Hub : Genes

Proser3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye gene expression Proser3 0.35 0.2 9.4e-03 0.01 0.01 0 0 2.2e-01 2.4e-01 3.1e-01 2.8e-01
2 OFC isoform ratio XM_063266455.1 0.2 0.17 8.9e-03 0.1 0.04 0.05 0.1 1.8e-03 4.7e-02 2.9e-02 2.7e-03
3 Liver gene expression Proser3 0.17 0.09 0.0e+00 0.15 0.14 0.14 0.14 1.2e-16 1.4e-15 1.5e-15 1.2e-15
4 IL gene expression Proser3 0.57 0.16 1.1e-06 0.17 0.19 0.21 0.21 7.2e-05 2.4e-05 7.4e-06 1.1e-05
5 Adipose gene expression Proser3 0.04 0.03 4.3e-04 0.01 0.01 0.01 0.01 2.1e-02 7.2e-03 1.8e-02 2.0e-02
6 PL mRNA stability Proser3 0.03 0.03 9.0e-03 0.01 0.01 0.01 0.01 1.0e-02 2.0e-02 2.1e-02 9.4e-03
7 OFC gene expression Proser3 0.35 0.2 4.1e-04 0.09 0.11 0.02 0.07 3.8e-03 1.8e-03 9.4e-02 1.2e-02
8 Brain gene expression Proser3 0.34 0.13 0.0e+00 0.35 0.38 0.39 0.39 4.0e-34 2.9e-37 3.3e-38 2.0e-38
9 NAcc gene expression Proser3 0.08 0.04 7.5e-10 0.06 0.06 0.06 0.06 1.8e-09 3.9e-09 9.4e-10 1.0e-09
10 LHb gene expression Proser3 0.28 0.14 2.6e-05 0.24 0.18 0.19 0.22 2.3e-06 3.8e-05 2.4e-05 7.3e-06
11 IC gene expression Proser3 0.22 0.11 2.5e-05 0.08 0.07 0.06 0.09 3.1e-04 7.0e-04 1.7e-03 1.7e-04
12 PL gene expression Proser3 0.25 0.1 0.0e+00 0.19 0.2 0.21 0.21 8.7e-21 2.3e-21 3.8e-22 2.9e-22
13 BLA gene expression Proser3 0.29 0.11 4.5e-09 0.13 0.16 0.16 0.15 2.8e-07 4.4e-09 1.2e-08 1.6e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.91.52.41.1-0.81.2-1.11.40.21.51.21.41.51.51.51.1
Area under the delay curve0.50.61.40.7-0.70.30.3-0.0-1.2-0.6-0.7-0.8-0.8-0.9-0.9-1.1
BMI with tail0.20.61.2-0.50.5-0.30.2-0.8-0.4-0.7-0.9-1.0-1.0-1.0-1.1-1.0
BMI without tail0.10.41.21.0-1.00.7-0.40.4-1.1-0.00.0-0.3-0.3-0.4-0.4-0.7
Body weight1.98.316.03.8-3.84.01.13.7-2.03.12.82.62.52.52.41.4
Weight adjusted by age0.10.10.30.20.20.5-0.60.4-0.20.50.30.40.40.40.40.1
Bone surface0.81.43.21.8-1.51.8-1.01.4-1.31.00.80.91.01.01.00.2
Bone volume1.01.83.81.7-1.52.0-0.91.7-1.01.41.11.21.31.31.30.5
Breakpoint value in progressive ratio session0.50.63.11.1-1.80.80.30.6-1.1-0.00.1-0.2-0.4-0.4-0.3-0.5
Number of licking bursts2.44.05.9-2.32.4-1.70.3-2.4-0.2-2.2-2.2-2.2-2.1-2.1-2.2-1.8
Context. condit. distance diff. score0.50.71.3-0.20.10.20.5-0.5-1.1-0.7-1.0-1.0-0.9-1.0-1.0-1.1
Locomotion velocity, session 10.40.40.9-0.90.6-0.5-0.7-0.20.90.50.40.60.60.60.70.6
Locomotion distance, session 10.60.85.60.6-0.80.9-2.40.4-1.20.2-0.3-0.10.00.00.1-0.7
Locomotion velocity, session 20.80.96.7-0.60.6-1.1-2.6-0.90.9-0.8-0.5-0.4-0.3-0.3-0.3-0.2
Locomotion distance, session 22.53.515.8-1.41.2-1.2-4.0-1.8-0.4-1.7-1.7-1.7-1.8-1.7-1.7-1.9
Locomotion velocity, session 30.50.65.9-0.50.7-0.4-2.4-0.50.2-0.4-0.4-0.3-0.3-0.3-0.3-0.4
Locomotion distance, session 32.12.36.72.0-1.91.6-2.60.7-2.6-0.5-0.7-0.7-0.7-0.7-0.7-1.7
Stereotopy head waving bouts, day 31.01.14.9-0.60.7-1.10.70.02.20.71.00.90.90.90.91.6
Stereotopy head waving duration, day 31.11.46.5-1.21.2-1.61.0-0.42.50.40.80.70.60.70.61.5
Locomotion velocity, session 70.50.62.80.6-0.60.7-1.70.1-1.3-0.3-0.4-0.4-0.5-0.5-0.5-0.9
Locomotion distance, session 70.50.65.20.5-0.40.8-2.30.5-0.60.40.40.40.30.30.4-0.1
Stereotopy head waving bouts, day 71.92.13.0-1.41.4-1.4-0.8-1.70.0-1.7-1.7-1.7-1.6-1.6-1.7-1.3
