Hub : Genes

Psenen

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Psenen 0.03 0.02 2.5e-03 0.01 0.02 0.01 0.01 2.9e-02 6.6e-03 2.6e-02 4.7e-02
2 Liver gene expression Psenen 0.19 0.09 0.0e+00 0.16 0.16 0.16 0.16 6.2e-17 4.8e-17 6.3e-17 7.2e-17
3 IL gene expression Psenen 0.6 0.16 2.6e-14 0.41 0.43 0.4 0.23 7.9e-11 1.3e-11 1.1e-10 2.5e-06
4 Adipose gene expression Psenen 0.38 0.14 0.0e+00 0.25 0.28 0.28 0.28 3.4e-27 1.2e-30 3.2e-31 1.0e-30
5 PL mRNA stability Psenen 0.03 0.02 1.8e-04 0.03 0.04 0.02 0.03 2.6e-04 7.1e-05 5.8e-03 3.0e-04
6 OFC gene expression Psenen 0.83 0.1 3.8e-13 0.36 0.2 0.34 0.11 1.4e-09 1.9e-05 8.4e-09 1.6e-03
7 NAcc gene expression Psenen 0.52 0.17 0.0e+00 0.37 0.39 0.38 0.38 1.4e-59 1.8e-62 3.2e-60 1.4e-60
8 PL gene expression Psenen 0.49 0.08 0.0e+00 0.55 0.56 0.56 0.57 5.9e-72 8.6e-75 1.2e-74 3.5e-75
9 LHb mRNA stability Psenen 0.13 0.11 7.4e-03 0.04 -0 0.06 -0.01 4.0e-02 4.4e-01 1.6e-02 5.3e-01
10 Brain mRNA stability Psenen 0.02 0.02 5.9e-03 0.02 0.02 0.02 0.02 3.3e-03 5.5e-03 6.1e-03 7.8e-03
11 pVTA gene expression Psenen 0.44 0.13 0.0e+00 0.35 0.36 0.36 0.36 1.6e-29 1.3e-30 1.7e-30 2.0e-30
12 IC gene expression Psenen 0.63 0.15 0.0e+00 0.52 -0 0.52 0.02 6.0e-25 4.5e-01 6.4e-25 3.3e-02
13 Brain gene expression Psenen 0.52 0.1 0.0e+00 0.54 0.53 0.53 0.54 1.8e-59 1.1e-57 2.0e-57 4.8e-59
14 BLA gene expression Psenen 0.59 0.14 0.0e+00 0.43 0.45 0.49 0.48 1.9e-24 3.0e-26 5.0e-29 2.1e-28
15 LHb gene expression Psenen 0.66 0.18 1.7e-08 0.29 0.1 0.29 0.1 1.5e-07 2.9e-03 1.2e-07 3.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.81.42.40.9-0.9-1.2-1.01.2-1.3-1.1-1.21.31.3-1.2-1.4-1.1-1.2-1.6
Area under the delay curve0.30.30.70.8-0.7-0.4-0.80.3-0.6-0.4-0.50.40.7-0.5-0.6-0.3-0.80.1
BMI with tail0.00.10.6-0.30.30.50.1-0.60.10.40.3-0.4-0.10.10.40.40.20.8
BMI without tail0.20.61.01.0-0.9-0.7-1.00.7-0.8-0.8-0.90.70.8-0.9-0.7-0.6-1.00.3
Body weight3.314.516.73.8-3.5-3.9-3.83.9-4.1-3.7-4.04.14.1-3.9-3.8-3.8-3.7-2.8
Weight adjusted by age0.20.30.90.4-0.3-0.4-0.50.4-0.4-0.4-0.50.20.4-0.6-0.6-0.6-1.0-1.0
Bone surface1.73.13.71.8-1.8-1.7-1.81.7-1.8-1.9-1.81.31.8-1.9-1.9-1.6-1.6-1.9
Bone volume2.03.54.31.8-1.8-1.8-1.91.8-1.9-2.0-2.01.41.9-2.1-2.0-1.8-2.0-2.1
Breakpoint value in progressive ratio session0.81.01.51.2-1.1-1.0-1.20.9-1.1-1.0-1.10.91.1-0.9-1.0-1.0-0.80.8
Number of licking bursts1.93.16.7-1.81.52.31.5-2.11.81.61.7-2.6-1.91.41.71.71.20.7
Context. condit. distance diff. score0.10.10.20.2-0.40.1-0.3-0.10.2-0.2-0.3-0.5-0.2-0.40.0-0.1-0.3-0.2
Locomotion velocity, session 10.30.30.7-0.80.90.60.8-0.50.60.50.4-0.3-0.60.40.60.50.30.1
Locomotion distance, session 10.81.02.21.0-1.2-0.6-1.10.8-0.7-1.3-1.20.20.8-1.4-0.9-1.1-1.5-0.2
Locomotion velocity, session 21.01.22.1-0.90.81.01.2-0.91.20.71.1-0.9-1.21.11.31.21.21.5
Locomotion distance, session 21.21.74.5-1.00.71.61.0-1.41.40.70.9-2.0-1.40.61.51.50.72.1
Locomotion velocity, session 30.20.30.8-0.40.20.60.6-0.40.60.10.3-0.9-0.60.20.80.70.20.3
Locomotion distance, session 32.62.95.82.3-2.4-1.5-1.91.6-1.3-2.1-1.90.71.4-2.0-1.3-1.3-1.80.1
Stereotopy head waving bouts, day 30.91.02.2-1.31.50.61.3-0.70.61.31.20.1-0.71.40.80.91.10.5
Stereotopy head waving duration, day 31.82.14.0-1.82.01.11.7-1.21.01.81.7-0.3-1.01.91.11.31.70.8
Locomotion velocity, session 70.40.51.00.9-1.0-0.5-0.90.5-0.5-0.9-0.90.20.5-1.0-0.4-0.6-0.7-0.2
Locomotion distance, session 70.30.41.00.7-0.8-0.5-0.50.6-0.3-1.0-0.80.10.3-1.0-0.3-0.6-0.7-0.7
Stereotopy head waving bouts, day 71.61.83.4-1.31.11.61.1-1.61.21.21.4-1.9-1.31.21.41.41.30.7
