Hub : Genes

Prph

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Prph	0.08	0.07	2.2e-05	0.05	0.05	0.05	0.05	1.2e-04	7.2e-05	7.2e-05	1.3e-04
2	LHb	gene expression	Prph	0.37	0.19	2.9e-08	0.22	0.26	0.24	0.26	6.0e-06	5.2e-07	1.6e-06	8.5e-07
3	Adipose	gene expression	Prph	0.09	0.08	5.6e-08	0.06	0.06	0.06	0.06	4.3e-07	4.9e-07	2.3e-07	8.5e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	8.7	15.1	17.3	-3.4	4.2	-4.0
Area under the delay curve	1.0	1.2	1.6	-1.3	0.9	-1.1
BMI with tail	7.5	25.8	27.2	-5.1	4.9	-5.2
BMI without tail	2.1	6.5	7.8	-2.5	2.3	-2.8
Body weight	7.3	32.1	34.6	-5.6	5.5	-5.9
Weight adjusted by age	2.2	3.3	4.7	-1.3	1.9	-2.2
Bone surface	10.9	19.9	21.9	-4.2	4.7	-4.5
Bone volume	8.3	14.8	16.4	-3.7	4.1	-3.8
Breakpoint value in progressive ratio session	1.3	1.6	1.8	-1.3	1.4	-1.2
Number of licking bursts	0.7	1.1	2.7	1.6	-0.7	0.1
Context. condit. distance diff. score	0.3	0.4	0.8	-0.2	0.5	-0.9
Locomotion velocity, session 1	1.7	1.9	3.0	1.7	-1.0	1.3
Locomotion distance, session 1	3.3	4.2	5.5	1.9	-1.8	2.3
Locomotion velocity, session 2	0.4	0.4	0.8	0.4	-0.5	0.9
Locomotion distance, session 2	2.6	3.7	5.1	1.7	-1.8	2.3
Locomotion velocity, session 3	5.0	5.7	6.6	2.6	-2.2	2.4
Locomotion distance, session 3	5.0	5.4	6.5	2.0	-2.4	2.5
Stereotopy head waving bouts, day 3	0.7	0.8	1.4	-0.5	1.2	-0.9
Stereotopy head waving duration, day 3	0.3	0.4	0.8	-0.3	0.9	-0.4
Locomotion velocity, session 7	0.7	0.8	2.1	1.4	-0.6	0.2
Locomotion distance, session 7	2.0	2.5	4.3	2.1	-1.5	0.9
Stereotopy head waving bouts, day 7	1.1	1.3	1.6	-0.9	1.2	-1.3
Stereotopy head waving duration, day 7	1.1	1.3	1.4	-1.1	1.2	-1.1
Locomotion velocity, session 8	0.2	0.2	0.6	0.8	0.0	-0.0
Locomotion distance, session 8	1.2	1.7	2.1	1.4	-1.3	1.2
Degree of sensitization distance	0.6	0.6	1.4	-0.3	0.7	-1.2
Degree of sensitization stereotypy	0.2	0.3	0.3	-0.6	0.3	-0.6
Conditioned locomotion	0.0	0.1	0.1	0.4	0.1	0.1
Cocaine response after cond. corrected	0.0	0.0	0.0	-0.0	-0.1	0.2
Cocaine response after cond. not corrected	0.6	0.7	0.9	0.7	-0.8	0.9
Cocaine response before conditioning	3.4	4.1	4.4	2.0	-2.1	2.0
Saline control response	0.0	0.1	0.1	0.3	0.2	-0.1
Bone: connectivity density	5.7	8.9	10.9	-2.5	3.3	-3.1
Bone: cortical apparent density	0.2	0.2	0.3	0.4	-0.5	0.5
Bone: cortical area	10.2	15.6	17.7	-3.5	4.2	-4.2
Bone: cortical porosity	0.8	0.9	1.9	0.3	-0.8	1.4
Bone: cortical porosity	1.0	1.0	2.1	0.4	-1.0	1.4
Bone: cortical thickness	3.5	5.7	7.1	-1.8	2.6	-2.7
Bone: cortical thickness	0.2	0.2	0.5	-0.1	0.3	-0.7
Bone: cortical tissue density	0.2	0.3	0.4	0.5	-0.6	0.6
Condit. Reinf. active minus inactive responses	0.2	0.3	0.6	0.4	-0.2	0.8
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.3	0.6	0.1
Condit. Reinf. active responses	0.9	1.1	1.7	1.0	-0.8	1.3
