Prr15l

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Prr15l 0.03 0.03 4.9e-03 0.02 0.01 0.01 0.01 1.1e-02 5.4e-02 5.5e-02 7.2e-02
2 Liver gene expression Prr15l 0.04 0.03 4.8e-07 0.05 0.05 0.04 0.05 3.4e-06 3.3e-06 3.2e-05 3.0e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density1.62.62.7-1.61.7
Area under the delay curve0.30.40.50.7-0.5
BMI with tail14.045.348.5-7.06.5
BMI without tail1.32.62.7-1.61.6
Body weight0.62.42.9-1.71.4
Weight adjusted by age1.11.21.41.2-1.0
Bone surface0.30.60.7-0.70.9
Bone volume1.22.02.3-1.31.5
Breakpoint value in progressive ratio session4.14.54.52.1-2.1
Number of licking bursts0.10.10.10.4-0.4
Context. condit. distance diff. score0.30.30.5-0.70.4
Locomotion velocity, session 10.40.40.5-0.60.7
Locomotion distance, session 12.63.33.81.9-1.7
Locomotion velocity, session 21.21.41.91.4-1.0
Locomotion distance, session 23.04.24.62.1-1.9
Locomotion velocity, session 30.00.00.00.1-0.1
Locomotion distance, session 33.23.53.61.8-1.9
Stereotopy head waving bouts, day 35.16.06.5-2.62.4
Stereotopy head waving duration, day 33.84.54.7-2.22.1
Locomotion velocity, session 71.21.31.41.1-1.2
Locomotion distance, session 74.96.26.52.4-2.6
Stereotopy head waving bouts, day 70.50.60.7-0.60.9
Stereotopy head waving duration, day 70.20.30.4-0.40.6
Locomotion velocity, session 80.20.30.5-0.70.3
Locomotion distance, session 80.60.90.91.0-1.0
Degree of sensitization distance0.00.00.0-0.20.0
Degree of sensitization stereotypy0.10.10.20.5-0.2
Conditioned locomotion1.21.51.7-1.31.1
Cocaine response after cond. corrected5.86.56.8-2.62.5
Cocaine response after cond. not corrected3.13.53.6-1.91.8
Cocaine response before conditioning2.42.93.11.8-1.7
Saline control response0.00.00.10.2-0.3
Bone: connectivity density0.10.20.2-0.40.4
Bone: cortical apparent density6.18.09.22.6-3.0
Bone: cortical area0.00.10.10.20.3
Bone: cortical porosity0.30.30.5-0.40.7
Bone: cortical porosity0.20.30.4-0.30.6
Bone: cortical thickness0.20.30.40.6-0.6
Bone: cortical thickness1.21.31.41.2-1.1
Bone: cortical tissue density6.58.59.72.7-3.1
Condit. Reinf. active minus inactive responses0.20.20.40.6-0.3
Condit. Reinf. active-inactive response ratio0.10.10.3-0.10.5
Condit. Reinf. active responses0.20.20.30.5-0.3
Condit. Reinf. inactive responses0.40.50.50.7-0.7
Incentive salience index mean0.60.71.11.1-0.6
Condit. Reinf. lever presses1.21.72.21.5-1.1
Condit. Reinf. active minus inactive responses0.10.10.2-0.10.4
Condit. Reinf. active-inactive response ratio0.40.40.4-0.60.7
Condit. Reinf. active responses0.00.00.10.30.0
Condit. Reinf. inactive responses0.30.30.40.6-0.5
Condit. Reinf. lever presses0.91.31.41.2-1.1
Condit. Reinf. lever reinforcers received0.10.10.20.4-0.2
Conditioned reinforcement - actives0.70.71.0-0.71.0
Conditioned reinforcement - inactives0.50.50.80.9-0.4
Conditioned locomotion3.03.64.9-1.62.2
Patch foraging indifference point 0 sec0.50.91.5-0.51.2
Patch foraging indifference point AUC0.10.10.10.3-0.4
Delay disc. indifference point, 0s delay0.80.91.00.9-1.0
Delay disc. indifference point, 16s delay0.30.30.3-0.60.6
Delay disc. indifference point, 2s delay0.20.20.30.5-0.3
Delay disc. indifference point, 24s delay0.80.71.01.0-0.7
Delay disc. indifference point, 4s delay3.63.84.12.0-1.9
Delay disc. indifference point, 8s delay0.20.20.30.6-0.4
Indifference point function ln k0.20.20.40.6-0.2
Indifference point function log k0.20.20.40.6-0.2
Patch foraging total patch changes 0 sec0.60.91.5-0.61.2
