Prr14l

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Prr14l	0.14	0.06	0.0e+00	0.07	0.13	0.14	0.14	2.9e-11	1.9e-19	3.0e-20	5.5e-20
2	PL	gene expression	Prr14l	0.04	0.03	1.6e-03	0.02	0.03	0.03	0.03	3.5e-03	4.6e-04	5.1e-04	9.4e-04
3	Brain	gene expression	Prr14l	0.15	0.07	1.2e-09	0.09	0.1	0.11	0.1	6.7e-09	1.3e-09	4.1e-10	8.3e-10
4	Adipose	intron excision ratio	chr14_82094515_82104182	0.05	0.03	2.3e-03	0.02	0.02	0.01	0.02	1.3e-03	3.2e-03	2.1e-02	3.8e-03
5	Adipose	alternative polyA	XM_039092537.2	0.08	0.05	3.4e-05	0.04	0.03	0.03	0.03	2.2e-05	3.1e-04	2.0e-04	4.0e-04
6	Adipose	gene expression	Prr14l	0.14	0.07	5.6e-11	0.1	0.1	0.1	0.01	4.1e-11	8.0e-11	8.9e-11	2.6e-02
7	Adipose	alternative polyA	XM_223586.10	0.08	0.05	8.7e-05	0.03	0.03	0.03	0.03	3.1e-04	7.8e-04	2.6e-04	1.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.6	1.0	2.2	1.5	1.5	1.3	-1.0	-0.1	0.1	0.4
Area under the delay curve	7.4	8.6	10.4	-3.2	-3.0	-3.0	3.2	2.7	-2.7	-2.6
BMI with tail	1.5	5.0	10.4	-3.1	-3.2	-3.1	2.2	0.1	-0.1	-0.9
BMI without tail	0.8	2.4	5.9	-2.2	-2.4	-1.8	1.0	-0.8	0.8	0.5
Body weight	3.2	13.8	28.4	-5.3	-5.2	-5.0	3.7	0.2	-0.2	-1.4
Weight adjusted by age	1.0	1.5	4.7	-1.7	-2.2	-1.3	1.1	-0.2	0.2	0.1
Bone surface	0.0	0.0	0.0	0.0	0.1	0.1	-0.2	-0.2	0.2	0.1
Bone volume	0.1	0.1	0.2	0.4	0.5	0.5	-0.5	-0.2	0.2	0.2
Breakpoint value in progressive ratio session	0.3	0.3	1.5	-1.2	-0.2	-0.3	0.4	0.4	-0.4	-0.5
Number of licking bursts	0.3	0.4	0.8	-0.9	-0.6	-0.2	-0.1	-0.8	0.8	0.6
Context. condit. distance diff. score	1.3	1.6	2.2	1.3	1.1	1.5	-1.5	-1.1	1.1	1.2
Locomotion velocity, session 1	0.6	0.6	1.4	1.1	1.2	1.0	-0.7	0.1	-0.1	0.0
Locomotion distance, session 1	0.8	1.0	1.5	1.2	1.2	1.2	-1.2	-0.6	0.6	0.7
Locomotion velocity, session 2	2.5	2.9	8.8	2.1	3.0	2.1	-1.2	0.7	-0.7	-0.4
Locomotion distance, session 2	1.4	2.0	4.1	2.0	2.0	1.8	-1.5	0.1	-0.1	0.3
Locomotion velocity, session 3	0.3	0.3	0.6	0.5	0.6	0.8	-0.8	-0.4	0.4	0.4
Locomotion distance, session 3	0.6	0.7	0.9	-0.8	-0.7	-0.8	0.9	0.9	-0.9	-0.8
Stereotopy head waving bouts, day 3	1.6	1.9	2.5	1.5	1.4	1.5	-1.6	-1.2	1.2	1.2
Stereotopy head waving duration, day 3	2.9	3.4	4.6	1.9	1.5	1.9	-2.1	-1.8	1.8	1.8
Locomotion velocity, session 7	0.6	0.7	1.6	-1.3	-0.6	-1.0	0.9	0.5	-0.5	-0.7
Locomotion distance, session 7	0.1	0.1	0.2	-0.1	0.5	0.3	-0.3	0.1	-0.1	-0.1
Stereotopy head waving bouts, day 7	0.6	0.7	1.9	-1.2	-1.4	-1.0	0.6	-0.4	0.4	0.1
Stereotopy head waving duration, day 7	0.8	1.0	2.3	-1.3	-1.5	-1.0	0.4	-0.8	0.8	0.4
Locomotion velocity, session 8	2.6	3.1	5.6	2.3	2.4	2.2	-1.9	-0.8	0.8	1.0
Locomotion distance, session 8	5.6	8.2	12.0	3.2	3.0	3.5	-3.4	-2.1	2.1	2.4
Degree of sensitization distance	3.8	3.9	5.8	1.9	2.2	2.4	-2.4	-1.5	1.5	1.7
Degree of sensitization stereotypy	0.9	1.0	2.7	-1.4	-1.6	-1.2	0.7	-0.4	0.4	0.1
