Hub : Genes

Proser3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC mRNA stability Proser3 0.31 0.19 9.8e-03 0.05 0.03 0.05 0.04 2.7e-02 7.3e-02 2.3e-02 5.0e-02
2 Liver gene expression Proser3 0.17 0.08 0.0e+00 0.16 0.15 0.14 0.15 3.0e-17 1.7e-16 8.6e-16 2.3e-16
3 Adipose gene expression Proser3 0.03 0.02 6.9e-04 0.01 0.01 0.01 0.01 6.8e-02 8.3e-03 4.3e-02 5.2e-02
4 OFC gene expression Proser3 0.27 0.15 9.4e-04 0.06 0.04 0.01 0.04 1.8e-02 4.7e-02 2.2e-01 5.1e-02
5 LHb alternative TSS XM_008759168.3 0.85 0.09 4.7e-03 0.02 0.05 0.11 0.14 1.0e-01 2.7e-02 1.2e-03 2.9e-04
6 LHb alternative TSS XM_008759168.3 0.85 0.08 4.9e-03 0.02 0.05 0.12 0.13 1.1e-01 2.5e-02 9.6e-04 6.1e-04
7 IL gene expression Proser3 0.58 0.17 2.8e-06 0.19 0.16 0.19 0.2 2.4e-05 1.0e-04 2.7e-05 1.4e-05
8 Brain gene expression Proser3 0.34 0.13 0.0e+00 0.37 0.34 0.37 0.37 2.2e-36 2.0e-32 4.6e-36 6.6e-36
9 NAcc gene expression Proser3 0.07 0.04 8.9e-07 0.06 0.06 0.06 0.06 1.8e-07 1.3e-07 1.1e-07 1.2e-07
10 pVTA gene expression Proser3 0.23 0.12 1.8e-06 0.12 0.13 0.09 0.14 6.0e-06 3.7e-06 1.4e-04 8.0e-07
11 PL mRNA stability Proser3 0.06 0.04 3.3e-04 0.04 0.03 0.03 0.04 3.0e-05 2.1e-04 1.1e-04 5.1e-05
12 LHb gene expression Proser3 0.3 0.15 2.7e-05 0.24 0.19 0.2 0.22 2.1e-06 2.8e-05 1.3e-05 7.6e-06
13 PL gene expression Proser3 0.27 0.11 0.0e+00 0.2 0.2 0.21 0.21 6.0e-22 5.4e-22 2.7e-22 1.7e-22
14 Adipose isoform ratio XM_039081899.1 0.05 0.04 7.9e-03 0.01 0.02 0.02 0.01 1.8e-02 4.8e-03 3.3e-03 8.5e-03
15 BLA gene expression Proser3 0.33 0.12 9.5e-10 0.15 0.18 0.18 0.18 1.5e-08 3.4e-10 4.1e-10 5.6e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.01.63.00.4-1.21.5-1.4-0.3-0.31.3-1.5-1.61.7-0.4-1.61.7-1.01.4
Area under the delay curve0.70.71.61.0-0.1-0.10.2-1.0-1.0-0.40.60.9-1.01.00.9-1.01.3-1.1
BMI with tail0.10.51.1-0.10.7-0.90.7-0.1-0.2-0.61.10.8-0.9-0.30.9-0.90.2-0.8
BMI without tail0.00.10.20.2-0.10.30.1-0.1-0.1-0.0-0.2-0.40.2-0.4-0.20.3-0.50.3
Body weight1.66.614.22.4-3.83.6-2.4-2.4-2.32.0-2.9-2.82.81.4-2.92.7-0.41.6
Weight adjusted by age0.20.20.80.2-0.60.5-0.3-0.3-0.40.2-0.9-0.40.50.2-0.50.4-0.00.3
Bone surface0.81.43.31.7-1.81.5-0.9-1.6-1.60.4-0.9-0.91.01.2-0.91.00.40.3
Bone volume1.01.63.71.5-1.91.7-1.2-1.4-1.40.8-1.3-1.21.40.9-1.31.40.00.7
Breakpoint value in progressive ratio session0.60.71.71.2-0.70.5-0.1-1.3-1.2-0.20.10.5-0.51.10.6-0.61.0-0.9
Number of licking bursts2.63.15.50.01.7-2.31.8-0.1-0.2-2.02.22.3-2.20.22.2-2.21.4-1.9
Context. condit. distance diff. score0.60.71.40.4-0.1-0.50.6-0.7-0.8-0.81.01.0-1.01.10.9-1.01.2-1.2
Locomotion velocity, session 10.40.51.3-0.70.5-0.2-0.30.80.80.4-0.6-0.60.5-1.2-0.50.6-0.80.9
Locomotion distance, session 10.70.93.51.9-1.00.40.3-1.8-1.8-0.6-0.00.1-0.01.20.0-0.11.1-0.5
Locomotion velocity, session 20.30.31.1-0.01.1-0.90.80.30.3-0.70.40.3-0.4-0.80.4-0.3-0.00.0
Locomotion distance, session 21.72.43.61.31.2-1.71.9-1.3-1.4-1.91.51.7-1.70.31.7-1.71.3-1.6
Locomotion velocity, session 30.20.20.90.50.4-0.50.8-0.4-0.4-0.90.30.2-0.3-0.20.3-0.30.3-0.2
Locomotion distance, session 33.23.510.13.1-1.60.70.5-3.2-3.2-1.20.80.7-0.72.50.6-0.82.4-1.6
Stereotopy head waving bouts, day 31.92.35.4-2.01.1-0.1-0.82.22.21.2-0.8-0.90.9-2.3-0.91.0-2.21.6
Stereotopy head waving duration, day 32.32.76.6-2.41.6-0.5-0.82.62.61.2-0.7-0.70.6-2.6-0.60.7-2.41.5
Locomotion velocity, session 70.90.92.81.5-0.70.10.3-1.7-1.7-0.60.60.4-0.51.30.5-0.51.3-0.9
Locomotion distance, session 70.30.31.21.0-0.70.40.2-1.1-1.1-0.3-0.3-0.30.30.6-0.30.30.5-0.0