Condit. Reinf. inactive responses	2.7	3.3	3.7	1.8	-1.9	1.8
Incentive salience index mean	0.0	0.0	0.0	0.2	0.1	0.2
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.5	0.3	-0.2
Condit. Reinf. active minus inactive responses	0.0	0.1	0.2	-0.4	-0.1	0.0
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	-0.2	-0.6	0.5
Condit. Reinf. active responses	0.1	0.1	0.3	0.0	-0.5	0.3
Condit. Reinf. inactive responses	0.4	0.6	0.7	0.8	-0.8	0.6
Condit. Reinf. lever presses	0.0	0.0	0.1	0.1	0.1	-0.3
Condit. Reinf. lever reinforcers received	0.3	0.4	0.7	0.5	-0.8	0.6
Conditioned reinforcement - actives	0.6	1.1	1.9	0.6	-1.4	1.0
Conditioned reinforcement - inactives	3.8	5.6	6.3	2.3	-2.5	2.3
Conditioned locomotion	0.2	0.2	0.3	0.5	-0.5	0.4
Patch foraging indifference point 0 sec	3.4	6.3	11.1	3.3	-2.0	1.9
Patch foraging indifference point AUC	0.7	0.9	1.2	1.0	-1.1	0.7
Delay disc. indifference point, 0s delay	1.4	1.5	2.1	-1.5	1.2	-1.1
Delay disc. indifference point, 16s delay	1.1	1.2	1.6	-1.3	0.9	-1.1
Delay disc. indifference point, 2s delay	1.4	1.6	1.9	-1.4	1.2	-1.1
Delay disc. indifference point, 24s delay	1.0	1.1	1.5	-0.8	1.0	-1.2
Delay disc. indifference point, 4s delay	0.8	0.8	1.7	-1.3	0.6	-0.6
Delay disc. indifference point, 8s delay	2.1	2.5	3.0	-1.5	1.5	-1.7
Indifference point function ln k	3.1	5.4	6.4	-2.5	2.3	-2.1
Indifference point function log k	3.1	5.4	6.4	-2.5	2.3	-2.1
Patch foraging total patch changes 0 sec	3.2	6.1	10.7	3.3	-2.0	1.9
Patch foraging total patch changes 12 sec	3.5	4.6	7.6	2.8	-1.9	1.6
Patch foraging total patch changes 18 sec	4.6	7.0	10.5	3.2	-2.4	2.2
Patch foraging total patch changes 24 sec	2.4	4.1	6.9	2.6	-1.8	1.5
Patch foraging total patch changes 6 sec	4.2	6.4	11.2	3.3	-2.1	1.9
Patch foraging time to switch 0 sec	1.7	3.6	3.7	1.9	-1.9	1.9
Patch foraging water rate 0 sec	2.6	5.4	5.7	-2.4	2.3	-2.3
Patch foraging water rate 12 sec	2.5	5.3	5.7	-2.4	2.3	-2.2
Patch foraging water rate 18 sec	0.4	0.6	0.8	-0.9	0.6	-0.8
Patch foraging water rate 24 sec	3.7	5.2	6.9	-2.6	2.2	-2.0
Patch foraging water rate 6 sec	4.6	6.7	8.6	-2.9	2.5	-2.3
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	-0.4	0.3	-0.3
Distance traveled before self-admin	1.2	1.6	2.5	1.6	-1.0	1.1
Distance traveled after self-admin	0.7	0.9	1.8	1.3	-0.5	0.8
Extensor digitorum longus weight	4.8	18.9	20.8	-4.6	3.9	-4.5
Bone: elastic displacement	5.2	6.0	6.9	2.6	-2.1	2.6
Bone: elastic work	0.1	0.1	0.2	-0.0	0.2	0.4
Bone: endosteal estimation	8.4	18.5	19.1	-4.4	4.3	-4.2
Bone: endosteal perimeter	7.8	16.6	17.4	-4.1	3.9	-4.2
Epididymis fat weight	0.7	2.4	3.1	-1.3	1.8	-1.6
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	0.0	-0.1	0.1
Delta time in open arm before/after self-admin	1.3	1.3	1.6	1.3	-1.1	1.1
Diff in mean of infusions in LGA sessions	1.0	1.3	1.6	-1.2	1.2	-0.9