Conditioned locomotion	0.0	0.0	0.1	-0.2	-0.3	-0.1	-0.1	-0.2	0.2	0.3
Cocaine response after cond. corrected	0.4	0.5	1.0	0.5	0.4	0.1	0.3	1.0	-1.0	-0.9
Cocaine response after cond. not corrected	0.6	0.7	1.5	-0.1	-0.2	-0.4	0.7	1.2	-1.2	-1.2
Cocaine response before conditioning	0.2	0.2	0.7	-0.8	-0.6	-0.6	0.4	-0.1	0.1	-0.1
Saline control response	0.1	0.1	0.2	0.4	0.4	0.2	-0.0	0.3	-0.3	-0.1
Bone: connectivity density	0.4	0.6	1.6	1.2	1.1	1.0	-0.8	0.0	-0.0	0.2
Bone: cortical apparent density	0.3	0.4	0.9	-0.9	-1.0	-0.6	0.2	-0.4	0.4	0.2
Bone: cortical area	3.4	5.2	11.9	-3.5	-3.3	-2.8	2.2	0.2	-0.2	-0.5
Bone: cortical porosity	0.5	0.5	1.3	0.1	0.1	-0.3	0.7	1.1	-1.1	-0.9
Bone: cortical porosity	0.1	0.1	0.2	-0.0	-0.1	-0.2	0.3	0.4	-0.4	-0.3
Bone: cortical thickness	3.1	5.1	11.4	-3.4	-3.4	-2.8	2.2	0.3	-0.3	-0.4
Bone: cortical thickness	0.4	0.4	1.0	-0.1	-0.5	0.2	-0.6	-0.8	0.8	1.0
Bone: cortical tissue density	0.3	0.4	0.9	-0.9	-0.9	-0.6	0.2	-0.4	0.4	0.1
Condit. Reinf. active minus inactive responses	0.7	0.8	1.9	-0.1	0.1	-0.3	0.8	1.4	-1.4	-1.1
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.3	1.1	1.1	0.5	0.1	1.1	-1.1	-0.7
Condit. Reinf. active responses	0.1	0.1	0.2	0.0	0.2	0.1	0.1	0.5	-0.5	-0.2
Condit. Reinf. inactive responses	0.5	0.6	1.2	-0.8	-0.7	-0.1	-0.4	-1.1	1.1	0.8
Incentive salience index mean	0.8	1.0	1.3	-1.0	-0.6	-0.8	1.1	1.1	-1.1	-1.1
Condit. Reinf. lever presses	0.6	0.9	2.6	-1.6	-1.3	-1.0	0.7	0.1	-0.1	-0.3
Condit. Reinf. active minus inactive responses	0.5	0.6	1.1	0.0	0.2	0.6	-0.8	-1.1	1.1	1.0
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.2	-0.3	-0.3	0.3	0.4	-0.4	-0.4
Condit. Reinf. active responses	0.4	0.5	0.8	0.7	0.8	0.9	-0.8	-0.6	0.6	0.7
Condit. Reinf. inactive responses	0.8	1.0	1.4	1.0	1.2	1.2	-1.1	-0.8	0.8	0.9
Condit. Reinf. lever presses	0.1	0.2	0.4	-0.4	-0.4	-0.0	-0.2	-0.6	0.6	0.5
Condit. Reinf. lever reinforcers received	0.1	0.2	0.2	0.3	0.4	0.4	-0.4	-0.4	0.4	0.4
Conditioned reinforcement - actives	1.5	2.5	3.9	-1.2	-1.8	-2.0	2.0	1.3	-1.3	-1.3
Conditioned reinforcement - inactives	2.3	3.3	4.9	-1.6	-2.0	-2.2	2.2	1.5	-1.5	-1.6
Conditioned locomotion	1.7	2.3	4.5	-2.1	-1.9	-1.8	1.7	0.8	-0.8	-0.6
Patch foraging indifference point 0 sec	0.1	0.1	0.2	-0.2	-0.4	0.1	-0.2	-0.4	0.4	0.5
Patch foraging indifference point AUC	0.1	0.2	0.8	0.5	0.9	0.4	-0.1	0.2	-0.2	-0.3
Delay disc. indifference point, 0s delay	6.5	7.2	9.2	-2.6	-3.0	-3.0	2.9	2.3	-2.3	-2.4
Delay disc. indifference point, 16s delay	4.7	5.2	7.9	-1.6	-1.2	-2.1	2.5	2.6	-2.6	-2.8
Delay disc. indifference point, 2s delay	3.6	4.1	5.3	-2.3	-2.3	-2.0	2.1	1.9	-1.9	-1.7
Delay disc. indifference point, 24s delay	3.3	3.7	5.1	-1.6	-1.7	-2.1	2.1	1.8	-1.8	-2.3
Delay disc. indifference point, 4s delay	5.0	5.2	6.4	-2.5	-2.2	-2.0	2.4	2.5	-2.5	-1.8
Delay disc. indifference point, 8s delay	2.0	2.3	4.2	-2.0	-2.0	-1.6	1.6	1.0	-1.0	-0.8
