Hub : Genes

Prr3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain intron excision ratio chr20_2793006_2793683 0.06 0.04 5.6e-04 0.02 0.02 0.01 0.01 3.4e-03 3.5e-03 2.5e-02 2.4e-02
2 IL isoform ratio XM_006255943.4 0.22 0.16 7.2e-03 0.09 0.09 0.05 0.11 3.4e-03 4.6e-03 2.2e-02 1.5e-03
3 pVTA gene expression Prr3 0.22 0.15 2.4e-05 -0 0.06 0.06 0.02 3.8e-01 2.2e-03 2.1e-03 5.7e-02
4 Brain intron excision ratio chr20_2793415_2793683 0.05 0.04 3.8e-03 0 0.02 0 0 2.5e-01 7.9e-03 2.1e-01 1.7e-01
5 OFC gene expression Prr3 0.26 0.15 1.1e-03 0.01 0.11 0.1 0.09 1.9e-01 1.7e-03 2.5e-03 3.6e-03
6 Liver isoform ratio XM_006255942.3 0.02 0.02 7.6e-03 0.01 0.01 0.02 0 2.2e-02 1.3e-02 3.9e-03 1.1e-01
7 BLA gene expression Prr3 0.19 0.15 3.7e-05 0.04 0.05 0.06 0.05 3.8e-03 1.5e-03 2.9e-04 1.7e-03
8 Liver alternative TSS XM_006255942.3 0.03 0.03 6.0e-04 0.02 0.03 0.03 0.01 1.7e-03 7.1e-04 4.7e-04 1.6e-02
9 Liver alternative TSS XM_006255942.3 0.04 0.03 4.4e-04 0.02 0.03 0.03 0.01 1.4e-03 5.8e-04 4.9e-04 1.6e-02
10 NAcc gene expression Prr3 0.09 0.05 2.5e-11 0.08 0.09 0.09 0.09 3.2e-09 1.4e-10 3.4e-10 4.9e-10
11 Liver mRNA stability Prr3 0.04 0.03 1.8e-04 0.03 0.02 0.03 0 1.0e-04 9.3e-04 2.4e-04 2.5e-01
12 NAcc alternative TSS XM_006255942.3 0.02 0.02 4.1e-03 0.01 0.01 0.01 0 2.3e-02 1.8e-02 4.4e-02 8.1e-02
13 PL gene expression Prr3 0.14 0.09 1.8e-11 0.1 0.1 0.09 0.1 9.9e-11 1.1e-10 1.1e-09 4.3e-11
14 Brain gene expression Prr3 0.2 0.15 4.5e-11 0.1 0.11 0.11 0.11 1.1e-09 1.7e-10 2.8e-10 1.0e-10
15 Liver isoform ratio XM_006255943.4 0.05 0.04 3.1e-05 0.04 0.04 0.04 0.04 1.7e-05 3.5e-05 2.2e-05 1.7e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.11.85.01.6-1.6-0.42.0-0.9-2.20.11.91.80.71.6-1.50.50.20.0
Area under the delay curve1.41.54.10.50.02.0-0.6-0.80.61.2-1.6-1.6-1.6-1.51.6-1.2-1.30.0
BMI with tail1.34.27.30.2-0.02.3-1.0-1.41.82.2-2.6-2.6-2.7-2.52.7-2.6-2.50.0
BMI without tail2.24.58.8-0.81.01.9-2.0-0.52.21.5-2.9-3.0-2.5-3.03.0-2.2-2.20.0
Body weight4.217.534.6-2.42.82.8-4.3-0.35.62.2-5.9-5.9-4.4-5.85.6-4.0-4.00.0
Weight adjusted by age2.22.55.1-1.41.81.1-2.00.32.30.6-1.9-1.9-1.4-2.12.1-1.3-1.30.0
Bone surface0.10.20.6-0.60.70.1-0.80.50.2-0.3-0.4-0.4-0.1-0.60.4-0.0-0.10.0
Bone volume0.10.10.50.3-0.30.50.1-0.4-0.30.4-0.1-0.2-0.5-0.30.3-0.5-0.70.0
Breakpoint value in progressive ratio session0.60.71.40.4-0.2-0.50.70.3-1.0-0.51.01.01.01.0-1.21.01.10.0
Number of licking bursts0.70.82.0-1.00.9-0.8-0.61.3-0.4-1.30.30.41.10.5-0.61.11.40.0
Context. condit. distance diff. score5.66.813.0-1.51.5-3.6-0.02.8-1.4-3.32.42.53.52.5-2.93.63.50.0
Locomotion velocity, session 10.30.30.8-0.60.6-0.9-0.30.80.2-0.90.20.30.70.3-0.40.80.60.0
Locomotion distance, session 10.50.71.81.3-1.30.41.3-1.0-1.00.51.00.9-0.00.8-0.6-0.1-0.40.0
Locomotion velocity, session 20.10.20.3-0.60.6-0.5-0.40.60.4-0.5-0.00.00.3-0.3-0.00.40.30.0
Locomotion distance, session 20.20.30.80.4-0.4-0.40.7-0.2-0.7-0.30.90.90.40.6-0.70.40.10.0
Locomotion velocity, session 30.30.40.90.9-0.90.80.6-1.0-0.10.8-0.1-0.1-0.6-0.20.2-0.7-0.80.0
Locomotion distance, session 31.01.12.30.7-0.7-1.01.2-0.0-1.5-0.61.51.51.01.2-1.41.00.70.0
Stereotopy head waving bouts, day 31.31.53.9-1.61.60.3-2.01.01.7-0.3-1.6-1.6-0.6-1.51.4-0.3-0.20.0
Stereotopy head waving duration, day 30.91.02.4-1.21.20.5-1.60.71.3-0.1-1.5-1.4-0.6-1.21.2-0.4-0.30.0
Locomotion velocity, session 73.03.36.50.4-0.4-2.11.40.6-2.2-1.42.52.52.12.4-2.42.01.80.0
Locomotion distance, session 72.73.47.61.2-1.1-1.42.0-0.0-2.6-0.92.82.71.82.3-2.41.61.60.0
