Prtn3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Prtn3	0.05	0.04	1.4e-03	0.03	0.02	0.02	0.02	1.7e-03	4.6e-03	6.2e-03	6.5e-03
2	PL	gene expression	Prtn3	0.09	0.07	2.8e-05	0.03	0.04	0.03	0.04	3.4e-04	9.2e-05	2.1e-04	6.7e-05
3	BLA	gene expression	Prtn3	0.05	0.04	1.4e-03	0.03	0.04	0.04	0.04	1.4e-02	2.3e-03	4.0e-03	4.6e-03
4	IC	gene expression	Prtn3	0.28	0.15	8.0e-06	0.07	0.13	0.13	0.13	4.8e-04	4.5e-06	4.5e-06	4.0e-06
5	NAcc	gene expression	Prtn3	0.08	0.06	2.2e-05	0.02	0.03	0.03	0.03	4.5e-04	7.2e-06	6.9e-06	1.6e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.2	2.2	4.3	-0.8	1.6	-0.3	1.9	-2.1
Area under the delay curve	1.3	2.1	2.9	1.7	-1.5	-1.7	-1.1	1.2
BMI with tail	4.8	16.7	24.2	4.7	-4.1	-4.9	-3.2	3.3
BMI without tail	1.2	6.4	7.6	2.8	-2.7	-2.6	-2.3	2.3
Body weight	0.7	2.9	4.4	2.0	-1.7	-2.1	-1.3	1.3
Weight adjusted by age	0.4	1.3	1.6	1.1	-1.3	-0.8	-1.2	1.2
Bone surface	3.0	5.8	9.2	-1.8	2.8	0.5	3.0	-3.0
Bone volume	2.6	5.2	8.4	-1.6	2.6	0.3	2.9	-2.9
Breakpoint value in progressive ratio session	1.3	2.4	4.7	-1.9	1.4	2.2	0.7	-1.1
Number of licking bursts	0.2	0.7	1.6	0.5	-0.9	-0.3	-1.3	0.9
Context. condit. distance diff. score	0.4	0.4	1.0	0.3	-0.7	-0.4	-0.6	1.0
Locomotion velocity, session 1	1.6	1.8	2.7	-1.0	1.5	0.8	1.6	-1.6
Locomotion distance, session 1	2.9	3.7	6.6	-1.6	2.1	0.8	2.6	-2.0
Locomotion velocity, session 2	7.4	8.8	10.7	-3.2	3.2	2.6	3.3	-2.5
Locomotion distance, session 2	5.7	7.9	11.6	-2.3	3.1	1.7	3.4	-3.2
Locomotion velocity, session 3	3.7	4.3	8.7	-2.5	1.9	2.9	1.2	-1.1
Locomotion distance, session 3	0.1	0.1	0.5	0.1	-0.3	0.1	-0.4	0.7
Stereotopy head waving bouts, day 3	5.7	6.8	9.4	-3.1	2.6	2.8	2.3	-2.2
Stereotopy head waving duration, day 3	5.6	6.9	9.6	-3.1	2.6	3.0	2.1	-2.2
Locomotion velocity, session 7	0.4	0.4	1.1	-1.0	0.0	0.9	-0.2	0.6
Locomotion distance, session 7	1.1	1.4	2.3	0.6	-1.3	-0.5	-1.5	1.5
Stereotopy head waving bouts, day 7	1.0	1.1	2.4	-0.8	1.2	0.2	1.1	-1.5
Stereotopy head waving duration, day 7	1.9	2.4	4.4	-1.2	1.7	0.7	1.6	-2.1
Locomotion velocity, session 8	2.1	2.5	5.2	-1.4	1.6	1.2	2.3	-1.3
Locomotion distance, session 8	0.7	1.1	1.6	-1.2	1.1	0.8	1.2	-0.8
Degree of sensitization distance	0.3	0.4	0.5	0.4	-0.7	-0.7	-0.4	0.7
Degree of sensitization stereotypy	0.4	0.5	1.7	0.7	-0.2	-1.3	-0.0	-0.4
Conditioned locomotion	3.3	3.9	5.6	2.0	-2.0	-1.3	-2.0	2.4
Cocaine response after cond. corrected	7.0	10.4	11.9	3.4	-3.4	-2.8	-3.3	3.1
