Prss50

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Prss50 0.17 0.14 2.2e-07 0.14 0.11 0.15 0.14 5.2e-08 1.3e-06 2.4e-08 5.1e-08
2 NAcc gene expression Prss50 0.17 0.11 0.0e+00 0.15 0.17 0.17 0.17 2.0e-17 2.7e-19 1.0e-19 1.3e-19
3 BLA mRNA stability Prss50 0.15 0.13 2.5e-06 0.06 0.09 0.08 0.08 2.5e-04 1.0e-05 4.4e-05 6.1e-05
4 PL mRNA stability Prss50 0.04 0.04 3.9e-05 0.03 0.04 0.01 0.03 5.5e-04 5.2e-05 8.2e-03 1.8e-04
5 OFC gene expression Prss50 0.2 0.15 1.5e-03 0.07 0.09 0.08 0.07 9.9e-03 3.3e-03 6.0e-03 9.9e-03
6 PL gene expression Prss50 0.44 0.25 0.0e+00 0.19 0.19 0.19 0.19 1.0e-20 1.6e-20 1.2e-20 1.7e-20
7 Brain mRNA stability Prss50 0.04 0.04 1.6e-04 0.04 0.04 0.04 0.03 1.7e-04 2.0e-04 2.8e-04 5.0e-04
8 Brain gene expression Prss50 0.09 0.07 1.2e-08 0.09 0.09 0.08 0.09 1.3e-08 2.7e-08 6.4e-08 1.2e-08
9 IL gene expression Prss50 0.28 0.2 1.3e-04 0.12 0.11 0.06 0.1 7.6e-04 1.1e-03 1.8e-02 2.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.00.00.1-0.2-0.20.20.20.2-0.2-0.30.2-0.1
Area under the delay curve2.02.22.41.51.5-1.6-1.5-1.51.51.5-1.41.3
BMI with tail0.41.22.8-1.0-1.11.11.11.1-1.7-1.10.7-1.0
BMI without tail1.73.44.7-1.9-1.72.01.91.9-2.2-1.81.8-1.4
Body weight6.627.831.9-5.4-5.35.45.45.4-5.6-5.35.0-4.6
Weight adjusted by age0.20.20.3-0.3-0.20.50.50.5-0.6-0.40.50.1
Bone surface0.10.10.30.40.4-0.3-0.3-0.30.10.3-0.30.6
Bone volume0.00.00.10.20.2-0.1-0.1-0.1-0.00.1-0.10.4
Breakpoint value in progressive ratio session0.10.10.5-0.2-0.50.20.30.3-0.30.00.3-0.7
Number of licking bursts0.10.10.20.40.3-0.4-0.4-0.40.40.4-0.40.2
Context. condit. distance diff. score0.00.00.0-0.00.00.00.00.0-0.1-0.10.00.2
Locomotion velocity, session 10.10.10.10.30.3-0.2-0.3-0.30.10.3-0.30.3
Locomotion distance, session 10.81.01.8-1.0-1.01.01.01.0-1.3-0.90.8-0.9
Locomotion velocity, session 20.30.40.50.70.7-0.6-0.6-0.60.40.7-0.70.7
Locomotion distance, session 20.00.00.10.20.2-0.1-0.1-0.1-0.20.1-0.30.4
Locomotion velocity, session 30.10.10.3-0.1-0.10.30.30.3-0.5-0.20.20.1
Locomotion distance, session 31.11.21.61.21.2-1.0-1.0-1.00.81.0-1.21.3
Stereotopy head waving bouts, day 30.00.10.1-0.3-0.30.20.20.2-0.2-0.30.2-0.2
Stereotopy head waving duration, day 30.30.40.5-0.7-0.60.60.60.6-0.5-0.70.6-0.5
Locomotion velocity, session 70.30.30.4-0.5-0.40.60.60.6-0.6-0.60.6-0.1
Locomotion distance, session 70.60.81.50.91.0-0.8-0.8-0.80.70.8-0.91.2
Stereotopy head waving bouts, day 70.10.10.20.30.3-0.3-0.3-0.30.40.4-0.20.2
Stereotopy head waving duration, day 70.20.20.3-0.5-0.50.50.50.5-0.4-0.40.5-0.6
Locomotion velocity, session 80.20.20.7-0.4-0.40.50.50.5-0.8-0.40.3-0.3
Locomotion distance, session 80.20.20.8-0.4-0.30.60.50.5-0.9-0.50.3-0.0