Stereotopy head waving duration, day 72.22.73.3-1.71.71.81.5-1.81.51.71.7-1.6-1.51.71.61.61.71.4
Locomotion velocity, session 83.34.06.6-1.91.62.31.8-2.22.31.71.8-2.6-2.21.62.42.11.51.6
Locomotion distance, session 80.60.83.9-0.40.01.20.4-1.01.20.20.3-2.0-1.1-0.01.10.90.20.8
Degree of sensitization distance0.40.41.2-1.00.90.50.7-0.40.50.60.6-0.1-0.50.60.40.20.6-1.1
Degree of sensitization stereotypy1.11.23.6-0.90.71.40.7-1.41.00.91.1-1.9-1.00.91.11.11.00.5
Conditioned locomotion0.70.82.5-0.80.80.90.7-1.00.80.90.9-0.8-0.80.90.80.80.61.6
Cocaine response after cond. corrected0.20.20.6-0.60.80.00.7-0.10.40.70.40.7-0.20.70.40.20.40.1
Cocaine response after cond. not corrected0.20.20.6-0.50.7-0.10.70.10.30.50.40.8-0.20.70.30.20.4-0.5
Cocaine response before conditioning1.41.75.01.2-1.4-1.2-1.21.4-1.3-1.6-1.10.61.3-1.1-1.2-1.0-0.9-2.2
Saline control response0.10.20.5-0.50.50.20.5-0.30.50.40.40.1-0.40.50.40.30.70.2
Bone: connectivity density0.20.40.60.7-0.7-0.6-0.50.7-0.7-0.7-0.50.60.7-0.6-0.8-0.3-0.4-0.6
Bone: cortical apparent density1.11.52.2-1.31.21.41.2-1.31.41.11.0-1.5-1.40.81.31.30.91.1
Bone: cortical area1.52.33.11.5-1.4-1.7-1.41.8-1.3-1.6-1.61.71.3-1.6-1.3-1.6-1.4-1.5
Bone: cortical porosity1.01.12.4-0.70.51.30.6-1.30.90.91.2-1.5-0.91.11.01.11.31.0
Bone: cortical porosity1.51.73.4-0.90.71.60.9-1.61.21.11.4-1.8-1.21.31.31.31.51.1
Bone: cortical thickness0.50.91.60.9-0.7-1.1-0.71.2-0.8-1.0-1.01.30.8-1.0-0.8-0.9-0.9-0.9
Bone: cortical thickness0.50.61.0-0.91.00.70.9-0.70.90.80.7-0.5-0.80.70.80.80.71.0
Bone: cortical tissue density1.31.82.7-1.41.31.51.3-1.51.51.21.1-1.6-1.50.91.41.40.91.2
Condit. Reinf. active minus inactive responses0.20.30.6-0.50.60.50.5-0.50.40.60.5-0.5-0.30.50.40.70.50.8
Condit. Reinf. active-inactive response ratio0.40.51.0-0.71.00.30.8-0.40.20.90.80.2-0.21.00.30.70.70.8
Condit. Reinf. active responses2.22.73.9-1.51.51.81.4-1.81.61.61.5-1.8-1.61.41.71.81.52.0
Condit. Reinf. inactive responses2.12.64.8-1.31.11.91.2-1.91.81.31.3-2.2-1.81.01.81.71.41.9
Incentive salience index mean0.30.31.1-0.40.50.60.4-0.60.50.50.5-0.6-0.40.50.50.70.51.1
Condit. Reinf. lever presses0.10.10.90.0-0.00.20.1-0.30.30.20.2-0.3-0.20.20.30.40.21.0
Condit. Reinf. active minus inactive responses0.60.81.41.2-1.1-1.2-0.81.1-0.8-1.1-0.81.10.8-0.7-0.7-0.7-0.50.4
Condit. Reinf. active-inactive response ratio0.10.20.4-0.30.30.20.5-0.20.60.30.3-0.2-0.50.30.60.50.40.6
Condit. Reinf. active responses2.43.34.82.2-2.2-2.0-1.82.0-1.8-2.1-1.81.71.8-1.7-1.7-1.7-1.5-0.7
Condit. Reinf. inactive responses3.34.36.92.5-2.6-2.1-2.32.1-2.2-2.3-1.91.52.1-1.8-2.0-2.0-1.8-1.2
Condit. Reinf. lever presses6.18.410.23.1-3.0-3.2-2.93.2-3.1-3.0-2.82.93.1-2.6-3.0-2.9-2.5-2.0
Condit. Reinf. lever reinforcers received2.83.96.02.4-2.4-2.1-2.12.1-1.9-2.3-2.01.61.9-1.9-1.8-1.9-1.7-1.0
Conditioned reinforcement - actives0.50.81.3-1.10.91.00.9-0.90.70.71.0-1.1-0.80.90.80.81.2-0.1
Conditioned reinforcement - inactives0.10.21.30.6-0.70.1-0.5-0.2-0.1-0.2-0.1-0.60.1-0.10.10.1-0.01.2
Conditioned locomotion2.43.13.6-1.81.71.91.7-1.91.81.71.8-1.8-1.81.71.81.81.91.4
Patch foraging indifference point 0 sec0.00.00.10.3-0.3-0.2-0.10.2-0.1-0.10.10.10.30.2-0.10.20.00.2
Patch foraging indifference point AUC0.71.01.6-1.01.01.01.1-1.01.11.11.0-0.6-1.11.01.11.30.90.9
Delay disc. indifference point, 0s delay0.50.51.30.7-0.8-0.1-1.1-0.0-0.6-0.6-0.9-0.20.6-1.1-0.8-0.6-1.1-0.0
Delay disc. indifference point, 16s delay0.30.41.01.0-0.8-0.6-0.80.4-0.7-0.4-0.50.40.7-0.4-0.4-0.2-0.60.2