Cocaine response after cond. not corrected	7.2	10.4	12.1	3.3	-3.5	-2.9	-3.4	3.0
Cocaine response before conditioning	1.0	1.2	2.0	-1.3	1.0	0.9	0.6	-1.4
Saline control response	0.4	0.5	0.8	0.8	-0.7	-0.5	-0.9	0.7
Bone: connectivity density	0.5	0.9	1.8	-0.4	0.8	-0.5	1.2	-1.3
Bone: cortical apparent density	0.6	0.9	1.8	1.2	-0.8	-1.3	-0.6	0.4
Bone: cortical area	0.1	0.2	0.5	-0.1	0.2	-0.7	0.4	-0.2
Bone: cortical porosity	0.5	0.5	1.0	-0.6	0.8	0.3	1.0	-0.7
Bone: cortical porosity	0.8	0.8	1.8	-0.7	1.0	0.1	1.4	-1.0
Bone: cortical thickness	0.3	0.5	1.8	0.5	-0.3	-1.4	-0.1	0.2
Bone: cortical thickness	0.4	0.5	1.5	0.4	-0.8	-0.1	-1.2	0.6
Bone: cortical tissue density	0.4	0.6	1.3	1.0	-0.7	-1.1	-0.5	0.2
Condit. Reinf. active minus inactive responses	3.0	3.4	6.2	-2.2	1.8	2.5	1.4	-1.0
Condit. Reinf. active-inactive response ratio	0.7	0.7	2.2	-1.1	0.6	1.5	0.1	-0.1
Condit. Reinf. active responses	4.1	5.3	6.3	-2.5	2.4	2.5	2.4	-1.6
Condit. Reinf. inactive responses	2.2	2.9	5.3	-1.6	1.9	1.2	2.3	-1.3
Incentive salience index mean	2.9	3.7	5.1	-2.3	2.0	2.1	1.9	-1.3
Condit. Reinf. lever presses	1.6	2.3	4.7	-1.2	1.7	0.4	2.2	-1.6
Condit. Reinf. active minus inactive responses	0.5	0.8	2.0	-1.1	0.5	1.4	-0.2	-0.6
Condit. Reinf. active-inactive response ratio	0.2	0.4	1.0	0.6	-0.6	-0.2	-1.0	0.4
Condit. Reinf. active responses	0.8	1.1	2.4	-1.4	0.8	1.5	0.2	-0.7
Condit. Reinf. inactive responses	0.5	0.7	1.6	-1.2	0.6	1.3	0.2	-0.3
Condit. Reinf. lever presses	0.6	0.8	2.1	-1.2	0.7	1.5	-0.1	-0.2
Condit. Reinf. lever reinforcers received	0.4	0.6	1.5	-1.0	0.4	1.2	-0.4	-0.3
Conditioned reinforcement - actives	0.1	0.5	1.2	-1.0	0.1	1.1	-0.2	-0.5
Conditioned reinforcement - inactives	0.1	0.1	0.4	-0.1	-0.5	-0.2	-0.6	0.1
Conditioned locomotion	4.4	6.6	9.5	-3.1	2.5	3.1	1.9	-2.0
Patch foraging indifference point 0 sec	0.0	0.1	0.3	0.3	-0.2	-0.6	0.0	0.1
Patch foraging indifference point AUC	0.2	0.6	0.9	-0.7	0.8	1.0	0.5	-0.7
Delay disc. indifference point, 0s delay	2.2	2.5	8.1	1.9	-0.8	-2.8	0.3	0.1
Delay disc. indifference point, 16s delay	0.1	0.2	0.4	0.6	-0.4	-0.4	-0.3	0.2
Delay disc. indifference point, 2s delay	2.8	3.2	6.9	2.1	-1.5	-2.6	-0.9	1.2
Delay disc. indifference point, 24s delay	0.7	1.2	1.7	1.3	-1.2	-1.0	-1.0	0.8
Delay disc. indifference point, 4s delay	0.6	0.6	1.2	1.0	-0.7	-1.1	-0.4	0.5
Delay disc. indifference point, 8s delay	1.4	2.3	3.0	1.6	-1.7	-1.3	-1.5	1.5
Indifference point function ln k	0.2	0.5	0.8	0.6	-0.8	-0.5	-0.9	0.6
