Hub : Genes

Prr5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye mRNA stability Prr5 0.26 0.18 5.0e-03 0.06 0.1 0.07 0.09 4.6e-02 1.4e-02 3.4e-02 1.9e-02
2 LHb gene expression Prr5 0.16 0.11 4.0e-03 0.1 0.05 0.02 0.05 2.2e-03 2.7e-02 8.8e-02 2.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.71.21.5-1.01.2
Area under the delay curve2.12.53.4-1.91.2
BMI with tail1.75.96.72.2-2.6
BMI without tail0.31.01.01.0-0.9
Body weight1.66.97.42.5-2.7
Weight adjusted by age0.91.41.41.2-1.2
Bone surface0.20.40.5-0.50.7
Bone volume0.30.50.7-0.50.8
Breakpoint value in progressive ratio session0.40.40.50.6-0.7
Number of licking bursts0.50.81.3-0.61.1
Context. condit. distance diff. score3.03.63.81.9-1.8
Locomotion velocity, session 12.02.12.31.4-1.5
Locomotion distance, session 10.10.10.1-0.30.3
Locomotion velocity, session 25.46.26.52.5-2.5
Locomotion distance, session 20.00.10.1-0.3-0.1
Locomotion velocity, session 32.83.24.32.1-1.5
Locomotion distance, session 30.10.10.10.40.3
Stereotopy head waving bouts, day 32.32.73.01.6-1.7
Stereotopy head waving duration, day 34.75.65.62.4-2.3
Locomotion velocity, session 71.01.11.21.1-0.9
Locomotion distance, session 70.00.00.0-0.10.2
Stereotopy head waving bouts, day 75.15.76.82.6-2.2
Stereotopy head waving duration, day 72.83.34.12.0-1.6
Locomotion velocity, session 810.813.013.53.5-3.7
Locomotion distance, session 82.23.23.51.9-1.7
Degree of sensitization distance0.40.40.80.2-0.9
Degree of sensitization stereotypy3.03.34.12.0-1.6
Conditioned locomotion0.20.30.3-0.50.6
Cocaine response after cond. corrected0.10.10.20.00.4
Cocaine response after cond. not corrected0.20.20.40.20.6
Cocaine response before conditioning0.30.40.6-0.40.8
Saline control response0.10.10.20.20.4
Bone: connectivity density0.30.40.6-0.50.7
Bone: cortical apparent density1.41.92.2-1.51.3
Bone: cortical area0.40.70.80.9-0.7
Bone: cortical porosity0.00.00.00.1-0.2
Bone: cortical porosity0.30.30.40.4-0.6
Bone: cortical thickness0.30.50.7-0.80.5
Bone: cortical thickness0.10.10.1-0.3-0.1
Bone: cortical tissue density1.11.41.7-1.31.1
Condit. Reinf. active minus inactive responses1.51.72.5-1.61.0
Condit. Reinf. active-inactive response ratio1.41.52.1-1.41.0
Condit. Reinf. active responses1.51.92.4-1.61.2
Condit. Reinf. inactive responses0.20.30.3-0.50.5
Incentive salience index mean1.31.72.1-1.51.1
Condit. Reinf. lever presses0.20.30.4-0.60.5
Condit. Reinf. active minus inactive responses0.10.10.10.0-0.4
Condit. Reinf. active-inactive response ratio0.00.00.0-0.1-0.0
Condit. Reinf. active responses0.91.21.80.9-1.3
Condit. Reinf. inactive responses1.41.82.41.1-1.6
Condit. Reinf. lever presses1.11.51.81.1-1.4
Condit. Reinf. lever reinforcers received0.40.60.90.5-1.0
Conditioned reinforcement - actives0.00.10.1-0.30.2
Conditioned reinforcement - inactives0.10.10.10.3-0.3
Conditioned locomotion1.01.32.11.5-0.7
Patch foraging indifference point 0 sec0.10.20.3-0.30.6
Patch foraging indifference point AUC0.20.30.4-0.70.4
Delay disc. indifference point, 0s delay0.20.20.20.3-0.5
Delay disc. indifference point, 16s delay2.02.23.4-1.81.1
Delay disc. indifference point, 2s delay1.11.31.6-1.21.0
Delay disc. indifference point, 24s delay0.20.30.5-0.70.0
Delay disc. indifference point, 4s delay1.01.11.8-1.30.7
Delay disc. indifference point, 8s delay2.42.83.6-1.91.4
Indifference point function ln k1.01.72.51.6-1.0
Indifference point function log k1.01.72.51.6-1.0
Patch foraging total patch changes 0 sec0.20.30.5-0.40.7