Stereotopy head waving duration, day 71.51.83.0-1.61.6-1.70.3-1.70.8-1.3-1.3-1.4-1.3-1.2-1.4-0.7
Locomotion velocity, session 83.74.56.0-2.32.2-1.9-2.4-2.40.1-2.2-2.3-2.2-2.2-2.2-2.2-1.9
Locomotion distance, session 82.43.46.3-1.11.1-0.6-2.5-1.7-1.4-1.9-2.1-2.1-2.1-2.1-2.0-2.4
Degree of sensitization distance0.90.92.3-0.90.9-0.31.50.11.20.80.90.91.00.91.01.3
Degree of sensitization stereotypy2.42.63.9-1.21.3-1.1-0.6-1.7-0.7-1.9-2.0-2.0-1.9-1.8-1.9-1.8
Conditioned locomotion0.70.81.2-0.70.5-1.00.2-1.10.1-1.1-1.1-1.1-1.1-1.1-1.1-0.9
Cocaine response after cond. corrected0.70.92.0-0.10.2-0.51.10.41.40.90.80.91.01.01.11.4
Cocaine response after cond. not corrected1.51.84.00.00.1-0.21.50.81.61.21.31.51.61.61.72.0
Cocaine response before conditioning1.01.22.01.2-1.21.40.41.3-0.60.81.01.11.21.21.20.7
Saline control response0.10.10.5-0.20.2-0.30.3-0.00.70.30.30.40.40.40.40.6
Bone: connectivity density0.40.64.70.8-0.60.5-2.20.6-0.00.40.30.40.50.50.50.2
Bone: cortical apparent density0.81.03.3-1.81.5-1.1-0.5-1.30.5-0.7-0.9-0.9-0.8-0.8-0.9-0.7
Bone: cortical area1.42.23.31.7-1.41.80.61.8-0.71.61.71.51.51.51.51.1
Bone: cortical porosity2.93.15.5-0.71.1-1.3-0.8-1.7-0.6-2.3-2.3-2.2-2.1-2.1-2.1-1.9
Bone: cortical porosity3.74.06.8-1.01.3-1.5-0.7-2.1-0.7-2.6-2.6-2.4-2.4-2.4-2.4-2.2
Bone: cortical thickness0.81.42.31.0-0.81.20.61.30.01.51.51.31.31.31.31.1
Bone: cortical thickness0.20.20.7-0.80.8-0.70.7-0.50.80.10.20.0-0.0-0.0-0.10.3
Bone: cortical tissue density1.01.33.6-1.91.6-1.2-0.6-1.40.4-0.9-1.1-1.1-1.0-1.0-1.0-0.9
Condit. Reinf. active minus inactive responses0.10.20.3-0.60.4-0.6-0.2-0.50.2-0.4-0.4-0.4-0.4-0.4-0.4-0.2
Condit. Reinf. active-inactive response ratio0.40.41.8-0.30.4-0.7-0.10.01.30.40.60.60.50.50.50.9
Condit. Reinf. active responses1.82.23.5-1.81.4-1.8-0.4-1.90.3-1.5-1.8-1.6-1.6-1.6-1.5-1.3
Condit. Reinf. inactive responses3.23.96.7-1.91.4-1.6-0.6-2.3-0.7-2.2-2.6-2.4-2.2-2.3-2.2-2.2
Incentive salience index mean0.30.40.6-0.50.3-0.7-0.6-0.7-0.0-0.7-0.7-0.7-0.7-0.7-0.6-0.6
Condit. Reinf. lever presses0.40.51.0-0.0-0.1-0.4-0.6-0.6-0.5-0.9-1.0-0.8-0.9-0.9-0.7-0.9
Condit. Reinf. active minus inactive responses0.60.82.61.4-1.60.9-1.21.0-0.20.50.60.70.70.70.70.4
Condit. Reinf. active-inactive response ratio0.00.00.2-0.40.2-0.20.2-0.10.40.0-0.1-0.00.00.0-0.00.1
Condit. Reinf. active responses1.52.16.12.4-2.51.8-1.91.7-1.10.70.80.91.01.01.00.2
Condit. Reinf. inactive responses1.72.27.32.7-2.61.9-1.91.4-2.00.00.20.30.30.30.3-0.6
Condit. Reinf. lever presses3.85.312.43.5-3.52.9-0.52.9-1.51.92.02.02.02.02.11.1
Condit. Reinf. lever reinforcers received1.62.26.52.4-2.52.0-2.11.7-1.50.60.60.70.80.80.8-0.0
Conditioned reinforcement - actives0.20.41.7-1.31.1-0.8-0.9-0.70.7-0.3-0.1-0.2-0.1-0.1-0.20.2
Conditioned reinforcement - inactives1.72.64.80.3-0.5-0.1-1.8-0.9-1.6-1.9-1.9-1.9-1.9-1.9-1.9-2.2
Conditioned locomotion1.62.04.1-2.01.7-1.7-0.9-1.80.8-1.4-1.3-1.4-1.4-1.4-1.4-0.7
Patch foraging indifference point 0 sec0.10.10.60.8-0.4-0.2-0.50.10.0-0.4-0.3-0.2-0.1-0.1-0.1-0.1
Patch foraging indifference point AUC0.40.51.4-0.71.2-1.1-0.5-0.90.8-0.6-0.7-0.6-0.6-0.6-0.6-0.2
Delay disc. indifference point, 0s delay1.51.74.7-0.1-0.50.51.0-0.6-2.2-0.8-1.5-1.5-1.5-1.5-1.5-2.0
Delay disc. indifference point, 16s delay0.80.91.91.1-1.00.30.6-0.0-1.4-0.8-0.8-0.9-1.0-1.0-1.0-1.2