Indifference point function ln k	0.0	0.1	0.1	0.3	0.3	0.3	-0.0	0.3	-0.3	-0.1
Indifference point function log k	0.0	0.1	0.1	0.3	0.3	0.3	-0.0	0.3	-0.3	-0.1
Patch foraging total patch changes 0 sec	0.1	0.1	0.3	-0.3	-0.5	-0.0	-0.0	-0.3	0.3	0.4
Patch foraging total patch changes 12 sec	0.3	0.3	0.9	-0.9	-1.0	-0.5	0.3	-0.2	0.2	0.2
Patch foraging total patch changes 18 sec	0.1	0.1	0.3	-0.6	-0.2	0.0	-0.1	-0.3	0.3	0.2
Patch foraging total patch changes 24 sec	1.2	2.1	3.5	0.7	0.2	1.1	-1.6	-1.9	1.9	1.9
Patch foraging total patch changes 6 sec	0.1	0.2	0.7	-0.8	-0.6	-0.4	0.5	0.1	-0.1	-0.1
Patch foraging time to switch 0 sec	0.7	1.4	2.6	-0.6	-1.1	0.0	-0.7	-1.6	1.6	1.5
Patch foraging water rate 0 sec	0.2	0.5	0.8	-0.8	-0.5	-0.7	0.9	0.6	-0.6	-0.5
Patch foraging water rate 12 sec	0.0	0.0	0.1	-0.1	-0.2	0.1	-0.1	0.0	-0.0	0.2
Patch foraging water rate 18 sec	0.7	1.2	3.0	0.2	-0.0	0.8	-1.1	-1.3	1.3	1.7
Patch foraging water rate 24 sec	0.5	0.7	1.9	-0.4	-0.4	0.3	-0.5	-1.0	1.0	1.4
Patch foraging water rate 6 sec	0.6	0.9	1.5	-1.0	-0.7	0.0	-0.5	-1.2	1.2	1.2
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	2.2	0.7	1.5	0.8	-0.4	0.6	-0.6	-0.7
Distance traveled before self-admin	0.3	0.4	1.0	0.9	1.0	0.7	-0.5	0.4	-0.4	-0.3
Distance traveled after self-admin	0.1	0.2	0.5	-0.1	0.0	-0.4	0.3	0.4	-0.4	-0.7
Extensor digitorum longus weight	2.1	8.4	18.4	-4.3	-3.8	-3.6	3.0	0.7	-0.7	-1.4
Bone: elastic displacement	0.5	0.6	1.2	-0.3	-0.2	0.3	-0.6	-1.1	1.1	1.1
Bone: elastic work	1.2	1.5	2.8	-1.1	-1.1	-0.3	-0.3	-1.7	1.7	1.5
Bone: endosteal estimation	0.2	0.5	1.3	-0.2	0.1	0.3	-0.6	-1.2	1.2	0.8
Bone: endosteal perimeter	0.2	0.5	1.1	-1.1	-0.8	-0.9	0.8	0.1	-0.1	-0.3
Epididymis fat weight	1.3	4.4	8.7	-2.8	-2.9	-2.8	2.2	0.4	-0.4	-1.0
Delta time in closed arm before/after self-admin	1.3	1.2	2.5	1.6	1.1	1.1	-1.4	-0.8	0.8	0.6
Delta time in open arm before/after self-admin	4.7	4.6	8.3	-2.9	-2.5	-2.4	2.4	1.5	-1.5	-1.4
Diff in mean of infusions in LGA sessions	0.3	0.4	0.9	1.0	0.6	0.5	-0.3	0.6	-0.6	-0.6
Delay discount exponential model param	7.1	7.9	9.4	3.1	2.9	2.8	-3.1	-2.6	2.6	2.4
Extinction: sum of active levers before priming	1.3	1.4	3.1	-1.2	-0.5	-1.6	1.4	0.6	-0.6	-1.8
Active lever presses in extinction session 6	1.1	1.1	1.8	-1.1	-0.5	-1.0	1.1	1.0	-1.0	-1.3
Bone: final force	1.3	2.0	3.1	-1.7	-1.6	-0.8	-0.1	-1.8	1.8	1.2
Bone: final moment	1.0	1.6	2.6	-1.6	-1.4	-0.7	-0.0	-1.6	1.6	1.0
Food consumed during 24 hour testing period	0.0	0.0	0.2	0.3	0.4	0.2	0.0	0.1	-0.1	-0.0
Glucose	5.4	8.5	14.1	-1.9	-1.0	-2.4	3.3	3.5	-3.5	-3.8
Heart weight	0.6	1.0	1.8	-1.3	-1.1	-1.3	1.2	0.4	-0.4	-0.5
Delay discount hyperbolic model param	7.1	7.9	9.4	3.1	3.0	2.8	-3.1	-2.6	2.6	2.4
Intermittent access intake day 1-15 change	0.7	1.4	3.8	-0.2	-0.0	0.1	0.6	1.9	-1.9	-1.3
