Hub : Genes

Ptchd3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	gene expression	Ptchd3	0.31	0.18	7.9e-03	-0.01	-0.02	-0.02	-0.02	5.2e-01	8.6e-01	9.3e-01	9.7e-01
2	Liver	gene expression	Ptchd3	0.22	0.07	0.0e+00	0.2	0.21	0.21	0.21	3.3e-22	5.0e-23	1.6e-22	8.8e-23
3	Adipose	alternative TSS	XM_039087577.2	0.22	0.1	1.3e-12	0.13	0.1	0.09	0.13	1.6e-14	1.3e-11	1.6e-10	6.2e-14
4	Adipose	gene expression	Ptchd3	0.33	0.08	0.0e+00	0.32	0.34	0.33	0.34	4.5e-36	3.4e-38	1.4e-37	1.4e-38

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.1	0.2	-0.5	-0.2	0.1	-0.3
Area under the delay curve	0.9	1.1	3.8	1.9	0.6	-0.4	0.4
BMI with tail	0.9	3.2	6.9	-2.6	-1.0	1.7	-1.3
BMI without tail	2.2	6.7	9.3	-3.1	-2.6	2.5	-2.2
Body weight	2.4	10.6	22.7	-4.8	-2.4	2.9	-2.4
Weight adjusted by age	1.2	1.8	5.7	-2.4	-0.6	0.7	-0.7
Bone surface	0.5	0.8	1.2	-1.1	-0.9	0.8	-0.9
Bone volume	0.3	0.5	1.0	-1.0	-0.7	0.5	-0.6
Breakpoint value in progressive ratio session	0.5	0.6	1.0	-0.8	-0.5	1.0	-0.7
Number of licking bursts	0.1	0.1	0.2	0.0	-0.5	0.2	-0.4
Context. condit. distance diff. score	1.7	2.0	2.7	-0.9	-1.6	1.4	-1.6
Locomotion velocity, session 1	4.0	4.3	5.5	1.3	2.3	-2.2	2.3
Locomotion distance, session 1	0.2	0.2	0.4	0.7	-0.0	0.4	-0.5
Locomotion velocity, session 2	1.4	1.6	4.6	2.1	1.0	-0.8	0.6
Locomotion distance, session 2	0.3	0.5	0.7	0.4	-0.7	0.8	-0.8
Locomotion velocity, session 3	2.4	2.8	5.4	2.3	1.5	-1.3	1.2
Locomotion distance, session 3	2.0	2.1	6.1	2.5	1.2	-0.8	0.7
Stereotopy head waving bouts, day 3	0.2	0.3	0.6	0.0	0.8	-0.5	0.6
Stereotopy head waving duration, day 3	0.0	0.0	0.2	-0.4	0.1	0.1	-0.1
Locomotion velocity, session 7	0.2	0.2	0.7	0.9	-0.0	0.1	-0.2
Locomotion distance, session 7	0.9	1.2	4.7	2.2	0.0	-0.0	-0.2
Stereotopy head waving bouts, day 7	1.6	1.9	3.4	-1.8	-1.1	1.3	-1.1
Stereotopy head waving duration, day 7	0.8	1.0	2.0	-1.4	-0.7	0.8	-0.8
Locomotion velocity, session 8	0.2	0.2	0.7	0.8	0.1	0.1	-0.3
Locomotion distance, session 8	3.6	5.2	7.1	-0.8	-2.6	2.6	-2.7
Degree of sensitization distance	0.2	0.2	0.5	-0.4	-0.7	0.3	-0.4
Degree of sensitization stereotypy	1.4	1.6	2.3	-1.5	-1.1	1.2	-1.1
Conditioned locomotion	2.2	2.5	4.2	-2.0	-1.6	1.3	-1.3
Cocaine response after cond. corrected	0.8	0.9	1.2	0.7	1.1	-0.9	1.0
Cocaine response after cond. not corrected	0.6	0.7	1.1	1.0	0.9	-0.6	0.7
Cocaine response before conditioning	0.8	0.9	1.3	0.6	-0.9	1.1	-1.1
Saline control response	0.2	0.2	0.5	0.3	0.1	-0.7	0.5
Bone: connectivity density	0.1	0.1	0.3	0.2	-0.4	0.2	-0.5
Bone: cortical apparent density	3.2	4.4	8.5	2.9	1.9	-1.8	1.6
Bone: cortical area	3.6	5.5	15.4	-3.9	-1.3	1.8	-1.3