Degree of sensitization distance1.41.41.6-1.3-1.21.21.21.2-1.0-1.11.2-1.2
Degree of sensitization stereotypy0.00.00.00.1-0.0-0.00.00.00.20.20.2-0.2
Conditioned locomotion3.03.54.11.91.9-1.9-1.9-1.92.01.8-1.81.9
Cocaine response after cond. corrected0.30.30.4-0.6-0.60.50.50.5-0.4-0.70.5-0.6
Cocaine response after cond. not corrected1.92.12.3-1.5-1.51.41.41.4-1.4-1.51.3-1.4
Cocaine response before conditioning1.01.21.9-1.1-1.01.21.21.2-1.4-1.11.0-0.9
Saline control response1.62.12.6-1.6-1.51.41.41.4-1.3-1.61.4-1.3
Bone: connectivity density0.20.30.40.50.5-0.6-0.5-0.60.60.5-0.40.5
Bone: cortical apparent density0.30.40.50.70.6-0.6-0.6-0.60.70.7-0.60.6
Bone: cortical area0.20.30.70.50.6-0.4-0.4-0.40.40.4-0.40.9
Bone: cortical porosity0.00.00.10.00.0-0.2-0.1-0.10.40.00.0-0.1
Bone: cortical porosity0.10.10.30.20.2-0.4-0.4-0.40.60.2-0.20.2
Bone: cortical thickness0.10.10.2-0.3-0.20.40.40.4-0.4-0.40.40.0
Bone: cortical thickness0.00.00.0-0.1-0.10.10.10.1-0.1-0.10.1-0.0
Bone: cortical tissue density0.30.40.50.70.6-0.6-0.6-0.60.70.7-0.60.6
Condit. Reinf. active minus inactive responses0.10.10.2-0.3-0.30.30.40.4-0.2-0.30.4-0.2
Condit. Reinf. active-inactive response ratio0.20.30.4-0.5-0.50.50.50.5-0.4-0.50.6-0.5
Condit. Reinf. active responses0.00.00.10.20.2-0.2-0.1-0.10.20.2-0.00.3
Condit. Reinf. inactive responses0.70.91.11.01.0-0.9-0.9-0.90.91.0-0.81.0
Incentive salience index mean0.10.10.10.30.3-0.2-0.2-0.20.20.3-0.30.4
Condit. Reinf. lever presses1.62.22.41.61.5-1.4-1.5-1.51.21.4-1.61.5
Condit. Reinf. active minus inactive responses2.32.83.2-1.8-1.81.71.61.7-1.8-1.71.4-1.7
Condit. Reinf. active-inactive response ratio1.81.92.2-1.5-1.51.41.31.3-1.4-1.41.2-1.4
Condit. Reinf. active responses1.92.62.9-1.7-1.71.61.61.6-1.6-1.61.4-1.6
Condit. Reinf. inactive responses0.00.00.10.20.2-0.1-0.1-0.10.10.1-0.20.2
Condit. Reinf. lever presses2.63.64.1-2.0-2.01.91.81.8-2.0-1.91.7-1.8
Condit. Reinf. lever reinforcers received2.13.03.5-1.9-1.81.71.71.7-1.8-1.81.5-1.6
Conditioned reinforcement - actives0.20.20.60.30.2-0.5-0.5-0.5-0.00.1-0.70.2
Conditioned reinforcement - inactives0.80.91.41.01.0-1.0-1.0-1.00.80.8-1.01.2
Conditioned locomotion0.20.30.70.50.4-0.6-0.7-0.60.30.5-0.80.1
Patch foraging indifference point 0 sec1.01.62.2-1.4-1.31.31.31.3-1.2-1.51.2-0.9
Patch foraging indifference point AUC0.10.20.4-0.5-0.50.30.30.3-0.3-0.30.2-0.7
Delay disc. indifference point, 0s delay0.00.00.1-0.0-0.1-0.2-0.2-0.2-0.10.0-0.2-0.3
Delay disc. indifference point, 16s delay1.21.21.61.11.2-1.1-1.1-1.11.11.0-0.91.3
Delay disc. indifference point, 2s delay0.30.30.30.50.6-0.6-0.6-0.60.40.5-0.50.6
Delay disc. indifference point, 24s delay1.00.91.41.01.0-0.9-0.9-0.91.00.8-0.81.2