Stereotopy head waving bouts, day 71.41.53.3-0.50.51.2-1.1-0.21.81.0-1.6-1.6-1.4-1.71.6-1.2-1.30.0
Stereotopy head waving duration, day 71.82.14.6-0.80.91.2-1.5-0.12.10.9-2.0-2.0-1.5-1.92.0-1.3-1.50.0
Locomotion velocity, session 82.93.48.4-2.82.8-1.9-2.22.91.3-2.5-0.3-0.21.6-0.5-0.31.92.00.0
Locomotion distance, session 82.94.38.7-1.11.0-2.90.22.0-1.3-2.62.12.32.72.0-2.32.82.50.0
Degree of sensitization distance0.60.61.6-0.70.7-0.7-0.41.1-0.2-1.00.40.51.00.5-0.61.01.30.0
Degree of sensitization stereotypy0.90.92.1-0.20.30.9-0.8-0.31.41.0-1.1-1.1-1.1-1.21.3-1.1-1.20.0
Conditioned locomotion0.40.51.3-0.90.90.1-1.10.50.7-0.4-1.0-1.0-0.4-1.00.9-0.3-0.30.0
Cocaine response after cond. corrected0.30.41.00.5-0.50.00.7-0.1-1.0-0.30.90.80.60.8-0.80.50.60.0
Cocaine response after cond. not corrected0.30.40.9-1.01.0-0.1-1.00.90.6-0.7-0.5-0.40.2-0.40.30.40.50.0
Cocaine response before conditioning3.54.310.8-2.32.40.6-3.01.13.3-0.1-2.9-2.8-1.3-2.62.5-0.9-0.80.0
Saline control response1.52.04.41.2-1.21.70.5-1.80.41.9-1.0-1.1-1.9-1.01.3-2.0-2.10.0
Bone: connectivity density1.62.65.10.8-0.8-1.41.60.2-2.3-1.12.22.21.82.0-2.21.61.40.0
Bone: cortical apparent density1.21.64.11.5-1.71.61.1-2.0-0.01.7-0.4-0.5-1.6-0.40.8-1.6-1.50.0
Bone: cortical area1.42.14.2-0.70.51.5-1.3-0.41.50.9-1.9-1.9-1.7-2.02.0-1.6-1.60.0
Bone: cortical porosity0.50.51.40.6-0.41.2-0.0-0.80.51.0-0.7-0.7-1.0-0.60.8-1.0-0.80.0
Bone: cortical porosity0.40.40.9-0.50.60.5-0.90.20.90.1-1.0-0.9-0.5-0.90.9-0.5-0.20.0
Bone: cortical thickness3.65.911.91.6-1.93.40.5-3.00.83.2-1.7-1.9-3.3-2.12.5-3.3-3.40.0
Bone: cortical thickness2.02.35.31.9-1.92.11.2-2.3-0.42.1-0.4-0.6-1.8-0.60.9-1.8-2.00.0
Bone: cortical tissue density1.01.33.31.3-1.51.41.0-1.8-0.01.5-0.4-0.5-1.4-0.40.7-1.4-1.30.0
Condit. Reinf. active minus inactive responses0.60.71.2-0.0-0.1-1.00.50.3-1.0-0.91.11.10.90.9-1.00.90.70.0
Condit. Reinf. active-inactive response ratio0.10.10.40.5-0.60.60.4-0.6-0.30.40.10.1-0.3-0.20.1-0.4-0.40.0
Condit. Reinf. active responses1.01.22.50.3-0.5-1.41.00.1-1.5-0.91.41.41.11.6-1.41.10.80.0
Condit. Reinf. inactive responses1.61.94.01.2-1.3-1.31.8-0.6-2.0-0.41.81.80.92.0-1.60.90.60.0
Incentive salience index mean1.82.14.9-1.00.9-2.2-0.11.5-1.0-2.01.41.41.81.4-1.41.91.70.0
Condit. Reinf. lever presses3.14.210.4-1.41.3-3.2-0.22.2-1.2-2.81.81.92.62.1-2.02.62.40.0
Condit. Reinf. active minus inactive responses0.70.92.0-0.80.80.9-1.20.11.00.4-1.4-1.4-0.9-1.21.3-0.8-0.60.0
Condit. Reinf. active-inactive response ratio1.71.83.7-1.31.21.0-1.90.51.70.2-1.9-1.9-1.1-1.71.8-0.8-0.60.0
Condit. Reinf. active responses0.00.00.1-0.20.2-0.0-0.10.2-0.2-0.2-0.1-0.10.10.10.00.10.20.0
Condit. Reinf. inactive responses0.91.12.30.6-0.5-1.21.2-0.0-1.3-0.61.41.41.11.4-1.50.90.80.0
Condit. Reinf. lever presses0.30.41.80.3-0.2-0.40.60.1-1.4-0.40.80.80.61.0-0.80.50.50.0
Condit. Reinf. lever reinforcers received0.10.10.2-0.30.3-0.3-0.10.3-0.4-0.40.10.10.30.3-0.20.20.40.0
Conditioned reinforcement - actives0.30.31.20.4-0.01.1-0.2-0.3-0.40.5-0.5-0.6-0.6-0.60.6-0.7-0.60.0
Conditioned reinforcement - inactives1.21.33.91.0-0.42.0-0.0-1.1-0.41.2-1.0-1.1-1.5-1.01.2-1.5-1.60.0
Conditioned locomotion0.10.10.4-0.60.4-0.0-0.40.4-0.5-0.6-0.2-0.20.1-0.20.10.10.40.0
Patch foraging indifference point 0 sec1.01.73.81.6-1.61.81.0-1.9-0.31.8-0.2-0.3-1.5-0.50.7-1.5-1.80.0
Patch foraging indifference point AUC1.31.53.4-0.80.81.2-1.4-0.11.10.5-1.8-1.8-1.4-1.71.8-1.1-1.00.0
Delay disc. indifference point, 0s delay0.30.30.9-0.41.00.5-0.90.40.6-0.3-0.8-0.8-0.3-0.70.70.20.10.0