Delay disc. indifference point, 2s delay0.50.62.70.9-1.21.10.00.4-1.7-0.0-0.3-0.3-0.4-0.4-0.4-1.0
Delay disc. indifference point, 24s delay0.70.83.31.7-1.81.1-0.20.9-1.40.10.0-0.1-0.1-0.1-0.1-0.5
Delay disc. indifference point, 4s delay0.70.71.30.00.2-0.3-0.8-0.7-0.6-1.1-1.0-1.0-1.0-1.0-1.1-1.1
Delay disc. indifference point, 8s delay0.10.10.30.6-0.30.30.20.2-0.5-0.1-0.0-0.1-0.1-0.2-0.2-0.2
Indifference point function ln k0.20.31.00.4-1.00.7-0.50.6-0.30.50.70.50.40.40.40.2
Indifference point function log k0.20.31.00.4-1.00.7-0.50.6-0.30.50.70.50.40.40.40.2
Patch foraging total patch changes 0 sec0.10.10.80.9-0.5-0.0-0.70.2-0.1-0.4-0.3-0.1-0.0-0.0-0.0-0.1
Patch foraging total patch changes 12 sec0.10.20.80.40.1-0.7-0.9-0.00.9-0.2-0.10.10.10.10.20.4
Patch foraging total patch changes 18 sec0.20.40.80.00.6-0.3-0.5-0.5-0.1-0.8-0.9-0.8-0.7-0.7-0.6-0.7
Patch foraging total patch changes 24 sec0.30.41.91.1-0.50.90.80.5-1.4-0.0-0.4-0.2-0.1-0.1-0.1-0.6
Patch foraging total patch changes 6 sec0.10.21.50.7-0.0-0.4-1.20.10.6-0.3-0.10.10.10.10.20.3
Patch foraging time to switch 0 sec0.20.51.5-1.01.0-1.01.1-0.61.2-0.3-0.1-0.00.00.0-0.00.5
Patch foraging water rate 0 sec0.40.81.7-0.60.6-1.1-1.3-1.00.2-1.0-0.9-0.9-1.0-1.0-0.9-0.8
Patch foraging water rate 12 sec0.40.86.00.8-0.81.2-2.40.5-1.3-0.1-0.0-0.10.00.0-0.1-0.5
Patch foraging water rate 18 sec0.10.22.3-0.40.0-0.3-1.5-0.30.1-0.4-0.2-0.2-0.1-0.1-0.2-0.1
Patch foraging water rate 24 sec2.33.211.8-0.10.10.1-3.4-1.0-1.8-1.7-1.7-1.8-1.9-1.9-2.0-2.4
Patch foraging water rate 6 sec0.91.35.51.2-1.31.2-2.30.4-1.9-0.4-0.6-0.6-0.4-0.4-0.5-1.2
Seeking ratio, delayed vs. immediate footshock0.91.26.01.2-0.71.40.40.4-2.5-0.3-0.9-0.7-0.7-0.8-0.8-1.3
Distance traveled before self-admin0.00.10.5-0.1-0.70.2-0.1-0.0-0.3-0.2-0.1-0.0-0.0-0.0-0.1-0.2
Distance traveled after self-admin1.31.64.11.6-2.01.6-0.31.5-0.71.01.21.21.21.21.20.7
Extensor digitorum longus weight0.52.013.7-0.81.0-0.33.70.21.31.51.30.90.90.90.81.3
Bone: elastic displacement0.30.41.5-0.00.00.21.20.40.60.50.70.70.70.70.70.8
Bone: elastic work1.41.82.61.5-1.41.61.61.6-0.61.41.41.31.31.31.20.9
Bone: endosteal estimation1.02.14.22.0-2.01.90.51.8-1.21.21.41.31.31.31.30.8
Bone: endosteal perimeter0.61.33.61.7-1.91.7-0.41.3-1.60.60.80.70.70.70.60.1
Epididymis fat weight0.00.10.4-0.10.20.5-0.40.30.00.60.50.30.20.20.20.1
Delta time in closed arm before/after self-admin0.80.81.51.2-1.21.10.91.0-0.90.90.70.80.70.70.70.3
Delta time in open arm before/after self-admin0.40.41.9-0.40.8-0.7-1.4-0.41.2-0.4-0.3-0.10.10.10.10.2
Diff in mean of infusions in LGA sessions1.11.32.5-0.70.2-1.20.7-1.2-0.1-1.3-1.0-1.4-1.6-1.6-1.6-1.1
Delay discount exponential model param0.40.41.2-0.90.8-0.4-0.2-0.11.10.40.40.60.60.70.70.8
Extinction: sum of active levers before priming4.14.56.51.9-2.32.11.62.5-0.12.52.52.42.22.22.31.9
Active lever presses in extinction session 65.04.97.71.2-1.81.01.72.11.32.42.72.72.72.72.72.8
Bone: final force1.01.73.21.8-1.61.61.11.7-0.91.41.21.11.11.11.10.6
Bone: final moment1.52.54.32.1-1.82.01.52.0-1.01.71.51.41.41.41.30.8
Food consumed during 24 hour testing period0.50.72.81.0-1.00.8-0.70.2-1.7-0.6-0.4-0.5-0.6-0.6-0.6-1.1
Glucose0.40.72.1-0.70.6-0.2-0.10.11.50.70.80.91.00.90.91.2
