Hub : Genes

Prr13

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC mRNA stability Prr13 0.07 0.04 2.1e-03 0.03 0.06 0.07 0.05 2.6e-02 1.7e-03 8.7e-04 3.5e-03
2 Brain mRNA stability Prr13 0.09 0.08 1.3e-04 0.05 0.04 0.04 0.04 1.6e-05 8.8e-05 2.2e-04 7.2e-05
3 Liver mRNA stability Prr13 0.03 0.02 7.1e-05 0.03 0.04 0.03 0.03 3.0e-04 6.4e-05 1.7e-04 4.5e-04
4 Liver gene expression Prr13 0.31 0.09 0.0e+00 0.34 0.35 0.34 0.34 3.2e-38 3.2e-40 4.0e-39 1.1e-38
5 pVTA gene expression Prr13 0.13 0.02 0.0e+00 0.4 0.42 0.42 0.42 6.0e-34 1.6e-36 1.6e-36 2.4e-36
6 BLA gene expression Prr13 0.41 0.07 0.0e+00 0.47 0.47 0.47 0.48 1.6e-27 1.2e-27 6.4e-28 1.8e-28
7 Adipose mRNA stability Prr13 0.1 0.06 3.6e-09 0.07 0.07 0.07 0.07 1.7e-08 1.3e-08 3.3e-08 1.6e-08
8 Eye gene expression Prr13 0.55 0.17 1.4e-04 0.27 0.22 0.28 0.31 5.1e-05 3.0e-04 2.8e-05 1.2e-05
9 IC gene expression Prr13 0.16 0.03 1.7e-16 0.32 0.37 0.35 0.34 6.5e-14 1.7e-16 2.2e-15 6.0e-15
10 OFC gene expression Prr13 0.44 0.16 3.7e-05 0.19 0.18 0.18 0.18 2.6e-05 3.9e-05 3.9e-05 3.9e-05
11 Brain gene expression Prr13 0.61 0.12 0.0e+00 0.57 0.58 0.57 0.58 5.8e-65 1.8e-65 6.1e-65 3.3e-65
12 Adipose gene expression Prr13 0.37 0.17 0.0e+00 0.33 0.33 0.32 0.32 1.7e-37 2.3e-37 6.4e-37 1.1e-36
13 PL gene expression Prr13 0.34 0.04 0.0e+00 0.47 0.46 0.47 0.47 2.4e-57 1.5e-55 7.6e-57 8.3e-58
14 LHb gene expression Prr13 0.37 0.16 4.3e-04 0.18 0.12 0.17 0.18 4.2e-05 9.6e-04 6.5e-05 5.2e-05
15 NAcc gene expression Prr13 0.08 0.02 0.0e+00 0.27 0.23 0.26 0.26 9.8e-41 4.8e-35 4.4e-39 5.4e-40

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.40.72.11.4-1.4-1.3-0.7-0.7-0.7-0.6-0.8-0.8-0.5-0.4-0.4-0.4-0.3-0.4
Area under the delay curve0.91.01.60.8-1.1-0.8-1.0-1.0-1.1-0.8-1.1-0.7-1.0-0.9-1.0-1.2-1.1-1.3
BMI with tail1.44.79.63.1-2.6-2.6-2.3-2.1-2.2-2.1-2.3-2.1-1.6-1.9-1.8-1.6-2.0-1.5
BMI without tail0.61.73.81.8-1.9-1.6-1.4-1.3-1.1-1.3-1.3-1.3-1.0-1.3-1.2-0.8-1.1-0.8
Body weight0.41.83.41.6-1.8-1.6-1.4-1.3-1.2-1.2-1.5-1.2-1.1-1.3-1.2-1.1-1.2-1.0
Weight adjusted by age0.20.20.9-0.90.90.80.30.40.50.30.30.50.30.10.10.30.00.3
Bone surface1.32.45.72.2-2.4-2.1-1.5-1.4-1.5-1.3-1.7-1.5-1.2-1.1-1.2-1.2-1.1-1.2
Bone volume1.12.05.02.2-2.2-2.0-1.3-1.3-1.4-1.2-1.4-1.4-1.0-0.9-0.9-1.0-0.8-0.9
Breakpoint value in progressive ratio session1.01.22.71.6-1.4-1.1-1.2-1.2-1.3-1.0-1.2-0.9-0.4-1.0-1.0-1.0-0.8-1.0
Number of licking bursts0.50.71.4-0.10.10.60.80.90.70.71.20.71.10.91.11.01.01.1
Context. condit. distance diff. score0.10.10.40.6-0.2-0.30.20.20.00.10.2-0.00.50.50.30.40.30.4
Locomotion velocity, session 16.87.49.7-3.12.52.72.92.82.92.82.92.62.62.52.52.62.62.5
Locomotion distance, session 14.45.56.8-2.42.12.52.52.42.42.32.62.32.42.22.32.32.32.3
Locomotion velocity, session 25.15.97.5-2.51.62.32.62.62.72.72.42.62.52.32.32.42.32.4
Locomotion distance, session 23.95.56.5-2.42.12.52.42.42.42.32.52.42.42.32.32.32.22.3
Locomotion velocity, session 34.55.26.4-2.51.62.22.42.42.52.52.22.42.22.12.12.32.32.2
Locomotion distance, session 35.05.56.6-2.11.52.02.52.52.52.62.32.42.42.42.42.42.42.4
Stereotopy head waving bouts, day 31.92.22.71.6-1.4-1.5-1.5-1.6-1.6-1.6-1.5-1.5-1.3-1.4-1.4-1.4-1.4-1.4
Stereotopy head waving duration, day 30.60.71.00.6-0.8-0.8-0.8-0.9-0.8-0.8-1.0-0.8-0.8-0.9-1.0-0.9-0.9-0.9
Locomotion velocity, session 70.20.20.7-0.70.80.50.50.40.40.30.40.20.20.40.20.30.30.3
Locomotion distance, session 71.51.95.0-2.21.41.61.51.41.61.41.31.31.01.21.01.00.81.0
Stereotopy head waving bouts, day 73.13.54.62.0-1.3-1.9-1.9-2.0-2.1-2.2-1.8-2.1-1.8-1.8-1.8-1.8-1.6-1.8