Indifference point function log k	0.2	0.5	0.8	0.6	-0.8	-0.5	-0.9	0.6
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	0.2	-0.2	-0.5	-0.0	0.2
Patch foraging total patch changes 12 sec	0.4	0.6	0.7	0.6	-0.8	-0.8	-0.8	0.8
Patch foraging total patch changes 18 sec	0.4	1.0	1.2	-1.1	1.1	1.1	0.9	-0.9
Patch foraging total patch changes 24 sec	0.1	0.2	0.4	-0.5	0.5	0.2	0.4	-0.7
Patch foraging total patch changes 6 sec	0.3	0.5	0.7	-0.6	0.8	0.4	0.9	-0.7
Patch foraging time to switch 0 sec	0.2	0.6	1.6	-0.2	0.6	-0.9	1.3	-0.4
Patch foraging water rate 0 sec	0.6	2.3	4.3	1.1	-1.7	-0.2	-2.1	1.7
Patch foraging water rate 12 sec	1.2	5.0	7.1	2.3	-2.6	-1.5	-2.7	1.9
Patch foraging water rate 18 sec	1.9	4.3	9.6	1.2	-2.3	-0.1	-3.1	2.3
Patch foraging water rate 24 sec	4.3	6.1	10.0	2.2	-2.8	-1.0	-3.2	2.6
Patch foraging water rate 6 sec	0.9	1.3	3.5	0.8	-1.2	0.3	-1.9	1.0
Seeking ratio, delayed vs. immediate footshock	2.4	3.4	5.2	-2.1	1.9	2.3	1.4	-1.4
Distance traveled before self-admin	0.1	0.1	0.3	0.5	-0.2	-0.5	0.0	0.4
Distance traveled after self-admin	0.0	0.0	0.0	0.0	0.1	0.0	0.1	0.2
Extensor digitorum longus weight	4.4	17.5	19.6	4.4	-4.4	-4.2	-3.8	4.0
Bone: elastic displacement	0.1	0.2	0.5	0.0	0.4	0.2	0.3	-0.7
Bone: elastic work	0.3	0.3	0.7	0.8	-0.4	-0.8	-0.3	0.2
Bone: endosteal estimation	0.1	0.1	0.2	0.4	-0.3	-0.4	-0.1	0.4
Bone: endosteal perimeter	0.4	1.1	1.3	-1.1	1.1	0.9	1.0	-1.0
Epididymis fat weight	0.1	0.6	1.7	0.0	-0.8	-0.0	-1.3	0.7
Delta time in closed arm before/after self-admin	4.2	3.9	6.5	1.8	-2.2	-1.0	-2.6	2.0
Delta time in open arm before/after self-admin	0.4	0.4	0.6	0.8	-0.6	-0.8	-0.3	0.6
Diff in mean of infusions in LGA sessions	0.9	1.6	2.5	-1.5	1.2	1.6	0.9	-0.9
Delay discount exponential model param	1.4	1.9	2.5	-1.6	1.4	1.5	1.2	-1.2
Extinction: sum of active levers before priming	0.2	0.4	0.9	-0.8	0.4	1.0	-0.1	-0.3
Active lever presses in extinction session 6	2.0	2.0	2.2	-1.5	1.5	1.4	1.3	-1.4
Bone: final force	0.5	0.8	2.0	0.9	-0.6	-1.4	-0.2	0.8
Bone: final moment	0.4	0.7	1.7	0.9	-0.6	-1.3	-0.2	0.8
Food consumed during 24 hour testing period	0.7	1.4	2.2	1.1	-1.2	-1.0	-1.0	1.5
Glucose	2.5	3.9	5.5	2.3	-2.1	-2.3	-1.6	1.4
Heart weight	0.2	0.3	0.8	-0.5	-0.1	0.8	-0.9	0.0
Delay discount hyperbolic model param	2.1	2.7	3.9	-1.9	1.6	2.0	1.2	-1.3
Intermittent access intake day 1-15 change	0.5	2.7	6.7	-1.9	1.3	2.6	0.6	-0.9
Intermittent access intake escalation	0.4	2.2	5.9	-1.8	1.2	2.4	0.5	-0.7