Delay disc. indifference point, 4s delay2.12.22.41.51.5-1.6-1.6-1.61.51.5-1.41.3
Delay disc. indifference point, 8s delay2.02.12.21.41.4-1.5-1.5-1.51.51.4-1.31.3
Indifference point function ln k0.30.51.20.90.9-0.4-0.5-0.50.20.6-0.71.1
Indifference point function log k0.30.51.20.90.9-0.4-0.5-0.50.20.6-0.71.1
Patch foraging total patch changes 0 sec1.22.02.7-1.5-1.41.51.41.5-1.3-1.61.3-1.1
Patch foraging total patch changes 12 sec1.01.31.8-1.3-1.21.11.11.1-0.8-1.21.1-1.1
Patch foraging total patch changes 18 sec3.34.35.4-2.3-2.31.91.91.9-2.0-2.21.8-2.2
Patch foraging total patch changes 24 sec3.44.15.0-2.2-2.22.02.02.0-1.9-2.02.0-2.1
Patch foraging total patch changes 6 sec0.10.20.3-0.5-0.50.40.40.4-0.2-0.40.4-0.4
Patch foraging time to switch 0 sec0.20.30.40.60.5-0.5-0.5-0.50.60.5-0.20.5
Patch foraging water rate 0 sec0.20.30.5-0.6-0.60.50.50.5-0.7-0.60.2-0.5
Patch foraging water rate 12 sec0.30.40.6-0.5-0.60.70.70.7-0.8-0.40.4-0.7
Patch foraging water rate 18 sec0.00.00.1-0.0-0.00.10.10.1-0.2-0.20.00.1
Patch foraging water rate 24 sec0.71.01.4-1.0-1.11.01.01.0-1.0-0.90.8-1.2
Patch foraging water rate 6 sec0.20.40.7-0.5-0.50.70.60.6-0.8-0.40.6-0.5
Seeking ratio, delayed vs. immediate footshock2.02.43.11.51.3-1.7-1.7-1.71.51.5-1.70.7
Distance traveled before self-admin0.00.00.2-0.10.00.10.10.1-0.4-0.20.10.2
Distance traveled after self-admin0.30.40.80.70.8-0.4-0.4-0.40.40.5-0.50.9
Extensor digitorum longus weight0.10.60.70.80.7-0.8-0.8-0.80.70.7-0.90.7
Bone: elastic displacement0.10.10.2-0.4-0.40.20.20.2-0.2-0.40.2-0.3
Bone: elastic work0.50.70.9-0.9-0.80.80.80.8-1.0-0.90.7-0.5
Bone: endosteal estimation0.10.20.4-0.5-0.50.50.50.5-0.4-0.60.5-0.3
Bone: endosteal perimeter1.32.73.51.71.8-1.6-1.6-1.61.51.5-1.71.9
Epididymis fat weight0.40.91.6-1.0-1.10.80.80.8-0.8-0.90.9-1.3
Delta time in closed arm before/after self-admin0.10.10.10.40.3-0.4-0.4-0.40.30.4-0.30.1
Delta time in open arm before/after self-admin0.20.20.3-0.4-0.10.60.60.6-0.4-0.50.50.4
Diff in mean of infusions in LGA sessions0.00.00.10.0-0.0-0.1-0.1-0.10.20.2-0.0-0.2
Delay discount exponential model param2.42.52.8-1.6-1.61.71.71.7-1.6-1.61.5-1.4
Extinction: sum of active levers before priming0.10.10.2-0.4-0.30.20.10.2-0.4-0.20.1-0.3
Active lever presses in extinction session 60.30.30.8-0.4-0.30.60.60.6-0.9-0.40.5-0.1
Bone: final force0.71.21.4-1.1-1.01.21.11.1-1.2-1.11.1-0.8
Bone: final moment1.01.61.9-1.3-1.21.31.31.3-1.4-1.31.3-0.9
Food consumed during 24 hour testing period1.51.82.0-1.4-1.31.31.31.3-1.4-1.41.2-1.2
Glucose0.30.51.0-0.8-0.80.60.60.6-0.6-0.70.6-1.0
Heart weight2.13.03.4-1.7-1.71.81.81.8-1.7-1.61.7-1.6
Delay discount hyperbolic model param2.32.52.8-1.6-1.61.71.71.7-1.6-1.61.5-1.4