Heart weight0.30.41.60.3-0.60.1-1.3-0.2-0.6-0.7-0.5-0.6-0.6-0.6-0.7-0.7
Delay discount hyperbolic model param0.40.41.0-0.70.7-0.3-0.2-0.01.00.50.50.60.70.70.80.9
Intermittent access intake day 1-15 change1.12.25.81.3-1.61.92.41.7-1.31.61.41.21.21.21.10.6
Intermittent access intake escalation1.12.25.61.0-1.31.82.41.7-1.01.71.51.41.41.41.30.9
Intermittent access intake escalation 21.61.83.70.9-1.21.31.91.5-0.21.41.51.41.51.51.41.1
Intermitt. access day 1 inactive lever presses0.51.86.82.6-2.61.7-0.71.3-2.1-0.1-0.1-0.1-0.2-0.2-0.1-0.9
Intermitt. access day 15 inactive lever presses0.81.74.11.3-1.30.6-0.5-0.0-2.0-1.2-1.3-1.4-1.4-1.3-1.4-1.7
Intermitt. access escalation Index0.60.81.5-0.60.4-0.10.4-0.8-0.8-1.0-1.1-1.2-1.0-1.0-1.0-1.2
Intermittent access day 1 total infusions2.94.66.4-1.81.8-1.3-1.6-2.3-0.7-2.5-2.5-2.5-2.5-2.5-2.5-2.3
Intermittent access day 15 total infusions0.50.81.6-0.60.40.30.5-0.6-1.3-0.7-0.9-1.1-1.0-1.0-1.1-1.2
Intermittent access terminal intake (last 3 days)1.41.93.2-1.00.6-0.30.0-1.2-1.2-1.6-1.6-1.7-1.7-1.7-1.7-1.8
Intermittent access total infusions1.72.13.2-1.20.9-0.4-0.3-1.4-1.1-1.6-1.7-1.8-1.8-1.8-1.8-1.8
Intermittent access day 1 locomotion4.45.68.8-1.21.0-1.1-2.1-2.2-1.4-2.8-2.8-2.9-3.0-3.0-2.9-2.9
Intermittent access day 15 total locomotion0.81.52.8-0.4-0.20.1-0.8-0.8-1.5-1.3-1.3-1.5-1.5-1.5-1.5-1.7
Intermittent access total locomotion2.42.94.4-1.51.1-1.1-0.9-1.8-0.7-2.0-2.0-2.0-2.1-2.1-2.1-1.9
Intermittent access standard deviation0.91.84.92.0-2.22.11.11.5-2.20.70.50.30.40.40.3-0.3
Left kidney weight1.78.013.83.1-2.73.71.33.5-1.43.32.92.93.03.02.81.8
Right kidney weight2.511.216.33.5-3.14.01.04.0-1.03.93.73.73.73.73.62.5
Cocaine induced anxiety0.00.00.10.1-0.0-0.00.20.20.30.40.30.20.10.10.20.3
Post-drug Anxiety0.20.20.4-0.10.1-0.50.3-0.40.1-0.4-0.6-0.5-0.6-0.6-0.5-0.5
Baseline Anxiety0.70.81.70.2-0.0-0.20.2-0.6-0.8-1.2-1.3-1.1-1.1-1.1-1.1-1.3
Tail length2.911.520.74.5-4.54.50.04.3-2.43.43.53.13.03.03.01.7
Length with tail4.118.033.85.7-5.85.6-0.05.4-2.74.14.13.93.93.93.82.2
Length without tail2.16.912.23.3-3.43.50.53.3-1.52.82.52.52.52.52.51.5
Times rat made contact with spout0.80.91.8-1.01.2-0.11.30.01.00.90.80.80.90.90.91.0
Lifetime Intake1.21.42.0-1.41.1-0.6-0.6-1.3-0.6-1.3-1.3-1.4-1.4-1.4-1.4-1.3
Liver weight, left0.20.31.1-0.91.1-0.80.4-0.70.8-0.3-0.5-0.3-0.2-0.2-0.20.1
Liver weight, right0.30.52.9-0.70.6-0.8-1.7-0.41.40.00.20.20.30.30.20.6
Locomotor activity0.91.45.8-0.50.5-0.9-0.80.02.40.61.01.11.21.21.21.7
Locomotor testing distance0.40.73.3-0.81.0-0.90.0-0.31.80.20.50.70.70.70.71.2
Locomotor testing rearing0.51.04.3-1.72.1-1.4-0.3-1.21.3-0.5-0.5-0.2-0.3-0.3-0.20.1
Locomotion in novel chamber0.20.21.2-0.4-0.3-0.9-0.3-0.31.1-0.10.30.10.10.10.00.5
Locomotion in novel chamber post-restriction0.10.10.5-0.1-0.3-0.70.5-0.30.3-0.4-0.2-0.2-0.2-0.2-0.20.0
Fecal boli incidents, locomotor time 11.31.85.4-2.11.1-2.3-0.4-1.71.9-1.2-0.7-0.9-1.1-1.1-1.0-0.1
Change in fecal boli incidents, locomotor task1.21.22.60.40.0-0.11.10.71.31.11.31.21.31.31.21.6
Time >=10cm from walls, locomotor time 10.00.00.1-0.20.3-0.20.2-0.10.3-0.0-0.3-0.2-0.1-0.1-0.10.1
Bouts of movement, locomotor time 11.01.23.90.6-1.00.8-1.3-0.1-2.0-0.8-0.9-0.9-0.9-0.9-0.9-1.5