Delay discount exponential model param	1.0	1.2	1.6	1.3	-0.8	1.1
Extinction: sum of active levers before priming	1.8	1.9	2.6	-1.6	1.4	-1.1
Active lever presses in extinction session 6	0.7	0.7	1.2	-0.5	1.1	-0.8
Bone: final force	11.3	18.0	19.9	-4.5	4.3	-3.9
Bone: final moment	12.2	19.7	22.1	-4.7	4.5	-4.0
Food consumed during 24 hour testing period	1.2	1.7	2.2	-1.0	1.5	-1.4
Glucose	0.2	0.4	0.8	0.4	0.4	-0.9
Heart weight	0.2	0.3	0.5	-0.6	0.3	-0.7
Delay discount hyperbolic model param	1.0	1.1	1.6	1.3	-0.8	1.0
Intermittent access intake day 1-15 change	0.1	0.1	0.2	-0.5	-0.4	-0.2
Intermittent access intake escalation	0.1	0.3	0.7	-0.8	-0.1	-0.4
Intermittent access intake escalation 2	0.1	0.1	0.3	-0.2	-0.5	0.1
Intermitt. access day 1 inactive lever presses	0.2	0.9	1.4	0.5	-0.9	1.2
Intermitt. access day 15 inactive lever presses	0.4	0.8	1.5	0.2	-1.2	0.9
Intermitt. access escalation Index	0.4	0.5	1.0	-0.1	0.8	-1.0
Intermittent access day 1 total infusions	1.1	1.7	2.2	1.5	-1.2	1.2
Intermittent access day 15 total infusions	0.6	0.9	1.5	0.7	-1.2	0.7
Intermittent access terminal intake (last 3 days)	1.0	1.4	2.0	0.9	-1.4	1.1
Intermittent access total infusions	1.7	2.0	2.7	1.3	-1.6	1.3
Intermittent access day 1 locomotion	0.3	0.3	0.8	0.9	-0.3	0.3
Intermittent access day 15 total locomotion	0.2	0.3	0.6	0.8	-0.6	0.1
Intermittent access total locomotion	1.5	1.8	2.5	1.6	-1.3	1.0
Intermittent access standard deviation	0.1	0.3	0.6	-0.0	-0.8	0.4
Left kidney weight	1.0	4.7	7.3	-2.7	1.9	-1.7
Right kidney weight	4.5	20.6	23.9	-4.9	4.4	-4.3
Cocaine induced anxiety	2.9	4.2	5.4	-1.8	2.0	-2.3
Post-drug Anxiety	4.0	4.3	4.8	-2.1	1.9	-2.2
Baseline Anxiety	0.1	0.1	0.2	-0.5	0.1	0.0
Tail length	0.0	0.1	0.2	0.2	0.0	-0.4
Length with tail	1.6	6.8	7.7	-2.4	2.6	-2.8
Length without tail	5.4	17.5	18.4	-4.1	4.3	-4.1
Times rat made contact with spout	0.2	0.2	0.4	0.6	-0.3	0.3
Lifetime Intake	2.3	2.8	3.5	1.6	-1.9	1.5
Liver weight, left	10.3	17.1	18.3	-4.1	4.1	-4.3
Liver weight, right	2.9	5.0	5.9	-2.4	2.2	-2.1
Locomotor activity	1.4	2.1	2.4	1.6	-1.5	1.3
Locomotor testing distance	3.0	5.5	6.2	2.5	-2.4	2.1
Locomotor testing rearing	1.9	3.8	4.4	2.1	-2.1	1.7
Locomotion in novel chamber	2.0	2.6	4.3	-2.1	1.3	-1.3
Locomotion in novel chamber post-restriction	0.0	0.1	0.1	-0.3	-0.2	0.2
Fecal boli incidents, locomotor time 1	1.6	2.3	3.5	1.0	-1.6	1.9
Change in fecal boli incidents, locomotor task	0.5	0.5	0.9	-0.2	1.0	-0.7
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.2	0.2	-0.3
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.0	0.0	0.4
Total resting periods, locomotor time 1	0.5	0.5	1.0	0.6	-0.5	1.0
Rest time, locomotor task time 1	0.6	0.8	1.1	1.0	-0.6	1.0
Distance moved, locomotor task time 1	0.1	0.2	0.4	0.2	0.2	-0.6
Vertical activity count, locomotor time 1	0.8	1.9	2.9	-1.1	1.2	-1.7