Stereotopy head waving bouts, day 71.51.73.40.21.1-1.51.80.0-0.1-1.81.61.6-1.60.11.5-1.51.0-1.3
Stereotopy head waving duration, day 71.21.53.1-1.01.8-1.81.21.00.9-1.11.51.3-1.4-0.81.3-1.30.1-0.8
Locomotion velocity, session 82.83.36.1-0.42.0-2.52.20.20.1-2.02.32.3-2.3-0.12.3-2.31.2-1.8
Locomotion distance, session 82.53.65.81.30.7-1.72.2-1.5-1.6-2.42.02.1-2.11.32.1-2.22.2-2.3
Degree of sensitization distance1.31.33.0-1.70.40.0-0.61.71.71.0-1.0-0.90.9-1.2-0.80.9-1.41.3
Degree of sensitization stereotypy2.52.75.30.41.1-1.72.3-0.3-0.4-2.32.11.9-2.00.51.9-2.01.6-1.8
Conditioned locomotion0.60.71.3-0.41.1-1.10.60.30.3-0.41.11.1-1.1-0.21.1-1.10.2-0.8
Cocaine response after cond. corrected1.51.73.2-1.80.50.4-1.41.61.61.6-0.9-1.01.1-1.5-1.01.1-1.61.4
Cocaine response after cond. not corrected2.73.04.5-2.00.30.7-1.52.12.11.8-1.5-1.61.7-2.0-1.61.7-2.12.1
Cocaine response before conditioning0.60.81.70.9-1.31.30.1-0.3-0.2-0.1-1.1-1.11.20.5-1.11.10.10.9
Saline control response0.20.30.6-0.40.00.2-0.30.40.40.5-0.7-0.80.6-0.5-0.60.6-0.70.7
Bone: connectivity density0.20.30.60.6-0.60.7-0.4-0.5-0.50.4-0.6-0.60.8-0.2-0.60.8-0.30.5
Bone: cortical apparent density0.81.02.5-0.41.3-1.60.80.0-0.1-0.71.31.2-1.3-0.31.3-1.30.4-1.0
Bone: cortical area0.81.22.30.7-1.51.5-1.3-0.7-0.61.2-1.4-1.21.20.6-1.31.2-0.20.9
Bone: cortical porosity2.73.05.30.51.6-1.92.2-0.2-0.3-1.92.22.3-2.20.22.0-2.11.8-1.8
Bone: cortical porosity3.43.76.60.61.7-2.22.3-0.4-0.4-2.02.52.6-2.40.42.2-2.42.0-2.0
Bone: cortical thickness0.50.81.5-0.1-0.71.0-1.10.00.01.2-1.2-1.11.1-0.3-1.11.1-0.71.0
Bone: cortical thickness0.40.41.2-1.00.8-0.5-0.60.90.90.6-0.2-0.20.1-1.1-0.30.2-1.00.6
Bone: cortical tissue density0.91.23.0-0.51.4-1.70.90.0-0.0-0.81.41.3-1.4-0.31.5-1.40.5-1.1
Condit. Reinf. active minus inactive responses0.10.10.30.10.6-0.50.2-0.1-0.1-0.10.30.5-0.5-0.30.4-0.5-0.0-0.3
Condit. Reinf. active-inactive response ratio0.70.82.2-1.10.8-0.0-0.91.01.01.2-0.7-0.50.4-1.4-0.50.5-1.50.9
Condit. Reinf. active responses1.31.63.4-0.21.8-1.80.9-0.0-0.1-0.91.61.7-1.7-0.41.6-1.60.5-1.2
Condit. Reinf. inactive responses2.83.36.20.51.6-2.21.6-0.7-0.8-1.82.52.4-2.20.62.3-2.21.7-2.1
Incentive salience index mean0.30.30.80.40.7-0.70.3-0.4-0.4-0.40.70.9-0.8-0.10.7-0.80.3-0.6
Condit. Reinf. lever presses0.40.51.00.70.3-0.50.1-0.7-0.6-0.40.91.0-0.90.50.8-0.90.9-0.9
Condit. Reinf. active minus inactive responses0.40.51.21.0-1.01.1-0.4-0.9-0.80.3-0.5-0.60.70.6-0.70.70.20.3
Condit. Reinf. active-inactive response ratio0.00.00.1-0.40.1-0.1-0.20.20.20.20.20.2-0.0-0.1-0.00.00.00.1
Condit. Reinf. active responses1.11.54.12.0-1.91.7-0.3-1.7-1.60.0-0.8-0.91.01.4-0.90.90.70.2
Condit. Reinf. inactive responses1.62.06.92.6-1.91.50.4-2.2-2.1-0.8-0.3-0.40.32.0-0.20.21.6-0.6
Condit. Reinf. lever presses2.83.88.82.1-2.93.0-1.5-1.7-1.61.1-2.0-2.12.21.3-2.22.1-0.11.2
Condit. Reinf. lever reinforcers received1.31.95.72.4-2.11.7-0.0-2.1-2.0-0.3-0.5-0.60.71.8-0.70.71.2-0.1
Conditioned reinforcement - actives0.20.20.80.30.2-0.50.90.0-0.0-0.80.70.5-0.2-0.10.2-0.20.6-0.1
Conditioned reinforcement - inactives3.74.27.22.5-0.4-0.62.0-2.1-2.1-2.32.02.1-1.92.21.9-2.02.7-2.4
Conditioned locomotion2.42.95.90.11.6-2.21.8-0.0-0.1-1.62.42.3-2.20.02.1-2.21.4-1.8
Patch foraging indifference point 0 sec0.10.20.70.50.00.00.9-0.3-0.3-0.80.40.2-0.20.20.3-0.20.5-0.3
Patch foraging indifference point AUC0.20.30.8-0.90.7-0.4-0.20.90.80.20.20.1-0.1-0.90.0-0.0-0.40.3
Delay disc. indifference point, 0s delay2.62.95.51.7-0.3-0.70.7-2.0-2.0-1.11.61.8-1.82.11.7-1.82.3-2.2