Patch foraging total patch changes 12 sec0.10.10.2-0.10.4
Patch foraging total patch changes 18 sec1.31.72.0-1.21.4
Patch foraging total patch changes 24 sec1.31.62.6-0.81.6
Patch foraging total patch changes 6 sec0.40.71.0-0.61.0
Patch foraging time to switch 0 sec0.00.10.1-0.20.3
Patch foraging water rate 0 sec0.71.11.2-1.01.1
Patch foraging water rate 12 sec0.10.10.20.4-0.3
Patch foraging water rate 18 sec0.50.60.80.9-0.6
Patch foraging water rate 24 sec0.60.90.9-0.90.9
Patch foraging water rate 6 sec0.00.00.00.00.0
Seeking ratio, delayed vs. immediate footshock0.40.40.6-0.80.5
Distance traveled before self-admin0.60.60.70.8-0.7
Distance traveled after self-admin0.60.60.8-0.70.9
Extensor digitorum longus weight0.00.10.2-0.40.4
Bone: elastic displacement0.20.20.2-0.40.4
Bone: elastic work0.00.00.00.1-0.0
Bone: endosteal estimation0.20.40.7-0.20.8
Bone: endosteal perimeter0.30.71.2-0.51.1
Epididymis fat weight0.00.00.00.0-0.0
Delta time in closed arm before/after self-admin0.20.20.30.5-0.4
Delta time in open arm before/after self-admin0.10.10.10.3-0.4
Diff in mean of infusions in LGA sessions0.50.50.60.7-0.8
Delay discount exponential model param0.50.50.7-0.80.6
Extinction: sum of active levers before priming1.61.61.91.4-1.2
Active lever presses in extinction session 60.20.20.2-0.40.4
Bone: final force0.10.20.3-0.10.6
Bone: final moment0.20.30.4-0.30.7
Food consumed during 24 hour testing period1.92.42.81.7-1.4
Glucose0.71.11.6-1.20.8
Heart weight1.92.72.8-1.71.6
Delay discount hyperbolic model param0.70.81.0-1.00.8
Intermittent access intake day 1-15 change3.03.03.1-1.71.8
Intermittent access intake escalation3.02.93.0-1.71.7
Intermittent access intake escalation 22.82.83.3-1.81.5
Intermitt. access day 1 inactive lever presses0.10.10.10.1-0.4
Intermitt. access day 15 inactive lever presses0.60.70.8-0.90.7
Intermitt. access escalation Index1.31.21.6-0.91.3
Intermittent access day 1 total infusions0.70.90.91.0-0.9
Intermittent access day 15 total infusions0.10.10.1-0.20.3
Intermittent access terminal intake (last 3 days)0.10.10.2-0.40.4
Intermittent access total infusions0.00.00.10.3-0.1
Intermittent access day 1 locomotion0.40.40.60.7-0.5
Intermittent access day 15 total locomotion0.20.30.4-0.40.6
Intermittent access total locomotion0.40.40.6-0.50.8
Intermittent access standard deviation3.13.33.5-1.91.8
Left kidney weight0.00.00.00.2-0.2
Right kidney weight0.20.60.7-0.70.8
Cocaine induced anxiety0.10.10.1-0.40.4
Post-drug Anxiety0.30.30.40.5-0.6
Baseline Anxiety0.00.00.0-0.2-0.1
Tail length12.738.642.16.5-5.9
Length with tail7.527.428.35.3-5.1
Length without tail0.20.40.50.5-0.7
Times rat made contact with spout0.20.20.30.6-0.3
Lifetime Intake0.10.20.30.5-0.3
Liver weight, left0.71.21.21.1-1.1
Liver weight, right0.81.31.51.0-1.2
Locomotor activity0.40.61.0-0.41.0
Locomotor testing distance0.71.11.8-0.61.4
Locomotor testing rearing0.10.10.10.30.4
Locomotion in novel chamber0.70.81.00.8-1.0
Locomotion in novel chamber post-restriction1.21.41.6-1.11.3
Fecal boli incidents, locomotor time 14.04.45.1-2.31.9
Change in fecal boli incidents, locomotor task3.33.13.31.8-1.7
Time >=10cm from walls, locomotor time 10.40.40.50.7-0.5
Bouts of movement, locomotor time 10.10.10.2-0.40.2
Total resting periods, locomotor time 10.30.30.5-0.70.4
Rest time, locomotor task time 10.30.40.5-0.70.5
Distance moved, locomotor task time 11.21.41.41.2-1.2
Vertical activity count, locomotor time 10.60.70.80.9-0.7
Time >=10cm from walls, locomotor time 20.80.91.01.0-0.9