Time >=10cm from walls, locomotor time 2	0.5	0.7	1.1	0.4	-0.9	1.0
Bouts of movement, locomotor time 2	2.1	3.3	3.4	-1.7	1.9	-1.9
Total resting periods, locomotor time 2	2.0	3.6	3.9	-1.7	1.9	-2.0
Rest time, locomotor task time 2	0.1	0.1	0.4	0.6	-0.0	0.0
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.1	-0.2	0.2
Vertical activity count, locomotor time 2	0.1	0.2	0.3	-0.4	0.1	-0.6
Light reinforcement 1	1.7	4.1	5.6	1.7	-2.4	1.9
Light reinforcement 2	0.5	0.8	1.3	0.5	-1.1	0.9
Bone: marrow area	8.2	17.8	18.0	-4.2	4.2	-4.2
Bone: maximum diameter	4.0	7.4	9.3	-2.4	2.7	-3.1
Bone: maximum force	16.2	28.7	30.3	-5.5	5.5	-5.1
Bone: maximum moment	17.3	30.4	32.3	-5.7	5.7	-5.2
Mean time between licks in bursts	0.1	0.2	0.3	0.3	-0.4	0.6
Mean num. licks in bursts	0.2	0.4	0.7	-0.8	0.2	0.6
Cd content in liver	0.7	0.8	0.9	0.7	-0.9	0.9
Co content in liver	0.1	0.1	0.3	0.4	-0.6	-0.0
Cu content in liver	0.6	0.8	1.4	-0.4	1.2	-0.9
Fe content in liver	1.6	2.0	2.4	1.4	-1.5	1.3
K content in liver	0.0	0.0	0.1	0.1	0.1	-0.2
Mg content in liver	0.2	0.2	0.2	0.5	-0.3	0.5
Mn content in liver	0.0	0.0	0.1	-0.0	0.1	0.4
Na content in liver	0.0	0.0	0.0	-0.1	-0.2	-0.1
Rb content in liver	0.5	0.6	1.8	1.3	-0.1	-0.2
Se content in liver	2.1	2.5	3.6	1.9	-1.4	1.3
Sr content in liver	1.1	0.9	1.3	-0.5	1.1	-1.1
Zn content in liver	1.0	1.1	1.3	1.1	-1.0	1.0
Bone: minimum diameter	9.6	17.6	18.4	-4.0	4.3	-4.3
Time in familiar zone, hab. session 1	0.2	0.2	0.4	0.3	-0.4	0.6
Time in novel zone, hab. session 1	0.3	0.3	0.5	-0.2	0.5	-0.7
Total zone transitions, hab. session 1	0.2	0.3	0.5	0.3	-0.7	0.6
Total locomotion distance, hab. session 1	0.0	0.1	0.1	0.4	0.1	0.2
Locomotion velocity, hab. session 1	0.0	0.0	0.1	0.3	0.2	0.1
Time in familiar zone, hab. session 2	0.5	0.5	1.1	-1.0	0.7	-0.4
Time in novel zone, hab. session 2	0.5	0.6	1.3	1.1	-0.5	0.3
Total zone transitions, hab. session 2	0.3	0.4	0.6	0.5	-0.6	0.8
Total locomotion distance, hab. session 2	0.2	0.3	0.5	0.6	-0.2	0.7
Locomotion velocity, hab. session 2	0.1	0.2	0.3	0.5	-0.1	0.5
Novel to familiar place preference ratio	1.8	2.0	3.3	-0.8	1.4	-1.8
Novelty place preference	1.3	1.4	2.6	-0.5	1.2	-1.6
Time in novel zone, NPP test	1.1	1.2	2.3	-0.4	1.1	-1.5
Total zone transitions, NPP test	1.9	2.8	3.7	1.9	-1.4	1.7
Total locomotion distance, NPP test	2.6	3.6	4.7	2.2	-1.5	1.9
Locomotion velocity, NPP test	1.6	2.2	3.2	1.8	-1.1	1.5
Intraocular pressure	7.3	10.5	11.0	3.2	-3.2	3.3
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.1	0.0	0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	0.2	-0.2	0.0
Parametrial fat weight	0.7	1.7	2.6	1.0	-1.6	1.2
Pavlov. Cond. lever latency	0.1	0.1	0.3	0.3	0.5	0.0
Pavlov. Cond. magazine entry latency	0.3	0.4	1.3	-1.1	-0.1	0.2
Pavlov. Cond. change in total contacts	0.5	0.6	1.5	-1.2	0.0	-0.4
Pavlov. Cond. index score	0.3	0.4	1.1	-1.0	-0.0	-0.5