Intermittent access intake day 1-15 change0.70.72.10.80.9-0.7-0.7-0.70.50.5-0.81.4
Intermittent access intake escalation0.60.62.10.70.9-0.6-0.6-0.60.40.3-0.71.5
Intermittent access intake escalation 20.10.10.6-0.10.10.20.20.2-0.4-0.40.10.8
Intermitt. access day 1 inactive lever presses0.00.00.00.10.1-0.1-0.1-0.10.00.1-0.00.1
Intermitt. access day 15 inactive lever presses0.91.01.41.01.1-0.9-0.9-0.90.91.0-0.81.2
Intermitt. access escalation Index0.00.00.10.00.10.00.00.0-0.0-0.00.00.2
Intermittent access day 1 total infusions0.00.00.00.10.1-0.1-0.1-0.1-0.00.0-0.20.1
Intermittent access day 15 total infusions0.40.41.60.50.7-0.5-0.5-0.50.20.2-0.71.3
Intermittent access terminal intake (last 3 days)0.20.21.00.30.5-0.3-0.3-0.3-0.0-0.0-0.51.0
Intermittent access total infusions0.40.51.30.60.8-0.6-0.7-0.60.30.3-0.81.1
Intermittent access day 1 locomotion0.10.10.10.30.3-0.3-0.3-0.30.30.4-0.30.2
Intermittent access day 15 total locomotion0.60.61.00.80.9-0.7-0.7-0.70.60.7-0.81.0
Intermittent access total locomotion1.11.21.51.11.1-1.1-1.1-1.10.91.0-1.21.1
Intermittent access standard deviation0.20.20.4-0.5-0.30.50.50.5-0.6-0.70.40.2
Left kidney weight0.51.41.9-1.1-1.11.31.31.3-1.4-1.01.1-1.1
Right kidney weight0.10.30.5-0.4-0.40.60.60.6-0.7-0.60.4-0.2
Cocaine induced anxiety0.60.70.80.80.8-0.8-0.8-0.80.70.7-0.80.9
Post-drug Anxiety0.30.30.40.60.6-0.6-0.5-0.50.70.7-0.40.5
Baseline Anxiety0.20.20.30.50.5-0.4-0.4-0.40.50.5-0.30.5
Tail length7.021.223.4-4.8-4.64.74.74.7-4.5-4.64.7-4.0
Length with tail9.434.536.6-6.0-5.96.16.16.0-5.8-5.85.9-5.1
Length without tail6.514.215.0-3.8-3.83.83.83.8-3.9-3.83.6-3.5
Times rat made contact with spout0.40.40.5-0.7-0.70.60.70.7-0.6-0.70.7-0.7
Lifetime Intake0.30.30.70.50.6-0.5-0.6-0.60.30.3-0.70.8
Liver weight, left0.10.10.3-0.4-0.40.20.30.2-0.1-0.30.5-0.5
Liver weight, right1.32.12.4-1.5-1.51.41.41.4-1.4-1.31.6-1.5
Locomotor activity5.79.110.1-3.1-3.03.23.13.2-3.2-3.12.8-2.5
Locomotor testing distance5.69.310.8-3.1-3.03.23.23.2-3.3-3.02.9-2.6
Locomotor testing rearing0.30.50.6-0.6-0.60.70.70.7-0.8-0.70.6-0.5
Locomotion in novel chamber0.10.10.40.20.1-0.4-0.5-0.50.20.2-0.6-0.3
Locomotion in novel chamber post-restriction1.01.22.0-1.1-1.21.01.01.0-1.2-1.00.8-1.4
Fecal boli incidents, locomotor time 10.50.50.9-0.7-0.80.70.70.7-0.7-0.80.6-0.9
Change in fecal boli incidents, locomotor task0.10.10.6-0.3-0.40.20.20.2-0.2-0.20.2-0.8
Time >=10cm from walls, locomotor time 10.20.20.30.40.4-0.4-0.4-0.40.60.5-0.30.3
Bouts of movement, locomotor time 10.00.00.2-0.2-0.20.10.10.1-0.20.10.1-0.5
Total resting periods, locomotor time 10.10.10.4-0.2-0.30.10.10.1-0.30.00.1-0.6
Rest time, locomotor task time 10.40.40.70.50.3-0.8-0.8-0.80.40.7-0.9-0.3
