Prr13

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Prr13 0.02 0.01 5.4e-04 0.02 0.03 0.02 0.02 1.3e-03 4.2e-04 1.8e-03 2.4e-03
2 Liver gene expression Prr13 0.54 0.01 0.0e+00 0.36 0.36 0.36 0.36 4.9e-41 1.9e-41 1.3e-41 1.9e-41
3 Brain mRNA stability Prr13 0.05 0.04 1.7e-04 0.03 0.04 0.03 0.03 4.7e-04 5.0e-05 6.7e-04 3.7e-04
4 Adipose gene expression Prr13 0.53 0.01 0.0e+00 0.31 0.31 0.31 0.31 4.9e-35 3.6e-35 2.6e-35 1.3e-34
5 Brain gene expression Prr13 0.67 0.08 0.0e+00 0.6 0.59 0.59 0.6 5.1e-69 3.0e-67 1.4e-67 9.2e-69
6 Adipose mRNA stability Prr13 0.1 0.06 3.8e-09 0.08 0.07 0.07 0.08 3.0e-09 1.1e-08 1.7e-08 7.3e-09
7 pVTA gene expression Prr13 0.47 0.06 0.0e+00 0.45 0.45 0.46 0.46 1.2e-21 2.7e-21 7.9e-22 6.9e-22
8 LHb gene expression Prr13 0.36 0.17 3.6e-04 0.18 0.13 0.18 0.18 4.6e-05 4.6e-04 4.1e-05 5.1e-05
9 OFC gene expression Prr13 0.29 0.15 6.7e-05 0.19 0.17 0.17 0.18 2.3e-05 6.4e-05 7.7e-05 5.0e-05
10 Eye gene expression Prr13 0.46 0.17 5.8e-04 0.27 0.14 0.23 0.25 4.7e-05 3.8e-03 1.8e-04 1.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.40.61.7-1.31.0-0.71.00.70.5-0.60.50.40.4
Area under the delay curve0.91.01.6-0.71.1-0.81.01.31.0-1.10.90.90.9
BMI with tail0.72.33.8-2.01.8-1.91.61.31.3-1.31.31.21.2
BMI without tail0.10.20.6-0.1-0.2-0.4-0.2-0.8-0.30.6-0.3-0.4-0.4
Body weight0.10.40.9-0.90.8-0.90.70.60.4-0.60.50.40.4
Weight adjusted by age0.20.30.60.8-0.60.4-0.7-0.5-0.50.5-0.4-0.4-0.4
Bone surface1.42.54.6-2.22.0-1.51.91.61.2-1.41.21.21.2
Bone volume0.91.63.7-1.91.6-1.31.61.30.8-1.10.90.80.8
Breakpoint value in progressive ratio session2.32.54.3-1.71.8-2.11.51.51.1-1.61.51.41.4
Number of licking bursts0.50.61.10.5-0.70.0-0.7-1.0-0.60.9-0.7-1.0-1.0
Context. condit. distance diff. score0.10.10.3-0.50.4-0.20.30.1-0.20.1-0.3-0.0-0.0
Locomotion velocity, session 17.17.68.82.8-3.02.7-2.9-3.0-2.52.8-2.6-2.7-2.7
Locomotion distance, session 14.55.86.32.5-2.52.2-2.4-2.4-2.42.4-2.5-2.4-2.4
Locomotion velocity, session 25.36.26.92.4-2.52.1-2.6-2.6-2.52.6-2.5-2.6-2.6
Locomotion distance, session 24.36.06.92.6-2.62.5-2.5-2.2-2.32.4-2.5-2.5-2.5
Locomotion velocity, session 34.55.35.92.4-2.22.2-2.4-2.1-2.42.2-2.4-2.3-2.3
Locomotion distance, session 35.15.57.22.1-2.02.2-2.2-2.3-2.72.5-2.7-2.4-2.4
Stereotopy head waving bouts, day 31.11.31.8-1.31.0-1.31.21.01.2-1.11.30.90.9
Stereotopy head waving duration, day 30.50.50.9-0.70.5-0.80.60.70.9-0.80.90.60.6
Locomotion velocity, session 70.20.20.70.6-0.50.8-0.3-0.2-0.10.3-0.2-0.1-0.1
Locomotion distance, session 71.31.63.11.7-1.31.8-1.3-0.9-1.11.1-1.2-1.1-1.1
Stereotopy head waving bouts, day 71.31.41.9-1.41.0-1.21.20.91.4-1.21.41.11.1
Stereotopy head waving duration, day 72.93.54.5-2.01.7-1.81.91.62.0-1.92.11.81.8
Locomotion velocity, session 80.00.00.00.2-0.20.1-0.2-0.2-0.20.2-0.2-0.2-0.2