Patch foraging total patch changes 12 sec0.10.10.2-0.1-0.4
Patch foraging total patch changes 18 sec1.11.62.2-1.01.5
Patch foraging total patch changes 24 sec0.10.30.50.7-0.0
Patch foraging total patch changes 6 sec0.50.80.8-0.90.9
Patch foraging time to switch 0 sec0.00.00.10.2-0.2
Patch foraging water rate 0 sec0.20.50.60.8-0.6
Patch foraging water rate 12 sec0.40.91.71.3-0.2
Patch foraging water rate 18 sec0.00.00.10.10.2
Patch foraging water rate 24 sec1.52.02.31.5-1.3
Patch foraging water rate 6 sec0.20.30.5-0.20.7
Seeking ratio, delayed vs. immediate footshock1.72.02.8-1.11.7
Distance traveled before self-admin0.30.50.5-0.60.7
Distance traveled after self-admin0.20.20.30.40.5
Extensor digitorum longus weight0.51.92.41.5-1.2
Bone: elastic displacement1.51.72.01.4-1.2
Bone: elastic work5.97.78.42.9-2.6
Bone: endosteal estimation3.98.610.33.2-2.6
Bone: endosteal perimeter3.06.48.93.0-2.0
Epididymis fat weight0.51.72.80.7-1.7
Delta time in closed arm before/after self-admin0.50.50.7-0.90.4
Delta time in open arm before/after self-admin2.22.24.02.0-0.6
Diff in mean of infusions in LGA sessions0.10.20.3-0.60.1
Delay discount exponential model param2.22.53.51.9-1.2
Extinction: sum of active levers before priming0.90.91.70.4-1.3
Active lever presses in extinction session 60.40.40.70.3-0.8
Bone: final force0.30.50.80.4-0.9
Bone: final moment0.60.91.50.6-1.2
Food consumed during 24 hour testing period1.31.82.11.2-1.5
Glucose2.23.53.8-2.01.8
Heart weight2.64.04.61.8-2.1
Delay discount hyperbolic model param2.22.53.41.8-1.3
Intermittent access intake day 1-15 change0.10.30.5-0.30.7
Intermittent access intake escalation0.20.30.5-0.40.7
Intermittent access intake escalation 21.31.41.4-1.21.2
Intermitt. access day 1 inactive lever presses0.10.30.40.3-0.6
Intermitt. access day 15 inactive lever presses0.10.20.4-0.1-0.6
Intermitt. access escalation Index0.40.60.6-0.70.8
Intermittent access day 1 total infusions0.71.11.31.1-0.9
Intermittent access day 15 total infusions0.10.10.20.50.1
Intermittent access terminal intake (last 3 days)0.10.20.30.5-0.2
Intermittent access total infusions0.50.60.80.9-0.6
Intermittent access day 1 locomotion0.00.00.10.30.1
Intermittent access day 15 total locomotion0.81.42.31.5-0.7
Intermittent access total locomotion1.92.22.91.7-1.3
Intermittent access standard deviation0.10.20.30.4-0.6
Left kidney weight17.179.583.38.7-9.1
Right kidney weight18.182.392.68.5-9.6
Cocaine induced anxiety1.11.62.50.8-1.6
Post-drug Anxiety0.20.20.3-0.5-0.3
Baseline Anxiety2.22.63.0-1.51.7
Tail length0.20.81.1-0.71.1
Length with tail0.21.01.01.0-1.0
Length without tail1.13.55.01.4-2.2
Times rat made contact with spout0.30.30.50.4-0.7
Lifetime Intake0.81.01.31.1-0.8
Liver weight, left0.40.70.70.8-0.8
Liver weight, right0.10.20.20.5-0.4
Locomotor activity1.21.92.31.5-1.2
Locomotor testing distance0.20.40.6-0.40.8
Locomotor testing rearing0.10.20.30.5-0.2
Locomotion in novel chamber0.50.61.10.31.1
Locomotion in novel chamber post-restriction0.50.81.0-0.71.0
Fecal boli incidents, locomotor time 10.30.50.60.8-0.6
Change in fecal boli incidents, locomotor task0.20.10.30.5-0.0
Time >=10cm from walls, locomotor time 10.30.40.40.6-0.6
Bouts of movement, locomotor time 10.10.10.2-0.4-0.2
Total resting periods, locomotor time 10.30.30.6-0.7-0.0
Rest time, locomotor task time 11.01.31.90.8-1.4
Distance moved, locomotor task time 10.20.20.4-0.20.7
Vertical activity count, locomotor time 10.30.81.1-0.71.0
Time >=10cm from walls, locomotor time 20.00.00.1-0.00.3