Stereotopy head waving duration, day 72.83.44.11.9-1.6-1.9-1.9-2.0-2.0-2.0-1.8-2.0-1.8-1.8-1.8-1.8-1.6-1.8
Locomotion velocity, session 80.10.10.2-0.20.10.10.50.40.40.40.40.20.50.50.30.40.40.4
Locomotion distance, session 84.26.17.6-1.91.92.22.72.62.52.52.62.32.82.82.52.62.42.6
Degree of sensitization distance1.11.12.20.3-0.2-0.6-1.0-1.1-1.0-1.1-1.0-1.1-1.2-1.1-1.3-1.3-1.5-1.3
Degree of sensitization stereotypy2.12.33.11.6-1.0-1.6-1.5-1.6-1.7-1.7-1.4-1.8-1.5-1.5-1.4-1.5-1.2-1.4
Conditioned locomotion2.42.73.8-1.01.21.41.71.71.51.61.71.61.91.81.81.81.91.8
Cocaine response after cond. corrected0.70.81.3-1.01.01.10.90.90.90.81.10.90.90.80.90.80.80.8
Cocaine response after cond. not corrected0.70.81.5-1.01.21.10.90.90.80.81.00.80.80.90.90.80.80.8
Cocaine response before conditioning0.10.10.2-0.30.3-0.1-0.2-0.3-0.1-0.2-0.4-0.2-0.5-0.3-0.4-0.3-0.3-0.4
Saline control response0.30.40.9-0.20.80.60.50.60.40.40.60.50.60.60.70.71.00.7
Bone: connectivity density0.00.00.10.4-0.2-0.3-0.1-0.0-0.10.0-0.2-0.00.00.10.20.10.20.1
Bone: cortical apparent density0.10.10.8-0.50.90.60.10.1-0.0-0.20.4-0.0-0.00.00.1-0.00.00.0
Bone: cortical area0.60.92.41.6-1.3-1.1-1.0-0.9-1.0-0.9-1.1-0.8-0.7-0.7-0.7-0.7-0.8-0.7
Bone: cortical porosity0.30.30.8-0.90.50.50.60.50.70.70.30.60.40.50.40.40.40.4
Bone: cortical porosity0.50.60.8-0.90.80.70.80.80.90.90.60.90.70.80.70.70.60.7
Bone: cortical thickness0.30.40.60.4-0.5-0.5-0.6-0.6-0.6-0.7-0.8-0.6-0.8-0.6-0.8-0.7-0.8-0.7
Bone: cortical thickness1.21.53.0-1.71.41.51.21.21.31.30.91.41.01.10.81.00.80.9
Bone: cortical tissue density0.10.20.9-0.61.00.80.30.20.2-0.00.60.10.10.20.20.20.20.2
Condit. Reinf. active minus inactive responses0.91.01.5-0.91.11.10.91.01.00.91.11.00.90.91.01.01.21.0
Condit. Reinf. active-inactive response ratio0.60.70.8-0.80.90.90.70.90.80.80.80.90.70.70.80.80.90.8
Condit. Reinf. active responses2.43.03.7-1.61.71.81.71.81.71.71.81.71.71.71.71.81.91.7
Condit. Reinf. inactive responses2.22.73.0-1.71.61.71.71.71.71.61.71.61.61.71.51.61.71.6
Incentive salience index mean0.60.71.2-0.40.80.70.80.80.70.70.90.70.90.90.90.91.10.9
Condit. Reinf. lever presses0.10.10.30.4-0.0-0.00.20.2-0.0-0.00.4-0.00.40.40.40.40.50.4
Condit. Reinf. active minus inactive responses1.31.72.21.0-0.7-1.1-1.3-1.4-1.4-1.4-1.3-1.3-1.3-1.3-1.5-1.4-1.4-1.4
Condit. Reinf. active-inactive response ratio0.60.70.80.7-0.5-0.7-0.8-0.9-0.9-0.9-0.9-0.8-0.8-0.8-0.9-0.9-0.9-0.9
Condit. Reinf. active responses1.62.32.91.1-0.7-1.2-1.5-1.6-1.6-1.7-1.5-1.6-1.6-1.6-1.7-1.6-1.5-1.6
Condit. Reinf. inactive responses0.10.10.20.10.2-0.1-0.3-0.4-0.3-0.5-0.2-0.4-0.4-0.3-0.4-0.3-0.2-0.3
Condit. Reinf. lever presses0.10.10.5-0.50.70.4-0.1-0.1-0.0-0.1-0.20.1-0.3-0.2-0.3-0.2-0.2-0.2
Condit. Reinf. lever reinforcers received0.71.01.40.6-0.2-0.6-1.0-1.1-1.1-1.1-1.0-1.0-1.1-1.1-1.2-1.1-1.0-1.1
Conditioned reinforcement - actives0.91.63.0-0.1-0.1-0.7-1.0-1.2-1.0-1.3-1.0-1.3-1.5-1.3-1.6-1.6-1.7-1.6
Conditioned reinforcement - inactives0.20.31.3-1.01.10.3-0.0-0.2-0.1-0.4-0.2-0.4-0.6-0.1-0.6-0.4-0.5-0.5
Conditioned locomotion1.82.34.40.2-0.8-1.0-1.2-1.5-1.4-1.4-1.4-1.5-1.8-1.4-1.8-2.0-1.9-2.1
Patch foraging indifference point 0 sec1.22.23.0-1.21.51.51.51.51.41.31.71.31.61.51.51.51.51.5
Patch foraging indifference point AUC0.40.51.2-0.61.10.80.70.70.60.41.00.40.70.60.70.70.80.7
Delay disc. indifference point, 0s delay0.10.10.3-0.3-0.30.0-0.3-0.3-0.2-0.1-0.4-0.1-0.5-0.5-0.4-0.6-0.5-0.6
Delay disc. indifference point, 16s delay0.30.40.50.7-0.3-0.5-0.6-0.6-0.7-0.6-0.7-0.5-0.6-0.5-0.6-0.6-0.6-0.6