Locomotion distance, session 83.45.17.02.0-2.02.3-2.0-2.0-2.52.4-2.6-2.3-2.3
Degree of sensitization distance1.21.21.9-0.60.8-0.71.01.21.4-1.31.31.21.2
Degree of sensitization stereotypy1.92.12.8-1.71.3-1.41.51.21.6-1.41.61.41.4
Conditioned locomotion1.72.02.71.2-1.31.3-1.3-1.3-1.61.4-1.5-1.6-1.6
Cocaine response after cond. corrected0.50.61.41.2-0.61.0-0.7-0.3-1.00.7-1.0-0.4-0.4
Cocaine response after cond. not corrected0.60.61.31.1-0.71.0-0.7-0.4-0.90.7-0.9-0.5-0.5
Cocaine response before conditioning0.00.00.1-0.1-0.10.10.1-0.00.4-0.10.40.20.2
Saline control response1.01.32.00.7-1.00.8-1.2-1.4-1.11.3-1.2-1.2-1.2
Bone: connectivity density0.00.10.1-0.40.40.10.40.30.0-0.20.10.30.3
Bone: cortical apparent density0.00.00.20.5-0.30.2-0.2-0.20.00.10.10.00.0
Bone: cortical area0.40.61.3-1.21.1-0.80.90.70.5-0.70.60.70.7
Bone: cortical porosity0.60.71.00.5-0.70.9-0.8-1.0-0.80.9-0.7-0.8-0.8
Bone: cortical porosity1.21.31.80.9-1.11.2-1.2-1.3-1.21.3-1.1-1.2-1.2
Bone: cortical thickness0.20.30.5-0.50.6-0.10.60.60.6-0.60.70.60.6
Bone: cortical thickness1.51.83.41.7-1.51.9-1.4-1.1-1.11.2-1.1-1.1-1.1
Bone: cortical tissue density0.10.10.40.6-0.50.4-0.3-0.3-0.10.3-0.1-0.1-0.1
Condit. Reinf. active minus inactive responses1.21.31.71.0-1.21.1-1.2-1.3-1.11.2-1.1-1.1-1.1
Condit. Reinf. active-inactive response ratio0.50.60.70.7-0.70.8-0.8-0.8-0.70.8-0.8-0.7-0.7
Condit. Reinf. active responses3.23.94.31.8-2.01.8-2.0-2.1-2.02.0-1.9-2.0-2.0
Condit. Reinf. inactive responses3.13.74.22.0-2.01.9-1.9-1.9-1.91.9-1.8-1.9-1.9
Incentive salience index mean0.91.11.70.8-1.10.9-1.1-1.3-1.11.2-1.0-1.1-1.1
Condit. Reinf. lever presses0.10.10.4-0.0-0.30.1-0.3-0.6-0.40.5-0.3-0.4-0.4
Condit. Reinf. active minus inactive responses1.82.33.6-1.21.6-1.31.51.91.3-1.71.41.51.5
Condit. Reinf. active-inactive response ratio1.41.52.6-1.01.4-1.01.21.61.0-1.41.01.31.3
Condit. Reinf. active responses1.42.02.7-1.31.4-1.31.41.61.3-1.61.41.31.3
Condit. Reinf. inactive responses0.00.00.2-0.0-0.30.0-0.1-0.5-0.00.10.0-0.2-0.2
Condit. Reinf. lever presses0.00.10.30.5-0.10.4-0.30.1-0.2-0.0-0.2-0.1-0.1
Condit. Reinf. lever reinforcers received0.81.11.7-0.81.0-0.91.01.30.9-1.31.01.01.0
Conditioned reinforcement - actives2.22.24.8-0.81.3-0.61.52.21.3-1.91.51.51.5
Conditioned reinforcement - inactives0.10.10.90.4-0.21.0-0.00.20.3-0.20.30.20.2
Conditioned locomotion1.92.33.6-1.01.4-0.51.61.91.5-1.81.61.61.6
Patch foraging indifference point 0 sec1.82.94.11.3-1.81.4-1.7-2.0-1.61.6-1.5-2.0-2.0
Patch foraging indifference point AUC0.80.91.20.9-1.10.8-1.0-1.0-1.10.9-0.9-0.9-0.9
Delay disc. indifference point, 0s delay0.20.20.5-0.00.3-0.30.30.60.7-0.60.50.50.5
Delay disc. indifference point, 16s delay0.50.50.8-0.60.8-0.50.80.90.9-0.80.70.60.6
Delay disc. indifference point, 2s delay5.66.27.5-2.42.4-2.52.52.42.7-2.52.62.52.5