Pavlov. Cond. latency score	0.2	0.3	0.8	-0.9	-0.1	-0.4
Pavlov. Cond. lever contacts	0.2	0.3	0.7	-0.2	-0.9	0.3
Pavlov. Cond. magazine entry number	0.2	0.3	0.8	0.9	0.1	0.1
Pavlov. Cond. intertrial magazine entries	1.5	1.8	3.6	1.9	-0.6	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.6	-1.3	0.2	-0.7
Pavlov. Cond. response bias	0.2	0.2	0.3	-0.6	-0.5	0.2
Pavlov. Cond. lever latency	0.3	0.5	1.2	-1.1	0.4	-0.2
Pavlov. Cond. magazine entry latency	0.7	0.9	1.3	-0.1	1.2	-1.1
Pavlov. Cond. change in total contacts	1.2	2.0	3.3	-0.7	1.5	-1.8
Pavlov. Cond. index score	0.5	0.7	1.1	0.3	0.9	-1.0
Pavlov. Cond. latency score	0.4	0.6	0.9	0.4	0.8	-0.9
Pavlov. Cond. lever contacts	0.2	0.3	0.9	0.9	-0.2	0.0
Pavlov. Cond. magazine entry number	1.8	2.2	3.3	0.5	-1.7	1.8
Pavlov. Cond. intertrial magazine entries	5.3	8.0	10.1	2.2	-3.0	3.2
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.5	0.2	1.1	-1.2
Pavlov. Cond. response bias	0.1	0.2	0.3	0.5	0.2	-0.4
Time in closed arm before self-admin	2.5	3.2	4.1	-1.6	1.7	-2.0
Time in closed arm after self-admin	0.3	0.3	0.5	-0.7	0.4	-0.6
Time in open arm before self-admin	0.2	0.2	0.3	0.6	-0.2	0.4
Time in open arm after self-admin	0.2	0.2	0.4	0.6	-0.2	0.5
Bone: periosteal estimation	12.9	27.1	28.6	-5.0	5.3	-5.3
Bone: periosteal perimeter	11.1	19.2	19.7	-4.3	4.4	-4.4
Bone: post-yield work	9.9	14.5	14.9	-3.9	3.8	-3.8
Progressive ratio test 1 active lever presses	6.1	7.6	9.0	3.0	-2.8	2.4
Progressive ratio test 1 breakpoint	5.7	7.0	8.6	2.9	-2.7	2.3
Progressive ratio test 1 inactive lever presses	1.5	2.1	3.2	0.9	-1.8	1.5
Progressive ratio test 2 active lever presses	1.6	1.9	2.8	1.2	-1.7	1.2
Progressive ratio test 2 breakpoint	1.5	1.8	2.6	1.2	-1.6	1.1
Progressive ratio test 2 inactive lever presses	0.9	1.4	2.3	0.8	-1.5	1.1
Incentive Sensitization - Responses	0.3	0.5	0.8	-0.9	0.3	-0.7
Incentive Sensitization - Breakpoint	0.2	0.3	0.6	-0.8	0.2	-0.5
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.2	0.2	0.1
Progressive ratio	0.5	0.7	1.6	1.3	-0.6	0.5
Food seeking constrained by brief footshock	1.2	1.4	2.6	1.6	-1.1	0.8
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	-0.2	-0.1	0.0
Retroperitoneal fat weight	0.4	1.7	2.2	1.3	-1.2	1.5
Reaction time number correct	0.9	1.7	2.3	-1.4	1.5	-0.8
Reaction time mean minus median	4.3	10.6	11.7	3.1	-3.4	3.2
Reaction time mean minus median AUC	2.8	7.1	8.0	2.5	-2.8	2.7
Reaction time num false alarms	1.7	2.4	2.7	1.6	-1.5	1.6
Reaction time num false alarms AUC	2.0	3.2	3.4	1.7	-1.8	1.9
Reaction time trials correct on left	0.9	1.7	2.3	-1.4	1.5	-0.8
Reaction time trials on left	0.7	1.3	1.8	-1.3	1.3	-0.6
Reaction time mean	0.6	1.0	1.3	1.1	-1.1	0.8
Reaction time mean AUC	0.4	0.6	0.8	0.9	-0.8	0.5
Median of all reaction times	0.0	0.0	0.1	0.2	0.0	-0.3
Reaction time omissions	9.6	14.0	15.6	3.4	-3.8	4.0