Delay disc. indifference point, 16s delay2.32.36.62.0-1.62.60.8-2.1-0.41.9-0.8-1.0-1.9-0.81.2-1.5-1.90.0
Delay disc. indifference point, 2s delay1.41.63.7-0.81.01.4-1.50.31.50.6-1.9-1.9-1.1-1.71.6-0.9-0.50.0
Delay disc. indifference point, 24s delay0.60.61.80.6-0.61.30.1-0.80.10.9-0.8-0.9-1.0-0.70.7-0.9-1.00.0
Delay disc. indifference point, 4s delay1.81.94.5-0.91.51.2-1.80.31.30.2-2.1-2.1-1.2-2.01.8-0.8-0.80.0
Delay disc. indifference point, 8s delay0.30.30.90.2-0.10.9-0.2-0.40.20.5-0.6-0.6-0.7-0.60.6-0.4-0.60.0
Indifference point function ln k0.50.71.6-0.60.6-1.3-0.21.0-0.2-1.10.60.71.10.6-0.81.01.10.0
Indifference point function log k0.50.71.6-0.60.6-1.3-0.21.0-0.2-1.10.60.71.10.6-0.81.01.10.0
Patch foraging total patch changes 0 sec1.42.25.01.9-1.72.01.1-2.2-0.42.0-0.4-0.5-1.8-0.60.9-1.7-2.10.0
Patch foraging total patch changes 12 sec1.51.95.21.5-1.52.30.8-2.0-0.41.9-0.6-0.8-1.7-0.61.0-1.6-1.80.0
Patch foraging total patch changes 18 sec2.43.17.52.7-2.42.02.0-2.7-1.72.30.30.1-1.60.20.3-1.7-1.80.0
Patch foraging total patch changes 24 sec2.73.38.42.9-2.81.92.6-2.6-2.22.01.31.1-0.80.9-0.6-1.2-1.30.0
Patch foraging total patch changes 6 sec1.92.86.52.2-2.02.51.4-2.5-0.82.2-0.2-0.4-1.9-0.40.8-1.8-2.20.0
Patch foraging time to switch 0 sec0.60.92.61.4-1.60.71.6-1.2-0.51.10.80.8-0.10.8-0.6-0.3-0.60.0
Patch foraging water rate 0 sec0.30.40.90.3-0.00.9-0.4-0.40.10.6-0.8-0.8-0.9-0.90.9-0.9-0.60.0
Patch foraging water rate 12 sec0.30.41.21.1-0.90.31.0-1.0-0.80.70.50.5-0.40.2-0.2-0.6-0.50.0
Patch foraging water rate 18 sec0.10.20.4-0.20.60.0-0.50.00.1-0.2-0.4-0.5-0.4-0.70.6-0.3-0.70.0
Patch foraging water rate 24 sec1.11.52.90.00.11.1-0.7-0.70.61.2-1.6-1.6-1.6-1.61.7-1.7-1.40.0
Patch foraging water rate 6 sec0.30.41.11.0-0.80.60.7-0.9-0.80.90.10.1-0.6-0.10.1-0.8-0.60.0
Seeking ratio, delayed vs. immediate footshock0.30.40.8-0.30.50.3-0.6-0.10.80.3-0.8-0.8-0.6-0.90.8-0.6-0.70.0
Distance traveled before self-admin0.40.51.2-1.11.1-1.1-0.71.00.0-1.0-0.1-0.00.60.1-0.10.70.70.0
Distance traveled after self-admin0.60.72.3-1.41.3-0.8-1.00.81.5-0.6-0.6-0.60.1-0.50.40.20.20.0
Extensor digitorum longus weight0.20.62.0-1.41.2-0.6-1.31.30.5-0.9-0.5-0.40.5-0.40.20.40.70.0
Bone: elastic displacement0.40.51.10.8-0.90.60.6-1.10.21.0-0.3-0.3-0.8-0.50.3-0.9-0.90.0
Bone: elastic work1.41.83.20.1-0.21.7-0.6-0.91.31.4-1.6-1.6-1.7-1.81.7-1.6-1.70.0
Bone: endosteal estimation3.27.018.7-4.04.3-0.9-4.33.33.2-1.9-2.9-2.70.2-2.51.90.50.60.0
Bone: endosteal perimeter2.45.013.3-3.53.7-2.1-3.03.61.5-2.8-0.9-0.71.7-0.50.11.92.10.0
Epididymis fat weight6.414.934.04.9-5.15.33.3-5.8-0.35.5-1.1-1.4-4.4-1.12.0-4.5-4.70.0
Delta time in closed arm before/after self-admin0.10.10.4-0.40.20.5-0.30.00.60.0-0.6-0.6-0.3-0.40.4-0.10.10.0
Delta time in open arm before/after self-admin0.00.00.30.2-0.10.10.2-0.30.20.30.0-0.0-0.3-0.10.1-0.2-0.50.0
Diff in mean of infusions in LGA sessions2.32.66.81.6-1.0-0.51.9-0.2-2.6-0.52.22.11.52.1-2.21.31.30.0
Delay discount exponential model param1.41.54.1-0.5-0.0-2.00.50.8-0.5-1.21.61.71.51.5-1.51.21.30.0
Extinction: sum of active levers before priming0.40.41.10.7-0.40.10.8-0.3-1.0-0.20.90.90.51.0-0.80.40.50.0
Active lever presses in extinction session 60.40.40.91.0-0.90.40.8-0.8-0.70.90.40.3-0.30.4-0.2-0.4-0.50.0
Bone: final force4.47.112.30.3-0.33.4-1.3-1.92.42.8-3.0-3.1-3.5-3.23.5-3.4-3.40.0
Bone: final moment4.06.411.00.2-0.23.1-1.3-1.72.42.6-2.9-3.0-3.3-3.13.3-3.2-3.30.0