Delay disc. indifference point, 2s delay1.21.32.01.3-1.3-0.9-1.40.9-1.0-1.2-1.40.71.1-1.4-1.3-1.0-1.4-0.6
Delay disc. indifference point, 24s delay1.51.72.81.7-1.5-1.4-1.51.3-1.3-1.2-1.31.41.3-1.2-1.1-1.1-1.4-0.0
Delay disc. indifference point, 4s delay0.00.00.30.1-0.20.3-0.1-0.30.10.10.2-0.5-0.00.20.00.20.20.1
Delay disc. indifference point, 8s delay0.10.20.50.5-0.5-0.3-0.50.4-0.4-0.3-0.30.30.4-0.3-0.4-0.2-0.7-0.5
Indifference point function ln k0.20.40.70.7-0.6-0.6-0.60.6-0.7-0.8-0.70.20.6-0.7-0.6-0.6-0.50.2
Indifference point function log k0.20.40.70.7-0.6-0.6-0.60.6-0.7-0.8-0.70.20.6-0.7-0.6-0.6-0.50.2
Patch foraging total patch changes 0 sec0.00.10.20.4-0.5-0.3-0.20.3-0.2-0.3-0.10.20.40.1-0.20.0-0.10.0
Patch foraging total patch changes 12 sec0.20.20.7-0.30.40.20.5-0.20.30.50.60.3-0.10.90.40.50.50.4
Patch foraging total patch changes 18 sec0.00.10.3-0.1-0.10.40.1-0.30.40.10.3-0.5-0.40.20.20.3-0.2-0.2
Patch foraging total patch changes 24 sec0.71.22.71.1-1.2-0.8-1.20.8-0.8-1.0-1.10.61.0-1.2-1.0-1.0-1.4-1.7
Patch foraging total patch changes 6 sec0.10.10.3-0.00.0-0.00.40.00.30.20.40.3-0.20.60.40.50.30.1
Patch foraging time to switch 0 sec0.61.11.9-1.21.30.91.2-0.90.91.31.3-0.3-1.01.41.01.01.20.5
Patch foraging water rate 0 sec0.50.91.7-0.80.70.90.9-0.91.20.70.9-1.1-1.10.81.11.01.01.3
Patch foraging water rate 12 sec0.81.74.61.2-1.5-0.8-1.41.0-1.2-1.6-1.0-0.11.2-1.3-1.2-1.3-1.3-2.1
Patch foraging water rate 18 sec0.10.10.3-0.30.20.40.3-0.30.20.10.4-0.6-0.10.40.40.40.50.1
Patch foraging water rate 24 sec0.20.31.90.5-0.80.3-0.6-0.2-0.2-0.6-0.3-1.40.1-0.70.00.1-0.40.3
Patch foraging water rate 6 sec1.31.83.31.6-1.8-1.0-1.61.1-1.3-1.7-1.30.21.3-1.5-1.3-1.2-1.4-1.2
Seeking ratio, delayed vs. immediate footshock1.72.13.21.6-1.7-1.0-1.81.0-1.4-1.4-1.60.41.4-1.7-1.3-1.4-1.7-1.6
Distance traveled before self-admin0.00.00.10.1-0.3-0.0-0.20.0-0.1-0.3-0.2-0.10.1-0.1-0.1-0.10.20.3
Distance traveled after self-admin1.82.33.11.6-1.7-1.6-1.51.7-1.4-1.8-1.61.41.4-1.4-1.4-1.4-1.3-1.3
Extensor digitorum longus weight0.10.51.9-0.91.40.30.9-0.40.61.00.20.7-0.50.30.60.80.10.7
Bone: elastic displacement0.00.00.1-0.10.1-0.10.10.2-0.1-0.10.10.20.10.2-0.10.00.4-0.4
Bone: elastic work1.82.43.01.5-1.4-1.6-1.51.6-1.7-1.5-1.51.71.7-1.4-1.7-1.7-1.2-1.5
Bone: endosteal estimation1.43.13.61.8-1.8-1.9-1.81.9-1.7-1.9-1.71.61.7-1.6-1.7-1.9-1.5-1.8
Bone: endosteal perimeter1.12.33.21.7-1.8-1.6-1.61.6-1.3-1.8-1.51.11.3-1.5-1.3-1.6-1.3-1.4
Epididymis fat weight0.10.21.00.2-0.2-0.2-0.40.3-0.5-0.4-0.50.10.5-0.7-0.5-0.4-1.0-0.6
Delta time in closed arm before/after self-admin1.41.31.51.1-1.0-1.2-1.11.1-1.2-1.0-1.21.21.2-1.1-1.1-1.1-1.2-1.0
Delta time in open arm before/after self-admin0.40.40.9-0.70.60.60.7-0.50.60.60.9-0.6-0.60.90.50.50.80.5
Diff in mean of infusions in LGA sessions1.01.25.2-0.70.80.90.8-1.11.01.11.0-0.8-1.01.11.01.01.12.3
Delay discount exponential model param0.40.40.8-0.90.80.60.8-0.50.70.50.6-0.6-0.80.50.60.30.80.0
Extinction: sum of active levers before priming3.84.26.21.8-1.5-2.3-1.92.2-2.2-1.8-2.12.52.1-2.0-2.3-2.3-2.1-1.6
Active lever presses in extinction session 61.01.04.30.6-0.4-1.5-0.51.4-1.0-0.9-0.82.11.0-0.5-1.1-1.1-0.1-0.6
Bone: final force1.82.93.41.8-1.6-1.8-1.71.8-1.7-1.5-1.81.81.7-1.7-1.6-1.9-1.7-1.2
Bone: final moment2.43.94.62.0-1.8-2.1-1.92.1-1.9-1.9-2.12.11.9-2.0-1.9-2.1-2.0-1.5
Food consumed during 24 hour testing period0.60.81.71.2-1.3-0.7-1.10.7-0.8-1.1-0.80.10.8-0.9-1.0-0.7-0.9-0.5
Glucose0.20.30.7-0.80.70.40.7-0.30.30.30.5-0.3-0.40.50.40.50.5-0.3