Bone: cortical porosity	0.8	0.8	3.1	-1.8	-0.1	0.3	0.2
Bone: cortical porosity	0.7	0.8	3.0	-1.7	-0.1	0.2	0.2
Bone: cortical thickness	1.4	2.3	8.9	-3.0	0.4	0.1	0.4
Bone: cortical thickness	0.6	0.7	1.8	-1.3	0.7	-0.4	0.7
Bone: cortical tissue density	3.8	5.1	9.3	3.0	2.0	-2.0	1.8
Condit. Reinf. active minus inactive responses	0.6	0.6	2.0	-1.4	-0.5	0.4	-0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.5	0.2	-0.1	0.0
Condit. Reinf. active responses	1.5	1.9	4.5	-2.1	-1.2	0.9	-0.8
Condit. Reinf. inactive responses	0.6	0.8	1.6	-1.3	-1.0	0.6	-0.5
Incentive salience index mean	0.8	1.0	2.2	-1.5	-0.9	0.8	-0.7
Condit. Reinf. lever presses	0.4	0.6	0.8	-0.4	-0.9	0.8	-0.8
Condit. Reinf. active minus inactive responses	0.6	0.7	2.2	-1.5	-0.3	0.6	-0.5
Condit. Reinf. active-inactive response ratio	1.1	1.3	5.0	-2.2	-0.1	0.3	-0.0
Condit. Reinf. active responses	0.3	0.4	0.5	-0.7	-0.4	0.6	-0.6
Condit. Reinf. inactive responses	0.3	0.4	1.5	1.2	-0.0	-0.0	-0.3
Condit. Reinf. lever presses	0.3	0.4	0.7	-0.2	-0.8	0.6	-0.6
Condit. Reinf. lever reinforcers received	0.7	1.0	1.1	-1.0	-0.9	1.0	-1.0
Conditioned reinforcement - actives	0.1	0.2	0.4	0.4	-0.6	0.4	-0.3
Conditioned reinforcement - inactives	0.1	0.1	0.3	0.1	-0.4	0.6	-0.1
Conditioned locomotion	0.9	1.2	2.4	0.0	-1.5	1.1	-1.1
Patch foraging indifference point 0 sec	0.2	0.3	0.7	0.8	0.4	-0.5	0.4
Patch foraging indifference point AUC	0.0	0.0	0.1	0.1	-0.2	-0.2	0.3
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	0.3	0.4	-0.2	0.3
Delay disc. indifference point, 16s delay	0.9	1.0	1.6	1.3	-0.7	0.9	-0.9
Delay disc. indifference point, 2s delay	0.0	0.0	0.2	0.4	0.1	0.1	-0.0
Delay disc. indifference point, 24s delay	2.1	2.4	5.5	2.3	1.4	-0.9	1.1
Delay disc. indifference point, 4s delay	2.5	2.7	4.5	2.1	1.4	-1.5	1.4
Delay disc. indifference point, 8s delay	1.7	2.0	3.1	1.8	1.5	-1.1	1.2
Indifference point function ln k	0.3	0.5	1.2	1.1	0.8	-0.4	0.2
Indifference point function log k	0.3	0.5	1.2	1.1	0.8	-0.4	0.2
Patch foraging total patch changes 0 sec	0.1	0.3	0.6	0.8	0.3	-0.5	0.4
Patch foraging total patch changes 12 sec	0.2	0.2	0.5	0.3	0.2	-0.5	0.7
Patch foraging total patch changes 18 sec	0.1	0.2	0.6	0.7	-0.3	-0.0	-0.2
Patch foraging total patch changes 24 sec	0.1	0.2	0.3	0.3	0.2	-0.6	0.5
Patch foraging total patch changes 6 sec	0.1	0.1	0.3	0.0	0.1	-0.3	0.5
Patch foraging time to switch 0 sec	0.0	0.1	0.1	-0.2	-0.2	0.3	-0.3
Patch foraging water rate 0 sec	0.0	0.1	0.4	0.6	-0.1	-0.1	0.0
Patch foraging water rate 12 sec	0.0	0.0	0.0	0.2	0.1	-0.0	0.0
Patch foraging water rate 18 sec	0.4	0.6	0.8	-0.5	-0.8	0.9	-0.9
