.0-2.02.00.4
Novelty place preference2.02.13.0-1.01.21.2-1.5-1.4-1.4-1.7-1.7-1.5-1.7-1.71.70.5
Time in novel zone, NPP test2.72.83.9-1.21.41.5-1.8-1.6-1.6-2.0-2.0-1.7-1.9-1.91.90.3
Total zone transitions, NPP test0.30.40.8-0.40.40.4-0.6-0.5-0.7-0.8-0.8-0.6-0.9-0.90.90.6
Total locomotion distance, NPP test0.10.21.3-0.0-0.1-0.0-0.2-0.1-0.4-0.5-0.50.1-0.4-0.40.41.1
Locomotion velocity, NPP test0.10.21.60.3-0.4-0.40.20.3-0.1-0.1-0.10.4-0.0-0.00.01.3
Intraocular pressure0.50.81.40.7-0.6-0.70.90.81.11.21.20.90.60.9-0.9-0.7
Delta distance traveled before/after self-admin0.10.10.3-0.20.20.2-0.2-0.3-0.3-0.3-0.30.5-0.2-0.20.20.1
Delta ambulatory time before/after self-admin0.10.10.2-0.20.10.2-0.3-0.3-0.4-0.4-0.40.3-0.4-0.40.40.5
Parametrial fat weight0.00.10.10.2-0.1-0.20.30.20.30.30.4-0.2-0.20.3-0.3-0.3
Pavlov. Cond. lever latency0.20.21.6-0.40.40.4-0.1-0.20.10.10.1-0.6-0.0-0.00.0-1.3
Pavlov. Cond. magazine entry latency1.62.12.41.4-1.4-1.41.51.51.51.51.51.61.51.5-1.50.6
Pavlov. Cond. change in total contacts0.20.20.3-0.30.40.5-0.5-0.4-0.4-0.6-0.6-0.4-0.5-0.50.5-0.1
Pavlov. Cond. index score0.50.61.30.9-0.9-0.90.70.80.60.50.51.00.60.6-0.61.1
Pavlov. Cond. latency score0.50.72.20.9-1.0-0.90.70.80.60.40.41.00.60.6-0.61.5
Pavlov. Cond. lever contacts0.20.22.10.3-0.4-0.30.00.2-0.2-0.3-0.30.4-0.2-0.10.11.5
Pavlov. Cond. magazine entry number0.60.70.8-0.80.90.9-0.9-0.9-0.8-0.8-0.8-0.9-0.9-0.90.9-0.5
Pavlov. Cond. intertrial magazine entries0.10.20.50.3-0.1-0.10.30.20.60.40.40.30.50.5-0.5-0.7
Pavlov. Cond. lever-magazine prob. diff.0.60.71.31.0-1.0-0.90.80.90.70.60.61.00.70.7-0.71.1
Pavlov. Cond. response bias0.80.91.21.1-1.0-1.01.01.01.00.90.91.00.90.9-0.90.7
Pavlov. Cond. lever latency1.72.32.7-1.61.61.6-1.6-1.6-1.6-1.5-1.5-1.5-1.6-1.51.5-0.9
Pavlov. Cond. magazine entry latency2.22.63.41.8-1.8-1.81.71.71.71.61.61.51.51.3-1.31.1
Pavlov. Cond. change in total contacts0.60.81.21.1-1.0-1.01.01.01.11.01.00.71.00.6-0.60.4
Pavlov. Cond. index score2.02.53.21.8-1.7-1.71.71.71.81.71.71.41.61.4-1.40.9
Pavlov. Cond. latency score2.12.63.41.9-1.8-1.81.71.81.71.71.71.51.61.4-1.41.1
Pavlov. Cond. lever contacts1.41.92.41.5-1.4-1.41.51.41.61.51.51.41.51.4-1.40.5
Pavlov. Cond. magazine entry number1.92.33.1-1.81.71.7-1.6-1.7-1.6-1.5-1.5-1.4-1.5-1.21.2-1.1
Pavlov. Cond. intertrial magazine entries0.60.71.3-1.01.11.1-1.0-1.0-0.7-0.9-0.9-0.3-0.4-0.40.4-1.1