Food consumed during 24 hour testing period0.81.02.4-1.51.5-0.8-1.61.01.0-0.7-1.1-1.1-0.2-1.00.90.0-0.10.0
Glucose4.36.515.1-3.53.4-3.1-2.43.91.1-3.70.20.52.70.6-1.13.03.30.0
Heart weight0.10.20.6-0.30.40.6-0.60.30.8-0.1-0.6-0.5-0.2-0.40.40.10.30.0
Delay discount hyperbolic model param1.41.43.6-0.2-0.3-1.90.80.6-0.7-1.11.71.71.41.5-1.61.21.10.0
Intermittent access intake day 1-15 change0.50.51.20.2-0.10.3-0.4-0.4-0.00.4-1.0-1.1-0.9-1.10.9-0.9-0.90.0
Intermittent access intake escalation0.30.30.7-0.50.7-0.5-0.80.50.3-0.3-0.8-0.8-0.2-0.80.5-0.2-0.20.0
Intermittent access intake escalation 21.71.74.9-1.92.2-1.9-1.72.00.5-1.7-0.5-0.40.9-0.4-0.01.01.00.0
Intermitt. access day 1 inactive lever presses0.40.41.4-0.81.20.3-1.11.00.6-0.6-0.6-0.60.2-0.30.40.00.50.0
Intermitt. access day 15 inactive lever presses1.51.73.4-0.50.21.6-1.1-0.51.10.8-1.6-1.7-1.6-1.51.8-1.9-1.40.0
Intermitt. access escalation Index1.91.73.50.6-0.3-1.01.10.5-1.3-0.61.81.81.71.8-1.91.31.40.0
Intermittent access day 1 total infusions0.30.41.30.1-0.6-0.10.8-0.3-1.1-0.40.80.80.40.7-0.80.40.20.0
Intermittent access day 15 total infusions0.10.11.00.2-0.6-0.00.4-0.3-1.0-0.20.20.1-0.00.0-0.2-0.1-0.10.0
Intermittent access terminal intake (last 3 days)0.10.10.30.1-0.30.50.1-0.4-0.60.1-0.3-0.3-0.4-0.30.2-0.3-0.40.0
Intermittent access total infusions0.10.10.90.2-0.40.30.4-0.4-1.00.00.20.1-0.20.0-0.1-0.2-0.20.0
Intermittent access day 1 locomotion0.30.31.1-1.00.5-0.8-0.20.6-0.2-1.00.20.30.70.2-0.50.70.40.0
Intermittent access day 15 total locomotion0.90.92.3-1.51.4-0.6-1.50.80.8-0.8-1.1-1.1-0.3-1.30.9-0.0-0.20.0
Intermittent access total locomotion0.70.82.7-1.61.3-0.8-1.20.70.6-0.8-1.0-0.9-0.2-1.10.70.0-0.20.0
Intermittent access standard deviation1.92.03.90.4-0.71.6-0.4-1.20.61.5-1.8-1.8-2.0-1.71.8-1.8-1.70.0
Left kidney weight2.77.514.0-1.01.32.3-2.4-0.63.72.0-3.7-3.7-3.1-3.73.6-2.8-2.90.0
Right kidney weight2.36.313.3-2.12.30.9-3.10.43.60.8-3.6-3.5-2.3-3.53.3-1.8-2.00.0
Cocaine induced anxiety2.52.97.7-1.11.0-2.8-0.11.8-0.9-2.11.71.82.21.5-1.82.12.00.0
Post-drug Anxiety1.01.12.2-0.70.5-1.5-0.21.2-0.6-1.21.01.11.41.1-1.01.21.50.0
Baseline Anxiety0.60.72.71.3-1.11.70.7-1.0-0.61.0-0.1-0.2-0.60.20.2-0.8-0.20.0
Tail length3.811.527.6-4.44.50.1-5.32.64.7-0.9-4.5-4.3-1.6-4.43.8-1.0-1.00.0
Length with tail3.312.128.2-3.84.00.7-4.91.75.3-0.1-4.8-4.7-2.3-4.74.2-1.8-1.90.0
Length without tail2.35.012.0-1.92.01.2-2.70.53.50.5-3.2-3.2-1.9-3.02.8-1.7-1.60.0
Times rat made contact with spout1.61.94.72.0-2.0-0.12.2-1.5-2.10.71.61.50.11.5-1.1-0.1-0.50.0
Lifetime Intake0.10.10.80.1-0.30.30.3-0.3-0.9-0.10.20.1-0.10.0-0.0-0.2-0.10.0
Liver weight, left1.01.64.6-2.11.8-1.1-1.91.42.1-1.2-1.1-1.00.2-1.00.80.40.10.0
Liver weight, right3.55.814.2-3.63.3-0.7-3.82.33.6-1.0-3.0-2.8-0.5-2.72.2-0.4-0.10.0
Locomotor activity2.23.510.1-3.23.2-1.4-2.82.22.3-1.6-1.7-1.50.2-1.51.10.30.50.0
Locomotor testing distance0.40.72.2-1.51.5-0.7-1.21.11.2-0.7-0.7-0.60.3-0.50.40.20.40.0
Locomotor testing rearing0.71.23.4-1.81.9-0.6-1.61.21.4-0.7-1.1-1.00.0-1.00.8-0.00.00.0
Locomotion in novel chamber0.50.61.4-0.30.40.6-0.7-0.10.90.4-1.1-1.1-0.8-1.21.0-0.7-0.80.0
Locomotion in novel chamber post-restriction0.50.61.10.3-0.31.0-0.2-0.70.70.9-0.9-1.0-1.0-0.90.9-0.8-0.90.0
Fecal boli incidents, locomotor time 10.50.51.20.1-0.1-1.00.70.2-0.4-0.31.01.10.91.0-1.00.50.80.0
Change in fecal boli incidents, locomotor task0.60.51.3-0.50.41.2-0.80.21.10.3-1.2-1.1-0.5-0.80.8-0.50.00.0
Time >=10cm from walls, locomotor time 10.80.82.8-1.51.7-0.4-1.51.21.0-0.5-0.8-0.80.1-0.60.60.00.40.0