Delay disc. indifference point, 16s delay0.80.81.71.1-0.20.00.1-1.0-1.0-0.40.90.9-1.01.20.9-1.01.3-1.2
Delay disc. indifference point, 2s delay1.31.44.11.9-1.10.40.0-2.0-2.0-0.40.50.5-0.61.80.5-0.71.5-1.2
Delay disc. indifference point, 24s delay1.00.92.51.5-1.10.9-0.5-1.5-1.50.1-0.10.1-0.01.60.2-0.11.3-0.7
Delay disc. indifference point, 4s delay0.91.01.60.90.5-0.81.2-0.6-0.6-1.21.01.3-1.10.41.2-1.21.2-1.1
Delay disc. indifference point, 8s delay0.10.10.50.6-0.30.20.1-0.5-0.4-0.2-0.10.2-0.20.60.2-0.20.7-0.3
Indifference point function ln k0.20.31.01.0-0.70.60.1-0.9-0.8-0.2-0.7-0.50.30.5-0.50.3-0.10.1
Indifference point function log k0.20.31.01.0-0.70.60.1-0.9-0.8-0.2-0.7-0.50.30.5-0.50.3-0.10.1
Patch foraging total patch changes 0 sec0.10.20.70.6-0.20.10.8-0.5-0.4-0.80.30.2-0.10.40.2-0.20.6-0.3
Patch foraging total patch changes 12 sec0.10.20.6-0.50.6-0.1-0.10.70.80.20.1-0.00.1-0.8-0.10.1-0.20.4
Patch foraging total patch changes 18 sec0.30.41.10.4-0.1-0.30.7-0.4-0.4-0.90.90.7-0.50.50.6-0.61.1-0.6
Patch foraging total patch changes 24 sec0.70.92.31.3-1.10.60.2-1.4-1.4-0.50.40.3-0.11.50.2-0.21.4-0.7
Patch foraging total patch changes 6 sec0.00.10.2-0.20.20.10.50.40.4-0.40.0-0.00.2-0.40.00.10.00.1
Patch foraging time to switch 0 sec0.71.13.6-1.91.2-0.6-0.61.81.81.0-0.0-0.10.1-1.30.00.1-0.90.6
Patch foraging water rate 0 sec0.50.81.80.41.0-1.11.4-0.3-0.3-1.30.91.0-1.1-0.31.0-1.10.3-0.8
Patch foraging water rate 12 sec0.81.24.52.1-1.30.51.4-1.5-1.4-1.50.10.10.01.2-0.1-0.01.1-0.4
Patch foraging water rate 18 sec0.20.21.00.50.5-0.51.0-0.1-0.1-1.00.30.3-0.4-0.20.3-0.30.0-0.1
Patch foraging water rate 24 sec3.34.79.22.8-0.3-0.92.7-2.5-2.6-3.01.61.9-2.01.91.8-2.02.3-2.3
Patch foraging water rate 6 sec1.62.48.02.8-1.30.51.3-2.4-2.4-1.70.50.5-0.52.00.5-0.61.7-1.2
Seeking ratio, delayed vs. immediate footshock1.51.85.22.1-1.20.40.4-1.9-1.9-0.70.30.6-0.62.30.5-0.61.9-1.2
Distance traveled before self-admin0.00.00.1-0.0-0.1-0.00.10.10.1-0.1-0.3-0.30.3-0.2-0.30.3-0.10.2
Distance traveled after self-admin1.21.44.21.7-2.11.7-0.4-1.5-1.4-0.0-0.9-0.91.01.2-0.91.00.60.2
Extensor digitorum longus weight0.52.06.3-1.70.20.3-2.31.11.12.5-1.2-1.10.9-1.3-1.11.0-2.01.3
Bone: elastic displacement0.30.40.7-0.5-0.10.3-0.20.70.70.2-0.8-0.60.7-0.6-0.80.7-0.60.8
Bone: elastic work1.01.22.60.7-1.51.6-1.2-0.5-0.51.0-1.5-1.31.30.5-1.41.3-0.20.9
Bone: endosteal estimation0.61.33.31.6-1.81.7-0.5-1.3-1.30.2-1.1-1.01.01.4-1.00.90.40.4
Bone: endosteal perimeter0.61.23.01.7-1.71.3-0.4-1.6-1.50.0-0.6-0.40.51.7-0.50.40.9-0.1
Epididymis fat weight0.20.41.71.2-0.70.40.1-1.3-1.3-0.3-0.10.00.00.5-0.20.10.4-0.2
Delta time in closed arm before/after self-admin1.71.73.30.7-1.71.8-1.7-0.9-0.81.4-1.7-1.41.40.9-1.41.3-0.10.8
Delta time in open arm before/after self-admin0.50.51.5-0.80.8-0.60.71.01.0-0.50.70.2-0.1-1.20.1-0.1-0.50.2
Diff in mean of infusions in LGA sessions1.21.32.8-0.11.0-1.21.1-0.3-0.3-1.01.21.5-1.60.31.7-1.70.8-1.4
Delay discount exponential model param0.50.51.2-1.00.2-0.1-0.10.90.90.2-0.3-0.60.7-0.9-0.70.7-1.10.9
Extinction: sum of active levers before priming2.42.44.70.4-1.92.1-2.2-0.5-0.41.9-2.0-1.71.90.3-1.71.8-0.81.2
Active lever presses in extinction session 64.74.67.5-0.9-1.42.3-2.70.91.12.7-2.7-2.62.6-0.9-2.62.6-1.62.5
Bone: final force0.61.02.31.2-1.51.5-0.7-1.3-1.30.6-0.9-0.80.90.9-0.80.80.30.2
Bone: final moment0.81.33.21.3-1.81.8-0.9-1.3-1.30.8-1.1-1.01.10.9-1.11.10.20.4
Food consumed during 24 hour testing period1.01.23.11.8-0.80.30.6-1.7-1.7-1.00.20.5-0.51.60.5-0.61.5-1.0