Delay disc. indifference point, 24s delay0.50.50.9-0.50.8-0.70.70.90.5-0.70.50.70.7
Delay disc. indifference point, 4s delay1.11.21.6-0.91.2-1.11.11.31.0-1.21.01.11.1
Delay disc. indifference point, 8s delay0.10.10.3-0.30.5-0.20.50.60.5-0.40.20.30.3
Indifference point function ln k0.71.01.9-1.31.4-1.31.00.80.7-0.80.70.90.9
Indifference point function log k0.71.01.9-1.31.4-1.31.00.80.7-0.80.70.90.9
Patch foraging total patch changes 0 sec2.84.56.21.7-2.11.7-2.1-2.4-2.02.1-1.9-2.5-2.5
Patch foraging total patch changes 12 sec1.82.43.01.6-1.71.5-1.6-1.5-1.51.4-1.4-1.5-1.5
Patch foraging total patch changes 18 sec3.74.86.11.9-2.42.0-2.1-2.2-2.22.1-2.1-2.5-2.5
Patch foraging total patch changes 24 sec1.31.62.30.8-1.30.6-1.2-1.5-1.31.4-1.2-1.5-1.5
Patch foraging total patch changes 6 sec0.60.91.40.9-1.20.8-1.0-0.9-0.90.7-0.7-1.1-1.1
Patch foraging time to switch 0 sec0.81.32.5-0.50.8-0.40.91.31.6-1.41.51.21.2
Patch foraging water rate 0 sec0.40.61.30.2-0.40.1-0.6-0.9-1.11.0-1.1-0.8-0.8
Patch foraging water rate 12 sec0.50.81.50.5-0.40.4-0.8-0.9-1.21.1-1.2-0.9-0.9
Patch foraging water rate 18 sec0.00.00.1-0.10.2-0.10.0-0.0-0.40.1-0.20.10.1
Patch foraging water rate 24 sec0.20.30.8-0.60.8-0.90.60.6-0.0-0.30.20.40.4
Patch foraging water rate 6 sec0.60.82.4-0.1-0.1-0.1-0.5-0.7-1.51.1-1.4-0.9-0.9
Seeking ratio, delayed vs. immediate footshock0.10.10.40.00.2-0.20.20.10.6-0.30.60.50.5
Distance traveled before self-admin0.50.61.1-0.50.7-0.20.81.10.7-0.90.70.80.8
Distance traveled after self-admin0.91.01.5-0.50.9-0.40.91.11.1-1.21.21.21.2
Extensor digitorum longus weight7.830.836.0-5.75.7-6.05.55.25.5-5.45.65.45.4
Bone: elastic displacement0.60.72.21.5-1.01.0-1.1-0.7-0.30.6-0.4-0.6-0.6
Bone: elastic work0.20.31.11.1-0.60.7-0.8-0.40.00.4-0.1-0.3-0.3
Bone: endosteal estimation0.40.93.0-1.71.4-1.51.00.70.2-0.60.30.40.4
Bone: endosteal perimeter0.61.23.0-1.71.6-1.61.21.10.4-0.90.50.70.7
Epididymis fat weight1.73.94.72.2-1.82.1-2.1-1.7-2.11.8-2.0-1.9-1.9
Delta time in closed arm before/after self-admin0.10.10.2-0.30.0-0.50.1-0.20.10.1-0.0-0.3-0.3
Delta time in open arm before/after self-admin2.62.54.52.0-1.62.1-1.6-1.2-1.51.3-1.5-1.4-1.4
Diff in mean of infusions in LGA sessions0.10.20.2-0.40.4-0.30.40.40.5-0.40.30.40.4
Delay discount exponential model param1.51.62.31.0-1.41.1-1.2-1.5-1.31.4-1.1-1.2-1.2
Extinction: sum of active levers before priming0.90.92.8-1.41.1-1.70.80.20.4-0.50.70.80.8
Active lever presses in extinction session 60.30.21.0-0.50.7-1.00.40.50.2-0.40.30.10.1
Bone: final force0.71.12.4-1.51.4-1.31.21.10.6-0.90.70.70.7
Bone: final moment0.91.53.3-1.81.6-1.61.41.20.7-1.00.90.90.9
Food consumed during 24 hour testing period0.30.40.70.2-0.40.6-0.5-0.8-0.80.8-0.8-0.6-0.6
Glucose0.00.10.20.2-0.10.4-0.10.00.3-0.10.30.20.2
Heart weight0.00.00.10.2-0.10.3-0.10.4-0.0-0.1-0.1-0.2-0.2