Bouts of movement, locomotor time 11.31.43.5-0.80.8-1.9-0.01.2-0.8-1.71.11.11.41.0-1.21.71.20.0
Total resting periods, locomotor time 11.01.02.7-1.01.0-1.7-0.41.2-0.1-1.60.60.71.20.5-0.81.61.00.0
Rest time, locomotor task time 11.11.23.1-1.71.8-1.7-1.31.51.2-1.4-0.3-0.10.8-0.3-0.00.80.80.0
Distance moved, locomotor task time 10.70.82.10.8-0.71.50.2-1.00.21.3-0.6-0.6-1.1-0.60.9-1.1-1.10.0
Vertical activity count, locomotor time 10.60.61.91.0-0.91.20.3-0.9-0.11.4-0.3-0.4-0.9-0.30.6-1.1-0.80.0
Time >=10cm from walls, locomotor time 20.30.30.9-0.90.8-0.2-0.80.90.9-0.3-0.4-0.30.4-0.10.10.20.60.0
Bouts of movement, locomotor time 21.41.54.0-2.02.0-1.1-1.81.51.6-0.7-1.2-1.10.2-1.30.70.20.10.0
Total resting periods, locomotor time 21.81.95.3-2.32.3-1.5-2.01.91.5-1.2-1.0-0.90.6-1.10.40.70.60.0
Rest time, locomotor task time 22.83.27.4-2.72.6-2.7-1.92.71.1-2.3-0.20.01.7-0.0-0.51.81.80.0
Distance moved, locomotor task time 21.51.74.51.7-1.62.10.9-1.9-0.21.9-0.4-0.5-1.5-0.40.8-1.5-1.50.0
Vertical activity count, locomotor time 20.60.71.91.4-1.21.20.9-1.1-0.51.10.0-0.0-0.70.10.2-0.8-0.60.0
Light reinforcement 10.30.61.41.0-1.11.10.7-1.10.31.2-0.2-0.3-0.8-0.30.4-0.8-0.70.0
Light reinforcement 20.50.72.4-0.90.90.0-1.10.41.50.0-1.1-1.1-0.6-1.20.9-0.2-0.40.0
Bone: marrow area3.26.818.3-3.94.2-0.9-4.33.23.2-1.8-2.9-2.70.1-2.51.90.50.60.0
Bone: maximum diameter1.32.46.8-2.62.6-0.7-2.52.21.6-1.6-1.2-1.00.5-1.10.80.70.70.0
Bone: maximum force3.56.010.8-0.10.12.8-1.5-1.42.42.3-2.9-3.0-3.2-3.23.3-3.0-3.10.0
Bone: maximum moment3.25.49.9-0.20.32.5-1.6-1.22.42.0-2.9-2.9-3.0-3.13.1-2.8-2.90.0
Mean time between licks in bursts2.13.07.3-2.62.5-2.1-2.02.71.0-2.4-0.10.01.60.1-0.41.81.80.0
Mean num. licks in bursts1.21.43.91.9-1.80.61.7-2.0-0.71.50.50.3-1.00.2-0.0-1.1-1.60.0
Cd content in liver0.70.82.00.9-0.91.00.5-1.30.11.1-0.5-0.6-1.2-0.60.7-1.2-1.40.0
Co content in liver1.72.04.81.2-1.22.20.4-1.70.21.9-1.1-1.2-1.8-1.01.3-1.8-1.90.0
Cu content in liver2.83.48.22.4-2.4-0.32.9-1.5-2.60.62.42.30.82.3-2.00.40.40.0
Fe content in liver0.81.02.30.9-0.91.30.5-1.20.41.5-0.7-0.8-1.2-0.80.7-1.3-1.30.0
K content in liver0.20.20.50.1-0.1-0.10.20.1-0.7-0.50.50.50.40.7-0.40.50.70.0
Mg content in liver2.82.96.5-1.21.2-2.0-0.32.0-0.9-2.41.41.52.21.6-1.62.32.60.0
Mn content in liver4.34.910.9-2.82.8-2.7-1.83.30.4-3.30.50.72.50.8-1.22.63.00.0
Na content in liver0.10.10.40.5-0.50.60.3-0.6-0.10.50.20.1-0.5-0.10.3-0.4-0.30.0
Rb content in liver0.70.82.00.4-0.4-0.90.80.2-1.4-0.71.11.11.01.3-1.20.91.00.0
Se content in liver2.93.57.9-2.42.4-2.4-1.52.80.2-2.70.50.72.20.5-1.02.22.50.0
Sr content in liver0.70.71.8-1.21.20.0-1.30.91.3-0.4-0.8-0.7-0.1-0.80.70.00.10.0
Zn content in liver0.10.10.3-0.30.30.0-0.30.4-0.1-0.20.10.10.30.1-0.10.20.50.0
Bone: minimum diameter1.63.08.4-2.92.9-1.0-2.82.51.6-1.8-1.5-1.30.6-1.30.90.80.80.0
Time in familiar zone, hab. session 12.82.67.02.2-2.2-0.22.6-1.5-2.30.62.12.00.51.9-1.70.3-0.00.0
Time in novel zone, hab. session 11.91.84.7-1.91.9-0.0-2.21.51.9-0.7-1.6-1.5-0.1-1.51.20.10.40.0
Total zone transitions, hab. session 10.40.51.10.5-0.5-0.40.8-0.1-1.0-0.41.01.00.71.1-1.00.60.30.0
Total locomotion distance, hab. session 10.30.51.20.7-0.7-0.20.9-0.2-1.0-0.21.11.10.60.8-0.90.40.30.0
Locomotion velocity, hab. session 10.20.30.80.8-0.80.30.9-0.5-0.80.20.80.80.10.6-0.50.0-0.10.0
Time in familiar zone, hab. session 20.40.41.40.8-0.8-0.10.9-0.7-0.60.30.70.60.11.2-0.5-0.0-0.20.0
Time in novel zone, hab. session 20.30.31.4-0.40.40.3-0.60.10.90.1-0.8-0.8-0.4-1.20.6-0.3-0.30.0