Glucose0.40.71.1-1.00.10.1-0.71.01.00.7-0.7-0.80.7-1.0-0.80.7-0.91.0
Heart weight0.50.61.31.0-0.5-0.00.7-1.0-0.9-0.80.60.7-0.71.10.6-0.71.1-1.0
Delay discount hyperbolic model param0.60.61.3-1.00.20.0-0.11.01.00.3-0.5-0.70.8-1.0-0.80.8-1.21.0
Intermittent access intake day 1-15 change1.21.23.41.0-1.81.6-1.1-1.0-1.00.7-1.0-1.11.01.3-1.00.90.30.4
Intermittent access intake escalation1.11.13.31.2-1.81.5-0.9-1.3-1.30.6-0.7-0.90.71.5-0.70.70.60.1
Intermittent access intake escalation 20.80.81.90.5-1.41.4-0.9-0.5-0.40.7-1.0-1.11.00.6-1.11.0-0.10.7
Intermitt. access day 1 inactive lever presses0.70.82.30.9-1.31.5-1.0-0.9-0.80.7-1.0-0.70.61.0-0.60.50.30.1
Intermitt. access day 15 inactive lever presses0.80.81.60.9-0.2-0.10.2-0.9-0.9-0.40.81.0-1.11.21.1-1.11.2-1.3
Intermitt. access escalation Index1.11.02.30.80.1-0.71.4-0.8-0.8-1.41.50.9-1.00.70.9-0.90.9-1.1
Intermittent access day 1 total infusions4.24.98.60.91.4-2.42.9-0.7-0.8-2.82.92.8-2.60.82.6-2.62.1-2.4
Intermittent access day 15 total infusions3.43.86.52.0-0.1-1.12.2-1.8-1.8-2.42.32.0-1.91.91.9-2.02.5-2.3
Intermittent access terminal intake (last 3 days)3.74.17.11.80.4-1.42.6-1.4-1.5-2.72.62.2-2.11.52.1-2.22.3-2.3
Intermittent access total infusions4.04.48.41.70.5-1.72.9-1.3-1.4-2.92.72.4-2.21.42.2-2.22.4-2.3
Intermittent access day 1 locomotion4.85.17.91.41.1-2.02.6-1.3-1.3-2.62.82.8-2.71.22.7-2.72.3-2.6
Intermittent access day 15 total locomotion3.53.86.12.0-0.1-1.02.2-1.8-1.8-2.42.02.0-2.01.92.0-2.02.5-2.3
Intermittent access total locomotion3.23.76.01.01.2-1.92.5-0.8-0.9-2.42.42.4-2.30.72.3-2.31.9-2.1
Intermittent access standard deviation2.22.36.02.5-2.31.6-0.1-2.2-2.2-0.40.1-0.20.32.5-0.40.31.8-0.6
Left kidney weight2.98.114.50.5-3.23.6-3.8-0.8-0.73.6-3.6-3.43.50.2-3.53.4-1.62.6
Right kidney weight3.710.519.21.4-4.04.4-3.8-1.4-1.33.4-4.1-4.04.00.8-4.03.9-1.52.8
Cocaine induced anxiety0.40.51.7-0.3-0.50.8-1.30.10.11.2-0.6-0.70.7-0.0-0.70.7-0.40.5
Post-drug Anxiety0.50.61.7-1.30.7-0.1-1.01.11.11.10.1-0.00.0-0.8-0.00.1-0.70.3
Baseline Anxiety1.01.11.9-0.51.4-1.41.10.50.5-0.91.31.3-1.4-0.31.3-1.30.4-0.9
Tail length2.57.516.02.0-3.74.0-2.6-1.6-1.42.2-3.4-3.23.31.1-3.43.3-0.72.3
Length with tail3.814.031.83.6-5.65.5-3.4-3.4-3.22.6-4.3-3.94.12.7-4.23.90.12.3
Length without tail2.65.714.82.8-3.93.4-1.8-2.9-2.81.1-2.2-2.12.22.4-2.32.10.70.8
Times rat made contact with spout0.70.81.8-1.10.20.0-0.61.11.00.7-0.9-0.90.9-1.1-0.90.9-1.31.2
Lifetime Intake2.32.65.81.10.6-1.52.4-0.8-0.9-2.42.11.9-1.70.91.7-1.71.7-1.7
Liver weight, left0.71.12.4-1.40.6-0.1-1.21.21.21.3-0.4-0.70.6-1.6-0.80.7-1.51.1
Liver weight, right0.30.52.5-0.40.7-0.1-0.30.60.60.3-0.4-0.60.6-1.6-0.70.6-1.10.9
Locomotor activity1.32.15.5-1.60.8-0.0-0.21.92.00.6-1.1-1.31.3-2.3-1.21.3-2.21.8
Locomotor testing distance0.61.12.6-1.10.6-0.20.31.51.50.1-0.7-0.90.9-1.6-0.80.9-1.41.3
Locomotor testing rearing0.50.71.8-0.91.2-1.31.41.01.0-0.90.40.2-0.3-1.30.3-0.2-0.60.2
Locomotion in novel chamber0.40.41.4-1.21.0-0.40.11.11.10.2-0.10.0-0.1-1.00.0-0.1-0.80.3
Locomotion in novel chamber post-restriction0.10.10.4-0.50.5-0.1-0.10.60.60.2-0.0-0.1-0.0-0.20.2-0.1-0.50.1
Fecal boli incidents, locomotor time 11.31.44.0-1.72.0-1.40.31.71.70.10.21.0-0.8-1.70.9-0.7-0.5-0.0
Change in fecal boli incidents, locomotor task1.61.52.7-1.2-0.00.8-1.51.21.31.6-1.2-1.31.1-1.1-1.11.2-1.61.4
Time >=10cm from walls, locomotor time 10.10.10.1-0.40.3-0.0-0.30.30.30.30.2-0.0-0.0-0.30.00.1-0.20.2
Bouts of movement, locomotor time 11.61.83.81.9-0.7-0.11.1-1.8-1.8-1.40.61.0-0.91.70.9-1.01.9-1.5