Delay discount hyperbolic model param2.12.23.01.2-1.61.3-1.5-1.7-1.51.6-1.4-1.4-1.4
Intermittent access intake day 1-15 change0.20.20.6-0.20.6-0.40.50.80.3-0.50.20.40.4
Intermittent access intake escalation0.20.20.5-0.30.6-0.60.50.70.2-0.40.10.40.4
Intermittent access intake escalation 20.10.10.4-0.30.5-0.40.40.6-0.1-0.4-0.00.00.0
Intermitt. access day 1 inactive lever presses1.31.42.3-1.10.8-0.21.00.71.5-1.11.51.41.4
Intermitt. access day 15 inactive lever presses0.20.20.80.5-0.20.9-0.30.1-0.30.1-0.4-0.4-0.4
Intermitt. access escalation Index3.22.84.2-1.71.4-1.11.81.32.0-1.61.91.81.8
Intermittent access day 1 total infusions0.10.10.20.20.10.30.10.50.2-0.30.10.30.3
Intermittent access day 15 total infusions0.20.21.10.10.50.10.51.00.3-0.60.20.50.5
Intermittent access terminal intake (last 3 days)1.31.43.0-0.61.2-0.51.31.71.1-1.41.01.31.3
Intermittent access total infusions1.01.12.9-0.61.1-0.51.11.70.8-1.30.81.11.1
Intermittent access day 1 locomotion0.00.00.00.2-0.10.2-0.10.1-0.0-0.0-0.00.20.2
Intermittent access day 15 total locomotion0.10.10.4-0.20.5-0.20.40.60.1-0.40.20.30.3
Intermittent access total locomotion0.60.71.5-0.50.8-0.50.81.20.7-1.00.70.80.8
Intermittent access standard deviation0.50.51.10.8-0.41.0-0.50.0-1.00.5-1.0-0.8-0.8
Left kidney weight0.10.20.5-0.70.5-0.40.50.40.4-0.30.40.10.1
Right kidney weight0.61.72.8-1.71.3-1.31.41.21.5-1.21.41.01.0
Cocaine induced anxiety3.23.74.5-1.81.9-1.52.02.12.0-2.01.91.91.9
Post-drug Anxiety5.05.66.3-2.52.4-2.42.52.22.3-2.22.22.42.4
Baseline Anxiety0.60.60.90.5-0.60.3-0.7-0.9-1.00.9-0.9-0.8-0.8
Tail length0.30.81.11.0-1.00.8-0.9-1.1-0.80.9-0.8-0.9-0.9
Length with tail0.00.00.10.4-0.20.3-0.20.1-0.1-0.1-0.0-0.1-0.1
Length without tail0.40.82.0-0.60.9-0.50.91.40.7-1.20.90.90.9
Times rat made contact with spout0.20.30.50.1-0.30.0-0.4-0.6-0.60.7-0.7-0.6-0.6
Lifetime Intake0.60.71.4-0.40.8-0.40.81.20.7-1.00.70.90.9
Liver weight, left0.40.61.1-0.91.0-1.00.81.00.4-0.90.60.50.5
Liver weight, right0.00.00.2-0.40.3-0.10.2-0.0-0.20.2-0.2-0.1-0.1
Locomotor activity0.00.00.2-0.10.0-0.10.2-0.10.4-0.20.40.20.2
Locomotor testing distance0.10.10.30.4-0.50.3-0.2-0.50.20.30.2-0.1-0.1
Locomotor testing rearing0.00.00.10.2-0.1-0.1-0.1-0.3-0.00.2-0.2-0.1-0.1
Locomotion in novel chamber3.13.95.4-1.91.9-2.12.01.62.3-1.82.11.91.9
Locomotion in novel chamber post-restriction1.61.93.2-1.51.2-1.41.41.01.8-1.21.71.31.3
Fecal boli incidents, locomotor time 13.43.74.32.1-1.82.0-1.9-1.6-2.01.8-2.1-1.9-1.9
Change in fecal boli incidents, locomotor task0.80.81.1-1.10.8-1.00.90.61.0-0.80.80.90.9
Time >=10cm from walls, locomotor time 10.60.60.80.8-0.70.8-0.7-0.9-0.90.9-0.9-0.6-0.6
Bouts of movement, locomotor time 10.70.71.41.0-0.91.2-0.8-0.7-0.70.8-0.8-0.7-0.7
Total resting periods, locomotor time 11.71.92.41.5-1.51.5-1.4-1.4-1.21.4-1.2-1.2-1.2