Patch foraging water rate 24 sec	1.0	1.3	1.9	-0.6	-1.2	1.2	-1.4
Patch foraging water rate 6 sec	0.1	0.1	0.4	0.6	0.2	0.0	0.0
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.3	-0.5	0.1	-0.5	0.2
Distance traveled before self-admin	0.1	0.1	0.2	0.2	0.2	-0.4	0.3
Distance traveled after self-admin	0.8	1.0	2.3	-0.0	-1.5	0.8	-0.9
Extensor digitorum longus weight	0.8	3.3	4.1	-2.0	-1.7	1.8	-1.7
Bone: elastic displacement	0.2	0.2	0.4	-0.5	0.2	-0.5	0.6
Bone: elastic work	2.0	2.7	7.5	-2.7	0.7	-0.9	1.3
Bone: endosteal estimation	3.0	6.6	8.2	-1.9	-2.6	2.8	-2.9
Bone: endosteal perimeter	1.0	2.2	3.6	-1.9	-1.3	1.3	-1.4
Epididymis fat weight	1.4	4.7	6.2	-2.5	-2.1	2.2	-1.9
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	0.0	0.0	-0.1	-0.1
Delta time in open arm before/after self-admin	0.5	0.5	1.0	1.0	0.4	-0.6	0.6
Diff in mean of infusions in LGA sessions	0.2	0.2	0.3	-0.5	-0.5	0.5	-0.5
Delay discount exponential model param	1.8	2.0	5.8	-2.4	-1.0	0.8	-0.8
Extinction: sum of active levers before priming	0.9	1.0	1.8	0.4	1.3	-1.0	1.1
Active lever presses in extinction session 6	0.6	0.6	1.4	0.4	1.2	-0.4	0.7
Bone: final force	4.2	6.7	16.4	-4.0	-1.8	2.2	-1.7
Bone: final moment	4.2	6.8	18.6	-4.3	-1.6	2.0	-1.4
Food consumed during 24 hour testing period	0.0	0.1	0.1	-0.3	-0.0	-0.3	0.2
Glucose	5.4	8.4	13.0	2.0	3.6	-2.7	3.1
Heart weight	1.1	1.8	5.7	-2.4	-0.7	0.9	-0.4
Delay discount hyperbolic model param	1.7	1.9	5.0	-2.2	-1.0	0.8	-0.8
Intermittent access intake day 1-15 change	0.2	0.4	1.2	1.1	0.2	-0.5	0.4
Intermittent access intake escalation	0.5	1.0	2.3	1.5	0.5	-0.9	0.7
Intermittent access intake escalation 2	0.3	0.4	0.9	0.9	0.3	-0.5	0.6
Intermitt. access day 1 inactive lever presses	0.4	1.4	2.3	-0.7	-1.5	1.2	-1.2
Intermitt. access day 15 inactive lever presses	0.4	0.8	1.6	0.1	-1.3	0.8	-0.9
Intermitt. access escalation Index	0.2	0.3	0.7	0.6	0.4	-0.8	0.4
Intermittent access day 1 total infusions	0.5	0.8	1.6	-1.2	-0.9	0.8	-0.5
Intermittent access day 15 total infusions	0.0	0.0	0.1	0.0	-0.3	-0.1	0.1
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	-0.1	-0.3	-0.0	0.1
Intermittent access total infusions	0.0	0.0	0.1	-0.2	-0.4	0.0	0.0
Intermittent access day 1 locomotion	0.0	0.0	0.1	0.3	-0.2	-0.1	-0.0
Intermittent access day 15 total locomotion	0.0	0.1	0.2	-0.2	-0.4	0.2	-0.2
Intermittent access total locomotion	0.0	0.0	0.1	0.3	-0.3	-0.1	0.0
Intermittent access standard deviation	0.4	0.9	1.2	1.1	1.0	-0.7	1.0
Left kidney weight	0.6	2.7	6.7	-2.6	-0.8	1.5	-1.2
Right kidney weight	0.3	1.2	4.1	-2.0	-0.2	0.7	-0.5
Cocaine induced anxiety	1.6	2.3	3.8	0.5	2.0	-1.5	1.8