Total resting periods, locomotor time 11.11.22.71.6-0.5-0.10.9-1.5-1.5-1.20.50.9-0.81.40.8-0.91.6-1.2
Rest time, locomotor task time 10.70.82.3-1.31.5-1.1-0.21.21.30.40.20.7-0.8-1.20.8-0.7-0.5-0.2
Distance moved, locomotor task time 10.30.30.90.7-0.70.30.4-0.9-1.0-0.5-0.4-0.30.10.9-0.00.00.3-0.1
Vertical activity count, locomotor time 11.01.12.61.6-1.61.20.1-1.5-1.5-0.4-0.6-0.70.61.5-0.60.50.7-0.1
Time >=10cm from walls, locomotor time 21.01.12.8-0.81.7-1.51.00.70.6-0.80.71.3-1.2-0.81.3-1.20.2-0.7
Bouts of movement, locomotor time 20.20.21.10.7-0.2-0.21.0-0.4-0.4-1.10.30.3-0.10.30.1-0.10.5-0.3
Total resting periods, locomotor time 20.20.21.20.30.1-0.31.10.0-0.0-1.00.30.3-0.1-0.10.1-0.10.3-0.1
Rest time, locomotor task time 20.40.51.4-0.91.2-0.70.41.11.2-0.10.30.6-0.5-1.00.5-0.4-0.30.1
Distance moved, locomotor task time 20.40.51.41.0-0.3-0.30.7-1.1-1.2-0.90.00.4-0.50.90.5-0.60.7-0.7
Vertical activity count, locomotor time 20.91.03.11.6-1.20.6-0.0-1.7-1.7-0.4-0.3-0.10.11.5-0.0-0.01.1-0.6
Light reinforcement 10.40.82.40.90.2-0.71.6-0.6-0.6-1.40.90.8-0.80.30.8-0.80.8-0.8
Light reinforcement 21.01.34.1-0.82.0-1.81.00.70.7-0.61.21.0-1.2-1.21.3-1.2-0.5-0.7
Bone: marrow area0.61.33.41.5-1.81.7-0.6-1.2-1.20.4-1.2-1.11.11.4-1.11.00.30.5
Bone: maximum diameter0.61.22.80.8-1.61.6-1.7-0.7-0.71.3-1.2-1.01.01.0-1.11.00.00.6
Bone: maximum force1.11.94.31.8-2.11.9-1.0-1.9-1.90.7-1.1-1.01.11.3-1.11.10.50.3
Bone: maximum moment1.32.25.31.9-2.32.1-1.1-1.9-1.90.8-1.3-1.21.31.4-1.31.20.50.4
Mean time between licks in bursts0.30.41.50.60.4-0.41.2-0.5-0.5-1.10.70.6-0.70.20.7-0.70.4-0.7
Mean num. licks in bursts2.93.56.1-0.5-1.32.0-1.90.50.62.1-2.4-2.52.4-0.8-2.42.4-1.92.2
Cd content in liver0.20.30.4-0.4-0.60.5-0.40.50.50.5-0.6-0.50.6-0.0-0.60.6-0.00.6
Co content in liver0.20.20.8-0.90.7-0.5-0.20.70.60.30.30.2-0.3-0.60.3-0.3-0.6-0.1
Cu content in liver0.30.31.10.6-0.80.7-1.0-0.6-0.60.6-0.2-0.30.30.7-0.30.30.2-0.0
Fe content in liver0.10.10.2-0.40.2-0.30.00.40.4-0.10.40.4-0.40.10.4-0.40.4-0.2
K content in liver0.10.10.20.30.4-0.10.1-0.00.0-0.40.30.3-0.3-0.10.3-0.30.1-0.1
Mg content in liver0.40.41.5-0.71.2-0.70.10.80.8-0.10.40.4-0.4-1.10.4-0.3-0.70.1
Mn content in liver1.11.23.5-1.61.4-0.70.01.91.90.4-0.1-0.10.1-1.8-0.20.2-1.30.9
Na content in liver0.70.72.21.5-1.20.7-0.3-1.2-1.2-0.2-0.00.0-0.01.50.0-0.11.2-0.5
Rb content in liver0.70.81.80.10.6-0.70.0-0.4-0.4-0.41.31.2-1.30.71.3-1.30.7-1.3
Se content in liver2.73.310.8-2.53.3-2.60.42.22.10.01.51.3-1.4-2.41.4-1.3-1.1-0.3
Sr content in liver0.60.51.7-1.21.0-0.60.61.31.3-0.1-0.00.10.0-1.1-0.00.1-0.50.5
Zn content in liver0.10.10.3-0.30.5-0.3-0.30.20.20.30.40.4-0.4-0.20.4-0.4-0.1-0.3
Bone: minimum diameter1.22.26.12.5-2.21.7-0.4-2.2-2.1-0.1-0.6-0.40.52.4-0.40.41.6-0.4
Time in familiar zone, hab. session 12.52.45.0-0.7-0.91.3-2.20.30.32.2-1.9-1.91.8-0.7-1.81.7-1.71.6
Time in novel zone, hab. session 13.33.28.20.41.6-1.92.9-0.0-0.1-2.71.92.1-2.10.32.1-2.11.5-1.7
Total zone transitions, hab. session 10.50.71.30.9-0.0-0.50.9-0.9-0.9-1.00.70.7-0.70.70.7-0.81.1-0.9
Total locomotion distance, hab. session 10.30.41.71.3-0.70.60.8-0.7-0.6-0.9-0.10.10.20.6-0.20.20.9-0.0
Locomotion velocity, hab. session 10.10.20.50.7-0.50.60.4-0.1-0.1-0.4-0.4-0.20.50.2-0.40.40.40.4
Time in familiar zone, hab. session 21.71.72.8-0.9-0.91.6-1.51.01.11.6-1.7-1.51.4-0.3-1.41.4-1.31.4
Time in novel zone, hab. session 20.50.51.30.40.8-1.10.9-0.4-0.5-0.90.90.8-0.8-0.20.8-0.70.6-0.6