Total zone transitions, hab. session 20.20.20.50.6-0.60.70.5-0.60.10.60.20.2-0.30.0-0.0-0.3-0.50.0
Total locomotion distance, hab. session 20.60.82.00.9-0.9-0.31.3-0.3-1.0-0.21.41.40.80.9-1.20.60.50.0
Locomotion velocity, hab. session 20.70.92.30.8-0.9-0.31.2-0.2-1.1-0.31.51.50.91.1-1.30.80.60.0
Novel to familiar place preference ratio0.20.20.40.6-0.60.60.4-0.6-0.30.50.10.1-0.30.10.1-0.4-0.40.0
Novelty place preference0.10.10.50.3-0.30.70.1-0.4-0.00.5-0.1-0.2-0.4-0.20.3-0.5-0.40.0
Time in novel zone, NPP test0.10.10.50.2-0.20.7-0.1-0.30.20.5-0.3-0.3-0.5-0.40.5-0.5-0.50.0
Total zone transitions, NPP test0.60.92.10.5-0.5-0.91.00.1-1.0-0.71.41.41.11.0-1.41.00.60.0
Total locomotion distance, NPP test0.71.02.31.1-1.2-0.41.5-0.5-1.4-0.11.51.50.70.9-1.30.60.40.0
Locomotion velocity, NPP test1.21.84.11.4-1.4-0.61.9-0.6-1.9-0.32.02.01.01.4-1.70.80.60.0
Intraocular pressure0.60.82.10.4-0.3-1.41.0-0.0-0.9-0.51.41.30.91.1-1.20.80.40.0
Delta distance traveled before/after self-admin0.90.93.4-0.50.30.7-0.7-0.31.90.6-1.2-1.2-1.0-1.21.2-1.0-1.00.0
Delta ambulatory time before/after self-admin0.50.63.2-0.90.70.0-0.80.31.8-0.0-0.9-0.9-0.4-0.90.7-0.4-0.30.0
Parametrial fat weight1.63.15.50.00.01.8-0.9-1.11.81.9-2.2-2.2-2.3-2.22.3-2.3-2.20.0
Pavlov. Cond. lever latency2.63.27.02.2-2.12.61.3-2.50.02.6-0.8-1.0-2.0-1.11.0-2.2-2.20.0
Pavlov. Cond. magazine entry latency2.53.27.8-2.12.0-2.8-1.12.50.1-2.60.80.92.10.8-1.22.22.10.0
Pavlov. Cond. change in total contacts1.21.33.9-2.01.9-1.1-1.81.61.1-1.3-0.7-0.60.3-0.60.60.50.50.0
Pavlov. Cond. index score3.24.19.4-2.52.3-3.1-1.42.9-0.0-2.90.91.02.30.9-1.22.52.50.0
Pavlov. Cond. latency score2.83.67.8-2.52.4-2.8-1.62.80.2-2.80.70.82.00.8-0.92.22.20.0
Pavlov. Cond. lever contacts2.22.65.7-2.32.2-2.3-1.62.40.4-2.30.40.51.60.6-0.51.81.80.0
Pavlov. Cond. magazine entry number2.32.87.21.5-1.42.70.5-2.10.62.4-1.1-1.3-2.2-1.21.5-2.2-2.10.0
Pavlov. Cond. intertrial magazine entries1.11.44.11.9-2.00.81.9-1.7-1.41.00.70.6-0.40.7-0.5-0.4-0.70.0
Pavlov. Cond. lever-magazine prob. diff.3.34.19.8-2.32.2-3.1-1.32.8-0.1-2.91.01.12.41.0-1.32.52.50.0
Pavlov. Cond. response bias3.13.89.4-2.12.0-3.1-1.12.6-0.2-2.81.01.22.41.1-1.42.52.40.0
Pavlov. Cond. lever latency0.20.20.7-0.50.40.3-0.70.30.8-0.0-0.7-0.7-0.3-0.80.6-0.1-0.10.0
Pavlov. Cond. magazine entry latency0.30.40.9-0.70.80.2-1.00.30.70.1-0.7-0.7-0.5-0.60.8-0.5-0.40.0
Pavlov. Cond. change in total contacts0.20.30.80.4-0.30.70.2-0.8-0.20.8-0.2-0.3-0.8-0.20.5-0.9-0.90.0
Pavlov. Cond. index score0.00.00.1-0.00.1-0.1-0.0-0.1-0.30.10.10.0-0.10.20.1-0.2-0.20.0
Pavlov. Cond. latency score0.00.10.20.00.00.2-0.1-0.2-0.20.3-0.1-0.2-0.3-0.00.3-0.5-0.40.0
Pavlov. Cond. lever contacts0.30.51.01.0-0.90.21.0-1.0-0.90.70.60.5-0.30.6-0.3-0.5-0.60.0
Pavlov. Cond. magazine entry number0.20.20.50.2-0.2-0.30.40.2-0.3-0.50.40.50.60.5-0.70.70.70.0
Pavlov. Cond. intertrial magazine entries1.72.24.8-1.31.3-2.1-0.51.9-0.3-2.20.91.02.00.9-1.42.12.10.0
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.00.1-0.1-0.0-0.1-0.30.10.10.0-0.10.20.1-0.2-0.30.0
Pavlov. Cond. response bias0.10.10.30.3-0.2-0.30.5-0.3-0.50.20.60.50.00.5-0.3-0.1-0.20.0
Time in closed arm before self-admin0.00.00.10.4-0.20.30.2-0.1-0.20.20.20.20.00.2-0.1-0.2-0.00.0
Time in closed arm after self-admin0.80.82.50.6-0.81.60.1-1.00.51.0-0.8-0.8-1.1-0.60.9-1.1-0.90.0
Time in open arm before self-admin0.60.72.2-0.91.0-1.5-0.51.10.1-1.10.40.50.90.2-0.51.10.70.0
Time in open arm after self-admin0.70.82.4-0.70.8-1.5-0.00.9-0.3-0.91.01.01.10.7-1.01.20.80.0