Intermittent access intake escalation 2	1.3	2.2	5.1	-1.8	1.3	2.3	0.6	-0.7
Intermitt. access day 1 inactive lever presses	0.1	0.8	1.8	0.3	-1.1	0.2	-1.4	1.0
Intermitt. access day 15 inactive lever presses	0.1	0.5	0.9	-0.9	0.6	0.8	0.6	-0.5
Intermitt. access escalation Index	0.1	0.4	0.8	0.8	0.1	-0.9	0.6	-0.1
Intermittent access day 1 total infusions	0.1	0.2	0.4	-0.3	-0.4	0.3	-0.6	-0.0
Intermittent access day 15 total infusions	0.6	1.6	3.6	-1.7	0.9	1.9	0.3	-0.7
Intermittent access terminal intake (last 3 days)	0.7	1.3	2.6	-1.6	0.8	1.6	0.4	-0.8
Intermittent access total infusions	0.4	0.5	1.1	-1.0	0.3	1.0	0.1	-0.6
Intermittent access day 1 locomotion	0.3	0.6	1.7	-1.1	0.1	1.3	-0.4	-0.3
Intermittent access day 15 total locomotion	0.6	2.2	5.6	-1.8	1.1	2.4	0.6	-0.8
Intermittent access total locomotion	0.9	1.1	2.9	-1.3	0.6	1.7	0.2	-0.4
Intermittent access standard deviation	1.0	5.1	8.1	-2.9	1.9	2.8	1.4	-1.9
Left kidney weight	0.1	1.1	2.1	0.5	-1.2	-0.0	-1.4	1.5
Right kidney weight	0.1	0.7	1.7	-0.5	-0.3	1.3	-0.8	0.8
Cocaine induced anxiety	1.3	3.6	4.6	-1.9	2.1	1.4	2.1	-1.9
Post-drug Anxiety	3.2	3.6	4.8	-1.9	2.2	1.4	2.1	-1.9
Baseline Anxiety	0.0	0.0	0.1	0.0	-0.1	0.2	-0.3	0.2
Tail length	1.2	6.3	13.9	-3.0	2.2	3.7	1.4	-1.4
Length with tail	1.0	4.6	9.3	-2.6	1.9	3.0	1.3	-1.3
Length without tail	0.0	0.0	0.1	0.1	-0.2	-0.1	-0.3	0.3
Times rat made contact with spout	1.3	1.5	2.7	1.1	-1.4	-0.5	-1.2	1.7
Lifetime Intake	0.3	0.3	0.7	-0.8	0.2	0.7	-0.0	-0.6
Liver weight, left	0.8	1.4	1.8	1.4	-1.2	-1.3	-1.0	0.8
Liver weight, right	1.2	2.1	2.6	1.4	-1.6	-1.1	-1.5	1.5
Locomotor activity	3.7	5.8	7.3	-2.6	2.7	2.3	2.3	-2.3
Locomotor testing distance	1.6	3.9	5.2	-2.1	2.3	1.8	1.8	-1.9
Locomotor testing rearing	0.1	0.2	0.7	0.3	-0.4	0.0	-0.8	0.5
Locomotion in novel chamber	0.3	0.4	0.9	-0.6	0.5	0.9	0.2	-0.4
Locomotion in novel chamber post-restriction	0.2	0.7	2.0	-1.1	0.6	1.4	-0.0	-0.1
Fecal boli incidents, locomotor time 1	0.5	1.4	1.9	1.2	-1.1	-1.4	-0.9	1.2
Change in fecal boli incidents, locomotor task	0.2	0.2	0.2	-0.5	0.4	0.4	0.5	-0.2
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.6	0.5	0.2	-0.8	0.8	-0.1
Bouts of movement, locomotor time 1	0.1	0.2	0.6	-0.4	0.0	0.8	0.0	0.2
Total resting periods, locomotor time 1	0.2	0.2	0.7	-0.6	0.2	0.8	0.2	0.2
Rest time, locomotor task time 1	0.3	0.5	0.8	-0.9	0.6	0.9	0.7	0.4
Distance moved, locomotor task time 1	0.2	0.5	1.2	0.7	0.1	-1.1	0.6	-0.7
Vertical activity count, locomotor time 1	0.1	1.0	1.7	1.3	-1.0	-1.0	-1.0	0.5