Post-drug Anxiety	3.0	3.2	4.6	1.2	2.1	-1.8	1.9
Baseline Anxiety	0.1	0.2	0.6	0.7	0.1	-0.2	0.0
Tail length	1.3	5.3	8.4	-2.9	-2.5	1.8	-1.7
Length with tail	0.5	2.2	6.5	-2.5	-0.9	0.9	-0.8
Length without tail	0.3	0.9	1.9	-1.4	1.1	-0.4	0.7
Times rat made contact with spout	0.5	0.6	0.9	-0.6	0.4	-0.9	0.9
Lifetime Intake	0.1	0.1	0.1	0.3	0.1	-0.4	0.4
Liver weight, left	0.1	0.1	0.3	-0.0	-0.1	0.6	-0.4
Liver weight, right	2.9	5.1	6.8	-2.6	-2.2	2.1	-2.1
Locomotor activity	0.1	0.1	0.3	0.1	-0.4	0.5	-0.4
Locomotor testing distance	0.1	0.2	0.4	0.2	-0.4	0.5	-0.6
Locomotor testing rearing	0.2	0.4	1.5	1.2	-0.3	-0.0	-0.1
Locomotion in novel chamber	0.1	0.1	0.3	-0.5	-0.1	0.3	-0.4
Locomotion in novel chamber post-restriction	1.1	1.8	4.1	-2.0	-1.2	1.0	-0.9
Fecal boli incidents, locomotor time 1	1.1	1.6	2.5	-0.6	-1.4	1.6	-1.2
Change in fecal boli incidents, locomotor task	4.1	4.0	4.8	1.7	2.0	-2.2	2.1
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.3	0.5	-0.5	-0.1	-0.4
Bouts of movement, locomotor time 1	0.2	0.3	0.4	0.3	0.6	-0.5	0.6
Total resting periods, locomotor time 1	0.5	0.5	0.7	0.6	0.8	-0.7	0.8
Rest time, locomotor task time 1	0.0	0.0	0.1	-0.3	-0.2	0.1	0.1
Distance moved, locomotor task time 1	0.3	0.4	1.0	1.0	0.5	-0.5	0.3
Vertical activity count, locomotor time 1	0.1	0.2	0.3	-0.2	-0.5	0.3	-0.5
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	-0.3	0.4	-0.2	0.1
Bouts of movement, locomotor time 2	0.0	0.1	0.2	0.2	0.4	-0.0	0.0
Total resting periods, locomotor time 2	0.1	0.2	0.3	-0.3	-0.3	0.6	-0.6
Rest time, locomotor task time 2	0.7	0.9	1.2	-1.0	-1.1	0.8	-0.9
Distance moved, locomotor task time 2	0.8	0.9	1.1	1.0	1.0	-0.9	0.9
Vertical activity count, locomotor time 2	0.3	0.4	0.7	-0.4	-0.6	0.8	-0.7
Light reinforcement 1	0.2	0.5	1.8	-1.3	-0.5	-0.1	-0.2
Light reinforcement 2	0.8	1.3	3.3	-1.8	-0.9	0.7	-0.6
Bone: marrow area	3.0	6.5	8.1	-1.9	-2.6	2.8	-2.8
Bone: maximum diameter	1.7	3.1	6.1	-2.5	-1.3	1.6	-1.4
Bone: maximum force	5.3	9.4	21.3	-4.6	-2.2	2.6	-2.2
Bone: maximum moment	5.3	9.4	23.8	-4.9	-2.0	2.4	-1.9
Mean time between licks in bursts	0.5	1.3	3.2	1.8	0.9	-0.8	0.7
Mean num. licks in bursts	0.2	0.2	0.4	-0.4	0.4	-0.5	0.6
Cd content in liver	0.9	1.0	1.5	0.2	-1.2	1.1	-1.2
Co content in liver	0.0	0.0	0.0	-0.1	0.0	-0.1	-0.0
Cu content in liver	0.7	0.8	1.2	0.1	0.8	-1.1	1.1
Fe content in liver	0.9	1.1	1.8	0.1	-1.0	1.3	-1.3
K content in liver	0.3	0.3	0.5	0.6	-0.7	0.2	-0.6
Mg content in liver	0.8	0.8	1.3	1.1	-1.0	0.5	-0.8
Mn content in liver	0.5	0.5	0.8	0.9	0.5	-0.7	0.7
Na content in liver	0.3	0.4	1.4	1.2	-0.0	-0.1	-0.2
Rb content in liver	0.7	0.8	1.4	-0.7	-1.2	0.7	-0.9