Total zone transitions, hab. session 21.82.45.1-0.12.1-2.32.20.20.1-2.01.51.8-1.8-0.71.8-1.80.5-1.2
Total locomotion distance, hab. session 21.01.33.20.80.8-1.01.8-0.4-0.4-1.81.11.3-1.20.41.3-1.21.0-1.1
Locomotion velocity, hab. session 20.70.92.70.50.9-1.01.7-0.1-0.2-1.60.91.1-1.00.11.1-1.10.7-0.9
Novel to familiar place preference ratio0.20.20.40.6-0.40.10.5-0.6-0.6-0.70.40.3-0.30.70.3-0.30.6-0.5
Novelty place preference0.30.30.80.6-0.3-0.00.8-0.6-0.6-0.90.50.4-0.40.80.4-0.40.8-0.6
Time in novel zone, NPP test0.40.41.10.6-0.2-0.21.0-0.6-0.6-1.00.70.6-0.60.70.5-0.60.8-0.7
Total zone transitions, NPP test0.10.10.50.70.1-0.20.4-0.6-0.7-0.5-0.00.1-0.1-0.10.0-0.10.2-0.1
Total locomotion distance, NPP test0.91.32.71.4-1.61.6-0.4-0.9-0.80.1-1.3-1.21.40.5-1.41.4-0.00.9
Locomotion velocity, NPP test0.91.33.01.3-1.61.7-0.5-0.7-0.60.3-1.4-1.31.50.4-1.51.5-0.21.1
Intraocular pressure0.30.41.3-0.10.0-0.41.0-0.1-0.2-1.10.60.7-0.70.60.9-0.80.6-0.8
Delta distance traveled before/after self-admin1.51.65.01.7-2.22.0-0.8-1.7-1.60.4-0.8-0.90.91.5-0.90.90.60.1
Delta ambulatory time before/after self-admin1.92.15.92.1-2.42.1-0.7-2.0-1.90.2-0.8-0.80.91.9-0.90.90.90.1
Parametrial fat weight3.66.913.5-2.50.41.2-2.82.32.33.2-2.3-2.72.7-3.0-2.62.8-3.73.2
Pavlov. Cond. lever latency0.40.61.7-0.5-0.80.8-1.30.10.11.2-0.8-0.90.70.3-0.70.7-0.60.5
Pavlov. Cond. magazine entry latency0.50.63.60.60.9-0.81.90.10.1-1.70.00.4-0.2-0.80.2-0.2-0.10.2
Pavlov. Cond. change in total contacts2.32.57.51.50.8-1.32.7-1.1-1.1-2.71.41.6-1.50.51.5-1.51.6-1.4
Pavlov. Cond. index score0.60.83.50.61.2-1.11.90.10.1-1.70.50.7-0.6-0.80.6-0.60.2-0.2
Pavlov. Cond. latency score0.60.83.10.71.0-0.91.8-0.2-0.2-1.60.60.8-0.7-0.50.7-0.70.4-0.4
Pavlov. Cond. lever contacts0.30.31.10.70.5-0.41.1-0.3-0.3-1.00.50.6-0.5-0.10.5-0.50.5-0.4
Pavlov. Cond. magazine entry number0.70.84.3-0.8-1.01.0-2.10.10.11.9-0.3-0.60.50.7-0.50.5-0.10.1
Pavlov. Cond. intertrial magazine entries0.20.30.6-0.70.8-0.8-0.20.10.10.30.70.6-0.6-0.40.5-0.5-0.1-0.4
Pavlov. Cond. lever-magazine prob. diff.0.81.04.40.61.3-1.22.10.0-0.0-1.90.60.9-0.8-0.70.8-0.80.3-0.3
Pavlov. Cond. response bias0.30.31.70.40.7-0.51.30.20.2-1.1-0.20.00.1-1.0-0.10.1-0.40.5
Pavlov. Cond. lever latency2.02.66.3-2.52.5-2.21.02.32.2-0.41.01.2-1.3-1.81.2-1.2-0.7-0.3
Pavlov. Cond. magazine entry latency0.60.72.01.2-1.41.4-0.7-0.8-0.80.2-0.6-0.70.81.0-0.70.70.40.3
Pavlov. Cond. change in total contacts3.04.211.23.1-3.42.6-1.1-2.9-2.80.4-0.9-1.11.22.9-1.11.11.5-0.2
Pavlov. Cond. index score1.82.36.02.3-2.42.1-1.0-1.9-1.90.3-1.0-1.11.21.8-1.21.10.90.3
Pavlov. Cond. latency score1.62.05.12.2-2.32.0-1.0-1.9-1.80.3-0.8-1.01.11.8-1.01.00.90.2
Pavlov. Cond. lever contacts1.92.66.62.6-2.52.0-0.8-2.3-2.30.3-0.9-1.01.12.0-1.01.01.00.1
Pavlov. Cond. magazine entry number1.61.95.2-1.82.3-2.01.11.51.5-0.51.11.2-1.3-1.61.3-1.2-0.6-0.5
Pavlov. Cond. intertrial magazine entries0.40.62.0-1.41.0-0.80.21.11.10.20.50.5-0.5-0.80.6-0.5-0.4-0.2
Pavlov. Cond. lever-magazine prob. diff.1.82.25.92.1-2.42.2-1.1-1.7-1.60.5-1.1-1.31.41.7-1.31.30.60.5
Pavlov. Cond. response bias2.22.98.02.8-2.72.1-0.7-2.5-2.50.0-0.8-0.91.02.4-1.00.91.3-0.1
Time in closed arm before self-admin2.22.55.4-0.21.6-2.11.90.10.1-1.82.32.0-1.9-0.11.9-1.91.2-1.5
Time in closed arm after self-admin0.30.30.70.30.0-0.2-0.0-0.6-0.6-0.10.40.5-0.50.70.5-0.50.9-0.7
Time in open arm before self-admin2.93.17.00.7-2.12.5-1.6-0.5-0.41.4-2.6-2.32.10.6-2.22.1-1.01.7
Time in open arm after self-admin0.80.92.00.4-1.11.3-0.30.10.10.3-1.0-1.31.3-0.0-1.41.3-0.61.2