Bone: periosteal estimation2.34.711.4-2.82.80.5-3.41.72.8-0.5-2.9-2.8-1.0-2.82.4-0.7-0.60.0
Bone: periosteal perimeter1.42.36.3-2.42.4-0.2-2.51.71.8-1.0-1.7-1.6-0.1-1.61.30.10.10.0
Bone: post-yield work1.11.43.4-1.81.8-1.6-1.41.80.6-1.7-0.3-0.21.0-0.2-0.21.21.00.0
Progressive ratio test 1 active lever presses0.10.10.60.3-0.30.50.4-0.1-0.8-0.10.40.30.30.3-0.40.30.10.0
Progressive ratio test 1 breakpoint0.20.20.70.4-0.40.70.5-0.2-0.9-0.00.40.40.20.3-0.40.20.10.0
Progressive ratio test 1 inactive lever presses0.60.61.91.2-1.21.10.9-1.1-1.40.30.30.2-0.50.4-0.1-0.6-0.50.0
Progressive ratio test 2 active lever presses0.50.62.80.8-0.7-0.11.0-0.4-1.7-0.30.90.90.40.7-0.90.40.30.0
Progressive ratio test 2 breakpoint0.91.04.71.0-1.0-0.31.3-0.5-2.2-0.31.31.20.61.0-1.20.50.40.0
Progressive ratio test 2 inactive lever presses0.20.20.4-0.60.50.5-0.60.10.0-0.2-0.5-0.5-0.4-0.60.6-0.5-0.50.0
Incentive Sensitization - Responses0.40.51.90.7-0.6-0.30.8-0.2-1.4-0.30.80.80.50.7-0.90.40.50.0
Incentive Sensitization - Breakpoint0.50.62.00.6-0.5-0.50.8-0.1-1.4-0.41.00.90.60.8-1.00.50.60.0
Sum of active levers in priming session hrs 5-60.30.30.60.5-0.4-0.10.6-0.0-0.8-0.30.60.60.60.7-0.70.40.70.0
Progressive ratio3.43.97.5-0.20.41.9-1.2-1.02.11.8-2.7-2.7-2.5-2.62.6-2.5-2.10.0
Food seeking constrained by brief footshock0.00.00.2-0.1-0.5-0.30.1-0.00.00.20.10.10.10.1-0.10.10.00.0
Seeking ratio, punishment vs. effort2.93.56.80.2-0.6-1.71.20.9-2.0-1.52.62.62.32.6-2.52.32.00.0
Retroperitoneal fat weight0.30.91.70.00.21.1-0.5-0.61.31.0-1.2-1.2-1.2-1.21.2-1.0-1.10.0
Reaction time number correct0.91.33.31.8-1.61.41.2-1.7-0.81.60.1-0.1-1.1-0.00.3-1.2-1.10.0
Reaction time mean minus median3.64.712.4-3.43.3-3.5-2.43.11.6-2.8-0.2-0.01.8-0.3-0.42.01.60.0
Reaction time mean minus median AUC2.43.18.7-2.62.5-2.9-1.82.61.0-2.30.00.21.70.0-0.61.71.60.0
Reaction time num false alarms0.30.40.9-0.60.60.4-0.90.30.90.0-1.0-0.9-0.5-0.90.8-0.3-0.20.0
Reaction time num false alarms AUC0.50.61.5-0.70.70.6-1.10.31.10.1-1.2-1.2-0.6-1.11.0-0.4-0.20.0
Reaction time trials correct on left0.91.33.31.8-1.61.41.2-1.7-0.81.60.1-0.1-1.1-0.00.3-1.2-1.10.0
Reaction time trials on left0.81.12.91.7-1.51.41.1-1.6-0.71.50.0-0.1-1.0-0.10.3-1.2-1.00.0
Reaction time mean3.14.410.9-3.02.9-3.3-1.93.01.0-3.00.20.42.10.3-0.82.32.00.0
Reaction time mean AUC3.34.411.4-3.12.9-3.4-1.93.01.1-2.90.20.42.10.2-0.82.32.00.0
Median of all reaction times2.02.76.4-2.32.1-2.5-1.42.40.6-2.40.30.51.70.4-0.82.01.70.0
Reaction time omissions2.22.96.5-2.52.4-2.5-1.72.60.8-2.40.10.31.70.1-0.61.91.70.0
Reaction time false alarm rate0.71.02.6-1.61.5-0.2-1.61.21.3-0.9-1.1-1.00.1-0.90.70.40.50.0
Reaction time premature initiation rate1.01.32.50.0-0.01.6-0.7-0.61.21.3-1.4-1.4-1.4-1.51.5-1.5-1.10.0
Reaction time premature initiations1.72.45.80.9-0.82.4-0.1-1.50.82.2-1.4-1.5-2.0-1.51.7-2.2-1.70.0
Std. dev. reaction times3.65.013.0-3.63.5-3.3-2.63.31.8-2.9-0.4-0.21.8-0.4-0.32.01.70.0
Reaction time trials completed0.81.12.91.7-1.51.41.1-1.6-0.71.50.0-0.1-1.0-0.10.3-1.2-1.00.0
Reaction time trials AUC0.81.12.91.7-1.51.31.1-1.6-0.71.50.1-0.0-1.00.00.3-1.2-1.00.0
Run reversals in cocaine runway, females0.70.61.91.3-1.01.00.9-1.4-0.30.90.30.2-0.80.10.3-0.5-1.00.0
Run reversals in cocaine runway, males2.42.37.7-2.52.8-1.7-2.11.92.1-1.1-1.0-0.80.4-1.10.70.30.50.0
Latency to leave start box in cocaine runway0.10.10.70.10.20.8-0.1-0.00.50.7-0.2-0.2-0.2-0.20.2-0.50.00.0
Latency to leave start box in cocaine runway, F0.20.20.6-0.10.3-0.30.10.4-0.1-0.10.50.60.60.6-0.50.40.70.0