Total resting periods, locomotor time 10.70.82.80.4-1.00.6-0.9-0.1-1.7-0.7-0.7-0.8-0.9-0.9-0.9-1.3
Rest time, locomotor task time 11.11.33.6-1.40.6-1.90.2-1.51.1-1.2-1.0-1.1-1.2-1.2-1.2-0.4
Distance moved, locomotor task time 10.10.10.50.30.40.6-0.10.2-0.70.20.30.10.00.00.0-0.2
Vertical activity count, locomotor time 10.51.13.51.9-1.31.6-0.61.2-1.50.50.70.60.70.70.6-0.2
Time >=10cm from walls, locomotor time 21.01.52.6-1.31.1-1.6-1.0-1.50.8-1.3-1.1-1.2-1.3-1.3-1.3-0.7
Bouts of movement, locomotor time 20.10.22.4-0.20.00.2-1.6-0.1-0.1-0.2-0.1-0.1-0.0-0.00.0-0.2
Total resting periods, locomotor time 20.10.22.8-0.20.0-0.1-1.7-0.30.2-0.4-0.1-0.1-0.1-0.1-0.0-0.1
Rest time, locomotor task time 20.30.31.3-0.5-0.1-1.1-0.0-0.70.8-0.7-0.3-0.5-0.5-0.5-0.50.0
Distance moved, locomotor task time 20.30.31.2-0.11.10.2-0.8-0.3-0.8-0.2-0.3-0.4-0.5-0.5-0.5-0.8
Vertical activity count, locomotor time 20.40.52.11.1-0.51.1-0.80.6-1.50.10.10.10.10.10.0-0.6
Light reinforcement 10.20.51.3-0.30.5-0.2-1.1-0.6-0.1-0.8-0.7-0.7-0.7-0.7-0.7-0.8
Light reinforcement 21.21.83.7-1.91.6-1.9-1.1-1.71.4-1.2-1.1-1.1-1.1-1.1-1.1-0.7
Bone: marrow area1.02.34.32.1-2.11.90.71.8-1.21.31.51.41.41.41.40.9
Bone: maximum diameter0.91.63.11.7-1.61.81.01.6-1.11.21.31.11.11.11.00.7
Bone: maximum force1.52.75.62.4-2.12.30.72.2-1.41.71.51.41.41.41.30.7
Bone: maximum moment2.03.56.62.6-2.32.50.92.4-1.51.91.71.61.61.61.60.9
Mean time between licks in bursts0.30.62.20.2-0.1-0.2-1.5-0.4-0.9-0.9-0.7-0.8-0.8-0.8-0.8-1.0
Mean num. licks in bursts2.43.75.91.2-1.41.40.42.00.72.42.42.42.32.32.32.1
Cd content in liver0.20.21.6-0.60.5-0.21.3-0.20.00.10.0-0.0-0.1-0.1-0.10.1
Co content in liver0.20.21.2-0.40.6-0.80.6-0.31.1-0.00.10.10.00.00.10.5
Cu content in liver0.60.71.61.3-1.01.10.11.1-0.80.90.80.80.70.70.70.3
Fe content in liver0.20.20.8-0.50.5-0.90.2-0.60.7-0.4-0.3-0.2-0.3-0.3-0.30.0
K content in liver0.10.10.20.5-0.3-0.2-0.50.10.2-0.20.00.0-0.0-0.0-0.00.1
Mg content in liver0.40.42.6-0.30.5-1.2-0.4-0.21.6-0.00.40.40.30.30.30.8
Mn content in liver0.70.83.7-0.70.5-1.11.0-0.21.90.20.60.70.70.70.71.3
Na content in liver0.40.41.01.0-0.80.90.70.8-0.80.20.40.30.40.40.30.2
Rb content in liver0.60.72.3-0.40.3-0.61.5-0.6-0.3-0.7-0.9-0.9-1.0-1.0-1.0-0.7
Se content in liver2.32.78.5-2.42.5-2.8-1.2-1.82.9-0.8-0.5-0.4-0.4-0.4-0.40.5
Sr content in liver0.20.20.8-0.10.2-0.60.4-0.10.9-0.10.20.30.30.30.30.7
Zn content in liver0.91.03.5-1.01.6-1.90.6-1.11.9-0.4-0.2-0.3-0.4-0.4-0.40.3
Bone: minimum diameter1.32.47.02.6-2.62.4-0.51.7-2.50.60.70.70.60.60.6-0.3
Time in familiar zone, hab. session 12.22.14.00.6-0.50.90.91.40.72.01.91.81.71.81.81.7
Time in novel zone, hab. session 13.33.35.8-1.01.1-1.6-1.7-1.9-0.4-2.4-1.8-2.1-2.2-2.2-2.2-1.9
Total zone transitions, hab. session 10.30.41.1-0.20.00.1-0.4-0.5-1.0-0.6-0.7-0.6-0.6-0.6-0.6-1.0
Total locomotion distance, hab. session 10.50.62.51.3-1.60.7-1.50.6-0.9-0.20.00.20.30.30.4-0.1
Locomotion velocity, hab. session 10.30.41.61.0-1.30.5-1.00.6-0.30.00.20.40.60.60.60.3
Time in familiar zone, hab. session 22.02.13.21.7-1.80.91.11.60.61.31.71.61.41.41.51.6
Time in novel zone, hab. session 20.90.92.0-1.41.4-0.8-1.0-1.1-0.0-0.7-0.9-0.8-0.8-0.8-0.8-0.9
Total zone transitions, hab. session 22.93.77.2-2.02.0-2.1-2.7-2.30.4-2.0-1.9-1.8-1.8-1.8-1.8-1.5