Distance moved, locomotor task time 11.41.51.9-1.3-1.21.31.31.3-1.1-1.21.4-0.9
Vertical activity count, locomotor time 10.60.70.9-0.9-0.80.90.90.9-0.4-0.61.0-0.8
Time >=10cm from walls, locomotor time 21.51.61.7-1.2-1.21.31.31.3-1.2-1.21.3-1.3
Bouts of movement, locomotor time 20.10.10.2-0.10.00.10.10.1-0.5-0.40.00.2
Total resting periods, locomotor time 20.00.00.20.20.2-0.1-0.1-0.1-0.2-0.2-0.20.4
Rest time, locomotor task time 20.00.00.1-0.0-0.1-0.1-0.1-0.10.00.0-0.2-0.4
Distance moved, locomotor task time 20.60.81.2-0.9-0.71.01.01.0-0.8-0.71.1-0.4
Vertical activity count, locomotor time 20.00.00.1-0.1-0.00.20.20.20.10.00.30.1
Light reinforcement 10.61.11.2-1.0-1.01.11.11.1-0.9-0.91.1-1.0
Light reinforcement 20.20.30.60.70.7-0.4-0.4-0.40.40.8-0.40.6
Bone: marrow area0.10.20.4-0.5-0.50.50.50.5-0.5-0.60.5-0.3
Bone: maximum diameter0.50.91.31.11.1-0.9-0.9-0.90.80.9-1.01.1
Bone: maximum force0.61.11.3-1.1-1.01.11.11.1-1.1-1.11.1-0.7
Bone: maximum moment0.71.31.5-1.2-1.11.21.21.2-1.2-1.21.2-0.7
Mean time between licks in bursts1.01.41.91.21.2-1.2-1.2-1.21.11.0-1.41.1
Mean num. licks in bursts0.50.60.7-0.8-0.80.80.80.8-0.8-0.80.8-0.6
Cd content in liver2.73.03.7-1.9-1.91.71.71.7-1.5-1.81.7-1.8
Co content in liver0.10.10.60.10.20.10.10.1-0.2-0.10.10.8
Cu content in liver4.85.87.1-2.6-2.62.32.32.3-2.2-2.62.2-2.7
Fe content in liver2.12.53.6-1.8-1.81.41.51.5-1.2-1.61.5-1.9
K content in liver0.80.81.1-0.9-0.90.80.80.8-1.0-0.90.8-1.1
Mg content in liver0.00.00.10.00.00.0-0.0-0.0-0.3-0.0-0.1-0.0
Mn content in liver0.60.61.3-0.8-0.60.90.80.8-1.1-0.80.7-0.4
Na content in liver0.40.40.6-0.7-0.70.60.60.6-0.4-0.70.7-0.7
Rb content in liver1.31.62.0-1.4-1.41.21.21.3-0.9-1.41.4-1.2
Se content in liver0.00.00.2-0.2-0.20.10.10.1-0.0-0.00.2-0.4
Sr content in liver0.00.00.10.00.10.00.00.0-0.30.1-0.10.1
Zn content in liver5.05.56.7-2.5-2.52.32.22.2-2.4-2.32.1-2.6
Bone: minimum diameter0.40.81.50.91.0-0.8-0.8-0.80.70.8-0.81.2
Time in familiar zone, hab. session 11.21.11.51.01.1-1.1-1.1-1.11.20.8-1.01.2
Time in novel zone, hab. session 10.50.40.6-0.7-0.60.70.70.7-0.7-0.50.8-0.6
Total zone transitions, hab. session 10.50.61.2-0.7-0.70.90.90.9-1.1-0.80.7-0.5
Total locomotion distance, hab. session 10.20.30.4-0.5-0.50.60.50.5-0.6-0.50.5-0.6
Locomotion velocity, hab. session 10.20.30.4-0.6-0.60.60.60.6-0.7-0.50.5-0.6
Time in familiar zone, hab. session 20.40.50.60.70.7-0.7-0.7-0.70.60.5-0.80.7
Time in novel zone, hab. session 20.00.00.1-0.2-0.20.20.20.2-0.1-0.20.2-0.1
Total zone transitions, hab. session 20.00.10.3-0.1-0.00.20.20.2-0.5-0.10.00.1
Total locomotion distance, hab. session 20.20.30.5-0.5-0.60.50.50.5-0.7-0.40.4-0.7