Delay disc. indifference point, 2s delay6.16.87.72.4-2.2-2.4-2.7-2.7-2.7-2.8-2.5-2.7-2.6-2.7-2.7-2.7-2.7-2.7
Delay disc. indifference point, 24s delay0.20.30.40.5-0.6-0.4-0.5-0.5-0.7-0.4-0.4-0.3-0.4-0.5-0.3-0.6-0.4-0.6
Delay disc. indifference point, 4s delay1.11.21.51.0-1.2-0.9-1.1-1.1-1.1-1.0-1.2-0.8-1.0-1.0-1.1-1.2-1.2-1.2
Delay disc. indifference point, 8s delay0.10.10.60.2-0.8-0.2-0.2-0.3-0.3-0.1-0.4-0.1-0.4-0.2-0.2-0.4-0.4-0.5
Indifference point function ln k0.40.82.91.1-1.7-1.1-0.9-0.7-0.7-0.4-1.1-0.4-0.5-0.7-0.7-0.7-0.7-0.7
Indifference point function log k0.40.82.91.1-1.7-1.1-0.9-0.7-0.7-0.4-1.1-0.4-0.5-0.7-0.7-0.7-0.7-0.7
Patch foraging total patch changes 0 sec1.83.44.3-1.61.71.81.91.91.81.82.11.72.01.81.81.91.91.9
Patch foraging total patch changes 12 sec1.62.14.3-1.42.11.71.41.41.31.01.71.11.41.31.31.41.41.4
Patch foraging total patch changes 18 sec2.53.85.7-1.52.31.92.01.91.81.62.41.42.12.02.02.02.12.0
Patch foraging total patch changes 24 sec0.71.22.5-0.41.11.01.11.10.90.81.60.71.31.11.41.21.31.3
Patch foraging total patch changes 6 sec0.40.71.6-1.31.11.00.90.70.80.51.20.40.60.50.50.60.60.6
Patch foraging time to switch 0 sec0.40.81.50.0-0.2-0.5-0.8-0.9-0.8-0.9-0.9-0.9-1.1-0.9-1.1-1.1-1.2-1.1
Patch foraging water rate 0 sec0.20.30.80.3-0.00.20.40.60.40.50.60.60.80.50.70.80.90.8
Patch foraging water rate 12 sec0.40.91.4-0.30.20.70.81.00.91.10.91.11.10.91.21.21.21.1
Patch foraging water rate 18 sec0.00.00.10.00.30.20.10.10.10.10.10.20.20.10.10.20.10.2
Patch foraging water rate 24 sec0.10.20.80.9-0.6-0.5-0.5-0.4-0.5-0.4-0.3-0.4-0.1-0.4-0.2-0.2-0.1-0.2
Patch foraging water rate 6 sec0.50.81.60.9-0.10.10.60.80.40.80.50.81.31.11.21.11.11.2
Seeking ratio, delayed vs. immediate footshock0.10.20.6-0.2-0.10.1-0.4-0.2-0.1-0.3-0.60.0-0.8-0.4-0.7-0.2-0.6-0.2
Distance traveled before self-admin0.40.51.00.2-0.5-0.6-0.6-0.7-0.7-0.6-0.8-0.6-0.6-0.6-0.9-1.0-1.0-1.0
Distance traveled after self-admin0.40.51.10.10.0-0.2-0.6-0.6-0.5-0.5-1.0-0.3-0.9-0.6-1.0-0.9-0.9-0.9
Extensor digitorum longus weight8.533.335.55.4-5.9-5.8-5.9-6.0-5.8-5.8-5.7-5.7-5.7-5.9-5.8-5.7-5.6-5.7
Bone: elastic displacement0.60.73.7-1.90.61.20.70.71.10.90.61.10.20.30.20.40.30.3
Bone: elastic work0.30.42.5-1.6-0.00.80.40.40.80.70.10.8-0.1-0.0-0.10.0-0.1-0.0
Bone: endosteal estimation0.71.65.72.4-2.3-1.8-1.2-1.0-1.2-0.9-1.2-1.0-0.5-0.7-0.6-0.6-0.5-0.6
Bone: endosteal perimeter0.81.76.02.5-2.3-1.8-1.3-1.1-1.3-1.0-1.3-1.0-0.6-0.8-0.7-0.8-0.7-0.7
Epididymis fat weight1.13.66.3-2.01.62.01.72.02.12.31.52.51.91.62.01.81.81.7
Delta time in closed arm before/after self-admin0.30.30.80.9-0.4-0.6-0.7-0.4-0.7-0.6-0.7-0.5-0.7-0.6-0.4-0.3-0.4-0.3
Delta time in open arm before/after self-admin2.62.64.8-2.21.71.81.81.61.61.81.41.71.71.61.41.21.31.1
Diff in mean of infusions in LGA sessions0.00.10.10.2-0.1-0.3-0.3-0.2-0.2-0.3-0.2-0.3-0.3-0.2-0.2-0.2-0.1-0.2
Delay discount exponential model param1.31.52.2-1.01.31.01.21.31.31.01.31.01.21.21.21.51.41.5
Extinction: sum of active levers before priming0.90.94.11.8-2.0-1.4-1.0-0.7-0.6-0.7-0.8-0.80.2-0.8-0.5-0.2-0.4-0.2
Active lever presses in extinction session 60.20.21.00.9-1.0-0.3-0.3-0.2-0.4-0.1-0.3-0.00.2-0.1-0.1-0.1-0.1-0.1
Bone: final force0.81.34.41.8-2.1-1.6-1.1-0.9-1.0-0.7-1.2-0.9-0.7-0.8-0.7-0.7-0.8-0.7
Bone: final moment1.11.75.72.0-2.4-1.8-1.3-1.1-1.1-0.9-1.4-1.0-0.9-1.0-0.9-0.9-1.0-0.9
Food consumed during 24 hour testing period0.60.81.8-0.00.20.40.80.90.80.90.80.81.11.11.11.21.31.2
Glucose0.10.21.0-1.00.20.50.40.30.40.40.40.30.20.20.20.00.2-0.0