Total locomotion distance, hab. session 21.11.44.5-0.20.1-0.8-2.1-1.0-0.6-1.6-1.4-1.3-1.2-1.2-1.2-1.2
Locomotion velocity, hab. session 20.81.13.4-0.30.2-0.9-1.8-1.0-0.3-1.4-1.2-1.1-1.1-1.0-1.0-1.0
Novel to familiar place preference ratio0.10.10.40.4-0.20.40.10.1-0.6-0.2-0.3-0.2-0.1-0.1-0.1-0.3
Novelty place preference0.10.10.50.3-0.10.30.10.0-0.7-0.3-0.4-0.3-0.2-0.2-0.2-0.4
Time in novel zone, NPP test0.10.10.40.00.10.20.1-0.2-0.7-0.5-0.6-0.4-0.3-0.3-0.4-0.6
Total zone transitions, NPP test0.30.55.7-0.40.1-0.0-2.4-0.2-0.00.1-0.20.00.10.10.1-0.3
Total locomotion distance, NPP test1.72.34.31.8-2.11.7-1.81.7-0.71.21.21.51.61.61.60.8
Locomotion velocity, NPP test1.82.54.91.9-2.21.7-1.81.8-0.51.21.31.51.51.61.61.0
Intraocular pressure0.40.53.7-0.4-0.1-0.11.9-0.4-0.5-0.6-0.7-0.6-0.6-0.6-0.6-0.7
Delta distance traveled before/after self-admin1.51.63.61.9-1.41.7-0.31.7-0.71.31.21.21.21.21.30.7
Delta ambulatory time before/after self-admin1.21.43.41.9-1.51.8-0.21.6-1.01.11.01.01.01.01.00.5
Parametrial fat weight1.22.96.7-0.20.3-0.61.40.92.41.81.91.92.02.02.02.6
Pavlov. Cond. lever latency0.81.07.20.1-0.10.62.70.7-0.11.11.00.80.70.70.60.7
Pavlov. Cond. magazine entry latency1.31.715.5-0.91.0-1.1-3.9-1.00.9-1.0-0.3-0.3-0.3-0.3-0.3-0.1
Pavlov. Cond. change in total contacts2.52.614.0-0.50.6-0.9-3.7-1.3-0.6-1.8-1.6-1.5-1.5-1.5-1.4-1.6
Pavlov. Cond. index score1.41.816.2-0.60.8-1.1-4.0-1.00.6-1.2-0.7-0.6-0.6-0.6-0.5-0.4
Pavlov. Cond. latency score1.21.613.8-0.40.5-0.9-3.7-0.90.3-1.2-0.8-0.7-0.7-0.7-0.6-0.6
Pavlov. Cond. lever contacts0.60.75.80.3-0.2-0.3-2.4-0.3-0.1-0.9-0.7-0.5-0.5-0.4-0.4-0.5
Pavlov. Cond. magazine entry number1.31.614.80.8-0.91.03.81.0-0.51.10.60.50.60.50.50.5
Pavlov. Cond. intertrial magazine entries0.40.51.3-1.10.7-0.81.0-0.80.5-0.3-0.7-0.6-0.5-0.5-0.5-0.3
Pavlov. Cond. lever-magazine prob. diff.1.82.217.8-0.81.0-1.3-4.2-1.20.7-1.4-0.8-0.8-0.8-0.7-0.7-0.6
Pavlov. Cond. response bias0.91.111.6-0.50.6-0.8-3.4-0.51.0-0.60.00.10.10.10.20.3
Pavlov. Cond. lever latency2.12.87.4-2.72.7-2.50.4-2.11.9-1.1-1.0-1.1-1.2-1.2-1.1-0.2
Pavlov. Cond. magazine entry latency1.41.75.32.1-2.31.70.21.6-1.20.70.90.90.90.90.90.3
Pavlov. Cond. change in total contacts2.94.711.93.3-3.43.31.12.7-2.91.41.21.31.31.31.30.1
Pavlov. Cond. index score2.53.48.52.8-2.92.70.32.3-1.91.31.31.31.41.41.40.4
Pavlov. Cond. latency score2.12.77.62.7-2.82.40.22.1-1.81.01.01.11.11.11.10.2
Pavlov. Cond. lever contacts2.33.17.92.8-2.82.7-0.12.2-2.11.21.11.11.21.21.20.1
Pavlov. Cond. magazine entry number2.22.75.6-2.22.3-2.4-0.5-2.11.5-1.4-1.4-1.4-1.4-1.4-1.5-0.6
Pavlov. Cond. intertrial magazine entries0.50.72.0-1.01.4-1.01.1-1.00.4-0.6-0.7-0.7-0.7-0.7-0.7-0.3
Pavlov. Cond. lever-magazine prob. diff.2.53.37.72.7-2.82.60.32.3-1.71.41.31.41.51.51.50.6
Pavlov. Cond. response bias2.73.69.03.0-3.03.0-0.12.4-2.41.31.21.21.31.31.20.1
Time in closed arm before self-admin1.82.33.9-1.62.0-1.1-0.5-1.7-0.2-1.6-1.9-1.8-1.6-1.6-1.6-1.5
Time in closed arm after self-admin0.80.81.90.0-0.1-0.00.3-0.6-1.2-0.8-1.2-1.1-1.1-1.1-1.1-1.4
Time in open arm before self-admin3.94.36.42.3-2.52.00.72.5-0.42.12.52.32.22.22.21.9
Time in open arm after self-admin1.61.82.71.3-1.01.0-0.31.50.51.31.61.61.61.61.61.6