Latency to leave start box in cocaine runway, M1.41.43.30.6-0.41.8-0.2-1.01.01.6-1.1-1.2-1.4-1.11.3-1.6-1.40.0
Std. dev. time between licks in bursts2.12.56.6-2.52.4-1.4-2.12.61.1-2.1-0.5-0.31.3-0.0-0.01.51.80.0
Total sessions with >9 infusions0.10.10.4-0.20.10.6-0.1-0.1-0.6-0.4-0.1-0.1-0.2-0.20.2-0.1-0.10.0
Short access day 1 total inactive lever presses1.11.34.3-2.11.6-0.9-1.61.70.5-1.8-0.6-0.50.7-0.40.20.60.90.0
Short access day 10 total inactive lever presses0.20.20.8-0.60.9-0.5-0.70.80.1-0.8-0.2-0.20.40.00.00.10.50.0
Short access day 1 total infusions0.20.30.6-0.1-0.0-0.00.30.3-0.8-0.60.60.60.60.5-0.60.70.80.0
Short access day 10 total infusions0.10.10.2-0.3-0.10.5-0.1-0.2-0.4-0.1-0.0-0.0-0.3-0.20.3-0.3-0.20.0
Short access total infusions0.10.10.5-0.1-0.10.7-0.1-0.1-0.4-0.1-0.1-0.1-0.2-0.20.3-0.2-0.10.0
Short access day 1 locomotion2.32.54.30.1-0.5-1.41.10.7-2.0-1.62.02.11.92.0-2.11.81.90.0
Short access day 10 total locomotion0.80.92.8-1.71.4-0.7-1.41.60.6-1.0-0.4-0.30.7-0.30.10.81.20.0
Short access total locomotion0.30.30.9-0.80.4-0.3-0.30.8-0.4-0.90.40.50.70.4-0.40.80.90.0
One hour access (0.3 mA shock)0.50.62.1-0.0-0.0-0.70.50.3-1.5-0.71.01.00.80.9-0.90.70.50.0
Compulsive drug intake2.12.13.90.4-0.1-1.10.90.9-1.2-1.01.92.02.02.0-2.01.71.90.0
One hour access (shock baseline)0.40.40.9-1.00.8-0.2-0.80.10.2-0.1-0.7-0.7-0.6-0.90.8-0.6-0.80.0
Social response proportion0.40.41.2-1.01.1-0.3-0.90.91.1-0.4-0.5-0.40.3-0.30.20.50.50.0
Social responses0.20.21.2-0.40.40.6-0.50.21.10.3-0.7-0.6-0.2-0.40.4-0.10.10.0
Social time2.22.97.8-2.82.6-1.7-2.32.71.7-2.0-0.7-0.51.3-0.50.11.51.60.0
Soleus weight1.95.716.4-4.13.8-1.7-3.53.71.8-3.0-1.4-1.11.4-1.10.51.62.00.0
Bone: stiffness1.01.63.70.6-0.51.7-0.2-1.20.71.5-1.2-1.3-1.7-1.31.5-1.7-1.90.0
Tibialis anterior weight0.41.33.61.7-1.91.41.3-1.7-1.11.40.20.1-0.90.20.1-1.1-1.10.0
Time to tail flick, vehicle, before self-admin0.30.30.9-0.60.7-0.9-0.30.6-0.1-0.90.10.10.60.2-0.30.60.50.0
Time to tail flick, vehicle, after self-admin1.41.53.0-1.11.6-1.7-0.61.6-0.7-1.70.60.61.50.8-0.91.31.60.0
Time to tail flick, test, before self-admin0.30.31.11.0-0.80.70.3-0.6-0.30.8-0.1-0.1-0.5-0.20.2-0.5-0.50.0
Time to tail flick, test, after self-admin1.31.35.3-0.91.0-2.3-0.21.2-0.3-1.80.80.91.30.6-1.11.41.10.0
Delta time to tail flick, vehicle, before/after SA0.40.40.80.10.1-0.80.40.4-0.7-0.40.90.90.80.8-0.90.70.80.0
Delta time to tail flick, test, before/after SA0.80.72.3-0.30.2-1.50.50.4-0.6-1.11.01.00.90.9-1.10.90.70.0
Tibia length2.36.415.8-3.33.40.1-3.82.04.0-0.7-3.3-3.1-1.0-3.12.6-0.6-0.40.0
Ambulatory time before self-admin0.10.10.3-0.30.5-0.3-0.30.3-0.2-0.6-0.0-0.10.10.00.10.30.20.0
Ambulatory time after self-admin0.50.51.9-1.21.4-0.9-0.90.81.3-0.4-0.4-0.40.2-0.40.30.20.30.0
Bone: tissue strength3.03.05.10.2-0.12.0-0.9-1.11.91.8-2.0-2.0-2.2-2.12.3-2.1-2.00.0
Total heroin consumption0.00.00.20.00.1-0.1-0.00.1-0.4-0.20.10.10.10.2-0.10.20.10.0
Bone: trabecular number1.32.05.11.7-1.7-0.32.1-1.1-2.30.21.91.90.61.6-1.50.40.10.0
Bone: trabecular spacing2.53.38.2-1.51.61.2-2.40.52.90.6-2.6-2.5-1.5-2.32.4-1.4-1.00.0
Bone: trabecular thickness0.91.02.91.1-1.2-0.61.5-0.6-1.7-0.01.41.30.61.2-1.20.40.10.0
Bone: trabecular tissue density1.21.73.2-0.10.21.7-1.0-0.51.51.2-1.6-1.6-1.6-1.71.8-1.5-1.40.0
Water consumed over 24 hours0.10.10.3-0.50.5-0.2-0.40.5-0.2-0.5-0.1-0.10.30.1-0.00.30.50.0
Number of responses in last shaping day0.20.20.5-0.60.40.7-0.70.40.3-0.5-0.6-0.6-0.1-0.50.5-0.10.20.0