Heart weight0.30.40.80.40.20.40.50.70.30.70.50.80.90.90.90.70.90.7
Delay discount hyperbolic model param1.71.92.7-1.11.41.11.41.41.41.21.51.11.31.41.41.61.51.6
Intermittent access intake day 1-15 change0.00.00.1-0.0-0.20.20.20.20.10.30.20.30.10.20.20.30.20.3
Intermittent access intake escalation0.00.00.1-0.1-0.10.20.20.20.10.30.20.40.20.20.20.30.20.3
Intermittent access intake escalation 20.10.10.2-0.30.30.30.30.30.30.40.20.40.40.30.30.30.30.3
Intermitt. access day 1 inactive lever presses0.51.93.11.00.0-1.3-1.4-1.4-1.3-1.8-1.5-1.7-1.5-1.4-1.6-1.2-1.4-1.1
Intermitt. access day 15 inactive lever presses0.10.30.8-0.10.2-0.3-0.5-0.4-0.3-0.5-0.7-0.5-0.9-0.5-0.7-0.4-0.6-0.4
Intermitt. access escalation Index2.53.54.91.3-1.3-1.8-1.8-1.9-1.8-2.1-1.6-2.2-2.1-2.0-2.0-1.9-2.0-1.9
Intermittent access day 1 total infusions0.20.30.6-0.20.6-0.0-0.4-0.5-0.6-0.7-0.3-0.6-0.5-0.4-0.6-0.8-0.7-0.8
Intermittent access day 15 total infusions0.10.20.6-0.50.30.1-0.2-0.5-0.5-0.4-0.0-0.5-0.5-0.3-0.5-0.8-0.6-0.8
Intermittent access terminal intake (last 3 days)0.71.01.70.00.1-0.4-0.8-1.1-1.1-1.1-0.7-1.1-1.2-0.9-1.1-1.3-1.2-1.3
Intermittent access total infusions0.91.12.00.2-0.0-0.5-0.9-1.2-1.2-1.3-0.7-1.3-1.0-0.9-1.1-1.4-1.3-1.4
Intermittent access day 1 locomotion0.50.61.20.30.1-0.5-0.7-0.7-0.9-0.9-0.7-0.9-0.5-0.7-1.0-1.0-1.1-0.9
Intermittent access day 15 total locomotion0.00.00.1-0.1-0.2-0.1-0.0-0.1-0.00.1-0.30.0-0.20.0-0.1-0.1-0.2-0.1
Intermittent access total locomotion0.50.51.00.2-0.1-0.6-0.7-0.8-0.7-0.9-0.7-0.9-0.8-0.7-0.9-0.8-1.0-0.7
Intermittent access standard deviation0.30.61.1-1.00.71.00.90.60.60.90.70.80.81.00.70.30.50.3
Left kidney weight0.00.10.3-0.10.00.20.30.40.30.40.10.40.60.40.30.30.10.3
Right kidney weight0.00.10.50.5-0.7-0.7-0.3-0.20.0-0.2-0.6-0.30.0-0.3-0.40.1-0.30.1
Cocaine induced anxiety1.21.73.00.9-1.7-1.4-1.3-1.3-1.1-1.1-1.3-1.2-1.4-1.5-1.4-1.3-1.3-1.4
Post-drug Anxiety0.50.51.11.1-1.1-0.9-0.8-0.7-0.7-0.5-0.8-0.5-0.6-0.7-0.6-0.4-0.4-0.4
Baseline Anxiety1.71.92.8-0.41.31.21.31.41.01.41.31.51.61.71.61.51.71.6
Tail length0.20.71.9-1.40.71.00.90.81.10.90.90.80.60.70.50.80.70.7
Length with tail0.00.10.6-0.80.20.40.30.30.50.40.10.50.20.1-0.00.20.00.1
Length without tail0.20.71.40.5-0.8-0.7-0.9-0.8-0.8-0.6-1.2-0.5-0.6-0.9-1.0-1.0-1.1-1.0
Times rat made contact with spout0.30.40.70.1-0.10.10.50.60.60.70.50.60.80.60.80.80.80.8
Lifetime Intake0.91.11.60.30.1-0.6-0.9-1.1-1.2-1.3-0.8-1.3-1.1-1.0-1.1-1.3-1.2-1.3
Liver weight, left2.84.78.32.5-2.9-2.6-2.3-2.1-2.0-1.8-2.5-1.9-1.8-2.1-1.9-1.9-2.0-2.0
Liver weight, right0.10.20.40.3-0.6-0.5-0.5-0.5-0.4-0.2-0.7-0.3-0.4-0.5-0.4-0.6-0.6-0.6
Locomotor activity0.10.20.4-0.3-0.2-0.2-0.2-0.4-0.1-0.3-0.4-0.3-0.6-0.4-0.5-0.5-0.7-0.5
Locomotor testing distance0.00.10.3-0.6-0.10.10.0-0.10.10.0-0.1-0.1-0.4-0.2-0.4-0.3-0.3-0.3
Locomotor testing rearing0.00.10.3-0.5-0.30.30.30.30.50.50.30.40.10.10.20.20.20.2
Locomotion in novel chamber5.16.59.52.3-2.9-2.6-2.7-2.5-2.1-2.5-2.6-2.4-3.1-2.8-2.5-2.2-2.5-2.1
Locomotion in novel chamber post-restriction1.01.63.71.0-0.8-1.2-1.3-1.1-1.0-1.6-1.1-1.5-1.9-1.4-1.5-0.9-1.2-0.8
Fecal boli incidents, locomotor time 12.43.44.1-1.91.52.02.01.81.82.01.92.01.92.01.81.61.81.6
Change in fecal boli incidents, locomotor task0.70.71.00.8-0.8-1.0-0.9-0.7-0.7-0.9-0.8-0.9-0.9-0.9-0.9-0.7-0.9-0.7
Time >=10cm from walls, locomotor time 10.50.60.9-0.60.50.80.70.90.70.80.60.90.70.80.80.80.70.8
Bouts of movement, locomotor time 10.91.11.9-1.21.41.11.11.00.90.91.10.90.91.11.00.81.00.8