Bone: periosteal estimation1.63.45.82.4-2.22.40.62.3-1.21.82.01.81.81.81.71.1
Bone: periosteal perimeter1.01.73.11.6-1.81.60.21.6-0.71.21.41.31.31.31.31.0
Bone: post-yield work0.91.34.61.9-1.81.7-0.61.1-2.10.10.0-0.0-0.0-0.0-0.0-0.7
Progressive ratio test 1 active lever presses0.70.91.7-0.30.00.2-0.5-0.6-1.3-1.0-1.0-1.2-1.1-1.1-1.1-1.3
Progressive ratio test 1 breakpoint0.80.91.9-0.2-0.00.3-0.5-0.6-1.4-1.1-1.1-1.2-1.1-1.2-1.2-1.4
Progressive ratio test 1 inactive lever presses2.84.18.10.1-0.50.1-1.8-1.1-2.3-2.2-2.5-2.4-2.5-2.4-2.3-2.9
Progressive ratio test 2 active lever presses0.30.31.5-1.20.7-0.10.6-0.6-0.4-0.3-0.3-0.5-0.5-0.5-0.6-0.5
Progressive ratio test 2 breakpoint0.40.51.8-1.30.9-0.20.6-0.7-0.4-0.4-0.4-0.6-0.6-0.6-0.7-0.5
Progressive ratio test 2 inactive lever presses1.62.55.60.1-0.80.30.1-0.7-2.1-1.5-1.8-2.0-2.0-2.0-2.1-2.4
Incentive Sensitization - Responses0.30.42.1-1.40.9-0.40.7-0.7-0.1-0.2-0.4-0.5-0.6-0.6-0.7-0.4
Incentive Sensitization - Breakpoint0.30.52.0-1.40.9-0.40.7-0.7-0.1-0.2-0.4-0.5-0.6-0.6-0.7-0.5
Sum of active levers in priming session hrs 5-60.10.10.9-0.30.0-0.20.9-0.10.20.20.30.0-0.1-0.1-0.10.2
Progressive ratio0.20.31.1-0.1-0.1-0.4-1.0-0.50.1-0.9-0.6-0.6-0.5-0.6-0.5-0.4
Food seeking constrained by brief footshock1.11.45.02.0-2.21.4-0.31.4-0.80.60.80.80.80.80.90.5
Seeking ratio, punishment vs. effort0.20.21.01.0-0.60.70.00.6-0.80.30.10.20.10.20.2-0.2
Retroperitoneal fat weight1.35.316.1-1.21.3-1.30.10.54.02.02.52.42.62.62.53.5
Reaction time number correct0.10.21.1-0.2-0.20.0-1.00.20.20.40.30.30.30.30.40.3
Reaction time mean minus median0.20.61.21.0-0.40.81.10.9-0.50.80.80.70.70.70.70.5
Reaction time mean minus median AUC0.51.32.01.4-0.71.31.21.4-0.61.31.31.21.21.21.10.9
Reaction time num false alarms0.60.91.6-1.31.3-1.01.1-1.00.3-0.8-0.9-0.8-0.9-0.9-0.8-0.5
Reaction time num false alarms AUC0.61.02.1-1.41.4-1.30.9-1.20.5-1.0-1.0-0.9-0.9-0.9-0.8-0.4
Reaction time trials correct on left0.10.21.1-0.2-0.20.0-1.00.20.20.40.30.30.30.30.40.3
Reaction time trials on left0.10.21.0-0.1-0.20.1-1.00.20.20.40.30.40.40.40.40.3
Reaction time mean0.10.20.80.3-0.10.90.50.5-0.70.50.50.40.30.30.30.1
Reaction time mean AUC0.10.20.50.30.00.70.30.5-0.50.50.50.40.30.30.30.2
Median of all reaction times0.00.00.3-0.20.20.5-0.10.1-0.50.10.1-0.0-0.0-0.0-0.1-0.2
Reaction time omissions0.30.51.00.10.20.10.50.50.60.70.80.90.80.80.81.0
Reaction time false alarm rate0.71.02.3-1.11.2-1.01.5-1.00.1-1.0-1.0-0.9-1.0-1.0-0.9-0.6
Reaction time premature initiation rate0.60.91.80.4-0.4-0.1-1.0-0.6-0.9-1.3-1.1-1.1-1.1-1.1-1.1-1.1
Reaction time premature initiations0.40.72.50.3-0.5-0.2-1.6-0.5-0.7-1.1-0.9-0.9-0.9-0.9-0.9-1.0
Std. dev. reaction times0.40.71.81.0-0.51.31.30.9-1.30.70.70.60.50.50.50.1
Reaction time trials completed0.10.21.0-0.1-0.20.1-1.00.20.20.40.30.40.40.40.40.3
Reaction time trials AUC0.20.30.8-0.3-0.1-0.0-0.90.30.50.60.50.60.60.60.60.6
Run reversals in cocaine runway, females0.40.41.60.8-0.71.3-0.20.6-1.20.40.20.00.10.1-0.0-0.4
Run reversals in cocaine runway, males2.82.86.5-0.00.2-0.5-0.30.92.41.61.92.02.02.02.12.6
Latency to leave start box in cocaine runway0.30.31.60.5-0.30.80.30.1-1.3-0.1-0.6-0.4-0.4-0.4-0.4-0.9
Latency to leave start box in cocaine runway, F0.50.61.60.20.10.3-0.6-0.3-0.9-0.6-1.0-0.8-0.8-0.9-0.8-1.3