Intermittent access intake escalation	0.7	1.5	3.6	-0.6	-0.2	-0.2	0.8	1.9	-1.9	-1.4
Intermittent access intake escalation 2	0.3	0.4	1.0	-0.1	0.2	0.6	-0.1	1.0	-1.0	-0.3
Intermitt. access day 1 inactive lever presses	0.3	1.1	2.1	-0.2	-0.7	-0.8	1.1	1.4	-1.4	-1.0
Intermitt. access day 15 inactive lever presses	1.3	2.7	4.6	-1.5	-1.3	-1.1	1.7	2.1	-2.1	-1.3
Intermitt. access escalation Index	0.5	0.8	1.6	1.3	1.0	1.2	-1.0	-0.2	0.2	0.4
Intermittent access day 1 total infusions	0.9	1.5	2.9	-1.1	-1.5	-1.7	1.5	0.6	-0.6	-1.0
Intermittent access day 15 total infusions	1.9	2.9	3.5	-1.3	-1.5	-1.7	1.9	1.8	-1.8	-1.8
Intermittent access terminal intake (last 3 days)	1.2	1.5	1.9	-1.0	-1.0	-1.1	1.3	1.4	-1.4	-1.4
Intermittent access total infusions	1.8	2.1	3.1	-1.1	-1.1	-1.6	1.8	1.4	-1.4	-1.6
Intermittent access day 1 locomotion	0.1	0.1	0.4	0.0	-0.1	-0.7	0.4	-0.2	0.2	-0.2
Intermittent access day 15 total locomotion	3.1	5.7	7.9	-2.7	-2.8	-2.5	2.7	2.1	-2.1	-1.5
Intermittent access total locomotion	2.4	2.9	4.1	-1.5	-1.4	-1.8	2.0	1.7	-1.7	-1.6
Intermittent access standard deviation	0.1	0.2	0.3	-0.4	-0.6	0.0	0.1	0.6	-0.6	-0.1
Left kidney weight	1.1	4.9	9.2	-3.0	-2.9	-2.3	0.9	-2.1	2.1	1.3
Right kidney weight	1.1	5.0	11.2	-3.3	-3.3	-2.5	1.3	-1.4	1.4	0.9
Cocaine induced anxiety	2.1	3.0	5.8	-0.4	-0.4	-1.1	1.9	2.4	-2.4	-2.0
Post-drug Anxiety	3.1	3.3	5.0	-0.9	-1.1	-1.6	2.1	2.2	-2.2	-2.0
Baseline Anxiety	0.6	0.6	1.4	-1.2	-0.9	-0.9	0.1	-0.9	0.9	0.1
Tail length	0.4	1.6	3.7	-1.9	-1.7	-1.6	1.4	0.2	-0.2	-0.1
Length with tail	1.0	4.3	10.5	-3.2	-2.9	-2.7	1.9	-0.5	0.5	-0.1
Length without tail	0.8	2.7	6.0	-2.5	-2.2	-2.2	1.5	-0.3	0.3	-0.5
Times rat made contact with spout	0.5	0.6	1.9	1.0	1.4	0.9	-0.5	0.2	-0.2	-0.1
Lifetime Intake	1.6	1.9	3.0	-1.0	-0.9	-1.6	1.7	1.3	-1.3	-1.6
Liver weight, left	0.2	0.2	0.4	-0.7	-0.6	-0.3	0.1	-0.5	0.5	0.6
Liver weight, right	1.2	2.1	4.0	-1.4	-1.3	-0.5	-0.4	-2.0	2.0	1.6
Locomotor activity	0.0	0.1	0.1	-0.2	0.4	0.3	-0.2	-0.2	0.2	0.1
Locomotor testing distance	0.5	0.9	2.9	-1.7	-1.3	-1.0	0.9	0.2	-0.2	-0.3
Locomotor testing rearing	0.6	1.3	3.7	-1.9	-1.1	-1.4	1.2	0.2	-0.2	-0.8
Locomotion in novel chamber	0.1	0.1	0.2	0.0	0.0	0.3	-0.2	0.4	-0.4	0.0
Locomotion in novel chamber post-restriction	0.5	0.8	1.8	1.3	1.3	0.9	-0.9	-0.5	0.5	0.2
Fecal boli incidents, locomotor time 1	0.2	0.3	0.9	1.0	0.7	0.5	-0.2	0.4	-0.4	-0.2
Change in fecal boli incidents, locomotor task	0.8	0.8	1.8	0.6	1.4	1.3	-1.1	-0.5	0.5	0.5
Time >=10cm from walls, locomotor time 1	0.5	0.6	1.6	-0.0	-0.7	-0.5	-0.3	-1.2	1.2	0.4
Bouts of movement, locomotor time 1	0.1	0.1	0.1	-0.4	-0.1	-0.3	0.4	0.2	-0.2	-0.3
Total resting periods, locomotor time 1	0.2	0.2	0.5	-0.7	-0.3	-0.4	0.6	0.4	-0.4	-0.5
Rest time, locomotor task time 1	0.3	0.4	1.0	-0.7	-0.1	-0.1	-0.1	-1.0	1.0	0.4
Distance moved, locomotor task time 1	0.0	0.0	0.2	0.4	-0.1	0.1	-0.1	0.1	-0.1	0.1