Rest time, locomotor task time 10.20.20.30.5-0.50.5-0.4-0.5-0.30.4-0.3-0.3-0.3
Distance moved, locomotor task time 10.60.61.4-0.70.7-1.20.70.61.0-0.70.80.70.7
Vertical activity count, locomotor time 12.42.53.4-1.41.5-1.21.61.81.8-1.71.61.51.5
Time >=10cm from walls, locomotor time 20.00.00.10.2-0.00.10.1-0.20.00.10.00.30.3
Bouts of movement, locomotor time 21.92.02.3-1.51.4-1.41.51.31.3-1.31.41.51.5
Total resting periods, locomotor time 22.02.12.4-1.51.4-1.41.51.41.4-1.41.41.51.5
Rest time, locomotor task time 20.60.60.80.8-0.90.9-0.7-0.7-0.90.7-0.8-0.8-0.8
Distance moved, locomotor task time 20.10.10.3-0.10.1-0.40.10.00.5-0.20.40.40.4
Vertical activity count, locomotor time 21.21.31.8-0.81.1-1.11.11.31.3-1.21.21.11.1
Light reinforcement 11.93.54.21.6-1.91.8-1.8-2.0-2.01.9-1.8-1.9-1.9
Light reinforcement 20.81.12.31.3-1.21.5-1.0-0.9-1.01.0-0.9-0.7-0.7
Bone: marrow area0.51.03.1-1.81.4-1.51.00.70.2-0.60.30.40.4
Bone: maximum diameter0.20.40.9-0.90.9-0.70.60.50.3-0.50.40.50.5
Bone: maximum force1.11.93.5-1.91.8-1.51.51.40.8-1.21.01.11.1
Bone: maximum moment1.32.24.3-2.11.9-1.81.61.40.9-1.31.11.21.2
Mean time between licks in bursts0.20.20.50.6-0.70.5-0.5-0.60.00.3-0.0-0.4-0.4
Mean num. licks in bursts0.10.20.4-0.20.50.10.40.60.1-0.40.20.60.6
Cd content in liver0.30.30.6-0.10.3-0.30.30.70.7-0.70.80.50.5
Co content in liver0.50.61.3-1.00.8-1.10.70.50.6-0.60.60.70.7
Cu content in liver5.76.99.6-3.02.9-3.12.72.52.3-2.42.42.42.4
Fe content in liver0.00.00.10.3-0.20.1-0.2-0.20.10.2-0.00.00.0
K content in liver0.30.30.50.0-0.4-0.1-0.4-0.6-0.60.6-0.5-0.7-0.7
Mg content in liver0.30.30.50.1-0.4-0.0-0.4-0.7-0.60.7-0.6-0.6-0.6
Mn content in liver0.00.00.0-0.1-0.10.10.1-0.10.20.1-0.00.00.0
Na content in liver0.10.20.3-0.60.4-0.20.60.40.3-0.30.30.40.4
Rb content in liver0.50.61.8-0.90.9-1.40.70.60.4-0.60.50.50.5
Se content in liver0.10.10.70.7-0.40.8-0.3-0.1-0.30.00.00.00.0
Sr content in liver1.91.72.30.9-1.11.1-1.1-1.5-1.31.5-1.4-1.4-1.4
Zn content in liver3.64.04.71.8-1.91.6-2.0-2.2-1.92.2-2.1-2.1-2.1
Bone: minimum diameter0.81.53.0-1.71.6-1.41.21.00.9-1.11.00.90.9
Time in familiar zone, hab. session 10.10.10.40.6-0.40.5-0.4-0.2-0.20.3-0.4-0.2-0.2
Time in novel zone, hab. session 10.80.71.1-1.00.9-1.00.90.70.8-0.90.90.80.8
Total zone transitions, hab. session 10.50.71.20.8-1.01.1-0.7-0.8-0.90.8-0.8-0.9-0.9
Total locomotion distance, hab. session 13.55.05.82.1-2.22.2-2.1-2.1-2.32.2-2.4-2.2-2.2
Locomotion velocity, hab. session 13.04.25.02.0-2.01.9-1.9-1.9-2.22.1-2.2-2.1-2.1
Time in familiar zone, hab. session 20.80.81.1-1.10.9-1.00.90.81.0-0.91.00.80.8
Time in novel zone, hab. session 20.10.10.20.3-0.30.1-0.4-0.4-0.30.3-0.4-0.4-0.4
Total zone transitions, hab. session 21.92.52.81.5-1.61.7-1.5-1.4-1.51.5-1.6-1.7-1.7
Total locomotion distance, hab. session 26.18.19.72.6-2.72.3-2.7-2.8-3.02.9-3.1-3.1-3.1