Time >=10cm from walls, locomotor time 2	0.8	2.3	2.5	1.5	-1.6	-1.5	-1.4	1.6
Bouts of movement, locomotor time 2	0.4	1.3	2.7	-1.1	1.2	0.8	1.6	-0.9
Total resting periods, locomotor time 2	0.3	1.4	2.9	-1.1	1.2	0.7	1.7	-0.9
Rest time, locomotor task time 2	0.6	1.1	1.4	-1.2	1.1	1.0	1.2	-0.8
Distance moved, locomotor task time 2	0.4	0.6	0.8	0.9	-0.8	-0.9	-0.8	0.4
Vertical activity count, locomotor time 2	0.6	1.5	2.3	1.1	-1.4	-0.9	-1.5	1.2
Light reinforcement 1	2.6	11.7	14.2	-3.8	3.7	3.5	2.9	-3.1
Light reinforcement 2	1.5	3.5	4.4	-2.1	2.1	1.7	1.6	-1.8
Bone: marrow area	0.1	0.1	0.2	0.4	-0.3	-0.4	-0.1	0.4
Bone: maximum diameter	1.5	3.0	4.1	-2.0	1.9	1.4	1.6	-1.7
Bone: maximum force	0.6	1.1	2.2	1.1	-0.9	-1.5	-0.6	1.0
Bone: maximum moment	0.5	1.0	1.9	1.1	-0.8	-1.4	-0.5	1.0
Mean time between licks in bursts	0.6	3.8	6.5	-2.2	1.9	2.6	1.3	-1.6
Mean num. licks in bursts	0.0	0.1	0.2	0.4	-0.2	-0.1	0.2	0.3
Cd content in liver	0.2	0.2	0.4	-0.1	0.5	0.3	0.5	-0.6
Co content in liver	0.8	0.9	1.6	-0.9	1.0	1.3	0.4	-1.0
Cu content in liver	0.9	1.1	1.9	-0.9	1.2	0.6	1.4	-0.9
Fe content in liver	0.2	0.2	0.6	-0.7	0.2	0.6	-0.0	0.2
K content in liver	0.8	0.8	1.2	-0.9	1.0	0.3	1.1	-0.8
Mg content in liver	0.6	0.6	0.8	-0.6	0.9	0.5	0.9	-0.9
Mn content in liver	3.6	4.0	5.9	-2.1	2.2	1.5	2.4	-1.7
Na content in liver	0.3	0.3	0.7	-0.2	0.4	-0.7	0.8	-0.4
Rb content in liver	0.9	1.0	1.7	-0.8	1.1	0.2	1.3	-1.2
Se content in liver	0.3	0.3	0.7	-0.8	0.5	0.8	0.3	-0.1
Sr content in liver	0.2	0.2	0.3	0.3	-0.4	-0.1	-0.5	0.5
Zn content in liver	0.7	0.8	3.0	-0.6	0.3	1.7	-0.4	-0.3
Bone: minimum diameter	0.1	0.1	0.2	-0.4	0.4	0.1	0.4	-0.3
Time in familiar zone, hab. session 1	0.7	0.7	2.1	-1.1	0.5	1.5	0.0	-0.1
Time in novel zone, hab. session 1	0.3	0.4	1.1	0.7	-0.1	-1.0	0.4	-0.4
Total zone transitions, hab. session 1	3.2	4.5	6.0	-1.8	2.4	1.3	2.4	-2.4
Total locomotion distance, hab. session 1	4.7	6.7	8.7	-2.6	2.9	1.6	3.0	-2.6
Locomotion velocity, hab. session 1	5.0	7.1	9.1	-2.7	3.0	1.9	3.0	-2.5
Time in familiar zone, hab. session 2	2.4	2.7	6.7	-2.2	1.2	2.6	0.4	-0.4
Time in novel zone, hab. session 2	2.3	2.6	5.7	2.4	-1.3	-2.3	-0.3	0.4
Total zone transitions, hab. session 2	2.2	2.8	6.2	-0.4	1.6	-0.1	2.5	-2.2
Total locomotion distance, hab. session 2	3.6	4.7	6.8	-1.7	2.4	1.5	2.6	-2.5
Locomotion velocity, hab. session 2	4.3	5.8	9.3	-1.8	2.6	1.5	3.0	-2.7
Novel to familiar place preference ratio	1.2	1.6	4.6	1.7	-0.8	-2.1	0.2	0.2