Vertical activity count, locomotor time 1	0.4	0.9	2.7	1.7	1.4	0.9	-0.7	0.1	-0.1	-0.2
Time >=10cm from walls, locomotor time 2	0.2	0.3	1.0	0.0	0.1	-0.2	-0.2	-1.0	1.0	0.3
Bouts of movement, locomotor time 2	0.6	1.0	1.5	-1.2	-1.1	-0.7	1.0	1.1	-1.1	-0.4
Total resting periods, locomotor time 2	0.6	1.0	1.9	-1.4	-1.2	-0.9	1.1	0.9	-0.9	-0.5
Rest time, locomotor task time 2	0.7	0.9	2.3	-0.3	0.1	0.3	-0.7	-1.5	1.5	0.8
Distance moved, locomotor task time 2	0.2	0.2	0.8	0.9	0.2	0.5	-0.4	0.1	-0.1	0.3
Vertical activity count, locomotor time 2	0.5	0.6	1.1	1.1	0.8	0.4	-0.0	1.0	-1.0	-0.8
Light reinforcement 1	0.6	1.4	3.6	-1.6	-1.9	-1.1	0.5	-0.9	0.9	0.7
Light reinforcement 2	1.0	1.6	2.6	-1.0	-1.4	-0.3	-0.4	-1.6	1.6	1.6
Bone: marrow area	0.2	0.5	1.2	-0.2	0.1	0.3	-0.6	-1.1	1.1	0.8
Bone: maximum diameter	2.7	5.0	11.0	-3.3	-3.0	-2.9	2.4	0.5	-0.5	-0.9
Bone: maximum force	0.9	1.7	2.8	-1.4	-1.4	-0.6	-0.2	-1.7	1.7	1.3
Bone: maximum moment	0.7	1.3	2.2	-1.2	-1.2	-0.5	-0.2	-1.5	1.5	1.2
Mean time between licks in bursts	0.5	1.3	3.6	1.4	1.9	1.5	-1.0	-0.1	0.1	0.4
Mean num. licks in bursts	0.7	1.2	2.6	1.6	1.6	0.9	-0.2	0.9	-0.9	-0.6
Cd content in liver	0.1	0.1	0.3	0.2	0.1	-0.1	0.3	0.6	-0.6	-0.2
Co content in liver	1.4	1.6	2.1	-1.1	-1.1	-1.3	1.5	1.3	-1.3	-1.2
Cu content in liver	0.6	0.7	1.7	0.5	0.2	0.0	0.5	1.3	-1.3	-1.0
Fe content in liver	1.2	1.4	2.9	1.7	1.2	0.7	-0.0	1.5	-1.5	-0.8
K content in liver	3.4	3.3	4.2	-1.4	-1.5	-1.7	2.1	1.9	-1.9	-2.0
Mg content in liver	3.0	3.0	4.6	-2.2	-2.0	-2.0	1.9	1.1	-1.1	-1.6
Mn content in liver	0.2	0.2	0.5	-0.0	0.4	0.1	0.2	0.7	-0.7	-0.7
Na content in liver	6.6	7.0	10.8	-1.8	-1.3	-2.3	2.9	3.2	-3.2	-3.3
Rb content in liver	0.6	0.7	0.9	-0.8	-0.9	-0.9	1.0	0.7	-0.7	-0.8
Se content in liver	1.7	2.0	2.7	-1.0	-1.0	-1.4	1.6	1.6	-1.6	-1.6
Sr content in liver	2.4	2.0	3.9	-2.0	-1.6	-1.7	1.7	0.9	-0.9	-0.8
Zn content in liver	0.1	0.1	0.4	-0.7	-0.5	-0.3	0.4	-0.1	0.1	0.0
Bone: minimum diameter	0.3	0.5	0.9	-0.6	-0.5	-0.1	-0.3	-1.0	1.0	0.9
Time in familiar zone, hab. session 1	1.7	1.7	2.5	1.4	1.1	1.5	-1.6	-1.0	1.0	1.3
Time in novel zone, hab. session 1	0.8	0.8	1.3	-1.1	-0.8	-1.1	1.1	0.6	-0.6	-0.8
Total zone transitions, hab. session 1	0.3	0.4	0.6	0.6	0.7	0.8	-0.8	-0.4	0.4	0.5
Total locomotion distance, hab. session 1	0.2	0.3	0.9	0.6	0.9	0.5	-0.2	0.5	-0.5	-0.5
Locomotion velocity, hab. session 1	0.1	0.2	0.5	0.5	0.7	0.4	-0.2	0.3	-0.3	-0.3
Time in familiar zone, hab. session 2	2.9	3.1	6.6	2.6	1.8	2.2	-2.0	-0.7	0.7	1.4
Time in novel zone, hab. session 2	3.3	3.3	7.8	-2.8	-2.3	-2.4	2.0	0.2	-0.2	-0.7
Total zone transitions, hab. session 2	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.2	0.0	-0.0	0.0
Total locomotion distance, hab. session 2	0.1	0.1	0.2	-0.2	-0.1	-0.3	0.4	0.4	-0.4	-0.3
Locomotion velocity, hab. session 2	0.2	0.3	0.5	-0.4	-0.3	-0.6	0.7	0.7	-0.7	-0.6