Se content in liver	0.3	0.3	0.6	0.6	0.2	-0.8	0.5
Sr content in liver	2.7	2.3	3.2	0.6	1.6	-1.8	1.8
Zn content in liver	1.6	1.8	2.4	-1.5	-1.4	1.2	-1.1
Bone: minimum diameter	1.3	2.3	7.4	-2.7	-0.9	0.8	-0.7
Time in familiar zone, hab. session 1	0.3	0.3	0.4	0.0	0.6	-0.5	0.7
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.3	0.2	-0.4	0.3
Total zone transitions, hab. session 1	0.0	0.0	0.1	0.2	-0.2	0.3	-0.1
Total locomotion distance, hab. session 1	0.8	1.2	1.5	-1.0	-1.1	1.2	-1.0
Locomotion velocity, hab. session 1	1.4	2.0	2.6	-1.2	-1.5	1.6	-1.4
Time in familiar zone, hab. session 2	0.0	0.0	0.1	0.3	0.1	0.1	0.1
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.3	0.2	-0.4	0.1
Total zone transitions, hab. session 2	0.9	1.2	1.5	-0.7	-1.1	1.2	-1.2
Total locomotion distance, hab. session 2	2.1	2.8	3.0	-1.6	-1.7	1.7	-1.6
Locomotion velocity, hab. session 2	2.3	3.1	3.3	-1.7	-1.8	1.8	-1.7
Novel to familiar place preference ratio	0.7	0.8	1.5	-1.2	0.6	-0.7	0.9
Novelty place preference	0.8	0.9	1.6	-1.3	0.7	-0.8	0.9
Time in novel zone, NPP test	0.7	0.7	1.2	-1.1	0.6	-0.7	0.9
Total zone transitions, NPP test	1.5	2.2	3.2	-0.1	-1.7	1.7	-1.8
Total locomotion distance, NPP test	3.1	4.3	5.5	-1.0	-2.3	2.3	-2.3
Locomotion velocity, NPP test	2.6	3.6	4.6	-1.2	-2.1	2.1	-2.1
Intraocular pressure	2.3	3.4	4.4	-1.2	-2.1	2.0	-1.9
Delta distance traveled before/after self-admin	0.2	0.2	0.5	0.7	-0.5	0.2	-0.1
Delta ambulatory time before/after self-admin	0.1	0.2	0.6	0.7	-0.4	0.0	-0.1
Parametrial fat weight	0.7	1.6	3.3	-1.8	-1.3	0.8	-0.8
Pavlov. Cond. lever latency	1.1	1.4	2.4	0.4	-1.2	1.4	-1.5
Pavlov. Cond. magazine entry latency	0.9	1.2	1.9	-0.4	1.1	-1.3	1.4
Pavlov. Cond. change in total contacts	0.8	0.9	1.5	-0.1	1.0	-1.0	1.2
Pavlov. Cond. index score	0.6	0.8	1.4	-1.2	0.5	-0.8	0.9
Pavlov. Cond. latency score	0.7	0.9	1.3	-1.0	0.7	-0.9	1.1
Pavlov. Cond. lever contacts	0.2	0.3	0.4	-0.6	0.3	-0.4	0.6
Pavlov. Cond. magazine entry number	1.2	1.5	2.4	0.7	-1.2	1.3	-1.6
Pavlov. Cond. intertrial magazine entries	1.0	1.2	1.4	-1.1	-1.2	1.1	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.0	-0.9	0.6	-0.9	1.0
Pavlov. Cond. response bias	1.0	1.2	1.9	-0.7	1.0	-1.2	1.4
Pavlov. Cond. lever latency	1.7	2.4	3.0	1.4	1.7	-1.4	1.5
Pavlov. Cond. magazine entry latency	0.9	1.1	1.3	0.7	-1.2	1.1	-1.1
Pavlov. Cond. change in total contacts	0.6	1.0	1.5	-0.3	-1.1	1.1	-1.2
Pavlov. Cond. index score	1.1	1.4	2.1	-0.4	-1.4	1.3	-1.3
Pavlov. Cond. latency score	1.1	1.5	2.2	-0.4	-1.5	1.3	-1.4
Pavlov. Cond. lever contacts	1.5	2.1	2.9	-1.2	-1.7	1.4	-1.5
Pavlov. Cond. magazine entry number	0.6	0.7	0.8	-0.8	0.9	-0.8	0.9