Pavlov. Cond. lever-magazine prob. diff.2.02.53.21.8-1.7-1.71.71.71.71.61.61.51.61.4-1.41.0
Pavlov. Cond. response bias2.12.93.51.8-1.7-1.71.81.81.91.81.81.71.81.6-1.60.6
Time in closed arm before self-admin0.30.41.0-0.30.10.1-0.4-0.3-0.8-0.7-0.70.2-0.7-0.80.81.0
Time in closed arm after self-admin0.40.40.6-0.80.60.6-0.7-0.7-0.8-0.7-0.70.3-0.5-0.40.4-0.2
Time in open arm before self-admin0.20.20.30.4-0.2-0.30.40.30.50.60.5-0.50.40.5-0.5-0.4
Time in open arm after self-admin1.31.46.1-1.01.21.2-1.1-1.1-0.8-0.9-0.9-2.5-0.9-0.90.9-1.1
Bone: periosteal estimation1.53.14.9-1.61.31.4-1.7-1.5-2.2-2.1-2.1-1.7-2.1-2.02.00.7
Bone: periosteal perimeter0.30.51.9-0.1-0.00.1-0.4-0.3-0.8-0.7-0.7-0.5-1.1-0.90.91.4
Bone: post-yield work0.30.40.7-0.80.70.7-0.8-0.7-0.8-0.8-0.8-0.4-0.2-0.40.4-0.3
Progressive ratio test 1 active lever presses1.61.72.0-1.31.31.3-1.3-1.3-1.3-1.3-1.3-1.1-1.4-1.41.4-0.8
Progressive ratio test 1 breakpoint1.81.92.5-1.41.31.4-1.4-1.3-1.4-1.4-1.4-1.2-1.5-1.61.6-0.7
Progressive ratio test 1 inactive lever presses0.10.10.1-0.20.10.2-0.2-0.2-0.3-0.4-0.40.1-0.3-0.30.30.2
Progressive ratio test 2 active lever presses0.60.70.9-0.90.80.8-0.9-0.9-1.0-1.0-1.0-0.5-0.7-0.80.8-0.3
Progressive ratio test 2 breakpoint0.30.30.6-0.50.30.4-0.5-0.5-0.7-0.8-0.8-0.1-0.6-0.60.60.4
Progressive ratio test 2 inactive lever presses0.50.61.2-0.60.60.6-0.7-0.7-0.9-0.9-0.9-0.4-1.1-1.11.10.2
Incentive Sensitization - Responses0.10.10.30.2-0.3-0.30.20.20.20.20.20.50.50.4-0.40.3
Incentive Sensitization - Breakpoint0.10.10.40.3-0.4-0.40.30.30.20.20.20.60.50.4-0.40.5
Sum of active levers in priming session hrs 5-60.30.30.50.7-0.5-0.50.60.50.70.60.60.10.30.3-0.30.1
Progressive ratio1.11.21.7-1.31.31.3-1.2-1.2-1.1-1.2-1.2-1.0-0.7-0.80.8-1.0
Food seeking constrained by brief footshock1.82.33.01.7-1.6-1.61.61.61.71.71.71.31.41.4-1.40.8
Seeking ratio, punishment vs. effort2.42.93.71.9-1.9-1.91.91.91.91.91.91.51.41.5-1.51.0
Retroperitoneal fat weight2.37.59.1-2.93.03.0-3.0-2.8-2.7-2.8-2.8-2.5-2.7-2.62.6-2.0
Reaction time number correct0.91.22.6-1.21.31.3-1.1-1.2-0.8-0.7-0.7-1.5-1.0-0.80.8-1.6
Reaction time mean minus median1.92.55.71.6-1.6-1.61.51.61.51.31.32.41.61.5-1.51.1
Reaction time mean minus median AUC1.82.35.11.6-1.8-1.71.41.61.10.90.92.31.21.2-1.22.2
Reaction time num false alarms0.40.50.9-0.80.90.9-0.9-0.9-0.7-0.8-0.8-0.7-0.4-0.30.3-0.8