Novel to familiar place preference ratio	1.9	2.1	3.5	-1.0	-0.7	-1.1	1.5	1.7	-1.7	-1.9
Novelty place preference	1.8	2.0	3.2	-1.0	-0.7	-1.2	1.5	1.6	-1.6	-1.8
Time in novel zone, NPP test	1.6	1.7	2.6	-1.0	-0.7	-1.1	1.4	1.5	-1.5	-1.6
Total zone transitions, NPP test	0.0	0.0	0.0	-0.0	-0.1	0.0	-0.1	0.1	-0.1	-0.0
Total locomotion distance, NPP test	0.4	0.5	1.1	-0.0	-0.0	-0.3	0.6	1.0	-1.0	-1.0
Locomotion velocity, NPP test	0.6	0.9	1.9	0.0	-0.0	-0.4	0.8	1.4	-1.4	-1.3
Intraocular pressure	0.2	0.2	0.4	-0.7	-0.5	-0.4	0.0	-0.6	0.6	0.4
Delta distance traveled before/after self-admin	0.8	0.9	2.1	-1.5	-1.1	-1.1	0.9	0.3	-0.3	-0.5
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.5	-0.2	-0.3	0.3	0.5	-0.5	-0.4
Parametrial fat weight	1.1	2.7	4.4	-0.9	-0.7	-1.3	1.7	2.1	-2.1	-2.0
Pavlov. Cond. lever latency	0.3	0.4	0.7	0.8	0.7	0.3	0.2	0.8	-0.8	-0.5
Pavlov. Cond. magazine entry latency	1.0	1.3	2.1	1.1	1.3	1.4	-1.4	-0.9	0.9	0.9
Pavlov. Cond. change in total contacts	0.6	0.7	1.0	-0.7	-0.6	-0.7	0.8	0.9	-0.9	-1.0
Pavlov. Cond. index score	0.4	0.5	0.8	0.5	0.5	0.7	-0.9	-0.7	0.7	0.6
Pavlov. Cond. latency score	0.4	0.5	0.8	0.4	0.4	0.7	-0.9	-0.9	0.9	0.7
Pavlov. Cond. lever contacts	0.3	0.3	0.7	-0.5	-0.3	0.0	-0.4	-0.8	0.8	0.6
Pavlov. Cond. magazine entry number	0.5	0.7	1.4	-0.9	-1.2	-1.1	1.0	0.3	-0.3	-0.2
Pavlov. Cond. intertrial magazine entries	0.9	1.0	1.9	-1.4	-1.3	-1.2	1.1	0.6	-0.6	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.9	0.4	0.5	0.7	-0.9	-0.8	0.8	0.7
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.0	0.4	0.4	-0.4	-0.2	0.2	-0.1
Pavlov. Cond. lever latency	0.6	0.8	1.4	-1.0	-1.2	-1.2	1.1	0.5	-0.5	-0.5
Pavlov. Cond. magazine entry latency	0.3	0.4	1.0	-1.0	-0.8	-0.5	0.1	-0.6	0.6	0.3
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.2	0.1	0.3	-0.4	-0.5	0.5	0.4
Pavlov. Cond. index score	0.2	0.3	0.5	0.2	0.3	0.5	-0.7	-0.7	0.7	0.6
Pavlov. Cond. latency score	0.3	0.4	0.7	0.3	0.4	0.6	-0.8	-0.8	0.8	0.7
Pavlov. Cond. lever contacts	0.6	0.9	1.7	1.3	1.3	1.3	-1.0	-0.3	0.3	0.4
Pavlov. Cond. magazine entry number	0.6	0.7	1.6	0.8	0.5	0.1	0.4	1.3	-1.3	-0.9
Pavlov. Cond. intertrial magazine entries	0.3	0.5	1.1	0.5	0.4	0.0	0.4	1.0	-1.0	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.5	0.8	0.2	0.3	0.6	-0.8	-0.9	0.9	0.7
Pavlov. Cond. response bias	0.2	0.3	0.5	0.4	0.6	0.7	-0.7	-0.5	0.5	0.4
Time in closed arm before self-admin	0.4	0.5	1.1	0.9	0.1	0.5	-0.5	-0.7	0.7	1.0
Time in closed arm after self-admin	1.4	1.5	3.6	1.9	0.9	1.1	-1.4	-1.0	1.0	1.0
Time in open arm before self-admin	0.3	0.3	0.7	-0.2	0.2	0.3	-0.6	-0.8	0.8	0.6
Time in open arm after self-admin	1.3	1.4	5.1	-2.3	-1.4	-1.2	1.0	0.2	-0.2	-0.4
Bone: periosteal estimation	0.8	1.6	4.2	-2.0	-1.8	-1.3	0.7	-0.8	0.8	0.4
Bone: periosteal perimeter	2.0	3.5	7.6	-2.8	-2.6	-2.3	1.9	0.4	-0.4	-0.8