Locomotion velocity, hab. session 26.38.410.12.6-2.72.5-2.8-2.8-3.13.0-3.2-3.1-3.1
Novel to familiar place preference ratio0.00.00.1-0.20.1-0.20.1-0.2-0.10.1-0.2-0.1-0.1
Novelty place preference0.00.00.2-0.1-0.0-0.20.0-0.4-0.20.2-0.2-0.2-0.2
Time in novel zone, NPP test0.00.00.2-0.30.1-0.40.1-0.2-0.00.1-0.1-0.0-0.0
Total zone transitions, NPP test4.56.47.52.6-2.72.7-2.5-2.3-2.42.4-2.4-2.6-2.6
Total locomotion distance, NPP test10.013.714.33.6-3.83.5-3.6-3.6-3.73.8-3.8-3.8-3.8
Locomotion velocity, NPP test11.215.916.93.8-4.03.7-3.9-4.0-4.14.1-4.1-4.1-4.1
Intraocular pressure0.81.11.9-0.60.7-0.50.91.21.4-1.31.31.11.1
Delta distance traveled before/after self-admin1.11.21.71.0-1.00.8-1.2-1.3-0.91.1-1.0-1.2-1.2
Delta ambulatory time before/after self-admin0.80.91.10.8-0.80.8-1.0-1.0-0.80.9-0.9-1.1-1.1
Parametrial fat weight4.38.49.52.9-2.92.6-3.0-2.7-3.02.7-3.0-3.1-3.1
Pavlov. Cond. lever latency0.20.30.90.60.20.50.10.90.3-0.60.20.70.7
Pavlov. Cond. magazine entry latency2.73.54.6-2.11.7-1.81.91.52.2-1.72.11.81.8
Pavlov. Cond. change in total contacts1.41.52.8-1.71.2-1.61.30.91.1-0.91.11.01.0
Pavlov. Cond. index score1.62.14.2-2.01.4-2.01.50.81.5-1.11.51.11.1
Pavlov. Cond. latency score1.11.53.5-1.91.2-1.81.20.51.2-0.81.10.80.8
Pavlov. Cond. lever contacts0.20.20.9-1.00.2-0.90.3-0.40.20.10.2-0.2-0.2
Pavlov. Cond. magazine entry number1.31.62.21.5-1.11.3-1.3-0.9-1.51.1-1.4-1.2-1.2
Pavlov. Cond. intertrial magazine entries1.31.63.01.7-1.51.6-1.3-1.0-1.11.0-1.0-1.0-1.0
Pavlov. Cond. lever-magazine prob. diff.1.72.24.2-2.01.4-1.91.50.81.6-1.11.51.21.2
Pavlov. Cond. response bias1.31.62.5-1.61.1-1.41.20.81.5-1.11.51.11.1
Pavlov. Cond. lever latency0.50.71.4-1.20.9-1.11.00.60.7-0.60.80.70.7
Pavlov. Cond. magazine entry latency1.31.52.91.7-1.31.6-1.3-0.9-1.11.1-1.1-0.9-0.9
Pavlov. Cond. change in total contacts0.60.81.1-0.70.8-0.70.91.11.0-1.11.01.01.0
Pavlov. Cond. index score0.91.12.51.6-1.11.5-1.2-0.7-0.90.8-1.0-0.8-0.8
Pavlov. Cond. latency score0.91.12.31.5-1.11.4-1.2-0.7-0.90.9-1.0-0.8-0.8
Pavlov. Cond. lever contacts1.31.82.81.7-1.41.5-1.5-1.1-1.31.2-1.3-1.2-1.2
Pavlov. Cond. magazine entry number0.20.30.8-0.90.6-0.90.50.10.5-0.30.50.30.3
Pavlov. Cond. intertrial magazine entries0.50.71.00.6-0.60.6-0.7-0.8-1.00.9-0.9-0.9-0.9
Pavlov. Cond. lever-magazine prob. diff.0.40.51.41.2-0.81.1-0.8-0.3-0.50.5-0.6-0.4-0.4
Pavlov. Cond. response bias0.60.81.61.3-0.91.2-1.0-0.6-0.70.6-0.8-0.7-0.7
Time in closed arm before self-admin0.10.10.2-0.1-0.30.4-0.1-0.50.10.3-0.2-0.2-0.2
Time in closed arm after self-admin0.70.71.1-1.10.7-1.00.90.61.0-0.70.90.70.7
Time in open arm before self-admin3.94.25.0-1.82.1-1.92.12.01.8-2.12.22.22.2
Time in open arm after self-admin0.40.41.10.9-0.61.1-0.6-0.5-0.70.4-0.5-0.4-0.4
Bone: periosteal estimation0.61.23.6-1.91.6-1.51.20.90.4-0.80.60.60.6