Reaction time num false alarms AUC0.50.61.3-0.91.01.0-0.9-0.9-0.6-0.8-0.8-0.7-0.3-0.20.2-1.1
Reaction time trials correct on left0.91.22.6-1.21.31.3-1.1-1.2-0.8-0.7-0.7-1.5-1.0-0.80.8-1.6
Reaction time trials on left0.81.22.3-1.11.31.2-1.0-1.1-0.8-0.7-0.7-1.4-1.0-0.90.9-1.5
Reaction time mean1.11.52.71.3-1.5-1.51.31.40.91.01.01.51.20.8-0.81.6
Reaction time mean AUC0.50.61.90.8-1.0-1.00.80.80.40.50.51.00.70.3-0.31.4
Median of all reaction times0.50.71.80.8-1.0-1.00.80.90.50.70.70.80.70.3-0.31.3
Reaction time omissions0.10.10.4-0.1-0.00.0-0.1-0.1-0.2-0.2-0.20.0-0.3-0.60.60.4
Reaction time false alarm rate0.10.10.2-0.30.30.3-0.4-0.3-0.3-0.5-0.50.00.10.1-0.1-0.0
Reaction time premature initiation rate1.82.33.21.3-1.3-1.31.51.51.71.81.81.81.61.7-1.7-0.1
Reaction time premature initiations0.81.11.90.7-0.6-0.61.00.81.31.41.40.91.01.2-1.2-1.1
Std. dev. reaction times0.91.32.71.2-1.3-1.21.11.20.90.90.91.61.11.0-1.01.3
Reaction time trials completed0.81.22.3-1.11.31.2-1.0-1.1-0.8-0.7-0.7-1.4-1.0-0.90.9-1.5
Reaction time trials AUC1.01.43.2-1.21.41.3-1.1-1.2-0.8-0.7-0.7-1.6-1.1-0.90.9-1.8
Run reversals in cocaine runway, females1.71.72.21.5-1.5-1.51.41.31.31.31.31.31.01.1-1.11.2
Run reversals in cocaine runway, males2.32.32.71.6-1.7-1.61.51.51.31.31.31.51.61.5-1.51.5
Latency to leave start box in cocaine runway0.30.31.6-0.2-0.00.1-0.4-0.2-0.7-0.8-0.8-0.0-0.6-0.50.51.3
Latency to leave start box in cocaine runway, F0.60.73.0-0.20.00.1-0.5-0.3-1.0-1.0-1.0-0.3-0.9-0.80.81.7
Latency to leave start box in cocaine runway, M0.10.10.7-0.10.20.2-0.0-0.00.20.10.10.40.20.2-0.2-0.8
Std. dev. time between licks in bursts0.30.41.80.8-0.8-0.70.60.60.50.30.30.40.40.4-0.41.3
Total sessions with >9 infusions1.01.12.1-0.60.50.6-0.8-0.8-1.2-1.3-1.3-0.9-1.4-1.41.41.0
Short access day 1 total inactive lever presses0.10.10.2-0.20.20.2-0.2-0.2-0.3-0.3-0.3-0.0-0.4-0.40.40.1
Short access day 10 total inactive lever presses0.10.10.7-0.30.30.2-0.1-0.10.10.10.10.30.30.4-0.4-0.8
Short access day 1 total infusions1.71.83.1-1.10.91.0-1.3-1.2-1.7-1.8-1.8-0.8-1.6-1.61.60.9
Short access day 10 total infusions1.21.32.1-1.11.01.1-1.1-1.1-1.2-1.2-1.2-0.9-1.4-1.41.4-0.3
Short access total infusions2.62.94.5-1.51.31.4-1.7-1.6-2.0-2.0-2.0-1.3-2.1-2.12.10.4
Short access day 1 locomotion0.10.10.50.1-0.2-0.20.00.1-0.1-0.2-0.20.40.20.3-0.30.7