Total resting periods, locomotor time 12.22.43.3-1.81.81.71.61.61.51.51.61.51.41.51.41.41.51.4
Rest time, locomotor task time 10.40.51.1-1.00.50.80.80.80.70.70.90.70.60.60.70.60.70.6
Distance moved, locomotor task time 10.50.81.31.0-0.4-0.7-1.1-0.9-0.9-1.1-0.9-0.9-1.1-1.1-0.9-0.7-0.8-0.6
Vertical activity count, locomotor time 11.12.63.41.4-0.9-1.4-1.6-1.7-1.7-1.8-1.6-1.8-1.8-1.5-1.6-1.7-1.7-1.6
Time >=10cm from walls, locomotor time 20.00.00.4-0.2-0.10.1-0.1-0.00.2-0.1-0.00.0-0.6-0.2-0.10.1-0.20.1
Bouts of movement, locomotor time 21.22.02.81.7-1.3-1.5-1.4-1.4-1.5-1.5-1.3-1.5-1.4-1.3-1.3-1.3-1.2-1.2
Total resting periods, locomotor time 21.22.13.11.8-1.3-1.5-1.5-1.5-1.6-1.6-1.3-1.6-1.4-1.3-1.3-1.4-1.3-1.3
Rest time, locomotor task time 20.60.71.2-0.60.80.81.00.80.70.81.10.60.91.01.00.80.90.8
Distance moved, locomotor task time 20.10.10.6-0.20.0-0.1-0.4-0.2-0.1-0.3-0.4-0.1-0.8-0.6-0.4-0.2-0.3-0.2
Vertical activity count, locomotor time 21.01.43.00.5-0.9-0.9-1.2-1.3-1.1-1.1-1.1-1.0-1.7-1.4-1.2-1.3-1.3-1.3
Light reinforcement 11.02.43.6-1.01.61.51.61.51.31.21.91.21.71.71.61.61.81.7
Light reinforcement 20.91.42.8-1.51.71.31.31.11.21.01.30.80.91.11.01.00.91.0
Bone: marrow area0.71.55.62.4-2.3-1.8-1.2-1.0-1.2-0.9-1.2-1.0-0.5-0.7-0.6-0.6-0.6-0.6
Bone: maximum diameter0.50.93.11.8-1.3-1.2-1.0-0.9-1.1-0.9-0.9-0.9-0.5-0.6-0.6-0.6-0.6-0.6
Bone: maximum force1.11.95.51.9-2.3-1.8-1.3-1.2-1.3-1.1-1.3-1.3-1.0-1.0-1.0-1.0-1.0-1.0
Bone: maximum moment1.42.46.72.1-2.6-2.0-1.5-1.4-1.4-1.2-1.5-1.4-1.2-1.2-1.2-1.2-1.2-1.2
Mean time between licks in bursts0.10.11.3-1.10.30.20.30.10.50.20.2-0.0-0.2-0.1-0.2-0.1-0.1-0.1
Mean num. licks in bursts0.10.20.6-0.1-0.1-0.4-0.4-0.4-0.2-0.1-0.8-0.2-0.6-0.4-0.6-0.5-0.5-0.5
Cd content in liver0.30.30.8-0.4-0.0-0.1-0.5-0.6-0.3-0.5-0.5-0.4-0.9-0.7-0.7-0.8-0.7-0.8
Co content in liver0.30.41.30.7-1.1-0.7-0.6-0.6-0.6-0.5-0.5-0.5-0.5-0.6-0.5-0.6-0.5-0.6
Cu content in liver3.54.29.43.1-2.5-2.4-2.2-2.0-2.2-1.9-2.2-1.8-1.5-1.7-1.7-1.7-1.6-1.6
Fe content in liver0.10.10.60.2-0.8-0.2-0.4-0.3-0.2-0.2-0.2-0.2-0.4-0.5-0.2-0.3-0.3-0.3
K content in liver0.10.11.00.8-1.0-0.5-0.2-0.1-0.2-0.00.0-0.20.2-0.00.20.10.20.2
Mg content in liver0.10.10.80.6-0.9-0.5-0.1-0.0-0.10.0-0.0-0.10.20.00.10.10.20.1
Mn content in liver0.00.00.1-0.30.0-0.20.10.00.10.00.0-0.3-0.0-0.0-0.1-0.1-0.2-0.1
Na content in liver0.91.01.91.2-1.4-1.3-0.9-0.9-0.9-0.9-1.0-1.1-0.8-0.8-0.9-0.8-0.9-0.8
Rb content in liver0.70.82.61.3-1.6-0.9-0.9-0.8-0.9-0.8-0.8-0.7-0.6-0.8-0.6-0.7-0.6-0.7
Se content in liver0.30.40.6-0.80.50.70.70.60.70.70.60.70.60.60.60.50.40.5
Sr content in liver0.60.50.9-0.60.40.40.80.80.80.90.70.60.70.70.90.80.70.8
Zn content in liver1.92.22.9-0.71.21.31.41.51.31.41.41.51.71.61.71.61.71.6
Bone: minimum diameter1.12.14.42.1-1.8-1.8-1.5-1.4-1.5-1.3-1.6-1.3-1.1-1.2-1.1-1.1-1.1-1.1
Time in familiar zone, hab. session 10.10.10.5-0.70.20.40.30.30.40.40.10.40.00.20.10.10.20.1
Time in novel zone, hab. session 10.70.71.31.1-0.4-0.8-0.9-0.9-1.1-1.1-0.6-1.0-0.6-0.8-0.7-0.8-0.8-0.7
Total zone transitions, hab. session 10.30.51.2-0.41.10.70.70.60.40.30.90.30.70.80.70.60.60.7
Total locomotion distance, hab. session 13.34.75.6-1.72.32.12.22.22.02.12.22.02.42.32.22.22.12.3
Locomotion velocity, hab. session 12.83.94.4-1.61.91.92.12.11.92.02.01.92.12.12.02.01.92.0
Time in familiar zone, hab. session 21.11.22.30.7-1.5-1.3-1.0-1.0-0.8-0.8-1.2-1.0-1.3-1.1-1.2-1.0-0.9-1.1
Time in novel zone, hab. session 20.20.20.40.00.50.50.30.40.20.20.60.40.60.40.60.40.50.5
Total zone transitions, hab. session 21.62.12.5-1.21.21.41.51.51.41.41.51.41.51.61.51.51.41.5