Latency to leave start box in cocaine runway, M0.20.21.30.2-0.10.51.20.1-0.70.1-0.1-0.1-0.1-0.1-0.0-0.2
Std. dev. time between licks in bursts1.72.34.70.8-0.8-0.5-2.2-0.8-1.3-2.1-1.6-1.7-1.6-1.6-1.6-1.8
Total sessions with >9 infusions0.60.83.3-1.41.5-0.9-1.8-0.80.8-0.4-0.3-0.2-0.2-0.2-0.20.1
Short access day 1 total inactive lever presses2.83.78.00.3-0.90.7-1.7-0.7-2.7-1.7-2.1-2.2-2.2-2.2-2.2-2.8
Short access day 10 total inactive lever presses0.81.95.61.8-2.31.4-0.10.5-2.4-0.6-1.1-0.9-1.0-0.9-0.8-1.9
Short access day 1 total infusions0.30.42.0-0.20.4-0.0-1.4-0.4-0.4-0.5-0.6-0.6-0.6-0.6-0.6-0.6
Short access day 10 total infusions0.30.31.0-1.01.0-0.4-0.4-0.7-0.0-0.5-0.5-0.5-0.4-0.4-0.4-0.3
Short access total infusions0.50.61.7-1.31.3-0.7-1.2-0.90.3-0.6-0.5-0.5-0.5-0.5-0.5-0.2
Short access day 1 locomotion0.60.81.7-1.31.3-0.9-0.4-1.00.3-0.8-0.7-0.9-1.0-1.0-1.0-0.5
Short access day 10 total locomotion0.71.45.30.7-0.80.2-2.3-0.3-1.2-1.4-1.1-1.2-1.1-1.1-1.1-1.3
Short access total locomotion1.61.93.6-1.31.3-1.3-1.9-1.50.2-1.6-1.4-1.5-1.4-1.4-1.4-1.0
One hour access (0.3 mA shock)1.11.34.70.4-0.70.9-0.7-0.2-2.2-1.0-0.9-1.3-1.1-1.2-1.4-1.6
Compulsive drug intake0.91.12.80.3-0.3-0.1-1.7-0.6-1.0-1.3-1.2-1.2-1.1-1.1-1.1-1.3
One hour access (shock baseline)0.20.41.0-0.50.20.20.1-0.4-1.0-0.5-0.5-0.7-0.7-0.7-0.8-0.8
Social response proportion0.70.83.41.5-1.81.00.51.1-0.90.60.80.50.30.30.20.1
Social responses0.30.32.21.2-1.50.10.40.5-0.3-0.10.20.20.00.0-0.00.0
Social time1.01.44.21.8-2.01.80.61.3-2.00.50.50.30.20.20.2-0.4
Soleus weight0.10.32.2-0.00.3-0.31.50.00.60.40.40.30.40.40.30.5
Bone: stiffness0.71.12.51.6-1.41.40.21.4-1.11.10.80.80.80.80.80.2
Tibialis anterior weight0.93.019.1-0.40.60.24.40.71.22.01.71.41.41.51.31.8
Time to tail flick, vehicle, before self-admin0.30.40.6-0.50.8-0.4-0.8-0.6-0.2-0.6-0.8-0.6-0.5-0.5-0.6-0.5
Time to tail flick, vehicle, after self-admin0.10.11.00.4-1.0-0.00.70.2-0.1-0.20.00.00.10.10.10.2
Time to tail flick, test, before self-admin1.21.33.4-0.40.60.5-0.1-0.7-1.8-0.8-1.4-1.3-1.2-1.2-1.3-1.9
Time to tail flick, test, after self-admin0.20.20.9-0.50.1-0.4-0.9-0.40.4-0.3-0.3-0.3-0.3-0.3-0.3-0.2
Delta time to tail flick, vehicle, before/after SA0.30.31.40.9-1.20.50.20.6-0.30.20.30.40.40.40.40.3
Delta time to tail flick, test, before/after SA1.01.04.9-0.5-0.1-1.1-0.70.02.20.40.90.80.80.80.91.6
Tibia length1.64.39.42.6-2.43.1-0.72.6-1.72.21.91.91.91.91.90.8
Ambulatory time before self-admin0.10.10.70.1-0.90.1-0.3-0.1-0.3-0.4-0.2-0.2-0.2-0.2-0.3-0.4
Ambulatory time after self-admin2.02.47.92.2-2.82.1-0.71.9-1.31.01.21.21.11.11.10.3
Bone: tissue strength1.11.14.11.8-1.61.60.21.1-2.00.3-0.1-0.1-0.1-0.1-0.1-0.7
Total heroin consumption0.40.40.90.5-0.80.5-0.50.0-0.8-0.4-0.5-0.6-0.8-0.8-0.7-1.0
Bone: trabecular number0.81.32.51.6-1.31.5-1.31.4-0.81.10.80.91.01.01.00.4
Bone: trabecular spacing0.50.61.10.7-0.80.31.00.80.50.40.80.80.90.90.81.1
Bone: trabecular thickness0.10.10.5-0.40.70.3-0.2-0.0-0.20.4-0.1-0.00.00.00.0-0.2
Bone: trabecular tissue density1.62.46.2-1.91.7-1.12.1-0.32.51.11.11.21.31.31.22.0
Water consumed over 24 hours0.50.71.10.8-0.71.00.30.9-0.21.01.11.00.90.90.90.6
Number of responses in last shaping day0.10.11.0-0.0-0.10.5-1.00.0-0.7-0.2-0.0-0.2-0.1-0.1-0.1-0.3