Bone: periosteal estimation0.91.94.21.4-2.12.0-1.2-1.3-1.21.0-1.5-1.41.41.3-1.41.40.10.8
Bone: periosteal perimeter0.61.02.20.6-1.41.5-1.2-0.4-0.31.1-1.3-1.11.10.6-1.21.1-0.20.9
Bone: post-yield work1.41.95.12.2-1.50.80.6-2.3-2.2-1.00.40.3-0.42.00.4-0.41.7-1.1
Progressive ratio test 1 active lever presses2.42.54.82.2-0.8-0.31.7-1.9-1.9-1.91.51.3-1.11.91.1-1.22.2-1.6
Progressive ratio test 1 breakpoint1.71.84.12.0-1.00.11.2-1.7-1.7-1.51.10.9-0.71.80.7-0.81.8-1.2
Progressive ratio test 1 inactive lever presses2.93.25.32.1-0.3-0.51.8-2.0-2.0-2.11.81.8-1.61.81.6-1.72.3-2.1
Progressive ratio test 2 active lever presses1.92.03.81.7-0.3-0.71.8-1.4-1.5-1.91.21.3-1.21.41.2-1.21.9-1.5
Progressive ratio test 2 breakpoint1.51.73.61.6-0.2-0.71.8-1.2-1.3-1.91.11.2-1.11.21.1-1.11.8-1.3
Progressive ratio test 2 inactive lever presses5.15.99.52.6-0.4-0.82.2-2.5-2.6-2.52.42.4-2.52.72.5-2.63.1-3.1
Incentive Sensitization - Responses0.40.40.80.7-0.0-0.50.9-0.6-0.6-0.90.20.6-0.60.60.7-0.70.9-0.7
Incentive Sensitization - Breakpoint0.30.30.60.6-0.1-0.40.7-0.6-0.6-0.80.10.5-0.60.60.6-0.60.8-0.7
Sum of active levers in priming session hrs 5-60.10.10.5-0.1-0.40.4-0.6-0.1-0.10.6-0.7-0.30.20.2-0.20.20.00.1
Progressive ratio0.10.10.60.40.1-0.20.80.00.0-0.70.60.3-0.2-0.10.1-0.20.2-0.1
Food seeking constrained by brief footshock0.81.02.81.4-1.71.6-0.5-0.9-0.80.3-0.5-0.81.01.0-1.11.00.50.5
Seeking ratio, punishment vs. effort0.20.30.90.8-0.80.6-0.2-0.8-0.80.0-0.00.00.11.0-0.00.00.8-0.3
Retroperitoneal fat weight0.72.27.7-2.31.7-1.0-0.51.91.81.0-0.4-0.50.6-2.8-0.60.7-2.21.3
Reaction time number correct0.10.10.20.2-0.10.2-0.4-0.2-0.20.3-0.5-0.40.4-0.2-0.30.4-0.40.2
Reaction time mean minus median0.30.40.90.1-0.80.9-0.6-0.1-0.10.5-0.9-0.60.70.5-0.70.7-0.00.5
Reaction time mean minus median AUC0.71.02.10.2-1.31.4-1.2-0.2-0.21.0-1.3-1.11.10.6-1.21.1-0.30.9
Reaction time num false alarms0.30.41.0-0.80.9-1.00.20.60.5-0.00.80.8-0.8-0.20.9-0.80.3-0.5
Reaction time num false alarms AUC0.50.61.3-1.11.1-1.10.40.90.9-0.20.80.8-0.8-0.40.9-0.80.2-0.5
Reaction time trials correct on left0.10.10.20.2-0.10.2-0.4-0.2-0.20.3-0.5-0.40.4-0.2-0.30.4-0.40.2
Reaction time trials on left0.10.10.30.1-0.10.2-0.4-0.1-0.10.4-0.5-0.40.4-0.3-0.40.4-0.50.3
Reaction time mean0.10.20.70.5-0.80.60.1-0.4-0.4-0.2-0.4-0.30.30.8-0.40.30.40.2
Reaction time mean AUC0.10.10.40.3-0.60.50.2-0.1-0.1-0.2-0.4-0.30.30.5-0.40.30.20.3
Median of all reaction times0.10.10.40.5-0.60.20.4-0.3-0.3-0.4-0.0-0.0-0.00.7-0.10.00.5-0.0
Reaction time omissions0.20.30.7-0.50.00.30.10.70.70.3-0.5-0.70.5-0.5-0.70.6-0.80.8
Reaction time false alarm rate0.40.61.0-0.90.9-1.00.60.70.7-0.40.90.9-0.9-0.11.0-0.90.5-0.6
Reaction time premature initiation rate0.71.01.61.00.2-0.61.1-0.7-0.6-1.11.11.1-1.10.91.1-1.11.3-1.2
Reaction time premature initiations0.40.61.01.00.1-0.50.7-0.7-0.7-0.80.80.9-0.80.70.9-0.91.0-1.0
Std. dev. reaction times0.30.51.70.7-1.31.0-0.1-0.7-0.7-0.1-0.6-0.40.41.2-0.60.40.50.1
Reaction time trials completed0.10.10.30.1-0.10.2-0.4-0.1-0.10.4-0.5-0.40.4-0.3-0.40.4-0.50.3
Reaction time trials AUC0.20.30.7-0.3-0.10.2-0.60.20.20.6-0.7-0.70.7-0.6-0.60.6-0.80.6
Run reversals in cocaine runway, females0.50.41.50.9-1.20.6-0.4-1.0-1.00.1-0.1-0.00.01.0-0.1-0.00.7-0.4
Run reversals in cocaine runway, males3.83.76.2-2.10.50.8-1.42.32.31.8-1.7-1.82.0-2.4-1.92.0-2.22.5
Latency to leave start box in cocaine runway0.60.71.81.0-0.70.0-0.2-1.2-1.2-0.10.60.5-0.61.40.6-0.61.2-1.0
Latency to leave start box in cocaine runway, F0.70.71.40.9-0.2-0.30.2-1.1-1.1-0.40.70.7-0.91.00.9-0.91.2-1.2