Total locomotion distance, hab. session 25.67.39.2-1.82.22.52.72.82.52.72.82.73.02.92.92.92.82.9
Locomotion velocity, hab. session 25.77.69.5-1.82.22.62.82.92.62.82.82.83.13.03.03.02.83.0
Novel to familiar place preference ratio0.00.10.20.50.30.1-0.00.1-0.10.00.10.10.40.10.30.20.20.2
Novelty place preference0.00.00.20.40.10.10.00.1-0.10.00.10.10.40.10.30.20.20.2
Time in novel zone, NPP test0.00.00.30.50.1-0.1-0.10.0-0.2-0.10.00.00.2-0.00.20.10.10.1
Total zone transitions, NPP test3.95.67.2-2.32.72.52.52.42.32.12.62.12.42.42.32.32.22.3
Total locomotion distance, NPP test9.212.613.7-3.13.43.63.73.73.53.53.73.53.73.73.63.63.53.6
Locomotion velocity, NPP test10.114.315.3-3.23.63.73.93.93.73.73.93.73.93.93.93.93.83.9
Intraocular pressure0.30.40.8-0.30.0-0.2-0.5-0.7-0.5-0.7-0.5-0.6-0.9-0.8-0.9-0.8-0.9-0.8
Delta distance traveled before/after self-admin1.92.02.9-0.81.41.41.31.51.41.51.11.71.31.51.51.61.51.6
Delta ambulatory time before/after self-admin1.21.52.2-0.51.21.21.11.21.21.30.81.51.21.31.21.31.41.3
Parametrial fat weight0.40.91.3-0.81.01.11.01.00.81.01.11.10.70.91.00.81.10.8
Pavlov. Cond. lever latency0.30.42.3-1.50.90.80.40.40.70.70.10.7-0.00.10.10.1-0.10.1
Pavlov. Cond. magazine entry latency3.34.25.01.8-1.9-2.0-2.1-2.2-2.1-2.2-1.8-2.2-2.2-2.1-2.0-2.1-2.0-2.1
Pavlov. Cond. change in total contacts2.62.84.82.2-1.6-1.8-1.7-1.7-1.9-1.9-1.5-1.8-1.4-1.5-1.5-1.5-1.4-1.5
Pavlov. Cond. index score3.03.86.12.5-2.2-2.1-2.0-2.0-2.2-2.2-1.7-2.2-1.7-1.8-1.7-1.8-1.6-1.7
Pavlov. Cond. latency score2.53.16.32.5-2.1-1.9-1.8-1.8-2.0-2.0-1.4-1.9-1.4-1.5-1.4-1.5-1.3-1.4
Pavlov. Cond. lever contacts0.50.62.51.6-1.1-1.0-0.7-0.7-0.9-0.9-0.4-1.0-0.3-0.4-0.4-0.4-0.2-0.4
Pavlov. Cond. magazine entry number2.22.83.4-1.51.51.51.71.81.81.81.51.81.71.71.61.71.61.7
Pavlov. Cond. intertrial magazine entries1.92.34.7-2.02.21.81.51.51.51.51.41.51.31.31.21.21.11.2
Pavlov. Cond. lever-magazine prob. diff.3.24.05.92.4-2.2-2.1-2.0-2.1-2.2-2.2-1.7-2.2-1.7-1.8-1.8-1.8-1.7-1.8
Pavlov. Cond. response bias1.41.72.31.3-1.3-1.3-1.3-1.4-1.4-1.5-1.1-1.5-1.3-1.3-1.3-1.3-1.1-1.3
Pavlov. Cond. lever latency0.81.12.41.4-1.5-1.4-1.0-1.0-1.0-1.0-0.9-1.2-0.8-0.9-0.7-0.9-0.9-0.8
Pavlov. Cond. magazine entry latency2.02.45.8-2.41.91.91.61.51.71.61.41.71.11.21.11.21.21.2
Pavlov. Cond. change in total contacts0.30.50.80.60.2-0.5-0.7-0.7-0.8-0.9-0.6-0.8-0.7-0.6-0.7-0.7-0.6-0.7
Pavlov. Cond. index score1.52.03.9-2.01.91.81.41.41.51.31.21.51.11.21.01.21.21.1
Pavlov. Cond. latency score1.72.34.0-2.02.01.81.51.51.51.41.41.61.21.31.21.31.31.3
Pavlov. Cond. lever contacts1.42.03.4-1.81.81.71.31.41.41.41.21.51.21.21.01.21.21.2
Pavlov. Cond. magazine entry number0.70.82.01.4-1.4-1.3-0.9-0.9-1.0-0.9-0.7-1.0-0.6-0.7-0.6-0.7-0.6-0.7
Pavlov. Cond. intertrial magazine entries0.30.40.7-0.50.10.50.60.70.70.80.50.80.70.60.50.70.70.7
Pavlov. Cond. lever-magazine prob. diff.0.91.22.9-1.71.71.51.11.11.11.00.91.10.70.90.70.80.90.8
Pavlov. Cond. response bias0.70.92.4-1.51.51.30.90.91.00.90.71.10.60.70.50.70.70.7
Time in closed arm before self-admin0.00.10.40.2-0.0-0.4-0.0-0.1-0.1-0.3-0.0-0.6-0.20.0-0.1-0.0-0.10.0
Time in closed arm after self-admin2.02.13.21.6-0.9-1.5-1.5-1.4-1.6-1.8-1.3-1.7-1.6-1.5-1.4-1.2-1.5-1.2
Time in open arm before self-admin3.13.44.11.6-1.7-1.6-2.0-1.9-1.8-2.0-1.9-1.8-2.0-2.0-2.0-1.8-1.9-1.8
Time in open arm after self-admin0.50.50.9-1.00.60.80.80.70.80.90.50.80.80.70.50.60.60.5
Bone: periosteal estimation1.22.57.62.8-2.6-2.1-1.6-1.4-1.6-1.3-1.6-1.3-0.9-1.0-0.9-1.0-0.9-1.0