Heart weight0.00.10.20.4-0.4-0.1-0.30.1-0.1-0.3-0.1-0.30.2-0.1-0.1-0.10.00.3
Delay discount hyperbolic model param0.30.30.6-0.80.70.40.8-0.40.60.40.5-0.4-0.70.50.60.30.7-0.1
Intermittent access intake day 1-15 change1.73.54.41.8-1.6-1.8-1.91.8-2.1-1.7-2.01.72.0-2.0-2.0-2.0-1.9-1.8
Intermittent access intake escalation1.53.03.81.5-1.4-1.7-1.71.6-1.9-1.5-1.81.51.9-1.9-1.8-1.8-1.7-1.9
Intermittent access intake escalation 21.31.41.91.1-1.0-1.4-1.01.3-1.3-1.1-1.21.41.3-1.1-1.2-1.2-0.9-1.4
Intermitt. access day 1 inactive lever presses0.93.66.62.6-2.4-2.1-2.12.0-1.7-1.9-1.91.81.7-1.7-1.7-1.7-1.9-0.2
Intermitt. access day 15 inactive lever presses0.40.82.01.4-1.4-0.8-1.20.7-0.7-0.8-0.90.40.8-0.8-0.6-0.6-0.90.6
Intermitt. access escalation Index0.10.21.4-0.1-0.10.5-0.0-0.50.2-0.10.1-1.2-0.3-0.10.20.20.20.1
Intermittent access day 1 total infusions1.32.07.6-1.30.82.00.9-1.81.40.91.3-2.8-1.40.91.31.31.10.7
Intermittent access day 15 total infusions0.20.21.00.1-0.40.3-0.5-0.2-0.4-0.4-0.4-1.00.4-0.7-0.3-0.3-0.4-0.8
Intermittent access terminal intake (last 3 days)0.20.32.6-0.2-0.10.8-0.0-0.70.20.00.2-1.6-0.2-0.00.30.30.3-0.0
Intermittent access total infusions0.40.53.5-0.50.11.10.1-0.90.40.20.4-1.9-0.40.10.50.50.3-0.1
Intermittent access day 1 locomotion1.01.35.1-0.60.21.50.5-1.51.20.60.9-2.2-1.20.71.11.10.91.4
Intermittent access day 15 total locomotion0.10.21.10.3-0.60.3-0.5-0.3-0.0-0.4-0.2-1.1-0.0-0.4-0.1-0.1-0.10.4
Intermittent access total locomotion1.01.33.7-0.90.61.50.7-1.41.20.81.0-1.9-1.10.81.11.11.01.2
Intermittent access standard deviation2.24.65.72.3-2.4-2.0-2.42.0-2.2-2.2-2.31.52.3-2.2-2.2-2.2-2.3-1.6
Left kidney weight2.712.615.83.3-3.1-3.5-3.43.6-3.7-3.4-3.63.63.7-3.6-3.5-3.6-3.7-4.0
Right kidney weight3.214.417.13.4-3.1-3.8-3.53.9-4.1-3.6-3.84.04.0-3.8-3.9-3.9-3.8-4.1
Cocaine induced anxiety0.00.00.4-0.00.2-0.10.00.0-0.10.2-0.00.70.10.00.00.00.00.2
Post-drug Anxiety0.20.31.1-0.20.50.20.4-0.40.40.80.40.3-0.40.50.60.60.41.0
Baseline Anxiety0.10.10.20.3-0.30.1-0.1-0.20.20.10.1-0.5-0.20.10.30.30.10.4
Tail length5.019.421.64.5-4.3-4.6-4.34.6-4.4-4.6-4.74.34.3-4.4-4.5-4.4-4.4-3.5
Length with tail6.930.133.55.6-5.4-5.8-5.45.8-5.8-5.7-5.65.55.7-5.3-5.6-5.5-5.2-4.5
Length without tail3.411.012.63.3-3.2-3.5-3.23.5-3.5-3.4-3.53.53.5-3.3-3.3-3.3-3.0-2.7
Times rat made contact with spout0.20.31.0-0.90.80.50.6-0.40.20.40.3-0.5-0.20.20.10.2-0.2-1.0
Lifetime Intake0.50.63.6-0.70.31.20.4-1.00.60.30.6-1.9-0.60.30.60.60.5-0.2
Liver weight, left0.40.71.0-1.00.90.90.9-0.80.80.80.9-1.0-0.80.81.00.80.60.2
Liver weight, right0.50.81.6-0.91.00.71.1-0.70.90.80.9-0.5-0.91.01.01.01.01.2
Locomotor activity0.60.92.1-1.31.30.71.3-0.60.70.91.3-0.3-0.71.50.60.61.20.5
Locomotor testing distance0.50.91.8-1.41.20.91.1-0.80.80.91.2-0.8-0.81.20.60.51.2-0.1
Locomotor testing rearing1.02.13.6-1.81.51.71.5-1.51.61.31.5-1.9-1.61.31.21.01.40.1
Locomotion in novel chamber0.81.04.0-0.81.00.51.0-0.60.81.00.9-0.2-0.81.11.01.01.12.0
Locomotion in novel chamber post-restriction0.20.31.1-0.40.40.30.5-0.40.40.60.50.0-0.40.80.50.50.71.0
Fecal boli incidents, locomotor time 13.75.410.8-2.22.31.92.4-2.12.22.32.3-1.5-2.22.62.32.32.63.3
Change in fecal boli incidents, locomotor task0.10.10.9-0.30.5-0.30.50.30.00.40.21.0-0.10.50.20.20.3-0.2
Time >=10cm from walls, locomotor time 10.10.10.2-0.20.30.10.3-0.10.30.30.2-0.1-0.40.30.20.2-0.00.3
Bouts of movement, locomotor time 10.60.71.61.1-1.3-0.5-1.10.5-0.6-1.1-0.9-0.10.7-1.0-0.8-0.8-1.0-0.1