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.7	-0.8	-0.7	0.5	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	1.7	-0.2	-1.3	1.2	-1.2
Pavlov. Cond. response bias	0.9	1.2	1.6	-0.6	-1.3	1.1	-1.2
Time in closed arm before self-admin	0.4	0.5	0.6	0.6	0.8	-0.7	0.7
Time in closed arm after self-admin	1.3	1.4	1.6	1.3	1.2	-1.2	1.0
Time in open arm before self-admin	0.9	0.9	2.1	-1.4	-0.6	0.8	-0.9
Time in open arm after self-admin	0.3	0.3	0.5	-0.5	-0.5	0.7	-0.6
Bone: periosteal estimation	3.7	7.9	13.2	-3.6	-2.3	2.7	-2.5
Bone: periosteal perimeter	1.6	2.7	10.1	-3.2	-0.4	0.7	-0.4
Bone: post-yield work	0.3	0.5	0.7	-0.5	-0.5	0.8	-0.9
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	0.3	-0.2	-0.1	0.0
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	0.3	-0.2	-0.1	0.0
Progressive ratio test 1 inactive lever presses	0.7	1.0	1.7	-0.8	-1.3	0.8	-0.9
Progressive ratio test 2 active lever presses	0.4	0.5	0.7	-0.6	-0.8	0.7	-0.6
Progressive ratio test 2 breakpoint	0.3	0.4	0.6	-0.5	-0.8	0.7	-0.5
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.0	-0.2	-0.1	0.1	0.0
Incentive Sensitization - Responses	0.6	0.8	1.1	-1.0	-1.0	0.9	-0.7
Incentive Sensitization - Breakpoint	0.5	0.7	0.9	-0.8	-0.9	0.8	-0.6
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	-0.5	0.4	-0.4	0.6
Progressive ratio	1.0	1.5	2.7	-0.6	-1.1	1.6	-1.4
Food seeking constrained by brief footshock	0.9	1.1	1.3	0.8	1.0	-1.2	1.1
Seeking ratio, punishment vs. effort	0.9	1.3	2.3	0.7	1.0	-1.5	1.2
Retroperitoneal fat weight	2.8	11.9	13.3	-3.6	-3.6	3.4	-3.2
Reaction time number correct	1.1	2.0	3.1	0.1	-1.7	1.4	-1.8
Reaction time mean minus median	0.0	0.0	0.1	0.0	0.0	-0.1	0.3
Reaction time mean minus median AUC	0.0	0.0	0.0	-0.1	-0.2	-0.0	0.1
Reaction time num false alarms	0.2	0.3	0.7	-0.9	-0.1	0.5	-0.3
Reaction time num false alarms AUC	0.1	0.2	0.3	-0.5	-0.2	0.5	-0.4
Reaction time trials correct on left	1.1	2.0	3.1	0.1	-1.7	1.4	-1.8
Reaction time trials on left	1.1	2.1	3.3	0.1	-1.7	1.5	-1.8
Reaction time mean	0.4	0.6	1.4	-1.2	-0.7	0.5	-0.3
Reaction time mean AUC	0.7	1.1	1.4	-1.2	-1.2	0.9	-0.8
Median of all reaction times	0.4	0.6	1.5	-1.2	-0.8	0.6	-0.4
Reaction time omissions	0.1	0.1	0.2	-0.1	-0.4	0.3	-0.3
Reaction time false alarm rate	0.3	0.4	0.6	-0.5	0.8	-0.4	0.7
Reaction time premature initiation rate	0.3	0.4	0.6	0.8	0.6	-0.5	0.6
Reaction time premature initiations	0.2	0.4	0.4	0.6	-0.6	0.5	-0.6
Std. dev. reaction times	0.0	0.1	0.2	-0.1	-0.4	0.3	-0.2
Reaction time trials completed	1.1	2.1	3.3	0.1	-1.7	1.5	-1.8
Reaction time trials AUC	1.0	2.0	3.0	0.1	-1.7	1.4	-1.7