Latency to leave start box in cocaine runway, M0.10.10.5-0.2-0.50.3-0.70.10.10.6-0.0-0.30.20.4-0.30.20.10.1
Std. dev. time between licks in bursts2.42.95.71.70.3-0.72.3-1.3-1.3-2.41.81.9-1.71.31.7-1.72.0-1.9
Total sessions with >9 infusions0.50.51.9-0.10.9-1.11.40.40.3-1.10.80.8-0.6-0.50.6-0.60.2-0.3
Short access day 1 total inactive lever presses3.64.07.12.0-0.1-1.01.5-2.0-2.0-1.82.02.2-2.22.02.2-2.32.5-2.7
Short access day 10 total inactive lever presses0.50.51.51.0-0.80.7-0.4-1.2-1.20.00.00.1-0.31.20.2-0.30.8-0.8
Short access day 1 total infusions0.40.41.40.50.1-0.61.2-0.3-0.4-1.20.50.6-0.60.40.5-0.60.7-0.6
Short access day 10 total infusions0.40.51.20.20.4-0.81.0-0.1-0.2-0.91.10.9-0.80.20.7-0.80.7-0.6
Short access total infusions0.40.51.6-0.10.7-1.01.30.30.2-1.10.90.7-0.6-0.30.5-0.60.3-0.3
Short access day 1 locomotion0.20.20.30.20.5-0.50.4-0.2-0.2-0.40.40.5-0.5-0.00.5-0.50.3-0.5
Short access day 10 total locomotion1.51.73.82.0-0.4-0.11.4-1.6-1.6-1.61.31.2-1.01.41.0-1.01.7-1.3
Short access total locomotion1.01.02.00.21.1-1.21.40.0-0.0-1.31.41.3-1.2-0.11.1-1.10.6-0.9
One hour access (0.3 mA shock)3.03.57.72.8-1.1-0.12.5-2.0-2.0-2.81.61.3-1.12.21.0-1.12.5-1.6
Compulsive drug intake0.00.00.10.1-0.20.20.40.00.0-0.30.1-0.10.2-0.0-0.20.20.20.2
One hour access (shock baseline)1.92.24.31.7-0.2-0.72.0-1.2-1.3-2.11.61.4-1.31.41.3-1.41.8-1.6
Social response proportion0.60.61.90.6-0.91.1-1.4-1.0-0.91.0-0.9-0.40.31.0-0.30.20.2-0.2
Social responses0.10.21.3-0.0-0.10.5-1.2-0.1-0.00.9-0.4-0.10.10.3-0.00.00.0-0.1
Social time1.31.85.52.1-1.91.4-0.6-2.1-2.00.1-0.4-0.30.22.3-0.30.11.3-0.6
Soleus weight0.10.30.8-0.90.4-0.2-0.50.80.80.7-0.2-0.30.2-0.7-0.20.2-0.80.4
Bone: stiffness0.60.92.61.4-1.31.2-0.8-1.6-1.60.5-0.5-0.60.61.0-0.40.60.2-0.1
Tibialis anterior weight0.92.96.6-1.8-0.30.9-2.41.31.32.6-1.7-1.81.6-1.3-1.81.6-2.11.9
Time to tail flick, vehicle, before self-admin0.60.61.5-0.21.0-1.11.10.30.2-1.01.20.9-0.9-0.20.8-0.9-0.0-0.6
Time to tail flick, vehicle, after self-admin0.10.10.3-0.30.5-0.20.30.50.6-0.20.40.2-0.0-0.30.00.0-0.10.2
Time to tail flick, test, before self-admin3.53.45.22.1-0.0-1.12.0-2.1-2.2-2.31.81.8-1.81.61.7-1.82.1-2.1
Time to tail flick, test, after self-admin0.20.20.50.6-0.1-0.20.7-0.6-0.6-0.70.30.3-0.30.20.2-0.30.2-0.4
Delta time to tail flick, vehicle, before/after SA0.10.10.40.4-0.50.7-0.0-0.1-0.10.0-0.3-0.30.50.3-0.40.50.40.4
Delta time to tail flick, test, before/after SA2.32.14.0-1.90.60.3-0.91.92.01.3-1.1-1.21.2-1.8-1.21.3-1.91.7
Tibia length1.64.410.72.6-3.32.8-1.7-2.6-2.61.2-2.0-1.91.91.9-2.01.80.30.7
Ambulatory time before self-admin0.00.00.1-0.30.2-0.20.20.30.3-0.1-0.2-0.10.0-0.30.00.0-0.00.0
Ambulatory time after self-admin2.42.67.62.4-2.82.2-0.8-2.3-2.20.2-1.0-0.91.12.0-0.91.01.1-0.2
Bone: tissue strength1.51.43.71.8-1.71.2-0.1-1.9-1.9-0.30.00.10.11.9-0.1-0.01.4-0.8
Total heroin consumption0.40.40.90.9-0.40.00.3-0.8-0.8-0.50.30.6-0.60.80.7-0.60.9-0.8
Bone: trabecular number0.81.32.91.7-1.61.5-0.7-1.7-1.70.4-0.9-0.91.10.8-1.01.00.10.4
Bone: trabecular spacing0.50.72.4-0.9-0.10.5-0.21.51.60.5-0.6-0.60.6-0.5-0.80.7-0.51.0
Bone: trabecular thickness0.10.10.50.4-0.30.1-0.7-0.6-0.60.5-0.2-0.20.20.1-0.20.2-0.10.0
Bone: trabecular tissue density2.63.79.9-3.11.4-0.6-0.83.13.11.5-1.0-1.11.0-2.6-1.11.1-2.42.0
Water consumed over 24 hours0.30.40.90.6-0.80.7-0.9-0.7-0.70.6-0.8-0.50.50.5-0.50.5-0.00.2
Number of responses in last shaping day2.52.55.41.50.2-1.02.2-1.3-1.3-2.31.51.6-1.61.21.6-1.62.0-1.8