Total resting periods, locomotor time 10.40.41.00.9-1.0-0.4-0.90.3-0.4-0.9-0.7-0.10.6-0.8-0.6-0.6-0.60.1
Rest time, locomotor task time 12.83.58.5-1.71.81.51.7-1.81.62.01.8-0.9-1.52.11.91.92.22.9
Distance moved, locomotor task time 10.30.42.00.4-0.6-0.2-0.50.4-0.3-0.7-0.7-0.20.2-0.8-0.5-0.5-0.9-1.4
Vertical activity count, locomotor time 11.22.83.81.8-2.0-1.6-1.71.7-1.5-1.9-1.71.11.4-1.7-1.6-1.6-1.7-1.9
Time >=10cm from walls, locomotor time 21.72.54.4-1.41.41.51.5-1.51.71.51.5-1.3-1.71.61.61.61.52.1
Bouts of movement, locomotor time 20.00.10.40.0-0.30.1-0.10.0-0.0-0.4-0.1-0.70.0-0.2-0.1-0.10.0-0.4
Total resting periods, locomotor time 20.00.10.5-0.2-0.00.30.2-0.20.3-0.20.2-0.7-0.20.20.10.10.50.1
Rest time, locomotor task time 20.91.23.6-0.91.00.81.0-0.90.81.01.2-0.5-0.71.41.01.01.61.9
Distance moved, locomotor task time 20.20.21.60.1-0.30.2-0.3-0.0-0.1-0.3-0.4-0.50.1-0.6-0.1-0.1-0.7-1.3
Vertical activity count, locomotor time 20.91.31.91.3-1.3-0.9-1.21.0-1.0-1.2-1.20.71.0-1.3-0.9-0.9-1.2-1.4
Light reinforcement 10.10.10.5-0.1-0.00.40.2-0.30.40.00.3-0.7-0.30.20.30.50.40.3
Light reinforcement 22.43.77.6-1.81.91.82.0-1.91.91.91.8-1.4-1.81.81.92.11.82.7
Bone: marrow area1.43.23.71.8-1.8-1.9-1.81.9-1.8-1.9-1.71.71.7-1.6-1.7-1.9-1.4-1.9
Bone: maximum diameter1.32.43.01.6-1.5-1.7-1.61.7-1.5-1.6-1.61.71.4-1.5-1.4-1.6-1.5-1.5
Bone: maximum force3.05.46.02.4-2.2-2.4-2.42.4-2.4-2.2-2.42.32.4-2.3-2.3-2.5-2.3-2.0
Bone: maximum moment3.66.37.02.6-2.4-2.6-2.52.6-2.5-2.4-2.62.52.5-2.6-2.4-2.6-2.5-2.2
Mean time between licks in bursts0.00.10.40.4-0.40.0-0.2-0.00.1-0.1-0.0-0.3-0.1-0.1-0.00.00.00.7
Mean num. licks in bursts1.11.83.61.0-0.8-1.6-0.91.6-1.5-1.1-1.31.91.5-1.2-1.4-1.4-1.2-1.1
Cd content in liver0.10.10.2-0.40.40.30.1-0.30.10.40.2-0.2-0.10.20.20.10.2-0.4
Co content in liver0.60.71.1-0.91.00.61.0-0.70.81.00.9-0.0-0.81.00.90.90.90.9
Cu content in liver1.41.62.21.2-1.1-1.2-1.31.2-1.3-1.1-1.31.31.3-1.3-1.4-1.4-1.5-1.0
Fe content in liver0.50.61.1-0.80.80.70.8-0.70.60.90.8-0.5-0.61.00.60.70.81.0
K content in liver0.10.10.20.1-0.0-0.20.10.10.00.10.20.3-0.00.40.10.10.40.4
Mg content in liver1.11.12.0-0.91.20.61.2-0.60.91.11.2-0.0-0.91.41.01.01.41.4
Mn content in liver1.21.32.5-1.21.30.71.4-0.71.01.21.3-0.1-1.01.61.21.01.60.9
Na content in liver0.70.81.60.9-1.1-0.9-0.90.9-0.8-1.0-0.80.70.8-0.7-0.8-0.9-0.7-1.3
Rb content in liver0.20.20.7-0.20.40.30.2-0.50.30.80.4-0.0-0.30.40.30.30.30.8
Se content in liver6.47.69.7-2.93.12.43.1-2.42.82.92.8-1.6-2.82.92.82.82.82.9
Sr content in liver0.50.41.1-0.70.70.40.7-0.40.50.60.8-0.2-0.51.00.50.61.00.2
Zn content in liver2.52.84.0-1.72.01.41.8-1.51.52.01.8-0.5-1.51.91.51.61.71.9
Bone: minimum diameter2.85.27.32.6-2.7-2.3-2.52.3-2.1-2.5-2.31.82.0-2.3-2.0-2.3-2.0-2.0
Time in familiar zone, hab. session 10.50.52.10.4-0.1-1.0-0.30.9-0.5-0.5-0.81.40.5-0.8-0.4-0.7-0.6-0.6
Time in novel zone, hab. session 11.51.53.7-1.00.71.50.8-1.51.01.11.4-1.9-1.01.41.01.41.21.1
Total zone transitions, hab. session 10.10.10.40.1-0.30.2-0.2-0.20.1-0.3-0.3-0.7-0.1-0.40.30.2-0.10.1
Total locomotion distance, hab. session 10.60.91.61.1-1.3-0.9-1.10.9-1.2-1.2-0.70.31.1-0.6-1.1-1.0-0.3-0.7
Locomotion velocity, hab. session 10.40.51.00.7-0.9-0.7-0.80.7-0.9-1.0-0.40.30.9-0.3-0.8-0.8-0.1-0.6
Time in familiar zone, hab. session 21.01.03.61.0-0.7-1.5-0.71.3-1.1-0.6-0.61.91.1-0.2-1.2-1.0-0.4-0.4
Time in novel zone, hab. session 20.70.71.9-0.90.71.20.7-1.00.90.60.6-1.4-0.80.30.90.90.40.3
Total zone transitions, hab. session 23.03.86.4-1.91.62.31.7-2.12.01.61.9-2.5-2.01.72.12.11.52.0