Run reversals in cocaine runway, females	0.1	0.1	0.2	-0.2	-0.4	0.2	-0.3
Run reversals in cocaine runway, males	0.1	0.1	0.4	-0.6	-0.0	-0.1	0.4
Latency to leave start box in cocaine runway	1.4	1.5	2.2	-0.5	-1.5	1.4	-1.3
Latency to leave start box in cocaine runway, F	3.3	3.8	5.5	-1.0	-2.3	2.1	-2.1
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.2	0.3	-0.0	0.3
Std. dev. time between licks in bursts	1.1	1.5	2.4	0.1	-1.6	1.2	-1.5
Total sessions with >9 infusions	0.0	0.0	0.1	0.3	0.2	-0.1	0.2
Short access day 1 total inactive lever presses	0.7	0.9	1.1	-0.7	-1.0	1.0	-1.0
Short access day 10 total inactive lever presses	0.4	1.0	1.1	-1.1	-1.0	0.8	-1.0
Short access day 1 total infusions	1.0	1.3	1.8	1.3	1.2	-1.0	1.0
Short access day 10 total infusions	0.1	0.1	0.2	-0.2	-0.5	-0.0	-0.1
Short access total infusions	0.4	0.5	0.7	0.8	0.6	-0.8	0.7
Short access day 1 locomotion	1.1	1.4	1.6	1.0	1.3	-1.2	1.2
Short access day 10 total locomotion	0.9	1.7	2.1	1.0	1.3	-1.4	1.4
Short access total locomotion	1.2	1.4	1.7	0.9	1.2	-1.3	1.3
One hour access (0.3 mA shock)	0.3	0.4	0.7	-0.6	-0.9	0.5	-0.4
Compulsive drug intake	0.4	0.4	0.6	-0.7	-0.8	0.5	-0.7
One hour access (shock baseline)	0.1	0.2	0.4	-0.4	-0.6	0.4	-0.3
Social response proportion	0.2	0.3	0.9	1.0	0.2	0.2	-0.2
Social responses	0.3	0.4	0.7	0.8	0.7	-0.6	0.4
Social time	0.1	0.1	0.2	-0.4	-0.0	0.3	-0.3
Soleus weight	0.2	0.6	2.1	-1.5	-0.2	-0.5	0.3
Bone: stiffness	3.0	4.9	6.8	-2.6	-1.8	2.4	-2.0
Tibialis anterior weight	0.2	0.5	1.1	-1.0	-0.7	0.5	-0.5
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.9	1.0	-0.1	-0.4	0.0
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.1	0.0	0.1	-0.2
Time to tail flick, test, before self-admin	0.5	0.5	1.7	1.3	-0.1	-0.3	0.4
Time to tail flick, test, after self-admin	2.5	2.6	5.9	2.4	1.3	-1.4	1.1
Delta time to tail flick, vehicle, before/after SA	0.6	0.5	0.8	-0.9	-0.7	0.8	-0.6
Delta time to tail flick, test, before/after SA	0.5	0.5	1.4	0.2	1.2	-0.7	0.6
Tibia length	3.8	10.5	37.0	-6.1	-1.3	1.5	-0.9
Ambulatory time before self-admin	0.1	0.1	0.2	0.2	0.2	-0.4	0.4
Ambulatory time after self-admin	0.1	0.2	0.4	0.1	-0.6	0.3	-0.3
Bone: tissue strength	3.7	3.7	4.7	-2.2	-1.7	2.0	-1.8
Total heroin consumption	0.3	0.4	0.7	-0.9	-0.0	0.7	-0.4
Bone: trabecular number	0.1	0.2	0.4	0.0	0.4	-0.6	0.5
Bone: trabecular spacing	3.1	4.2	6.1	-0.5	-2.3	2.3	-2.5
Bone: trabecular thickness	1.6	2.0	2.7	-0.8	1.5	-1.6	1.7
Bone: trabecular tissue density	0.3	0.5	1.0	1.0	-0.3	0.7	-0.7
Water consumed over 24 hours	0.9	1.2	1.8	0.3	1.2	-1.3	1.3
Number of responses in last shaping day	0.4	0.5	0.6	0.7	0.7	-0.7	0.7