Bouts of movement, locomotor time 20.10.10.2-0.40.3
Total resting periods, locomotor time 20.20.20.2-0.50.3
Rest time, locomotor task time 20.91.11.21.0-1.1
Distance moved, locomotor task time 20.20.20.30.5-0.4
Vertical activity count, locomotor time 20.00.00.10.30.1
Light reinforcement 10.30.60.6-0.70.8
Light reinforcement 20.00.00.00.00.1
Bone: marrow area0.10.20.4-0.10.7
Bone: maximum diameter0.30.50.9-0.21.0
Bone: maximum force0.30.50.9-0.40.9
Bone: maximum moment0.30.60.9-0.51.0
Mean time between licks in bursts0.10.20.2-0.50.3
Mean num. licks in bursts0.00.00.10.2-0.1
Cd content in liver0.50.60.70.7-0.8
Co content in liver0.20.20.4-0.60.2
Cu content in liver2.42.93.41.8-1.6
Fe content in liver1.21.41.51.2-1.2
K content in liver0.20.20.2-0.50.5
Mg content in liver0.60.60.70.8-0.7
Mn content in liver2.42.82.81.7-1.7
Na content in liver0.90.91.2-0.81.1
Rb content in liver0.00.00.10.0-0.2
Se content in liver0.50.60.7-0.90.6
Sr content in liver2.32.12.51.6-1.3
Zn content in liver0.00.00.1-0.10.3
Bone: minimum diameter0.00.00.10.20.2
Time in familiar zone, hab. session 10.50.40.60.5-0.8
Time in novel zone, hab. session 13.43.33.3-1.81.8
Total zone transitions, hab. session 16.28.69.02.9-3.0
Total locomotion distance, hab. session 12.63.73.71.9-1.9
Locomotion velocity, hab. session 13.55.05.12.3-2.2
Time in familiar zone, hab. session 20.80.81.2-1.10.6
Time in novel zone, hab. session 20.10.10.20.5-0.3
Total zone transitions, hab. session 22.33.03.71.9-1.5
Total locomotion distance, hab. session 20.00.10.10.3-0.1
Locomotion velocity, hab. session 20.10.10.20.4-0.2
Novel to familiar place preference ratio1.01.01.10.9-1.1
Novelty place preference1.11.11.30.9-1.1
Time in novel zone, NPP test0.80.81.00.8-1.0
Total zone transitions, NPP test3.85.46.32.5-2.1
Total locomotion distance, NPP test0.91.21.51.2-0.9
Locomotion velocity, NPP test1.42.02.41.6-1.3
Intraocular pressure1.72.32.51.6-1.5
Delta distance traveled before/after self-admin1.51.61.7-1.31.3
Delta ambulatory time before/after self-admin2.02.22.2-1.51.5
Parametrial fat weight0.10.10.20.50.1
Pavlov. Cond. lever latency1.51.92.3-1.51.2
Pavlov. Cond. magazine entry latency0.10.10.20.4-0.1
Pavlov. Cond. change in total contacts2.62.83.21.8-1.6
Pavlov. Cond. index score0.70.91.21.1-0.7
Pavlov. Cond. latency score0.81.01.41.2-0.8
Pavlov. Cond. lever contacts2.42.83.51.9-1.5
Pavlov. Cond. magazine entry number0.40.40.7-0.80.4
Pavlov. Cond. intertrial magazine entries0.40.50.70.5-0.8
Pavlov. Cond. lever-magazine prob. diff.0.70.91.21.1-0.7
Pavlov. Cond. response bias0.81.01.31.1-0.8
Pavlov. Cond. lever latency1.01.31.81.3-1.0
Pavlov. Cond. magazine entry latency0.40.40.60.5-0.8
Pavlov. Cond. change in total contacts0.20.30.3-0.50.5
Pavlov. Cond. index score0.40.40.6-0.80.5
Pavlov. Cond. latency score0.20.20.3-0.60.3
Pavlov. Cond. lever contacts0.81.01.4-1.20.9
Pavlov. Cond. magazine entry number0.00.00.10.30.1
Pavlov. Cond. intertrial magazine entries1.82.32.41.5-1.5
Pavlov. Cond. lever-magazine prob. diff.0.40.50.7-0.80.6
Pavlov. Cond. response bias0.70.91.3-1.10.8
Time in closed arm before self-admin1.92.12.3-1.51.4
Time in closed arm after self-admin0.60.60.6-0.80.8
Time in open arm before self-admin1.01.01.41.2-0.8
Time in open arm after self-admin1.11.21.51.2-1.0
Bone: periosteal estimation0.20.40.8-0.20.9
Bone: periosteal perimeter0.30.50.8-0.40.9
Bone: post-yield work0.10.20.2-0.50.3
Progressive ratio test 1 active lever presses0.80.81.21.1-0.7