Bone: periosteal perimeter1.72.96.62.6-2.4-2.0-1.8-1.6-1.8-1.5-1.8-1.4-1.2-1.4-1.3-1.4-1.3-1.3
Bone: post-yield work0.50.82.31.4-1.5-1.2-0.8-0.8-0.9-0.7-0.8-0.8-0.5-0.6-0.6-0.6-0.7-0.6
Progressive ratio test 1 active lever presses0.20.20.9-0.81.00.70.40.20.20.10.60.10.00.20.10.1-0.00.1
Progressive ratio test 1 breakpoint0.20.21.0-0.91.00.80.50.30.30.10.60.20.10.30.20.20.10.2
Progressive ratio test 1 inactive lever presses0.71.01.70.30.4-0.3-0.9-1.0-1.2-1.2-0.9-1.0-0.9-0.9-1.2-1.3-1.2-1.3
Progressive ratio test 2 active lever presses1.61.92.50.9-0.6-0.9-1.4-1.5-1.5-1.5-1.3-1.4-1.5-1.3-1.5-1.6-1.5-1.6
Progressive ratio test 2 breakpoint1.72.02.61.0-0.7-1.0-1.4-1.5-1.6-1.6-1.3-1.5-1.5-1.3-1.5-1.6-1.5-1.6
Progressive ratio test 2 inactive lever presses0.91.42.10.6-0.4-0.8-1.2-1.3-1.3-1.3-1.3-1.2-1.3-1.2-1.4-1.4-1.4-1.4
Incentive Sensitization - Responses1.42.02.61.5-1.3-1.3-1.5-1.5-1.6-1.4-1.4-1.3-1.5-1.2-1.3-1.5-1.3-1.5
Incentive Sensitization - Breakpoint1.82.43.11.7-1.4-1.4-1.6-1.6-1.8-1.5-1.5-1.5-1.7-1.3-1.4-1.6-1.4-1.6
Sum of active levers in priming session hrs 5-60.30.30.50.2-0.1-0.2-0.6-0.6-0.6-0.7-0.6-0.5-0.2-0.6-0.7-0.7-0.7-0.7
Progressive ratio0.20.40.80.1-0.3-0.2-0.6-0.6-0.6-0.6-0.6-0.4-0.3-0.8-0.8-0.8-0.9-0.8
Food seeking constrained by brief footshock0.10.10.30.60.60.3-0.10.1-0.4-0.30.1-0.00.40.20.10.10.20.1
Seeking ratio, punishment vs. effort0.00.10.40.20.60.10.10.20.1-0.10.1-0.1-0.00.30.20.30.40.3
Retroperitoneal fat weight1.25.17.7-2.82.52.42.32.32.52.42.22.31.52.12.12.12.02.0
Reaction time number correct0.00.10.5-0.3-0.7-0.1-0.1-0.10.10.3-0.30.3-0.0-0.3-0.4-0.2-0.4-0.3
Reaction time mean minus median0.00.10.4-0.40.70.1-0.0-0.2-0.2-0.3-0.2-0.3-0.3-0.1-0.4-0.3-0.4-0.3
Reaction time mean minus median AUC0.20.61.1-0.10.3-0.3-0.6-0.8-0.7-0.9-0.7-0.8-0.9-0.8-1.1-0.9-1.0-0.9
Reaction time num false alarms3.34.76.9-1.92.62.12.32.22.01.92.21.82.12.32.12.22.32.2
Reaction time num false alarms AUC2.13.26.4-1.92.51.91.91.71.71.51.91.41.61.91.61.71.81.7
Reaction time trials correct on left0.00.10.5-0.3-0.7-0.1-0.1-0.10.10.3-0.30.3-0.0-0.3-0.4-0.2-0.4-0.3
Reaction time trials on left0.00.10.4-0.4-0.6-0.0-0.00.00.20.3-0.30.30.1-0.2-0.3-0.1-0.3-0.2
Reaction time mean0.00.00.30.50.4-0.1-0.0-0.0-0.2-0.1-0.2-0.10.20.30.10.10.10.1
Reaction time mean AUC0.10.10.40.60.1-0.4-0.3-0.3-0.5-0.3-0.5-0.3-0.1-0.1-0.2-0.2-0.3-0.2
Median of all reaction times0.10.10.50.70.2-0.10.10.2-0.10.2-0.10.20.50.40.40.30.40.4
Reaction time omissions1.92.85.3-1.52.31.91.61.71.61.61.41.71.61.81.51.61.61.6
Reaction time false alarm rate1.52.05.4-1.12.31.41.51.31.10.91.60.81.31.61.41.41.61.5
Reaction time premature initiation rate0.20.20.9-0.50.90.50.50.50.40.40.40.40.30.60.50.40.30.4
Reaction time premature initiations0.10.10.4-0.60.40.30.40.30.40.50.10.40.20.30.20.20.00.2
Std. dev. reaction times0.00.10.4-0.10.70.0-0.1-0.2-0.3-0.3-0.2-0.3-0.2-0.1-0.3-0.3-0.4-0.3
Reaction time trials completed0.00.10.4-0.4-0.6-0.0-0.00.00.20.3-0.30.30.1-0.2-0.3-0.1-0.3-0.2
Reaction time trials AUC0.10.10.6-0.2-0.8-0.2-0.1-0.10.10.2-0.40.2-0.1-0.4-0.4-0.2-0.3-0.3
Run reversals in cocaine runway, females0.00.00.1-0.10.1-0.1-0.00.00.10.0-0.3-0.00.1-0.0-0.20.0-0.20.0
Run reversals in cocaine runway, males0.30.30.8-0.4-0.1-0.2-0.5-0.4-0.4-0.6-0.3-0.5-0.6-0.9-0.8-0.8-0.7-0.8
Latency to leave start box in cocaine runway0.10.10.50.5-0.3-0.4-0.4-0.2-0.4-0.4-0.3-0.5-0.7-0.4-0.3-0.1-0.1-0.0
Latency to leave start box in cocaine runway, F0.10.10.20.00.30.20.20.40.10.10.40.20.30.20.30.40.40.5