Short access day 10 total locomotion1.51.72.91.0-1.1-1.11.31.21.31.41.41.21.71.7-1.70.0
Short access total locomotion0.10.10.20.3-0.4-0.40.30.40.20.20.20.40.30.4-0.40.5
One hour access (0.3 mA shock)0.60.71.0-0.90.70.8-0.8-0.8-0.9-0.8-0.8-0.6-1.0-1.01.0-0.3
Compulsive drug intake0.20.20.3-0.50.40.4-0.4-0.5-0.6-0.5-0.5-0.2-0.5-0.50.5-0.0
One hour access (shock baseline)0.20.20.6-0.50.60.5-0.4-0.4-0.2-0.2-0.2-0.7-0.5-0.50.5-0.8
Social response proportion1.01.11.51.0-1.2-1.21.11.00.81.01.01.11.11.0-1.01.1
Social responses9.311.914.43.7-3.8-3.83.63.63.23.33.33.53.43.3-3.32.9
Social time0.70.91.4-1.21.21.2-1.2-1.1-1.0-1.1-1.1-0.6-0.4-0.40.4-1.0
Soleus weight5.616.519.9-4.54.44.4-4.4-4.4-4.3-4.3-4.3-3.3-3.8-3.83.8-2.5
Bone: stiffness4.97.79.4-2.72.72.7-2.9-2.8-3.0-3.1-3.1-2.7-3.0-3.03.0-0.7
Tibialis anterior weight1.13.84.6-2.12.12.1-2.1-1.9-2.0-2.1-2.1-1.7-1.9-1.91.9-1.2
Time to tail flick, vehicle, before self-admin1.31.44.91.1-1.4-1.31.01.10.50.50.62.00.60.5-0.52.2
Time to tail flick, vehicle, after self-admin0.30.40.70.5-0.4-0.40.60.60.80.80.80.40.60.5-0.5-0.6
Time to tail flick, test, before self-admin1.01.02.81.0-1.2-1.10.91.00.60.60.51.20.90.9-0.91.7
Time to tail flick, test, after self-admin0.20.21.30.3-0.4-0.30.10.3-0.1-0.1-0.1-0.3-0.4-0.50.51.1
Delta time to tail flick, vehicle, before/after SA0.80.84.1-0.81.01.0-0.6-0.7-0.2-0.2-0.2-1.4-0.5-0.50.5-2.0
Delta time to tail flick, test, before/after SA0.10.10.30.2-0.1-0.20.30.20.50.50.6-0.3-0.0-0.10.1-0.6
Tibia length1.33.74.81.9-1.8-1.81.91.92.01.92.02.22.12.1-2.10.7
Ambulatory time before self-admin0.20.20.30.6-0.5-0.50.50.50.50.50.5-0.20.10.0-0.00.4
Ambulatory time after self-admin0.00.00.10.2-0.2-0.20.10.00.10.10.10.1-0.2-0.20.20.3
Bone: tissue strength5.35.26.5-2.42.12.2-2.2-2.2-2.5-2.3-2.3-2.6-2.5-2.52.5-0.8
Total heroin consumption2.12.53.61.9-1.8-1.81.81.81.71.71.71.11.21.2-1.21.3
Bone: trabecular number0.71.04.51.1-1.3-1.20.91.00.50.50.50.90.80.6-0.62.1
Bone: trabecular spacing0.50.76.3-0.70.90.8-0.3-0.50.20.30.3-0.40.00.1-0.1-2.5
Bone: trabecular thickness1.11.38.60.1-0.3-0.1-0.5-0.2-1.1-1.3-1.3-0.3-0.8-1.01.02.9
Bone: trabecular tissue density5.67.99.8-3.13.13.1-3.0-3.1-2.7-2.7-2.7-2.4-2.7-2.62.6-2.5
Water consumed over 24 hours1.11.42.1-1.00.90.9-1.1-1.1-1.3-1.3-1.3-1.2-1.5-1.41.40.5
Number of responses in last shaping day0.80.81.60.9-0.9-0.90.80.90.80.70.71.31.01.0-1.00.6