Progressive ratio test 1 breakpoint1.11.11.41.2-0.9
Progressive ratio test 1 inactive lever presses0.00.00.00.20.1
Progressive ratio test 2 active lever presses0.40.40.60.8-0.4
Progressive ratio test 2 breakpoint0.30.30.50.7-0.3
Progressive ratio test 2 inactive lever presses0.00.10.10.2-0.2
Incentive Sensitization - Responses0.00.00.10.00.3
Incentive Sensitization - Breakpoint0.10.10.3-0.20.5
Sum of active levers in priming session hrs 5-63.83.74.12.0-1.8
Progressive ratio0.00.00.1-0.3-0.0
Food seeking constrained by brief footshock0.70.90.9-0.91.0
Seeking ratio, punishment vs. effort0.10.10.10.40.1
Retroperitoneal fat weight0.41.41.6-1.31.1
Reaction time number correct0.00.00.00.0-0.2
Reaction time mean minus median1.11.51.71.3-1.1
Reaction time mean minus median AUC1.41.82.01.4-1.2
Reaction time num false alarms0.40.50.70.8-0.6
Reaction time num false alarms AUC0.50.60.80.9-0.6
Reaction time trials correct on left0.00.00.00.0-0.2
Reaction time trials on left0.00.00.10.1-0.2
Reaction time mean0.20.30.40.6-0.4
Reaction time mean AUC0.30.40.60.8-0.5
Median of all reaction times0.00.00.00.10.2
Reaction time omissions0.30.30.40.7-0.5
Reaction time false alarm rate0.20.20.40.6-0.3
Reaction time premature initiation rate0.50.70.80.9-0.8
Reaction time premature initiations0.81.11.21.1-1.0
Std. dev. reaction times0.81.11.31.2-0.9
Reaction time trials completed0.00.00.10.1-0.2
Reaction time trials AUC0.00.00.10.2-0.3
Run reversals in cocaine runway, females0.40.40.60.7-0.5
Run reversals in cocaine runway, males0.50.50.7-0.50.8
Latency to leave start box in cocaine runway3.74.04.8-2.21.8
Latency to leave start box in cocaine runway, F5.15.66.5-2.52.2
Latency to leave start box in cocaine runway, M1.11.11.4-1.20.9
Std. dev. time between licks in bursts1.11.31.5-1.11.2
Total sessions with >9 infusions0.10.10.2-0.00.4
Short access day 1 total inactive lever presses3.03.33.61.9-1.7
Short access day 10 total inactive lever presses0.20.20.40.3-0.6
Short access day 1 total infusions0.10.10.10.3-0.2
Short access day 10 total infusions0.20.20.2-0.40.5
Short access total infusions0.00.00.00.2-0.0
Short access day 1 locomotion1.11.21.2-1.11.1
Short access day 10 total locomotion0.70.71.0-0.71.0
Short access total locomotion1.21.31.4-1.11.2
One hour access (0.3 mA shock)0.91.11.31.2-0.9
Compulsive drug intake9.49.510.13.2-3.0
One hour access (shock baseline)2.83.33.3-1.81.8
Social response proportion0.70.70.70.8-0.8
Social responses0.00.00.00.1-0.1
Social time0.00.00.0-0.2-0.1
Soleus weight1.23.64.1-2.01.8
Bone: stiffness0.00.00.00.20.2
Tibialis anterior weight0.51.72.11.4-1.1
Time to tail flick, vehicle, before self-admin1.81.82.01.3-1.4
Time to tail flick, vehicle, after self-admin0.40.40.7-0.80.4
Time to tail flick, test, before self-admin0.20.20.2-0.40.4
Time to tail flick, test, after self-admin0.00.00.1-0.20.1
Delta time to tail flick, vehicle, before/after SA2.01.92.3-1.51.3
Delta time to tail flick, test, before/after SA0.30.30.30.5-0.6
Tibia length0.41.11.5-1.20.8
Ambulatory time before self-admin0.50.50.70.8-0.5
Ambulatory time after self-admin0.90.91.1-0.91.1
Bone: tissue strength0.10.10.1-0.20.2
Total heroin consumption1.92.22.21.5-1.5
Bone: trabecular number0.71.11.2-1.01.1
Bone: trabecular spacing0.00.00.00.2-0.1
Bone: trabecular thickness1.31.61.8-1.21.4
Bone: trabecular tissue density0.10.10.20.4-0.3
Water consumed over 24 hours0.30.30.30.6-0.6
Number of responses in last shaping day0.00.00.00.00.0