Bone: post-yield work	0.2	0.3	0.8	0.9	0.8	0.5	-0.3	0.2	-0.2	-0.0
Progressive ratio test 1 active lever presses	2.1	2.6	4.9	-1.2	-0.8	-2.1	2.0	1.2	-1.2	-2.2
Progressive ratio test 1 breakpoint	2.2	2.7	5.0	-1.2	-0.8	-2.2	2.0	1.2	-1.2	-2.2
Progressive ratio test 1 inactive lever presses	3.7	5.3	7.9	-1.9	-1.5	-2.6	2.8	2.2	-2.2	-2.6
Progressive ratio test 2 active lever presses	1.2	1.4	2.0	-0.6	-1.0	-1.4	1.4	1.2	-1.2	-1.4
Progressive ratio test 2 breakpoint	1.1	1.3	1.8	-0.6	-1.0	-1.3	1.4	1.1	-1.1	-1.3
Progressive ratio test 2 inactive lever presses	2.9	4.6	7.2	-2.4	-2.7	-2.4	2.4	1.7	-1.7	-1.4
Incentive Sensitization - Responses	0.3	0.5	1.3	-0.5	-1.1	-0.5	0.7	0.8	-0.8	-0.1
Incentive Sensitization - Breakpoint	0.3	0.4	1.3	-0.4	-1.1	-0.4	0.5	0.6	-0.6	0.0
Sum of active levers in priming session hrs 5-6	0.9	0.8	1.6	-0.9	-0.4	-0.9	1.0	0.9	-0.9	-1.3
Progressive ratio	0.1	0.2	0.8	-0.9	-0.6	-0.4	0.3	0.1	-0.1	0.1
Food seeking constrained by brief footshock	2.6	3.1	5.5	-2.3	-2.3	-2.1	1.9	0.9	-0.9	-1.0
Seeking ratio, punishment vs. effort	0.3	0.4	0.7	-0.2	-0.7	-0.7	0.8	0.7	-0.7	-0.6
Retroperitoneal fat weight	0.4	1.7	3.3	-1.8	-1.8	-1.6	1.4	0.6	-0.6	-0.7
Reaction time number correct	0.5	1.0	2.3	0.3	0.8	0.5	-0.8	-1.5	1.5	1.0
Reaction time mean minus median	0.1	0.3	0.6	0.6	0.8	0.5	-0.2	0.6	-0.6	-0.5
Reaction time mean minus median AUC	0.1	0.3	0.7	-0.9	-0.6	-0.6	0.4	0.1	-0.1	-0.4
Reaction time num false alarms	1.3	1.8	4.0	-2.0	-2.0	-1.6	1.2	0.4	-0.4	-0.6
Reaction time num false alarms AUC	1.1	1.7	4.7	-2.0	-2.2	-1.5	1.0	-0.1	0.1	-0.2
Reaction time trials correct on left	0.5	1.0	2.3	0.3	0.8	0.5	-0.8	-1.5	1.5	1.0
Reaction time trials on left	0.6	1.0	2.3	0.4	0.8	0.5	-0.8	-1.5	1.5	1.0
Reaction time mean	0.2	0.4	1.1	1.0	0.7	0.4	-0.3	0.5	-0.5	-0.4
Reaction time mean AUC	0.2	0.3	0.9	1.0	0.6	0.4	-0.3	0.5	-0.5	-0.3
Median of all reaction times	0.2	0.3	1.2	1.1	0.6	0.4	-0.4	0.4	-0.4	-0.3
Reaction time omissions	0.1	0.2	0.9	0.9	0.5	0.4	-0.3	0.0	-0.0	-0.1
Reaction time false alarm rate	1.7	2.3	6.0	-2.2	-2.4	-1.7	1.3	0.6	-0.6	-0.6
Reaction time premature initiation rate	2.8	3.8	5.7	1.4	0.9	1.7	-2.2	-2.4	2.4	2.3
Reaction time premature initiations	2.4	4.4	7.4	1.3	1.1	1.6	-2.2	-2.7	2.7	2.3
Std. dev. reaction times	0.1	0.2	0.6	0.8	0.4	0.3	-0.3	0.3	-0.3	-0.3
Reaction time trials completed	0.6	1.0	2.3	0.4	0.8	0.5	-0.8	-1.5	1.5	1.0
Reaction time trials AUC	0.4	0.8	1.7	0.4	0.9	0.4	-0.7	-1.3	1.3	0.8
Run reversals in cocaine runway, females	0.2	0.2	0.8	0.9	0.0	0.3	-0.2	0.5	-0.5	-0.2
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.4	-0.2	-0.5	0.3	-0.1	0.1	-0.1
Latency to leave start box in cocaine runway	0.4	0.5	1.2	-1.1	-0.7	-0.9	0.8	0.2	-0.2	-0.4
Latency to leave start box in cocaine runway, F	1.2	1.3	4.2	-2.0	-1.7	-1.1	0.7	-0.4	0.4	0.3