Bone: periosteal perimeter1.32.13.5-1.81.9-1.71.51.51.0-1.31.11.31.3
Bone: post-yield work0.50.71.8-1.31.2-1.00.90.80.2-0.60.40.50.5
Progressive ratio test 1 active lever presses0.30.30.90.9-0.60.8-0.5-0.2-0.50.3-0.5-0.2-0.2
Progressive ratio test 1 breakpoint0.20.20.70.8-0.60.8-0.4-0.2-0.40.3-0.4-0.1-0.1
Progressive ratio test 1 inactive lever presses0.20.20.40.30.00.70.10.50.3-0.50.20.50.5
Progressive ratio test 2 active lever presses0.91.01.8-0.71.1-0.41.11.40.9-1.10.91.11.1
Progressive ratio test 2 breakpoint1.11.22.2-0.81.2-0.41.21.51.0-1.20.91.21.2
Progressive ratio test 2 inactive lever presses0.60.72.0-0.30.9-0.00.81.40.5-1.10.50.90.9
Incentive Sensitization - Responses1.01.12.1-1.11.4-0.81.31.50.8-1.10.60.70.7
Incentive Sensitization - Breakpoint1.51.52.8-1.31.6-1.01.51.71.0-1.30.80.90.9
Sum of active levers in priming session hrs 5-61.31.22.1-0.81.0-0.81.01.11.1-1.31.41.21.2
Progressive ratio0.20.20.5-0.30.5-0.70.30.70.5-0.60.50.30.3
Food seeking constrained by brief footshock0.10.10.30.2-0.40.1-0.4-0.5-0.10.3-0.2-0.5-0.5
Seeking ratio, punishment vs. effort0.10.10.30.2-0.40.5-0.2-0.5-0.10.4-0.2-0.1-0.1
Retroperitoneal fat weight0.72.44.32.0-1.62.1-1.6-1.2-1.51.4-1.5-1.3-1.3
Reaction time number correct0.10.20.5-0.50.5-0.70.40.60.2-0.40.40.40.4
Reaction time mean minus median0.20.20.40.10.10.20.30.60.6-0.70.50.60.6
Reaction time mean minus median AUC0.91.21.9-0.40.7-0.40.81.31.4-1.31.31.41.4
Reaction time num false alarms3.24.44.92.0-2.12.2-2.1-2.2-2.22.1-2.1-2.1-2.1
Reaction time num false alarms AUC2.02.84.41.8-1.82.1-1.6-1.6-1.61.5-1.5-1.6-1.6
Reaction time trials correct on left0.10.20.5-0.50.5-0.70.40.60.2-0.40.40.40.4
Reaction time trials on left0.10.10.3-0.30.4-0.60.30.50.1-0.30.30.30.3
Reaction time mean0.00.00.3-0.00.20.10.10.50.0-0.3-0.10.20.2
Reaction time mean AUC0.20.20.7-0.30.5-0.20.40.80.3-0.60.30.40.4
Median of all reaction times0.00.00.1-0.00.2-0.0-0.00.3-0.2-0.1-0.3-0.1-0.1
Reaction time omissions1.52.13.31.8-1.61.8-1.5-1.1-1.31.3-1.4-1.3-1.3
Reaction time false alarm rate1.62.23.51.5-1.61.9-1.4-1.5-1.31.4-1.4-1.4-1.4
Reaction time premature initiation rate0.30.51.40.7-0.71.2-0.6-0.7-0.50.7-0.6-0.4-0.4
Reaction time premature initiations0.10.10.50.3-0.30.7-0.3-0.3-0.30.3-0.3-0.1-0.1
Std. dev. reaction times0.20.30.50.00.20.10.30.70.6-0.70.50.60.6
Reaction time trials completed0.10.10.3-0.30.4-0.60.30.50.1-0.30.30.30.3
Reaction time trials AUC0.10.20.5-0.50.5-0.70.40.50.2-0.40.40.30.3
Run reversals in cocaine runway, females0.30.30.5-0.50.5-0.30.40.30.7-0.50.70.60.6
Run reversals in cocaine runway, males0.20.20.4-0.10.2-0.40.20.40.5-0.50.70.50.5
Latency to leave start box in cocaine runway0.10.10.5-0.30.1-0.20.30.00.7-0.10.30.20.2
Latency to leave start box in cocaine runway, F0.10.10.30.5-0.50.4-0.4-0.5-0.10.3-0.2-0.2-0.2