Latency to leave start box in cocaine runway, M1.21.13.01.0-1.0-1.2-1.0-1.0-0.9-1.0-1.1-1.1-1.7-0.9-0.9-0.8-0.8-0.8
Std. dev. time between licks in bursts1.01.41.9-1.40.61.11.31.31.41.31.21.21.21.01.01.11.11.1
Total sessions with >9 infusions0.40.51.10.50.1-0.4-0.7-0.7-0.8-1.0-0.6-0.9-0.9-0.6-0.8-0.6-0.7-0.6
Short access day 1 total inactive lever presses0.70.91.40.2-0.2-0.5-1.0-0.9-0.8-1.1-0.9-0.9-1.2-1.1-1.2-1.1-0.9-1.1
Short access day 10 total inactive lever presses0.40.91.60.8-0.0-0.8-1.1-1.0-0.8-1.1-1.3-1.0-0.9-1.0-1.2-0.7-1.0-0.6
Short access day 1 total infusions0.50.62.30.40.1-0.5-0.9-0.7-0.7-1.0-0.8-0.9-1.5-0.9-0.9-0.7-0.7-0.6
Short access day 10 total infusions0.30.40.70.10.5-0.1-0.4-0.5-0.8-0.8-0.4-0.8-0.6-0.5-0.7-0.9-0.7-0.9
Short access total infusions0.50.61.00.40.1-0.5-0.7-0.7-0.8-1.0-0.6-1.0-1.0-0.8-0.9-0.8-0.8-0.7
Short access day 1 locomotion0.30.30.50.5-0.1-0.5-0.5-0.6-0.7-0.7-0.5-0.7-0.6-0.5-0.6-0.7-0.5-0.7
Short access day 10 total locomotion0.00.00.20.50.2-0.2-0.1-0.0-0.2-0.3-0.2-0.3-0.00.1-0.10.1-0.20.1
Short access total locomotion0.10.10.30.30.2-0.1-0.3-0.3-0.5-0.6-0.3-0.5-0.3-0.3-0.5-0.3-0.5-0.3
One hour access (0.3 mA shock)3.84.45.22.0-1.9-2.0-2.1-2.2-2.3-2.2-2.1-2.1-2.1-2.0-2.1-2.2-2.2-2.1
Compulsive drug intake1.01.23.92.0-0.9-1.4-0.9-1.0-1.4-1.2-1.0-1.3-0.6-0.4-0.7-1.0-0.8-0.9
One hour access (shock baseline)1.92.94.40.9-1.3-1.2-1.9-1.8-1.6-1.7-1.7-1.5-1.9-2.1-2.0-1.8-2.0-1.8
Social response proportion0.40.51.7-1.31.21.00.70.60.70.70.40.80.30.60.40.40.30.3
Social responses1.31.72.3-1.51.41.51.41.31.31.31.31.31.21.31.21.21.31.2
Social time0.60.82.1-1.51.01.10.90.91.01.00.61.10.50.70.50.60.80.6
Soleus weight0.72.13.30.6-1.5-1.4-1.3-1.4-1.2-1.1-1.7-1.3-1.6-1.6-1.8-1.6-1.6-1.7
Bone: stiffness1.32.27.82.8-2.3-2.2-1.4-1.2-1.5-1.3-1.2-1.5-0.7-0.8-0.7-0.8-0.7-0.7
Tibialis anterior weight6.221.025.15.0-4.5-4.9-4.7-4.8-4.9-4.9-4.2-4.9-4.3-4.5-4.3-4.4-4.1-4.3
Time to tail flick, vehicle, before self-admin0.40.40.60.3-0.4-0.4-0.5-0.6-0.7-0.6-0.7-0.6-0.5-0.5-0.7-0.7-0.8-0.7
Time to tail flick, vehicle, after self-admin0.00.10.20.3-0.4-0.3-0.1-0.1-0.30.1-0.10.00.0-0.10.1-0.4-0.1-0.4
Time to tail flick, test, before self-admin0.20.21.2-0.91.10.50.40.20.30.10.20.1-0.10.2-0.10.1-0.10.1
Time to tail flick, test, after self-admin0.70.71.40.8-0.7-1.1-0.9-0.7-0.5-0.8-1.1-1.0-1.2-0.8-0.9-0.5-0.8-0.4
Delta time to tail flick, vehicle, before/after SA0.30.30.80.2-0.30.20.40.40.20.70.60.70.90.50.90.20.70.2
Delta time to tail flick, test, before/after SA0.20.20.90.9-0.7-0.7-0.4-0.1-0.1-0.3-0.5-0.3-0.4-0.2-0.00.20.00.2
Tibia length0.10.41.41.2-0.8-0.7-0.7-0.5-0.7-0.4-0.9-0.3-0.3-0.4-0.5-0.4-0.5-0.4
Ambulatory time before self-admin0.30.40.9-0.0-0.3-0.5-0.5-0.6-0.6-0.6-0.7-0.7-0.7-0.6-0.9-0.8-1.0-0.8
Ambulatory time after self-admin0.50.61.60.3-0.1-0.5-0.7-0.7-0.7-0.6-1.3-0.5-0.9-0.6-1.1-0.9-1.0-1.0
Bone: tissue strength2.12.12.81.4-1.7-1.5-1.5-1.5-1.4-1.5-1.3-1.5-1.4-1.5-1.4-1.3-1.3-1.3
Total heroin consumption0.80.93.01.6-1.7-1.1-0.9-1.0-1.1-0.6-1.0-0.6-0.1-0.6-0.5-0.9-0.6-0.9
Bone: trabecular number0.10.20.50.4-0.3-0.20.30.40.30.40.20.20.40.60.70.60.70.6
Bone: trabecular spacing0.40.60.90.7-0.2-0.5-0.7-0.8-0.9-0.9-0.7-0.8-0.6-0.7-0.8-0.8-0.9-0.8
Bone: trabecular thickness0.20.20.6-0.10.30.20.40.40.40.30.50.30.40.50.50.50.70.5
Bone: trabecular tissue density0.10.10.30.50.30.10.10.0-0.3-0.30.4-0.30.30.30.30.20.30.3
Water consumed over 24 hours0.20.30.6-0.1-0.20.20.40.50.60.60.50.50.50.40.60.60.80.6
Number of responses in last shaping day1.51.74.4-2.11.61.61.21.11.51.31.21.30.81.01.01.01.00.9