Total locomotion distance, hab. session 20.20.31.4-0.30.10.70.1-0.70.20.20.7-1.2-0.20.70.40.40.60.5
Locomotion velocity, hab. session 20.30.41.3-0.50.20.80.3-0.70.40.40.7-1.2-0.40.80.50.50.70.6
Novel to familiar place preference ratio0.10.20.40.5-0.5-0.3-0.40.3-0.5-0.3-0.40.20.4-0.3-0.40.1-0.3-0.7
Novelty place preference0.10.10.70.4-0.5-0.2-0.40.3-0.3-0.3-0.30.00.3-0.3-0.30.1-0.2-0.9
Time in novel zone, NPP test0.10.10.50.2-0.3-0.0-0.20.0-0.1-0.2-0.2-0.20.1-0.2-0.10.3-0.1-0.7
Total zone transitions, NPP test0.10.10.3-0.10.00.30.2-0.20.3-0.3-0.2-0.5-0.2-0.30.40.3-0.20.5
Total locomotion distance, NPP test2.23.04.31.7-1.8-1.7-1.71.8-1.9-2.1-1.71.31.9-1.6-1.8-1.7-1.5-1.6
Locomotion velocity, NPP test2.23.04.11.7-1.8-1.8-1.71.9-2.0-2.0-1.61.42.0-1.5-1.9-1.7-1.4-1.6
Intraocular pressure0.10.10.3-0.10.10.20.2-0.30.50.30.1-0.6-0.50.10.40.20.00.2
Delta distance traveled before/after self-admin2.62.73.61.7-1.7-1.7-1.51.8-1.5-1.7-1.71.61.6-1.6-1.5-1.5-1.9-1.7
Delta ambulatory time before/after self-admin2.43.03.51.8-1.8-1.7-1.71.8-1.7-1.8-1.71.51.7-1.7-1.7-1.7-1.9-1.7
Parametrial fat weight0.30.71.9-0.91.4-0.01.2-0.10.51.00.71.2-0.61.00.50.50.90.4
Pavlov. Cond. lever latency0.20.30.90.3-0.1-0.5-0.40.4-0.6-0.1-0.60.90.5-0.5-0.6-0.6-0.5-0.7
Pavlov. Cond. magazine entry latency0.81.13.6-1.10.71.21.0-0.90.80.41.3-1.9-0.81.20.70.91.10.1
Pavlov. Cond. change in total contacts0.60.72.9-0.50.11.00.5-0.80.80.20.8-1.7-0.80.60.91.00.70.7
Pavlov. Cond. index score0.70.92.7-0.90.51.10.9-0.90.80.41.1-1.6-0.81.10.91.00.90.4
Pavlov. Cond. latency score0.40.52.0-0.60.30.90.6-0.70.70.20.9-1.4-0.70.80.70.70.60.5
Pavlov. Cond. lever contacts0.10.10.50.0-0.30.20.2-0.10.4-0.20.3-0.7-0.30.30.30.30.20.4
Pavlov. Cond. magazine entry number0.60.73.40.9-0.5-1.1-0.70.8-0.7-0.3-1.01.80.7-0.9-0.5-0.8-0.70.0
Pavlov. Cond. intertrial magazine entries1.01.12.4-0.91.10.91.1-1.01.31.00.8-0.4-1.30.71.41.11.01.6
Pavlov. Cond. lever-magazine prob. diff.1.01.23.5-1.10.71.31.1-1.11.00.61.3-1.9-1.01.21.01.21.00.5
Pavlov. Cond. response bias0.50.61.8-0.80.50.80.9-0.60.60.21.0-1.4-0.61.00.60.80.8-0.0
Pavlov. Cond. lever latency4.86.57.9-2.82.82.62.7-2.62.82.72.5-2.2-2.82.52.72.42.31.9
Pavlov. Cond. magazine entry latency2.83.44.82.0-2.0-2.0-1.91.9-2.1-1.9-1.61.62.1-1.5-2.2-1.8-1.3-1.3
Pavlov. Cond. change in total contacts7.211.613.43.6-3.7-3.4-3.73.3-3.5-3.4-3.32.73.6-3.3-3.6-3.4-3.1-3.3
Pavlov. Cond. index score5.57.59.32.9-2.9-2.8-2.92.8-3.0-2.9-2.62.33.0-2.5-3.1-2.6-2.4-2.4
Pavlov. Cond. latency score4.76.27.82.7-2.7-2.5-2.62.5-2.7-2.6-2.32.12.8-2.2-2.8-2.4-2.0-2.0
Pavlov. Cond. lever contacts5.37.38.62.9-2.9-2.7-2.92.7-2.9-2.8-2.72.32.9-2.7-2.9-2.6-2.6-2.1
Pavlov. Cond. magazine entry number4.65.67.6-2.42.42.32.4-2.42.62.52.3-1.9-2.72.32.72.42.02.3
Pavlov. Cond. intertrial magazine entries0.91.32.2-1.21.21.11.2-1.21.41.31.0-0.8-1.51.01.51.30.60.6
Pavlov. Cond. lever-magazine prob. diff.5.37.18.92.8-2.8-2.7-2.82.7-2.9-2.8-2.52.23.0-2.4-3.0-2.5-2.3-2.5
Pavlov. Cond. response bias6.69.010.43.2-3.2-2.9-3.23.0-3.2-3.2-3.02.33.2-3.0-3.2-2.9-2.9-2.4
Time in closed arm before self-admin1.11.43.5-1.20.91.61.0-1.51.21.11.1-1.9-1.30.81.21.20.60.3
Time in closed arm after self-admin0.10.10.30.3-0.30.1-0.3-0.2-0.10.1-0.3-0.20.1-0.30.10.1-0.50.6
Time in open arm before self-admin3.53.85.82.0-1.8-2.4-1.72.4-1.9-2.0-1.92.41.9-1.5-2.0-2.0-1.4-1.7
Time in open arm after self-admin0.91.01.70.8-0.9-1.2-0.71.3-1.0-1.1-0.71.21.0-0.6-1.1-1.1-0.4-1.2
Bone: periosteal estimation2.14.55.52.1-2.1-2.3-2.12.3-2.0-2.3-2.22.12.0-2.1-2.0-2.2-1.9-2.2