Novelty place preference	0.7	0.9	2.7	1.2	-0.5	-1.6	0.4	-0.0
Time in novel zone, NPP test	0.9	1.1	3.1	1.4	-0.7	-1.7	0.1	0.2
Total zone transitions, NPP test	1.6	2.4	4.4	-0.9	1.7	0.2	2.0	-2.1
Total locomotion distance, NPP test	1.2	1.7	3.4	-1.0	1.5	0.3	1.8	-1.3
Locomotion velocity, NPP test	1.5	2.2	4.1	-1.2	1.7	0.5	2.0	-1.5
Intraocular pressure	1.0	1.6	3.0	1.3	-1.3	-0.4	-1.7	1.1
Delta distance traveled before/after self-admin	0.2	0.2	0.5	-0.7	0.4	0.7	0.0	-0.2
Delta ambulatory time before/after self-admin	0.2	0.4	0.7	-0.8	0.6	0.8	0.3	-0.5
Parametrial fat weight	0.1	0.2	0.5	0.1	0.4	0.0	0.7	-0.5
Pavlov. Cond. lever latency	0.9	1.1	2.3	1.0	-1.2	-0.5	-1.5	0.8
Pavlov. Cond. magazine entry latency	2.5	3.2	5.9	-2.3	1.6	2.4	1.3	-0.8
Pavlov. Cond. change in total contacts	0.3	0.3	0.7	-0.8	0.4	0.6	0.4	0.1
Pavlov. Cond. index score	1.0	1.3	2.1	-1.4	1.1	1.2	1.2	-0.5
Pavlov. Cond. latency score	1.5	1.9	2.6	-1.6	1.4	1.2	1.5	-0.9
Pavlov. Cond. lever contacts	0.7	0.9	1.8	-0.9	1.0	0.4	1.3	-0.7
Pavlov. Cond. magazine entry number	0.7	0.9	1.9	1.3	-0.7	-1.4	-0.6	-0.0
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.6	0.2	-0.3	0.2	-0.8	0.4
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	2.2	-1.5	1.1	1.3	1.2	-0.5
Pavlov. Cond. response bias	0.8	1.0	2.0	-1.4	0.8	1.4	0.7	-0.1
Pavlov. Cond. lever latency	0.2	0.3	0.6	0.6	-0.4	-0.8	0.0	-0.3
Pavlov. Cond. magazine entry latency	0.2	0.3	0.6	-0.8	0.3	0.7	0.2	-0.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.4	-0.5	0.2	0.6	-0.2	-0.0
Pavlov. Cond. index score	0.1	0.2	0.6	-0.6	0.2	0.7	-0.1	0.2
Pavlov. Cond. latency score	0.2	0.3	0.6	-0.7	0.4	0.8	0.1	0.0
Pavlov. Cond. lever contacts	0.2	0.2	0.4	-0.5	0.1	0.6	-0.4	0.6
Pavlov. Cond. magazine entry number	0.4	0.5	1.1	1.0	-0.6	-1.0	-0.3	0.3
Pavlov. Cond. intertrial magazine entries	0.5	1.0	1.4	1.0	-1.2	-0.7	-1.2	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.7	-0.8	0.4	0.8	0.1	-0.0
Pavlov. Cond. response bias	0.4	0.5	1.5	-0.8	0.4	1.2	-0.2	0.3
Time in closed arm before self-admin	0.1	0.2	0.6	-0.1	0.4	-0.5	0.8	-0.2
Time in closed arm after self-admin	0.1	0.2	0.4	-0.1	-0.2	0.4	-0.6	0.5
Time in open arm before self-admin	0.2	0.2	0.5	-0.4	0.5	0.3	0.4	-0.7
Time in open arm after self-admin	0.7	0.8	1.3	1.1	-0.9	-1.1	-0.4	0.5
Bone: periosteal estimation	0.0	0.1	0.2	-0.1	0.3	-0.5	0.5	-0.2
Bone: periosteal perimeter	0.4	0.7	1.1	-0.9	1.0	0.5	1.0	-0.8
Bone: post-yield work	0.5	0.9	1.1	0.9	-1.1	-0.8	-0.9	1.1