Locomotion velocity, hab. session 20.10.20.3-0.4-0.40.40.40.4-0.5-0.30.3-0.6
Novel to familiar place preference ratio0.90.91.1-1.0-1.01.00.91.0-0.9-1.00.9-1.0
Novelty place preference0.90.91.1-1.0-1.00.90.90.9-0.9-1.00.9-1.0
Time in novel zone, NPP test1.21.21.5-1.2-1.11.11.11.1-1.0-1.21.0-1.1
Total zone transitions, NPP test2.02.84.9-1.6-1.51.81.71.7-2.2-1.61.5-1.4
Total locomotion distance, NPP test0.91.21.6-1.1-1.11.11.11.1-1.3-1.01.0-1.2
Locomotion velocity, NPP test0.91.31.8-1.1-1.21.21.11.1-1.3-1.01.0-1.2
Intraocular pressure1.21.72.3-1.4-1.51.21.31.3-1.1-1.21.3-1.5
Delta distance traveled before/after self-admin0.40.40.60.70.7-0.5-0.5-0.50.70.6-0.50.8
Delta ambulatory time before/after self-admin0.10.10.3-0.2-0.20.50.50.5-0.1-0.30.5-0.0
Parametrial fat weight1.01.92.0-1.4-1.41.41.41.4-1.3-1.21.4-1.4
Pavlov. Cond. lever latency5.67.18.1-2.8-2.72.72.72.7-2.4-2.72.8-2.4
Pavlov. Cond. magazine entry latency6.98.910.03.23.1-3.0-3.0-3.02.72.9-3.03.0
Pavlov. Cond. change in total contacts1.61.72.01.31.3-1.4-1.4-1.41.31.3-1.41.1
Pavlov. Cond. index score6.88.79.73.13.0-3.0-3.0-3.02.72.9-3.02.7
Pavlov. Cond. latency score6.78.59.63.13.0-2.9-2.9-2.92.72.9-3.02.7
Pavlov. Cond. lever contacts3.33.84.42.12.0-2.0-2.0-2.01.72.0-2.11.7
Pavlov. Cond. magazine entry number7.89.710.8-3.3-3.23.13.13.1-2.9-3.13.2-3.0
Pavlov. Cond. intertrial magazine entries0.40.50.6-0.7-0.70.70.80.8-0.7-0.70.8-0.5
Pavlov. Cond. lever-magazine prob. diff.6.17.58.52.92.8-2.8-2.8-2.82.52.8-2.92.5
Pavlov. Cond. response bias7.49.010.23.23.1-3.0-3.0-3.02.83.0-3.12.8
Pavlov. Cond. lever latency0.50.71.01.00.9-0.8-0.8-0.81.01.0-0.60.7
Pavlov. Cond. magazine entry latency0.10.10.30.30.4-0.3-0.3-0.30.10.2-0.50.4
Pavlov. Cond. change in total contacts2.73.84.5-2.1-2.01.91.91.9-2.1-2.11.7-1.8
Pavlov. Cond. index score0.10.10.3-0.4-0.40.30.30.3-0.5-0.50.1-0.3
Pavlov. Cond. latency score0.10.10.2-0.3-0.30.30.20.2-0.5-0.40.1-0.2
Pavlov. Cond. lever contacts1.11.61.9-1.4-1.31.21.21.2-1.3-1.41.0-1.2
Pavlov. Cond. magazine entry number0.30.30.7-0.5-0.60.60.60.6-0.4-0.30.8-0.7
Pavlov. Cond. intertrial magazine entries0.40.50.70.80.8-0.7-0.6-0.60.80.7-0.60.8
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.4-0.30.30.30.3-0.5-0.50.1-0.2
Pavlov. Cond. response bias0.10.10.3-0.4-0.40.30.30.3-0.5-0.60.1-0.3
Time in closed arm before self-admin1.82.03.1-1.4-1.31.51.41.5-1.8-1.61.2-1.0
Time in closed arm after self-admin0.00.00.1-0.0-0.30.10.10.1-0.4-0.10.1-0.2
Time in open arm before self-admin1.31.42.01.21.1-1.2-1.2-1.21.41.4-0.90.8
Time in open arm after self-admin0.40.41.50.50.9-0.4-0.4-0.40.50.4-0.41.2
Bone: periosteal estimation0.00.00.1-0.1-0.00.20.20.2-0.2-0.30.10.3