Bouts of movement, locomotor time 20.50.81.5-1.20.3
Total resting periods, locomotor time 20.50.81.7-1.30.2
Rest time, locomotor task time 20.10.20.3-0.60.1
Distance moved, locomotor task time 21.21.42.21.5-0.8
Vertical activity count, locomotor time 21.11.52.11.5-0.9
Light reinforcement 10.92.34.02.0-0.8
Light reinforcement 22.13.24.12.0-1.5
Bone: marrow area4.08.710.43.2-2.6
Bone: maximum diameter5.09.410.83.3-2.8
Bone: maximum force0.91.62.11.0-1.5
Bone: maximum moment1.42.43.21.2-1.8
Mean time between licks in bursts1.43.53.9-1.72.0
Mean num. licks in bursts1.42.13.11.0-1.8
Cd content in liver0.10.10.20.40.1
Co content in liver0.10.10.10.40.2
Cu content in liver3.44.05.1-1.72.3
Fe content in liver0.20.20.30.6-0.3
K content in liver0.50.50.50.7-0.7
Mg content in liver0.00.00.0-0.0-0.2
Mn content in liver1.11.21.31.2-1.0
Na content in liver1.51.61.6-1.31.2
Rb content in liver0.10.10.2-0.40.2
Se content in liver0.10.10.3-0.10.5
Sr content in liver0.70.60.7-0.80.7
Zn content in liver0.50.50.70.8-0.6
Bone: minimum diameter1.01.83.11.7-0.8
Time in familiar zone, hab. session 10.80.71.01.0-0.7
Time in novel zone, hab. session 10.40.40.4-0.60.7
Total zone transitions, hab. session 11.62.32.5-1.61.5
Total locomotion distance, hab. session 10.20.20.40.6-0.3
Locomotion velocity, hab. session 10.30.40.60.7-0.5
Time in familiar zone, hab. session 20.00.10.10.30.1
Time in novel zone, hab. session 20.20.20.2-0.40.4
Total zone transitions, hab. session 20.40.50.70.6-0.9
Total locomotion distance, hab. session 20.60.70.90.9-0.8
Locomotion velocity, hab. session 20.40.50.50.7-0.7
Novel to familiar place preference ratio0.20.20.30.5-0.4
Novelty place preference0.40.50.70.8-0.5
Time in novel zone, NPP test0.50.50.80.9-0.5
Total zone transitions, NPP test0.00.10.1-0.30.1
Total locomotion distance, NPP test0.60.81.11.1-0.6
Locomotion velocity, NPP test0.20.30.50.7-0.4
Intraocular pressure0.00.00.00.00.1
Delta distance traveled before/after self-admin1.31.32.31.5-0.6
Delta ambulatory time before/after self-admin0.70.91.61.3-0.4
Parametrial fat weight0.81.82.1-1.21.5
Pavlov. Cond. lever latency0.70.91.20.8-1.1
Pavlov. Cond. magazine entry latency3.34.24.6-2.12.0
Pavlov. Cond. change in total contacts3.74.04.1-2.02.0
Pavlov. Cond. index score2.53.23.3-1.81.7
Pavlov. Cond. latency score1.72.12.3-1.41.5
Pavlov. Cond. lever contacts1.92.32.8-1.41.7
Pavlov. Cond. magazine entry number4.35.56.12.5-2.2
Pavlov. Cond. intertrial magazine entries0.10.20.2-0.40.5
Pavlov. Cond. lever-magazine prob. diff.2.93.63.8-1.91.8
Pavlov. Cond. response bias3.94.85.1-2.32.1
Pavlov. Cond. lever latency0.40.60.6-0.80.8
Pavlov. Cond. magazine entry latency0.20.20.4-0.70.2
Pavlov. Cond. change in total contacts0.20.40.60.4-0.8
Pavlov. Cond. index score0.00.00.1-0.0-0.2
Pavlov. Cond. latency score0.00.00.10.0-0.3
Pavlov. Cond. lever contacts0.20.30.40.5-0.6
Pavlov. Cond. magazine entry number0.00.00.00.00.1
Pavlov. Cond. intertrial magazine entries0.20.30.50.2-0.7
Pavlov. Cond. lever-magazine prob. diff.0.00.10.10.1-0.3
Pavlov. Cond. response bias0.00.00.1-0.1-0.2
Time in closed arm before self-admin2.43.03.3-1.71.8
Time in closed arm after self-admin2.52.73.1-1.51.8
Time in open arm before self-admin0.00.00.10.0-0.3
Time in open arm after self-admin3.94.35.12.3-1.9
Bone: periosteal estimation2.75.76.92.6-2.1
Bone: periosteal perimeter2.44.25.92.4-1.5
Bone: post-yield work0.30.50.9-1.00.0
Progressive ratio test 1 active lever presses0.00.00.00.0-0.0