Progressive ratio test 1 active lever presses	0.2	0.4	1.0	-0.1	-0.8	0.2	-1.0	0.2
Progressive ratio test 1 breakpoint	0.2	0.4	1.1	-0.1	-0.8	0.2	-1.0	0.2
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.4	-0.6	-0.1	0.6	-0.2	-0.1
Progressive ratio test 2 active lever presses	0.3	0.4	1.1	-0.1	-0.8	0.3	-1.0	0.3
Progressive ratio test 2 breakpoint	0.3	0.4	1.0	-0.2	-0.8	0.4	-1.0	0.3
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.6	-0.8	0.2	0.4	0.2	-0.5
Incentive Sensitization - Responses	0.2	0.7	1.2	0.6	-1.1	-0.3	-1.0	0.9
Incentive Sensitization - Breakpoint	0.2	0.5	0.8	0.5	-0.9	-0.1	-0.8	0.8
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.3	0.1
Progressive ratio	0.1	0.2	0.3	0.5	-0.6	-0.4	-0.4	0.5
Food seeking constrained by brief footshock	0.7	0.9	1.3	-1.1	0.9	0.9	1.0	-0.8
Seeking ratio, punishment vs. effort	0.4	0.8	1.0	-1.0	1.0	0.8	0.9	-0.8
Retroperitoneal fat weight	0.6	2.7	3.5	1.7	-1.9	-1.3	-1.7	1.6
Reaction time number correct	1.1	3.9	5.3	1.9	-2.2	-0.9	-2.2	2.3
Reaction time mean minus median	0.0	0.3	0.6	-0.7	0.3	0.8	-0.0	-0.4
Reaction time mean minus median AUC	0.0	0.2	0.5	-0.4	0.5	0.1	0.7	-0.3
Reaction time num false alarms	1.0	1.6	2.5	1.0	-1.5	-0.6	-1.6	1.5
Reaction time num false alarms AUC	0.8	1.9	3.0	1.1	-1.6	-0.6	-1.7	1.6
Reaction time trials correct on left	1.1	3.9	5.3	1.9	-2.2	-0.9	-2.2	2.3
Reaction time trials on left	1.1	3.8	5.2	1.9	-2.2	-0.9	-2.1	2.3
Reaction time mean	0.0	0.1	0.1	0.1	0.2	-0.3	0.4	-0.4
Reaction time mean AUC	0.0	0.1	0.2	0.2	0.1	-0.3	0.4	-0.4
Median of all reaction times	0.1	0.2	0.4	0.4	-0.0	-0.7	0.3	-0.3
Reaction time omissions	0.3	0.5	1.3	-0.3	0.8	0.3	1.1	-0.7
Reaction time false alarm rate	0.1	0.1	0.2	0.1	-0.3	-0.3	-0.4	0.2
Reaction time premature initiation rate	0.2	0.3	0.9	-0.7	0.4	1.0	0.0	-0.4
Reaction time premature initiations	0.2	0.6	1.3	0.3	-0.8	0.6	-1.1	0.9
Std. dev. reaction times	0.0	0.1	0.2	-0.4	0.3	0.3	0.2	-0.4
Reaction time trials completed	1.1	3.8	5.2	1.9	-2.2	-0.9	-2.1	2.3
Reaction time trials AUC	1.3	4.4	6.1	2.0	-2.4	-0.9	-2.3	2.5
Run reversals in cocaine runway, females	0.8	0.9	1.0	-1.0	1.0	0.9	0.9	-0.8
Run reversals in cocaine runway, males	1.8	2.0	2.6	-1.6	1.6	1.5	1.2	-1.1
Latency to leave start box in cocaine runway	1.1	1.6	2.5	-0.9	1.4	0.5	1.5	-1.6
Latency to leave start box in cocaine runway, F	1.0	1.3	2.6	-0.4	1.2	-0.3	1.6	-1.5
Latency to leave start box in cocaine runway, M	0.7	0.7	1.7	-1.0	0.6	1.3	0.1	-0.5