Bone: periosteal perimeter1.32.23.21.61.6-1.4-1.4-1.41.41.4-1.51.8
Bone: post-yield work0.00.00.1-0.1-0.10.20.20.2-0.2-0.20.10.0
Progressive ratio test 1 active lever presses0.00.00.1-0.1-0.1-0.0-0.0-0.0-0.3-0.2-0.20.0
Progressive ratio test 1 breakpoint0.00.00.10.00.0-0.1-0.1-0.1-0.2-0.1-0.20.1
Progressive ratio test 1 inactive lever presses0.30.30.50.50.5-0.6-0.6-0.60.30.4-0.70.4
Progressive ratio test 2 active lever presses0.90.91.21.01.0-1.0-1.0-1.00.70.8-1.11.1
Progressive ratio test 2 breakpoint0.70.81.10.90.9-0.9-0.9-0.90.70.8-1.01.0
Progressive ratio test 2 inactive lever presses2.02.33.51.51.6-1.5-1.5-1.51.11.2-1.61.9
Incentive Sensitization - Responses1.91.92.21.51.4-1.4-1.4-1.41.41.5-1.41.2
Incentive Sensitization - Breakpoint1.81.92.21.51.4-1.4-1.3-1.31.31.4-1.41.3
Sum of active levers in priming session hrs 5-60.50.50.6-0.8-0.60.70.70.7-0.7-0.60.7-0.7
Progressive ratio4.24.85.5-2.3-2.32.12.02.1-2.3-2.32.0-2.3
Food seeking constrained by brief footshock0.91.11.91.11.1-1.0-1.0-1.00.90.8-1.11.4
Seeking ratio, punishment vs. effort6.47.89.13.03.0-2.7-2.6-2.72.72.7-2.73.0
Retroperitoneal fat weight0.51.71.9-1.3-1.31.41.41.4-1.1-1.31.4-1.0
Reaction time number correct0.40.61.10.80.9-0.6-0.6-0.60.60.6-0.81.0
Reaction time mean minus median0.00.10.2-0.2-0.20.20.20.2-0.2-0.00.1-0.4
Reaction time mean minus median AUC0.30.41.0-0.6-0.70.50.50.5-0.6-0.40.4-1.0
Reaction time num false alarms0.40.51.40.70.8-0.6-0.6-0.60.60.5-0.61.2
Reaction time num false alarms AUC0.10.20.90.40.5-0.3-0.2-0.20.40.3-0.20.9
Reaction time trials correct on left0.40.61.10.80.9-0.6-0.6-0.60.60.6-0.81.0
Reaction time trials on left0.40.61.10.90.9-0.7-0.7-0.70.70.7-0.81.1
Reaction time mean0.00.00.1-0.2-0.20.10.10.1-0.1-0.20.1-0.3
Reaction time mean AUC0.00.00.0-0.1-0.10.00.00.00.0-0.10.0-0.2
Median of all reaction times0.00.00.0-0.2-0.10.10.10.10.0-0.20.2-0.1
Reaction time omissions0.20.30.80.40.4-0.6-0.6-0.60.90.5-0.40.2
Reaction time false alarm rate0.00.10.30.20.3-0.1-0.1-0.10.30.1-0.10.5
Reaction time premature initiation rate1.82.42.7-1.6-1.61.61.61.6-1.3-1.31.6-1.6
Reaction time premature initiations0.70.91.3-1.0-0.91.11.11.1-0.8-0.81.0-0.8
Std. dev. reaction times0.10.10.3-0.4-0.40.40.40.4-0.4-0.40.2-0.5
Reaction time trials completed0.40.61.10.90.9-0.7-0.7-0.70.70.7-0.81.1
Reaction time trials AUC0.50.71.31.01.0-0.8-0.8-0.80.70.7-0.91.1
Run reversals in cocaine runway, females2.32.22.81.61.6-1.4-1.4-1.41.51.7-1.21.6
Run reversals in cocaine runway, males0.40.30.6-0.5-0.50.70.70.7-0.3-0.30.8-0.6
Latency to leave start box in cocaine runway0.40.51.2-0.7-0.80.50.50.5-0.3-0.60.8-1.1
Latency to leave start box in cocaine runway, F1.21.31.4-1.2-1.21.21.21.2-1.2-1.21.1-1.0