Latency to leave start box in cocaine runway, M1.21.22.4-1.31.1-1.01.31.01.6-0.80.90.80.8
Std. dev. time between licks in bursts1.62.02.71.2-1.40.9-1.5-1.6-1.11.4-1.2-1.6-1.6
Total sessions with >9 infusions1.61.82.1-1.21.3-1.51.31.41.4-1.31.31.31.3
Short access day 1 total inactive lever presses2.12.34.1-0.91.3-0.61.31.62.0-1.71.81.81.8
Short access day 10 total inactive lever presses0.91.01.4-1.11.0-0.50.90.81.1-1.01.11.21.2
Short access day 1 total infusions0.20.20.5-0.10.3-0.20.40.20.7-0.40.60.70.7
Short access day 10 total infusions0.10.10.20.5-0.20.4-0.20.2-0.1-0.1-0.1-0.1-0.1
Short access total infusions0.00.00.10.00.1-0.20.10.30.2-0.20.10.20.2
Short access day 1 locomotion0.10.10.30.4-0.20.5-0.20.1-0.20.1-0.2-0.1-0.1
Short access day 10 total locomotion0.30.30.50.7-0.60.7-0.6-0.5-0.50.5-0.5-0.5-0.5
Short access total locomotion0.20.20.50.7-0.50.4-0.6-0.2-0.50.4-0.5-0.4-0.4
One hour access (0.3 mA shock)4.04.76.2-2.22.4-2.32.32.51.7-2.31.91.91.9
Compulsive drug intake0.70.72.3-1.51.0-0.81.10.50.6-0.60.60.40.4
One hour access (shock baseline)4.45.16.8-1.72.3-2.22.22.62.2-2.52.22.32.3
Social response proportion0.20.20.90.8-0.61.0-0.4-0.1-0.0-0.0-0.0-0.2-0.2
Social responses1.41.82.51.5-1.61.5-1.3-1.3-1.21.2-1.1-1.3-1.3
Social time1.01.32.21.3-1.41.2-1.2-1.5-0.81.1-0.8-0.9-0.9
Soleus weight1.02.93.6-1.51.7-1.31.71.71.8-1.71.81.91.9
Bone: stiffness1.52.35.4-2.31.9-1.81.81.50.7-1.31.01.11.1
Tibialis anterior weight5.819.925.7-4.84.5-5.14.54.24.4-4.44.44.14.1
Time to tail flick, vehicle, before self-admin0.10.10.2-0.10.20.00.30.40.5-0.40.30.30.3
Time to tail flick, vehicle, after self-admin0.10.10.2-0.30.1-0.3-0.10.0-0.30.1-0.3-0.4-0.4
Time to tail flick, test, before self-admin0.30.31.70.7-0.61.3-0.4-0.3-0.30.2-0.3-0.1-0.1
Time to tail flick, test, after self-admin1.01.01.6-1.21.0-0.81.10.71.3-0.81.01.01.0
Delta time to tail flick, vehicle, before/after SA0.20.20.6-0.20.0-0.4-0.2-0.1-0.80.3-0.5-0.7-0.7
Delta time to tail flick, test, before/after SA0.80.71.7-1.30.9-1.30.80.41.0-0.40.70.60.6
Tibia length0.10.30.7-0.80.8-0.80.50.50.3-0.50.40.40.4
Ambulatory time before self-admin0.70.71.0-0.70.7-0.40.90.90.8-1.00.91.01.0
Ambulatory time after self-admin0.91.01.5-0.71.0-0.51.01.11.1-1.21.21.11.1
Bone: tissue strength2.32.22.8-1.61.5-1.71.41.41.4-1.51.51.41.4
Total heroin consumption0.60.71.8-1.11.2-1.30.91.00.4-0.70.40.40.4
Bone: trabecular number0.10.10.2-0.1-0.10.4-0.1-0.2-0.50.3-0.4-0.5-0.5
Bone: trabecular spacing0.40.60.8-0.60.7-0.70.80.80.7-0.70.70.90.9
Bone: trabecular thickness0.30.40.60.4-0.50.7-0.5-0.5-0.80.5-0.7-0.7-0.7
Bone: trabecular tissue density0.00.00.0-0.00.10.00.1-0.1-0.20.1-0.10.00.0
Water consumed over 24 hours0.10.10.30.1-0.2-0.0-0.3-0.4-0.50.5-0.5-0.5-0.5
Number of responses in last shaping day0.70.72.31.5-0.81.5-0.9-0.2-0.70.5-0.6-0.2-0.2