Std. dev. time between licks in bursts	0.4	0.8	0.9	-0.9	0.9	0.9	1.0	-0.7
Total sessions with >9 infusions	0.1	0.2	0.3	-0.5	-0.3	0.5	-0.5	-0.0
Short access day 1 total inactive lever presses	0.1	0.3	0.5	-0.7	0.3	0.7	0.3	-0.5
Short access day 10 total inactive lever presses	0.1	0.4	0.7	0.5	-0.7	-0.1	-0.7	0.8
Short access day 1 total infusions	0.2	0.5	0.9	-0.9	0.5	0.7	0.3	-0.7
Short access day 10 total infusions	0.1	0.2	0.5	-0.3	-0.5	0.3	-0.7	-0.1
Short access total infusions	0.2	0.2	0.5	-0.7	0.1	0.6	-0.1	-0.5
Short access day 1 locomotion	0.6	1.0	2.1	-1.4	0.7	1.3	0.2	-0.7
Short access day 10 total locomotion	0.7	2.7	7.3	-2.2	0.9	2.7	0.1	-0.9
Short access total locomotion	0.8	1.2	2.6	-1.6	0.6	1.6	0.0	-0.7
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.1	-0.4	-0.1	-0.4	-0.0
Compulsive drug intake	0.3	0.4	1.1	0.7	0.3	-1.1	0.7	0.1
One hour access (shock baseline)	0.1	0.3	0.6	-0.7	-0.3	0.8	-0.6	-0.3
Social response proportion	1.4	1.8	2.8	-1.1	1.4	1.1	1.7	-1.4
Social responses	6.6	8.6	10.8	-3.3	3.0	3.1	2.6	-2.6
Social time	0.2	0.3	0.6	0.8	-0.4	-0.8	-0.2	-0.3
Soleus weight	6.2	18.4	27.2	4.9	-4.3	-5.2	-3.4	3.3
Bone: stiffness	0.9	1.7	3.6	1.0	-1.1	-1.9	-0.8	1.3
Tibialis anterior weight	0.9	3.2	3.7	1.8	-1.8	-1.8	-1.5	1.9
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.4	0.5	0.3	0.3	-0.2
Time to tail flick, vehicle, after self-admin	0.2	0.4	1.2	-0.1	-0.4	0.6	-1.1	0.3
Time to tail flick, test, before self-admin	0.8	0.9	1.5	-0.9	1.1	0.6	1.0	-1.2
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.4	0.3	0.4	0.1	-0.0
Delta time to tail flick, vehicle, before/after SA	1.1	1.2	2.3	0.8	-1.3	-0.4	-1.5	1.0
Delta time to tail flick, test, before/after SA	0.6	0.7	1.3	0.5	-0.9	0.0	-1.1	1.1
Tibia length	0.4	1.2	2.3	-1.3	1.0	1.5	0.6	-0.9
Ambulatory time before self-admin	0.1	0.2	0.3	0.5	-0.3	-0.5	-0.0	0.4
Ambulatory time after self-admin	0.0	0.0	0.0	-0.0	0.1	-0.0	0.2	0.1
Bone: tissue strength	1.0	1.0	2.2	1.3	-0.8	-1.5	-0.3	0.8
Total heroin consumption	1.6	1.9	2.3	-1.5	1.5	1.4	1.1	-1.3
Bone: trabecular number	1.5	2.8	5.1	-1.6	1.7	0.9	1.6	-2.3
Bone: trabecular spacing	2.9	4.2	6.5	1.8	-2.2	-0.9	-2.5	2.4
Bone: trabecular thickness	2.3	3.2	7.3	-0.9	1.9	-0.2	2.7	-2.1
Bone: trabecular tissue density	1.1	2.0	2.8	1.7	-1.5	-1.4	-1.0	1.4
Water consumed over 24 hours	0.3	0.5	0.9	0.7	-0.6	-0.9	-0.4	0.8
Number of responses in last shaping day	0.5	0.7	1.8	-1.1	0.4	1.3	-0.2	0.1