Latency to leave start box in cocaine runway, M0.30.30.60.40.2-0.6-0.6-0.60.80.6-0.2-0.4
Std. dev. time between licks in bursts3.84.55.22.22.2-2.1-2.1-2.11.91.9-2.32.2
Total sessions with >9 infusions0.00.00.10.20.0-0.2-0.2-0.20.20.2-0.3-0.1
Short access day 1 total inactive lever presses2.93.34.11.81.8-1.9-1.9-1.91.51.6-2.01.7
Short access day 10 total inactive lever presses0.00.00.10.20.2-0.1-0.1-0.10.20.20.00.2
Short access day 1 total infusions0.70.81.00.90.7-1.0-1.0-1.00.90.9-1.00.4
Short access day 10 total infusions0.00.00.10.10.1-0.1-0.2-0.1-0.1-0.1-0.30.3
Short access total infusions0.40.40.60.70.6-0.7-0.7-0.70.50.6-0.80.6
Short access day 1 locomotion0.00.00.10.10.0-0.2-0.2-0.20.10.1-0.3-0.2
Short access day 10 total locomotion0.10.10.3-0.3-0.40.20.20.2-0.3-0.20.1-0.6
Short access total locomotion0.00.00.2-0.0-0.2-0.1-0.1-0.1-0.10.1-0.2-0.5
One hour access (0.3 mA shock)0.10.20.70.30.4-0.3-0.3-0.30.00.0-0.50.8
Compulsive drug intake0.00.00.10.10.1-0.1-0.1-0.10.20.20.00.0
One hour access (shock baseline)0.10.10.60.10.3-0.1-0.2-0.2-0.2-0.2-0.40.8
Social response proportion0.30.30.6-0.5-0.50.60.70.7-0.4-0.50.8-0.4
Social responses0.30.40.4-0.6-0.50.70.70.7-0.7-0.50.6-0.4
Social time0.81.01.91.11.2-0.9-0.8-0.81.01.2-0.61.4
Soleus weight3.911.613.1-3.5-3.43.43.43.4-3.6-3.33.3-3.2
Bone: stiffness0.10.20.3-0.4-0.30.50.50.5-0.4-0.40.5-0.2
Tibialis anterior weight0.00.00.1-0.2-0.20.20.20.2-0.2-0.20.1-0.1
Time to tail flick, vehicle, before self-admin2.62.63.7-1.7-1.81.41.41.4-1.6-1.41.6-1.9
Time to tail flick, vehicle, after self-admin0.50.50.7-0.8-0.70.70.70.7-0.5-0.80.6-0.8
Time to tail flick, test, before self-admin0.00.00.10.10.00.10.10.10.30.40.3-0.2
Time to tail flick, test, after self-admin0.10.10.10.20.2-0.4-0.4-0.40.20.1-0.20.1
Delta time to tail flick, vehicle, before/after SA0.70.60.90.80.8-0.7-0.7-0.70.90.7-0.90.8
Delta time to tail flick, test, before/after SA0.10.10.30.20.2-0.4-0.4-0.40.0-0.1-0.60.3
Tibia length6.518.322.5-4.3-4.24.44.44.4-4.7-4.24.1-3.8
Ambulatory time before self-admin0.10.10.30.20.2-0.2-0.2-0.2-0.20.0-0.20.5
Ambulatory time after self-admin0.10.10.40.50.5-0.1-0.1-0.10.10.3-0.10.7
Bone: tissue strength3.13.03.3-1.8-1.71.81.81.8-1.8-1.81.7-1.4
Total heroin consumption1.01.21.5-1.1-1.01.21.21.2-1.1-1.01.1-0.8
Bone: trabecular number0.60.91.21.01.1-0.9-0.9-0.90.80.9-1.01.1
Bone: trabecular spacing1.31.72.0-1.3-1.31.31.31.3-1.2-1.21.4-1.3
Bone: trabecular thickness0.00.00.0-0.1-0.10.10.10.1-0.2-0.10.1-0.2
Bone: trabecular tissue density0.20.20.3-0.4-0.40.60.60.6-0.5-0.30.5-0.4
Water consumed over 24 hours0.00.00.00.20.1-0.1-0.1-0.10.00.1-0.20.2
Number of responses in last shaping day0.70.81.50.80.9-0.8-0.8-0.80.70.6-0.91.2