Bone: periosteal perimeter1.01.72.41.3-1.3-1.5-1.21.5-1.1-1.5-1.31.41.1-1.2-1.1-1.4-1.0-1.3
Bone: post-yield work2.13.14.52.1-2.1-1.6-2.01.6-1.7-1.9-1.81.21.7-1.9-1.8-1.7-1.7-1.3
Progressive ratio test 1 active lever presses0.10.20.90.2-0.60.3-0.5-0.1-0.2-0.5-0.2-0.90.2-0.4-0.2-0.2-0.2-0.4
Progressive ratio test 1 breakpoint0.20.20.80.3-0.70.2-0.5-0.1-0.3-0.6-0.3-0.90.3-0.5-0.2-0.2-0.2-0.4
Progressive ratio test 1 inactive lever presses0.30.41.30.8-1.10.1-0.8-0.2-0.2-0.6-0.4-1.10.1-0.6-0.1-0.1-0.41.1
Progressive ratio test 2 active lever presses0.10.21.2-0.50.20.60.1-0.50.20.00.1-1.1-0.2-0.20.10.10.1-0.5
Progressive ratio test 2 breakpoint0.20.21.5-0.60.30.80.2-0.60.30.10.2-1.2-0.3-0.10.20.20.2-0.5
Progressive ratio test 2 inactive lever presses0.30.41.60.9-0.9-0.1-0.8-0.0-0.3-0.5-0.7-0.50.2-0.8-0.3-0.3-0.71.3
Incentive Sensitization - Responses0.20.31.1-0.80.60.80.5-0.80.60.50.3-1.1-0.70.10.40.40.30.1
Incentive Sensitization - Breakpoint0.20.31.1-0.70.60.80.4-0.70.60.50.3-1.0-0.60.10.40.40.20.1
Sum of active levers in priming session hrs 5-60.10.10.2-0.30.30.20.2-0.20.20.30.1-0.0-0.40.10.20.20.30.5
Progressive ratio0.10.20.6-0.20.10.30.3-0.30.30.10.6-0.4-0.30.70.40.40.80.7
Food seeking constrained by brief footshock1.62.02.81.6-1.7-1.6-1.51.6-1.5-1.6-1.31.51.5-1.0-1.4-1.4-0.7-0.8
Seeking ratio, punishment vs. effort0.40.60.90.9-0.9-0.7-0.80.7-0.7-0.8-0.90.60.7-0.9-0.8-0.8-0.9-0.7
Retroperitoneal fat weight0.62.66.0-2.22.50.92.3-0.81.51.61.70.3-1.32.01.41.41.90.5
Reaction time number correct0.00.00.0-0.0-0.0-0.1-0.00.1-0.0-0.1-0.10.10.0-0.2-0.2-0.1-0.10.0
Reaction time mean minus median0.30.71.30.8-0.7-0.9-0.70.9-0.9-0.7-0.80.90.7-0.8-0.5-0.7-0.9-1.1
Reaction time mean minus median AUC0.71.73.41.2-1.1-1.3-1.11.4-1.4-1.1-1.31.51.2-1.2-1.1-1.2-1.3-1.8
Reaction time num false alarms0.50.71.2-1.00.91.00.7-1.00.91.10.9-1.0-0.80.80.70.70.5-0.1
Reaction time num false alarms AUC0.71.21.8-1.21.11.21.0-1.31.11.31.2-1.2-1.01.20.91.00.8-0.0
Reaction time trials correct on left0.00.00.0-0.0-0.0-0.1-0.00.1-0.0-0.1-0.10.10.0-0.2-0.2-0.1-0.10.0
Reaction time trials on left0.00.00.1-0.0-0.0-0.1-0.00.1-0.0-0.1-0.10.10.0-0.2-0.2-0.1-0.1-0.0
Reaction time mean0.30.61.20.6-0.7-0.5-0.80.7-0.8-0.8-0.80.10.6-0.9-0.6-0.8-0.9-1.1
Reaction time mean AUC0.20.41.10.5-0.5-0.4-0.60.6-0.7-0.6-0.60.10.5-0.7-0.5-0.6-0.6-1.0
Median of all reaction times0.10.10.30.2-0.3-0.1-0.40.2-0.4-0.5-0.3-0.40.2-0.5-0.2-0.4-0.4-0.6
Reaction time omissions0.00.00.3-0.20.2-0.10.10.2-0.20.00.00.10.10.1-0.1-0.1-0.1-0.6
Reaction time false alarm rate0.50.71.1-0.90.81.00.7-1.00.81.00.9-1.0-0.70.90.80.80.6-0.2
Reaction time premature initiation rate0.10.10.20.2-0.30.2-0.3-0.2-0.2-0.10.3-0.40.30.40.1-0.10.40.3
Reaction time premature initiations0.00.10.20.2-0.30.2-0.2-0.2-0.1-0.10.3-0.30.20.30.0-0.10.40.5
Std. dev. reaction times0.91.63.71.1-1.2-1.0-1.31.1-1.3-1.2-1.30.71.2-1.4-1.0-1.2-1.5-1.9
Reaction time trials completed0.00.00.1-0.0-0.0-0.1-0.00.1-0.0-0.1-0.10.10.0-0.2-0.2-0.1-0.1-0.0
Reaction time trials AUC0.00.00.0-0.20.2-0.00.20.00.10.0-0.00.2-0.1-0.0-0.1-0.0-0.0-0.0
Run reversals in cocaine runway, females1.31.32.01.2-1.2-0.9-1.31.0-1.1-1.1-1.20.71.1-1.4-1.2-1.2-1.4-1.1
Run reversals in cocaine runway, males0.40.41.0-0.71.0-0.10.90.20.10.70.70.7-0.11.00.30.30.8-0.1
Latency to leave start box in cocaine runway0.60.71.30.8-0.9-0.5-1.10.4-0.8-0.7-1.00.50.8-1.1-1.0-1.0-1.0-0.5
Latency to leave start box in cocaine runway, F0.20.20.50.5-0.5-0.1-0.60.1-0.3-0.3-0.5-0.10.3-0.7-0.4-0.4-0.60.3