Progressive ratio test 1 breakpoint0.00.00.0-0.20.2
Progressive ratio test 1 inactive lever presses0.20.30.30.5-0.5
Progressive ratio test 2 active lever presses1.01.21.51.0-1.2
Progressive ratio test 2 breakpoint0.91.11.30.9-1.1
Progressive ratio test 2 inactive lever presses0.20.30.30.4-0.6
Incentive Sensitization - Responses1.52.12.71.2-1.6
Incentive Sensitization - Breakpoint1.92.43.21.3-1.8
Sum of active levers in priming session hrs 5-60.50.40.50.7-0.6
Progressive ratio0.71.01.4-1.20.8
Food seeking constrained by brief footshock0.10.10.20.5-0.1
Seeking ratio, punishment vs. effort0.50.80.90.9-0.8
Retroperitoneal fat weight1.98.19.72.6-3.1
Reaction time number correct0.30.50.7-0.50.8
Reaction time mean minus median0.00.00.1-0.00.2
Reaction time mean minus median AUC0.30.70.70.8-0.8
Reaction time num false alarms0.81.11.9-0.51.4
Reaction time num false alarms AUC0.50.71.3-0.31.2
Reaction time trials correct on left0.30.50.7-0.50.8
Reaction time trials on left0.30.60.8-0.60.9
Reaction time mean0.60.91.2-1.10.8
Reaction time mean AUC0.50.81.1-1.00.7
Median of all reaction times1.01.52.0-1.41.0
Reaction time omissions0.60.80.9-1.00.8
Reaction time false alarm rate0.20.30.5-0.10.7
Reaction time premature initiation rate1.21.63.00.5-1.7
Reaction time premature initiations0.40.71.40.2-1.2
Std. dev. reaction times0.10.10.2-0.30.4
Reaction time trials completed0.30.60.8-0.60.9
Reaction time trials AUC0.10.30.4-0.40.7
Run reversals in cocaine runway, females1.71.72.6-0.91.6
Run reversals in cocaine runway, males0.80.91.41.2-0.5
Latency to leave start box in cocaine runway1.41.51.71.2-1.3
Latency to leave start box in cocaine runway, F0.60.70.80.7-0.9
Latency to leave start box in cocaine runway, M1.11.11.21.1-1.0
Std. dev. time between licks in bursts0.10.10.2-0.50.2
Total sessions with >9 infusions2.63.23.61.9-1.7
Short access day 1 total inactive lever presses2.02.62.71.6-1.6
Short access day 10 total inactive lever presses0.82.02.21.5-1.3
Short access day 1 total infusions0.50.71.01.0-0.6
Short access day 10 total infusions0.10.10.10.3-0.4
Short access total infusions1.21.51.61.3-1.2
Short access day 1 locomotion0.20.20.40.6-0.2
Short access day 10 total locomotion0.30.50.7-0.50.8
Short access total locomotion0.00.00.00.20.2
One hour access (0.3 mA shock)0.40.50.70.8-0.5
Compulsive drug intake0.20.20.40.2-0.6
One hour access (shock baseline)0.10.10.30.50.1
Social response proportion0.50.60.60.7-0.7
Social responses0.60.70.90.9-0.8
Social time2.53.54.4-2.11.6
Soleus weight0.30.81.60.3-1.2
Bone: stiffness0.20.30.5-0.70.4
Tibialis anterior weight0.00.00.0-0.1-0.1
Time to tail flick, vehicle, before self-admin0.30.30.50.2-0.7
Time to tail flick, vehicle, after self-admin0.00.00.00.10.1
Time to tail flick, test, before self-admin0.00.00.00.00.0
Time to tail flick, test, after self-admin0.50.50.6-0.80.7
Delta time to tail flick, vehicle, before/after SA0.40.40.40.7-0.6
Delta time to tail flick, test, before/after SA0.40.40.4-0.60.7
Tibia length0.20.40.50.6-0.7
Ambulatory time before self-admin0.20.30.4-0.30.7
Ambulatory time after self-admin0.40.51.00.01.0
Bone: tissue strength0.20.20.40.1-0.6
Total heroin consumption1.72.02.91.1-1.7
Bone: trabecular number1.32.23.0-1.21.7
Bone: trabecular spacing3.34.45.11.9-2.2
Bone: trabecular thickness0.20.30.4-0.40.6
Bone: trabecular tissue density0.40.50.5-0.70.7
Water consumed over 24 hours1.01.41.51.2-1.1
Number of responses in last shaping day1.11.21.2-1.11.1