Latency to leave start box in cocaine runway, M	0.7	0.7	1.5	0.5	0.6	-0.5	0.7	1.0	-1.0	-1.2
Std. dev. time between licks in bursts	1.7	2.2	3.3	1.0	1.7	1.8	-1.8	-1.4	1.4	1.3
Total sessions with >9 infusions	0.1	0.1	0.2	-0.1	-0.1	-0.5	0.5	0.2	-0.2	-0.4
Short access day 1 total inactive lever presses	1.9	2.5	4.5	-2.1	-1.6	-1.4	1.7	1.5	-1.5	-1.0
Short access day 10 total inactive lever presses	0.3	0.6	1.2	-1.1	-0.6	-0.0	0.5	1.1	-1.1	-0.1
Short access day 1 total infusions	0.2	0.2	0.4	-0.4	-0.6	-0.6	0.6	0.4	-0.4	-0.3
Short access day 10 total infusions	0.1	0.1	0.2	0.4	0.4	0.1	-0.2	-0.2	0.2	-0.1
Short access total infusions	0.2	0.3	0.4	-0.1	-0.2	-0.5	0.7	0.6	-0.6	-0.7
Short access day 1 locomotion	0.3	0.4	0.8	0.0	0.2	0.2	-0.4	-0.9	0.9	0.8
Short access day 10 total locomotion	0.8	1.5	3.9	1.7	2.0	1.5	-1.1	-0.1	0.1	0.3
Short access total locomotion	0.9	1.1	2.0	1.3	1.4	1.2	-1.0	-0.6	0.6	0.8
One hour access (0.3 mA shock)	0.9	1.0	2.0	-0.9	-0.4	-1.0	1.2	1.0	-1.0	-1.4
Compulsive drug intake	1.4	1.6	2.5	1.0	1.4	1.5	-1.6	-1.2	1.2	1.0
One hour access (shock baseline)	2.2	3.3	4.8	-1.1	-1.1	-1.9	2.2	1.9	-1.9	-2.2
Social response proportion	1.0	1.1	3.4	1.9	1.5	1.2	-0.7	0.0	-0.0	0.3
Social responses	0.1	0.1	0.6	0.4	0.8	0.3	-0.2	-0.3	0.3	0.0
Social time	1.3	1.8	6.2	2.5	1.9	1.4	-0.9	0.2	-0.2	0.1
Soleus weight	0.9	2.7	7.0	-2.6	-2.3	-1.8	1.0	-1.1	1.1	0.5
Bone: stiffness	0.2	0.4	1.2	-0.8	-1.1	-0.8	0.4	-0.2	0.2	0.1
Tibialis anterior weight	1.2	4.1	8.9	-3.0	-2.7	-2.6	2.2	0.5	-0.5	-1.0
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.3	-0.3	-0.1	0.3	0.7	-0.7	-0.2
Time to tail flick, vehicle, after self-admin	0.3	0.3	1.2	1.1	0.8	0.3	-0.2	0.3	-0.3	-0.6
Time to tail flick, test, before self-admin	0.1	0.1	0.3	0.5	0.1	-0.2	0.2	0.0	-0.0	-0.1
Time to tail flick, test, after self-admin	1.2	1.3	2.4	-0.6	-1.1	-1.3	1.6	1.1	-1.1	-0.9
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	0.6	0.7	0.2	-0.3	-0.4	0.4	-0.2
Delta time to tail flick, test, before/after SA	0.3	0.3	0.5	-0.5	-0.5	-0.5	0.7	0.7	-0.7	-0.5
Tibia length	0.4	1.2	2.4	-0.7	-0.9	-0.0	-0.6	-1.5	1.5	1.5
Ambulatory time before self-admin	0.2	0.3	0.6	0.4	0.7	0.3	-0.2	0.5	-0.5	-0.7
Ambulatory time after self-admin	0.3	0.3	0.7	0.4	0.6	0.1	0.0	0.8	-0.8	-0.8
Bone: tissue strength	1.3	1.3	2.9	0.0	0.2	0.5	-0.9	-1.7	1.7	1.5
Total heroin consumption	0.3	0.4	0.9	-0.4	0.1	0.2	-0.4	-1.0	1.0	0.6
Bone: trabecular number	0.3	0.5	0.9	0.9	0.9	0.8	-0.7	-0.3	0.3	0.4
Bone: trabecular spacing	0.4	0.5	1.4	-1.2	-1.0	-0.8	0.6	-0.1	0.1	-0.1
Bone: trabecular thickness	1.0	1.3	2.1	1.5	1.3	1.4	-1.3	-0.6	0.6	0.9
Bone: trabecular tissue density	0.1	0.2	0.4	0.1	0.1	-0.0	0.2	0.7	-0.7	-0.6
Water consumed over 24 hours	1.2	1.6	3.4	1.5	1.8	1.7	-1.3	-0.4	0.4	0.9
Number of responses in last shaping day	0.3	0.3	0.5	-0.4	-0.6	-0.7	0.6	0.5	-0.5	-0.7