Latency to leave start box in cocaine runway, M0.30.30.80.3-0.4-0.2-0.60.2-0.5-0.4-0.50.20.5-0.6-0.7-0.7-0.5-0.9
Std. dev. time between licks in bursts0.20.21.00.6-0.70.0-0.3-0.10.3-0.20.3-0.6-0.20.40.30.00.81.0
Total sessions with >9 infusions0.81.02.0-1.31.01.21.0-1.01.00.71.0-1.4-1.00.80.80.91.0-0.3
Short access day 1 total inactive lever presses0.70.92.21.3-1.5-0.3-1.40.2-0.7-1.0-1.0-0.40.6-1.3-0.7-0.7-1.10.6
Short access day 10 total inactive lever presses1.12.64.92.2-2.1-1.5-1.91.3-1.3-1.5-1.81.11.3-1.8-1.5-1.5-1.80.9
Short access day 1 total infusions0.00.10.4-0.0-0.10.30.1-0.20.4-0.10.1-0.6-0.4-0.10.10.10.1-0.0
Short access day 10 total infusions0.30.31.4-0.70.40.80.4-0.60.40.20.4-1.2-0.40.30.40.40.3-0.7
Short access total infusions0.60.72.2-1.00.71.10.8-0.90.90.50.8-1.5-0.90.60.70.70.8-0.3
Short access day 1 locomotion0.60.81.2-0.90.81.00.9-1.01.00.80.9-1.1-1.00.70.90.90.70.5
Short access day 10 total locomotion0.10.21.00.7-1.0-0.2-0.60.2-0.3-0.7-0.2-0.40.3-0.1-0.2-0.20.00.3
Short access total locomotion1.31.52.8-1.10.81.41.1-1.31.30.91.3-1.7-1.31.21.21.31.30.9
One hour access (0.3 mA shock)0.80.92.01.0-1.4-0.3-1.20.5-0.9-1.3-0.9-0.70.9-1.1-0.8-0.8-0.7-0.9
Compulsive drug intake0.10.10.40.3-0.50.1-0.2-0.20.1-0.20.0-0.7-0.1-0.00.10.10.20.6
One hour access (shock baseline)0.10.20.70.1-0.40.2-0.5-0.1-0.4-0.4-0.2-0.80.4-0.5-0.3-0.3-0.2-0.8
Social response proportion1.11.32.81.4-1.1-1.4-1.11.2-1.1-0.8-1.21.71.2-1.0-0.8-0.8-1.10.3
Social responses0.30.32.00.7-0.4-0.8-0.20.5-0.2-0.1-0.21.20.30.1-0.10.00.21.4
Social time2.33.24.42.1-2.1-1.8-2.01.8-1.8-1.9-2.01.41.8-2.0-1.6-1.5-1.8-0.9
Soleus weight0.00.10.3-0.40.60.20.4-0.20.30.50.20.3-0.30.30.40.40.20.5
Bone: stiffness1.52.53.31.7-1.5-1.6-1.61.5-1.7-1.4-1.71.61.6-1.7-1.6-1.6-1.8-1.1
Tibialis anterior weight0.10.21.0-0.60.9-0.10.50.10.20.4-0.21.0-0.2-0.10.20.2-0.1-0.0
Time to tail flick, vehicle, before self-admin0.20.20.9-0.40.30.60.3-0.50.30.20.4-0.9-0.40.30.40.40.3-0.2
Time to tail flick, vehicle, after self-admin0.00.10.30.2-0.2-0.3-0.00.2-0.0-0.10.10.30.20.30.00.10.50.3
Time to tail flick, test, before self-admin0.50.51.60.4-0.70.2-0.9-0.1-0.5-0.5-0.8-0.90.6-1.2-0.5-0.5-1.3-1.0
Time to tail flick, test, after self-admin0.20.20.7-0.40.40.40.5-0.40.50.30.4-0.5-0.40.40.50.50.50.8
Delta time to tail flick, vehicle, before/after SA0.30.30.60.7-0.7-0.8-0.60.7-0.5-0.6-0.40.80.7-0.2-0.5-0.5-0.1-0.2
Delta time to tail flick, test, before/after SA1.71.73.9-1.11.30.51.6-0.61.31.11.40.2-1.31.81.21.22.01.7
Tibia length3.18.510.12.8-2.7-2.8-3.02.9-3.1-3.0-3.12.33.2-3.1-3.0-3.0-2.9-2.6
Ambulatory time before self-admin0.00.10.60.3-0.3-0.1-0.20.1-0.0-0.2-0.20.1-0.0-0.0-0.00.00.20.8
Ambulatory time after self-admin3.64.35.42.3-2.3-2.2-2.22.2-2.1-2.3-2.21.92.1-2.0-2.0-2.0-2.0-1.1
Bone: tissue strength3.33.34.52.1-2.1-1.7-2.11.7-1.8-1.7-1.91.41.8-1.9-1.7-1.8-1.9-1.4
Total heroin consumption0.40.51.00.8-0.8-0.4-1.00.4-0.9-0.7-0.70.10.8-0.8-0.7-0.8-0.80.4
Bone: trabecular number1.62.63.31.6-1.5-1.5-1.61.6-1.7-1.5-1.61.41.8-1.7-1.8-1.5-1.7-1.5
Bone: trabecular spacing0.10.20.40.3-0.3-0.6-0.20.5-0.5-0.30.00.70.50.3-0.4-0.60.2-0.5
Bone: trabecular thickness0.10.10.60.0-0.00.1-0.20.0-0.1-0.1-0.4-0.10.1-0.7-0.2-0.1-0.8-0.6
Bone: trabecular tissue density1.42.14.5-2.12.11.31.9-1.21.41.61.4-0.7-1.41.51.41.21.4-0.1
Water consumed over 24 hours0.60.71.10.7-0.7-0.8-0.70.9-0.9-0.9-0.90.70.9-0.9-1.0-0.8-1.1-0.8
Number of responses in last shaping day0.30.30.90.3-0.6-0.1-0.50.3-0.4-0.8-0.4-0.50.4-0.6-0.5-0.5-0.4-1.0