Reaction time false alarm rate	2.4	3.3	3.7	1.8	-1.9	1.7
Reaction time premature initiation rate	4.2	5.9	8.4	2.0	-2.9	2.2
Reaction time premature initiations	1.5	2.7	3.9	1.1	-2.0	1.7
Std. dev. reaction times	4.7	8.7	9.3	3.0	-3.0	2.9
Reaction time trials completed	0.7	1.3	1.8	-1.3	1.3	-0.6
Reaction time trials AUC	1.1	2.1	2.9	-1.6	1.7	-0.9
Run reversals in cocaine runway, females	0.2	0.2	0.4	-0.6	0.2	-0.3
Run reversals in cocaine runway, males	1.2	1.2	1.4	1.0	-1.1	1.2
Latency to leave start box in cocaine runway	0.0	0.0	0.0	-0.2	-0.2	-0.1
Latency to leave start box in cocaine runway, F	0.8	0.9	1.2	0.7	-1.1	0.9
Latency to leave start box in cocaine runway, M	2.0	1.8	2.0	-1.3	1.3	-1.4
Std. dev. time between licks in bursts	1.0	1.4	2.1	1.5	-1.2	0.7
Total sessions with >9 infusions	2.3	2.8	3.4	1.8	-1.9	1.3
Short access day 1 total inactive lever presses	1.8	2.3	2.8	1.5	-1.7	1.4
Short access day 10 total inactive lever presses	0.1	0.1	0.2	0.3	-0.3	0.5
Short access day 1 total infusions	1.0	1.3	1.9	1.4	-1.1	0.9
Short access day 10 total infusions	1.7	2.2	2.9	1.7	-1.6	1.1
Short access total infusions	2.9	3.6	4.8	2.2	-2.0	1.5
Short access day 1 locomotion	0.3	0.4	0.7	0.8	-0.6	0.2
Short access day 10 total locomotion	0.2	0.3	0.4	0.7	-0.6	0.5
Short access total locomotion	1.0	1.2	1.7	1.3	-1.1	0.7
One hour access (0.3 mA shock)	0.2	0.2	0.3	-0.5	-0.5	-0.1
Compulsive drug intake	0.1	0.1	0.3	-0.5	0.0	0.1
One hour access (shock baseline)	0.1	0.1	0.2	-0.5	-0.2	-0.4
Social response proportion	0.2	0.2	0.4	0.6	-0.5	0.2
Social responses	6.8	8.8	10.3	3.0	-3.2	2.7
Social time	0.1	0.2	0.5	-0.7	0.1	0.1
Soleus weight	0.8	2.4	3.6	-1.9	1.4	-1.4
Bone: stiffness	19.7	32.0	34.0	-5.8	5.6	-5.5
Tibialis anterior weight	1.8	6.1	8.4	-2.9	1.6	-2.7
Time to tail flick, vehicle, before self-admin	1.6	1.7	2.3	1.1	-1.2	1.5
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.8	-0.9	0.3	-0.3
Time to tail flick, test, before self-admin	0.4	0.4	0.8	0.4	-0.4	0.9
Time to tail flick, test, after self-admin	0.9	0.9	1.2	-1.1	0.9	-0.9
Delta time to tail flick, vehicle, before/after SA	0.7	0.6	0.9	-0.9	0.7	-0.8
Delta time to tail flick, test, before/after SA	0.4	0.4	0.5	-0.6	0.5	-0.7
Tibia length	7.0	19.2	24.2	-3.5	4.6	-4.9
Ambulatory time before self-admin	2.1	3.1	3.7	1.9	-1.6	1.8
Ambulatory time after self-admin	1.7	2.0	3.0	1.7	-1.2	1.2
Bone: tissue strength	1.2	1.2	1.5	-1.2	1.2	-0.9
Total heroin consumption	0.8	1.0	1.1	-0.8	1.0	-1.0
Bone: trabecular number	5.4	8.9	10.8	-2.5	3.3	-3.1
Bone: trabecular spacing	2.1	2.8	3.5	1.4	-1.9	1.7
Bone: trabecular thickness	0.1	0.1	0.1	-0.2	-0.3	0.3
Bone: trabecular tissue density	0.0	0.0	0.1	-0.3	-0.1	0.1
Water consumed over 24 hours	0.1	0.1	0.1	0.4	0.3	-0.1
Number of responses in last shaping day	0.1	0.1	0.2	0.3	-0.4	-0.1